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Effects Of Various Hormones On Human Carcinoma Cell Proliferation, Y. L. Gao, B. S. Leung, A. H. Potter, W.C.Y. Yu

Journal of the Minnesota Academy of Science

Cell proliferation of a mammary adenocarcinoma cell line, CAMA-1. is affected by a number of steroid hormones and prolactin in long-term cultures. Estrogenic compounds stimulate cell growth while antiestrogenic compounds inhibit it. Prolactin can synergize the estrogenic effect. Progesterone, glucocorticoid or androgen reduce cell proliferation. Dihydrotestosterone is a very potent inhibitor,- effective at as low as 10 nM, and its effect is independent of estrogen action. Cortisol is a less effective inhibitor at concentrations below 10 nM; at these levels cortisol exhibits a slight inhibition which appears to be unrelated to estrogenic action. However, at higher concentrations, cortisol markedly reduces …

The Effect Of Cardiac Rehabilitation On Blood Lipids, Carol Lynn Bartholomew

MUSC Theses and Dissertations

The effect of cardiac rehabilitation on blood lipids was studied in a sample of seventeen male participants of the Greenville Hospital Center cardiac rehabilitation program. These subjects all suffered myocardial infarctions, but none had surgery to by-pass the obstructed coronary circulation. Paired values were obtained for triglyceride, serum cholesterol and HDL cholesterol before, and after the exercise program. The time span between the before-exercise and after-exercise values ranged from five to thirty-one weeks. The differences in the paired values were analyzed by the t-test. No significant decrease occurred in triglyceride or serum cholesterol. A significant increase occurred in HDL cholesterol.

Newsletter, Volume 27, Number 01, January - February 1982

Newsletter: A Report to Physicians of Texas Archives

• Psychiatric treatment Addresses chronic Pain and Depressive Illness
• Murgola represents UT MDAH at Workshop on Genetic Translational Accuracy
• Conference to Focus on Psychological Implications of Chronic Illness in Children
• Hybridoma Conference Aimed at Divers Audience of Biological Scientists
• Noteworthy
• Peters Joins Staff as Head of Radiotherapy
• Guidelines Developed for Drug Preparation
• Guidelines for Handling Antineoplastic Agents
• Three Books Published
• Wataru W. Sutow Dies
• New Staff Appointments

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1931-1982) T1501-T1600, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1501. TRANSLATION FROM RUSSIAN. LEONOV, Yu. A. and KHARITONOVA, N. N. (1972). Experimental confirmation of the role of root voles in epizootiology of Omsk hemorrhagic fever. In: Transcontinental associations of migratory birds and their role in distribution of arboviruses, edited by Cherepanov, A. I. Mater. 5. Simp. Izuch. Roli Pereletn. Ptits Rasp. Arbovirus. (Novosibirsk, July 1969), pp. 355-358.

T1503. TRANSLATION FROM RUSSIAN. GASANOV, A. A. (1963). The infection of Rhipicephalus bursa (Can. et Fanz., 1877) with Babesia ovis in the Nakhichevan Region of the ASSR. Izv. Akad. Nauk Azerb. SSR, s. Biol. Med. Nauk, (4):117-123.

T1504. TRANSLATION FROM RUSSIAN. TSAPRUN, …

Combined Heat And X-Ray Treatment Of Experimental Tumours, J. Denekamp, S. A. Hill, F. A. Stewart

Henry Ford Hospital Medical Journal

No abstract provided.

An Updated Analysis Of Microwave Hyperthermia At 2450 Megahertz And 915 Megahertz Frequencies, Kenneth H. Luk

Henry Ford Hospital Medical Journal

No abstract provided.

Glucose Metabolism In Liver And An Adenocarcinoma Of Mice With And Without Hyperthermia, Christian Streffer, Sieglinde Hegstebeck, Peter Tamulevicius

Henry Ford Hospital Medical Journal

No abstract provided.

The Effect Of Theophylline On Intestinal Bicarbonate Transport Measured By Ph Stat In Amphiuma, Michael A. Imon, John F. White

Department of Anesthesia Faculty Articles

1. The influence of theophylline on the mucosa to serosa and serosa to mucosa fluxes of HCO3- were measured by the pH stat technique in isolated segments of proximal small intestine from Amphiuma maintained under short-circuited conditions. The mucosal or serosal fluid was exposed to media containing 25 mM-HCO3- (pH 7.4) while the pH of unbuffered media in the opposite compartment was maintained by addition of acid. 2. Theophylline significantly increased the secretory flux of HCO3- and significantly reduced the absorptive flux when measured in Cl- -free (SO4(2-)) media. 3. In normal media theophylline did not alter the secretory flux …

Hyperthermia, F. K. Storm

Henry Ford Hospital Medical Journal

No abstract provided.

Local Microwave Hyperthermia In Cancer Therapy. Preliminary Report, Carlos A. Perez, Walter Kopecky, Robert Baglan, D. Venkata Rao, Richard Johnson

Henry Ford Hospital Medical Journal

No abstract provided.

Newsletter, Volume 26, Number 06, November - December 1981

Newsletter: A Report to Physicians of Texas Archives

• UT System Board of Regents Approves Construction, Establishes New Chairs
• Patients and Staff Benefit from Time and Skills Offered by More than 750 Volunteers
• Noteworthy
• Hilkemeyer Recognized for Work in Oncology Nursing
• Researchers Continue Careful Exploration of Tuftsin’s Potential as an Anti-Cancer Agent
• Dr. Clark Receives Board of Visitors Award
• UT MDAH Offers Summer Biomedical Cancer research Program for College Students
• Leon L. Dmochowski, Emeritus Professor of Virology, Dies at 72

The Polytetrafluoroethylene (Ptfe) Graft For Portacaval Interposition: An Experimental Observation, Alexander G. Yap, George Isshak, Ronald Lam, Roger F. Smith

Henry Ford Hospital Medical Journal

In an attempt to determine the efficacy of the polytetrafluoroethylene (PTFE) graft as a portacaval interposition shunt, 26 mongrel dogs were randomly selected to receive a side-to-side shunt with a 6 mm, 8 mm, or 10 mm PTFE graft after portal hypertension had been created by hepatic vein ligation. The dogs were clinically observed, and if they showed signs of graft occlusion, they were reexplored surgically. The 6 mm graft had a 0% patency rate; the 8 mm graft had a 28.6% patency rate; and the 10 mm graft had an 87.5% patency rate. Histological examinations revealed adequate incorporation of …

Henry Ford Hospital Clinicopathological Conference: Encephalopathy And Renal Failure In A Three-Month-Old Infant

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Newsletter, Volume 26, Number 04, July - August 1981

Newsletter: A Report to Physicians of Texas Archives

• Henderson Highlights Recent Research in cancer Etiology and Prevention
• Patient and Family Library Expands
• Science Park Hosts Meetings on Primatology
• UT MDAH Staff Publish Three News Books
• Noteworthy
• A. Clark Griffin Assumes Leadership of UT Science Park’s Research Division
• International Colloquium to Look at Cancer Patient Care Today and in 2001
• UTSCC Well Represented at ASCO/AACR Meeting
• New Staff Appointments
• Dr. Richard Doll Questions the Existence of a General Cancer Epidemic
• Gilbert Fletcher Honored in Granada

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Vital Signs, June 1981, Boonshoft School Of Medicine

Vital Signs

A sixteen page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Environmental Enrichment And Nursing Therapy With Comatose Patients : Two Case Studies, Marilyne R. Sayler

Loma Linda University Electronic Theses, Dissertations & Projects

As a part of a larger research project with comatose patients the problem stated for this portion of the research study was to investigate the potential for identifying whether or not the quality of nursing care for comatose patients could be improved by nursing therapy with environmental enrichment and meaningful systematic orienting stimuli given by professional nurse clinicians and a patient's significant others. The effects of the orienting stimuli were measured by observable changes in arousal patterns in serial electroencephalograms (EEGs) , level of arousal as scored on the Glasgow Coma Scale (GCS), and selected measures of recovery outcome (RO). …

Intestinal Bicarbonate Secretion In Amphiuma Measured By Ph Stat In Vitro: Relationship With Metabolism And Transport Of Sodium And Chloride Ions, Michael A. Imon, John F. White

Department of Anesthesia Faculty Articles

1. Isolated Amphiuma small intestine exposed on both surfaces to buffered or unbuffered media generated gradients of pH under short-circuited conditions consistent with secretion of HCO3(-). 2. When unbuffered mucosal medium was maintained at pH 7.4 by addition of acid, alkalinization of the mucosal medium occurred at a rate of 1-2 microequiv/hr cm2 under short-circuit conditions (Isc) and was reduced by anoxia, acetazolamide or removal of CO2. 3. The rate of HCO3(-) secretion (JHCO3(-)) was reduced at a mucosal pH above or below 7.4 and was proportional to serosal HCO3(-). 4. JHCO3(-) was reduced in Na+-free (choline) and Cl-free (SO4(2-) …

Vital Signs, May 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Newsletter, Volume 26, Number 03, May - June 1981

Newsletter: A Report to Physicians of Texas Archives

• Cyclotron Will Provide New Research and Treatment Opportunities
• Conference Focuses on Nursing and Cooperation Among Disciplines in Pediatric Oncology
• Scientists Investigate the Links Between Nutrition and Cancer at 34th Symposium
• Two New Books Published
• UT MDAH Announces New Referral Guide
• Louise C. Strong Appointed to Killam Professorship
• Nationwide Hotline Offers Oncology Nursing Expertise
• New Professorship Named in Honor of R. Lee Cark

Vital Signs, April 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1981), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1981 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Report of the Capital Campaign
• Neurosensory Diagnostic Center
• Faculty Notes
• News from the College
• News from the Hospital
• Tour of 4190
• Nurses Alumnae Banquet
• Bookstore
• Synapsis '82
• Spring Sports
• Worth Mentioning
• New Appointments
• From the Alumni Office
• Alumni News Briefs
• In Memoriam
• Founders Day Schedule

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Local Hyperthermia And Radiation: A Biologically-Oriented Clinical Scheduling, G. Arcangeli, A. Cividalli

Henry Ford Hospital Medical Journal

In a series of animal tumor studies, heat was directly delivered into the tumor mass with an interstitial applicator. After hyperthermia (44°-45°C for 45 minutes) or radiation alone (3x10 Gy), only a slight delay in tumor growth was observed, while the combined treatment, either simultaneous or sequential (i.e., heat delivered four hours after irradiation), appeared to be the most effective. The cure rate in the two combined treatment groups was 100%, in contrast to the lack of cure in the first two groups. The simultaneous use of heat and x-ray appeared to be slightly more effective than the sequential schedule; …

Glucose Metabolism In Mouse Tumor And Liver With And Without Hyperthermia, Christian Streffer, Siegelinde Hengstebeck, Peter Tamulevicius

Henry Ford Hospital Medical Journal

We measured levels of glycolytic metabolites in mouse tumor and liver after administering a glucose load of 6 mg/g of body weight and after hyperthermia for one hour at 43°C. Metabolites included glucose, glucose-6-phosphate, fructose-1.6-diphosphate, dihydroxyacetone-phosphate, glycerol-3-phosphate, pyruvate, and lactate, as well as acetoacetate and β-hydroxybutyrate. The combined treatment led to an increase of the lactate level and apparently enhanced glucose degradation. The redoxequilibria states were shifted to the reduced metabolites. It is possible that hypoxia was induced or enhanced, which could have significance for tumor therapy. At later periods after hyperthermia, metabolic alterations occurred that have also been observed …

Hyperthermia, F. K. Storm

Henry Ford Hospital Medical Journal

This report describes the history of hyperthermia and reviews current forms of treatment at both low (42°-43°C) and higher (<45°C) temperatures. Hyperthermia treatment at low temperatures includes fluid immersion and irrigation, regional perfusion with heated fluids, and electromagnetic radiofrequency waves. Low-temperature hyperthermia has also been combined with radiation therapy and with chemotherapy in recent clinical trials. At higher temperatures, we and other investigators have also had promising, preliminary results in treating tumors safely. With the specialized radiofrequency instrumentation we have developed to apply hyperthermia at any depth without preferential surface tissue heating, further clinical investigation of both superficial and deep internal solid tumors is now possible. Recent data suggest that hyperthermia may be an especially effective form of therapy for larger tumors that resist standard forms of treatment. Clinical trials are now underway to determine the most therapeutic dose/time regimen, to determine toxicity and therapeutic enhancement ratios of combined chemotherapy and x-irradiation with hyperthermia, and to evaluate any changes in the host immune system with such therapies.

Local Microwave Hyperthermia In Cancer Therapy: Preliminary Report, Carlos A. Perez, Walter Kopecky, Robert Baglan, D. Venkata Rao, Richard Johnson

Henry Ford Hospital Medical Journal

This report summarizes our preliminary experience at the Mallinckrodt Institute of Radiology treating 26 patients with metastatic tumors with hyperthermia and irradiation. Patients received 400 rad fractions given every 72 hours (twice weekly) for a total of 2400, 2800, 3200, or 4000 rad followed by hyperthermia. In addition, 18 lesions were treated according to a protocol designed by the Radiation Therapy Oncology Group (RTOG) for superficial measurable tumors to receive three doses of 500 rad followed by hyperthermia (six lesions) or irradiation alone (three doses of 600, 700, or 800 rad) every 72 hours. Hyperthermia was administered with 2450 MHz …

Microwave Hyperthermia At 2450 And 915 Megahertz Frequencies, Kenneth H. Luk

Henry Ford Hospital Medical Journal

Microwave hyperthermia at frequencies of 2450 and 915 megahertz (MHz) was used to treat superficial measurable tumors of different histopathologies at various sites. Forty-seven patients received 59 courses of treatment; they were able to tolerate temperatures up to 42.5X1. Although hyperthermia alone (40°-42.5°C) did not produce an effective response, hyperthermia and radiation together (up to 2700 rad in nine fractions over three weeks) produced complete and partial responses in three-fourths of the treatment courses. The combination of hyperthermia and chemotherapy may have great potential, but confirmation of these clinical impressions will depend on a much larger series of patient data. …

Hyperthermia Treatment Of Experimental Tumors, J. Denekamp, S. A. Hill, F. A. Stewart

Henry Ford Hospital Medical Journal

The therapeutic advantage of combining hyperthermia with x-irradiation to treat tumors depends on whether or not it is possible to achieve greater thermal sensitization of tumors than of normal tissues. To determine such therapeutic gain factors (TGE), we assessed the response of mouse skin and seven transplantable mouse tumors to graded x-ray doses given alone or combined with moderate heat (42.5°C for 60 minutes). We constructed dose response curves for the average early skin reaction and for the induced delay in tumor regrowth to an arbitrarily chosen size. We studied the following areas: 1) the therapeutic gain of combining heat …