Digital Commons Network^™

Efficacy Of A Home Made Quality Control Serum, Rukbsana Lalani, Ayesha Molla, Mohammad Khurshid

Section of Haematology/Oncology

With increasing automation in Clinical Laboratories, the requirements for quality control material have greatly increased in order to monitor performance. The constant use of commercial control material is not economically feasible for many countries because of non-availability or the high cost of these materials. Here we describe a simple technique to prepare Home Made Quality Control serum using blood from polycythaemic patients. This preparation is stable for about six months without any alterations in the concentration of any of the chemical constituents. Extensive use of Home Made Quality Control sera in our laboratories have saved about 69% of the amount …

The Development Of Pediatrics In The United States, Jay H. Mayefsky

Henry Ford Hospital Medical Journal

No abstract provided.

Vital Signs, December 1988, Boonshoft School Of Medicine

Vital Signs

A sixteen page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Dietary And Hormonal Evaluation Of Men At Risk For Prostate Cancer, Donald J. Pusateri

Loma Linda University Electronic Theses, Dissertations & Projects

Relationships between dietary nutrients and plasma and fecal estrone, estradiol-17β, testosterone, and plasma prolactin levels were studied in young Seventh-day Adventist men: 18 nonvegetarians (NV), 20 lacto-ovovegetarians (LOV), and 15 vegans (V). Blood samples and 3 d dietary records were obtained. Contemporaneously collected diet composites and stool samples were analyzed for fiber. The vegetarians consumed significantly more fiber than the omnivores, while NVs and LOVs consumed more saturated fat than the Vs. Although plasma steroid hormone status did not differ, the Vs had significantly higher fecal estrogen levels than the NVs or LOVs. Plasma prolactin levels were significantly higher in …

Physical Linkage Of The Genes For Platelet Membrane Glycoproteins Iib And Iiia., Paul F. Bray, Greg Barsh, Jean-Philippe Rosa, Xue Ya Luo, Ellen Magenis, Marc A. Shuman

Cardeza Foundation for Hematologic Research

The fibrinogen receptor on human platelets is a prototypic member of the integrin family and is composed of subunit glycoproteins IIb (gpIIb) and IIIa (gpIIIa) in a 1:1 stoichiometric ratio. We have isolated cDNA clones for gpIIb and gpIIIa and localized both genes to chromosome 17. In the current study, several approaches were used to localize and map the genes for gpIIb and gpIIIa. A preliminary evaluation of subchromosomal localization was performed by using a panel of mouse-human somatic cell hybrids that contain different amounts of the long arm of human chromosome 17. Southern hybridization to the DNA of these …

Population Amalgamation And Genetic Variation: Observations On Artificially Agglomerated Tribal Populations Of Central And South America, R Chakraborty, P E Smouse, J V Neel

Faculty, Staff and Student Publications

The interpretation of data on genetic variation with regard to the relative roles of different evolutionary factors that produce and maintain genetic variation depends critically on our assumptions concerning effective population size and the level of migration between neighboring populations. In humans, recent population growth and movements of specific ethnic groups across wide geographic areas mean that any theory based on assumptions of constant population size and absence of substructure is generally untenable. We examine the effects of population subdivision on the pattern of protein genetic variation in a total sample drawn from an artificial agglomerate of 12 tribal populations …

Newer Therapies In Hypercalcemia And Metabolic Bone Disease, Hunter Heath Iii

Henry Ford Hospital Medical Journal

No abstract provided.

The Inhibition Of Bone Formation Occurring Under Weightlessness : The Effect Of Skeletal Unloading On Serum Levels Of A Bone-Derived Growth Factor, Jean D. Sibonga

Loma Linda University Electronic Theses, Dissertations & Projects

A deleterious effect of spaceflight on human health is the loss of bone associated with the prolonged lack of gravitational stress on the skeleton. A potential for bone loss is indicated by the hypercalciuria and decreased heel bone density determined in Skylab astronauts. Histological studies of juvenile laboratory rats in actual spaceflight and in simulation models document a suppression of bone formation with little alteration of bone resorption. The mechanism for net bone loss needs to be defined in order to develop measures for its prevention or correction.

Skeletal growth factors, which may mediate coupling and locally regulate bone volume …

Age-Related Changes In Meissner Corpuscles Of Diabetic Mice As Observed By Electron Microscopy, Vicky R. Ras

Loma Linda University Electronic Theses, Dissertations & Projects

Light touch and low-frequency vibration sense are often impaired in diabetic patients. Meissner corpuscles are distally located mechanoreceptors that respond to these stimuli. Peripheral sensory neuropathy in diabetes progresses from distal to proximal, therefore, Meissner corpuscles are ideally suited to study diabetic neuropathy in the C57BL/Ks (db/db) mouse.

Corpuscles from the forepaw digital pads of 9 diabetic and 9 nondiabetic littermates were studied by electron microscopy. These were divided into 3 age groups; 2.5 months, 10 months, and 17 months old.

Ultrastructural changes observed within various receptor components were myelin figures, multivesicular bodies, vacuoles, basal lamina duplication, abnormal and enlarged …

A [6-14c] Glucose Autoradiographic Study Of The Rat Brainstem Under Hypercapnic And Hypocapnic Conditions: Identification Of Respiratory-Related Regions, Tobey M. Leung

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of systemic hypercapnia on brainstem metabolism were studied with the [6-¹⁴C] glucose autoradiography method. Neuronal pools which are metabolically active take up more [6-¹⁴C] glucose and maybe revealed pictorially as darker areas on autoradiograms. Since a high concentration of carbon dioxide stimulates central chemoreceptors and hence enhances respiratory drive, the darker regions on the autoradiograms may represent regions concentrated with respiratory-related neurons. Two discrete regions in the ventrolateral medulla (a column near nucleus ambiguus and a column in the lateral reticular nucleus) appeared dark and were analyzed with an image processing system, which converted …

Osteoporosis As A Community Health Problem: Lessons Learned From Studying Hypertension, Michael Kleerekoper, Dorothy A. Nelson

Henry Ford Hospital Medical Journal

Campaigns to increase the medical and lay communities' awareness and understanding of the problems of unrecognized and untreated hypertension have led to a progressive decline in morbidity and mortality from hypertension-related diseases. While osteoporosis is also a community health problem, educational and awareness campaigns are still in their infancy and decades may pass before these result in a declining morbidity and mortality from osteoporosis. We identify areas where concepts learned from years of hypertension research might be applicable lo the study of osteoporosis as a community health problem and thereby lessen the time needed to effect a declining morbidity and …

Biophysical Methods For Estimating In Vivo Body Composition: The Determination Of The Adipose Compartment, Luther E. Preuss, Frank P. Bolin

Henry Ford Hospital Medical Journal

The status of the human body's major components (adipose mass, lean mass, body water, etc) and their change with time are of clinical importance. Deviation of these body components from a stable condition may be imposed by nutrition or disease, and a return to the normal body state may be brought about by appropriate medical care. Thus accurate quantitation of these components is an important goal. This field of study can be traced to the early 1800s, with a major thrust starting in the 1940s and continuing lo the present. The last four decades have shown an accelerated development of …

Occurrence Of Alzheimer Disease In Michigan: An Epidemiologic Review Of Rates And Risk Factors, Christine Cole Johnson

Henry Ford Hospital Medical Journal

Alzheimer disease is a progressive degenerative neurological disorder of insidious onset characterized by the deterioration of cognitive functioning. Little is known about the etiology and epidemiology of this condition. The only risk factor consistently associated with Alzheimer disease is advancing age. As the population of the elderly continues to grow, many public agencies, including those in Michigan, are concerned about social, personal, and financial implications and seek estimates of the number of people with dementia. To date, mortality rates based on vital statistics have been noninformative because Alzheimer disease is difficult lo diagnose clinically and has been considered to be …

Decreased Triiodothyronine Binding To The Hepatic Nuclear Thyroid Hormone Receptor In The Diabetic Mouse, Thomas J. Dewind

Loma Linda University Electronic Theses, Dissertations & Projects

The diabetic C57BL/KsJ-db m mouse has abnormal thyroid hormone levels and indications of thyroid hormone resistance. To investigate the basis of these abnormalities, the hepatic nuclear thyroid hormone receptor was extracted with 0.4 M KCl, 1.1 mM MgCl₂, 20 mM Tris/HCl, pH 7.9 from hepatocyte nuclei of normal C57BL/KsJ, heterozygous C57BL/KsJ-db m (db/m), and diabetic C57BL/KsJ-db m (db/db) mice. Normal and heterozygous mice were grouped together as the controls. Triiodothyronine (T₃) binding studies at 4°C using nitrocellulose filtration to separate free T₃ from receptor bound T₃ demonstrated an …

Treatment Of Periodontal Furcation Defects, Michael Martin, Bernard Gantes

Loma Linda University Electronic Theses, Dissertations & Projects

[Note: Three parts in one.]

I. Review of the Literature and Description of a Regeneration Surgical Technique

This report provides an abbreviated review of the literature on treatment and prognosis of periodontal furcation lesions. In addition, it describes a surgical technique designed to accomplish bone regeneration in class II furcation defects, together with the rationale for the development of this procedure. Results of treatment of 30 defects with this technique are presented in a subsequent report (Gantes et al. 1987).

II. Bone Regeneration in Mandibular Class II Defects

A total of 30 mandibular, buccal class II furcation defects were treated …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Department Of Radiology - Annual Report July 1, 1987-June 30, 1988, David C. Levin

Department of Radiology Administrative Documents and Reports

107 page Department of Radiology Annual Executive Summary Report, July 1, 1987 to June 30, 1988, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Table of Contents:

Name of Department and Chairman 1

Department Divisions and Directors 1

Department Faculty 2

Radiology Residents and Fellows 6

Departmental Committees and Memberships 7

Department Organization Charts 9

State of the Department 11

Teaching Programs 23

- A. Teaching Programs for Medical Students and Non-Radiology House Staff 23

- B. Residency Program for Residents in Radiology 25

- C. Training Programs for Fellows 27

Continuing Medical Education (CME) Programs 28

Radiology Grand Rounds …

Oncolog, Volume 33, Number 03, July-September 1988, C. Stratton Hill, Jr. Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Narcotics and Cancer Pain Control
• For Non-small Cell Lung Cancer, Combinations of Surgery, Chemotherapy, and Radiotherapy
• Shared Research Resources Provide Expertise and Cost Savings

Oncolog, Volume 33, Number 01, January-March 1988, Michael J. Wargovich Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Portable Pumps and Controlled Drug Toxicity Keep More Patients Ambulatory and at Home
• Clarifications of Tumor Cell Diversification Bring New Ideas for Stopping the Process
• Chemoprevention of Colorectal Cancer

Pcom Digest Article (Winter 1988) Featuring Dr. Koch, Philadelphia College Of Osteopathic Medicine

Koch Collection, Papers of Richard S Koch, DO

PCOM Digest Article (Winter 1988) Featuring Dr. Koch, the 1988 PCOM Founder's day laureate.

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1988), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1988 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• 1988 O. J. Snyder Medalist
• DOs in the Arts
• Signing Up for More Visibility
• "PCOM Couldn't Have Done it Any Better"
• Alumni Notes
• On Campus
• Class Acts
• In Memoriam
• Calendar

Sensitivity To Ingested Sulfites, Steve L. Taylor, Julie A. Nordlee

Department of Food Science and Technology: Faculty Publications

Sulfiting agents, including sodium and potassium bisulfite, sodium and potassium metabisulfite, sodium sulfite, and sulfur dioxide, have enjoyed widespread use as food and drug ingredients. The oral ingestion of these sulfiting agents is now known to trigger asthma in a small subset of the asthmatic population. The best evidence suggests that perhaps 150,000 to 200,000 individuals in the United States may be sulfite sensitive. Although the mechanism of sulfite-induced asthma remains unknown, several possibilities have been considered, including inhalation of sulfur dioxide (SO₂) while swallowing, an IgE-mediated reaction, and a deficiency of sulfite oxidase leading to impaired sulfite …

Clinical Use Of A Standard Kit-Preparation Of Radiolabeled Monoclonal Antibody 96.5 In The Diagnostic Imaging Of Metastatic Melanoma., Mansoor Saleh, D M. Miller, L Peterson, C D. Russell, M W. Unger

Haematology and Oncology, East Africa

We studied the efficiency of a standard-kit preparation using 1 mg 111In-labeled 96.5 monoclonal antibody in combination with 19 mg of unlabeled antibody in the diagnostic imaging of 27 patients with documented metastatic melanoma. Twenty-three of 26 patients (88%) demonstrated immunoscintigraphic localization of tumor. Of 104 metastatic sites previously documented by conventional studies, 62 (60%) were identified by immunoscintigraphy. A total of 77 sites demonstrated localization of radiolabeled antibody. Fifty-four (70%) corresponded to known sites of disease; eight sites (10%) were "discovered" by immunoscintigraphy and subsequently confirmed by conventional studies; 15 imaged sites (20%) could not be confirmed by conventional …

Ocular Irrigating Solutions: A Comparison Between Balanced Salt Solution And L-410 (Po-Eis), Philip C. Hessburg, Paul M. Johnston

Henry Ford Hospital Medical Journal

The ability of two ocular irrigating solutions to reduce postoperative corneal edema after intracapsular cataract extraction was compared using ultrasonic pachymetry. All patients had anterior chamber intraocular lenses implanted. The solutions were balanced salt solution and solution L-410 (PO-EIS), an eye irrigation solution containing dextran 40 and bicarbonate. Corneas irrigated with either solution showed no significant difference in postoperative edema. The use of L-410 (as an alternative to balanced salt solution) may not be necessary in intracapsular cataract extraction.

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1987), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1987 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• 60^th Anniversary Issue
• O. J. Snyder Medal Laureates
• PCOM Presidents
• PCOM Deans
• 1898-1913: Founders & Foundations
• 1914-1926: The Spring Garden Era
• 1927-1936: Development & Depression
• 1937-1946: The War Years
• 1947-1956: The Post-War Era
• 1957-1966: The Grandest Expansion
• 1967-1976: Progress & Exhilaration
• 1977-1987: Arrivals & New Departures
• On Campus: Faculty in Focus
• Class Acts
• Sun Coast Hospital Celebrates Its Founder & 30^th Anniversary
• In Memoriam
• Calendar

Insulin And Glucagon Responses To Dietary Protein In Diabetic And Nondiabetic Men, Monica L. Blomstedt

Loma Linda University Electronic Theses, Dissertations & Projects

Five men with non-insulin-dependent diabetes mellitus and fourteen nondiabetic men, were given test meals with soy protein, casein or additional carbohydrate in place of protein. Blood levels of insulin, glucagon, glucose and lipids were measured at fasting, one-half hour and two hours postprandial. To all meals, the nondiabetic subjects responded with a quick rise of the insulin level which decreased at two hours. In contrast, the diabetics showed a significantly lower insulin response at one-half hour (p < 0.05), but a tendency to higher levels at two hours. The same pattern was observed in the insulin to glucagon ratio. No significant difference between the meals was found in regard to insulin or glucagon responses, suggests that a sustained, although delayed postprandial insulin response, may be a precursor to the higher cholesterol and increased risk for cardiovascular disease among diabetics.

Department Of Radiology-Annual Report-July 1, 1986 To June 30, 1987, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1986 to June 30, 1987. Thomas Jefferson University Hospital, Philadelphia,Pennsylvania, United States. 106 pages.

Localization Of A Radiolabeled Monoclonal Antibody To Calcitonin In Rat Medullary Thyroid Carcinoma Allografts, Naguib A. Samaan, Kuo-Pao Yang

Henry Ford Hospital Medical Journal

A radiolabeled anticalcitonin monoclonal antibody (MoAb) was testedfor tumor-localizing capability in WAG/Rij rats allografted with cultured medullary thyroid carcinoma cells (line 44-2). 131I-labeled anticalcitonin IgG was taken up by the tumors in a time-dependent and dose-dependent manner. Tumor tissue uptake of the injected MoAb was 0.7 to 1.3%/g of tumor tissue when tested with a dose range of 40 lo 250 μg/kg of body weight. Distribution ratios of the radiolabeled MoAb were 1.2:1 for tumor-to-blood and 2-20:1 for tumor-to-organs. In rats injected with control IgG, disiribution ratios of radioactivity were 0.4:1 for tumor-to-blood, and 0.6-2:1 for tumor-to-organs. These results suggested …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1987), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1987 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Imperatives for Success
• Osteopathic's Surgicenter
• Tage N. Kvist, Ph.D.
• Research at OMCP
• The Changing Challenge of Student Recruitment
• On Campus
• PCOM's Rugby Triumph
• Class Acts
• In Memoriam
• Calendar

The Clinicians' Guide To Creutzfeldt-Jakob Disease, Thomas H. Swanson

Henry Ford Hospital Medical Journal

Creutzfeldt-Jakob disease, a transmissible, rapidly progressive dementia of unknown etiology, mimics Alzheimer's disease, presents in middle life, and affects many central nervous system structures. The disease progresses in three distinct stages, culminating in death. Its occurrence is sporadic and its distribution worldwide. Pathological changes are varied, but spongy degeneration of the neuropil is classic. Research on scrapie, the animal model of Creutzfeldt-Jakob disease, has demonstrated that this unconventional, slow disease is transmitted via a small (less than 50,000 mW) particle, which is composed principally of protein. How this infectious particle, variably named prion, virino, or slow virus, invokes disease or …