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Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1982-1983), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1982-1983 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• The Many Sides of Dr. Guest
• 1983 Founders Day/Alumni Weekend
• Reflections on Yesterday
• The Cathie Museum
• Remembering Dr. Cathie
• The Reunion Scrapbook
• Flounders Day Follies
• Saluting the OMCP's Employees
• New Emphasis on Child Restraints
• Appointment
• Worth Mentioning
• News from the OMCP
• Faculty Notes
• Alumni News Briefs
• In Memoriam

Immunological Involvement In Porcine Bioprosthetic Valve Degeneration: Preliminary Studies, Rollin H. Heinzerling, Paul D. Stein, Jeanne M. Riddle, Donald J. Magilligan Jr., John J. Jennings

Henry Ford Hospital Medical Journal

Preliminary animal model studies have indicated that porcine bioprosthetic valves can be recognized by the immune system. This report presents the results of a preliminary investigation on the implanted valves of 27 patients. While none of the 27 demonstrated an immune response to porcine serum proteins, five patients developed antibodies against the implanted valve leaflets. Cells were enzymatically eluted from a degenerated bioprosthetic valve and were classified by means of monoclonal antibodies. Although these cells were not found to be of T-lymphocyte lineage, they did express la determinants and had the morphologic appearance of plasma cells. We therefore conclude that …

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1982), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1982 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Commencement
• Commencement Families
• Honorary Degree Recipient
• Master of Science
• Pre/Post Commencement
• Commencement Dinner
• Awards
• Class of 1982
• Class of 1982 Internships
• $4 Million Capital Campaign Special Section
• Hospital Honors Graduating House Staff
• Volunteers Honored
• Osteopathic Discovery
• Faculty Notes
• News from the OMCP
• News from the Alumni Office
• Alumni News Briefs
• In Memoriam

Isoenzyme Update: Creatine Kinase And Lactate Dehydrogenase, Craig C. Foreback

Henry Ford Hospital Medical Journal

Creatine kinase (CK) and lactate dehydrogenase (LD) are isoenzymes that have been measured in clinical laboratories for over 20 years; their separation has proved valuable in the diagnosis of myocardial infarction and other cardiac-related diseases. Although, historically, electrophoresis was the preferred method to measure both isoenzymes, there has been controversy over the best method for separating the CK isoenzyme. lon exchange chromatography has been used successfully to isolate CK isoenzymes, and the procedure was adapted to determine CK-MB activity in serum. New methods to quantify CK-MB have also been tested, including an automated column technique, the immunoinhibidon/ immunoprecipitadon technique, and …

Vital Signs, Spring 1982, Boonshoft School Of Medicine

Vital Signs

A seven page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1982), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1982 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Philadelphia's Tricentennial
• An Era Ends
• Housecalls Take him back in Time
• Program Provides Chance of a Lifetime
• New Facilities at the OMCP
• News from the OMCP
• Faculty Notes
• Nurses' Reunion
• In Memoriam
• News from the Alumni Office
• Alumni News Briefs
• College Honors Its Athletes

The Immunology Of Inflammatory Bowel Disease, Hugh L. N. Mackechnie

Henry Ford Hospital Medical Journal

Although several measurements of both cellular and humoral immunity are altered in inflammatory bowel disease (IBD), no direct pathogenic role can be confirmed in either ulcerative colitis (UC) or Crohn's disease (CD). No clear role has been shown for allergic, microbiological, or psychogenic factors, and no specific genetic susceptibility has been demonstrated. Several studies have shown some benefit from using immunosuppressive drugs to treat inflammatory bowel disease, such as sulfasalazine to treat ulcerative colitis and corticosteroids to treat Crohn's disease. Whether these benefits derive from the anti-inflammatory activity of these drugs or from their immunological effects is uncertain.

Vital Signs, February 1982, Boonshoft School Of Medicine

Vital Signs

A six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Effects Of Various Hormones On Human Carcinoma Cell Proliferation, Y. L. Gao, B. S. Leung, A. H. Potter, W.C.Y. Yu

Journal of the Minnesota Academy of Science

Cell proliferation of a mammary adenocarcinoma cell line, CAMA-1. is affected by a number of steroid hormones and prolactin in long-term cultures. Estrogenic compounds stimulate cell growth while antiestrogenic compounds inhibit it. Prolactin can synergize the estrogenic effect. Progesterone, glucocorticoid or androgen reduce cell proliferation. Dihydrotestosterone is a very potent inhibitor,- effective at as low as 10 nM, and its effect is independent of estrogen action. Cortisol is a less effective inhibitor at concentrations below 10 nM; at these levels cortisol exhibits a slight inhibition which appears to be unrelated to estrogenic action. However, at higher concentrations, cortisol markedly reduces …

Vaginal Colonization With Staphylococcus Aureus In Healthy Women: A Review Of Four Studies, Mary Guinan, Bruce B. Dan, Richard J. Guidotti, Arthur L. Reingold, George P. Schmid, Elena J. Bettoli, Joseph G. Lossick, Kathryn N. Shands, Mark A. Kramer, Nancy T. Hargrett, Roger L. Anderson, Claire V. Broome

School of Public Health Faculty Research

Four studies assessed the frequency of vaginal Staphylococcus aureus colonization in healthy women and associated risk factors. An association was found between S. aureus vaginal colonization and colonization at the labia minora and the anterior nares. Significant risk factors associated with an increased risk of vaginal S. aureus in at least one study were a history of genital herpes simplex infection, insertion of tampons without an applicator, and the use of Rely (Procter & Gamble) tampons. The use of systemic antibiotics within 2 weeks of the vaginal culture decreased the risk of recovery of S. aureus. The overall frequency …

The Effect Of Theophylline On Intestinal Bicarbonate Transport Measured By Ph Stat In Amphiuma, Michael A. Imon, John F. White

Department of Anesthesia Faculty Articles

1. The influence of theophylline on the mucosa to serosa and serosa to mucosa fluxes of HCO3- were measured by the pH stat technique in isolated segments of proximal small intestine from Amphiuma maintained under short-circuited conditions. The mucosal or serosal fluid was exposed to media containing 25 mM-HCO3- (pH 7.4) while the pH of unbuffered media in the opposite compartment was maintained by addition of acid. 2. Theophylline significantly increased the secretory flux of HCO3- and significantly reduced the absorptive flux when measured in Cl- -free (SO4(2-)) media. 3. In normal media theophylline did not alter the secretory flux …

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1981-1982), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1981-1982 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Founders Day/Alumni Weekend
• Reunions
• From the Archives
• Flounders Day Follies
• School of Allied Health Graduation
• People
• Faculty Notes
• News from the OMCP
• Worth Mentioning
• New Appointments
• News from the Alumni Office
• Alumni News Briefs
• In Memoriam

Behcet's Syndrome: Case Report And Literature Review, K. V. Venkatasubramaniam, Douglas R. Swinehart

Henry Ford Hospital Medical Journal

Behcet's syndrome is a disease commonly found in Japan and in countries around the Mediterranean Sea. In the U.S., it is relatively uncommon. This report describes a 24-year-old Lebanese-American man with Behcet's syndrome who presented with symptoms four months after he developed arthritis and who had been initially diagnosed as having incomplete Reiter's syndrome. A literature review is Included.

Survey Of Pediatricians : What Are The Criteria Used For Referral To Speech And Language Pathologists?, Janet Bradley

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of the present research was to summarize from the pediatric literature the norms for speech and language development and to determine if the pediatrician is utilizing these norms as criteria for making referrals to speech and language pathologists. Research tends to show a discrepancy between the incidence of speech and language disorders and the rate of referrals made by physicians.

The methodology involved developing a three-part questionnaire to determine what screening instruments are being used in the pediatric office in regard to speech, language, and hearing, and what informal criteria are utilized for making referrals for a speech …

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1981), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1981 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Commencement
• Honorary Degree Recipient
• Master of Science
• Commencement Dinner
• Awards
• Class of 1981 Internships
• Class of 1981
• News from the Hospital
• News from the College
• Faculty Notes
• News from the Division of Special and Continuing Education
• New Appointments
• News from the Alumni Office
• Alumni News Briefs
• In Memoriam
• Founders Day Schedule

Intestinal Bicarbonate Secretion In Amphiuma Measured By Ph Stat In Vitro: Relationship With Metabolism And Transport Of Sodium And Chloride Ions, Michael A. Imon, John F. White

Department of Anesthesia Faculty Articles

1. Isolated Amphiuma small intestine exposed on both surfaces to buffered or unbuffered media generated gradients of pH under short-circuited conditions consistent with secretion of HCO3(-). 2. When unbuffered mucosal medium was maintained at pH 7.4 by addition of acid, alkalinization of the mucosal medium occurred at a rate of 1-2 microequiv/hr cm2 under short-circuit conditions (Isc) and was reduced by anoxia, acetazolamide or removal of CO2. 3. The rate of HCO3(-) secretion (JHCO3(-)) was reduced at a mucosal pH above or below 7.4 and was proportional to serosal HCO3(-). 4. JHCO3(-) was reduced in Na+-free (choline) and Cl-free (SO4(2-) …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1981), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1981 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Report of the Capital Campaign
• Neurosensory Diagnostic Center
• Faculty Notes
• News from the College
• News from the Hospital
• Tour of 4190
• Nurses Alumnae Banquet
• Bookstore
• Synapsis '82
• Spring Sports
• Worth Mentioning
• New Appointments
• From the Alumni Office
• Alumni News Briefs
• In Memoriam
• Founders Day Schedule

Vital Signs, March 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Role Of The Arachidonic Acid Metabolites, Thromboxane A2 And Prostacyclin, In Shock Induced By Intraabdominal Sepsis, Robert Raymond Butler

MUSC Theses and Dissertations

A rat fecal peritonitis model of acute intraabdominal sepsis was investigated in order to evaluate the potential role of arachidonic acid metabolites in septic shock. Immunoreactive (i) Thromboxane (Tx) B2, the stable metabolite of TXA2' and i6-keto-PGF1α, the stable metabolite of prostacyclin, were measured by radioimmuonassay. plasma levels of iTXB2 rapidly increased from non-detectable (ND< 200 pg/ml) to 1,066 -/+ 194 pg/ml (N=14) 1 hour after feces injection. iTxB2 then increased to 1,695 -/+ 218 pg/ml (N=16) at 4 hours and remained unchanged through 6 hours. Plasma i6-keto-PGF1α increased from ND to 3,777 -/+ 414 pg/ml (N=16) at 1 hour. Four hours after feces, i6-keto-PGF1α levels rose to 6,945 -/+ 732 pg/ml (N=16) then continued to rise to 9,465 -/+ 792 pg/ml (N=7) at 6 hours. Either essential fatty acid deficiency (arachidonic acid depletion) or indomethacin pretreatment (cyclooxygenase inhibition) significantly decreased (P< 0.01) the elevations of plasma iTxB2 and i6-keto-PGF1α associated with fecal peritonitis. Thrombocytopenia occurred within 6 hours after injection of feces and was significantly improved (P< 0.05) by indomethacin. Elevated fibrin degradation products at 6 hours (18 -/+ 3 µg/ml) were significantly reduced in essential fatty acid deficient (7 -/+ 2 µg/ml; P< 0.05) and indomethacin treated (4 -/+ 0.7 µg/ml; P< 0.01) rats. Survival time (8.6 -/+ 0.2 hours) was significantly enhanced by essential fatty acid deficiency (10.2 -/+ 0.4 hrs; P< 0.01) or indomethacin pretreatment (13.3 -/+ 0.6 hrs; P< 0.01). These studies show that fecal peritonitis is associated with increased synthesis of thromboxane A2 and prostacyclin and suggest that these arachidonic acid metabolites may play a role in the pathophysiology of septic shock. To evaluate the pathogenic role of thromboxane (Tx) and prostacyclin (PGI2) in septic shock, the protective efficacy of the Tx synthetase inhibitor, 7(l-imidazolyl) heptanoic acid (7-IHA) and the cyclooxygenase inhibitor, ibuprofen, were assessed during fecal peritonitis in the rat. 7-IHA (60 mg/kg) administered ip 30 minutes prior to feces significantly reduced the plasma level of iTxB2 to ND (P< 0.01) at 1 hour and to 508 -/+ 56 pg/ml (P< 0.01) at 4 hours after injection of feces. In contrast, the levels of i6-keto-PGF1α, the stable metabolite of PGI2 were significantly elevated by 7-IHA pretreatment from septic control levels to 5,185 -/+ 467 pg/ml (P< 0.05) at 1 hour. Plasma i6-keto-PGF1α at 4 hours in 7-IHA treated rats (5,503 -/+ 665 pg/ml) was not different from untreated controls. Ibuprofen (5 mg/kg) administered ip 30 minutes prior to feces significantly decreased both iTxB2 and i6-keto-PGF1α plasma levels to 729 -/+ 99 pg/ml and 1,327 -/+ 251 pg/ml, respectively (P< 0.05) at 4 hours. Survival associated with fecal peritonitis was not altered by 7-IGA pretreatment, but was significantly improved (P< 0.05) in ibuprofen treated rates. Fibrin degradation products were also significantly decreased (P< 0.05) by 7-IHA pretreatment. These results suggest that TxA2 may contribute to the coagulopathies seen in septic shock and that PGI2 may be associated with terminal pathophysiologic events. The final phase of this project investigated the possible synergistic benefit between an antibiotic, gentamicin (GENT), and reduction of arachidonic acid metabolism by pre-administration of indomethacin (INDO) or essential fatty acid (EFA) deficiency. GENT significantly increased mean survival time to 23.8 -/+ 2.6 hours (N=16; P< 0.01). GENT + INDO or GENT + EFA deficiency further improved mean survival time and produced long term survivals (>48 hrs) of 35% (N=17) and 30% (N=7) respectively (P< 0.01 compared to GENT). GENT pretreatment did not significantly alter plasma iTxB2 levels, however, it selectively decreased i6-keto-PGF1α. For example, i6-keto-PGF1α decreased from 9,465 -/+ 792 pg/ml (N=7) to 2,096 -/+ 1174 pg/ml (N=5; P< 0.01) at 6 hours after induction of fecal peritonitis. GENT + INDO pretreatment significantly decreased both iTxB2 and i6-keto-PGF1α to ND (P< 0.01). Pretreatment with GENT alone did not reduce fibrin degradation products. These findings are consistent with the concept that TxA2 may play a role in consumptive coagulopathies and PGI2 may be associated with the terminal hypotension seen during septic shock. The effect of GENT on TxA2 and PGI2 production was investigated further. GENT had no observable effect on in vitro endotoxin stimulated production of these arachidonic acid metabolites by cultured rat peritoneal macrophages. GENT significantly reduced the plasma levels of iTxB2 and i6-keto-PGF1α during endotoxin induced shock in rats. These observations support a complex interaction of bacteria, endotoxin, host tissues, and gentamicin with the possible involvement of undescribed mediated factors.

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1980-1981), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1980-1981 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Dedication/Founders Day
• Reunions
• Flounders Day Follies
• Moving Day at 4190
• SAH Graduation
• People
• Faculty Notes
• News from the College
• News from the Hospital
• Pacemaker Evaluation Center
• Worth Mentioning
• Alumni News Briefs
• From the Alumni Office
• In Memoriam

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1980), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1980 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Commencement
• Honorary Degree Recipient
• Commencement Dinner
• Awards
• New Appointments
• Faculty Notes
• News from the Hospital
• News from the College
• Class of 1980 Internships
• Alumni News Briefs
• In Memoriam
• Gift Shop and Bookstore
• From the Alumni Office

The Analysis Of S-Adenosylmethionine And S-Adenosylhomocysteine In Normal And Neoplastic Cells, Kathryn Elizabeth Godburn

Chemistry & Biochemistry Theses & Dissertations

Altered patterns of methylation have been shown in both ribosomal and transfer RNA isolated from cancer cells. In contrast to the elevated activity of the methyltransferases responsible for this modification, hypomethylation appears as a general characteristic. The endogenous levels of S-adenosylmethionine and S-adenosylhomocysteine are important in relationship to their role as substrate and product of the transmethylation reaction. The levels of S-adenosylmethionine and S-adenosylhomocysteine were determined using phosphocellulose cation exchange or high pressure liquid chromatography. High voltage paper electrophoresis was used in a modified procedure to directly resolve (³⁵s) labeled S-adenosylmethionine and S-adenosylhomocysteine in small quantities of cell …

Changing Physician Ideologies On The Care Of The Dying: Themes And Possible Explanations, John Macdougall

The Journal of Sociology & Social Welfare

An analysis of changing physician ideologies regarding the care of elderly dying patients, as expressed in technical journals read by American physicians. Markedly more titles concerning terminal care are found in Index Medicus in 1968- 78 than in 1960-67. In one journal, physicians are only after 1964 urged to tell patients openly about their condition and after 1969, to improve cooperation within professional teams. Two explanations of these data are tentatively explored: 1) a Parsonian explanation, whereby medical ideologies reflect professional autonomy and the influence of internalized moral norms; 2) a Marxist explanation, whereby medical ideologies reflect physicians' transformation from …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1980), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1980 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• The President's Page
• 4190 Renovations Begin
• Meet the Board of Trustees
• New Appointments
• Laporte Physician Helps Restore Sight
• What is a D.O.?
• Faculty Notes
• News from the Hospital and Health Care Centers
• News from the College
• Nursing Alumnae
• Sports Wrap-up
• Come to the Fair! – The Philadelphia Fair
• Alumni News Briefs
• From the Alumni Office
• In Memoriam

1980 Beaumont Lecture: Restriction Enzymes As Tools For Genetic Research, Hamilton O. Smith

Henry Ford Hospital Medical Journal

No abstract provided.

Dissecting Aneurysm Of Aorta Complicating Coarctation Of The Aorta: Case Report And Brief Literature Review, Remigio Garcia, Julius M. Ohorodnik, Donald J. Magilligan Jr.

Henry Ford Hospital Medical Journal

The incidence of dissecting thoracic aorta aneurysm complicating coarctation of the aorta ranges from 1.7 to 23% in large series of coarctation of the aorta reported. In a review of 95 cases of dissection of the aorta, we found only one case with associated coarctation of the aorta. The presence of this anomaly, although rare, should be suspected and searched for in younger patients with dissection, in view of the surgical implications at the time of correction.

Vital Signs, January, 1980, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Isolation And Characterization Of A Vulvar Carcinoma In Tissue Culture: Studies Of The Tumor Biology And Tumor-Host Interaction, Melvin G. Dodson

Dissertations

No abstract provided.

"Sids: Current Areas Of Interest: Apnea, Monitors, And The High-Risk Infant", Alfred Steinschneider

Special Collections: Oregon Public Speakers

Session of Sudden Infant Death Syndrome: Informational Workshop, held October 20-21, 1979, at Portland State University.

The Synthesis And Evaluation Of The Potential Antineoplastic Activity Of The Semicarbazone And The Thiosemicarbazone Derivatives Of The Di-2-Pyridyl Ketone And The 1,8-Diazafluorenone Ring Systems, Adriene Y. Principe

Chemistry & Biochemistry Theses & Dissertations

A number of' a-(N)-heterocyclic thiosemicarbazones have been synthesized and evaluated for potential antineoplastic activity since Brockman and colleagues2 reported the antineoplastic activity of' 2-f'ormylpyridine thiosemicarbazone (1). The primary objective of' this research project has been the synthesis and characterization of' the semicarbazone and the thiosemicarbazone derivatives of' the di-2-pyridyl ketone, (9-a) and (9-b), and the 1,8-diazaf'luorenone, (10-a) and (10-b), ring systems, as well as the evaluation of' these compounds for both in vitro and in vivo antineoplastic activity against Ehrlich ascites tumor cells in mice. These studies have suggested that di-2-pyridyl ketone thiosemicarbazone (9-b) is as effective as 2-formylpyridine …