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Lifeline - City Of Faith Newsletter (Dec, 1983), Holy Spirit Research Center Oru Library

City of Faith

Lifeline vol 2, no 2 (Oct 1983)

Lifeline is the newsletter for the employees and staff of the City of Faith Medical and Research Center. This edition includes the following articles:

• "New Pediatrics, Family Medicine Units Open"
• "COF Comes Through - The United Way"
• "Grounds Crew Makes Good First Impression"
• "Speech Pathology Proving to be Popular Addition"
• "Welcome New Employees and Staff"

1983 Fall No. 4, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medical Alumni Quarterly Number 4 Fall 1983 was edited by Richard M. Paddison, MD, and published by the LSU School of Medicine Office of Alumni Affairs.

This issue consists of 16 pages.

The Effects Of Triethyltin Bromide On Red Cell And Brain Cyclic Amp-Dependent Protein Kinases, Kevin R. Siebenlist, Fumito Taketa

Biomedical Sciences Faculty Research and Publications

Triethyltin bromide activates the cyclic AMP-dependent protein kinases of human red cell membranes and of bovine brain. Additions of 25-500 microM triethyltin to red cell ghosts resulted in enhanced phosphorylation of ghost proteins. When added to partially purified cyclic AMP-dependent protein kinases from red cell ghosts or bovine brain, stimulation of the phosphorylation of calf thymus histone was observed. The enhancement of kinase activity was due to release of catalytic subunits from the intact protein kinase. Brief exposure of the partially purified enzymes to triethyltin, followed by DE52 chromatography, resulted in elution profiles for regulatory and catalytic subunits that were …

Identification Of Four Complementary Rna Species In Akabane Virus-Infected Cells, Asit K. Pattnaik, G. Abraham

School of Veterinary and Biomedical Sciences: Faculty Publications

The analysis of RNA extracted from purified Akabane virus demonstrated the presence of three size classes of single-stranded RNAs with sedimentation coefficients of 31S (large, L), 26S (medium, M), and 13S (small, S). Molecular weights of these RNA species were estimated to be 2.15 x 10⁶,1.5 X 10⁶, and 0.48 x 10⁶ for the L, M, and S RNAs, respectively. Hybridization analysis involving viral genomic RNA and RNA from virus-infected cells resulted in the identification of four virus-specific cRNA species in infected cells. These cRNAs were found to be nonpolyadenylated by their inability to bind …

Lifeline - City Of Faith Newsletter (Jan, 1983)), Holy Spirit Research Center Oru Library

City of Faith

Lifeline vol 1, no 3 (Jan, 1983)

Lifeline is the newsletter for the employees and staff of the City of Faith Medical and Research Center. This edition includes the following articles:

• "1983 Declared the Year of Research"
• "Quick Growth by a Great Staff"
• "Lay Prayer Partners Recognized"
• "Welcome New Nurses"
• "Welcome New Employees and Staff"
• "Departments Celebrate the Season"

Pathology, Jean Holland Saumur

UND Departmental Histories

This departmental history was written on the occasion of the UND Centennial in 1983.

Physiology And Pharmacology: 1905-1977; Physiology: 1977-1983, Helge Ellis Ederstrom, Stanley J. Brumleve

UND Departmental Histories

This departmental history was written on the occasion of the UND Centennial in 1983.

Lifeline - City Of Faith Newsletter (Oct, 1982), Holy Spirit Research Center Oru Library

City of Faith

Lifeline 1, vol 1 (Oct 1982)

Lifeline is the newsletter for the employees and staff of the City of Faith Medical and Research Center. This edition includes the following articles:

• "Major COF Marketing Thrust Begins"
• "The State of Our Institution" by James Winslow, M.D.
• "Hospital Receives Accreditation"
• "Optical Clinic Opens"
• "Fitness Center Goes Public"
• 'New Physicians"
• "New Nurses"
• "Welcome New Residents"
• "Hinshaw Named Medical School Dean"
• "Medical School Departments Move to City of Faith"
• "City of Faith to Pioneer Pre-paid Health Care in Tulsa"

Effects Of The Serotonin Depletor Parachlorophenylalanine Upon Shock-Induced Aggression And Pressing Responses In Rats, Robert G. Sewell

Masters Theses

The literature concerning the effects of d, l-parachlorophenylalanine (PCPA) upon shock-induced aggression (SIA) is reviewed and found to be inconsistent. PCPA, a known serotonin depletor, has behavioral effects in a variety of other procedures which collectively suggest that PCPA should produce SIA enhancement. The present study was designed to analyze PCPA (300 mg/kg) effects upon SIA in rats restrained spatially close to an inanimate target and panel operandum. The results showed marked increases in both aggressive biting and panel pressing for several days following each PCPA treatment for each subject tested. These data were interpreted to indicate that serotonin depletion …

Discordant Expression Of Fetal Hydantoin Syndrome In Heteropaternal Dizygotic Twins, Mary C. Phelan , B.S., John M. Pellock , M.D., Walter E. Nance , M.D., Ph.D.

Human and Molecular Genetics Publications

No abstract provided.

The Relationship Between Socioeconomic Factors, Attitudes, And The Frequency Of Pap Smears Of Female Patients In A Rural Health Care Center, Kathy Ann Barnes

MUSC Theses and Dissertations

Fifty-seven women over the age of 16, seeking care at a rural health center, completed questionnaires concerning demographic factors and health beliefs and attitudes. Correlation coefficients and Z scores were computed for the variables. There was significant positive correlation in both demographic and health belief and attitude areas. Discussed also are factors possibly contributing to the test results, as well as alternative research models.

T Cell Growth Factor Receptors. Quantitation, Specificity, And Biological Relevance, Richard J. Robb, Allen Munck, Kendall A. Smith

Dartmouth Scholarship

To examine directly the hypothesis that T cell growth factor (TCGF) interacts with target cells in a fashion similar to polypeptide hormones, the binding of radiolabeled TCGF to various cell populations was investigated. The results indicate that TCGF interacts with activated T cells via a receptor through which it initiates the T cell proliferative response. Internally radiolabeled TCGF, prepared from a human T leukemia cell line and purified by gel filtration and isoelectric focusing, retained biological activity and was uniform with respect to size and charge. Binding of radiolabeled TCGF to TCGF-dependent cytolytic T cells occurred rapidly (within 15 rain …

Isolation Of Plasma Membrane From Human Neutrophils And Determination Of Cytochrome B And Quinone Content, Edward P. Sloan, Dana R. Crawford, Donald L. Schneider

Dartmouth Scholarship

Analyses of plasma membrane and other subcellular fractions indicate that the primary location of cytochrome b in human neutrophils is not the plasma membrane. The procedure developed for the purification of plasma membrane from fresh human neutrophils yielded a 14-fold enrichment in the marker enzyme 5'-nucleotidase and a 10-fold enrichment in ouabain-sensitive ATPase. On sucrose density gradients, the peak density of 5'-nucleotidase activity was 1.12 g/ml, and was shifted after digitonin addition to 1.15 g/ml. Protein in the plasma membrane equalled approximately 8 percent of the whole cell protein. A b-type cytochrome was found to be present in the plasma …

A Field Investigation Of Meiofaunal Dispersal: Tidal Resuspension And Implications, Susan S. Bell, K. M. Sherman

Integrative Biology Faculty and Staff Publications

Presence of meiofauna in resuspended sediments was investigated in a tidal creek system employing a specially designed core sampler and quick freezing techniques. Forty core samples were taken during 4 successive ebb tides to determine the distribution of meiofauna in (a) overlying water; (b) resuspended sediment; and (c) undisturbed sediment fractions of each sample. Our experiments demonstrate that 13-44 % of the meiobenthic copepod subcommunity was present in overlying and resuspended sediment fractions, while only a small percentage of nematodes was found simultaneously in these layers. We suggest that selected meiofauna may disperse through tidally coupled mechanisms and that such …

Insulin Degradation By Adipose Tissue. Studies At Several Levels Of Cellular Organization, Barry J. Goldstein, James N. Livingston

Department of Medicine Faculty Papers

A systematic study of the degradation of physiological concentrations of ¹²⁵I-labelled insulin was performed in intact fat-pads, isolated adipocytes and subcellular fractions of isolated adipocytes. The findings indicate that insulin is rapidly degraded to low-molecular-weight peptides and/or amino acids by the intact tissue and isolated cells. Of the total insulin-degradation products present after incubation with an intact fat-pad, 94% is recovered in the medium, indicating that these products are not retained by the cells or tissue. The plasma membranes do not degrade insulin significantly in the absence of reduced glutathione, and over 99% of the cellular degradative capacity is …

Population-Based Measurement Of Hospital Use In Maine Areas, 1976, David Soule

Maine Collection

Population-Based Measurement of Hospital Use in Maine Areas, 1976

Prepared by: David Soule, Data Analyst, Maine Health Data Service, Project Director - Maine Hospital Statistics Analysis Project, December, 1979.

With complementary funding from: Cooperative Health Statistics System, National Center for Health Statistics, Contract No. (HRA) 230-76-0298.

Bureau of Health Planning and Development, Maine Department of Human Services.

Maine Health Data Service. Blue Cross and Blue Shield of Maine.

Contents; Acknowledgements / Introduction / Data Sources and Definitions / Findings / References / Appendix Tables

A Scale For Assessing The Severity Of Diseases And Adverse Drug Reactions: Application To Drug Benefit And Risk, Ronald J. Tallarida, Rodney B. Murray, Carl Eiben

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Physicians were interviewed to assess their willingness to risk adverse drug reactions among patients. These untoward reactions were ranked according to severity and weighted against the primary illness being treated. A specially designed questionnaire in the form of a matrix was used. Severity was divided into seven classes denoted by progressively increasing numerical scores, W₁ to W₇, whose values could be calculated from analysis of the completed questionnaires. The questionnaires presented several cases, in each of which an illness of specified severity was to be treated with a drug whose untoward reactions differ in severity from that …

Interplanetary Magnetic Field Sector Polarity And Neuropsychiatric Adaption: A Reanalysis, Hans W. Wendt

Journal of the Minnesota Academy of Science

Recent Russian studies reported associations between adaptation syndromes and (solar activity-related) interplanetary magnetic field (IMF) sector polarity. Certain ambiguities in the original work suggested some reanalyses, based on the graphs and data made available. Syndrome status exhibited a biphasic (semi annual) trend. It also correlated with specific geomagnetic changes during magnetic storms and possibly after sudden impulses. Moreover, lag effects and higher order interactions were noted among all parameters investigated. The restudy tends to support some of the original findings but also suggests new conclusions regarding potential relationships between geophysical/solar and psychophysiological processes.

Role Of A Nonimmunoglobulin Cell Surface Determinant In The Activation Of B Lymphocytes By Thymus-Independent Antigens*, Subbarao Bondada, Donald E. Mosier, Aftab Ahmed, James J. Mond, Irwin Scher, William E. Paul

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Lyb 5 is a B-cell alloantigen which is expressed on 50-60% of B cells. It was defined originally on the basis of cytotoxicity. We have described a new reactivity within the anti-Lyb 5 serum on the basis of selective inhibition of antibody responses in vitro by this antiserum in the absence of complement. This inhibitory activity of anti-Lyb 5.1 serum appears to be due to recognition of antigenic determinants different from the prototype antigens detected in the cytotoxicity assay. Anti-Lyb 5 serum incorporated into spleen cell cultures selectively inhibits antibody responses to a class of thymus-independent antigens (TI-2) previously characterized …

Tritium (3h) Radiolabeling Of Protein A And Antibody To High Specific Activity: Application To Cell Surface Antigen Radioimmunoassays, Ronald L. Wilder, Catherine C. Yuen, Subbarao Bondada, Virgil L. Woods, Cornelius B. Alexander, Rose G. Mage

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Staphylococcal protein A and several different immunoglobulins have been radio-labeled to high specific activities (> 106 cpm/pg) by reductive methylation with tritiated (3H) sodium borohydride. The proteins retain excellent functional and antigenic properties. The utility of these reagents in a variety of assays for cell surface antigens is illustrated. The results indicate that this radiolabeling procedure may become the method of choice for many cell surface and solution immunoassays.

Computer Modeling Of Cardiac Electrical Activity By Polarcardiogram Patterns, Daniel K. Berry

Loma Linda University Electronic Theses, Dissertations & Projects

The objective of this thesis is to provide for the cardiologist polarcardiograms and additional diagnostic criteria which will enable him to diagnose heart disease more easily. Other contributions are those of: (a) providing a system of data acquisition and (b) analyzing Dr. Gordon Dower’s criteria for myocardial infarction using the programs provided in this thesis.

The problem inherent in the reading of a polarcardiogram is the identification of the "loop" patterns with the associated heart disease. This can be accomplished by reading and interpreting both vectorcardiograms and electrocardiograms as well as angiograms, then relating the interpretation to the polarcardiogram patterns. …

Systemic Membrane Defect In The Proximal Muscular Dystrophies, Nathan A. Pickard , Ph.D., Hanns-Dieter Gruemer , M.D., Harland L. Verrill , Ph.D., Edward R. Isaacs , M.D., Meinhard Robinow , M.D., Walter E. Nance , M.D., Ph.D., Edwin C. Myers , M.D., Barbara Goldsmith , B.S.

Human and Molecular Genetics Publications

Abstract

We studied lymphocyte capping in 61 patients with Duchenne, Becker, limb-girdle, facioscapulohumeral and congenital muscular dystrophies. All showed a markedly diminished percentage of capped cells when compared with 86 normal controls, providing support for previous evidence that an alteration in membrane fluidity may be a common pathogenic feature in several genetically distinct forms of proximal muscular dystrophy.

Heterozygous carriers of Duchenne muscular dystrophy showed diminished capping that was indistinguishable from that of afflicted males and was often present even when serum enzyme levels were normal. Studies in 25 families with 16 suspected sporadic cases indicated that no more than …

Taste-Masking: Function Of Exaggerated Prandial Drinking In Desalivate Mice, Richard C. Lewis

Journal of the Arkansas Academy of Science

Taste thresholds for the bitter compound sucrose octaacetate (SOA) were elevated by desalivation in mice. Thresholds were determined for control and experimental animals both before and after ligation of all salivary ducts. There was a significant increase in SOA thresholds in the desalivate mice, and the pre- to post-operative differences in threshold between the control and experimental groups were significant. The altered response to SOA by desalivate mice is shown to be due to the assumption of a prandial pattern of drinking as a result of desalivation. This conclusion is based on experiments with wet mash which failed to show …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Administration Documents

Papers representative of the variety of scholarly research conducted at WKU.

• Adams, Kathy. The Appalachian Language
• Barnett, Philip. A Study of Deviant Behavior of XYY Individuals in Regard to Environment and Genotype
• Bell, Brooks. Loving, Loyal Linda Loman: An Interpretive Note
• Danhauer, Janice. Motivating Workers Through Job Design
• Davis, Barbara. The Transformation of a Man into a Man of Understanding in Murinbata Society
• Davis, Diane. The Argot of the Homosexual
• Jewell, Teresa. The Life Story of the Hero of World War I - Sergeant Alvin C. York
• Lanham, Wayne. Das Knarrenschiff and a Ship of Fools: A Study in Influence …

1977 Vol. 3 No. 2, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medicinews Volume 3 Number 2 was edited and published by the staff of the School of Medicine Editorial Office.

This issue consists of 8 pages. The publication date is September 1977.

The Pi System Of Alpha-L-Protease Inhibitor (Alpha-L-Antitrypsin) Biochemical Immunological And Genetic Studies In Health And Disease, Philippe Arnaud

MUSC Theses and Dissertations

The results of our personal studies of alpha-l-protease inhibitor (APi, formerly termed alpha-l-antitrypsin), the major inhibitor of protease in extracellular fluids, are presented in this dissertation. In the first chapter, we describe techniques used for APi quantitation and determination of Pi phenotypes. After a brief review of the available techniques, we report several improvements on our original technique of Pi phenotyping using thin-layer isoelectric focusing. Particular attention is given to biochemical and immunological methods for verification of the results obtained by isoelectric focusing. Three complementary techniques are reported: protease probe, crossed immunoelectrophoresis, and print immunofixation. Analysis of the results from …

Uptake Of Branched-Chain Alpha-Keto Acids In Bacillus Subtilis, Barry J. Goldstein, Stanley A. Zahler

Department of Medicine Faculty Papers

Bacillus subtilis has a constitutive system for the uptake of alpha-keto-beta-methylvalerate, alpha-ketoisovalerate, and (probably) alpha-ketoisocaproate. A mutation, kauA1, which blocks the uptake of alpha-keto-beta-methylvalerate and alpha-ketoisovalerate, is located between metB and citK on the B. subtilis chromosome.

Chemicals And Food: An Account About Additives, Wayland E. Noland

Journal of the Minnesota Academy of Science

Food additives are listed by functional category and discussed in terms of the scale of their use and relative risks in terms of long-term human toxicity. The greatest risks appear to lie with the antimicrobial preservative agents, and food colors (which serve only a cosmetic purpose); these and the synthetic sweeteners are discussed in relatively greater detail.

Chlorofluorocarbon Effects On Cardiac, Pulmonary, And Respiratory Patients, Mildred E. Olson

Journal of the Minnesota Academy of Science

Research results from studies of the physiological effects of aerosal propellants on animals and people are summarized. The papers selected for this summary were published between 1968 and 1975. Effects of the 15 chlorofluorocarbons used as propellants have been recorded on the cardiac, pulmonary and respiratory functions of a number of animal species as well as man. The fifteen propellants have been classified into four groups on the basis of their degree of toxicity. Fluorocarbon 11, the most frequently used propellant, is in group 1, the most toxic. The relative toxicity of each of the 14 other propellants compared with …

Measurement Of Permeability Of The Cell Membrane To Water, Richard Moore, Frederick Thornburgh, Donggyu Jin

Journal of the Minnesota Academy of Science

The water permeability was measured for blood cells from normal subjects and for blood cells from patients with leukemia. The method of measurement of the kinetics of water influx employed a stopped flow apparatus. The method of calculation of results was based on irreversible thermodynamics. The measurements and calculations were both performed with the assistance of a computer. The water permeability of the leukemic cells was decreased from normal, and the values were more variable than normal. Leukemia changes the structure of the cell membrane.