Digital Commons Network^™

The Relationship Of Alcohol Consumption In Rats To Morphine And Codeine Intake And The Metabolism Of Dopamine, Hsiu Fen Liu

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of morphine and codeine free-choice alcohol consumption in male Sprague-Dawley rats were studied. Intakes of a 10% alcohol solution in milliliters per 100 gm. of body weight were on recorded weekly. No difference was found in the alcohol intake of rats given either a morphine-supplemented diet (0.01% of the diet) or daily injection of morphine sulfate (2 mg./kg.); however, there was a significant lower intake of water (p < .05) in those rats fed the diet with morphine. Total fluid consumption of both groups given the morphine-supplemented diet and daily injection of morphine sulfate was decreased (p < .05). It was found that morphine did not affect the percentage of total fluid consumed as alcohol or the weight gain.

Two levels of codeine phosphate (10 mg./kg. and 20 mg./kg.) were injected subcutaneously into rats twice a day. It was observed that the codeine significantly decreased alcohol intake in rats …

The Effect Of Diet On Neutrophilic Phagocytosis, Linda L. Hoover

Loma Linda University Electronic Theses, Dissertations & Projects

Two series of experiments were conducted in order to determine the effects of diet on neutrophilic phagocytosis. The first series was designed to determine the effects of varying amounts of oral glucose on phagocytosis. Blood samples from 6 to 8 subjects were drawn at fasting, and at various time periods following ingestion of 12.5, 25, 50, 75, and 100 grams of glucose. In the second series of experiments, blood samples were taken from 11 subjects after an overnight fast and 2 hours following ingestion of one of 4 different liquid diets, which included the following: the meal (I), consisting of …

The Synthesis Of Active Site Directed Inhibitors For The Lac Permease Of Escherichia Coli, Mahmoud Ahmed

Theses and Dissertations (ETD)

No abstract provided.

Acid-Base Disorders: Evaluation And Instruction By Minicomputer, Deborah Likins Atkinson

MUSC Theses and Dissertations

A computerized system for instruction and diagnosis of clinical electrolyte and acid-base disorders has been implemented on a PDP-8/e minicomputer at the Medical University of South Carolina. The program is designed for use by persons at various stages of medical training: student, house staff, and clinician. This system not only aids the physician in making his diagnosis, but also serves as a means of educational instruction in acid-base physiology for the student. A patient file has been established in conjunction with the program. The file enables a physician to follow a patient's course over time. Several auxiliary computer programs have …

Chlorophyll Levels And Leaf Chlorplast Ultrastructure As Ecotypic Characters In Xanthium Strumarium L., Farag Abdulrahman

Masters Theses & Specialist Projects

The major objective of the work was to clarify some of the adaptive mechanisms that a common widespread species would show as a possible requirement for survival in its natural habitats. Analysis of various populations of Xanthium (cocklebur) indicated differences in chlorophyll levels and leaf chloroplasts ultrastructure between populations. The study also revealed some insight into intrapopulational variation in dark requirements for flowering of selected populations. In addition, caloric values of dried leaf material of cocklebur were analyzed for interpopulational differences. It was evident that higher chlorophyll levels are correlated with increase in latitude of origin and a corresponding decrease …

The Catabolism Of Thiamine By Phycomyces Blakesleeanus, Cheryl Lowe

Masters Theses & Specialist Projects

none

Seasonal And Spatial Distribution Of The Plankton Of Barren Lake, Kentucky, With Special Reference To The Phytoplankton Community, John Wright

Masters Theses & Specialist Projects

A study of the seasonal and spatial distribution of phytoplankters in relation to physio-chemical parameters and discharge regime was conducted in Barren Lake, Kentucky, a flood control reservoir with a dam equipped with a multilevel outlet, from February, 1970, through January, 1971. Paired samples were collected every two weeks from April through October and every three weeks from November through March. Samples were obtained from eight depths in the main pool area of the reservoir and from the tailwater. Reservoir discharge was primarily from the upper 3 m from April through September. At other times, discharge incorporated lower levels to …

Evidence For Bone Marrow Cell Attrition As A Mechanism For Granulocyte Regulation In The Canine, Vincent Dee Smith

Theses and Dissertations (ETD)

No abstract provided.

Partial Purification And Properties Of Nicotinamide Adenine Dinucleotide Phosphate-Specific Isocitrate Dehydorgenase Of Phycomyces Blakesleeanus, Adrienne Shanler

Masters Theses & Specialist Projects

none

The Effect Of Glucose On The Food Intake Of Goldthioglucose Injected Mice, Janet Lahti

Dissertations and Theses

Jean Mayer has postulated the presence of glucoreceptors located primarily in the ventromedial hypothalamic nuclei of the brain which are activated by glucose in the measure that they utilize it. According to Mayer, hunger occurs when glucose is not available for metabolic purposes and satiation supervenes when glucose is made available. Control of this mechanism rests with the glucoreceptors. These receptors are believed to be destroyed when an injection of the compound goldthioglucose is given to mice. These animals subsequently become obese and are found to have gold deposits and lesions in the ventromedial area and also in other parts …

Mathematical Model Of Placental Oxygen And Carbon Dioxide Exchange, Ester P. Hill

Loma Linda University Electronic Theses, Dissertations & Projects

This model of placental CO₂ and O₂ exchange calculates the time course of changes in P_^CO2, [HCO₃^-], and [H⁺] in each of four "compartments" of placental exchange vessels: maternal erythrocytes, maternal plasma, fetal plasma and fetal erythrocytes. The changes in hemoglobin-bound CO₂ (carbamate) and oxyhemoglobin contents within the erythrocytes are also calculated, permitting consideration of the Haldane and Bohr effects. Equations were written to represent one-dimensional steady state CO₂ and O₂ diffusion between concurrent maternal and fetal capillaries and the subsequent hydration, carbamino and oxyhemoglobin reactions. The equations …

Cardioregulatory Role Of The Abdominal Ganglion Of Aplysia Californica, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.

The principal results are listed below.

1. Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for …

Faculty Publications July 1969 - June 1970, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 164 publications.

The Development Of Electrophysiological Techniques Allowing "In Situ" Measurement Of Electrical Changes Within Smooth Muscle Cells Of Mesenteric Micro-Vessels, William J. Willems

Master's Essays (1922 - )

The primary objective or this study is essentially to acquire further knowledge of the factors involved in the nervous and humoral control of vascular smooth muscle tone. The relative importance of the nervous and endogenous vasotropic humoral control or vasomotor tone under normal conditions as well as under conditions or hypotension can be evaluated, at least in part, by observing the electrical activity occurring in single vascular smooth muscle cells of the mesenteric microcirculation. This thesis describes: 1) the development of electrophysiological methods for the measurement of such activity in ''in situ" micro-vessels with circulation and innervation intact, and 2) …

A Study To Demonstrate The Immediate Destination Of An Embolus Formed In The Lumen Of A Peripheral Venous Catheter, Rosemarie Morikone Emori

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to show the immediate destination of an embolus formed in the lumen of an intravenous catheter placed in a peripheral vessel. The hypothesis stated that clots injected into a peripheral vessel will lodge in the lungs. A subhypothesis was that the clot may lodge anywhere along the circulatory pathway.

Indications of need for the study as shown by the review of literature were the following: (1) the complications resulting from the frequent use of intravenous polyethylene catheters, (2) experimental studies that showed that clots were formed around intravenous catheters, (3) the evidence that intravenous catheters predispose …

Some Aspects Of Carbohydrate Metabolism In The Cercariae Of Schistosoma Mansoni Sambon, 1907, A. Eugene Dunham Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

Cercariac of Schistosoma mansoni were studied for glycogen utilization, uptake of glucose from solution, lactic acid production, and respiration.

Using the anthrone method of determination of carbohydrate, the amount of glycogen used by a single cercaria in 4 hours is determined as 43.2 x 10^-4 μg ± 6.6 x 10^-4 μg.

Glucose was not observed to have been used from solution under the conditions of the experiment, even in the presence of trehalose. The determinations were made by the Glucostat method.

After deproteinization and desugarization, aliquots of supernatant from cercarial suspensions were analyzed for lactic acid using p-phenylphenol …

Poison Plants In The Garden, T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

SOME 18 commonly grown garden plants are known to be toxic and many local home gardens have five or six of them.

Several other species can cause skin ailments.

Responses Of The Normal Human To Infusions Of Plasma From Patients With Graves' Disease, Claude D. Arnaud, Hans A. Kneubuhler, Virginia L. Seiling, Bruce K. Wightman, Norman H. Engbring

Biomedical Sciences Faculty Research and Publications

No abstract provided.

The Net Balance Of Acid In Subjects Given Large Loads Of Acid Or Alkali, Jacob Lemann Jr., Edward J. Lennon, A. David Goodman, John R. Litzow, Arnold S. Relman

Biomedical Sciences Faculty Research and Publications

No abstract provided.

The Effect Of Varying Protein Intake On Trichinella Spiralis Infection In Mice, Clare K. Kwan

Loma Linda University Electronic Theses, Dissertations & Projects

Three hundred Swiss Webster albino mice three weeks of age were placed on low (8%), medium (24%), high (48%) protein levels and a commercial laboratory animal feed, Purina Chow for various lengths of time: (1) simultaneously with infection, and four weeks thereafter, (2) three weeks before infection and throughout the four-week infection period, and (3) six weeks prior to infection and during the infection period. The protein source was casein. Sixty of the 300 mice used served as noninfected controls, and the other 240 were each infected with 400 washed, suspended Trichinella spiralis larvae obtained from a rat by the …

Viral Infections Of Domestic Animals, George A. Young

School of Veterinary and Biomedical Sciences: Faculty Publications

There is a strong tendency in current research on mammalian virus diseases to concentrate on virus activity at a cellular or subcellular level. This trend is summarized adequately by Enders in relation to viral replication as follows: ','The large and ever-increasing volume of published experimental work on viral replication strikingly reveals the central position of this phenomenon in contemporary virological research. There are good reasons, both biological and practical, underlying this intensive effort to understand, i n detail, how a virus particle, without energy transforming apparatus of its own, manages to utilize the metabolic equipment of the cell to produce …

Effects Of Music Therapy And Personal Interaction On The Preoperative Patient, Phyllis Jean Nix

Loma Linda University Electronic Theses, Dissertations & Projects

This study was conducted to discover the effects of (1) an interpersonal relationship and (2) an interpersonal relationship and music therapy on preoperative patients in a selected hospital.

The descriptive survey was chosen as the method of study. A checklist and a tape recording of selected music were used as a tool of research. Two groups of preoperative patients were given nursing care by the researcher. Patients in Group One received care with an aim toward developing an interpersonal relationship, while patients in Group Two received the same as Group One with the addition of music therapy.

Findings revealed a …

The In Vivo Effects Of Hydrazines And Vitamin B6 On The Metabolism Of Gamma_Aminobutyric Acid, Miguel Angel Median

Theses

The discovery of gamma-aminobutyric acid (GABA) in mammalian brain and its rigorous identification was reported in 1950 (1,2,3). Enzymatic experiments with brain acetone powder revealed that GABA was formed by the decarboxylation of glutamic acid and that the enzyme, glutamic acid decarboxylase, required pyridoxal phosphate as the co-factor (4,5). Radioactive tracer studies in vivo and in vitro with glutamic acid and glucose verfied the fact that the former was the precursor of GABA (6,7).

The Conversion Of Cytidylic Acid To Deoxycytidylic Acid In Rat Kidney, Judith Marie Werderitsch

Master's Essays (1922 - )

Evidence was presented in 1949 by Bendich, Getler, and Brown (2), that the free pyrimidine base, cytosine, was not incorporated into the nucleotides of deoxyribonucleic acid (DNA). Further studies by Hammarsten, Reichard, and Saluste (9) with cytidine and those by Roll, Weinfeld, and Carroll (26) with cytidylic acid, showed that the nucleoside and nucleotide derivatives were well incorporated into DNA. These experiments indicated that the conversion of the riboside (or ribotide) to the deoxyribose form had occurred with the nucleosidic linkage intact. This theory was further substantiated by Rose and Schweigert (29) using cytidylic acid incorporation into the total viscera …

Worm Eggs: Cost You Money, E.F. Frolik, E.W. Janike

School of Veterinary and Biomedical Sciences: Faculty Publications

Contents

One Million Eggs Daily.......... 3

Damaging Trip......... 4

Worm Remedies......... 5

Modern Worm Remedies......... 6

A Control Program.......... 8

A Study Of Regeneration Of Peripheral Nerve In The Rat, James C. Jay

Loma Linda University Electronic Theses, Dissertations & Projects

Due to improvements in fixation and embedding techniques a restudy of regenerating peripheral nerve was thought advisable in order to better understand and describe the processes which take place.

Femoral nerves of white Wistar rats were used. The lesions were made by either crushing or severing the nerve. After a period of regeneration, varying from 12 hours to six days, the wound was reopened and the injured portion fixed in situ with 1% osmium tetroxide. The tissues were then removed, dehydrated, embedded and sectioned. The sections were stained and studied with a modified RCA EMU2A electron microscope.

Observations revealed that …

Reversible Changes In The Nem-Reactive--Sh Groups Of Hemoglobin On Oxygenation-Deoxygenation, Samuel A. Morell, Peg Hoffman, Valborg E. Ayers, Fumito Taketa

Biomedical Sciences Faculty Research and Publications

No abstract provided.

Measurement Of Arterial Aging In Hypertensive Patients, Francois M. Abboud, John H. Huston

Biomedical Sciences Faculty Research and Publications

No abstract provided.

Studies Of The Rate Of Disappearance Of Labeled Thyroxine From The Intravascular Compartment, Edward J. Lennon, Norman H. Engbring, William W. Engstrom

Biomedical Sciences Faculty Research and Publications

No abstract provided.

Effect Of Isocaloric Unsaturated Fats On Serum Cholesterol Of Patients Treated With Hypocholesterolemic Agents, Yvonne Marie Hatley

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of a high unsaturated-low saturated fat diet on serum cholesterol levels were studied. Subjects were clinic patients receiving the following hypocholesterolmeic agents: triparanol (MER-29), diildothyroacetic acid (Diac), dextrothyroxine (d-T₄) and 3-methoxy-16, alpha-methyl-1,3,5, (10)-estratriene-16 beta, 17 beta-diol (Manvene or Anvene).

Fifteen hypercholesterolemic patients, eleven of whom were diabetic, were placed on diets with prescribed amounts of unsaturated fat. The caloric distribution was 40 per cent carbohydrate, 20 per cent protein, and 40 per cent fat. The level of unsaturated fat was 70 per cent of the total fat.

Seventy-one per cent of the patients on the hypocholesterolemic …