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Articles 15901 - 15930 of 24788
Full-Text Articles in Entire DC Network
Role Of Chondrocyte Antigen Presentation In Osteoarthritis, Panjana Sengprasert
Role Of Chondrocyte Antigen Presentation In Osteoarthritis, Panjana Sengprasert
Chulalongkorn University Theses and Dissertations (Chula ETD)
Osteoarthritis (OA) is an inflammatory disorder characterized by degeneration of joint components, especially the cartilage. Chondrocytes are found in articular cartilage and play a role in cartilage production and degradation. Several studies found that chondrocytes not only control the cartilage metabolism, but also play a role in immune responses. However, the role of chondrocytes in the pathogenesis of OA is still unclear. In this study, we investigated the responses of OA chondrocytes after stimulating with IFN-γ and proteoglycan aggrecan and also determined antigen presentation function of chondrocytes to present proteoglycan aggrecan peptide to T cells. We found that OA chondrocyte …
Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson
Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson
Honors Theses and Capstones
Overall, approximately 95 percent of reported cases of vector-borne disease were associated with ticks, making these the most medically important group of arthropods in the United States.1 Despite the prevalence of tick-borne infections, the process for the diagnosis of this condition is not well studied. This study aims to analyze data from a pool of 100 patients who underwent testing for tick-borne disease in the same institution in Dover, New Hampshire during the most recent peak tick season of 2019. Information utilized in this study included: patient age, sex, location of testing (inpatient versus outpatient), diagnostic testing methods used …
Anterior Cruciate Ligament Injury-Induced Alterations In Inflammation And Muscle Physiology, Emily R. Hunt
Anterior Cruciate Ligament Injury-Induced Alterations In Inflammation And Muscle Physiology, Emily R. Hunt
Theses and Dissertations--Rehabilitation Sciences
Long term weakness and atrophy of the quadriceps muscle are a direct result of anterior cruciate ligament (ACL) injuries and persist for up to 10 years post injury. Muscle atrophy ensues regardless of ligamentous reconstruction surgery, indicating that muscle atrophy following injury is a function of the ligament rupture and not reconstruction surgery. Elucidating the mechanisms underlying quadriceps atrophy following ACL rupture is crucial for developing interventions to restore proper quadriceps size and mitigate weakness thereby allowing for improved patient function. In addition to understanding the specific mechanisms that contribute to quadriceps atrophy following ACL rupture, the timing of atrophic …
Determining The Role Of Satellite Cells During Skeletal Muscle Adaptation, Davis A. Englund
Determining The Role Of Satellite Cells During Skeletal Muscle Adaptation, Davis A. Englund
Theses and Dissertations--Rehabilitation Sciences
Physical inactivity, advancing age, limb immobilization, degenerative diseases and various systemic diseases (many cancers, sepsis, HIV, COPD, kidney disease) all lead to skeletal muscle wasting. The loss of muscle mass is of major clinical importance because it leads to an increased risk for morbidity, disability, and the loss of independence; collectively contributing to a substantive increase in healthcare utilization and cost. The prevalence of cachexia (disease-induced muscle wasting) can reach as high as 80% in certain patient populations and the average cost per hospital stay is $4,641 more than in non-cachectic patients. Direct healthcare costs attributable to sarcopenia were estimated …
A Short Remark On Multipurpose Laser Therapy “Helios” In Ukraine And Its Potential Application For Treatment Of Neurology Disorders, Florentin Smarandache, Volodymyr Krasnoholovets, Victor Christianto, Rizha Vitania, The Houw Liong
A Short Remark On Multipurpose Laser Therapy “Helios” In Ukraine And Its Potential Application For Treatment Of Neurology Disorders, Florentin Smarandache, Volodymyr Krasnoholovets, Victor Christianto, Rizha Vitania, The Houw Liong
Branch Mathematics and Statistics Faculty and Staff Publications
However, a truly multipurpose laser therapy method is very rarely available. Here we introduce a multipurpose laser therapy device in Ukraine, which is capable to take care a multitude of diseases. It is called “Helios”, by one of us (VK). We also give a case where a patient who suffered from Covid-19 has been treated successfully until he is recovered to healthy condition. In the last section we also discuss potential future application of Helios for other fields; i.e. neurology disorders.
Midkine Level May Be Used As A Noninvasive Biomarker In Crohn's Disease, Murat Keki̇lli̇, Alpaslan Tanoğlu, Fati̇h Karaahmet, Zeynal Doğan, Murat Can, Abdurrahi̇m Sayilir, Başak Çakal, Tolga Düzenli̇, Yavuz Beyazi̇t
Midkine Level May Be Used As A Noninvasive Biomarker In Crohn's Disease, Murat Keki̇lli̇, Alpaslan Tanoğlu, Fati̇h Karaahmet, Zeynal Doğan, Murat Can, Abdurrahi̇m Sayilir, Başak Çakal, Tolga Düzenli̇, Yavuz Beyazi̇t
Turkish Journal of Medical Sciences
Background/aim: Crohn's disease (CD) is a kind of inflammatory bowel disease. Midkine (MDK) is an endogenous inflammatory marker. We aimed to investigate the relationship between MDK levels and inflammation and hence determine whether MDK can be used as a noninvasive biomarker in active CD. Materials and methods: Sixty-five consecutive patients over the age of 18 with CD and 36 healthy controls were included in this study. CD patients' venous blood samples were taken before treatment. Serum MDK levels were determined in human plasma samples by enzyme-linked immunosorbent assay (ELISA) method. Results: The mean age of the study patients was 44.8 …
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Turkish Journal of Medical Sciences
Background/aim: The serum fatty acid binding protein 4 (FABP-4) level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin (IL)-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, …
Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar
Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar
Turkish Journal of Medical Sciences
Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The …
The Effect Of Vitamin D Status On Different Neuromuscular Blocker Agents Reverse Time, İlknur Sui̇di̇ye Yorulmaz, Yavuz Demi̇raran, Onur Özlü, Burhan Dost
The Effect Of Vitamin D Status On Different Neuromuscular Blocker Agents Reverse Time, İlknur Sui̇di̇ye Yorulmaz, Yavuz Demi̇raran, Onur Özlü, Burhan Dost
Turkish Journal of Medical Sciences
Background/aim: This study is aimed to investigate the effects of vitamin D levels on sugammadex and neostigmine reversal times. Material and methods: Eighty patients between the ages of 18 and 65 years, with ASA I-III status who were undergoing surgery under general anesthesia were included in the study. A double blind fashion was used to randomly divide all the patients into two groups. At the end of the operation, sugammadex 2 mg/kg was administered to one group (Group sugammadex) and atropine and neostigmine was administered to the other group (Group neostigmine) intravenously. In the data analysis stage, the group was …
Horse Allergen Sensitivity And Respiratory Symptoms Among Horse Farm Workers, Burcu Baran Ketenci̇oğlu, İnsu Yilmaz, Nuri̇ Tutar, İnci̇ Gülmez, Fatma Sema Oymak
Horse Allergen Sensitivity And Respiratory Symptoms Among Horse Farm Workers, Burcu Baran Ketenci̇oğlu, İnsu Yilmaz, Nuri̇ Tutar, İnci̇ Gülmez, Fatma Sema Oymak
Turkish Journal of Medical Sciences
Background/aim: Sensitivity and symptoms related to animal proteins have been investigated in various occupational groups. However, data from horse farm workers are limited. We aimed to determine horse allergen sensitivity in the horse farm workers, and to evaluate its relationship with respiratory symptoms and functional parameters. Materials and methods: A total of 110 subjects were enrolled in the study. The study group consisted of 80 horse farm workers. Face-to-face surveys, skin prick tests (SPT), and pulmonary function tests (PFT) were performed in the study group. Control group consisted of 30 healthy subjects. SPT and PFTs were also performed for control …
Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode, Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çeti̇n, Ebru Kaynar Tunçel, Bi̇rşen Bi̇lgi̇ci̇, Arzu Karaustaoğlu
Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode, Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çeti̇n, Ebru Kaynar Tunçel, Bi̇rşen Bi̇lgi̇ci̇, Arzu Karaustaoğlu
Turkish Journal of Medical Sciences
Background/aim: Neurotrophins are one of the most important molecule groups affecting cerebral neuroplasticity. The amount of evidence about the role of changes in neuroplasticity in the pathophysiology of bipolar disease is growing. Materials and methods: We measured serum levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), glial cell-line derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), fibroblast growth factor (FGF)-2, neuritin 1 (Nrn 1) in bipolar 1 manic episode patients (n = 45) and healthy control group. Results: When controlled for age, BMI and cortisol, it was found that the serum …
Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu
Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu
Turkish Journal of Medical Sciences
Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF. Materials and methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein (CRP) and pulmonary function tests (PFTs) was investigated. Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in …
Dti-Mri Findings In Synthetic Cannabinoid Users, Fatma Di̇lek Gökharman, Sonay Aydin, Sali̇h Ci̇hat Paltun, Erdem Fati̇hoğlu, Şafak Yalçin Şahi̇ner, Pinar Nerci̇s Koşar
Dti-Mri Findings In Synthetic Cannabinoid Users, Fatma Di̇lek Gökharman, Sonay Aydin, Sali̇h Ci̇hat Paltun, Erdem Fati̇hoğlu, Şafak Yalçin Şahi̇ner, Pinar Nerci̇s Koşar
Turkish Journal of Medical Sciences
Background/aim: Synthetic cannabinoids (SCs) are full agonists of both cannabinoid receptors. Conventional magnetic resonance imaging (MRI) findings of SC users are mainly defined as diffusion restriction and T2/FLAIR hyperintensity. Diffusion tensor imaging (DTI) studies examining SC users have shown contradictory results. The aim of this study was to define white matter (WM) changes of SC users using DTI. Materials and methods: The study included 22 patients with a history of using SC for 5-37 months, and 22 healthy, age and sex- matched control subjects. A total of 41 diffusion gradient directions were used in the acquisition of diffusion imaging data. …
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Turkish Journal of Medical Sciences
Background/aim: We aimed to explore the roles of glycoprotein glycosylation in the pathogenesis of Kashin-Beck disease (KBD), and evaluated the effectiveness of sodium hyaluronate treatment. Materials and methods: Blood and saliva were collected from KBD patients before and after the injection of sodium hyaluronate. Normal healthy subjects were included as controls. Saliva and serum lectin microarrays and saliva and serum microarray verifications were used to screen and confirm the differences in lectin levels among the three groups. Results: In saliva lectin microarray, bindings to Sophora japonica agglutinin (SJA), Griffonia (Bandeiraea) simplicifolia lectin I (GSL-I), Euonymus europaeus lectin (EEL), Maackia amurensis …
Investigation The Potential Use Of Silver Nanoparticles Synthesized By Propolis Extract As N-Acyl-Homoserine Lactone-Mediated Quorum Sensing Systems Inhibitor, Sedef İlk, Gamze Tan, Ezgi̇ Emül, Necdet Sağlam
Investigation The Potential Use Of Silver Nanoparticles Synthesized By Propolis Extract As N-Acyl-Homoserine Lactone-Mediated Quorum Sensing Systems Inhibitor, Sedef İlk, Gamze Tan, Ezgi̇ Emül, Necdet Sağlam
Turkish Journal of Medical Sciences
Background/aim: Quorum sensing (QS) is a chemical communication process that bacteria use to regulate virulence. Inhibition of QS (antiQS) overcomes the pathogenicity of bacteria. Silver nanoparticles (AgNPs) have been used as antimicrobials against pathogens, but have not been used against QS-mediated bacterial infection. Also, studies have been carried out on the inhibitory effects of propolis based structures on pathogen growth, but no studies have been found on their potential use as QS inhibitor. The present study aims to investigate the synthesis and characterization of silver nanoparticles (AgNPs) reduced with propolis extract (P-AgNPs) and evaluation of their antimicrobial and, for the …
Baicalein Nanofiber Scaffold Containing Hyaluronic Acid And Polyvinyl Alcohol: Preparation And Evaluation, Kamel Bachimam, Ezgi̇ Emül, Necdet Sağlam, Feza Korkusuz
Baicalein Nanofiber Scaffold Containing Hyaluronic Acid And Polyvinyl Alcohol: Preparation And Evaluation, Kamel Bachimam, Ezgi̇ Emül, Necdet Sağlam, Feza Korkusuz
Turkish Journal of Medical Sciences
Background/aim: Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue. Materials and methods: Electrospinning method was used in order to produce nanofibers from different kinds of polymers; Hyaluronic …
Alterations In Follicular Fluid Bmp-15 Rna Expression In Women Undergoing Controlled Ovarian Hyperstimulation, Şükri̇ye Derya Deveci̇
Alterations In Follicular Fluid Bmp-15 Rna Expression In Women Undergoing Controlled Ovarian Hyperstimulation, Şükri̇ye Derya Deveci̇
Turkish Journal of Medical Sciences
Background/aim: Bone morphogenetic protein-15 (BMP-15) is one of the maturation indicators of the ovarian follicular pool. The aim of this study was to investigate the possible difference of follicular fluid (FF) BMP-15 RNA expression among low, normal, and high responder women attending controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycles.Materials and methods: This cross-sectional study was conducted with 75 FFs of COH-ICSI cycles performed at the IVF Unit of University Hospital. Twenty FF from low response (group 1), 27 FF from normal response (group 2), and 28 FF from high response (group 3) were recruited for the study between September 2014 …
Antioxidant Effects Of Dexmedetomidine Against Hydrogen Peroxide-Induced Dna Damage In Vitro By Alkaline Comet Assay, Mustafa Sirri Kotanoğlu, Ela Kadioğlu, Esra Emerce, Çeti̇n Kaymak, Ayşe Özcan, Hülya Başar
Antioxidant Effects Of Dexmedetomidine Against Hydrogen Peroxide-Induced Dna Damage In Vitro By Alkaline Comet Assay, Mustafa Sirri Kotanoğlu, Ela Kadioğlu, Esra Emerce, Çeti̇n Kaymak, Ayşe Özcan, Hülya Başar
Turkish Journal of Medical Sciences
Background/aim: Dexmedetomidine (DEX) is an alpha-2 adrenergic agonist that is commonly used as a sedative and anesthetic. The protective effects of DEX against oxidative damage under both in vitro and in vivo conditions have been demonstrated. It was aimed to evaluate and compare the protective effects of DEX and vitamin C (Vit C) on DNA against H2O2-induced DNA damage in human lymphocyte cell cultures in vitro by alkaline Comet assay.Materials and methods: Lymphocyte cell cultures were divided into 5 groups, as the negative control, solvent control, positive control, hydrogen peroxide (H2O2; 150 µM) + DEX (1 µM; 2.5 µM; 5 …
What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga
What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of hysterectomy on rat ovaries and the possible protective role of peroxisome proliferator-activated receptor gamma (PPAR-?) agonist-rosiglitazone against ovarian reserve decrement.Materials and methods: Forty-five adult Wistar albino rats were randomly divided into three groups. Hysterectomy was performed (n = 15) in group 1 [H]; 1 mg/kg/day PPAR-? agonist/rosiglitazone was used for 50 days after hysterectomy (n = 15) in group 2 [H + R]; a sham operation was performed (n = 15) in group 3 [control, C]. Blood samples were collected for anti-Müllerian hormone (AMH) evaluation in all groups and simultaneous ovarian Doppler examination was …
A Study Of Drynariafortunei In Modulation Of Bmp-2 Signalling By Bone Tissue Engineering, Guo-Chung Dong, Tzn-Yuan Ma, Chi-Han Li, Chih-Ying Chi, Chao-Ming Su, Chih-Ling Huang, Yan-Hsiung Wang, Tzer-Ming Lee
A Study Of Drynariafortunei In Modulation Of Bmp-2 Signalling By Bone Tissue Engineering, Guo-Chung Dong, Tzn-Yuan Ma, Chi-Han Li, Chih-Ying Chi, Chao-Ming Su, Chih-Ling Huang, Yan-Hsiung Wang, Tzer-Ming Lee
Turkish Journal of Medical Sciences
Background/aim: Drynaria fortunei (Gusuibu; GSB) is a popular traditional Chinese medicine used for bone repair. An increasing number of studies have reported that GSB induces osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs). These results provide insight into the application of GSB for bone tissue engineering techniques used to repair large bone defects. However, few studies have described the molecular mechanisms of GSB.Materials and methods: In the present study, the effects of GSB and naringin, a marker compound, on the binding of BMP-2 to BMPR and BMP-2-derived signal transduction were investigated using surface plasmon resonance (SPR) and coculturing with …
Surface Enhanced Raman Spectroscopy As A Novel Tool For Rapid Quantification Of Heroin And Metabolites In Saliva, Ramazan Akçan, Mahmut Şeri̇f Yildirim, Hasan İlhan, Burcu Güven, Uğur Tamer, Necdet Sağlam
Surface Enhanced Raman Spectroscopy As A Novel Tool For Rapid Quantification Of Heroin And Metabolites In Saliva, Ramazan Akçan, Mahmut Şeri̇f Yildirim, Hasan İlhan, Burcu Güven, Uğur Tamer, Necdet Sağlam
Turkish Journal of Medical Sciences
Background: Heroin can be detected and quantified by certain analytical methods, however, forensic professionals and criminal laboratories study for cheaper and faster detection tools. Surface-enhanced Raman spectroscopy (SERS) rises as a possible alternative tool with its widening application spectra. There are few studies regarding Raman and SERS spectra of heroin and its metabolites, which are unfortunately controversial. In this study, we compared five different surfaces in order to find out more efficient Raman-active substrate for opiate detection and rapid quantification of heroin and its metabolites in saliva.Materials and methods: Morphine standard material was used to identify proper surface for SERS …
Posthepatectomy Liver Failure, İlhan Ocak, Serdar Topaloğlu, Koray Acarli
Posthepatectomy Liver Failure, İlhan Ocak, Serdar Topaloğlu, Koray Acarli
Turkish Journal of Medical Sciences
Liver surgery is one of the most complex surgical interventions with high risk and potential for complications. Posthepatectomy liver failure (PHLF) is a serious complication of liver surgery that occurs in about 10% of patients undergoing major liver surgery. It is the main source of morbidity and mortality. Appropriate surgical techniques and intensive care management are important in preventing PHLF. Early start of the liver support systems is very important for the PHLF patient to recover, survive, or be ready for a liver transplant. Nonbiological and biological liver support systems should be used in PHLF to prepare for treatment or …
Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney
Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney
Turkish Journal of Medical Sciences
The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline …
Evidence That Osteogenic And Neurogenic Differentiation Capability Of Epidural Adiposetissue-Derived Stem Cells Was More Pronounced Than In Subcutaneous Cells, Bi̇lgehan Solmaz, Ali̇ Şahi̇n, Taha Keleştemur, Ertuğrul Kiliç, Erkan Kaptanoğlu
Evidence That Osteogenic And Neurogenic Differentiation Capability Of Epidural Adiposetissue-Derived Stem Cells Was More Pronounced Than In Subcutaneous Cells, Bi̇lgehan Solmaz, Ali̇ Şahi̇n, Taha Keleştemur, Ertuğrul Kiliç, Erkan Kaptanoğlu
Turkish Journal of Medical Sciences
Background/aim: The management of dura-related complications, such as the repairment of dural tears and reconstruction of large dural defects, remain the most challenging subjects of neurosurgery. Numerous surgical techniques and synthetic or autologous adjuvant materials have emerged as an adjunct to primary dural closure, which may result in further complications or side effects. Therefore, the subcutaneous autologous free adipose tissue graft has been recommended for the protection of the central nervous system and repairment of the meninges. In addition, human adipose tissue is also a source of multipotent stem cells. However, epidural adipose tissue seems more promising than subcutaneous because …
Cd34+ Hematopoietic Progenitor Cell Dose As A Predictor Of Engraftment And Survival Inmultiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Yahya Büyükaşik, Mehmet Turgut, Sali̇h Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Hakan Göker
Cd34+ Hematopoietic Progenitor Cell Dose As A Predictor Of Engraftment And Survival Inmultiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Yahya Büyükaşik, Mehmet Turgut, Sali̇h Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Hakan Göker
Turkish Journal of Medical Sciences
Background/aim: High-dose melphalan and autologous hematopoietic stem cell transplantation (AHSCT) is the standard treatment strategy for multiple myeloma (MM) patients who are eligible for it. The recommended dose of CD34+ hematopoietic progenitor cells (HPCs) for adequate engraftment is above 2 × 106 /kg. The aim of this study was to evaluate the relationship between the dose of CD34+ HPCs and survival in MM patients who underwent AHSCT at a tertiary care center. Materials and methods: Enrolled in this study were 271 MM patients who underwent AHSCT between 2003 and 2019. Clinical characteristics of the patients, disease status pre-AHSCT, reinfused CD34+ …
Anakinra, An Interleukin-1 Receptor Antagonist, Increases The Morphine Analgesic Effectand Decreases Morphine Tolerance Development By Modulating Oxidative Stress Andendoplasmic Reticulum Stress In Rats, Onur Avci, Ahmet Şevki̇ Taşkiran
Anakinra, An Interleukin-1 Receptor Antagonist, Increases The Morphine Analgesic Effectand Decreases Morphine Tolerance Development By Modulating Oxidative Stress Andendoplasmic Reticulum Stress In Rats, Onur Avci, Ahmet Şevki̇ Taşkiran
Turkish Journal of Medical Sciences
Background/aim: Recent studies have shown that inflammation plays a role in morphine analgesia and tolerance development. Anakinra is a competitive inhibitor of IL-1 receptors and an antiinflammatory protein regulating IL-1ß's biological activity by avoiding signal transduction. In this study, we aimed to examine the effects of anakinra on morphine analgesia and tolerance. Materials and methods: In this study, 36 Wistar Albino (230-250 g) male rats were used. Animals were divided into 6 groups: saline (S), 100 mg/kg anakinra (A), 5mg/kg morphine (M), M+A, morphine tolerance (MT), and MT+A. The resulting analgesic effect was measured with hot plate and tail-flick analgesia …
Familial Mediterranean Fever, From Pathogenesis To Treatment: A Contemporary Review, Abdurrahman Tufan, Helen Lachmann
Familial Mediterranean Fever, From Pathogenesis To Treatment: A Contemporary Review, Abdurrahman Tufan, Helen Lachmann
Turkish Journal of Medical Sciences
Familial Mediterranean fever (FMF) (OMIM #249100) is the most common hereditary autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV gene which encodes an immune regulatory protein, pyrin. Over the last few years, we have witnessed several new developments in the pathogenesis, genetic testing, diagnosis, comorbidities, disease related damage and treatment approaches to FMF. Elucidation of some of the pathogenic mechanisms has led to the discovery of pathways involved in inflammatory, metabolic, cardiovascular and degenerative diseases. The use of next generation sequencing in FMF has revealed many new gene variants whose clinical significance may …
Immune Gene Therapy Of Cancer, Hakan Akbulut
Immune Gene Therapy Of Cancer, Hakan Akbulut
Turkish Journal of Medical Sciences
Cancer gene therapy emerged as a promising treatment modality 3 decades ago. However, the failure of the first gene therapy trials in cancer treatment has decreased its popularity. Likewise, immunotherapy has followed a similar course. While it was a popular and promising treatment with IL-2 and interferon and cancer vaccines in the 1980s, it later lost its popularity. Immunotherapy became one of the main options for cancer treatment with the successful use of immune checkpoint inhibitors in clinics approximately 10 years ago. The success of immunotherapy has increased even more with the introduction of cancer gene therapy methods in this …
The Role Of Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 9 In Enhanced Aggressiveness Of Hexavalent Chromium Transformed Bronchial Epithelial Cells, Peter Van Wie
Theses and Dissertations--Toxicology and Cancer Biology
Hexavalent chromium (Cr(VI)) is classified as a confirmed human carcinogen by the International Agency for Research and Cancer (IARC) and by the U.S. Environmental Protection Agency (EPA). Chronic exposure to (Cr(VI)) causes malignant cell transformation in human bronchial epithelial BEAS-2B cells. These Cr(VI)-transformed cells exhibit a highly aggressive phenotype including increased migration, invasion, and angiogenesis. The Cas family protein neuronal precursor developmentally down regulated protein 9 (NEDD9/Cas-L/HEF1) was dramatically overexpressed in Cr(VI)-transformed cells compared to normal BEAS-2B cells. Knockdown of NEDD9 by its shRNA reduced migration and invasion in vitro measured by migration and invasion assays. shNEDD9 reduced tumor formation …
The Coulter Principle: For The Good Of Humankind, Marshall Graham
The Coulter Principle: For The Good Of Humankind, Marshall Graham
Theses and Dissertations--History
The atomic bombings of Hiroshima and Nagasaki in August 1945 made Wallace H. Coulter abruptly comprehend the critical need for rapid and accurate blood-cell counts in providing care for victims of radiation exposure. This thesis documents the unwritten story of his journey from that comprehension through his invention and implementation of the Coulter Principle, its commercialization in the first widely available automated blood-cell counter, and elaboration of that ground-breaking counter into increasingly sophisticated instrumentation for analysis not only of blood cells, but of particles involved in many other scientific disciplines. International cold-war politics and the burgeoning of increasingly powerful nuclear …