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Oncolog, Volume 47, Number 06, June 2002, Kate O'Suilleabhain, Dawn Chalaire, Shellie M. Scott Bs

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Drug Development Program Paves the Way for FDA Approval of New Agents
• Pediatric New Agents Working Group Advances the Study of Novel Treatments in Young Patients
• DiaLog: Patients and Physicians: Partners in Health Care, by Shellie M. Scott, BS, Physician Assistant, Department of Urology
• House Call: Taking a More Active Role in Your Own Health Care
• As Population of Cancer Survivors Grows, Studies of Long-Term Health Effects Become More Critical, Researchers Say

Transportation: A Crucial Issue For Adult Day Care In Vermont, Francis G. Caro, Regula H. Robnett, Jennifer Higgins

Gerontology Institute Publications

Transportation arrangements are an integral but fragile element in the effectiveness of adult day care services in Vermont and nationwide. Almost by definition, adult day center participants generally cannot drive due to cognitive and/or physical limitations. Since adult day care services are congregate in nature and serve community-residing elders, this long-term care option is feasible only when there are arrangements to transport elders to and from service centers. Transportation is therefore a major issue for adult day care services.

The aim of this report is to call attention to transportation issues in adult day care services in Vermont. The report …

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 2002), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 2002 Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• It's a Family Practice Affair
• Helping People Age Successfully
• Why Don't Patients Comply?
• Class Notes
• In Memoriam
• My Turn
• Andrew Taylor Still Legacy Society
• PCOM Events

Takayasu's Arteritis Presenting As Ischemic Stroke--Case Report, B A. Khealani, S M. Baig

Section of Neurology

Takayasu’s Arteritis is a chronic, idiopathic, inflammatory disease that primarily affects large blood vessels such as aorta and its branches.1 Neurological symptoms occur in about 50% of cases but stroke occurs in about 10% of patients with Takayasu’s Arteritis2 . We report two such cases and emphasize the need for thorough evaluation of young patients with stroke to establish the underlying etiology.

Cancer Patterns In Karachi Division (1998-1999), Y. Bhurgri, S. Naseeruddin, S. A. H. Zaidi, A. Bhurgri, Z. A. Zaidi, S. H. Hasan, A. Usman, N. Faridi, K. Z. Hashmi, H. Ahsan, J. Malik, M. Khurshid, Shahid Pervez, Naila Kayani, S. M. H. Zaidi, I. Bashir, Z. Isani, F. Sethna, S. M. Aiam

Department of Pathology and Laboratory Medicine

Objective: A minimal cancer incidence data for Karachi, the largest city of Pakistan, is being presented here, for the years 1998-1999. The city has a population of 9,802,134; males 5,261,712 (52.6%) and females 4,540,422 (47.4%); census 19981.

Methodology: A predominantly mixed (passive and active) registration system has evolved in Karachi, the data sources being the hospitals within the Karachi Division. The reported/retrieved cancer data sets at the Karachi Cancer Registry are checked, coded, computerised in an analytical format and analysed.

Results: The incident cancer cases registered in Karachi, during the 2-year period, 1st January 1998 to 31st December 1999 were …

Current Practice Regarding The Use Of Fatty Livers: A Trans-Atlantic Survey., Charles J. Imber, Shawn D. St Peter, Inigo Lopez, Lynden Guiver, Peter J. Friend

Manuscripts, Articles, Book Chapters and Other Papers

A strong association exists between the presence of steatosis in a donor liver for transplantation and the development of primary nonfunction in the recipient. Despite this, appraisal of the donor remains one of the least scientific aspects of the transplantation process, and many centers base their practice on subjective opinion, rather than objective data. We conducted this survey to illuminate controversial issues and highlight the variation of opinion and practice policies both between and within the United Kingdom and the United States. A simple, anonymous, one-page, 10-question survey with tick-box answers was sent to every practicing liver transplant surgeon in …

Medical Education Digest, Vol. 4 No. 3 (May 15, 2002), Nova Southeastern University

Medical Education Digest

No abstract provided.

Update - May 2002, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- The Compleat Physician
-- Informed Consent Documentation for Total Artificial Hearth Technology
-- Ralph J. and Carolyn Thompson Endowment established in 2001

Oncolog, Volume 47, Number 05, May 2002, Kerry L. Wright, Ann Sutton, Carmelita Escalante Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Tobacco Research and Treatment Progra Studies Include Ways to Prevent and Treat Nicotine Dependence in Special Populations
• Emergency Center Provides Specialized Care for M. D. Anderson Patients Experiencing Oncologic Emergencies
• DiaLog: M. D. Anderson's Emergency Center, by Carmelita Escalante, MD, Associate Professor and Ad Interim Chair, Department of General Internal Medicine, Ambulatory Treatment, and Emergency Care
• House Call: Depression and Cancer
• Smoking Cessation Studies Blend Computer Technology with Behavioral Therapy

Clinical, Pathological And Molecular Factors Predicting Axillary Node Involvement In Primary Breast Cancer In Pakistani Women, T. Siddiqui, A. Salam, S. Khan, N. Kayani, Shahid Pervez

Department of Pathology and Laboratory Medicine

Background:

Axillary lymph node involvement in primary breast cancer is one of its most important prognostic features. Thus any factors that may predict axillary lymph node involvement in this setting could be potentially helpful in treatment planning and other interventions.

Objective:

The objective of this study was to evaluate clinical, pathological and immuno-histochemical markers in univariate and multivariate analysis, which may be helpful predictors of axillary lymph node involvement in breast cancer.

Method:

A retrospective analysis of 555 cases. Of these 58% had axillary nodal positivity and 42% were negative.

Conclusion:

Factors of no significance included patient’s age, height, weight, …

Extended Preservation Of Non-Heart-Beating Donor Livers With Normothermic Machine Perfusion., Shawn D. St Peter, C J. Imber, I Lopez, D Hughes, P J. Friend

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Non-heart-beating donor (NHBD) livers represent an important organ pool, but are seldom utilized clinically and require rapid retrieval and implantation. Experimental work with oxygenated perfusion during preservation has shown promising results by recovering function in these livers. This study compared sanguinous perfusion with cold storage for extended preservation of the NHBD liver in a porcine model.

METHODS: Porcine livers were subjected to 60 min of in vivo total warm ischaemia before flushing, after which they were preserved by one of two methods: group 1 (n = 4), University of Wisconsin (UW) solution by standard cold storage for 24 h; …

Hepatic Steatosis And Its Relationship To Transplantation., Charles J. Imber, Shawn D. St Peter, Ashok Handa, Peter J. Friend

Manuscripts, Articles, Book Chapters and Other Papers

Fatty infiltration of the liver is common in the brain-dead donor population and has a strong correlation with primary nonfunction after cold preservation, a condition that is catastrophic to liver transplant recipients. This literature review examines factors associated with the development, diagnosis, quantification, and clinical management of this difficult condition.

Lake Mead Hospital Conversion To Complete Delivery System, Roger W. Noorda

UNLV Theses, Dissertations, Professional Papers, and Capstones

The objective of this case study is to determine the cost difference between using a conventional type of inventory system in the operating room versus using a pack system in the operating room. In this study three different ways of delivering disposables for a laminectomy procedure were considered: 1) multiple distributors of disposables, 2) single distributor of disposables, and 3) the pack system (CDS by Medline). The first comparison was of multiple distributors vs. a single distributor with a cost difference of $90.08 per procedure and $18,916.80 annually, multiple distributor costing less. The second comparison was between Medline as a …

Com Outlook Summer 2004, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

The Reliability Of Emg Normalization Procedures For Three Muscles Invol Ved In Knee Extension, Gerrik J. Schepel

Masters Theses

This retrospective study analyzed the three muscles involved in knee extension: vastus medialis, rectus femoris, and vastus lateralis. lt was conducted to determine the reliability of normalization procedures when evaluating the EMG response detected from a muscle. During a maximal voluntary isometric contraction {MVIC), the EMG response of the muscle was recorded and the iEMG moment per unit area was determined. The iEMG response ofthe quadriceps muscles during dynamic exercise was normalized using the MVIC. Subjects (N = 44) performed two consecutive MVICs with a 2-min rest between trials at 110°, 90°, 70°, 50°, and 30° of knee flexion, …

Role Of Disulphide Bond Formation In Folding, Secretion, And Assembly Of Human Chorionic Gonadotropin Subunits., Elliott Bedows, Ryan J. Darling, Jason A. Wilken, Simon Sherman

Journal Articles: Eppley Institute

Ability of a glycoprotein hormone to fold and assemble correctly is an essential requirement for the attainment of its biological activity . Cells have a quality control system to assure that when proteins of the endoplasmic reticulum mi sfold or fail to assemble correctly they do not exit the cell. But human chorionic gonadotropin (hCG) is an exception to this rule as is illustrated by the following observations. First, both hCG subunits are secreted efficiently as unassembled monomers. Second, some mis(un)folded forms of hCG-β can be efficiently secreted from cells that do not facilitate the secretion of other misfolded proteins. …

Effectiveness Of Current Therapy Of Bacterial Vaginosis, Petya M Andreeva, Hatim A. Omar

Pediatrics Faculty Publications

The study was conducted in order to evaluate effectiveness of the treatment of bacterial vaginosis (BV) with different therapeutic regimes according to recommendations of the World Health Organization (WHO). During a one-year period (February 2000-February 2001) the Sexually Transmitted Diseases (STD) Center was visited by 482 women aged 14-51. The diagnosis of BV was established by standard methods: Amsel's clinical criteria and Gram stain of vaginal discharge. The first-line treatment was oral Metronidazole 2 g single dose. Second line was Metronidazole 500 mg twice daily orally for 7 days or oral Clindamycin 300 mg twice daily for seven days. BV …

View Box Case--4 Left Sided Tuberculous Autonephrectomy, I Masroor, R Hashmi

Department of Radiology

No abstract provided.

Oncolog, Volume 47, Number 04, April 2002, Beth Notzon, Karen Stuyck, Felipe Samaniego Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Researchers Focus on Bioimmunotherap for Treatment of Non-Hodgkin's Lymphomas
• Protocols: Non-Hodgkin's Lymphoma Studies
• House Call: The First Cancer Prevention Vaccine
• DiaLog: The Viral Origins of Lymphomas, by Felipe Samaniego, MD, Assistant Professor, Department of Lymphoma and Myeloma
• Research Consortium Recruiting Volunteers to Study the Role of Genetics in Cancer Development and Patient Care

Improved Continuation Rate Of Depot-Medroxyprogesterone Acetate In Adolescent Mothers, Hatim A. Omar, Amy Fowler, Sandy D'Angelo

Pediatrics Faculty Publications

Poor compliance and high discontinuation rates of Depot-Medroxyprogesterone Acetate (DMPA) and other contraceptive methods are major factors in the continuing problem of adolescent pregnancy. In this study we attempted to determine if providing comprehensive health care for teen mothers and their babies would improve continuation rates of DMPA. Patients who started DMPA between 1/1/96 and 1/1/99 were included. Teen mothers and their babies received all their health care in this clinic, supported by State funding. Key elements regarding DMPA in this clinic were continuity of care, phone and mail reminders of appointments, free DMPA for patients without insurance, counseling at …

Mexican-Descent Latinas’ Compliance With Cervical Cancer Screening Guidelines, Evelinn A. Borrayo, Awilda Reyes

University Libraries Faculty Publications

No abstract provided.

Prostate Specific Membrane Antigen (Psma): Immunoassay Development And Characterization Of Transcriptional Regulation, Zhen Xiao

Theses and Dissertations in Biomedical Sciences

Prostate cancer (PCA) is the most common cancer and the second leading cause of death among American men. The high mortality is greatly attributed to the lack of early detection tools and effective treatment for metastasis and relapses. Biomarkers that can discriminate benign from malignant tumor and signal the development of androgen independent and metastatic tumor are needed. A biomarker designated prostate specific membrane antigen (PSMA) has the potential to fulfill this need. The objective of this study is to develop a clinically useful immunoassay for quantitation of serum PSMA and to study the molecular mechanism underlying the upregulation of …

Medical Education Digest, Vol. 4 No. 2 (March 15, 2002), Nova Southeastern University

Medical Education Digest

No abstract provided.

Siva-1 Binds To And Inhibits Bcl-Xl-Mediated Protection Against Uv Radiation-Induced Apoptosis, Li Xue, Fei Chu, Yuan Cheng, Xiangjie Sun, Alip Borthakur, Manjunath Ramarao, Pramod Pandey, Mei Wu, Stuart F. Schlossman, Kanteti V. S. Prasad

Clinical & Translational Sciences

We previously cloned Siva-1 by using the cytoplasmic tail of CD27, a member of the tumor necrosis factor receptor family, as the bait in the yeast two-hybrid system. The Siva gene is organized into four exons that code for the predominant full-length Siva-1 transcript, whereas its alternate splice form, Siva-2, lacks exon 2 coding sequence. Various groups have demonstrated a role for Siva-1 in several apoptotic pathways. Interestingly, the proapoptotic properties of Siva-1 are lacking in Siva-2. The fact that Siva-1 is partly localized to mitochondria despite the absence of any mitochondrial targeting signal, it harbors a 20-aa-long putative amphipathic …

Transitions Along The Continuum Of Care: Elderly And Disabled Persons In New York, Lisa Sprague, Nora Super

National Health Policy Forum

This site visit examined transitions along the continuum of care for elderly and disabled persons in New York. The state offers its residents an extensive array of services, including nursing homes, home health care, personal care, and community-based services. New York spends more than any other state on its Medicaid program, which is reflected in a comprehensive benefit package, full-cost reimbursement of hospitals, high nursing home rates, and extensive coverage of personal care services. Site visitors were briefed on the history and development of long-term care in the state as well as the various care settings available. Panels discussed transitions …

Predictors Of Mortality In Brain Abscess, H U. Qureshi, A A. Habib, A A. Siddiqui, T Mozaffar, A R. Sarwari

Section of Neurosurgery

Objective: Brain abscess carries significant morbidity and mortality. Our objective was to elucidate the clinical presentation of brain abscess and to assess predictors of mortality in these patients.
Methods: All patients with a brain abscess presenting to the Aga Khan University Hospital, a tertiary care referral center in Karachi, Pakistan, were studied retrospectively. Statistical analysis involved univariate analysis and a logistic regression model.
Results: Among the 66 patients analyzed, a distant metastatic focus of infection was the most commonly identified predisposing factor (29%). Otogenic infection was the commonest contiguous source and sinusitis was noticeably absent. Multiple abscesses were frequent (35%). …

Prevention Of Radiation-Induced Skin Reactions In Breast Cancer External Irradiation, Cathy Ammerman

Masters Theses & Specialist Projects

Radiation dermatitis is a common side effect of external beam radiation therapy. The purpose of this study was to evaluate the effectiveness of applying an aloe vera based skin gel to the target area skin in preventing the development of radiation dermatitis to postlumpectomy/ mastectomy patients receiving external beam radiation therapy in an ambulatory radiation-oncology clinic in the southeastern region of the United States. In this descriptive correlational study, a convenience sample of willing participants (n=18) was followed from initial treatment through the one-month follow-up examination to assess the intensity of their skin reaction. Five research questions were examined pertaining …

View Box Case--3 Hepatic Hemangioma, I Masroor, R Hashmi

Department of Radiology

No abstract provided.

Oncolog, Volume 47, Number 03, March 2002, Vickie J. Williams, Michael Worley, Noelle Heinze, Richard J. Babaian Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Largest-Ever Cancer Prevention Study to Examine the Effects of Selenium and Vitamin E on Prostate Cancer Occurrence
• Protocols: Prostate Cancer Clinical Trials
• House Call: Understanding Metastasis
• DiaLog: The Prostate--Specific Antigen Test: Reliability and Recommended Use, by Richard J. Babaian, MD, Professor, Department of Urology
• Trouble Spots: Early Detection Is Key to the Successful Treatment of Melanoma

Vital Signs, Spring 2002, Boonshoft School Of Medicine

Vital Signs

A twenty-eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes feature articles, an alumni profile, class notes, and more.