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The Analysis Of S-Adenosylmethionine And S-Adenosylhomocysteine In Normal And Neoplastic Cells, Kathryn Elizabeth Godburn

Chemistry & Biochemistry Theses & Dissertations

Altered patterns of methylation have been shown in both ribosomal and transfer RNA isolated from cancer cells. In contrast to the elevated activity of the methyltransferases responsible for this modification, hypomethylation appears as a general characteristic. The endogenous levels of S-adenosylmethionine and S-adenosylhomocysteine are important in relationship to their role as substrate and product of the transmethylation reaction. The levels of S-adenosylmethionine and S-adenosylhomocysteine were determined using phosphocellulose cation exchange or high pressure liquid chromatography. High voltage paper electrophoresis was used in a modified procedure to directly resolve (³⁵s) labeled S-adenosylmethionine and S-adenosylhomocysteine in small quantities of cell …

Recurrent Klebsiella Meningitis Following Trans-Sphenoidal Hypophysectomy For Nelson's Syndrome: Chloramphenicol Resistance During Relapse, Tom Madhavan, Daria Kiani, Louis Saravolatz, Keith Burch, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

Three episodes of meningitis due to Klebsiella pneumoniae occurred in a young man following cerebral surgery. The patient had the features of Nelson's syndrome, and a chromophobe adenoma was removed by trans-sphenoidal resection. Intravenous chloramphenicol was effective in producing a temporary clinical response during the first episode of meningitis, but the organism became resistant to chloramphenicol during the second episode. Combined parenteral and intralumbar administration of gentamicin resulted in temporary improvement only. Subsequently, the subcutaneous cerebrospinal fluid (CSF) reservoir of Ommaya provided a safe, convenient way to administer prolonged intraventricular therapy which, combined with a definitive procedure to correct the …

Richmond Smith As A Clinical Investigator: His Work On Adult Periosteal Bone Expansion And Nutritional And Endocrine Aspects Of Osteoporosis In Light Of Current Concepts, A. M. Parfitt

Henry Ford Hospital Medical Journal

This paper discusses Richmond Smith's contributions to the field of metabolic bone disease from 1949 to 1969 in light of current concepts. He was the first to demonstrate continuing periosteal bone expansion in adults, a phenomenon of great biologic interest which is best explained if adult bone remodelling is qualitatively similar on all surfaces. He was the first to show that persons with less bone than normal have an increased risk of subsequent fracture, and so are more likely to benefit from preventive treatment. He found that blood vitamin D levels were lower in osteoporotic subjects than in controls, but …

The Acute Effect Of Piretanide Upon Serum And Urinary Calcium In Normal Subjects, Cristina Casco, Patricia Fainstein Day, Carlos Mautalen

Henry Ford Hospital Medical Journal

We gave piretanide, a new diuretic, at two dose levels to six normal subjects. Sodium excretion increased six to eightfold in the first two hours, and diuresis was completed within four hours. There was a simultaneous increase in the excretion of calcium which exceeded the amount present In the mobilized extracellular fluid. The resulting deficit of calcium produced a small but significant fall in serum calcium corrected for protein. After diuresis ended, calcium was retained but not sodium, when compared to basal values on the previous day. The fall in urinary calcium and the failure to correct the sodium deficit …

Cushing's Disease, A Pituitary Disorder: A Hypothesis, M. Saeed Zafar, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

At present, Cushing's disease Is believed to be due to Inappropriate secretion of adrenocorticotropic hormone (ACTH). Associated abnormalities such as disturbed sleep pattern, growth hormone secretion, depressed thyroid hormone levels, and gonadal function are considered by some as manifestations of a generalized central nervous system disturbance, with abnormal ACTH secretion as one of the components. Recognition of microadenomata in Increasing numbers of patients with Cushing's disease, the reversal of hypothalamic abnormalities after adenomectomy, and correction of hypercortisolemia all suggest that the central nervous system disturbances result from Cortisol excess. We hypothesize that the basic abnormality in Cushing's disease is the …

Dietary And Hormonal Factors In Bone Loss, Richmond W. Smith Jr.

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Lipoprotein Lipase Inhibitor Removal During Ultrafiltration Of Renal Failure Patients, Alisa Minear

Loma Linda University Electronic Theses, Dissertations & Projects

Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C¹⁴-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as …

Vital Signs, May, 1980, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Newsletter, Volume 25, Number 03, May - June 1980, John M. Daly Md, Edward M. Copeland Md, Stanley J. Dudrick Md, R. Bruce Bracken Md

Newsletter: A Report to Physicians of Texas Archives

• ACS Representative Explains New Cancer-Related Health Checkup Recommendations
• Intravenous Hyperalimentation Improves Immunocompetence in Cancer Patients, John M. Daly, MD, Edward M. Copeland, MD, and Stanley J. Dudrick, MD
• Computer Center Aids Researchers, Students
• Noteworthy
• Semen “Banking” No Solution for Many Patients, R. Bruce Bracken, MD, and Keith D. Smith, MD
• E.J. Freireich Named President of ASCO
• Brazilian Doctors Observer MDAH Treatment

A Study Of The Physiological And Mental Effects Of Various Shift Patterns On Registered Nurses, Carolyn Taylor Smith

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of shift work on circadian I an rhythms has become a subject of great Interest to many industries, hospitals, and sleep researchers. More and more recognition is being given to the results of these studies, especially the possible adverse effects on those working the night shift or a shift they are unable to adapt to adequately. Only a few of these studies, however, have been conducted on registered nurses, a major group involved with shift work.

The purpose of the present study was to investigate the effects on nurses working the a.m. shift (7 a.m. to 3:30 p.m.), …

Changing Physician Ideologies On The Care Of The Dying: Themes And Possible Explanations, John Macdougall

The Journal of Sociology & Social Welfare

An analysis of changing physician ideologies regarding the care of elderly dying patients, as expressed in technical journals read by American physicians. Markedly more titles concerning terminal care are found in Index Medicus in 1968- 78 than in 1960-67. In one journal, physicians are only after 1964 urged to tell patients openly about their condition and after 1969, to improve cooperation within professional teams. Two explanations of these data are tentatively explored: 1) a Parsonian explanation, whereby medical ideologies reflect professional autonomy and the influence of internalized moral norms; 2) a Marxist explanation, whereby medical ideologies reflect physicians' transformation from …

Persistent Obstructive Jaundice Associated With Chronic Pancreatitis, C. Grodsinsky, M. A. Block

Henry Ford Hospital Medical Journal

Persistent obstructive jaundice due to stenosis of the distal common bile duct by chronic pancreatitis has been documented in 13 patients of 253 for whom the diagnosis of chronic pancreatitis has been established. All 13 cases required operation; obstructive jaundice was present at surgery in nine; four had recurring jaundice for prolonged periods. None had associated biliary lithiasis. All cases showed evidence of excess alcohol intake. The jaundice, often associated with mild to moderate pain, was disabling and life-endangering and was relieved by operation. In these patients carcinoma must always be ruled out by diagnostic studies, operation, and the elapse …

1980 Beaumont Lecture: Restriction Enzymes As Tools For Genetic Research, Hamilton O. Smith

Henry Ford Hospital Medical Journal

No abstract provided.

Danazol Therapy In Hereditary Angioedema, Lawrence C. Sweet, Charles E. Jackson, Sam S. Yanari, J. B. Yott

Henry Ford Hospital Medical Journal

Herditary angioedema (HAE) is an autosomal dominantly inherited condition in which a deficiency of the inhibitor (C1lnh) of the activated first component of complement is associated with recurrent episodes of edema of the skin, gastrointestinal tract, and larynx. The pituitary gonadotropin inhibitor, danazol, has been reported to be effective in preventing attacks and increasing C1lnh levels. Our experience with 11 patients from five kindreds corroborated those results and has revealed that most patients can be maintained symptom-free on 100-200 mg of danazol daily Side effects were minimal, although one young woman discontinued therapy because it aggravated her acne. The elevation …

Henry Ford Hospital Clinicopathological Conference: Metamorphosis In Chronic Granulocytic Leukemia In A 60-Year-Old Man

Henry Ford Hospital Medical Journal

No abstract provided.

Dissecting Aneurysm Of Aorta Complicating Coarctation Of The Aorta: Case Report And Brief Literature Review, Remigio Garcia, Julius M. Ohorodnik, Donald J. Magilligan Jr.

Henry Ford Hospital Medical Journal

The incidence of dissecting thoracic aorta aneurysm complicating coarctation of the aorta ranges from 1.7 to 23% in large series of coarctation of the aorta reported. In a review of 95 cases of dissection of the aorta, we found only one case with associated coarctation of the aorta. The presence of this anomaly, although rare, should be suspected and searched for in younger patients with dissection, in view of the surgical implications at the time of correction.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

A Developmental Analysis Of Attentional Processes In Educabley Mentally Retarded And Normally Developing Children, Ronald T. Brown

Integrated Health Sciences Faculty Research

No abstract provided.

Adjustment To Psycho-Social Stress, John William Carnes

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study was to determine the relationship between adjustment to life-event stressors and selected psycho-social variables. Recent research has consistently identified an etiological link between stressful life-events and physical and/or emotional disorders. It has often been noted, however, that exposure to seemingly identical stressors results in varying levels of adjustment among individuals. Lazarus (1966, 1967, 1971, 1974) has proposed that variations in stress responses are attributable to differences relative to the implicated individual's appraised threat from the stressor. Based on this conceptualization, adjustment to stressful life-events was selected as the dependent variable for the study. Five independent …

Legal Representation Of The Mentally Ill, James R. Elkins

West Virginia Law Review

The "rights revolution," sparked by the United States Supreme Court under the leadership of former Chief Justice Earl Warren, has abated as the Court modifies and in some instances emasculates the constitutional rights afforded criminal defendants. While the Supreme Court assumes a more “moderate" position regarding the rights of criminal defendants and takes a closer look at due process decisions generally, the "rights revolution" has had substantial spillover effect in the case of individuals confined involuntarily in mental institutions. The courts, especially federal courts, have recognized the constitutional basis of procedural and substantive safeguards for individuals subject to commitment in …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Cumulative Index, 1973-1979

Henry Ford Hospital Medical Journal

No abstract provided.

A Method For Evaluating The Platelet Surface Response By Using Electron Microscopy, Jeanne M. Riddle

Henry Ford Hospital Medical Journal

Our method for evaluating the surface response of any given platelet population, which has evolved over the past two decades, provides a measure of both the adhesive and cohesive qualities of platelets. General morphologic features of the adherent, whole platelets can be assessed by transmission electron microscopy, and the results are reproducible when serial samples are collected on normal subjects and patient groups. With this technique, different metabolites and drugs can be combined with platelet populations that are either normoresponsive or hyperactive to determine if these substances trigger or inhibit the platelet response. To date, the results from in vitro …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Role Of High Molecular Weight Kininogen (Fitzgerald Factor) In The Activation Of Various Plasma Proteolytic Enzyme Systems, R. Waldmann, A. G. Scicli, J. Guimaraes, G. Scicli, Oscar A. Carretero, H. Kato, Y. N. Han, S. Iwanaga

Henry Ford Hospital Medical Journal

Bovine high molecular weight kininogen (bHMWK) partially corrects the aPTT of Fitzgerald-trait plasma, which is congenitally deficient in HMWK. The relationship between the structure and activity of HMWK was clarified by studying the effects of different fragments of bHMWK on the aPTT of Fitzgerald-trait plasma. The peptides studied, all in equimolar concentrations, were lys-bradykinin-free HMWK, bradyk In In-fragment 1-2-tree HMWK, heavy chain, fragment 1 -2-Hght chain, and light chain. Bradykinin- fragment 1-2-free HMWK, heavy chain, and light chain have little or no correcting activity upon Eitzgeraldtrait plasma aPTT. Fragment 1-2 light chain has the same correcting activity as intact bHMWK, …

The Role Of Exercise And Nutrition In The Rehabilitation Of The Geriatric, Robert R. Ladd

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract not included]

The Management Of Iatrogenic Chylous Ascites, Joseph W. Lewis, Edward H. Storer

Henry Ford Hospital Medical Journal

Iatrogenic chylous ascites, although extremely rare, appears to follow direct lymphatic injury during intra-abdominal surgery or to be due to specific postoperative complications such as pancreatitis. Statistically, truncal vagotomy has produced the largest number of cases. Any noticeable lymphatic injuries at the time of surgery should be controlled with appropriate sutures or clips. If iatrogenic chylous ascites develops postoperatively, a course of conservative treatment including multiple paracenteses should be tried for several weeks if reasonable nutritional balance can be maintained. If fluid volume does not diminish or the patient's nutritional status is jeopardized, early exploration should be undertaken. A lipophilic …

Portal Hypertension In Children: Three Case Reports And Review Of Recent Progress In Treatment, Philip J. Howard

Henry Ford Hospital Medical Journal

The diagnosis and surgical management of extrahepatic portal hypertension in infants and children have improved dramatically in the last 50 years, as evidenced by the reported mortalities of 46% in 1928-1935 and only 12% in 1974. The diagnosis Is often evident from the first sudden gastrointestinal bleeding Incident and can be verified quickly with fiberoptic esophagoscopy and x-rays. The surgeon has a choice of multiple shunt procedures to control portal pressure.

1978 Publications Of The Staff Of Henry Ford Hospital

Henry Ford Hospital Medical Journal

No abstract provided.