Digital Commons Network^™

ผลของการฝึกแอโรบิกแบบหนักสลับเบาต่อการลดลงของไขมันและพังผืดในตับในผู้ที่มีภาวะน้ำหนักตัวเกินและภาวะอ้วนร่วมกับโรคไขมันพอกตับชนิดที่ไม่ได้เกิดจากแอลกอฮอล์, ปียานิฐ ธนวนิชนาม

Chulalongkorn University Theses and Dissertations (Chula ETD)

ปัจจุบันโรคไขมันพอกตับชนิดที่ไม่ได้เกิดจากแอลกอฮอล์ไม่มียามาตรฐานในประเทศไทยที่ใช้ในการรักษา จึงมักแนะนำให้ปรับเปลี่ยนพฤติกรรม โดยเน้นไปที่การออกกำลังกาย และการควบคุมการรับประทานอาหาร การศึกษาครั้งนี้มี วัตถุประสงค์เพื่อเปรียบเทียบผลของการฝึกแอโรบิกแบบหนักสลับเบา (HIIT) ต่อการลดลงของไขมันและพังผืดใน ตับในผู้ที่มีภาวะน้ำหนักตัวเกินและภาวะอ้วนร่วมกับโรคไขมันพอกตับชนิดที่ไม่ได้เกิดจากแอลกอฮอล์ เป็นระยะเวลา 3 เดือน ในอาสาสมัครเพศชายและเพศหญิง จำนวน 29 คน อายุ 18-60 ปี มีดัชนีมวลกาย 23-34.9 กิโลกรัมต่อเมตร2 แบ่งเป็นกลุ่มทดลอง 15 คน (อายุเฉลี่ย 37.87 ± 7.58 ปี) และกลุ่มควบคุม 14 คน (อายุเฉลี่ย 42.29 ± 9.36 ปี) ทั้ง 2 กลุ่มมีข้อมูลพื้นฐานไม่แตกต่าง โดยกลุ่มทดลองฝึกออกกำลังกายแบบ HIIT ด้วยการปั่นจักรยาน 3 วันต่อสัปดาห์ และทั้ง 2 กลุ่มมีการคุมอาหารเหมือนกัน โดยมีนักกำหนดอาหารคอยควบคุม ผลการศึกษาพบว่า อาสาสมัครทั้ง 2 กลุ่มสามารถลดไขมันพอกตับได้ (HIIT; -23.67 ± 31.51 dB/m (p = 0.01) vs. Control; -20.21 ± 32.91 dB/m (p = 0.04)) แต่ไม่พบความแตกต่างระหว่างกลุ่ม (p = 0.66) และไม่มีการเปลี่ยนแปลงของพังผืดตับในแต่ละกลุ่มและระหว่างกลุ่ม ( all p>0.05) มีเพียงกลุ่มทดลองที่สามารถลดมวลไขมัน (–0.74 ± 1.22 kg, p = 0.03) เปอร์เซ็นไขมัน (-0.69 ± 1.10 %, p = 0.03) visceral fat area (–4.41 …

A Scoping Review Of Workplace Health Promotion Interventions For Chronic Diseases In Australia, Leonie Arnold, Katherine Harris, Victoria Weale

Faculty, Staff and Student Publications

OBJECTIVE: The aim of this study is to systematically chart and summarize the literature pertaining to workplace health promotion (WHP) interventions targeting the five main modifiable lifestyle risk factors for chronic disease, including smoking, nutrition, alcohol, physical activity, overweight/obesity (SNAPO) in Australian workers.

METHODS: A scoping review was performed using the framework of Arksey and O'Malley. MEDLINE, EMBASE, CINAHL, and SCOPUS were searched to identify peer-reviewed publications that evaluated primary or secondary WHP interventions which targeted one or more modifiable risk factor (SNAPO).

RESULTS: A total of fifty-six articles were included in the review. The findings revealed a heterogeneous nature …

Digest Of The Philadelphia College Of Osteopathic Medicine (2023, No. 1), Philadelphia College Of Osteopathic Medicine

PCOM Digest 2020s

The 2023 Vol. 1 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Updates
• Advancing Alumni
• Institutional Heritage: Founders’ Day 2023
• Digest Magazine Anniversary Series: 125 Years Through 125 Stories
• The Longest-Tenured Dean: Kenneth J. Veit, DO ’76, MBA, FACOFP, reflects on his historic distinction
• This Old House: The story of the Tudor Revival-style mansion that was renovated to become an administration building at the heart of the PCOM campus in Philadelphia
• Class Notes

A Mini Review Of What Matters In The Management Of Nas, Is Esc The Best Care?, Enrique Gomez Pomar

Pediatrics Faculty Publications

As the use of opioids and polysubstance by pregnant women has increased over the years, there has also been a sharp increase in cases of neonatal abstinence syndrome (NAS). Classically, infants affected by NAS have been cared for in neonatal intensive care units resulting in an increase of healthcare expenditure and resource utilization as well as separation from the families. Consequently, the Eat, Sleep, and Console (ESC) tool was developed and promoted as a novel method that focuses on maternal/infant dyad during hospital stay while decreasing the use of pharmacological interventions and therefore decreasing the length of stay and healthcare …

Obesity During Adolescence And Feeding Practices During Infancy: Cross-Sectional Study, Reem Sharaf-Alddin, Radhia Almathkoori, Hara Kostakis, Ahmed N. Albatineh, Abdullah Al-Taiar, Muge Akpinar-Elci

Community & Environmental Health Faculty Publications

Background: Breastfeeding is proposed to play a role in reducing the risk of obesity throughout life. Kuwait has an extremely high prevalence of childhood obesity (45% of adolescents are overweight/obese) and extremely low breastfeeding indicators, particularly exclusive breastfeeding. In fact, little is known about the association between breastfeeding and obesity from Kuwait and the broader Middle East.

Aims: To estimate the prevalence of overweight/obesity in female adolescents in Kuwait and assess its association with breastfeeding during infancy.

Methods: This is a cross-sectional study that included 775 girls randomly selected from public and private high schools in Kuwait. The primary exposure …

Prevalence Of Gastrointestinal Symptoms Among Autistic Individuals, With And Without Co-Occurring Intellectual Disability, Calliope Holingue, Danika Pfeiffer, Natasha N. Ludwig, Rachel Reetzke, Ji Su Hong, Luther G. Kalb, Rebecca Landa

Communication Disorders & Special Education Faculty Publications

Gastrointestinal symptoms (GI) are very common among individuals on the autism spectrum. Prior research reports mixed findings regarding whether individuals with autism and co-occurring intellectual disability (ID) have elevated risk of gastrointestinal symptoms relative to individuals with autism alone. GI symptoms can be challenging to assess in individuals with autism spectrum disorder (ASD) and/or ID given challenges with language, communication, and interoception. Prior research has tended to only include individuals with documented presence or absence of GI symptoms or conditions, that is, to exclude observations in which there is uncertainty regarding presence of GI symptoms. Therefore, none of the prior …

Social Determinants Of Chronic Kidney Disease In The Black American Community: A Systematic Review, Addea Coleman

Honors Undergraduate Theses

This systematic review aims to examine the relationship between the social determinants of health that significantly impact the prevalence and progression of chronic kidney disease (CKD) amongst Black Americans. The Black American population has the highest prevalence of CKD in the United States, while concurrently possessing prominent genetic risk factors for this chronic disease. The social determinants: healthcare quality and access (extended to account for health behaviors), social and community context, and economic stability were specifically assessed in this review. Key terms were utilized to search electronic databases PubMed and Web of Science, which yielded 470 unduplicated articles. Twenty-nine articles …

High Cholesterol Diet Induces Sudden Death In Mice With Impaired Reverse Cholesterol Transport, Misa Ito

Theses and Dissertations--Pharmacology and Nutritional Sciences

Unexplained sudden death continues to be a major public health crisis as AHA reports that 1,000 people suffer sudden cardiac arrest each day in the U.S. with only 10% surviving. A number of ongoing challenges hinder to understand the sudden death. Thus, investigating underlined mechanisms of sudden death is urgent. Unexpectedly, I found a high cholesterol diet (HCD)-induced sudden death preclinical model. Although HCD is associated with a higher risk of cardiovascular disease (CVD) and the subendothelial lipoprotein retention theory is well established for atherosclerosis development, these theories cannot explain the sudden death in my model because atherosclerosis and CVD …

Development Of A Community-Based Plan For An Effective Behavioral Intervention To Reduce Childhood Obesity In A Rural Appalachian Community, Jennifer Stacy Wells

Theses and Dissertations--Nutrition and Food Systems

Rural children experience increased rates of obesity and reduced access to specialized weight management facilities, which makes receiving the recommended frequency of care difficult. Clinical-community partnerships, recommended by the American Academy of Pediatrics (AAP) to expand access, have been shown to be a feasible strategy of care delivery. Examination of literature and stakeholder interviews were used to inform the development of a collaborative pediatric weight management program in a rural, Appalachian community. Screening articles as well as intervention articles were reviewed. Outcomes of screening articles reviewed included BMI measures (3), screening practices (7), and referral practices (4). Common outcomes of …

Diagnosis And Management Of Cyclic Vomiting Syndrome, Sara Read

Capstone Showcase

Cyclic vomiting syndrome (CVS) is a chronic and debilitating condition that can be encountered in a multitude of clinical settings. It is classified as a functional gastrointestinal disorder and is often misdiagnosed. Proper identification and management of this condition are crucial to patient care and quality of life. This article reviews the hypothesized etiologies, clinical presentation, and diagnosis of CVS as well as recommendations for management in a variety of settings. As an understudied and underdiagnosed condition, it is important that clinicians have a basic understanding of this disorder.

The Effects Of Sex On Zebrafish Bone Metabolism, Simon Bagatto

Williams Honors College, Honors Research Projects

I investigated the effects of diet and sex on zebrafish bone metabolism. Zebrafish were subjected to either a high-calorie or low-calorie diet over a five-week period. After this diet, zebrafish scales were used to measure alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) enzyme activity with a fluorescent substrate. The enzyme activities were markers of the osteoblasts (ALP) and the osteoclasts (TRAP). These data were compared among sex and diet of the zebrafish using a repeated measures ANOVA statistical test. I also measured the number of resorption lacunae per scale (another indicator of osteoclast activity). The results showed higher TRAP …

The Short- And Long-Term Readmission Of Four Major Categories Of Digestive System Cancers: Does Obesity Or Metabolic Disorder Matter?, Yan Li, Xiaoqin Wu, Yongfeng Song, Peipei Wang, Bofei Zhang, Bingzhou Guo, Ziwei Liu, Yafei Wu, Shanshan Shao, Yiping Cheng, Honglin Guo, Xiude Fan, Jiajun Zhao

Faculty, Staff and Student Publications

Purpose: Patients with digestive system cancers (DSCs) are at a high risk for hospitalizations; however, the risk factors for readmission remain unknown. Here, we established a retrospective cohort study to assess the association between metabolic obesity phenotypes and readmission risks of DSC.

Experimental design: A total of 142,753 and 74,566 patients at index hospitalization were ultimately selected from the Nationwide Readmissions Database (NRD) 2018 to establish the 30-day and 180-day readmission cohorts, respectively. The study population was classified into four groups: metabolically healthy non-obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO). Multivariate Cox …

Distinct Patterns Of Auto-Reactive Antibodies Associated With Organ-Specific Immune-Related Adverse Events, Mehmet Altan, Quan-Zhen Li, Qi Wang, Natalie I Vokes, Ajay Sheshadri, Jianjun Gao, Chengsong Zhu, Hai T Tran, Saumil Gandhi, Mara B Antonoff, Stephen Swisher, Jing Wang, Lauren A Byers, Noha Abdel-Wahab, Maria C Franco-Vega, Yinghong Wang, J Jack Lee, Jianjun Zhang, John V Heymach

Faculty, Staff and Student Publications

UNLABELLED: The roles of preexisting auto-reactive antibodies in immune-related adverse events (irAEs) associated with immune checkpoint inhibitor therapy are not well defined. Here, we analyzed plasma samples longitudinally collected at predefined time points and at the time of irAEs from 58 patients with immunotherapy naïve metastatic non-small cell lung cancer treated on clinical protocol with ipilimumab and nivolumab. We used a proteomic microarray system capable of assaying antibody reactivity for IgG and IgM fractions against 120 antigens for systemically evaluating the correlations between auto-reactive antibodies and certain organ-specific irAEs. We found that distinct patterns of auto-reactive antibodies at baseline were …

School-Based Intervention Impacts Availability Of Vegetables And Beverages In Participants’ Homes, Erin A Hudson, Marissa Burgermaster, Sophia M Isis, Matthew R Jeans, Sarvenaz Vandyousefi, Matthew J Landry, Rebecca Seguin-Fowler, Joya Chandra, Jaimie Davis

Faculty, Staff and Student Publications

As rates of metabolic syndrome rise, children consume too few vegetables and too much added sugar. Because children tend to eat what is available at home, the home environment plays a key role in shaping dietary habits. This secondary analysis evaluated the effects of a school-based gardening, cooking, and nutrition education intervention (TX Sprouts) compared to control on the availability of vegetables, fruit juice, and sugar-sweetened beverages (SSBs) at home. In the TX Sprouts cluster-randomized trial, 16 schools were randomized to TX Sprouts (

The Health-Promoting Effects And The Mechanism Of Intermittent Fasting, Simin Liu, Min Zeng, Weixi Wan, Ming Huang, Xiang Li, Zixian Xie, Shang Wang, Yu Cai

Faculty, Staff and Student Publications

Intermittent fasting (IF) is an eating pattern in which individuals go extended periods with little or no energy intake after consuming regular food in intervening periods. IF has several health-promoting effects. It can effectively reduce weight, fasting insulin levels, and blood glucose levels. It can also increase the antitumor activity of medicines and cause improvement in the case of neurological diseases, such as memory deficit, to achieve enhanced metabolic function and prolonged longevity. Additionally, IF activates several biological pathways to induce autophagy, encourages cell renewal, prevents cancer cells from multiplying and spreading, and delays senescence. However, IF has specific adverse …

Selinexor In Combination With Weekly Paclitaxel In Patients With Metastatic Solid Tumors: Results Of An Open Label, Single-Center, Multi-Arm Phase 1b Study With Expansion Phase In Ovarian Cancer, Shannon N Westin, Siqing Fu, Apostolia Tsimberidou, Sarina Piha-Paul, Fechukwu Akhmedzhanov, Bulent Yilmaz, Lacey Mcquinn, Amanda L Brink, Jing Gong, Cheuk Hong Leung, Heather Lin, David S Hong, Shubham Pant, Brett Carter, Amir Jazaeri, David Gershenson, Anil K Sood, Robert L Coleman, Jatin Shah, Funda Meric-Bernstam, Aung Naing

Faculty, Staff and Student Publications

OBJECTIVE: Selinexor is a first-in-class, oral selective inhibitor of nuclear export (SINE) compound which blocks Exportin-1 (XPO1). Our objective was to determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of selinexor and weekly paclitaxel.

METHODS: This was an open label, single-center, multi-arm phase 1b study utilizing a "3 + 3" design and a "basket-type" expansion in recurrent solid tumors. Selinexor (60 mg or 80 mg twice weekly orally) and weekly paclitaxel (80 mg IV 2 week on, 1 week off) were one of 13 parallel arms. Efficacy was evaluated using RECIST version 1.1.

RESULTS: All 35 patients …

Review Article: New Treatments For Advanced Differentiated Thyroid Cancers And Potential Mechanisms Of Drug Resistance, Sarah Hamidi, Marie-Claude Hofmann, Priyanka C Iyer, Maria E Cabanillas, Mimi I Hu, Naifa L Busaidy, Ramona Dadu

Faculty, Staff and Student Publications

The treatment of advanced, radioiodine refractory, differentiated thyroid cancers (RR-DTCs) has undergone major advancements in the last decade, causing a paradigm shift in the management and prognosis of these patients. Better understanding of the molecular drivers of tumorigenesis and access to next generation sequencing of tumors have led to the development and Food and Drug Administration (FDA)-approval of numerous targeted therapies for RR-DTCs, including antiangiogenic multikinase inhibitors, and more recently, fusion-specific kinase inhibitors such as RET inhibitors and NTRK inhibitors. BRAF + MEK inhibitors have also been approved for BRAF-mutated solid tumors and are routinely used in RR-DTCs in …

Trends And Correlates Of Low Hiv Knowledge Among Ever-Married Women Of Reproductive Age: Evidence From Cross-Sectional Bangladesh Demographic And Health Survey 1996–2014, Md Tariqujjaman, Md Mehedi Hasan, Mohammad Abdullah Heel Kafi, Md Alamgir Hossain, Saad A Khan, Nadia Sultana, Rashidul Azad, Md Arif Hossain, Mahfuzur Rahman, Mohammad Bellal Hossain

Faculty, Staff and Student Publications

BACKGROUND: The human immunodeficiency virus (HIV) burden has frequently been changing over time due to epidemiological and demographic transitions. To safeguard people, particularly women of reproductive age, who can be exposed to transmitting this burden to the next generation, knowledge regarding this life-threatening virus needs to be increased. This research intends to identify the trends and associated correlates of "low" HIV knowledge among ever-married women of reproductive age in Bangladesh from 1996 to 2014.

METHODS: We analyzed data derived from six surveys of Bangladesh Demographic and Health Surveys conducted in 1996, 1999, 2004, 2007, 2011, and 2014. Analyses were primarily …

High Resting Energy Expenditure In Women With Episodic Migraine: Exploring The Use Of Predictive Formulas, Laís Bhering Martins, Jéssica Sales Ribeiro, Ana Maria Dos Santos Rodrigues, Luana Caroline Dos Santos, Antonio Lúcio Teixeira, Adaliene Versiani Matos Ferreira

Faculty, Staff and Student Publications

INTRODUCTION: Migraine is a common and disabling primary headache, and its pathophysiology is not fully understood. Previous studies have suggested that pain can increase humans' Resting Energy Expenditure (REE). However, no previous study has investigated whether the REE of individuals with migraine differs from the general population. Therefore, this study aims to assess whether the REE of women with migraine differs from that of women without headaches. We also tested the accuracy of REE predictive formulas in the migraine patients.

METHODS: This cross-sectional study involves 131 adult women aged between 18 and 65 years, 83 with migraine and 48 without …

Colorectal Surveillance Outcomes From An Institutional Longitudinal Cohort Of Lynch Syndrome Carriers, Gabriel Del Carmen, Laura Reyes-Uribe, Daniel Goyco, Kyera Evans, Charles M Bowen, Jennifer L Kinnison, Valerie O Sepeda, Diane M Weber, Julie Moskowitz, Maureen E Mork, Selvi Thirumurthi, Patrick M Lynch, Miguel A Rodriguez-Bigas, Melissa W Taggart, Y Nancy You, Eduardo Vilar

Faculty, Staff and Student Publications

OBJECTIVE: Lynch Syndrome (LS) carriers have a significantly increased risk of developing colorectal cancer (CRC) during their lifetimes. Further stratification of this patient population may help in identifying additional risk factors that predispose to colorectal carcinogenesis. In most LS patients CRC may arise from adenomas, although an alternative non-polypoid carcinogenesis pathway has been proposed for

DESIGN: We collected demographics, genetic, colonoscopy, and pathology results from a total of 163 LS carriers who obtained regular screening care at MD Anderson Cancer Center. Data were extracted from the electronic health records into a REDCap database for analysis. Logistic regressions were performed to …

An Online Intervention To Improve The Health And Well-Being Of Informal Caregivers Of Individuals With Alzheimer's Disease: A Pilot Study, Yujun Liu, M. Courtney Hughes, Abby Baumbach, Lily Derain

Faculty Articles, Papers, and Other Scholarship

Objective: Describe an intervention to improve the health and well-being of informal caregivers of individuals with Alzheimer's disease (AD) and present pilot program findings.

Methods: Participants (N = 31, mean age = 45.7) were randomly assigned to one of two conditions: an online synchronous didactic lesson and peer support session series or an asynchronous didactic only session series. Outcome variables included physical health, nutrition intake, and stress. One-way ANOVA was conducted to examine the effects of the intervention. The least significant difference (LSD) post hoc test was used to analyze the difference pattern between means.

Results: Participants in both conditions …

Omega-3 Polyunsaturated Fatty Acid Levels In Maternal And Cord Plasma Are Associated With Maternal Socioeconomic Status, Alexandra Hergenrader, Matthew Van Ormer, Rebecca Slotkowski, Maranda Thompson, Alyssa Freeman, Olivia Paetz, Sarah Sweeney, Lauren Wegner, Khadijjta Ali, Nicole S. Bender, Ridhi Chaudhary, Melissa K. Thoene, Corrine K. Hanson, Ann Anderson-Berry

Journal Articles: Pediatrics

Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) play a crucial role in fetal growth and neurodevelopment, while omega-6 (n-6) PUFAs have been associated with adverse pregnancy outcomes. Previous studies have demonstrated that socioeconomic status (SES) influences dietary intake of n-3 and n-6 PUFAs, but few studies have evaluated the association between maternal and cord plasma biomarkers of PUFAs and socioeconomic markers. An IRB-approved study enrolled mother-infant pairs (n = 55) at the time of delivery. Maternal and cord plasma PUFA concentrations were analyzed using gas chromatography. Markers of SES were obtained from validated surveys …

Forced Expiratory Volume In The 6 S And Forced Expiratory Volume In The 1 S/Forced Expiratory Volume In The 6 S For Early Detection Of Airflow Obstruction, Therese S. Ghatas, Moheb W. Elfaizy

Journal of Medicine in Scientific Research

Introduction

Use of affordable and simple tools for screening chronic obstructive pulmonary disease (COPD) is limited. In recent years, measurement of forced expiratory volume in the 6 s (FEV6) has been researched as a substitute to replace forced vital capacity measurements. This work was performed to analyze the effectiveness of a simplified handheld forced expiratory flowmeter device and to search an optimal cutoff value of FEV1/FEV6 to detect airflow narrowing and limitation.

Patients and methods

This was a cross-section study for screening and finding of active case among undiagnosed patients with COPD using a simple handheld spirometry device, and the …

Incidence And Severity Of Pulmonary Hypertension Among Patients With Chronic Kidney Disease, Mamdouh Maher

Journal of Medicine in Scientific Research

Chronic kidney disease (CKD) is a major health problem and is closely linked with cardiovascular disease. Pulmonary hypertension (PH) is considered a common comorbidity in CKD patients. In all, 100 patients were included in our study. Transthoracic echo Doppler study was performed to measure pulmonary artery systolic pressure based on tricuspid jet. The prevalence of PH in CKD patients in our study was 60%; prevalence and severity had significant association.

The hemodialyzed group showed a higher prevalence of PH with a more severe PH.

Our study had provided evidence that PH is a common comorbidity in CKD patients and is …

An Analytical Study Of The Risk Factors Affecting The Platelet Aggregation In Patients With Sepsis, Vishnu Priya, Jitender M. Khunger, Anupma Arora

Journal of Medicine in Scientific Research

Objectives (a) To determine the correlation of platelet count and aggregation with sepsis severity and (b) to find the risk factors affecting the platelet aggregation in sepsis. Patients and methods The present observational cross-sectional study was conducted on 30 patients of sepsis over a period of 18 months. All patients underwent complete blood counts, and platelet aggregation to ADP. Pearson correlation coefficient was used to assess the association of Sequential Organ Failure Assessment (SOFA) score and aggregation to ADP and platelet. Linear regression was done to determine the risk factors affecting platelet aggregation in sepsis. A P value of less …

Effectiveness Of Management Program Of Chronic Functional Constipation In Children Who Are Attending The Pediatric Gastroenterology Clinic At Elbeheira Specialized Children's Hospital, Hamouda E. El-Gazzar, Sabreen Ahmed Ali Elsaka, Eman Adel Elsaid Elhaddad

Journal of Medicine in Scientific Research

Background: A chronic constipation is one of the most common functional gastrointestinal complaints in pediatric outpatient clinics. The prevalence of childhood constipation in the general population ranges widely from 0.7% to 29.6% internationally. Pediatric Gastroenterology Clinic at Elbeheira specialized children's Hospital is a referral center from the whole governorate. Objectives: To evaluate the current approach to management, risk factors associated, and clinical characteristics, the challenge of functional constipation in the pediatrics who are attending the Pediatric Gastroenterology Clinic at Elbeheira Specialized Children's Hospital. Methods: This retrospective study was conducted in Pediatric Gastroenterology Clinic at Elbeheira Children's Specialized Hospital for 6 …

Prevalence Of Upper Limb Musculoskeletal Abnormalities In Type 2 Diabetic Patients And Its Relation To Glycemic Control And Associated Factors, Eslam Elsayed Ali Shohda, Amal Emam El-Maghraby, Hadeer Khaled Youssef Elhamid

Journal of Medicine in Scientific Research

Aim of the study: to investigate the prevalence of upper limb musculoskeletal abnormalities and their correlations to glycemic control and associated factors. Methods: A cross-sectional study was conducted at diabetes unit and internal medicine outpatient clinic at Al-ahrar teaching hospital, Zagazig, Egypt. 200 type 2 diabetic patient (T2DM) and 200 non-diabetic control patients of ages > 18 years were enrolled. Rheumatological diseases were excluded. Studied upper limb musculoskeletal abnormalities were Limited joint mobility (LJM), Dupuytren’s contracture (DC), Trigger finger (TF), De Quervain’s tenosynovitis (DQT), Lateral epicondylitis (LE), Medial epicondylitis (ME), Rotator’s cuff tendinitis (RCT) and Carpel tunnel syndrome susceptibility diagnosed by …

Assessment Of Carotid Intima-Media Thickness And Its Relation To Cardiovascular Risk Factors In Obese Children, Faten A.A. Fathi, Somaya M. Abd El Ghany, Ahmed A.H. Taha, Gihan F.A. Hassan, Eman Fouad

Journal of Medicine in Scientific Research

Background Childhood obesity is one of the most critical public health problems today. This study aims to assess the relation between carotid intima-media thickness (CIMT) and cardiovascular risk factors in obese children. Patients and methods This is a case–control study conducted on 80 Egyptian children aged 6–18 years; 40 children with simple obesity as defined by WHO (2011) and 40 healthy children age matched and sex matched were taken as a control group. Cases were selected from the National Nutritional Institute randomly from December 2017 to March 2018. All patients and control groups were subjected to the following: full history …

Assessing Serum Ferritin Together With Some Inflammatory Biomarkers In Overweight And Obese Hospital Care Workers At Elgalaa Teaching Hospital And Its Correlation With Metabolic Syndrome, Sahar Mohamed Said Elbayoumi, Hanan Farouk, Heba Abdelaziz

Journal of Medicine in Scientific Research

Obesity is known to be associated with elevated levels of inflammatory markers. One of the major problems associated with morbidity and mortality. The aim of the study was to assess the posing effect of obesity on the levels of serum ferritin, total cholesterol, HDL and LDL, triglycerides, HBA1C, CRP, and Uric acid with CBC, on random well-being colleague females. Patient and methods: 100 adult female health workers were categorized into three entities according to both BMI and waist circumference, as normal, overweight, and obese. Results: increased serum ferritin as an inflammatory marker might correlate to BMI, in juniors; and might …

Community-Acquired Pneumonia Among Hospitalized Children: Risk Factors, Characteristics, And Outcomes, Marwa Taha, Hanaa Abdel-Wahab

Journal of Medicine in Scientific Research

Background Community-acquired pneumonia (CAP) represents one of the main causes of mortality and morbidity among under-five children worldwide. More than 75% of these fatalities are caused by severe pneumonia. Objectives to identify the potential risk factors associated with severe CAP among under-five children hospitalized with CAP. Patients and Methods This prospective observational study was conducted on children, aged 1 to 59 months, who were admitted with CAP to the Department of Pediatrics, Mataria Teaching Hospital, Egypt. Based on World Health Organization (WHO) guidelines, patients were classified into two groups; CAP and severe CAP. Data including demographic, children's history, clinical assessment, …