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Perfectionism Related To Self-Reported Insomnia Severity, But Not When Controlled For Stress And Emotion Regulation, S. Brand, R. Kirov, N. Kalak, M. Gerber, U. Puhse, S. Lemola, Christoph Correll, S. Cortese, T. Meyer, E. Holsboer-Trachsler Jan 2015

Perfectionism Related To Self-Reported Insomnia Severity, But Not When Controlled For Stress And Emotion Regulation, S. Brand, R. Kirov, N. Kalak, M. Gerber, U. Puhse, S. Lemola, Christoph Correll, S. Cortese, T. Meyer, E. Holsboer-Trachsler

Journal Articles

Background: Perfectionism is understood as a set of personality traits such as unrealistically high and rigid standards for performance, fear of failure, and excessive self-criticism. Previous studies showed a direct association between increased perfectionism and poor sleep, though without taking into account possible mediating factors. Here, we tested the hypothesis that perfectionism was directly associated with poor sleep, and that this association collapsed, if mediating factors such as stress and poor emotion regulation were taken into account. Methods: Three hundred and forty six young adult students (M=23.87 years) completed questionnaires relating to perfectionism traits, sleep, and psychological functioning such as …


Abnormal Movements In First-Episode, Nonaffective Psychosis: Dyskinesias, Stereotypies, And Catatonic-Like Signs, M. T. Compton, F. Fantes, C. R. Wan, S. Johnson, E. F. Walker Jan 2015

Abnormal Movements In First-Episode, Nonaffective Psychosis: Dyskinesias, Stereotypies, And Catatonic-Like Signs, M. T. Compton, F. Fantes, C. R. Wan, S. Johnson, E. F. Walker

Journal Articles

Motor abnormalities represent a neurobehavioral domain of signs intrinsic to schizophrenia-spectrum disorders, though they are commonly attributed to medication side effects and remain understudied. Individuals with first-episode psychosis represent an ideal group to study innate movement disorders due to minimal prior antipsychotic exposure. We measured dyskinesias, stereotypies, and catatonic-like signs and examined their associations with: (1) age at onset of psychotic symptoms and duration of untreated psychosis; (2) positive, negative, and disorganized symptoms; (3) neurocognition; and (4) neurological soft signs. Among 47 predominantly African American first-episode psychosis patients in a public-sector hospital, the presence and severity of dyskinesias, stereotypies, and …


Young-Onset Dementia Epidemiology Applied To Neuropsychiatry Practice, B. Devineni, C. U. Onyike Jan 2015

Young-Onset Dementia Epidemiology Applied To Neuropsychiatry Practice, B. Devineni, C. U. Onyike

Journal Articles

A substantial number of adults suffer young-onset dementia (YOD). The diversity of types and syndromes makes recognition and diagnosis difficult. An algorithmic approach to interpreting clinical data, informed by clinical epidemiology, integrates data pertaining to defining syndromes. Syndrome chronology and tempo, family history, and other neuropsychiatric features and neurologic signs, are used to reach a preliminary diagnosis and direct diagnostic tests and their interpretation. Screening for YOD in the psychiatric context is a rational process in which vigilance is combined with careful searches for red flags that signal a neurodegenerative etiology.


Six-Month Outcomes From A Randomized Trial Augmenting Serotonin Reuptake Inhibitors With Exposure And Response Prevention Or Risperidone In Adults With Obsessive-Compulsive Disorder, E. B. Foa, H. B. Simpson, D. Rosenfield, M. R. Liebowitz, S. P. Cahill, J. D. Huppert, J., Jr. Bender, C. P. Mclean, M. J. Maher, R. Campeas, C. G. Hahn, P. Imms, A. Pinto, M. B. Powers, C. I. Rodriguez, P. E. Van Meter, D. Vermes, M. T. Williams Jan 2015

Six-Month Outcomes From A Randomized Trial Augmenting Serotonin Reuptake Inhibitors With Exposure And Response Prevention Or Risperidone In Adults With Obsessive-Compulsive Disorder, E. B. Foa, H. B. Simpson, D. Rosenfield, M. R. Liebowitz, S. P. Cahill, J. D. Huppert, J., Jr. Bender, C. P. Mclean, M. J. Maher, R. Campeas, C. G. Hahn, P. Imms, A. Pinto, M. B. Powers, C. I. Rodriguez, P. E. Van Meter, D. Vermes, M. T. Williams

Journal Articles

OBJECTIVE: To compare outcomes after 6-month maintenance treatment of adults diagnosed with obsessive-compulsive disorder (OCD) based on DSM-IV criteria who responded to acute treatment with serotonin reuptake inhibitors (SRIs) augmented by exposure and response prevention (EX/RP) or risperidone. METHOD: A randomized trial was conducted at 2 academic sites from January 2007 through December 2012. In the acute phase, 100 patients on therapeutic SRI dose with at least moderate OCD severity were randomized to 8 weeks of EX/RP, risperidone, or pill placebo. Responders entered the 6-month maintenance phase, continuing the augmentation strategy they received acutely (n = 30 EX/RP, n = …


Memory Systems In Schizophrenia: Modularity Is Preserved But Deficits Are Generalized, K. M. Haut, K. H. Karlsgodt, R. M. Bilder, E. Congdon, N. B. Freimer, E. D. London, F. W. Sabb, J. Ventura, T. D. Cannon Jan 2015

Memory Systems In Schizophrenia: Modularity Is Preserved But Deficits Are Generalized, K. M. Haut, K. H. Karlsgodt, R. M. Bilder, E. Congdon, N. B. Freimer, E. D. London, F. W. Sabb, J. Ventura, T. D. Cannon

Journal Articles

OBJECTIVE: Schizophrenia patients exhibit impaired working and episodic memory, but this may represent generalized impairment across memory modalities or performance deficits restricted to particular memory systems in subgroups of patients. Furthermore, it is unclear whether deficits are unique from those associated with other disorders. METHOD: Healthy controls (n=1101) and patients with schizophrenia (n=58), bipolar disorder (n=49) and attention-deficit-hyperactivity-disorder (n=46) performed 18 tasks addressing primarily verbal and spatial episodic and working memory. Effect sizes for group contrasts were compared across tasks and the consistency of subjects' distributional positions across memory domains was measured. RESULTS: Schizophrenia patients performed poorly relative to the …


Genome-Wide Autozygosity Is Associated With Lower General Cognitive Ability, D. P. Howrigan, M. A. Simonson, G. Davies, S. E. Harris, A. Tenesa, J. M. Starr, D. C. Liewald, D. I. Boomsma, P. Derosse, M. C. Keller, +37 Additional Authors Jan 2015

Genome-Wide Autozygosity Is Associated With Lower General Cognitive Ability, D. P. Howrigan, M. A. Simonson, G. Davies, S. E. Harris, A. Tenesa, J. M. Starr, D. C. Liewald, D. I. Boomsma, P. Derosse, M. C. Keller, +37 Additional Authors

Journal Articles

Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, autozygosity can occur to varying degrees due to cryptic relatedness between parents. Using dense genome-wide single-nucleotide polymorphism (SNP) data, we examined the degree to which autozygosity associated with measured cognitive ability in an unselected sample of 4854 participants of European ancestry. We used runs of homozygosity-multiple homozygous SNPs in a row-to estimate autozygous tracts across the genome. We …


New Data And An Old Puzzle: The Negative Association Between Schizophrenia And Rheumatoid Arthritis, S. H. Lee, T. Lencz, A. K. Malhotra, H. Medeiros, V. Milanova, J. Shi, P. Sklar, P. K. Gregersen, M. Van Laar, P. Van Riel, +134 Additional Authors Jan 2015

New Data And An Old Puzzle: The Negative Association Between Schizophrenia And Rheumatoid Arthritis, S. H. Lee, T. Lencz, A. K. Malhotra, H. Medeiros, V. Milanova, J. Shi, P. Sklar, P. K. Gregersen, M. Van Laar, P. Van Riel, +134 Additional Authors

Journal Articles

BACKGROUND: A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative association is underpinned by genetic factors would test for reduced rates of one disorder in relatives of the other, but sufficiently powered data sets are difficult to achieve. The genomics era presents an alternative paradigm for investigating the genetic relationship between two uncommon disorders. METHODS: We use genome-wide common single nucleotide polymorphism (SNP) data from independently collected SZ and RA case-control cohorts to estimate the SNP correlation between the disorders. We …


Neural Substrates Of Inhibitory Control Deficits In 22q11.2 Deletion Syndrome, C. A. Montojo, M. Jalbrzikowski, E. Congdon, S. Domicoli, C. Chow, C. Dawson, K. H. Karlsgodt, R. M. Bilder, C. E. Bearden Jan 2015

Neural Substrates Of Inhibitory Control Deficits In 22q11.2 Deletion Syndrome, C. A. Montojo, M. Jalbrzikowski, E. Congdon, S. Domicoli, C. Chow, C. Dawson, K. H. Karlsgodt, R. M. Bilder, C. E. Bearden

Journal Articles

22q11.2 deletion syndrome (22q11DS) is associated with elevated levels of impulsivity, inattention, and distractibility, which may be related to underlying neurobiological dysfunction due to haploin-sufficiency for genes involved in dopaminergic neurotransmission (i. e. catechol-O-methyltransferase). The Stop-signal task has been employed to probe the neural circuitry involved in response inhibition (RI); findings in healthy individuals indicate that a fronto-basal ganglia network underlies successful inhibition of a prepotent motor response. However, little is known about the neurobiological substrates of RI difficulties in 22q11DS. Here, we investigated this using functional magnetic resonance imaging while 45 adult participants (15 22q11DS patients, 30 matched controls) …


The Navigate Program For First-Episode Psychosis: Rationale, Overview, And Description Of Psychosocial Components, K. T. Mueser, D. L. Penn, P. Meyer-Kalos, S. R. Mcgurk, C. Cather, S. Saade, D. G. Robinson, N. R. Schooler, R. A. Rosenheck, J. M. Kane, +6 Additional Authors Jan 2015

The Navigate Program For First-Episode Psychosis: Rationale, Overview, And Description Of Psychosocial Components, K. T. Mueser, D. L. Penn, P. Meyer-Kalos, S. R. Mcgurk, C. Cather, S. Saade, D. G. Robinson, N. R. Schooler, R. A. Rosenheck, J. M. Kane, +6 Additional Authors

Journal Articles

Comprehensive coordinated specialty care programs for first-episode psychosis have been widely implemented in other countries but not in the United States. The National Institute of Mental Health's Recovery After an Initial Schizophrenia Episode (RAISE) initiative focused on the development and evaluation of first-episode treatment programs designed for the U.S. health care system. This article describes the background, rationale, and nature of the intervention developed by the RAISE Early Treatment Program project-known as the NAVIGATE program-with a particular focus on its psychosocial components. NAVIGATE is a team-based, multicomponent treatment program designed to be implemented in routine mental health treatment settings and …


Severity Of Thought Disorder Predicts Psychosis In Persons At Clinical High-Risk, D. O. Perkins, C. D. Jeffries, B. A. Cornblatt, S. W. Woods, J. Addington, D. H. Mathalon, L. J. Seidman, M. T. Tsuang, E. F. Walker, T. H. Mcglashan, +4 Additional Authors Jan 2015

Severity Of Thought Disorder Predicts Psychosis In Persons At Clinical High-Risk, D. O. Perkins, C. D. Jeffries, B. A. Cornblatt, S. W. Woods, J. Addington, D. H. Mathalon, L. J. Seidman, M. T. Tsuang, E. F. Walker, T. H. Mcglashan, +4 Additional Authors

Journal Articles

BACKGROUND: Improving predictive accuracy is of paramount importance for early detection and prevention of psychosis. We sought a symptom severity classifier that would improve psychosis risk prediction. METHODS: Subjects were from two cohorts of the North American Prodrome Longitudinal Study. All subjects met Criteria of Psychosis-Risk States. In Cohort-1 (n=296) we developed a classifier that included those items of the Scale of Psychosis-Risk Symptoms that best distinguished subjects who converted to psychosis from nonconverters, with performance initially validated by randomization tests in Cohort-1. Cohort-2 (n=592) served as an independent test set. RESULTS: We derived 2-Item and 4-Item subscales. Both included …


Prevalence Of Childhood Obsessive-Compulsive Personality Traits In Adults With Obsessive Compulsive Disorder Versus Obsessive Compulsive Personality Disorder, A. Pinto, A. L. Greene, E. A. Storch, H. B. Simpson Jan 2015

Prevalence Of Childhood Obsessive-Compulsive Personality Traits In Adults With Obsessive Compulsive Disorder Versus Obsessive Compulsive Personality Disorder, A. Pinto, A. L. Greene, E. A. Storch, H. B. Simpson

Journal Articles

Identifying risk factors of psychopathology has been an important research challenge. Prior studies examining the impact of childhood temperament on adult disorder have largely focused on under-controlled and inhibited presentations, with little study of overcontrolled traits such as obsessive-compulsive personality traits (OCPTs). We compared rates of childhood OCPTs in adults with OCD (without OCPD) (n=28) to adults with OCPD (without OCD) (n=27), adults with both OCD and OCPD (n=28), and healthy controls (HC) (n=28), using the childhood retrospective perfectionism questionnaire, a validated measure of perfectionism, inflexibility, and drive for order. Adults with OCPD (both with and without comorbid OCD) reported …


Integration Of Palliative Care In The Context Of Rapid Response A Report From The Improving Palliative Care In The Icu Advisory Board, J. E. Nelson, K. S. Mathews, D. E. Weissman, K. J. Brasel, M. Campbell, J. R. Curtis, J. A. Frontera, M. Gabriel, R. M. Hays, D. R. Lustbader, +7 Additional Authors Jan 2015

Integration Of Palliative Care In The Context Of Rapid Response A Report From The Improving Palliative Care In The Icu Advisory Board, J. E. Nelson, K. S. Mathews, D. E. Weissman, K. J. Brasel, M. Campbell, J. R. Curtis, J. A. Frontera, M. Gabriel, R. M. Hays, D. R. Lustbader, +7 Additional Authors

Journal Articles

Rapid response teams (RRTs) can effectively foster discussions about appropriate goals of care and address other emergent palliative care needs of patients and families facing life-threatening illness on hospital wards. In this article, The Improving Palliative Care in the ICU (IPAL-ICU) Project brings together interdisciplinary expertise and existing data to address the following: special challenges for providing palliative care in the rapid response setting, knowledge and skills needed by RRTs for delivery of high-quality palliative care, and strategies for improving the integration of palliative care with rapid response critical care. We discuss key components of communication with patients, families, and …


The Impact Of Disease Duration On Quality Of Life In Children With Nephrotic Syndrome: A Midwest Pediatric Nephrology Consortium Study, D. T. Selewski, J. P. Troost, S. F. Massengill, R. A. Gbadegesin, L. A. Greenbaum, I. F. Shatat, Y. Cai, G. Kapur, C. B. Sethna, D. S. Gipson, +13 Additional Authors Jan 2015

The Impact Of Disease Duration On Quality Of Life In Children With Nephrotic Syndrome: A Midwest Pediatric Nephrology Consortium Study, D. T. Selewski, J. P. Troost, S. F. Massengill, R. A. Gbadegesin, L. A. Greenbaum, I. F. Shatat, Y. Cai, G. Kapur, C. B. Sethna, D. S. Gipson, +13 Additional Authors

Journal Articles

BACKGROUND: The Patient Reported Outcomes Measurement Information System (PROMIS) II is a prospective study that evaluates patient reported outcomes in pediatric chronic diseases as a measure of health-related quality of life (HRQOL). We have evaluated the influence of disease duration on HRQOL and, for the first time, compared the findings of the PROMIS measures to those of the PedsQL 4.0 Generic Scales (PedsQL) from the PROMIS II nephrotic syndrome (NS) longitudinal cohort. METHODS: This was a prospective study in which 127 children (age range 8-17 years) with active NS from 14 centers were enrolled. Children with active NS defined as …


Protocolized Sedation Vs Usual Care In Pediatric Patients Mechanically Ventilated For Acute Respiratory Failure: A Randomized Clinical Trial, M. A. Curley, D. Wypij, R. S. Watson, M. J. Grant, L. A. Asaro, I. M. Cheifetz, B. L. Dodson, L. S. Franck, R. G. Gedeit, J. Schneider, +2 Additional Authors Jan 2015

Protocolized Sedation Vs Usual Care In Pediatric Patients Mechanically Ventilated For Acute Respiratory Failure: A Randomized Clinical Trial, M. A. Curley, D. Wypij, R. S. Watson, M. J. Grant, L. A. Asaro, I. M. Cheifetz, B. L. Dodson, L. S. Franck, R. G. Gedeit, J. Schneider, +2 Additional Authors

Journal Articles

IMPORTANCE: Protocolized sedation improves clinical outcomes in critically ill adults, but its effect in children is unknown. OBJECTIVE: To determine whether critically ill children managed with a nurse-implemented, goal-directed sedation protocol experience fewer days of mechanical ventilation than patients receiving usual care. DESIGN, SETTING, AND PARTICIPANTS: Cluster randomized trial conducted in 31 US pediatric intensive care units (PICUs). A total of 2449 children (mean age, 4.7 years; range, 2 weeks to 17 years) mechanically ventilated for acute respiratory failure were enrolled in 2009-2013 and followed up until 72 hours after opioids were discontinued, 28 days, or hospital discharge. INTERVENTION: Intervention …


Coping With Congenital Hand Differences, L. E. Franzblau, K. C. Chung, N. Carlozzi, A. Y. T. Chin, K. W. Nellans, J. F. Waljee Jan 2015

Coping With Congenital Hand Differences, L. E. Franzblau, K. C. Chung, N. Carlozzi, A. Y. T. Chin, K. W. Nellans, J. F. Waljee

Journal Articles

Background: Although functional outcomes following reconstruction for congenital hand differences are frequently described, much less is known regarding children's ability to cope with the psychosocial effects of these conditions. The authors qualitatively explored stress and coping mechanisms among children following reconstructive surgery for congenital hand differences. Methods: Forty patients and their parents participated in semistructured interviews examining children's stress related to hand functioning and appearance, emotional responses to stress, and coping strategies. Interviews were audiotaped, transcribed, and analyzed thematically. A consensus taxonomy for classifying content evolved from comparisons of coding by two reviewers. Themes expressed by participants were studied for …


Sleep Deficiency And Deprivation Leading To Cardiovascular Disease, M. Kohansieh, A. N. Makaryus Jan 2015

Sleep Deficiency And Deprivation Leading To Cardiovascular Disease, M. Kohansieh, A. N. Makaryus

Journal Articles

Sleep plays a vital role in an individual's mental, emotional, and physiological well-being. Not only does sleep deficiency lead to neurological and psychological disorders, but also the literature has explored the adverse effects of sleep deficiency on the cardiovascular system. Decreased quantity and quality of sleep have been linked to cardiovascular disease (CVD) risk factors, such as hypertension, obesity, diabetes, and dyslipidemia. We explore the literature correlating primary sleep deficiency and deprivation as a cause for cardiovascular disease and cite endothelial dysfunction as a common underlying mechanism.


Health Professions Division Catalog 2015-2016, Nova Southeastern University Jan 2015

Health Professions Division Catalog 2015-2016, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Epidural Steroid Injections Compared With Gabapentin For Lumbosacral Radicular Pain: Multicenter Randomized Double Blind Comparative Efficacy Study, Steven P. Cohen, Steven Hanling, Mark C. Bicket, Ronald L. White, Elias Velzi, Connie Kurihara, Zirong Zhao, Salim Hayek, Kevin B. Guthmiller, Scott R. Griffith, Vitaly Gordin, Mirinda Anderson White, Yakov Vorobeychik, Paul F. Pasquina Jan 2015

Epidural Steroid Injections Compared With Gabapentin For Lumbosacral Radicular Pain: Multicenter Randomized Double Blind Comparative Efficacy Study, Steven P. Cohen, Steven Hanling, Mark C. Bicket, Ronald L. White, Elias Velzi, Connie Kurihara, Zirong Zhao, Salim Hayek, Kevin B. Guthmiller, Scott R. Griffith, Vitaly Gordin, Mirinda Anderson White, Yakov Vorobeychik, Paul F. Pasquina

Neurology Faculty Publications

Objective To evaluate whether an epidural steroid injection or gabapentin is a better treatment for lumbosacral radiculopathy.

Design A multicenter randomized study conducted between 2011 and 2014. Computer generated randomization was stratified by site. Patients and evaluating physicians were blinded to treatment outcomes.

Settings Eight military, Veterans Administration, and civilian hospitals.

Participants 145 people with lumbosacral radicular pain secondary to herniated disc or spinal stenosis for less than four years in duration and in whom leg pain is as severe or more severe than back pain.

Interventions Participants received either epidural steroid injection plus placebo pills or sham injection plus …


Doctorate Of Osteopathic Medicine Overview, Nova Southeastern University Jan 2015

Doctorate Of Osteopathic Medicine Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Genetic Polymorphisms In The Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision, Y. J. Qadri, A. V. Bortsov, D. C. Orrey, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, P. L. Hendry, S. A. Mclean, +1 Additional Author Jan 2015

Genetic Polymorphisms In The Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision, Y. J. Qadri, A. V. Bortsov, D. C. Orrey, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, P. L. Hendry, S. A. Mclean, +1 Additional Author

Journal Articles

Objectives:Dopaminergic signaling is implicated in nociceptive pathways. These effects are mediated largely through dopamine receptors and modulated in part by dopamine transporters. This study tested the hypothesis that genetic variants in the genes encoding dopamine receptor 2 (DRD2) and the dopamine active transporter (SLC6A3) influence acute pain severity after motor vehicle collision.Materials and Methods:European Americans presenting to the emergency department after motor vehicle collision were recruited. Overall pain intensity in emergency department was assessed using a 0 to 10 numeric rating scale. DNA was extracted from blood samples and genotyping of single-nucleotide polymorphisms (SNPs) in the DRD2 and SLC6A3 gene …


Neural Systems Mediating Decision-Making And Response Inhibition For Social And Nonsocial Stimuli In Autism, K. M. Shafritz, J. D. Bregman, T. Ikuta, P. R. Szeszko Jan 2015

Neural Systems Mediating Decision-Making And Response Inhibition For Social And Nonsocial Stimuli In Autism, K. M. Shafritz, J. D. Bregman, T. Ikuta, P. R. Szeszko

Journal Articles

Autism is marked by impairments in social reciprocity and communication, along with restricted, repetitive and stereotyped behaviors. Prior studies have separately investigated social processing and executive function in autism, but little is known about the brain mechanisms of cognitive control for both emotional and nonemotional stimuli. We used functional magnetic resonance imaging to identify differences in neurocircuitry between individuals with high functioning autism (HFA) and neurotypical controls during two versions of a go/no-go task: emotional (fear and happy faces) and nonemotional (English letters). During the letter task, HFA participants showed hypoactivation in the ventral prefrontal cortex. During the emotion task, …


Progressive Reduction In Cortical Thickness As Psychosis Develops: A Multisite Longitudinal Neuroimaging Study Of Youth At Elevated Clinical Risk, T. D. Cannon, Y. Chung, G. He, D. Sun, K. Cadenhead, B. A. Cornblatt, M. Tsuang, E. Walker, S. W. Woods, R. Heinssen, +10 Additional Authors Jan 2015

Progressive Reduction In Cortical Thickness As Psychosis Develops: A Multisite Longitudinal Neuroimaging Study Of Youth At Elevated Clinical Risk, T. D. Cannon, Y. Chung, G. He, D. Sun, K. Cadenhead, B. A. Cornblatt, M. Tsuang, E. Walker, S. W. Woods, R. Heinssen, +10 Additional Authors

Journal Articles

BACKGROUND: Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms have been observed to show a steeper rate of cortical gray matter reduction compared with individuals without symptomatic progression and with healthy control subjects. Whether such changes reflect processes associated with the pathophysiology of schizophrenia or exposure to antipsychotic drugs is unknown. METHODS: In this multisite study, 274 CHR cases, including 35 individuals who converted to psychosis, and 135 healthy comparison subjects were scanned with magnetic resonance imaging at baseline, 12-month follow-up, or the point of conversion for the subjects who developed fully psychotic symptoms. RESULTS: In …


Integrating Palliative Care Into The Care Of Neurocritically Ill Patients: A Report From The Improving Palliative Care In The Icu Project Advisory Board And The Center To Advance Palliative Care, J. A. Frontera, J. R. Curtis, J. E. Nelson, M. Campbell, M. Gabriel, A. C. Mosenthal, D. R. Lustbader, K. J. Brasel, S. P. Weiss, D. E. Weissman, +5 Additional Authors Jan 2015

Integrating Palliative Care Into The Care Of Neurocritically Ill Patients: A Report From The Improving Palliative Care In The Icu Project Advisory Board And The Center To Advance Palliative Care, J. A. Frontera, J. R. Curtis, J. E. Nelson, M. Campbell, M. Gabriel, A. C. Mosenthal, D. R. Lustbader, K. J. Brasel, S. P. Weiss, D. E. Weissman, +5 Additional Authors

Journal Articles

OBJECTIVES: To describe unique features of neurocritical illness that are relevant to provision of high-quality palliative care; to discuss key prognostic aids and their limitations for neurocritical illnesses; to review challenges and strategies for establishing realistic goals of care for patients in the neuro-ICU; and to describe elements of best practice concerning symptom management, limitation of life support, and organ donation for the neurocritically ill. DATA SOURCES: A search of PubMed and MEDLINE was conducted from inception through January 2015 for all English-language articles using the term "palliative care," "supportive care," "end-of-life care," "withdrawal of life-sustaining therapy," "limitation of life …


Development And Preliminary Testing Of Progress: A Web-Based Education Program For Prostate Cancer Survivors Transitioning From Active Treatment, S. M. Miller, S. V. Hudson, S. K. A. Hui, M. A. Diefenbach, L. Fleisher, M. Buyyounouski, C. Denlinger, C. Miyamoto, A. Reese, J. Baman, +6 Additional Authors Jan 2015

Development And Preliminary Testing Of Progress: A Web-Based Education Program For Prostate Cancer Survivors Transitioning From Active Treatment, S. M. Miller, S. V. Hudson, S. K. A. Hui, M. A. Diefenbach, L. Fleisher, M. Buyyounouski, C. Denlinger, C. Miyamoto, A. Reese, J. Baman, +6 Additional Authors

Journal Articles

This formative research study describes the development and preliminary evaluation of a theory-guided, online multimedia psycho-educational program (PROGRESS) designed to facilitate adaptive coping among prostate cancer patients transitioning from treatment into long-term survivorship. Guided by the Cognitive-Social Health Information Processing Model (C-SHIP) and using health communications best practices, we conducted a two-phase, qualitative formative research study with early stage prostate cancer patients (n = 29) to inform the Web program development. Phase 1 included individual (n = 5) and group (n = 12) interviews to help determine intervention content and interface. Phase 2 employed iterative user/usability testing (n = 12) …


Decision-Making Processes Among Prostate Cancer Survivors With Rising Psa Levels: Results From A Qualitative Analysis, M. J. Shen, C. J. Nelson, E. Peters, S. F. Slovin, S. J. Hall, M. Hall, P. C. Herrera, E. A. Leventhal, H. Leventhal, M. A. Diefenbach Jan 2015

Decision-Making Processes Among Prostate Cancer Survivors With Rising Psa Levels: Results From A Qualitative Analysis, M. J. Shen, C. J. Nelson, E. Peters, S. F. Slovin, S. J. Hall, M. Hall, P. C. Herrera, E. A. Leventhal, H. Leventhal, M. A. Diefenbach

Journal Articles

Background. Prostate cancer survivors with a rising prostate-specific antigen (PSA) level have few treatment options, experience a heightened state of uncertainty about their disease trajectory that might include the possibility of cancer metastasis and death, and often experience elevated levels of distress as they have to deal with a disease they thought they had conquered. Guided by self-regulation theory, the present study examined the cognitive and affective processes involved in shared decision making between physicians and patients who experience a rising PSA after definitive treatment for prostate cancer. Methods. In-depth interviews were conducted with 34 prostate cancer survivors who had …


Radionuclide Imaging: Past, Present And Future Outlook In The Diagnosis Of Infected Prosthetic Joints, L. Brammen, C. Palestro, H. Sinzinger Jan 2015

Radionuclide Imaging: Past, Present And Future Outlook In The Diagnosis Of Infected Prosthetic Joints, L. Brammen, C. Palestro, H. Sinzinger

Journal Articles

Objective: A serious complication of joint replacement surgery is infection, which results in prolonged invalidity as well as removal and subsequent re-implantation after lengthy antibiotic therapy. In terms of diagnostic imaging, nuclear medicine has presented several tracers and imaging modalities over the years to be used in prosthetic joint infection. The PubMed/MEDLINE literature database was systematically examined for publications on infection, arthroplasty, joint replacement, prosthetic joint, gallium, labeled leukocytes, sulfur colloid, antimicrobial peptides, Fluorine-18-fluorodeoxyglucose (F-18-FDG), positron emission tomography/computed tomography (PET-CT), and single-photon emission (SPET-CT). This was determined to be a comprehensive review, not a meta-analysis of prosthetic joint infection and …


Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction And Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders, Y. Chung, A. Jacobson, G. He, T. G. Van Erp, S. Mcewen, J. Addington, C. E. Bearden, K. Cadenhead, B. A. Cornblatt, T. D. Cannon, +8 Additional Authors Jan 2015

Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction And Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders, Y. Chung, A. Jacobson, G. He, T. G. Van Erp, S. Mcewen, J. Addington, C. E. Bearden, K. Cadenhead, B. A. Cornblatt, T. D. Cannon, +8 Additional Authors

Journal Articles

A recent prospective longitudinal neuroimaging study of 274 prodromal risk syndrome subjects revealed that those who later developed full-blown psychotic symptoms exhibited accelerated gray matter loss and third ventricle expansion around the time of onset of psychosis. Previous studies also indicate that higher levels of unusual thought content during prodromal states are a significant predictor of psychosis in clinically high-risk youth (CHR). However, the relationship between clinical symptoms and changes in neuroanatomical structure has not been previously examined in the North American Prodrome Longitudinal Study (NAPLS) sample at the atlas level. In this report, we investigated whether symptom severity as …


Objective Identification And Analysis Of Physiological And Behavioral Signs Of Schizophrenia, M. Osipov, Y. Behzadi, J. M. Kane, G. Petrides, G. D. Clifford Jan 2015

Objective Identification And Analysis Of Physiological And Behavioral Signs Of Schizophrenia, M. Osipov, Y. Behzadi, J. M. Kane, G. Petrides, G. D. Clifford

Journal Articles

BACKGROUND: A patient's physical activity is often used by psychiatrists to contribute to the diagnostic process for mental disorders. Typically, it is based mostly on self-reports or observations, and hardly ever upon actigraphy. Other signals related to physiology are rarely used, despite the fact that the autonomic nervous system is often affected by mental disorders. AIM: This study attempted to fuse physiological and physical activity data and discover features that are predictive for schizophrenia. METHOD: Continuous simultaneous heart rate (HR) and physical activity recordings were made on 16 individuals with schizophrenia and 19 healthy controls. Statistical characteristics of the recorded …


Specificity Of Incident Diagnostic Outcomes In Patients At Clinical High Risk For Psychosis, J. R. Webb, J. Addington, D. O. Perkins, C. E. Bearden, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, E. F. Walker, T. H. Mcglashan, S. W. Woods, +4 Additional Authors Jan 2015

Specificity Of Incident Diagnostic Outcomes In Patients At Clinical High Risk For Psychosis, J. R. Webb, J. Addington, D. O. Perkins, C. E. Bearden, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, E. F. Walker, T. H. Mcglashan, S. W. Woods, +4 Additional Authors

Journal Articles

It is not well established whether the incident outcomes of the clinical high-risk (CHR) syndrome for psychosis are diagnostically specific for psychosis or whether CHR patients also are at elevated risk for a variety of nonpsychotic disorders. We collected 2 samples (NAPLS-1, PREDICT) that contained CHR patients and a control group who responded to CHR recruitment efforts but did not meet CHR criteria on interview (help-seeking comparison patients [HSC]). Incident diagnostic outcomes were defined as the occurrence of a SIPS-defined psychosis or a structured interview diagnosis from 1 of 3 nonpsychotic Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition …


Proven Family-Based Interventions In The Treatment Of Pediatric Obesity, Sarah Winter Jan 2015

Proven Family-Based Interventions In The Treatment Of Pediatric Obesity, Sarah Winter

Physician Assistant Scholarly Project Posters

• Childhood obesity continues to be ever expanding.

• This is leading to increasing health care needs and costs.

• Despite numerous interventions, the rates continue to climb.

• The purpose of this study is to identify family-based childhood obesity interventions that are proven to decrease the rates of childhood obesity.

• A literature review explores multiple different family-based childhood obesity interventions.

• The effective interventions are examined closely to discover commonalities between the interventions.

• Family-based interventions that decrease childhood obesity share similar attributes.

• The proven interventions may indicate the need to focus coordination of care with the …