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Stereospecific Opiate Binding In Human Erythrocyte Membranes And Changes In Heroin Addicts, Leo G. Abood, Holly G. Atkinson, Mary Macneil

Publications and Research

Stereospecific opiate binding has been demonstrated in human erythrocyte membranes, having a Kd of 9-10(-9) M. In most respects the binding characteristics resemble those of synaptic membranes. These included the correlation of binding affinity and pharmacological potency of opiates; competition by naloxone; inhibition by Ca2+ and Na+; and sensitivity to phospholipases and trypsin. A comparison of stereospecific opiate binding in control human subjects and heroin addicts revealed a 43% increase in the addict group.

Ultrastructure And Chemical Composition Of Microconidial Walls Of Trichophyton Mentagrophytes, Christine Da-Ruh Wu

Dissertations

No abstract provided.

Patterns Of Fatty Acid Release From Endogenous Substrates By Human Platelet Homogenates And Membranes, A Derksen, P Cohen

Faculty, Staff and Students Publications

We describe a method for measuring the release of fatty acids from endogenous substrates of human platelet homogenates and membranes. The method depends on the availability of lipids whose fatty acids are odd-chained and therefore suitable as internal reference compounds that, at the time of lipid extraction, can be added to an incubation to permit subsequent quantification of the content of free fatty acids or fatty acids esterified to specific lipids. We found four types of lipolytic activities in human platelets. In homogenates at pH 4.0 a triglyceride lipase operated as shown by the synchrony of triglyceride degradation and release …

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

An Analysis Of Blood Cortisol Levels In Oral Surgery Patients Under Various Levels Of Intravenous Medication, Fred L. Bunch

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to objectively evaluate each pharmacological component of the Loma Linda intravenous sedation technique. The results were evaluated as a function of stress as measured by plasma cortisol levels.

The study was conducted on fifty patients in groups of ten. Blood samples were taken at set procedure intervals during dental extraction of third molar teeth. A component of the Loma Linda technique was deleted from each of the groups to ascertain its role in sedation and relief of stress.

Results show a trend toward reduction of plasma cortisol levels as the procedure progresses, indicating a measure of …

The Effect Of A Pufa Diet On Human Red Blood Cell Levels Of 2, 3-Dpg, Sandra A. Dassenko

Loma Linda University Electronic Theses, Dissertations & Projects

Fasting blood was collected at weekly intervals and the level of 2,3-DPG of the red blood cell was determined in 15 male subjects age 28 to 57 with serum cholesterol levels greater than 250 mg%. A lactovegetarian diet containing no cholesterol, a high level of dietary fiber and a P/S ratio of 4.0 was provided for 28 days.

During the course of the experimental period the 2,3-DPG increased by an average of 0.83> «moles/ml red blood cell which was highly significant (p^.001). This significant increase of 2,3-DPG which relates to an increased oxygen delivery capability of the red blood cells …

Bibliography Of Secondary Sources On The History Of Dermatology Ii. Obituaries And Biographies In English Before 1973, Lawrence Charles Parish, M.D., John Thorne Crissey, M.D., Jennifer L. Parish, M.D., Daniel H. Parish, J.D.

Department of Dermatology and Cutaneous Biology Faculty Papers

Bibliography of Secondary Sources on the History of Dermatology

II. Obituaries and Biographies in English before 1973

The Xyy Syndrome And The Judicial System, Paul Cheverie

North Carolina Central Law Review

No abstract provided.

Effect Of Speed Of Muscle Contraction On Strength Improvement, Terry Alan Dieckhoff

Masters Theses

No abstract provided.

Faculty Publications July 1971 - Dec 1972, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 437 publications.

Value Of Oxygen With Innovar And Methohexital For Outpatient Oral Surgery, Andrew D. Harsany

Loma Linda University Electronic Theses, Dissertations & Projects

This paper demonstrates the value of oxygen in maintaining arterial blood gas in an adequate range during outpatient oral surgery. Dental extractions were completed on ten patients under an anesthetic technique utilizing Innovar and methohexital with supplemental nasal oxygen. Blood gas samples were drawn at five stages during the procedure.

The mean of the PaO₂ samples drawn with the patient at the point of deepest sedation was approximately three times the normal value.

Oxygen for pulmonary ventilation provides a reservoir in the lungs, saturation of hemoglobin, and increased oxygen in the plasma which provides a margin of safety if …

The Effect Of Glucose On The Food Intake Of Goldthioglucose Injected Mice, Janet Lahti

Dissertations and Theses

Jean Mayer has postulated the presence of glucoreceptors located primarily in the ventromedial hypothalamic nuclei of the brain which are activated by glucose in the measure that they utilize it. According to Mayer, hunger occurs when glucose is not available for metabolic purposes and satiation supervenes when glucose is made available. Control of this mechanism rests with the glucoreceptors. These receptors are believed to be destroyed when an injection of the compound goldthioglucose is given to mice. These animals subsequently become obese and are found to have gold deposits and lesions in the ventromedial area and also in other parts …

Mathematical Model Of Placental Oxygen And Carbon Dioxide Exchange, Ester P. Hill

Loma Linda University Electronic Theses, Dissertations & Projects

This model of placental CO₂ and O₂ exchange calculates the time course of changes in P_^CO2, [HCO₃^-], and [H⁺] in each of four "compartments" of placental exchange vessels: maternal erythrocytes, maternal plasma, fetal plasma and fetal erythrocytes. The changes in hemoglobin-bound CO₂ (carbamate) and oxyhemoglobin contents within the erythrocytes are also calculated, permitting consideration of the Haldane and Bohr effects. Equations were written to represent one-dimensional steady state CO₂ and O₂ diffusion between concurrent maternal and fetal capillaries and the subsequent hydration, carbamino and oxyhemoglobin reactions. The equations …

Effect Of Lateral Positioning On Central Venous Pressure, Romelda C. Jereos

Loma Linda University Electronic Theses, Dissertations & Projects

This experimental study was conducted to investigate the effects of lateral positioning on central venous pressure. It was hypothesized that lateral positioning would not significantly change the central venous pressure so long as the subjects were placed on the same horizontal plane for both supine and lateral measurements. It was also hypothesized that the length of time spent in the lateral position would not alter the pressure.

It is recognized that several factors do indeed play important roles in the maintenance of central venous pressure. The effect of one particular influencing factor, gravity, was central to this study. The difference …

An Anesthetic Technique Utilizing Innovar, Fentanyl, And Methohexital Sodium For Outpatient Oral Surgery, Fredric D. Haerich

Loma Linda University Electronic Theses, Dissertations & Projects

A study of 800 patients ranging in age from seven to one hundred years was conducted in the development of an anesthetic technique which combines the desirable qualities of a neuroleptic agent with the requirements of an outpatient oral surgical anesthetic. These requirements included rapidity of onset, effectiveness of action, ease of controlling duration, and rapid postoperative recovery.

Patients who were cleared medically for outpatient procedures were given Innovar 1.5 cc/150 lb of body weight, atropine 0.4 mg, and fentanyl 1.0 cc/150 lb of body weight as an initial dose within 30-45 seconds in a D5W drip by means of …

A Follow-Up Study Of Patients With Chronic Obstructive Lung Disease And Their Practice Of The Breathing Pattern, A. Theodora Djagia

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this descriptive survey was to do a follow-up study on patients with COPD to find out to what extent these patients have followed instruction to continue exercising the abdominal and diaphragmatic muscles, with the utilization of a breathing pattern. Literature was reviewed which revealed contradictory findings in regard to the physiological benefits of the use of the breathing pattern. Nine patients met the criteria and signed a consent sheet to be visited in their homes. An Observation Data Sheet and Interview Guide were the tools used to collect data. A point system was constructed and used with …

An Investigation Of Cerebrovascular Factors In Head Injury: A Multifaceted Multidisciplinary Approach. Nih Proposal For A Head Injury Center At Loma Linda University, George M. Austin

The Dr. George M. Austin Neurology Research Collection

An Investigation of Cerebrovascular Factors in Head Injury: A Multifaceted Multidisciplinary Approach. NIH proposal for a Head Injury Center at Loma Linda University. George Austin.

1. Typewritten letter. G.A. to Matilda Solowey, Extra Mural Programs, National Institutes of Health, Washington D.C., May 30, 1970. 1 pg.
2. “Head Injury Center; Supplement to: An Investigation of Cerebrovascular Factors in Head Injury: A Multifaceted Multidisciplinary Approach,” 14 pg.
3. “Specialized Clinical Research Head Injury Center, Loma Linda University School of Medicine, Loma Linda, California, George M. Austin, M.D., Professor of Neurosurgery, Additional Supporting Bibliography,” 1 p. Contains entries 90-97.
4. “Cerebral Blood Flow Changes in Vasospasm …

A Study To Demonstrate The Immediate Destination Of An Embolus Formed In The Lumen Of A Peripheral Venous Catheter, Rosemarie Morikone Emori

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to show the immediate destination of an embolus formed in the lumen of an intravenous catheter placed in a peripheral vessel. The hypothesis stated that clots injected into a peripheral vessel will lodge in the lungs. A subhypothesis was that the clot may lodge anywhere along the circulatory pathway.

Indications of need for the study as shown by the review of literature were the following: (1) the complications resulting from the frequent use of intravenous polyethylene catheters, (2) experimental studies that showed that clots were formed around intravenous catheters, (3) the evidence that intravenous catheters predispose …

Some Aspects Of Carbohydrate Metabolism In The Cercariae Of Schistosoma Mansoni Sambon, 1907, A. Eugene Dunham Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

Cercariac of Schistosoma mansoni were studied for glycogen utilization, uptake of glucose from solution, lactic acid production, and respiration.

Using the anthrone method of determination of carbohydrate, the amount of glycogen used by a single cercaria in 4 hours is determined as 43.2 x 10^-4 μg ± 6.6 x 10^-4 μg.

Glucose was not observed to have been used from solution under the conditions of the experiment, even in the presence of trehalose. The determinations were made by the Glucostat method.

After deproteinization and desugarization, aliquots of supernatant from cercarial suspensions were analyzed for lactic acid using p-phenylphenol …

The Esophageal Propulsive Force: Esophageal Response To Acute Obstruction, Daniel H. Winship, F. Frank Zboralske

Biomedical Sciences Faculty Research and Publications

The response of the normal human esophagus to an obstructing intraluminal bolus was investigated and compared to the response evoked by transient intraluminal distention. A balloon, immobilized within the esophagus by external attachment to a force transducer, was inflated with from 3 to 25 ml of air for from 3 to 210 sec. Pressure phenomena occurring in the esophagus were simultaneously recorded from the body of the esophagus above and below the balloon.

Transient distention (5 sec or less) with small volumes (5 ml or less) often evoked a secondary peristaltic wave in the esophagus distal to the balloon, but …

The Effects Of Particular Sounds On Certain Indices Of Cardio-Pulmonary Functions, Harold F. Googe, Jane Mundin

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to identify the effects of particular sounds upon certain indices of cardio-pulmonary function and the degree and pattern of changes which occurred in the indices. The specific physiological parameters chosen to be monitored were heart rate, respiratory rate, mean tidal volume, instantaneous minute volume, and oxygen consumption. The hypothesis was that particular sounds will cause changes in certain indices of cardio-pulmonary functions. This was a controlled experiment, in which nine healthy males and nine healthy females, of a denominational, medically oriented University listened to a specially constructed tape of background music interspersed with an …

Studies Of The Mechanism By Which Chronic Metabolic Acidosis Augments Urinary Calcium Excretion In Man, Jacob Lemann Jr., John R. Litzow, Edward J. Lennon

Biomedical Sciences Faculty Research and Publications

We carried out clearance studies in nine healthy adults and four patients with hypoparathyroidism before and after inducing stable metabolic acidosis with either NH₄Cl or acetazolamide. Clearances were repeated in seven normal subjects and three of the patients 3 days after stopping these agents.

During acidosis in the normal subjects, serum ultrafilterable calcium concentration rose significantly, but inulin clearance fell to a greater extent, so that the calculated filtered load of calcium fell significantly. Despite this, urinary calcium excretion rose. Urinary calcium excretion remained elevated in the recovery studies when the serum ultrafilterable calcium concentration and filtered load …

The Effect Of Treatment Of Acidosis On Calcium Balance In Patients With Chronic Azotemic Renal Disease, John R. Litzow, Jacob Lemann Jr., Edward J. Lennon

Biomedical Sciences Faculty Research and Publications

Small but statistically significant negative calcium balances were found in each of eight studies in seven patients with chronic azotemic renal disease when stable metabolic acidosis was present. Only small quantities of calcium were excreted in the urine, but fecal calcium excretion equaled or exceeded dietary intake. Complete and continuous correction of acidosis by NaHCO₃ therapy reduced both urinary and fecal calcium excretion and produced a daily calcium balance indistinguishable from zero.

Apparent acid retention was found throughout the studies during acidosis, despite no further reduction of the serum bicarbonate concentration. The negative calcium balances that accompanied acid retention …

Scientific Approach To 4-H Food Projects, Grace Brill

Journal of the Minnesota Academy of Science

The scientific approach to 4-H food projects resulted from the stress on science from federal extension personnel of the U.S. Department of Agriculture, and from surveys and consultations with representatives of the National Science Foundation. The result has been six bulletins prepared by the extension nutritionists of the University of Minnesota for the approximately 24,000 4-H members, aged 9 to 19, enrolled in 4-H food projects in Minnesota. The scientific approach has, consequently, added the question of "why" to the traditional 4-H approach of "how-to-do-it."

Pneumonia Due To Mycoplasma In Gnotobiotic Mice: Ii. Localization Of Mycoplasma Pulmonis In The Lungs Of Infected Gnotobiotic Mice By Electron Microscopy, Avrum B. Organick, Kenneth A. Siegesmund, Irving I. Lutsky

Biomedical Sciences Faculty Research and Publications

Organick, Avrum B. (Marquette University School of Medicine, Milwaukee, Wis.), Kenneth A. Siegesmund, and Irving I. Lutsky. Pneumonia due to mycoplasma in gnotobiotic mice. II. Localization of Mycoplasma pulmonis in the lungs of infected gnotobiotic mice by electron microscopy. J. Bacteriol. 92:1164–1176. 1966.—Lesions in lungs of gnotobiotic mice inoculated intranasally with Mycoplasma pulmonis were examined by electron microscopy after osmic acid fixation. At 1 week after infection, mycoplasma cells were found in large numbers in the bronchi at the surface of bronchial epithelial cells and, in smaller numbers, in the alveoli where active phagocytosis by polymorphonuclear leukocytes (PMN) occurred. …

Poison Plants In The Garden, T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

SOME 18 commonly grown garden plants are known to be toxic and many local home gardens have five or six of them.

Several other species can cause skin ailments.

Responses Of The Normal Human To Infusions Of Plasma From Patients With Graves' Disease, Claude D. Arnaud, Hans A. Kneubuhler, Virginia L. Seiling, Bruce K. Wightman, Norman H. Engbring

Biomedical Sciences Faculty Research and Publications

No abstract provided.

Sex And The Transurethral Prostatectomy, Edward T. Moon

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this research was to find out what effects the TURP has on ejaculatory ability, frequency of coitus and the emission of seminal fluid. The sample consisted of 50 men, age 46-65, who were married, and had no cancer or other possible physical causes for impotence. Each man was personally interviewed.

Forty-six patients (92 percent) were able to ejaculate. A decrease in the frequency of coitus was reported by 40 per cent of the men. A normal ejaculation of seminal fluid was experienced by thirteen (26 percent) of the men. Considering all the changes in the sexual function …

The Net Balance Of Acid In Subjects Given Large Loads Of Acid Or Alkali, Jacob Lemann Jr., Edward J. Lennon, A. David Goodman, John R. Litzow, Arnold S. Relman

Biomedical Sciences Faculty Research and Publications

No abstract provided.

Production, Excretion, And Net Balance Of Fixed Acid In Patients With Renal Acidosis, A. David Goodman, Jacob Lemann Jr., Edward J. Lennon, Arnold S. Relman

Biomedical Sciences Faculty Research and Publications

No abstract provided.