Digital Commons Network^™

Molecular And Cellular Biology Of Prostate Cancer, El-Nasir Lalani, Marc Elie Laniado, Paul David Abel

Department of Pathology and Laboratory Medicine

Prostate cancer is an enigmatic disease. Although prostatic-intraepithelial neoplasia appears as early as the third decade and as many as 80% of 80 year old men have epithelial cells in their prostate that fit the morphological criteria for cancer, only about 10% of men will ever have the clinical disease and less than 3% will die from it. There have been no significant proven interventions which have altered the natural history of the disease since hormone down regulation was introduced in the 1940s and new research has been poorly supported. There is however an urgent need to develop new criteria …

The Relationship Of Tooth Size And Arch Form To Arch Depth, Harold C. Avila

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine the relationship of arch form and tooth size to arch depth measurements of study models (Casts) and their respective lateral cephalometric radiographs (Radiographs) in a population of patients treated to an acceptable occlusion without extraction. One hundred and twenty casts were divided into three tooth size classes within each of four arch form categories. Results showed there was a statistically significant change in the arch depth measurement when tooth size was varied. There was no statistically significant change in the arch depth measurement when arch form was varied. The results showed greater …

Tuberculous Hepatic Artery Aneurysm: Multimodality Imaging, Y A. Husen, M U. Islam, I H. Rizvi

Department of Radiology

No abstract provided.

Characterization Of Angiotensin Ii Receptor Subtypes In The Brain, David L. Saylor

Electronic Theses and Dissertations

The present studies explore binding, distribution, and function of angiotensin II (AII) receptors (AT$\sb1$ and AT$\sb2)$ in the brain. The discovery that sulfhydryl reducing agents masked some but not all AII receptors in the brain prompts an evaluation of commonly used binding assay buffer constituents. EDTA enhances binding (40%) at both AT$\sb1$ and AT$\sb2$ nuclei, while bacitracin did not alter binding at either receptor subtype. Phenanthroline and BSA differentially altered binding at AT1 (220% of control) and AT$\sb2$ (118% of control) receptors. The results indicate that phenanthroline and BSA would be poor buffer constituents for studies comparing binding at AT$\sb1$ …

Hallucinations, Peter J. Whitehouse, Marian B. Patterson, Milton E. Strauss, David S. Geldmacher, James L. Mack, Grover C. Gilmore, Elizabeth Koss

Faculty Scholarship

No abstract provided.

Enhancing Compliance With Allergic Rhinitis Therapy, Beth Wofford, Deborah S. Zeitlin

Scholarship and Professional Work – COPHS

Allergic rhinitis is one of the most common chronic conditions in the US, surpassing even heart disease. Over $1 billion is spent annually for over-the-counter (OTC) and prescription medications. In addition, allergic rhinitis causes an estimated annual loss of $639 million related to lost work days and diminished work performance.

If not effectively treated, allergic rhinitis may lead to potential complications such as otitis media, sinusitis, facial and dental abnormalities, hearing loss, poor speech development, and recurrent upper respiratory tract infections. Ineffective treatment often the result of intentional or unintentional noncompliance and inadequate patient education. Therefore, it is imperative that …

The Effect Of The Hapad Longitudinal Metatarsal Arch Pad On Ground Reaction Forces And Rear Foot Angle, William F. Rocker

Masters Theses

The effectiveness of the Hapad Longitudinal Metatarsal Arch Pad (HLMAP) to correct for pronation was investigated using 30 female volunteer student subjects. The investigation consisted of measuring ground reaction forces measured by a force plate and rear foot angle (RFA) measured by video digitization. The repeated measures design consisted of l grouping variable with 3 levels, supinators, mildpronators, and over pronators, and 2 research variables, 10 trials, and pad/no-pad. The results indicated (a) no significant difference for medial or lateral force, propulsive force, vertic al thrust, negative torque among groups, or between pad/no-pad; (b) a significant difference was found for …

Vital Signs, Spring 1997, Boonshoft School Of Medicine

Vital Signs

A twenty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

The Influence Of Low Dietary Fat Intake On Incidence And Severity Of Migraine Headache, Zuzana Bic

Loma Linda University Electronic Theses, Dissertations & Projects

Migraine headaches are a common and debilitating syndrome causing untold suffering and loss of productivity. A review of the literature indicates that there are two primary factors involved in triggering these headaches: high levels of blood lipids and high levels of free fatty acids. Under these conditions platelet aggregability is increased, which is associated with decreases in serotonin and heightened prostaglandins levels. These conditions may produce vasodilation, the most immediate precursor to migraine headache. A high fat diet is one factor that may directly affect this process. This study was undertaken to evaluate the impact of dietary fat intake on …

Immunophenotypic Analysis Of Non-Hodgkin's Lymphoma, Suhail Muzaffar, Shahid Pervez, Farrukh Aijaz, Syed Abdul Aziz, Sheema H. Hasan

Department of Pathology and Laboratory Medicine

One hundred and three cases of Non-Hodgkin’s lymphoma were evaluated immunohistochemically using a panel of monoclonal antibodies which includes leucocyte common antigen (LCA), CD45R (Pan-B marker), L-26 (CD 20-Pan-B marker) and UCHL-1 (Pan-T marker). Of the total 63 cases (61.17%) showed a B-cell phenotype while 40(38.83%) were of T-cell origin. Most B-cell neoplasms belonged to intermediate (79.36%) or high grade (15.87%) according to the international Working Formulation (WF). Most T- cell lymphomas were of either intermediate (52.5%) or high grade (32.5%) neoplasms. Some T-cell neoplasms presented as specific clinicopathological entities like lymphomatoid granulomatosis (2 cases), mycosis fungoides (1 case) and …

Classification And Immunophenotyping Of Acute Leukemias: A Prospective Study., Shahid Pervez, M. Khurshid

Department of Pathology and Laboratory Medicine

Over a period of 3-1/2 years, 86 cases of acute leukemia were analyzed by immunohistochemical (IHC) means on ficoll separated cytospin preparations of peripheral blood and/or bone marrow samples. Antibodies included in the panel were specific against Tdt, HLA-DR, CD19/CD2O/CD22, CALLA (CD1O), CD2, CD11C as well as against Ig heavy chains. Of 86 cases analyzed, 48 cases were of ALL, (25 of common pre-B ALL, 15 of pre-B/NULL and 8 of T ALL phenotype), twenty-four (24) out of 86 cases were of non­lymphoblastic (AML/AMML) type. In six cases, there was suggestion of a mixed lineage, while in 8 cases there …

Ureteroscopic Lithotripsy., Demetrius H. Bagley

Department of Urology Faculty Papers

There is a wide array of endoscopic lithotriptors presently available. Each of these has its own advantages and disadvantages. No single lithotriptor is suitable for all applications and none can meet the goal of fragmenting all calculi while remaining harmless to tissue.

Neuroprotective Action Of Cycloheximide Involves Induction Of Bcl-2 And Antioxidant Pathways, Katsutoshi Furukawa, Steven Estus, Weiming Fu, Robert J. Mark, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Publications

The ability of the protein synthesis inhibitor cycloheximide (CHX) to prevent neuronal death in different paradigms has been interpreted to indicate that the cell death process requires synthesis of “killer” proteins. On the other hand, data indicate that neurotrophic factors protect neurons in the same death paradigms by inducing expression of neuroprotective gene products. We now provide evidence that in embryonic rat hippocampal cell cultures, CHX protects neurons against oxidative insults by a mechanism involving induction of neuroprotective gene products including the antiapoptotic gene bcl-2 and antioxidant enzymes. Neuronal survival after exposure to glutamate, FeSO₄, and amyloid β-peptide …

Foundation News: March 1997, University Of Health Sciences Foundation

Foundation News (1997)

Contents: John Floersh Physicians' Hall of Sponsors Established -- UHS Foundation Heritage Society -- Class of 1967 Reunion Gift Goal Established -- Foundation Board Expanded -- Foundation Fund Grants Made -- Houston Osteopathic Hospital Foundation Remembers Dr. William A. Thomas.

Special Maneuver For Removal Of An Impacted Bronchial Foreign Body At Thoracotomy, Saima H. Khan, Asad Mian, Qaisar M. Khan, Naeem-Uz-Zafar Khan

Department of Emergency Medicine

Tracheobronchial foreign body aspiration is a common, but often unobserved event in children. A delay in diagnosis can lead to difficulty in removal of the aspirated object. The present case report highlights a special intraoperative maneuver at thoracotomy that was adopted to remove an impacted foreign body that could not be removed at bronchoscopy.

Percutaneous Removal Of Biliary Stone From Anomalous Right Hepatic Duct, T Ul Haq, M Y. Sheikh, C K. Jadun, M N. Ahmad, Y H. Husen

Department of Radiology

No abstract provided.

Profile And Risk Factors For Congenital Heart Disease, I Hassan, A A. Haleem, Z A. Bhutta

Department of Paediatrics and Child Health

Congenital heart disease is an important cause of infant mortality and disability. The frequency, spectrum and contributory risk factors for significant cardiovascular malformations among live-births was retrospectively evaluated at the Aga Khan University Hospital. Of a total of 8331 live births between July, 1987 and December, 1992 34 babies were diagnosed to have congenital heart disease in the neonatal period giving a prevalence of 4 per 1000 live births. Ventricular septal defects was the most common (n = 10, 29%) abnormality. Eight cases had associated chromosomal abnormality, the most common being Trisomy 21. Maternal abortions, still-births, consanguinity and diabetes mellitus …

New England Osteopathic Association: New England Cme Blueprint Committee Minutes 1997-2-10, Stephen Shannon D.O.

William Kirmes, D.O. Collection

Meeting Minutes from the New England CME Blueprint Committee convened to develop a blueprint for future CME programs in New England.

Loss Of Dcc Expression And Glioma Progression., M Reyes-Mugica, K Rieger-Christ, H Ohgaki, B C Ekstrand, M Helie, G Kleinman, Alan M. Yahanda Md, Facs, E R Fearon, P Kleihues, M A Reale

PCI Publications and Projects

The deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene on chromosome 18q21, encodes a neural cell adhesion molecule family protein that is most highly expressed in the nervous system. To address the hypothesis that DCC may play a role in glioma development and/or progression, we examined DCC expression by immunohistochemistry in 57 resected human astrocytic tumors. Overall, low-grade astrocytomas were predominantly DCC positive (15 of 16, or 94%), whereas high-grade tumors significantly less often expressed the DCC protein (27 of 41, or 66%; P = 0.03). We were able to directly assess the relationship between DCC expression …

The Role Of Zinc In Health And Disease: Relevance To Child Health In Developing Countries, Z A. Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Standing Up To Osteoporosis, Robert W. Downs

Case Studies from Age in Action

Educational Objectives

1. To provide basic information about osteoporosis, including risk factors, diagnostic testing, treatment, and prevention.

2. To get you to help us spread the word that osteoporosis can be diagnosed and treated, and that there are things you can do to decrease your future risk for developing osteoporosis.

Health Professions Division Catalog Academic Year 1997-1998, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Ambulatory Arthroscopic Knee Surgery Results Of Partial Meniscectomy, Muhammad Umar

Section of Orthopaedic Surgery

In an open prospective study the results of arthroscopic partial meniscectomy were reviewed in 188 knees. Group I comprised of 139 (65%) knees with pure meniscus lesions without any ligament laxity, the remaining 49 (35%) knees in group II had anterior cruciate ligament (ACL) deficiency in addition to meniscus lesions. In group I, 93% had excellent to good and 7% had fair results by criteria of Tapper and Hoover. In group II, 75% had excellent to good and 25% had fair results. Arthroscopic knee surgery was a good method of identifying patients in group II who required anterior cruciate reconstruction. …

A Characterization Of Early B-Lymphopoiesis: The Differentiation Of Lymphohemopoietic And Early Committed B-Lymphoid Progenitors, Timothy C. Ball

MUSC Theses and Dissertations

Studies of B-lymphopoiesis have long been hindered by the lack of assays capable of supporting the differentiation and identification of lymphohemopoietic and early committed B-lymphoid progenitors. The clonal identification of cell-cycle dormant lymphohemopoietic progenitors from mice treated with 5 flurouracil (5-FU) became possible with the development of the two-step assay for lymphohemopoietic progenitors. Studies presented in this dissertation are centered around elucidation of the processes of differentiation of lymphohemopoietic progenitors in an attempt to determine the sequence of events occurring in divergence of the B-lymphoid and myeloid lineages. To address this question a single-step assay capable of supporting the differentiation …

The Role Of Reactive Oxygen Species In The Induction Of Interleukin-8 (Il-8) By Rhinovirus, Matthew Biagioli

MUSC Theses and Dissertations

There is a direct correlation between the severity of common cold symptoms and the concentration of IL-8 in nasal secretions from volunteers with experimental human rhinovirus (hRV) colds. Although these and other data are consistent with the hypothesis that IL-8 is a mediator of common cold symptoms, the mechanism by which IL-8 is elaborated in response to hRV challenge is not understood. This study examined the role of oxidative stress and NF-κB activation in hRV induced IL-8 elaboration. All studies were done in either a transformed respiratory epithelial cell line (Beas-2b) or human lung fibroblasts (MRC-5). Induction of oxidative stress …

Late Onset Oesophageal Perforation Due To Gunshot Injury Of Chest: Successful Non-Operative Management In A Young Child, Asad Mian, Saima H. Khan, Naeem-Uz-Zafar Khan

Department of Emergency Medicine

Penetrating firearm injuries of the chest have become commonplace in children living in violent urban areas. Esophageal perforation may present as a late manifestation of peadiatric thoracic trauma due to gunshot injury. Opinion varies as to the surgical or nonsurgical management of such a patient. The authors report a case of a 12-year-old girl who presented with a similar dilemma and her successful conservative management, that they opted for; is discussed.

Ms211: Radefx Tm Registration 02261997, Armin Weinberg

Works on Radiation Effects: 1990-2020

Armin Weinberg, PhD Papers and its finding aid.

A Randomized Clinical Trial To Compare Selective Posterior Rhizotomy Plus Physiotherapy With Physiotherapy Alone In Children With Spastic Diplegic Cerebral Palsy, Paul Steinbok, Ann M. Reiner, Richard Beauchamp, Robert Armstrong, Douglas Cochrane

Paediatrics and Child Health, East Africa

A randomized controlled single-blind trial was performed to compare lumbo-sacral selective posterior rhizotomy (SPR) followed by intensive physiotherapy, with intensive physiotherapy alone in improving motor function in children with spastic diplegic cerebral palsy. Fifteen patients were randomly assigned to each treatment modality. Patients in the SPR group had rhizotomy within 1 month, followed by intensive outpatient physiotherapy for 9 months. Patients assigned to physiotherapy alone had identical intensive physiotherapy. There was a statistically significant and clinically important difference in improvement in motor function in favor of the SPR group, with a mean increase in total Gross Motor Function Measure (GMFM) …

Social And Cultural Factors Affecting Rates Of Regular Retreatment Of Mosquito Nets With Insecticide In Bagamoyo District, Tanzania, P.J. Winch, A.M. Makemba, V.R. Makame, M.S. Mfaume, M.C. Lynch, Zul Premji, J.N. Minjas, C.J. Shiff

Pathology, East Africa

Insecticide-treated mosquito nets have an impact on mortality and morbidity in young children under controlled conditions. When integrated into larger control programs, there is the danger that rates of regular retreatment of the nets with insecticide will drop, greatly limiting their effectiveness as a public health intervention. In Bagamoyo District, Tanzania, rates of retreatment dropped significantly when payment for the insecticide was introduced. A series of neighbourhood (hamlet) meetings were held in all study villages to discuss people's concerns about the insecticide and ways to increase rates of retreatment. Although changes were made in the procedure for retreatment, rates of …

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1997), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1996 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• The Faces of Founders Day 1997
• PCOM Welcomes Four Alumni Board Members
• PCOM Salutes Army “Top Doc" Gen. Ronald Blanck
• College Board Profile
• Alumni Board Profile
• Campus Update
• Capital Campaign Developments
• New Executive Vice President: Samuel H. Steinberg
• PCOM Gears Up for its 1999 Centennial
• Class Acts
• In Memoriam
• PCOM’s Website
• Just Published
• PCOM in the Media
• Coming Events