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Department Of Radiology-Annual Report-July 1, 1986 To June 30, 1987, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1986 to June 30, 1987. Thomas Jefferson University Hospital, Philadelphia,Pennsylvania, United States. 106 pages.

Plasma And Tumor Levels Of Somatostatin (Srif) And Somatostatin Immunochemistry In Medullary Thyroid Carcinoma: Apparently Discrepant Preliminary Results, B. Franc, J. A. Chayvialle, E. Modigliani, C. Calmettes, B. Caillou, N. Dutrieux-Berger, C. Houdent, M. Kujas

Henry Ford Hospital Medical Journal

Eighteen cases of medullary thyroid carcinoma (MTC) (11 hereditary) had parallel measurements of basal plasma levels of somatostatin (SRIF), levels of SRIF extracted from fresh tumor tissue (radioimmunoassay), and immunohistochemistry (peroxidase-antiperoxidase method) using an anti-SRIF antibody on paraffin sections. Immunohistochemistry disclosed some cell positivity in nine cases (50%). Plasma levels of SRIF were above normal (> 50 pg/mL expressed in terms of the 14 amino acid SRIF peptide) in only two of 12 patients. Extraction of fresh tumor tissue detected SRIF in 60% of our cases: two patients > l.200pg/mg (equivalents 14). with the other positive values ranging between 13 and …

Immunohistochemistry In Medullary Thyroid Carcinoma: Prognosis And Distinction Between Hereditary And Sporadic Tumors, B. Franc, B. Caillou, A. M. Carrier, N. Dutrieux-Berger, J. Floquet, M. Houcke, E. Justrabo, F. Lange, A. Pages, C. Rigaud, A. Schwartz, M. Viennet, M. F. Lebodic

Henry Ford Hospital Medical Journal

In this retrospective study of 68 cases of medullary thyroid carcinoma (MTC), morphological features were studied, which could be helpful in prognosis and in the distinction between hereditary and sporadic forms of the disease. Necrosis within the tumors seemed to carry a poor prognosis. Bilateral MTC. unquestionable C-cell hyperplasia, glandular or follicular pattern, and thyroglobulin-positive cells seemed to be more prevalent in hereditary forms of the disease. A smaller proportion of calcitonin-immunoreactive cells were encountered in hereditary tumors than in sporadic tumors.

Different Mechanisms Of Calcitonin, Calcitonin Gene-Related Peptide, And Somatostatin Regulation By Glucocorticoids In A Cell Culture Of Human Medullary Thyroid Carcinoma, Gilbert J. Cote, Robert F. Gagel

Henry Ford Hospital Medical Journal

We have employed the TT cell line, a model for the human medullary thyroid carcinoma cell, lo study the regulation of peptide hormone production by glucocorticoids. Complementary DNA probes were used to measure the calcitonin (CT), CT gene-related peptide (CGRP), and somatostatin (SRIF) mRNA levels. Dose-response experiments in serum-free medium showed that dexamethasone (six-day treatment) lowered somatostatin (to 1% of basal) and CGRP mRNA (to 50% of basal) and stimulated CT mRNA (threefold to thirteenfold) with a half-maximal effective concentration of 10⁻⁸ M. Time course studies for cells continuously exposed to 10⁻⁶ M dexamethasone showed a rapid (within …

The Second International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Bruce A. J. Ponder, Charles E. Jackson

Henry Ford Hospital Medical Journal

No abstract provided.

Calcitonin Gene-Related Peptide And Calcitonin In Men-2 And Sporadic Pheochromocytomas: An Immunohistochemical Study, Lis Johannsen, Henrik Daa Schroder, Soren Schifter

Henry Ford Hospital Medical Journal

Ten pheochromocytomas (five from patients with multiple endocrine neoplasia type 2 and five sporadic) were stained immunohistochemically with antibodies to calcitonin (CT) and calcitonin gene-related peptide (CGRP) by means of the peroxidase-antiperoxidase method. CGRP positive cells were found in variable numbers in all of the investigated tumors. No demonstrable difference was noted between the hereditary tumors and the sporadic tumors. Staining with CT antibody also showed cells with a positive reaction in eight of ten tumors. The distribution of the two peptides was similar, and in some cells their coexistence was visualized. Pheochromocytomas thus represent an alternative site to medullary …

Clinical Value Of Calcitonin And Carcinoembryonic Antigen Doubling Times In Medullary Thyroid Carcinoma, Charles E. Jackson, Robert A. Norum, Gary B. Talpos, Carolyn S. Feldkamp, Armen H. Tashjian Jr.

Henry Ford Hospital Medical Journal

Doubling times of basal and stimulated calcitonin (CT) levels and of random carcinoembryonic antigen (CEA) levels were compared over time in 11 patients with residual medullary thyroid carcinoma (MTC)—five with the sporadic MTC and six with the hereditary MTC. Four patients with an indolent form of the disease showed little change in CT levels over three to eight years and little change in CEA doubling times (42 to 70+ months). Seven patients showing rapid progression of disease had CT doubling times of three to 11 months and CEA doubling times of two to 12 months (however, one patient showed no …

In Vitro Secretion Of Peptides Of The Calcitonin Family: Calcitonin, Katacalcin, And Calcitonin Gene-Related Peptide, Friedhelm Raue, Hubert Serve, Eckard Rix, Reinhard Ziegler

Henry Ford Hospital Medical Journal

A tissue culture explant and a primary cell culture of malignant C-cells have been estabUshed to study the secretion pattern of calcitonin (CT), katacalcin (KC), and CT gene-related peptide (CGRP) in vitro under different conditions. Within the first five days of culture the spontaneous secretion of the peptides in both systems dropped to and remained at a constant level. With increasing calcium (Ca) concentration in the medium, a dose dependent release of CT, KC and, in cell culture, of CGRP was observed. BAY-K-8644. an analog of the Ca channel blocker nifedipine, enhanced the CT secretion to the same extent as …

Localization Of A Radiolabeled Monoclonal Antibody To Calcitonin In Rat Medullary Thyroid Carcinoma Allografts, Naguib A. Samaan, Kuo-Pao Yang

Henry Ford Hospital Medical Journal

A radiolabeled anticalcitonin monoclonal antibody (MoAb) was testedfor tumor-localizing capability in WAG/Rij rats allografted with cultured medullary thyroid carcinoma cells (line 44-2). 131I-labeled anticalcitonin IgG was taken up by the tumors in a time-dependent and dose-dependent manner. Tumor tissue uptake of the injected MoAb was 0.7 to 1.3%/g of tumor tissue when tested with a dose range of 40 lo 250 μg/kg of body weight. Distribution ratios of the radiolabeled MoAb were 1.2:1 for tumor-to-blood and 2-20:1 for tumor-to-organs. In rats injected with control IgG, disiribution ratios of radioactivity were 0.4:1 for tumor-to-blood, and 0.6-2:1 for tumor-to-organs. These results suggested …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Vital Signs, Spring 1987, Boonshoft School Of Medicine

Vital Signs

A thirty six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

The Clinicians' Guide To Creutzfeldt-Jakob Disease, Thomas H. Swanson

Henry Ford Hospital Medical Journal

Creutzfeldt-Jakob disease, a transmissible, rapidly progressive dementia of unknown etiology, mimics Alzheimer's disease, presents in middle life, and affects many central nervous system structures. The disease progresses in three distinct stages, culminating in death. Its occurrence is sporadic and its distribution worldwide. Pathological changes are varied, but spongy degeneration of the neuropil is classic. Research on scrapie, the animal model of Creutzfeldt-Jakob disease, has demonstrated that this unconventional, slow disease is transmitted via a small (less than 50,000 mW) particle, which is composed principally of protein. How this infectious particle, variably named prion, virino, or slow virus, invokes disease or …

The Effects Of Alpha Adrenergic Blockade On Arachidonic Acid Metabolism And Shock Sequelae During Septic Shock In The Rat, Jeffrey Armstrong

MUSC Theses and Dissertations

Increased activity of the alpha adrenergic nervous system may be a significant factor promoting tissue ischemia in endotoxic shock. The suggestion that increased sympathetic activity affects prostaglandin synthesis prompted investigation of the potential interaction between the adrenergic nervous system and arachidonic acid metabolites during endotoxemia and septicemia. In addition, the possibility that the underlying patterns of arachidonic acid metabolites seen in two different shock models may provide a rationale for therapeutic intervention designed to block either or both the synthesis of arachidonic acid metabolites or the activity of the adrenergic nervous system was examined. Studies were undertaken to determine the …

Biochemical And Histological Evaluation Of Normal Human Epidermis Vs Cultured Human Epidermis, Ngo Thi Bich Lien

Biological Sciences Theses & Dissertations

Cultured human keratinocytes were grown in vitro for transplantation purposes in case of severe burns. Single keratinocytes were harvested from human epidermis and grown in culture flasks such that multilayered sheets of keratinocyte cells were harvestable in approximately three weeks. In order to evaluate cultured epidermis for equivalency with normal human epidermis, biochemical and histological studies were performed. Thin sections of cultured epidermis were shown to be composed of cells that had undergone developmental differentiation, but not terminal differentiation. Biochemical analyses of keratin and prekeratin proteins isolated from cultured epidermis indicated that cultured keratinocytes have electrophoretic patterns similar to keratins/prekeratins …

Oncolog, Volume 32, Number 02, April-June 1987, Lillian M. Fuller Md, Gabriel Lopez-Berestein

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Limited Chemotherapy and Radiotherapy Effective in Stage I and II Hodgkin's Disease in Adults
• Gene Rearrangement May Affect Prognosis of Some Chronic Myelogenous Leukemia Patients
• Liposomal Antibiotic Better, Less Toxic Than Free Drug for Treating Fungal Infections

Oncolog, Volume 32, Number 04, October-December 1987, Cheryl Mokrzecky

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Patients with Highly Invasive Cutaneous Melanoma Need Selective, Focused Evaluations Before Surgery\
• Diagnostic Radiologists Use Expandable Metallic Stents for Symptom Relief in Selected Patients
• Nutritional and Psychological Aspects of Feeding Children Who Have Cancer
• Adjuvant Chemotherapy Improves Survival of Patients with Stage II and III Breast Cancer

Oncolog, Volume 32, Number 03, October - December 1987, Douglas E. Johnson Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Improved Survival Results from Early Detection and Diagnosis of Testicular Cancer
• Current Laboratory Research Modernizes Traditional Chinese Herbal Medicine
• Gastrointestinal Radiotherapy Team Creates Atmosphere of Comfort and Confidence for Patients

Oncolog, Volume 32, Number 01, January-March 1987, Lovell A. Jones Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Anderson Physicians Staff AIDS Hospital to Advance Treatment and Halt Disease Spread
• Counseling Patients with AIDS and ARC Begins with Unconditional Acceptance
• The Realities of Cancer in Minority Communities

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1986), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1986 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• O. J. Snyder Award Laureate, David Heilig, DO
• Spunk Smooths Tough Path
• Elliot Ames, DO, Bringing a New Subspecialty to OMCP
• Ben Rubin, PhD - Protagonist in the Victory over Smallpox
• On Campus
• Something of Honor
• Class Acts
• In Memoriam
• Coming Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1986), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1986 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Making Them Comfortable
• John J. Fernandes, DO
• Pathology Department to be Computerized
• O.J. Snyder Award Recipient
• In the Land of Shoo-fly Pie
• Class Acts
• In Memorium
• How Sweet It Is
• On Campus
• Calendar

Vital Signs, Fall 1986, Boonshoft School Of Medicine

Vital Signs

A thirty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

New Positive Inotropic Agents, Syed M. Jafri, James A. Bristol

Henry Ford Hospital Medical Journal

Current therapy for heart failure remains inadequate. New positive inotropic agents that augment myocardial contractility have been introduced. The positive inotropic effects of these nonglycoside, nonsympathomimetic agents are due, at least in part, to inhibition of cardiac phosphodiesterase activity and hence to an increase in myocardial cyclic AMP levels. These agents also have vasodilator properties through their effects on the enzyme phosphodiesterase in the vascular smooth muscle. Recent developments in the preclinical pharmacology, mechanism of action, and clinical experience with these new inotrope vasodilators are presented in this review. The role these drugs will play in revising our therapeutic strategy …

Vital Signs, Summer 1986, Boonshoft School Of Medicine

Vital Signs

A twenty eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1986), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1986 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• 50 Yard Diagnosis
• The 95th Commencement
• Jeffrey B. Alpern, D.O.
• Leap of Logic
• On Campus
• America Eight Day Odyssey 18
• Class Acts
• In Memoriam
• Calendar

Nineteen-Year Radiographic Follow-Up Of Untreated Paget's Disease Of Bone, Christopher K. Shier, Burton I. Ellis, Gregory Tennyson, Michael Kleerekoper

Henry Ford Hospital Medical Journal

Radiographic and histologic findings in Paget's disease of bone have been previously well described, and characteristic features of each stage have been determined. Long-term radiographic follow-up of untreated patients is rarely reported. We had the opportunity to observe the radiographic evolution of untreated Paget's disease of the tibia. Sequential radiographic studies spanning a 19-year period have allowed us the opportunity to study the natural course of this disease.

Hemodynamic Response To Fluid Challenge: A Means Of Assessing Volume Status In The Critically Ill, H. Mathilda Horst, Farouck N. Obeid

Henry Ford Hospital Medical Journal

Cardiovascular and oxygen transport variables were studied during fluid challenges in 50 critically ill patients. The results show three distinct patterns of response: hypovolemic, normovolemic, and hypervolemic. Colloid fluid challenge is a rapid, effective diagnostic modality for determination of cardiovascular function in the surgical critical care patient.

Axial Morphology And Angulation Of The Condyle In Relation To Malocclusions In Different Age Groups, Gerald P. Tadej

Loma Linda University Electronic Theses, Dissertations & Projects

Recent studies have shown that forces applied to the mandible during functional appliance and other orthodontic therapies produce measurable changes in the TMJ. It was postulated that specific malocclusions might also apply forces that could produce specific changes in the horizontal morphology of the TMJ. This study involved 104 pretreatment orthodontic patients, 44 males and 60 females. A submento-vertex analysis was performed and correlated with clinical findings including age, sex, malocclusion type, facial type, TMJ symptoms, tooth eruption sequence, crossbites and midline discrepancies. All possible correlations between the radiographic findings and the clinical malocclusions were tested with ANOVA. The width …

Correlates Of Birth Weight And Gestation Age : Baseline Data For Health Education, Adanetch Kidanemariam

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose. The study examined the correlation of maternal occupation, urinary tract infection, smoking, and working during pregnancy with infant birth weight and gestational age in order to generate baseline data for development of a health education intervention program protocol for pregnant women In the work place.

Primary Hypotheses. (1) The four maternal risk factors: (a) occupation during lifetime, (b) reported urinary tract infection, (c) cigarette smoking, (d) working, are individually and interactively correlated with infant birth weight and gestational age. (2) The effects of the interactive associations are greater on birth weight than gestational age.

Procedure. A sample of …

Magnesium, Copper And Zinc Concentrations In Blood From Children With Diabetes Mellitus, Linda Lowers Jenkins

Chemistry & Biochemistry Theses & Dissertations

Trace element levels in blood from diabetic children were investigated and compared to control children. Plasma, erythrocyte, mononuclear and polymorphonuclear cells were analyzed for magnesium, copper, and zinc content. Leukocyte separation was performed by density gradient centrifugation on Ficoll-Hypaque, followed by washing steps to remove platelet contamination and hypotonic lysis to remove red cell contamination. Polarized Zeeman-effect atomic absorption spectroscopy was used for trace metal analysis.

Decreased plasma magnesium levels were observed in the diabetic children. This finding is well documented and probably due to increased urinary magnesium loss from glycosuria. Lymphocyte magnesium levels in the diabetic children were also …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1986), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1986 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• PCOM's Dean
• Bridging It
• Caribbean CME
• Haiti Rotation
• A Family Affair
• On Campus
• Inventor Visits Campus
• Class Acts
• In Memorium
• Calendar