Digital Commons Network^™

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Sertoli Cell Only Syndrome (Secos): Lessons From Case Studies, Jamsheer J Talati, Hizbullah Sheikh

Section of Urology

Between June 85 and December 87, 69 testicular biopsies were submitted for histopathological examination during investigation of infertility; ten (14%) patients had a Sertoli cell only syndrome. The history, clinical features, and hormonal profiles were analyzed in an attempt to categorize these patients on aetiological basis. Two followed treatment of malignancy--one by radiation for testicular cancer and one by cyclophosphamide for a lymphoma. One had unilateral cryptorchidism. Mumps was etiological factor in one patient. FSH levels determined in 6 patients were elevated in all suggesting a possible dependence of (sick) Sertoli cells on spermatogenic cells for production of inhibin. Alternative …

Collagenous Colitis, Z Abbas, S Abid, S Hamid, W Jafri, H Khan

Section of Gastroenterology

No abstract provided.

Expression Of A Human Cartilage Procollagen Gene (Col2a1) In Mouse 3t3 Cells., Leena Ala-Kokko, James Hyland, Carol Smith, Kari I. Kivirikko, Sergio A. Jimenez, Darwin J. Prockop

Department of Medicine Faculty Papers

Expression in a recombinant system has been difficult to obtain for any of the major fibrillar collagens that require processing by eight or more post-translational enzymes. Here, two DNA constructs were designed so that the promoter region of the gene for the pro-alpha 1(I) chain of human type I procollagen drove expression of the human type II procollagen gene in mouse NIH 3T3 cells, a culture line that normally synthesizes type I procollagen but not any cartilage-specific protein such as type II procollagen. Both constructs were expressed as both mRNA and protein. In clones expressing the construct at high levels, …

A 5 Year Retrospective Case Study Of Penetrating Ocular Trauma At The Aga Khan University Hospital, Karachi, S Qarab Hasnain, Muzaffar Kirmani

Section of Ophthalmology

Ocular Trauma is an important cause of monocular visual impairment and blindness in younger age groups. We examined the cases of hospitalized ocular trauma from 1st January, 1985 through 30th July, 1990 using hospital medical records. The study comprised 27 patients (28 eyes), 51.8% of whom were under 16. The male-female ratio was 2.8:1. Right eye was more commonly involved (66.6%) and one patient had bilateral ruptured globes. Children at play were most vulnerable (33.3%) followed by road accidents which was the major cause (29.6%) in adults. Sixteen (64.0%) eyes suffered some complications and their mean duration of presentation after …

[Review Of] Male Sexual Health, Robert A. Aken

Library Faculty and Staff Publications

No abstract provided.

Hepatic Dysfunction In Falciparum Malaria, J Khan, J Akhter, H Sheikh, W Jafri

Department of Pathology and Laboratory Medicine

No abstract provided.

Current Concepts In The Diagnosis And Management Of Childhood Asthma, Z A. Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Female Condoms, An Urgent Need, Mary Guinan

School of Public Health Faculty Research

As of February 1991, more than 16,000 cases of AIDS in women had been reported in the United States, but the ". tidal wave of cases in women is yet to come. World Health Organization (WHO) estimates of the number of women infected with the human immunodeficiency virus (HIV) range from 1.5 million in Africa to I 00,000 in the United States. Within the next ten years, the majority of these women will develop AIDS and die. Some will live a bit longer, but all are eventually doomed to die prematurely. Most will not live to see their 40th year.

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• Two Highest Ranking Medical Officers Receive Honorary Degrees - Brig. Gen. Ronald R. Blanck & Rear Admiral Hugh P. Scott
• Second Career Dos are among PCOM's Outstanding Graduates
• Bright Future on the Horizon as Master Facility Plan Begins
• Tackling Tough Issues
• Osteopathic Medicine + Research = Challenging Career Path
• On Campus
• New Appointments
• Just Published
• Class Acts
• In Memoriam
• Coming Events

A Clinicopathological Analysis Of Ovarian Tumours, M Saeed, K Khawaja, I Rizwana, Iffat Rizwana, J Rizvi, Imtiaz Malik, A Khan

Department of Obstetrics & Gynaecology

We performed a retrospective analysis of patients with ovarian tumors who were admitted to the Aga Khan University Hospital from January 1985 to December 1989. Sixty one cases were reviewed. Mean age of the whole group was 44 years. Majority of the patients presented with abdominal pain and distention. Most frequent physical finding was a palpable mass on pelvic or abdominal examination. Overall these patients had a higher incidence of breast cancer than expected in the general population. Two-thirds of the tumors were malignant. Comparison of the patients with malignancy against those with benign tumors failed to show any correlation …

Transcutaneous Bilirubinometry In Pakistani Newborns: A Preliminary Report, Z A. Bhutta, K Yusuf

Department of Paediatrics and Child Health

Neonatal hyperbilirubinemia is a frequently encountered problem in the neonatal period and carries a potential risk of encephalopathy. Early detection and quantification is important, and transcutaneous bilirubinometry (TcB) has been recommended as a non-invasive method for rapid screening. We prospectively compared the efficacy of TcB in 65 normal Pakistani jaundiced newborns undergoing simultaneous serum bilirubin measurements. Although the correlation between the two methods was significant (r = 0.66, P less than 0.01), the scatter was wide and the specificity only 53%. Although the technique offers the potential for non-invasive early screening of neonatal hyperbilirubinemia, it requires further validation in a …

Inclusion Of Data On Relatives For Estimation Of Allele Frequencies, R Chakraborty

Faculty, Staff and Student Publications

No abstract provided.

Department Of Radiology-Annual Report-July 1, 1990 To June 30, 1991, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1990 to June 30, 1991. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 84 pages.

Current Issues In The Leukemias, Howard R. Terebelo

Henry Ford Hospital Medical Journal

No abstract provided.

Predicting Survival In The Advanced Cancer Patient, Robert J. Miller

Henry Ford Hospital Medical Journal

No abstract provided.

Heterogeneity Of Methotrexate Binding In Human Colon Tumor Cells, M P. Iqbal, N Mehboobali, M A. Waqar, M Ahmed

Department of Biological & Biomedical Sciences

[3H]-methotrexate binding at pH 5.0 and pH 7.2 by the cytosol of tumor tissues and the surrounding normal areas of the gastrointestinal tract of patients suffering from colon or gastric cancer has been used to identify in these cells the presence of a binder of methotrexate having low-affinity for this drug in addition to the enzyme dihydrofolate reductase. Scatchard analysis of the [3H]-methotrexate binding data by a colon tumor sample also reveals that there are two binders of this drug present in the cytosol of these cells. The association constant (Kass) for one binder of methotrexate is = 5.6 x …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Hospice Care: An Overview, Josefina B. Magno

Henry Ford Hospital Medical Journal

No abstract provided.

Effect Of Delays In Processing On The Survival Of Mycobacterium Avium-M. Intracellulare In The Isolator Blood Culture System., C. Fordham Von Reyn, Stephen Hennigan, Sandra Niemczyk, Nicholas J. Jacobs

Dartmouth Scholarship

Concentrations of Mycobacterium avium-M. intracellulare ranging from 10(-1) to 10(3) CFU/ml were added to blood, placed in Isolator tubes, and held at room temperature for intervals ranging from 4 h to 56 days before being processed (centrifugation and culture on Middlebrook 7H10 agar). At all concentrations tested, M. avium-M. intracellulare was recovered after hold times ranging from 4 h to 7 days; the number of final CFU actually increased progressively for hold times of 8 h or more. Hold times of up to 7 days did not increase the time from processing to the first appearance of visible colonies. At …

Successful Eradication Of Flavobacterium Meningosepticum Neonatal Meningitis With Ceftizoxime, Z A. Bhutta, S H. Naqvi

Department of Paediatrics and Child Health

No abstract provided.

Fulminant Hepatic Failure With Typhoid Fever In Childhood, Z A. Bhutta

Department of Paediatrics and Child Health

Although hepatic dysfunction has been described among adults with typhoid, there are few reports of significant hepatic functional impairment in children with typhoid. Of 355 children with culture proven typhoid seen at the Aga Khan University Hospital, hepatomegaly was noted in 118 (33%) and isolated right hypochondrial tenderness in 30 (8.5%). The liver function tests were normal in 78% and 47% of these children respectively and significant hepatic dysfunction was seen only in 26 (7.3%). However, children with typhoid and significant hepatic dysfunction had higher mortality (P less than 0.001) and two patients presented with a picture of fulminant hepatic …

The Use Of Corrected Occlusal X-Ray For Determination Of Ald : A Comparative Study, Merlin D. Ekvall

Loma Linda University Electronic Theses, Dissertations & Projects

In this study arch length discrepancy or ALD was studied in 50 untreated patients. The measurements obtained from Hilgers' corrected occlusal x-ray using his Occlusal Paralleling Instrument or O.P.I, were compared with those derived by four conventional methods, - "Eye balling," digital caliper determination, conventional mandibular x-ray, and the Rocky Mountain Data Systems computer analysis (31 cases). When using the OPI, results give a higher negative ALD as it takes into consideration the space required to level a curve of Spee.

Measurements were made by the author and 3 faculty members using the above methods. Statistical analysis of the means …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President’s Perspective
• A Role Model for the Profession
• Founders Day 1991 Highlights
• More News From the Gulf
• A Double Header:
• A Tale of Two
• Team Physicians
• “Tell Me Where It Hurts” - Students Refine Skills
• On Campus
• Alumni News
• Coming Events

Ua12/2/1 Magazine, Wku Student Affairs

WKU Administration Documents

Special magazine edition of the College Heights Herald:

• Poore, Chris. Silent Escape – Amy Deputy, Bulimia

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Epidural Spinal Cord Compression From Metastatic Cancer: Clinical Features And Management, H Shaheen, S Abubakar, I Malik, I Altafullah, F Alam, A Khan

Section of Nephrology

We retrospectively analyzed thirty-three patients (21 males, 12 females) with malignancy induced spinal cord compression (SCC). The mean age of the patients was 42.8 years and almost half (51%) of them presented with SCC. Mean duration of symptoms was 4.5 months and the mean interval between the original diagnosis of cancer and the development of SCC was 14.6 months. Back pain was the most frequent (97%) symptom with an equal number of patients having subjective or objective evidence of lower limb weakness. Majority (73%) of the patients were non-ambulatory at the time of diagnosis. Spinal level involvement was mostly thoracic …

The Phenomenology Of Cushing's Syndrome: One Patient's Account, Andrew Armstrong, J. David Fachnie

Henry Ford Hospital Medical Journal

Cushing's syndrome caused by ectopic secretion of adrenocorticotropic hormone (ACTH) is often a serious disease and a diagnostic dilemma. In the reported patient, the source of ACTH proved to he a benign pulmonary carcinoid tumor. The patient describes his trying experiences through the six months from initial diagnosis to definitive therapy.

The Effects Of Suxamethonium And Pancuronium On The Haemodynamic Response To Endotracheal Intubation, F A. Khan, R S. Kamal

Department of Anaesthesia

The pharmacological effects of suxamethonium and pancuronium on the cardiovascular system may vary and therefore alter the haemodynamic response to intubation. The arterial blood pressure, the heart rate and the rate pressure product were measured as parameters of haemodynamic change in forty adult ASA. I and II patients undergoing laryngoscopy and endotracheal intubation in a randomised controlled study. The patients were induced with either thiopentone/suxamethonium (Group A) or thiopentone/pancuronium (Group B). There was no significant difference between the groups on comparison of systolic and diastolic blood pressure changes. Pancuronium, however, caused a significantly higher rise in the heart rate after …