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Radiation Induces Metabolic Dysregulation In Pulmonary Fibroblasts, Josly Pierre-Louis, Margaret A. T. Freeberg, Jane K. Rebman, Thomas H. Thatcher, Patricia J. Sime

Graduate Research Posters

Rationale: Exposure of the lung to ionizing radiation, such as during radiotherapy, can result in pulmonary fibrosis (PF), which has few treatment options. PF is characterized by an accumulation of extracellular matrix proteins that form scar tissue, resulting in dyspnea, disruption of gas exchange, and even death. We and others have shown that metabolic reprogramming is a hallmark of idiopathic pulmonary fibrosis (IPF). IPF lung tissue, and lung fibroblasts treated with TGF-β, exhibit increased aerobic glycolysis with increased expression of lactate dehydrogenase A (LDHA) and excess production of lactate, leading to reduced extracellular pH that activates latent TGF-β. Here, we …

Epigenetic States Regulate Tumor Aggressiveness And Response To Targeted Therapies In Lung Adenocarcinoma, Fan Chen

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, 85% of which are lung adenocarcinomas (LUAD). Although molecular studies of NSCLC identified targetable mutations of some oncogenes including BRAF, EGFR and ALK, no targeted therapies exist for most cases. Cancer epigenetics is the study of epigenetic modifications, including histone modifications, that control gene expression in cancer. Recent advances have revealed numerous epigenetic abnormalities in human cancers, and targeting epigenetic regulators could be effective at reversing dysregulated epigenetic programs or driving sensitivity to other targeted therapies.

Inhibitors of the histone methyltransferase EZH2 have recently been approved as …

The Effect Of The Interaction Of Exercise Training And Isolation On The Serotonergic System Of App/Ps1 Mice, Bailey J. Dansby

Graduate Theses/Dissertations

Alzheimer’s disease (AD) is a complex neurodegenerative disease that is characterized by the deposition of amyloid beta (Ab) peptides and, consecutively, by a loss of memory and cognitive functions. The amyloid cascade hypothesis suggests that Ab deposition is the main pathogenic of AD. There is evidence that both changes in production and clearance of Ab may be involved in AD pathology. Past studies have shown that exercise training leads to an upregulation in proteins directly involved with Ab clearance. Chronic stress is thought to exacerbate AD pathology by increasing production of Ab. Studies have also demonstrated a link between serotonin …

New Insights On The Role Of The Mesenchymal-Hematopoietic Stem Cell Axis In Autologous And Allogeneic Hematopoiesis., Tatiana D. Zorina

College of Health Professions Faculty Papers

Cytoreductive protocols are integral both as conditioning regimens for bone marrow (BM) transplantation and as part of therapies for malignancies, but their associated comorbidities represent a long-standing clinical problem. In particular, they cause myeloablation that debilitates the physiological role of mesenchymal stem and precursor cells (MSPCs) in sustaining hematopoiesis. This review addresses the damaging impact of cytoreductive regimens on MSPCs. In addition, it discusses prospects for alleviating the resulting iatrogenic comorbidities. New insights into the structural and functional dynamics of hematopoietic stem cell (HSC) niches reveal the existence of "empty" niches and the ability of the donor-derived healthy HSCs to …

Kujdesi Infermieror Te Pacientët Me Artrit Reumatoid, Valbona Zeqiraj

Theses and Dissertations

Artriti reumatoid është një çrregullim inflamator, sistemik,kronik i cili kryesisht prek nyjet që janë të veshura me synovium. Karakterizohet tipikisht nga një përfshirje simetrike,herë pas here deformuar, poliartriti periferik. Për shkak se është një sëmundje sistemike, mundet gjithashtu ndikojnë në të gjithë trupin, duke përfshirë zemrën, mushkëritë dhe sytë.

Shkaku AR nuk njihet plotësisht. Ka të ngjarë që individët e ndjeshëm gjenetikisht të ekspozohen ndaj një antigjeni të panjohurduke rezultuar në vetë-stimulim të sistemit imunitar (autoimuniteti).

Përgjigja imune reagon në mënyrë të kryqëzuar me indin pritës (membranën synoviale) duke rezultuar në pezmatim të membranës sinoviale (sinovit).Kjo krijon hipertrofi sinoviale.

Ky …

Incorporation Of Feeding Functional Group Information Informs Explanatory Patterns Of Long-Term Population Changes In Fish Assemblages, Jason C. Doll, Stephen J. Jacquemin

Biological Sciences Faculty Publications

The objective of this study was to evaluate long term trends of fish taxa in southern Lake Michigan while incorporating their functional roles to improve our understanding of ecosystem level changes that have occurred in the system over time. The approach used here highlighted the ease of incorporating ecological mechanisms into population models so researchers can take full advantage of available long-term ecosystem information. Long term studies of fish assemblages can be used to inform changes in community structure resulting from perturbations to aquatic systems and understanding these changes in fish assemblages can be better contextualized by grouping species according …

Physician Knowledge, Attitudes, And Behaviors Towards Registered Dietitian Nutritionists, Amy Motley Jones

UNF Graduate Theses and Dissertations

Diet is increasingly linked with overall quality of life, and a healthy diet is now being considered one of the cornerstones of preventative care. Physicians rely on Registered Dietitian Nutritionists (RDNs) as most doctors lack the nutrition knowledge to properly treat their patients, especially during their residency. Little published information exists on the specific collaboration of RDNs and resident physicians. This study aimed to determine whether mentoring with an RDN increased physician nutrition knowledge, increased consults to RDNs, and whether physician attitudes improved regarding their understanding of the role of the RDN in healthcare. Knowledge or attitude alone are not …

Characterizing The Role Of Necroptosis Of Airway Epithelial Cells In The Immune Response To Respiratory Pathogens, Ashleigh Nichole Riegler

All ETDs from UAB

Necroptosis, a programmed form of lytic cell death, is initiated by various viral and bacterial pathogens through irreparable ion dysregulation and energy depletion. This cellular damage results in the activation of the cellular kinases RIPK1 and RIPK3, consecutively, and the activation and membrane targeting of MLKL, the latter responsible for lysis. Here we have demonstrated that necroptosis of airway epithelial cells is key in the development of the adaptive immune response to asymptomatic colonization by Streptococcus pneumoniae (Spn). Briefly, necroptotic deficient animals or wildtype animals colonized with Spn lacking the necroptosis-triggering pneumolysin toxin, failed to recruit CD11c+ leukocytes to the …

Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden

All ETDs from UAB

Human cytomegalovirus (HCMV) is a complex double stranded DNA betaherpesvirus. Its linear DNA in enclosed in an icosahedral capsid, and has a genome size of about 230kb and encodes about 170 genes. Primary infection with HCMV lead to a lifelong persistent infection. HCMV can also be transmitted across the placenta and infect the developing fetus leading to infection of the newborn infant, an infection which is commonly described as congenital HCMV infection. In the United States, the prevalence of congenital HCMV infection is between 0.2-1.2%. Approximately 5-15% of these newborn infants will develop long-term neurological damage resulting, motor disorder, cognition …

Tgfβ Provides The Backbone Of Embryogenesis: Elucidating The Role Of Tgfβ Signaling And Its Downstream Effectors On Spinal Column Development, Sade Williams Clayton

All ETDs from UAB

The spinal column is composed of two components, the vertebra (VB) that provide support and the intervertebral disc (IVD) that provide weight distribution. The structural integrity of IVDs is maintained by a fibrocartilaginous tissue called the annulus fibrosus (AF) which can degenerate with age or trauma and contribute to chronic back pain. There are currently no diseases modifying treatments that curb IVD degeneration. Regenerative therapies to treat IVD degeneration can be developed from identifying the signaling factors required for AF differentiation, but these factors are unknown. Previously, we showed that TGFβ signaling is required for AF formation in mice and …

Stress And Neuropeptide Y: Hippocampal Crossroads, Mariana Andrea Cortes

All ETDs from UAB

Anxiety disorders are the most common neuropsychiatric disorders diagnosed in adolescence and adulthood. While most animal models of trauma and stress-related disorders are performed in adults, and clinical trials for the treatment of these disorders typically include adult patients, there is a gap in knowledge for understanding how traumatic disorders develop in adolescence. Neuropeptide Y (NPY) is an endogenous peptide that provides anxiolytic benefits, and promotes feeding, arousal, and reduces inflammation. While being reduced in patients with depression and post-traumatic stress disorder (PTSD), animal models using NPY injections directly in to hippocampus have found it to be sufficient for blocking …

The Hocl Response Of Escherichia Coli., Rhea Marie Derke

All ETDs from UAB

Inflammatory bowel diseases (IBDs), like Chron’s disease and ulcerative colitis, affect millions of people worldwide. There are limited treatment options available for these diseases because their direct causes are unknown. IBDs are characterized by chronic inflammation of the gastrointestinal tract and changes in the composition of the gut microbiome. Enterobacteria, including Escherichia coli, bloom to high levels in the gut during inflammation and contribute to the pathology of IBDs. E. coli must tolerate high levels of antimicrobial compounds produced by the immune system to survive during persistent inflammation. A large proportion of such compounds are reactive oxygen and reactive chlorine …

Alternative Splicing Of Anxa7 Dictates Receptor Tyrosine Kinase Fates In Glioblastoma, Sindhu Nair

All ETDs from UAB

Alternative splicing (AS) is a tightly regulated process essential for lineage specification in complex tissues like the brain. Dysregulated splicing in glioblastoma (GBM) is a mechanism exploited by tumor cells to retain or splice out exons consequently rewiring isoform-specific protein interactions to sustain tumor phenotypes. Receptor tyrosine kinases (RTK) amplifications are frequent events in GBM driving tumor growth and progression and are key targets for chemotherapy. However, RTK targeting in GBM has achieved limited success predominantly due to adaptive mechanisms of resistance in a constantly evolving tumor microenvironment. Clonal populations and crosstalk between RTKs sustain heterogeneity within a tumor leading …

The Role Of Cd38 In Anti-Tumor Immunity And Tumor Immune Evasion, Panpan Yuan

All ETDs from UAB

CD38 is a multifunctional protein that is expressed in many immune cells, modulating NAD metabolism, inflammation and oxidative stress. Recent studies suggest that CD38 is also implicated in tumor immunosuppression. However, the role of CD38 in anti-tumor immunity and tumor immune evasion, and mechanisms involved, are still unclear. We hypothesized that CD38 expression by immune cells constricts T cell-mediated anti-tumor immune responses and promotes tumor cell immune evasion. We investigated whether mice lacking CD38 (CD38-/-) had impaired tumor growth in subcutaneous, intraperitoneal and intravenous syngeneic tumor models. CD38-/- mice showed no difference in subcutaneous B16 melanoma tumor growth and pulmonary …

Contribution Of The Human Microbiome And Proteus Mirabilis To Onset And Progression Of Rheumatoid Arthritis: Potential For Targeted Therapy, Jessica Kerpez, Marc Kesselman, Michelle Demory Beckler

Internet Journal of Allied Health Sciences and Practice

The human microbiome has been shown to play a role in the regulation of human health, behavior, and disease. Data suggests that microorganisms that co-evolved within humans have an enhanced ability to prevent the development of a large spectrum of immune-related disorders but may also lead to the onset of conditions when homeostasis is disrupted. In many conditions, a link between dysbiosis (microbial imbalance or microbiome upset) has been identified and associated with immune conditions such as rheumatoid arthritis (RA). This review provides insight into how an individual’s unique microbiome, combined with a genetic predisposition and environmental factors may lead …

Anti-Map Triple Therapy Supports Immunomodulatory Therapeutic Response In Crohn's Disease Through Downregulation Of Nf-Kb Activation In The Absence Of Map Detection, Erij Elkamel

Electronic Theses and Dissertations, 2020-2023

The triple antibiotic formulation, known as anti-MAP therapy, exhibits unique synergistic antimicrobial activity and should be effective for treatment of Crohn's disease (CD) associated with Mycobacterium avium subspecies paratuberculosis (MAP). The absence of MAP detection in some CD cases may be linked to poor diagnostics or lack of association with the disease. To understand the therapeutic response of some CD patients to anti-MAP therapy in absence of MAP detection, the immunomodulatory potency of anti-MAP therapy and its major ingredients, clarithromycin (CLA) and rifabutin (RIF), in THP-1, Caco-2, and Jurkat T-cells were investigated. Anti-MAP formulation at 2.0 µg/mL decreased MAP viability …

Reassessing The Transcriptional Regulation Of Protective Cd4 T Cell Responses Against Influenza A Virus, Kunal Dhume

Electronic Theses and Dissertations, 2020-2023

An attractive strategy to improve efficacy of current Influenza A Virus (IAV) vaccines is to promote protective CD4 T cell responses. Antiviral CD4 T cell responses are predominantly classified as strong IFN-gamma producing T helper type 1 (Th1) cells. Yet, the role of IFN-gamma in protection against IAV is still unclear, suggesting absolute Th1 polarization may be expendable for effective IAV immunity. Here we test this hypothesis using models that restrict the deficiency of known transcriptional regulators of Th1 immunity in only CD4 T cells, avoiding indirect impact on other immune cell responses. We find the 'master regulator' of Th1 …

Moderate Heat-Assisted Gene Electrotransfer As A Potential Delivery Approach For Protein Replacement Therapy Through The Skin, Chelsea Edelblute, Cathryn Mangiamele, Richard Heller

Bioelectrics Publications

Gene-based approaches for protein replacement therapies have the potential to reduce the number of administrations. Our previous work demonstrated that expression could be enhanced and/or the applied voltage reduced by preheating the tissue prior to pulse administration. In the current study, we utilized our 16-pin multi-electrode array (MEA) and incorporated nine optical fibers, connected to an infrared laser, between each set of four electrodes to heat the tissue to 43 °C. For proof of principle, a guinea pig model was used to test delivery of reporter genes. We observed that when the skin was preheated, it was possible to achieve …

Moderate Heat-Assisted Gene Electrotransfer For Cutaneous Delivery Of A Dna Vaccine Against Hepatitis B Virus, Chelsea Edelblute, Cathryn Mangiamele, Richard Heller

Bioelectrics Publications

An estimated 350 million people are living with chronic Hepatitis B virus (HBV) worldwide. Preventative HBV vaccination in infants has reduced the disease burden; however, insufficient immunization programs and access obstacles leave vulnerable populations at risk for infection in endemic regions. Gene electrotransfer (GET) using a noninvasive multielectrode array (MEA) provides an alternative platform for DNA vaccination in the skin. DNA vaccines are nonlive and nonreplicating and temperature stable unlike their counterparts. In addition, their simple engineering allows them to be manufactured quickly at a low cost. In the current work, we present the combination of GET and moderate heating …

Effect Of He Plasma Jet Versus Surface Plasma On The Metabolites Of Acute Myeloid Leukemia Cells, Dehui Xu, Ning Ning, Yujing Xu, Wenjie Xia, Hai-Lan Chen, Michael G. Kong

Bioelectrics Publications

Cold atmospheric plasma, including plasma jet and surface plasma, can promote the apoptosis of cancer cells without causing significant damage to surrounding normal cells, which was hopeful to be applied to the clinical cancer therapy. However, experimental plasma devices used directly to clinical experiments has challenges in technology and methods, especially the difference in killing tumor cells efficiency of these two common plasma sources. Therefore, it is great necessity to explore the differences in treating tumors between different plasma sources. This paper achieved good killing efficiency by using two kinds of cold atmospheric plasma generating devices, namely plasma jet and …

Role Of Mkp-2 In Hepatic Inflammatory Response To Fasting Mice, Sadie Junkins

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Utilities Value In Diabetic Retinopathy, Pear Pongsachareonnont Ferreira

Chulalongkorn University Theses and Dissertations (Chula ETD)

Health utilities has been used as weighted for a quality adjusted life year in health technology assessment. There are limited data on the utilites value in diabetic retinopathy and retina diseases in the South Asian region. The aim of this project are to estimate the visual health utility (HU) in patients with diabetic retinopathy (DR), age-related macular degeneration (AMD), and cataract. Moreover, we intended to evaluate an appropriate health utility instrument among a direct choice-based, traditional time trade-off (tTTO) and composite time trade-off (cTTO), and multiple attribute utility instrument (MAUI) ( EQ-VAS, European Quality of Life (QoL) Five Dimension (EQ-5D-5L), …

สัดส่วนการกลับเข้าทำงานและปัจจัยที่เกี่ยวข้องในแรงงานสูงอายุที่ได้รับบาดเจ็บในจังหวัดสมุทรปราการ, เพ็ญพิชญา วงษ์วิวัฒน์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยนี้เป็นการศึกษาวิจัยย้อนหลัง เพื่อศึกษาสัดส่วนการกลับเข้าทำงาน สัดส่วนการไม่สามารถกลับเข้าทำงาน และปัจจัยที่ส่งผลต่อการกลับเข้าทำงานในแรงงานสูงอายุ โดยเก็บข้อมูลทุติยภูมิจากแบบแจ้งการประสบอันตราย เจ็บป่วย หรือสูญหาย และคำร้องขอเงินทดแทน ตามพระราชบัญญัติเงินทดแทน พ.ศ. 2537 (กท.16) จากแบบคำร้องเงินทดแทนในช่วงเดือนมกราคมถึงเดือนธันวาคม พ.ศ. 2563 จังหวัดสมุทรปราการ ที่มีอายุ 50-80 ปี ได้กลุ่มตัวอย่างจริงทั้งหมด 433 คน ผลการศึกษาพบว่าส่วนใหญ่สามารถกลับเข้าทำงานได้ 432 คน (ร้อยละ 99.77) และไม่สามารถกลับเข้าทำงานได้ 1 คน (ร้อยละ 0.23) สามารถกลับเข้าทำงานได้โดยเฉลี่ยในเวลา 5 วัน (median survival time) และเมื่อทำการควบคุมอิทธิพลของตัวแปรอื่นๆ พบว่าปัจจัยที่มีความสัมพันธ์อย่างมีนัยทางสถิติกับการกลับเข้าทำงาน คือ รายได้ โดยกลุ่มที่มีรายได้ต่อเดือนมากที่สุด มีโอกาสการกลับเข้าทำงานเป็น 0.63 เท่า ของการกลับเข้าทำงานในกลุ่มที่มีรายได้น้อยที่สุด (HRadj=0.63; 95% CI: 0.45–0.89) และชนิดของการบาดเจ็บจากการมีแผลหรือการที่มีอวัยวะของร่างกายถูกตัดออก มีโอกาสกลับเข้าทำงานได้เป็น 2.78 เท่า ของกลุ่มที่มีการบาดเจ็บบริเวณศีรษะหรือเส้นประสาทหรือไขสันหลังหรือการบาดเจ็บหลายตำแหน่งหรือการบาดเจ็บชนิดอื่น (HRadj=2.78; 95% CI: 1.64–4.74) และตำแหน่งการได้รับบาดเจ็บบริเวณศีรษะหรือลำคอ มีโอกาสกลับเข้าทำงานได้เป็น 2.24 เท่าของบริเวณลำตัว (HRadj=2.24; 95% CI: 1.32–3.82) ในส่วนของอายุพบว่าอายุที่เพิ่มขึ้นทุก 1 ปี ส่งผลให้โอกาสกลับเข้าทำงานได้ลดลงร้อยละ 3.42 แต่กลับไม่พบความสัมพันธ์ของอายุกับการกลับเข้าทำงานเมื่อทำการวิเคราะห์เพิ่มเติม โดยสรุป ความรุนแรงของการบาดเจ็บที่ลดลงทำให้โอกาสการกลับเข้าทำงานมากขึ้น และไม่พบว่าอายุส่งผลต่อการกลับเข้าทำงานโดยตรง ดังนั้นควรทำการประเมินลักษณะงานให้เหมาะสมกับแรงงานสูงอายุ โดยหลีกเลี่ยงงานที่มีความเสี่ยงต่อการประสบอันตรายระดับรุนแรง

ความชุก อุบัติการณ์ และปัจจัยที่เกี่ยวข้องของโรคติดต่อทางเพศสัมพันธ์ ในกลุ่มพนักงานบริการทางเพศที่มารับบริการคัดกรองโรคที่ศูนย์พัทยารักษ์, พิชญา ชีวะสุทโธ

Chulalongkorn University Theses and Dissertations (Chula ETD)

ความเป็นมา ในปัจจุบันยังไม่มีการศึกษาเกี่ยวกับอัตราการป่วยด้วยโรคติดต่อทางเพศสัมพันธ์และปัจจัยที่เกี่ยวข้องในกลุ่มพนักงานบริการทางเพศซึ่งเป็นผู้สัมผัสปัจจัยเสี่ยงในการประกอบอาชีพ วัตถุประสงค์ เพื่อศึกษาความชุก อุบัติการณ์ และปัจจัยที่เกี่ยวข้องกับโรคติดต่อทางเพศสัมพันธ์ในกลุ่มพนักงานบริการทางเพศที่มารับบริการคัดกรองโรคที่ศูนย์พัทยารักษ์ วิธีการศึกษา การศึกษาชนิดภาคตัดขวาง (Cross-sectional study) และการศึกษาตามรุ่นย้อนหลัง (Retrospective cohort study) จากเวชระเบียนของศูนย์พัทยารักษ์ตั้งแต่ 1 มกราคม พ.ศ.2559 จนถึง 31 ธันวาคม พ.ศ.2563 กลุ่มตัวอย่างคือผู้ประกอบอาชีพพนักงานบริการทางเพศในเขตเมืองพัทยาที่มาเข้ารับบริการที่ศูนย์พัทยารักษ์ในช่วงเวลา 5 ปีของการติดตาม รวมทั้งหมด 2,588 คน เก็บข้อมูลด้วยแบบบันทึกข้อมูล นำมาวิเคราะห์ทางสถิติเชิงพรรณนาและวิเคราะห์ปัจจัยที่เกี่ยวข้อง โดยใช้ Poisson regression ด้วยโปรแกรม STATA Version 14.0 ผลการศึกษา พนักงานบริการทางเพศ 2,588 คน มีจำนวนการรับบริการทั้งหมด 21,819 ครั้ง โรคที่มีอัตราความชุกสูงที่สุดในพนักงานหญิงและชายคือโรคหูด (149.97 ครั้ง/1,000 ตัวอย่าง) และเอชไอวี (172.41 ครั้ง/1,000 ตัวอย่าง) ตามลำดับ และโรคที่มีอัตราอุบัติการณ์สูงที่สุดในพนักงานหญิงและชายคือโรคหูด (4.84 ราย/1,000 บุคคล-เดือน) และซิฟิลิส (154.93 ราย/1,000 บุคคล-เดือน) ตามลำดับ เมื่อวิเคราะห์แบบ Adjusted analysis พบว่าปัจจัยที่มีความสัมพันธ์กับโรคติดต่อทางเพศสัมพันธ์บางโรค อย่างมีนัยสำคัญทางสถิติ ได้แก่ พฤติกรรมเสี่ยงคือการมีเพศสัมพันธ์กับผู้ใช้บริการทางเพศโดยไม่ใช้ถุงยางอนามัย, การมีคู่เพศสัมพันธ์คนใหม่, การมีเพศสัมพันธ์แล้วถุงยางอนามัยแตก รั่ว หลุด สรุป การส่งเสริมการใช้ถุงยางอนามัยให้เหมาะสมและการให้ความรู้เกี่ยวกับโรคติดต่อทางเพศสัมพันธ์จะสามารถลดขนาดปัญหาโรคติดต่อทางเพศสัมพันธ์บางโรค (เช่น โรคหนองในแท้ โรคหูด โรคเริม โรคพยาธิช่องคลอด) ในกลุ่มพนักงานบริการทางเพศ

The Role Of Neutrophils Against Pythium Insidiosum, Apichaya Sriwarom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pythium insidiosum (P. insidiosum) is an oomycetes fungus-like microorganism causing pythiosis infection in humans. The zoospores (infective stage) of this pathogen contaminate aquatic environments such as moist soil and swampy area, which is a natural habitiat. Humans are infected with P. insidiosum via cutaneous route which is the main entry of the zoospores. Recent studies have shown that patients with pythiosis shows high morbidity and mortality rates particularly those with hematologic diseases. As neutrophils are the first line of immune defense during fungal infections, this study therefore investigated the activity of neutrophils in response to P. insidiosum. The neutrophil killing …

Alteration Of Extracellular Matrix Components In Anterior Pituitary Gland Of Neonatal Rats Induced By Maternal Bisphenol A (Bpa) Diet During Pregnancy, Bumpenporn Sanannam

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bisphenol A (BPA) is a well-known endocrine-disrupting chemical that is widely used in the resin and plastic manufacturing sectors. Prenatal exposure to this chemical results in changes of pituitary hormone-producing cells. However, there have been no reports of the alterations of extracellular matrix (ECM) which play a role in controlling cell activities in the pituitary gland. In the present study, a daily oral dose of 5,000 µg/kg BW of BPA was administered to pregnant rats. ECM-producing cells, i.e., pericytes and folliculostelate cells, ECM products, and ECM regulators were investigated in the neonatal anterior pituitary at day 1 at the histology …

A Novel Review Of Heat Shock Protein 110 Kda: A Basis For Research And Continued Experimentation Through Biochemical Analysis, Crist W. Cuffee

Theses and Dissertations

Heat shock protein 110 kDa, Hsp110, is a distinct cellular protector, different in form and function from Hsp70, a close relative of Hsp110. Functioning primarily as a holdase or in tandem with other molecular chaperones, a review of current accomplishments elucidates the uniqueness of this protein and the continued mysteries that surrounds it. Found only in eukaryotes, Hsp110 has been linked to many diseases, ranging from parasitic infection to neurodegenerative disorders. While still lacking, studies of this protein have provided much in the realm of speculation on the mechanisms behind Hsp110s’ contribution to different pathologies. This review will serve as …

Stunting And Combined Overweight With Stunting Among Schoolchildren In Kuwait: Trends Over A 13-Year Period, Abdullah Al-Taiar, Nawal Alqaoud, Reem Sharaf Alddin, Faheema Alanezi, Monica Subhakaran, Anne Dumadag, Ahmed N. Albatineh

Community & Environmental Health Faculty Publications

Objectives: This study aimed to investigate the sex- and age-specific trends of stunting and combined overweight with stunting among schoolchildren over a 13-year period in Kuwait. Subjects and Methods: The Kuwait Nutrition Surveillance System objectively measured the height of 172,573 schoolchildren (5–19 years) over a 13-year period (2007–2019). Data on gender and date of birth were extracted from school records. Stunting was defined as height 2 standard deviations (SD) below the World Health Organization growth reference median. Logistic regression models were used to examine the trends of stunting over the study period while stratifying by gender. Results: In males, the …

Is Sexuality A Choice? An Analysis Of The Facts And Factors That Influence One’S Sexual Orientation, Brandon Scott Hodges

PCOM Capstone Projects

Sexual orientation is often viewed as the sex or gender to which one is attracted to; however, it is not that simple. Also, though many believe the default is for one to be attracted to the opposite sex and any other claim of sexual attraction is a choice; that is not true. Sexual orientation is the result of a complex combination of one’s genes, environment, and hormones. As a result, not only is sexuality not a choice, but just as there are so many different colors, there are so many different sexual orientations beyond heterosexual, such as homosexual, bisexual, and …

Vertebrate Subfossil Localities In Taylorsville Metropark, Montgomery County, Ohio, Usa, Ryan Shell, Kristin Zimmerman, David Peterman, Charles Ciampaglio, Lauren Fuelling, Stephen J. Jacquemin

Biological Sciences Faculty Publications

Karst features in the Silurian dolomites of Taylorsville MetroPark (Dayton Metropolitan Area, Ohio, United States) were explored from 2017 to 2018 to identify sites of paleontological interest. Initial landscape surveys recovered 124 skeletal elements (from 12 sites) that were attributed to 17 vertebrate species--including evidence of such extirpated animals as bobcats (Lynx rufus) and rattlesnakes (Crotalus sp.). Of the 12 sites, 9 sites contained remains from the historical era and 3 sites contained much older remains (n = 17) that were radiocarbon dated to approximately 1,400 years before present (YBP). Human remains at one site, butchered bones at another, and …