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Oncolog, Volume 28, Number 01, January-March 1983, The University Of Texas Md Anderson Cancer Center, James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Newsletter Becomes OncoLog
• Prolactinoma, a Prevalent Gonadoinhibitory Tumor, Responds Well to Treatment
• Laboratory Research Continues to Advance Methods of Cancer Diagnosis and Therapy
• Radiotherapy Plays Vital Role in Treatment or Patients with Malignant Parolld Tumors

Serial Cardiovascular Adaptations During Pregnancy, Mark Vincent Hart

Dissertations and Theses

Maternal cardiovascular adaptations appear to be essential in order to supply extra circulation to both the developing fetus and maternal system during a successful pregnancy. Since inadequate cardiovascular adjustments may produce abortions or maternal morbidity, the characterization of maternal cardiovascular changes during pregnancy and the elaboration of the underlying mechanism for these changes are essential to the understanding of how the heart enlarges during pregnancy and what significance this enlargement might have. To provide needed information regarding this time course and extent of maternal cardiac enlargement and the hormonal and hemodynamic changes which may be responsible for these changes, the …

Protein Contributions Of The Male Accessory Organs To The Composition Of Human Seminal Plasma As Determined By High Resolution Two-Dimensional Electrophoresis, Edward E. Gaunt

Theses and Dissertations in Biomedical Sciences

Human Seminal Plasma was evaluated using a High Resolution Two-Dimensional Electrophoresis technique adapted by this laboratory. Seminal plasma from healthy volunteers with recently proven fertility were characterized using this technique to establish "normal" protein distribution patterns in the two-dimensional polyacrylamide gel slab. In addition, time studies were performed on selected specimens to determine the effects of liquefaction on seminal plasma protein composition within the first several hours after collection. Split ejaculates were collected for identification and elaboration of accessory organ components in the whole seminal plasma specimen. A more direct approach to accessory organ component analysis involved electrophoresis of semen …

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1915-1983) T1601-T1700, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1603. TRANSLATION FROM RUSSIAN. SELIVANOV, Ya. M. and POLYAKOVA, A. N. (1981). Technic of preparing and producing experimental series of immunoglobulin erythrocytic polytype diagnosticums to certain arboviruses for the indirect hemagglutination test. Sborn. Trud. Inst. Virus. imeni D. I. Ivanovsky, Akad. Med. Nauk SSSR, pp. 145-151.

T1604. TRANSLATION FROM RUSSIAN. ROSLAYA, I. G., DEMENEV, V. A., PRYGOVA, A. I., ROSLYAKOV, G. E. and VERETA, L. A. (1981). Certain questions of ecology of tickborne encephalitis group viruses in the lower Pre-Amur'ye. Sborn. Trud. Inst. Virus. imeni D. I. Ivanovsky, Akad. Med. Nauk SSSR, pp. 90-94.

T1605. TRANSLATION FROM RUSSIAN. EMEL'YANOVA. N. …

The Development And Evaluation Of A Seminar For Teachers On The Awareness And Management Of Allergic Conditions Of Their Students In The Classroom, Elwin C. Munson

Dissertations

Problem. Many children with allergic problems go without treatment because their problems go unrecognized by both their parents and teachers. The purpose of this project was to bring about change on the part of teachers enabling them better to address allergic problems in their students. Literature was reviewed with respect to allergies and with respect to the use of inservice seminars for teachers. The posttest means for all three areas of measurement of the seminar group and control group were adjusted for pretest scores by analysis of covariance which indicated a significant difference in favor of the seminar group in …

Ua12/2/1 College Heights Herald, Vol. 58, No. 29 Magazine, Wku Student Affairs

WKU Administration Documents

Special magazine issue of the College Heights Herald. This issue contains articles:

• Mitchell, Cyndi. Being With Hospice of Bowling Green
• Wright, Sharon. The Two Week Semester - Will It Ever End?
• Smith, Erica. A Social Awareness - Dean Nason

The Measurement Of Human Chorionic Gonadotropin For Pregnancy Testing, Carolyn S. Feldkamp, William H. Pfeffer

Henry Ford Hospital Medical Journal

/Among many measurable hormones, human chorionic gonadotropin (FICG) is commonly used for pregnancy testing because it is very sensitive and relatively specific. Pregnancy can be identified shortly after implantation. Because some reagents cross-react with luteinizing hormone (LH), the sensitivity of urine tests has been adjusted to maintain specificity. Radioreceptor assay s on serum are more sensitive than urine tests but similarly lack specificity. The problems of LH cross-reactivity are eliminated by antisera specific for the beta subunit. Quantitation of HCG provides additional information useful in diagnosing ectopic pregnancy, providing a prognosis in threatened abortion, and following neoplasms. Considerations of cost, …

Echocardiographic Identification Of Left Ventricular Cavity Obliteration, Vidyadhar R. Gandra, Mohsin Alam, Fareed Khaja, Sidney Goldstein, Jeffrey B. Lakier

Henry Ford Hospital Medical Journal

We identified 22 patients with angiographic left ventricular cavity obliteration (LVCO), of whom 15 were available for M-mode and two-dimensional echocardiographic evaluation. All 15 patients had chest pain, and 13 had long-standing hypertension. Electrocardiographic evidence of left ventricular hypertrophy was present in ten patients. The echocardiographic criterion for LVCO was apposition of the left ventricular septum with the left ventricular posterior endocardium during systole as demonstrated by either M-mode or two-dimensional systems. LVCO was demonstrated during systole by M-mode echocardiography in seven of 15 patients and by two-dimensional echocardiography in 14 patients. LVCO could not be demonstrated in ten randomly …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Newsletter, Volume 27, Number 06, November - December 1982, Gerald P. Bodey Md, Beverly Rosenbaum Ba

Newsletter: A Report to Physicians of Texas Archives

• Protected Environment Successfully Reduces Patients’ exposure to Microbial Contamination
• Gold Rings Provide a Secure Means of Attachment for Prostheses
• Newly Created Positions Reflect High Priority of Institution’s Academic Mission
• William Fields Direct New Neuro-oncology Center
• Noteworthy
• Bruno Jirgensons Dies
• UT MDAH Offers Summer Research Program for College Students

Immunological Involvement In Porcine Bioprosthetic Valve Degeneration: Preliminary Studies, Rollin H. Heinzerling, Paul D. Stein, Jeanne M. Riddle, Donald J. Magilligan Jr., John J. Jennings

Henry Ford Hospital Medical Journal

Preliminary animal model studies have indicated that porcine bioprosthetic valves can be recognized by the immune system. This report presents the results of a preliminary investigation on the implanted valves of 27 patients. While none of the 27 demonstrated an immune response to porcine serum proteins, five patients developed antibodies against the implanted valve leaflets. Cells were enzymatically eluted from a degenerated bioprosthetic valve and were classified by means of monoclonal antibodies. Although these cells were not found to be of T-lymphocyte lineage, they did express la determinants and had the morphologic appearance of plasma cells. We therefore conclude that …

A Morphologic Overview Of The Porcine Bioprosthetic Heart Valve, Jeanne M. Riddle, Paul D. Stein, Donald J. Magilligan Jr.

Henry Ford Hospital Medical Journal

The glutaraldehyde-processed porcine aortic heart valve is similar in its microscopic organization to the human aortic valve (1). It is important to understand the detailed histology of this bioprosthetic valve because distinct components of its leaflets are altered selectively when the valve is initially collected from the pig and stabilized with the commercial glutaraldehyde fixation process. Further structural modifications also occur after the commercially processed valve has been inserted into a patient where it undergoes progressive degeneration.

Observations Suggesting A Possible Link Between Gammacarboxyglutamic Acid And Porcine Bioprosthetic Valve Calcification, Joseph A. Helpern, Stephen J. Mcgee, Jeanne M. Riddle

Henry Ford Hospital Medical Journal

Observations that link gammacarboxyglutamic acid (Gla) peptides with ectopic calcification are accumulating in the literature and may be summarized as follows: 1) Gla peptides selectively bind calcium and hydroxyapatite. 2) The presence of detectable levels of Gla in calcified tissue is concurrent with the onset of mineralization. 3) In an animal model, osteocalcin (a Gla-containing protein) accounts for more than 90% of all the Gla found in the resulting subcutaneously implanted calcified leaflet. 4) Vitamin D stimulates osteocalcin synthesis in cultures of osteosarcoma cells, and in vitamin D deficient rats subcutaneously implanted valve leaflets are not calcified. 5) Gla content …

Editorials

Henry Ford Hospital Medical Journal

No abstract provided.

Blood Reservoir Function Of The Fetal Guinea Pig Liver, Gregory A. Roda, Raymond D. Gilbert, Gordon G. Power

Loma Linda University Electronic Theses, Dissertations & Projects

To determine of the fetal liver functions as a blood reservoir, we measured liver blood volume under normal conditions and after hemorrhage and volume loading. Nineteen pregnant guinea pig sows and 54 near-term fetuses were injected intravenously with ⁵¹Cr-labeled red cells while the fetuses remained in utero. Ninety seconds later a 0.5-1.0 g sample of liver was garroted with a sharp wire into a tared tube with minimal blood loss. A blood sample was taken to measure counts per ml of blood, the fetus killed and the remainder of the liver weighed. Blood volume of the liver and body …

Vital Signs, Summer 1982, Boonshoft School Of Medicine

Vital Signs

A six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Newsletter, Volume 27, Number 04, July - August 1982, Hwee-Yong Yap Md, George R. Blumenschein Md, Frank C. Schell Md, Aman U. Buzdar Md

Newsletter: A Report to Physicians of Texas Archives

• Rehabilitation Program Designed to Address Needs of Patients with Sexual Dysfunctions
• 26th Annual Clinical conference Will Examine Controversies Surrounding Breast Cancer
• Three Books Published
• Researchers Identify Promising New Drug for the Treatment of Metastatic Breast Cancer
• Brown Foundation Honors Outstanding Nurses
• Students Explore career Opportunities in the Biomedical Sciences
• Noteworthy
• Facilities Names in Honor of John S. Dunn, Sr.
• New Staff Appointments

Effect Of Levamisole On The Incidence Of Spontaneous Mammary Tumors In C3h Mice, Robert H. Page, Duilio A. Valdivia, Robert W. Talley, Robert A. Huseby

Henry Ford Hospital Medical Journal

Spontaneous mammary carcinoma in C3H mice is preceded by premalignant hyperplastic alveolar nodules. When a primary tumor is evident, examination of the other mammae will reveal a number of microscopic precancerous lesions in various stages of transformation to overt malignant tumors. In an effort to inhibit the development of additional malignant tumors after surgical removal of the first apparent tumor, we treated female C3H/HeJ mice with subcutaneous injections of levamisole (0.6 mg per kg of body weight) on a twice weekly regimen. All further tumors were surgically excised when they became palpable. The surgical excision of bulk tumor burden, immunorestoration …

The Central Surgical Association Turns Forty: Some Highlights Of The First Twenty Years, Conrad R. Lam

Henry Ford Hospital Medical Journal

The Central Surgical Association assembled for the first time in Detroit and Ann Arbor, Michigan in February, 1941. On the 40th anniversary of this meeting, the Association met again in the same geographical region, in Dearborn. Selected papers from the first twenty years have been chosen as highlights. Criteria for choosing a few from many significant papers were the originality of the material, its time-proven value, and the subsequent impressive careers of the authors. Appropriate credit is given to Dr. Roy D. McClure for his concept of an organizadon of surgeons in the central geographical area and for his efficient …

Editorials, Raymond H. Kahn, Michael Kleerekoper, Irwin K. Rosenberg

Henry Ford Hospital Medical Journal

No abstract provided.

Observation Of Bone Formation In The Mandibular Symphysis Following Surgical Separation And Slow Mechanical Expansion In A Baboon, Robert J. Homer

Loma Linda University Electronic Theses, Dissertations & Projects

Mechanical expansion of the maxilla, at the midline suture, is a widely accepted orthodontic procedure used to gain arch width in certain types of maxillary deficient arches.

In animal research on the mandible, techniques using surgical separation at the symphysis with immediate expansion up to 12 mm, fixation with a metal splint, and autogenous bone transplanted into the expanded area, have been reported to be successful.

To date, no experiment utilizing slow mechanical expansion of the mandible at the symphysis has been reported.

In this pilot study, the mandible of a female baboon was surgically separated A-P at the symphysis. …

Newsletter, Volume 27, Number 03, May - June 1982, Louise C. Strong Md

Newsletter: A Report to Physicians of Texas Archives

• UT MDAH Maintains High Cure Rate, Low Recurrence Rate for Rare Uterine Cancer
• UT MDAH Offers Oncology Lecture Series
• Biomathematicians Develop Software for Clinical Trial Design and Analysis
• Lectureship Honors Taylor
• Murray M. Copeland Dies
• Genetic Markers May Identify Chromosomal Deletion Associated with Retinoblastoma, Louise C. Strong, MD
• Noteworthy

The Immunology Of Inflammatory Bowel Disease, Hugh L. N. Mackechnie

Henry Ford Hospital Medical Journal

Although several measurements of both cellular and humoral immunity are altered in inflammatory bowel disease (IBD), no direct pathogenic role can be confirmed in either ulcerative colitis (UC) or Crohn's disease (CD). No clear role has been shown for allergic, microbiological, or psychogenic factors, and no specific genetic susceptibility has been demonstrated. Several studies have shown some benefit from using immunosuppressive drugs to treat inflammatory bowel disease, such as sulfasalazine to treat ulcerative colitis and corticosteroids to treat Crohn's disease. Whether these benefits derive from the anti-inflammatory activity of these drugs or from their immunological effects is uncertain.

Zoonoses In Modern Medical Practice, Tom Madhavan

Henry Ford Hospital Medical Journal

Zoonoses are infections transmitted by animals to man. Of the more than 50 such infections that are clinically significant, several are discussed in the articles by McIntosh and Madhavan and by Meyer and Adar in this issue of the Journal (pp. 7-13). These include brucellosis, leptospirosis, relapsing fever, Colorado tick fever, toxoplasmosis, psittacosis, and echinococcosis. The McIntosh and Madhavan article reviews the experience at Henry Ford Hospital with 60 patients, while the article by Meyer and Adar reports on an unusual case of echinococcosis of the spine and retroperitoneum that occurred at Haim Sheba Medical Center in Israel.

Zoonoses At Henry Ford Hospital: Clinical, Epidemiologic, And Therapeutic Aspects, Nancy Mcintosh, Tom Madhavan

Henry Ford Hospital Medical Journal

Zoonoses are diseases of animals that can be transmitted to humans. We reviewed the experience with zoonotic illnesses treated at Henry Ford Hospital in the past ten years. Included in this report are cases of brucellosis, leptospirosis, relapsing fever, Colorado tick fever, toxoplasmosis, psittacosis, and pasteurellosis. This report describes the clinical and epidemiologic aspects of zoonoses in 60 patients in a large urban general hospital.

Echinococcosis Of The Spine And Retroperitoneum: Case Report And Review Of The Literature, Eugene Meyer, Raphael Adar

Henry Ford Hospital Medical Journal

Echinococcosis is a zoonosis transmitted from sheep dogs to humans. It occurs most frequently in sheep and cattle-raising countries, and children who come in contact with sheep dogs are the most likely victims. The liver and the lungs are the most common sites of the hydatid cysts. Their presence in other organs is less common, and primary hydatidosis of the retroperitoneum is extremely rare. In the case reported here, a 65-year-old man had secondary retroperitoneal echinococcosis that recurred three times in 23 years. On the third occasion, marsupialization was performed on a large cyst found in the right retroperitoneum.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Vital Signs, February 1982, Boonshoft School Of Medicine

Vital Signs

A six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Administration Documents

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Garvin, Catherine. The Recognition of Anticipatory Grieving and Associated Needs of the Family of a Critically Ill Patient
• Parks, Barbara. Energy Properties of Textiles
• Martin, Lanna. A Historical Approach to the Understanding of Civil Disobedience
• Atwood, Tammy. The Computer Manufacturing Industry and the Burroughs Corporation
• Allen, Christopher. The Battle of Marathon: Athens' Magnificent Triumph
• Martin, Lanna. Melville's Creation of Captain Vere as Pontius Pilate in Billy Budd
• Boles, Barbara. Emerson's Uriel and the …

Immunological Approaches To The Diagnosis Of Systemic Candidiasis, Gene Elizabeth Burges

MUSC Theses and Dissertations

The increasing incidence of systemic candidiasis and the difficulties diagnosing the disease on the basis of clinical data and culture results have prompted investigation into immunological methods of diagnosis. Detection of anti-Candida antibodies has proved to be not sufficiently specific for diagnosis of systemic disease since antibodies are frequently found in the normal individual in whom the organism lives as a commensal and in superficially infected individuals. Our project resulted in the development of a new quantitative immunofluorescence assay for quantitation of anti-Candida antibodies which is able to differentiate quite well (p< 0.0005) between systemically infected patients and normals or superficially infected patients. We have also investigated the value of purified antigens and have shown that the use of cytoplasmic protein antigens rather than those containing cell wall polysaccharide confers greater specificity on a qualitative test for anti-Candida antibodies but that a carbohydrate-containing antigen is adequate for differentiating systemic disease when a quantitative test is used. Attempts to diagnose systemic candidiasis by detection of circulating antigen have met with varying degrees of success. We were unable to detect antigen by counter-immunoelectrophoresis, a quantitative immunofluorescence inhibition assay, or an ELISA inhibition assay in the sera of rabbits in whom a Candida endocarditis was induced or in the sera of systemically infected patients. One postulated reason for this failure is the presence of the antigen in the form of circulating immune complexes. We have, therefore, investigated the possibility of the existence of complexes containing Candida antigen and antibody in the sera of patients with systemic candidiasis. Using four screening tests, a statistically significant difference (p < 0.05) was found for immune complex levels in a group of patients and a group of normal individuals. Isolation and characterization of immune complex-containing fractions from five patients with candidiasis indicated the presence of anti-Candida antibodies and/or antigen in at least three of them. Therefore, these fungal immune complexes can be assumed to exist and may play a role in the difficulties in detecting circulating antigen and, furthermore, may be involved in the pathogenesis and progression of disseminated candidiasis.