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The Relationship Between Hla-G Levels And Oxidative Stress Parameters In Patients With Breast Cancer, Sema Bozali̇oğlu, Nedret Kiliç, Zuhal Yildirim, Bi̇lkay Baştürk, Osman Kurukahveci̇oğlu

Turkish Journal of Medical Sciences

To investigate serum HLA-G levels and its correlation with oxidative stress and antioxidant parameters in breast cancer patients. Materials and methods: The patient group consisted of 25 individuals with breast cancer who were operated on in the General Surgery Department of Gazi University’s Faculty of Medicine. Thirty-one individuals who had no history of any kind of cancer, allergic diseases, diabetes, or rheumatic and immunological disease constituted the control group. Results: Results showed that malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and HLA-G levels in the patient group were statistically and significantly high compared to the control group (P < 0.001). While vitamin C levels were significantly lower in the patient group (P < 0.05), an insignificant difference in glutathione peroxidase (GPx) and total sulfhydryl group (R-SH) levels in both groups was observed (P > 0.05). Serum …

The Value Of Apparent Diffusion Coefficient Measurements In The Differential Diagnosis Of Vertebral Bone Marrow Lesions, Gülten Taşkin, Lütfi̇ İncesu, Keri̇m Aslan

Turkish Journal of Medical Sciences

To be able to differentiate benign vertebral bone marrow lesions from malign lesions according to apparent diffusion coefficient (ADC) values, enabling quantitative assessment, and to determine the sensitivity and the specificity in differentiating benign and malign lesions according to the optimal cutoff ADC value. Materials and methods: In 99 patients, 133 lesions in total were included in the study, 59 of which were benign (acute vertebral compression fracture depending on osteoporosis or trauma, spondylitis, atypical hemangioma), and 74 malign (malign compression fracture, metastasis). Each of the benign lesions was compared to the malign lesions. In the statistical analysis, normality tests, …

Rapid Identification Of Aeromonas Species In Stool Samples With Chromogenic Media And Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry: An Institutional Experience, Işin Akyar, Si̇mge Can

Turkish Journal of Medical Sciences

To evaluate the routine use of chromogenic media together with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) in gastrointestinal infections caused by Aeromonas spp. as rapid, practical, cost-effective and reliable methods. Materials and methods: Between August 2007 and March 2012, a total of 13,194 stool specimens of patients were included in the study. The stool samples and the reference strains were inoculated onto Cefsulodin-Irgasan-Novobiocin agar, sheep blood agar, eosin-methylene blue agar, and Hektoen enteric agar media together with CHROMagar Salmonella Plus. All the Salmonella and Aeromonas suspected colonies were identified with an automated system (Phoenix) and MALDI-TOF. Results: …

The In Vitro Determination Of Genotoxicity In Peripheral Lymphocytes Of Welders Exposed To Fumes From Metal Arc Welding, Ceylan Şener, Hali̇l Erhan Eroğlu

Turkish Journal of Medical Sciences

Gas metal arc welding is a widely used method in many industrial areas. In this study, the peripheral blood lymphocytes of 23 welders and 25 nonexposed subjects were monitored for genotoxicity. Materials and methods: The blood samples obtained from the subjects were incubated with a culture medium at 37 °C for 72 h. Cytochalasin-B and BrdU were added for micronucleus and replication index. After incubation, the cultures were harvested, stained, and examined. Results: The micronucleus rate (2.165 ± 1.645) of the welders was quite higher than that of those not exposed (1.352 ± 0.978) (P < 0.01). There was a significant difference between micronucleus rates of smoking and nonsmoking subjects. It was found that as the time of exposure to welding fumes increased, so did the micronucleus rates (2.938 ± 1.723) (P < 0.05). A positive correlation was observed between micronucleus frequency and age. The replication index rate (1.026 ± 0.020) of the welders was higher than that of those not exposed (1.019 ± 0.016) (P = 0.01). Conclusion: It is advised that welders who work with gas metal arc welding be instructed and that necessary protective measures be taken because of the risk caused by metal arc welding fumes.

Serum Interleukin-8, Ca-125 Levels, Neutrophil-To-Lymphocyte Ratios, And Combined Markers In The Diagnosis Of Endometriosis, Cemi̇le Dayangan Sayan, Müzeyyen Gülnur Özakşi̇t, Esma Sarikaya, Özlem Gün Eryilmaz, Leyla Mollamahmutoğlu, Rüya Deveer

Turkish Journal of Medical Sciences

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and …

Asymmetric Dimethylarginine Levels In Allergic Rhinitis And Nasal Polyposis, Mehmet Tosun, Tayfun Apuhan

Turkish Journal of Medical Sciences

Asymmetric dimethylarginine (ADMA) is the major endogenous inhibitor of nitric oxide synthase. We aimed to investigate the ADMA levels in allergic rhinitis (AR) and nasal polyposis (NP). Materials and methods: A total of 29 AR patients, 21 NP patients, and 30 healthy subjects to be used as a control group were enrolled in the study. ADMA was measured in the AR, NP, and control groups with enzyme-linked immunosorbent assay. Any patients or control subjects with coronary artery disease, renal failure, diabetes mellitus, or hypertension were excluded from the study. Results: The mean ADMA serum concentration was 0.52 ± 0.08 µmol/L …

Epidemiology, Clinical Features, And Laboratory Detection Of Mycoplasma Pneumoniae Infection In East Azerbaijan, Iran, Reza Ghotaslou, Simin Sharifi, Mohammad Taghi Akhi, Mohammad Hossein Soroush

Turkish Journal of Medical Sciences

Mycoplasma pneumoniae is involved in the etiology of many respiratory tract infections. This prospective study describes the epidemiology and clinical properties of M. pneumoniae infections in hospitals of the Tabriz University of Medical Sciences. Materials and methods: From May 2009 to November 2010, 200 patients with respiratory tract infections were enrolled into this study. Due to antibiotic use 51 patients were excluded. M. pneumoniae from respiratory infections was detected by culture, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR) assays. Results: M. pneumoniae infection was detected in 9 (6.15%), 8 (5.3%), and 3 (2.01%) of patients by PCR, ELISA, …

Cytokine Associated Neopterin Response Of Peripheral Blood Mononuclear Cells To In Vitro Epstein–Barr Virus Transformation Process Of B Lymphocytes, Lati̇fe Arzu Aral, Ayşegül Atak Yücel

Turkish Journal of Medical Sciences

The Epstein-Barr Virus (EBV) is a human herpes virus that infects B lymphocytes latently and immortalises the cells due to transformation. EBV infection is asymptomatic in childhood, while it may cause a self-limiting lymphoproliferative disorder in adolescence. This study aimed to show the association between in vitro transformation of B lymphocytes via EBV and the levels of neopterin with different accompanying cytokine responses. Materials and methods: Mononuclear cells were isolated from peripheral blood samples of healthy donors and transformed with an EBV secreting cell-line, B95-8. Neopterin, interferon (IFN)-\gamma, tumour necrosis factor (TNF)-\alpha, and interleukin (IL)-6 levels were measured in culture …

Is There Any Effect Of Demographic Features On Development Of Hyperemesis Gravidarum In The Turkish Population?, Zeynep Kamalak, Nermi̇n Köşüş, Aydin Köşüş, Deni̇z Hizli, Ayli̇n Ayrim, Gonca Kurt

Turkish Journal of Medical Sciences

To assess the effect of maternal demographic variables on development of hyperemesis gravidarum (HG) in pregnant Turkish women. Materials and methods: Two hundred consecutive women with HG were defined as the study group, and 200 consecutive pregnant women without any signs or symptoms of HG matched for age, parity, and gestational age were defined as the control group. Personal information, including lifestyle, educational level, occupation, and economic status were obtained via questionnaire. Results: The number of abortions was higher but parity was lower in the HG group. The time interval between 2 pregnancies was significantly shorter in the HG group …

Influence Of Trace Elements And Their Correlation With Semen Quality In Fertile And Infertile Subjects, Vickram Sundaram, Muthugadhalli Srinivas, Jayaraman Gurunathan, Kamini Rao, Ramesh Pathy Maniyan, Sridharan Balasundaram

Turkish Journal of Medical Sciences

There has been increasing curiosity about the appraisal of essential trace elements present in human body fluids and their correlation to human health. Human seminal plasma contains several trace elements that have an imperative role in the normal functioning of the semen. As a result, it is very important to evaluate Zn and other trace elements present in the seminal plasma for the assessment of male infertility. The main objective of this research is to evaluate Zn concentrations and their intercorrelations with semen parameters such as sperm concentration, sperm motility, and normal morphology of the sperm, towards their contribution to …

Effects Of Intranasally Administered Dnsp-11 On The Central Dopamine System Of Normal And Parkinsonian Fischer 344 Rats, James H. Sonne

Theses and Dissertations--Neuroscience

Due to the blood-brain barrier, delivery of many drugs to the brain has required intracranial surgery which is prone to complication. Here we show that Dopamine Neuron Stimulating Peptide 11 (DNSP-11), following non-invasive intranasal administration, protects dopaminergic neurons from a lesion model of Parkinson’s disease in the rat. A significant and dose-dependent increase in an index of dopamine turnover (the ratio of DOPAC to dopamine) was observed in the striatum of normal young adult Fischer 344 rats by whole-tissue neurochemistry compared to vehicle administered controls.

Among animals challenged with a moderate, unilateral 6-hydroxy-dopamine (6-OHDA) lesion of the substantia nigra, those …

Changes In Sleep Architecture And Cognition With Age And Psychosocial Stress: A Study In Fischer 344 Rats, Heather M. Buechel

Theses and Dissertations--Pharmacology and Nutritional Sciences

Changes in both sleep architecture and cognition are common with age. Typically these changes have a negative connotation: sleep fragmentation, insomnia, and deep sleep loss as well as forgetfulness, lack of focus, and even dementia and Alzheimer’s disease. Research has shown that psychosocial stressors, such as isolation from family and friends or loss of a loved one can also have significant negative effects on sleep architecture and cognitive capabilities. This leaves the elderly in a particularly vulnerable situation: suffering from cognitive decline and sleep dysregulation already, and more likely to respond negatively to psychosocial stressors. Taking all of these factors …

Sex Differences In Cell Death And Steroid Hormone Receptors In Cortical Explants, Amanda L. Trout

Theses and Dissertations--Physiology

Estrogens, such as the biologically active 17-b estradiol (E2) have many actions in the male and female brain. Not only does E2 regulate reproductive behavior in adults, it organizes and activates the brains of younger animals in a sex-specific manner. In addition, many human studies have shown E2 to provide protection against a variety of neurological disorders, including stoke. These studies have been controversial and depend largely on the type and timing of hormone replacement. Animal studies are much less controversial and clearly demonstrate a neuroprotective role for E2 following ischemic brain injury. Because much of E2 neuroprotection requires sex …

Evaluation Of Insulin-Like Growth Factor-1 As A Therapeutic Approach For The Treatment Of Traumatic Brain Injury, Shaun W. Carlson

Theses and Dissertations--Physiology

Traumatic brain injury (TBI) is a prevalent CNS neurodegenerative condition that results in lasting neurological dysfunction, including potentially debilitating cognitive impairments. Despite the advancements in understanding the complex damage that can culminate in cellular dysfunction and loss, no therapeutic treatment has been effective in clinical trials, highlighting that new approaches are desperately needed. A therapy that limits cell death while simultaneously promoting reparative mechanisms, including post-traumatic neurogenesis, in the injured brain may have maximum effectiveness in improving recovery of function after TBI. Insulin-like growth factor-1 (IGF-1) is a potent growth factor that has previously been shown to promote recovery of …

Glutamate Dysregulation And Hippocampal Dysfunction In Epileptogenesis, Seth R. Batten

Theses and Dissertations--Medical Sciences

Epileptogenesis is the complex process of the brain developing epileptic acitivity. Due to the role of glutamate and the hippocampus in synaptic plasticity a dysregulation in glutamate neurotransmission and hippocampal dysfunction are implicated in the process of epileptogenesis. However, the exact causal factors that promote epileptogenesis are unknown.

We study presynaptic proteins that regulate glutamate neurotransmission and their role in epileptogenesis. The presynaptic protein, tomosyn, is believed to be a negative regulator of glutamate neurotransmission; however, no one has studied the effects of this protein on glutamate transmission in vivo. Furthermore, evidence suggests that mice lacking tomosyn have a …

Defining The Role Of Reactive Oxygen Species, Nitric Oxide, And Sphingolipid Signaling In Tumor Necrosis Factor - Induced Skeletal Muscle Weakness, Shawn Stasko

Theses and Dissertations--Physiology

In many chronic inflammatory diseases, patients suffer from skeletal muscle weakness, exacerbating their symptoms. Serum levels of tumor necrosis factor-alpha (TNF) and sphingomyelinase are increased, suggesting their possible role in the progression of this weakness. This dissertation focuses on the role that reactive oxygen species (ROS) and nitric oxide (NO) play in mediating TNF-induced skeletal muscle weakness and to what extent sphingolipid signaling mediates cellular response to TNF.

The first aim of this work was to identify which endogenous oxidant species stimulated by TNF contributes to skeletal muscle weakness. In C57BL/6 mice (n=38), intraperitoneal injection of TNF elicited a 25% …

Amalgamation Of Nucleosides And Amino Acids In Antibiotic Biosynthesis, Sandra H. Barnard

Theses and Dissertations--Pharmacy

The rapid increase in antibiotic resistance demands the identification of novel antibiotics with novel targets. One potential antibacterial target is the biosynthesis of peptidoglycan cell wall, which is both ubiquitous and necessary for bacterial survival. Both the caprazamycin-related compounds A-90289 and muraminomicin, as well as the capuramycin-related compounds A-503083 and A-102395 are potent inhibitors of the translocase I enzyme, one of the key enzymes required for cell wall biosynthesis. The caprazamycin-related compounds contain a core nonproteinogen b-hydroxy-a-amino acid referred to as 5’-C-glycyluridine (GlyU). Residing within the biosynthetic gene clusters of the aforementioned compounds is a shared open reading …

Microglia Activation In A Rodent Model Of An Alcohol Use Disorder: The Importance Of Phenotype, Initiation, And Duration Of Activation, Simon A. Marshall

Theses and Dissertations--Pharmacy

Chronic ethanol exposure results in neuroadaptations that drive the progression of an alcohol use disorder (AUD). One such driving force is alcohol-induced neurodegeneration. Neuroinflammation has been proposed as a mechanism underlying this damage. Although neuroinflammation is a physiological response to damage, overactivation of its pathways can lead to neurodegeneration. A hallmark indicator of neuroinflammation is microglial activation, but microglial activation is a heterogeneous continuum of phenotypes that can promote or inhibit neuroinflammation. Furthermore acute microglial activation is necessary to restore homeostasis, but prolonged activation can exacerbate damage. The diversity of microglia makes both the level and timecourse of activation vital …

Molecular Mechanisms Related To Endotoxemia In Primary Human Cardiomyocytes In Culture, Atijah J. Collins

PCOM Biomedical Studies Student Scholarship

Cardiovascular disease (CVD) is the leading cause of death in the United States and has been for the past 80 years. Development of novel therapeutic agents to address the large number of CVD deaths requires an in depth understanding of the structural and functional properties of human cardiomyocytes. Over the last few years we have been developing an in vitro paradigm to assess molecular cardiodynamics in Primary Human Cardiomyocyte in culture (PHCC). We tested the hypothesis whether endotoxemia would exhibit a marked decrease in contractile proteins and cause apoptosis in PHCC. In the current series of experiments, we induced endotoxemia …

Expression Of Cyclin D1, P27, P21, Bcl-2, And P53 In Laryngeal Squamous Cell Carcinoma And An Investigation Of The Correlation With Conventional Prognostic Factors, Gülçi̇n Şi̇mşek, Ünsal Han, Bi̇nnur Önal, Fatma Fulya Köybaşioğlu, İstemi̇han Akin, Muharrem Dağli

Turkish Journal of Medical Sciences

Because it is a multistep process, in carcinogenesis it is necessary to determine key genes such as cyclin D1, p27, p21, bcl-2, and p53 that are responsible for uncontrolled proliferation and other mechanisms. The aim of this study was to examine the correlation between the anomalous accumulation of these proteins and the prognosis of laryngeal carcinomas. Materials and methods: In our study, cyclin D1, p27, p21, bcl-2, and p53 expressions were analyzed immunohistochemically in laryngeal squamous cell carcinomas, and the findings were compared with conventional prognostic parameters such as patient age, sex, tumor localization and diameter, tumor differentiation, lymph node …

Leptin Regulation Of Pubertal Maturation In Intact And Pinealectomized Female Rats, Emi̇ne Kaçar, Si̇ğnem Eyuboğlu Di̇nç, Bayram Yilmaz, Haluk Keleşti̇mur

Turkish Journal of Medical Sciences

To explore the roles of leptin and melatonin in early pubertal maturation. Materials and methods: Wistar female rats were used as experimental animals. Leptin was subcutaneously infused for 28 days through osmotic minipumps starting from postnatal day 15 (preweaning). Pinealectomy was performed on postnatal day 21 (weaning), and the animals were decapitated when estrus was detected by vaginal smearing. Results: Chronic preweaning, by peripheral infusion of leptin through subcutaneous routes, advanced the onset of puberty in leptin-treated sham and pinealectomized groups as determined by vaginal opening, while causing no significant change in serum estradiol levels and uterus weight. Mean body …

A Potential Association Between The Number Of Ca Repeats In The Promoter Region Of The Adamts9 Gene With Lymphatic Metastasis Of Breast Cancer, Mi̇kdat Bozer, Fatma Aşik, Muradi̇ye Acar, Hacer Haltaş, Si̇bel Yeni̇dünya, Meti̇n Canbal, Vehap Topçu, Muhammet Ramazan Yi̇ği̇toğlu, Mehmet Gündüz, Esra Gündüz, Satoshi Hirohata, Kadi̇r Demi̇rcan

Turkish Journal of Medical Sciences

We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in …

The Roles Of Primary Cilia In Polycystic Kidney Disease, Samred H. Kathem, Ashraf M. Mohieldin, Surya M. Nauli

Pharmacy Faculty Articles and Research

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder that results in progressive renal cyst formation with ultimate loss of renal function and other systemic disorders. These systemic disorders include abnormalities in cardiovascular, portal, pancreatic and gastrointestinal systems. ADPKD is considered to be among the ciliopathy diseases due to the association with abnormal primary cilia function. In order to understand the full course of primary cilia and its association with ADPKD, the structure, functions and role of primary cilia have been meticulously investigated. As a result, the focus on primary cilia has emerged to support the vital roles …

Rhodopsin Trafficking And Retinal Function, Nicholas Joseph Reish

All ETDs from UAB

The health and maintenance of rod photoreceptors depends on the high-fidelity vectorial transport of rhodopsin from its site of synthesis in the inner segment to its final resting place in the outer segment disks. Multiple molecular interactions play a role in this process, including the interaction of the small GTPase rab11a with rhodopsin that was first described in vertebrates in amphibians. We found that the interaction of the small GTPase rab11a and rhodopsin is conserved in mammalian retina. This interaction is direct, is abrogated by human disease-causing truncation mutations in rhodopsin, and does not depend on the nucleotide binding status …

The Impairment Of Macrophage-To-Feces Reverse Cholesterol Transport During Inflammation Does Not Depend On Serum Amyloid A, Maria C. De Beer, Joanne M. Wroblewski, Victoria P. Noffsinger, Ailing Ji, Jason M. Meyer, Deneys R. Van Der Westhuyzen, Frederick C. De Beer, Nancy R. Webb

Saha Cardiovascular Research Center Faculty Publications

Studies suggest that inflammation impairs reverse cholesterol transport (RCT). We investigated whether serum amyloid A (SAA) contributes to this impairment using an established macrophage-to-feces RCT model. Wild-type (WT) mice and mice deficient in SAA1.1 and SAA2.1 (SAAKO) were injected intraperitoneally with ³H-cholesterol-labeled J774 macrophages 4 hr after administration of LPS or buffered saline. ³H-cholesterol in plasma 4 hr after macrophage injection was significantly reduced in both WT and SAAKO mice injected with LPS, but this was not associated with a reduced capacity of serum from LPS-injected mice to promote macrophage cholesterol efflux in vitro. Hepatic accumulation of ^{3 …}

Thc-Mediated Induction Of Δfosb And Its Modulation Of Cb1r Signaling And Adaptation, Lazenka Matthew

Theses and Dissertations

The main psychoactive and therapeutic effects of Δ9-tetrahydrocannabinol (THC) are mediated through cannabinoid type 1 receptors (CB1Rs). The therapeutic uses of THC are mitigated by the development of tolerance to these therapeutic effects, whereas tolerance does not readily develop to some of the side-effects of THC, like motor impairment and reward. The development of tolerance occurs through adaptations at CB1Rs, which include desensitization (G-protein uncoupling) and downregulation (receptor degradation). Brain region-dependent differences in THC-mediated adaptations are proposed to explain the differences in tolerance to various THC-mediated effects. These studies focused on whether ΔFosB, a stable transcription factor, could regulate CB1R …

The Characterisation Of Pax3 Expressant Cells In Adult Peripheral Nerve [Journal Article], Judith Blake, Melanie Ziman

Research outputs 2013

Pax3 has numerous integral functions in embryonic tissue morphogenesis and knowledge of its complex function in cells of adult tissue continues to unfold. Across a variety of adult tissue lineages, the role of Pax3 is principally linked to maintenance of the tissue’s resident stem/progenitor cell population. In adult peripheral nerves, Pax3 is reported to be expressed in nonmyelinating Schwann cells, however, little is known about the purpose of this expression. Based on the evidence of the role of Pax3 in other adult tissue stem and progenitor cells, it was hypothesised that the cells in adult peripheral nerve that express Pax3 …

Impedance Changes In Biceps Brachii Due To Isometric Contractions And Muscle Fatigue Using Electrical Impedance Myography (Eim), Travis Orth

College of Graduate Studies: Theses & Dissertations

Electrical impedance myography (EIM) is a non-invasive technique used to evaluate neuromuscular conditions by using a quantitative parameter called impedance (Z). It relies upon the application and measurement of high-frequency, low-intensity electrical current imbedded over a localized muscle to determine its opposition to current flow. In brevity, impedance determines the resistance of muscle fibers due to changes in muscle composition. The objective of this thesis was to establish a relationship between muscles at rest and during isometric contractions at various force levels(25%, 50%, and 100% of maximum voluntary contraction) of the biceps brachii over a multifrequency spectrum. Impedance measurements due …

Insulin Resistance Impairs Response To Doxazosin Therapy In Men With Benign Prostatic Hyperplasia, Cevdet Serkan Gökkaya, Çeti̇n Volkan Özteki̇n, Cüneyt Özden, Emi̇n Öztürk, Bi̇nhan Kağan Aktaş, Ali̇ Memi̇ş

Turkish Journal of Medical Sciences

To evaluate the effects of insulin resistance (IR) on outcomes of doxazosin treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Materials and methods: This prospective study included 64 patients with LUTS due to BPH. LUTS were evaluated using the international prostate symptom score (IPSS) and maximum flow rate (Qmax) in uroflowmetry. Diagnosis of IR was achieved using homeostasis model assessment (HOMA) score and patients were grouped with respect to absence (group 1, n = 44) or presence (group 2, n = 20) of IR. Patients were evaluated before and after 3 months of daily doxazosin …

Molecular Characterization Of Acanthamoeba Isolated From Kayseri Well Water, Sali̇h Kuk, Süleyman Yazar, Süheyla Doğan, Ülfet Çeti̇nkaya, Çağri Şakalar

Turkish Journal of Medical Sciences

Potentially pathogenic free-living amoebae have a cosmopolitan distribution in soil, dust, air, and water. Generally, environmental free-living amoebae do not threaten human health. This study aimed to investigate the presence of Acanthamoeba in well waters drawn from different locations in Kayseri, Turkey, which are mainly used for drinking or irrigation by the residents in the region. Materials and methods: Twenty-nine samples, including 26 well water sediment samples and 3 tap water samples as the control, were collected from 3 different locations. Melting snow feeds 5, rain water 18, and tap water 3 of these wells. Results: Five of 26 well …