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A Method Of Studying Leukocytic Functions In Vivo, John W. Rebuck, James H. Crowley

Henry Ford Hospital Medical Journal

No abstract provided.

A Method For Evaluating The Platelet Surface Response By Using Electron Microscopy, Jeanne M. Riddle

Henry Ford Hospital Medical Journal

Our method for evaluating the surface response of any given platelet population, which has evolved over the past two decades, provides a measure of both the adhesive and cohesive qualities of platelets. General morphologic features of the adherent, whole platelets can be assessed by transmission electron microscopy, and the results are reproducible when serial samples are collected on normal subjects and patient groups. With this technique, different metabolites and drugs can be combined with platelet populations that are either normoresponsive or hyperactive to determine if these substances trigger or inhibit the platelet response. To date, the results from in vitro …

Contributions Of Electron Microscopy To The Study Of Platelets, J. W. Rebuck, Jeanne M. Riddle, S. A. Johnson, R. W. Monto, Ruth M. Sturrock

Henry Ford Hospital Medical Journal

No abstract provided.

Functional And Biochemical Alterations Of Platelets In Atherosclerosis And Thromboembolism, Orhan N. Ulutin

Henry Ford Hospital Medical Journal

In atherosclerosis, platelets appear to circulate in an activated state. Our findings are based on results obtained from 240 patients. These platelets demonstrated an increased degree of surface activation and an increased amount of aggregation. Platelet aggregation was also demonstrated by a heightened sensitivity to adrenalin and ADP. Greater than normal secretion of ADP, PF-4, platelet fibrinogen, and platelet antiplasmin was noted. Platelet antiplasmin was increased, whereas platelet antithrombin III was decreased. Membrane transport of glucose was found to be defective in atherosclerosis. There appears to be no alteration in the phospholipid distribution, although the amount of phospholipids increases. The …

Vital Signs, September, 1979, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

The Role Of Exercise And Nutrition In The Rehabilitation Of The Geriatric, Robert R. Ladd

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract not included]

Detection Of Unique Tumor-Associated Proteins In The Urine Of Patients With Transitional Cell Carcinoma By High Resolution Two-Dimensional Polyacrylamide Gel Electrophoresis, Robert David Lehman

Biological Sciences Theses & Dissertations

A two-dimensional polyacrylamide gel electrophoretic technique was developed for the detection of unique tumor-associated proteins in urine of patients with transitional cell carcinoma (TCC) of the urinary bladder. This technique yielded high resolution of polypeptides in the urine of cancer patients. Urine was chosen as a source of tumor-associated components because the location of the tum or should release already solublized tum or substances in to the urine.

Urinary proteins were concentrated and then analyzed by the two - dimensional electrophoretic technique using isoelectric focusing in the first dimension and sodium dodecylsulfate - polyacrylamide gel electrophoresis in the second dimension. …

Percutaneous Transfemoral Renal Artery Occlusion In The Management Of Advanced Renal Carcinoma, Douglas E. Johnson

Henry Ford Hospital Medical Journal

This report describes renal artery occlusion as a therapeutic alternative to nephrectomy and chemotherapy in treating patients with metastatic renal carcinoma. Using a combination of Gelfoam and the Gianturco stainless steel coil, embolization was performed on 75 patients at the University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute with promising results. Its use is recommended 1) to facilitate surgical removal of large and difficult tumors, 2) to control local symptoms (pain, bleeding, etc), and 3) as part of a planned therapeutic program consisting of infarction, nephrectomy and progestins for patients with minimal to moderate metastatic disease.

Management Of Renal Cell Carcinoma: Evaluation Of Renal Masses By Modem Radiological Techniques, W. R. Eyler, M. A. Sandler, S. C. Cross, B. L. Madrazo

Henry Ford Hospital Medical Journal

The utilty of ultrasound and computed tomography is compared to angiography and that of nephrotomography in the study of renal masses. Ultrasound and computed tomography, noninvasive methods, are replacing nephrotomography and, in some cases, angiography

Isolation Of An Acid-Fast Organism From The Aqueous Humor In A Case Of Sarcoidosis, C. L. Barth, M. S. Judge, L. H. Mattman, P. C. Hessburg

Henry Ford Hospital Medical Journal

The anterior chamber fluid from the eye of this patient with sarcoidosis was found to contain microcolonies of a cellwall-deficient organism that was propagated and identified as acid-fast by the Intensified Acid-Fast stain. The colonies were inoculated into mice and retrieved from the dead or sacrificed animals. This report suggests that the acid-fast microbe in the aqueous humor of this case of uveitis-sarcoidosis may be the same organism as that found in the blood in sarcoidosis. Thus, it may be associated not only with the primary disease, but also with the complications of Boeck's sarcoidosis.

1978 Publications Of The Staff Of Henry Ford Hospital

Henry Ford Hospital Medical Journal

No abstract provided.

The Effect Of Escherichia Coli Endotoxin On The Cat Periapical Tissues, Thomas G. Dwyer

Loma Linda University Electronic Theses, Dissertations & Projects

The periapical tissue reaction to three concentrations of endotoxin solutions and to a sterile saline control solution was examined in six adult cats. The maxillary and mandibular cuspids were isolated and the pulps extirpated with barbed broaches. The four solutions (1, 10, 100 μg/ml endotoxin, and saline) were then injected into the four prepared teeth for each cat and the access cavities sealed with IRM.

At two week intervals, two cats were sacrificed and the specimens removed, while the remaining animals were retreated as previously described. The block tissue sections were radiographed, fixed in 10% buffered formalin, and prepared for …

Vital Signs, May, 1979, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Cell Mediated Immunity By Cytotoxicity Assay And The Effect Of Corynebacterium Parvum And Radiation On Mice Bearing Herpes-Induced Tumors, Robert B. Stagg

Loma Linda University Electronic Theses, Dissertations & Projects

Cell mediated immune (CMI) cytotoxic reactivity of Balb/c mice against H238 cells, a Herpes simplex virus (HSV) Type 2 - induced sarcoma, was measured by the ¹²⁵IUdR release assay. The Balb/c mouse response to the growing HSV-induced tumor, treated with radiation and , was measured by survival rate, tumor growth and immune cytotoxicity of spleen and peritoneal exudate cells (PEC) as determined by ¹²⁵IUdR release assay. Subcutaneous (s.c.) inoculation of 1 x 10⁶ H238 cells (high dose) produced progressive tumor growth while s.c. inoculation of 1 x 10⁴ H238 cells (low dose) produced no tumors. A …

Newsletter, Volume 24, Number 01, January - February 1979, Theodore Mclemore Phd, Marilyn Arnott Phd, Myles Mace Phd, Russell Martin Md

Newsletter: A Report to Physicians of Texas Archives

• Phagocytosis of Asbestos Fibers
• The Noninvasive Cardiac Laboratory
• Sexual Rehabilitation Seminar to be Held
• Agricultural Agents’ Training Program
• Intra-arterial Infusion for Metastatic Liver Cancer
• MDAH Referral Guide
• Drs LeMaistre and Drane Honored
• Tamoxifen in the Treatment of Metastatic Breast Cancer

In Vitro And Clinical Studies Of Cefaclor, A New Cephalosporin, Daria Kiani, Tom Madhavan, Keith Burch, Don Pohlod, Evelyn Fisher, Edward L. Quinn

Henry Ford Hospital Medical Journal

In vitro susceptibility studies of 246 clinical isolates demonstrated that this antibiotic was effective against Group A beta hemolytic streptococci, alpha hemolytic streptococci, S. pneumoniae, both penicillinase producing and nonpenicillinase producing Staphylococci, Klebsiella pneumoniae, and Proteus mirabilis. Cephalothin susceptible E. coii were also susceptible to cefaclor. Pseudomonas aeruginosa, Serratia sp., Enterobacter Sp., and Streptococcus faecalis were uniformly resistant to cefaclor. The efficacy and safety of this antibiotic were studied in 27 patients with urinary tract, soft tissue, and respiratory infections. Patients with urinary tract infections became abacteriuric after 48 hours. Patients with soft tissue infections responded well within the first …

A Comparison Of Kidney Preservation Methods By Oxidative Phosphorylation Studies, Devprakash Samuel, Stanley G. Dienst

Henry Ford Hospital Medical Journal

An oxygen consumption assay using adenosine diphosphonucleotide (ADP) was performed on canine kidneys to measure the efficiency of oxidative phosphorylation. The purpose of the assay was to establish a respiratory control index (RCI) that could be used to evaluate kidneys preserved by different methods. Of the four methods tested, perfusion yielded the best results after 24-hour preservation. Additionally, four pairs of human cadaver kidneys were evaluated with the same assay. Some correlation existed between the RCI values of the nontransplanted kidney in each pair and the clinical viability of its transplanted mate.

Vital Signs, June, 1978,, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1978), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1978 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• The President's Page
• Opening of the School of Allied Health
• Lecturers at College
• Faculty Notes
• People
• Nursing Alumnae
• Alumni News Briefs
• Class of '28
• Meet the Board of Trustees
• News from the College
• News from the Hospital and Health Care Centers
• Hospital Week 1978
• New Appointments
• Sports at PCOM
• Alumni Meetings
• In Memoriam
• Continuing Medical Education Calendar

Studies On Uveitis Part Ii: Hypotheses With Case Reports, Philip C. Hessburg

Henry Ford Hospital Medical Journal

A number of patients with and without uveitis are used to show that this study of aqueous microbiology suggests the following hypotheses: 1. Routine techniques currently used in most microbiology laboratories overlook classical and variant bacteria which might be isolated from clinical specimens with improved microbiological techniques. 2. Bacterial forms may be present in other ocular tissue when not present in the aqueous. 3. Polymicrobial infections probably occur rather frequently, especially in chronic or subacute inflammatory states. 4. Alterations in various host factors may subject some persons to a greater incidence of inflammatory episodes including uveitis. 5. Antibiotics used in …

The Quantitative Determination Of 3-Oxo-Bile Acids, W. T. Beher, G. J. Lin, J. Sanfield, S. Stradnieks

Henry Ford Hospital Medical Journal

A new method for the rapid quantification of 3-oxo-bile acids has been developed. From 5 to 120 μg of oxo-acid in aqueous or ethanolic media are reduced with sodium borohydride. The resulting 3α- and 3β-hydroxy acids are then oxidized in a reaction catalyzed by 3-hydroxysteroid dehydrogenase, during which nicotinamide adenine dinucleotide (NAD) is reduced to NADH. The absorbance of the reaction mixture is determined at 340 nm and is directly proportional to the amount of 3-oxo-acid in the original sample. The method is fully compatible with that used in determining 3α-hydroxy-bile acids.

Studies On Uveitis Part I: Aqueous Studies, Philip C. Hessburg

Henry Ford Hospital Medical Journal

Aqueous microbiological and cytological studies were performed on 134 anterior chamber taps done on 118 patients both with and without uveitis. Cell wall defective bacterial forms (CWDF) were recovered from about 40% of these aqueous specimens and classical bacteria were recovered from 12%. A statistically significant difference could not be found between the incidence of bacterial cell wall defective forms in the various anatomical types of uveitis. There were hints from this work that the presence of CWDF In the aqueous was more frequent in younger patients with uveitis, early in the uveitis attack, if there were multiple foci of …

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1977-1978), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1977-1978 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• The President's Page
• Founders Day
• Officers of Alumni Association
• Class Reunions
• Challenge for the Next Hundred Years
• Employee Recognition Dinner
• Meet the Board of Trustees
• New Appointments
• Alumni News Briefs
• Board of Trustees News Briefs
• General Practice Certification
• News from the College
• News from the Hospital and Health Care Centers
• People - Ray McCollough D.O. '28
• Christmas at PCOM
• Faculty Notes
• In Memoriam

Vital Signs, December, 1977, Boonshoft School Of Medicine

Vital Signs

A six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

The Water-Soluble Contrast Medium Lumbar Myelogram And Its Surgical Correlations, Henri C. Labasse

Henry Ford Hospital Medical Journal

The water-soluble contrast medium lumbar myelogram is a very helpful tool in the diagnosis of herniated nucleus pulposus (EfNP) in patients who suffer unilateral root pain of mechanical course. One can often make the differential diagnosis between a ruptured disc and a protruding disc. Unless the disc fragment lies way out in the intervertebral foramen, the myelogram will show some kind of anomaly. Therefore, fewer exploratory operations will be performed on patients having normal myelograms. Metrisamide, a newcomer among the water-soluble contrast media, is nontoxic for the spinal cord. Therefore, if the usual myelogram is normal and one fears a …

Selective Cerebral Arteriography And The Cat Scan In Acoustic Tumors, Donald C. Austin

Henry Ford Hospital Medical Journal

Increasing experience with selective cerebral arteriography in the diagnostic evaluation of acoustic tumors has led to a more rational determination of the proper surgical approach to the lesion. It also predicts the necessity for staging the surgical procedure, reduces the potential for intraoperative complications and rules out other types of angle lesions and the possible necessity for performing a preoperative, concomitant or postoperative shunting procedure. The CAT scan has added an important screening procedure in predicting the presence of an angle lesion, determining the need for further diagnostic studies and evaluating the possible presence or absence of a recurrent tumor …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1977), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1977 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• The President's Page
• We're Expanding
• The First Day
• Convocation
• Open House
• News from the College
• News from the Hospital and Health Care Centers
• Meet the Board of Trustees
• An Interview with Emanuel Fliegelman, D.O.
• Alumni News Briefs
• New Appointments
• People - Charles Hillyer, D.O.
• Board of Trustees News Briefs
• Faculty Notes
• In Memoriam

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1977), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1977 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Commencement
• Commencement Speaker
• Commencement Dinner
• Awards
• News from the College
• Alumni Fund Report
• Promotions and Appointments
• New Appointments
• Faculty Notes
• Alumni News Briefs
• News from the Hospital
• Highlights of EROC
• Class of 1977
• CME Calendar
• In Memoriam

Xeroradiography & Conventional Radiography : Comparative Imaging Of The Temporomandibular Joint, Nelson R. Gatov

Loma Linda University Electronic Theses, Dissertations & Projects

An investigation was conducted to evaluate the application of Xeroradiography for imaging the Temporomandibular Joint using the Updegrave and Weinberg positioning boards and to compare these images to those obtained by conventional radiography using the same positioning boards.

A cadaver head in which three spherical radiopaque implants had been placed was used in this study. A General Electric Model 1000 (Dental Unit) was the source of radiation. The conventional radiographs were produced on Dupont Cronex 2DC film and processed by a Phillips 810 automatic processed by a Xerox "125 System".

MAGNIFICATION

A comparison of the implant sphere diameters and the …

Apical Closure Induction Using Bone Growth Factors And Mineral Trioxide Aggregate, Kenneth W. Tittle

Loma Linda University Electronic Theses, Dissertations & Projects

This study compared the ability of three different bone growth factor combinations with that of Ca(OH)₂ to stimulate apical closure as well as the effectiveness of Mineral Trioxide Aggregate (MTA) as an apical barrier. Fifty-six roots of second and fourth mandibular premolars of seven six- month old beagle dogs were used. Periradicular lesions were created over a four week period. The canals were cleaned and shaped and filled with Ca(OH)₂ for one week. They were then irrigated and received one of seven different treatments in a balanced design. Growth factors were placed in a carboxymethylcellulose carrier and delivered …