Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Medical Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 14461 - 14490 of 24298

Full-Text Articles in Entire DC Network

Moderate Heat-Assisted Gene Electrotransfer For Cutaneous Delivery Of A Dna Vaccine Against Hepatitis B Virus, Chelsea Edelblute, Cathryn Mangiamele, Richard Heller Jan 2021

Moderate Heat-Assisted Gene Electrotransfer For Cutaneous Delivery Of A Dna Vaccine Against Hepatitis B Virus, Chelsea Edelblute, Cathryn Mangiamele, Richard Heller

Bioelectrics Publications

An estimated 350 million people are living with chronic Hepatitis B virus (HBV) worldwide. Preventative HBV vaccination in infants has reduced the disease burden; however, insufficient immunization programs and access obstacles leave vulnerable populations at risk for infection in endemic regions. Gene electrotransfer (GET) using a noninvasive multielectrode array (MEA) provides an alternative platform for DNA vaccination in the skin. DNA vaccines are nonlive and nonreplicating and temperature stable unlike their counterparts. In addition, their simple engineering allows them to be manufactured quickly at a low cost. In the current work, we present the combination of GET and moderate heating …

Go to article

Effect Of He Plasma Jet Versus Surface Plasma On The Metabolites Of Acute Myeloid Leukemia Cells, Dehui Xu, Ning Ning, Yujing Xu, Wenjie Xia, Hai-Lan Chen, Michael G. Kong Jan 2021

Effect Of He Plasma Jet Versus Surface Plasma On The Metabolites Of Acute Myeloid Leukemia Cells, Dehui Xu, Ning Ning, Yujing Xu, Wenjie Xia, Hai-Lan Chen, Michael G. Kong

Bioelectrics Publications

Cold atmospheric plasma, including plasma jet and surface plasma, can promote the apoptosis of cancer cells without causing significant damage to surrounding normal cells, which was hopeful to be applied to the clinical cancer therapy. However, experimental plasma devices used directly to clinical experiments has challenges in technology and methods, especially the difference in killing tumor cells efficiency of these two common plasma sources. Therefore, it is great necessity to explore the differences in treating tumors between different plasma sources. This paper achieved good killing efficiency by using two kinds of cold atmospheric plasma generating devices, namely plasma jet and …

Go to article

Role Of Mkp-2 In Hepatic Inflammatory Response To Fasting Mice, Sadie Junkins Jan 2021

Role Of Mkp-2 In Hepatic Inflammatory Response To Fasting Mice, Sadie Junkins

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Go to article

Utilities Value In Diabetic Retinopathy, Pear Pongsachareonnont Ferreira Jan 2021

Utilities Value In Diabetic Retinopathy, Pear Pongsachareonnont Ferreira

Chulalongkorn University Theses and Dissertations (Chula ETD)

Health utilities has been used as weighted for a quality adjusted life year in health technology assessment. There are limited data on the utilites value in diabetic retinopathy and retina diseases in the South Asian region. The aim of this project are to estimate the visual health utility (HU) in patients with diabetic retinopathy (DR), age-related macular degeneration (AMD), and cataract. Moreover, we intended to evaluate an appropriate health utility instrument among a direct choice-based, traditional time trade-off (tTTO) and composite time trade-off (cTTO), and multiple attribute utility instrument (MAUI) ( EQ-VAS, European Quality of Life (QoL) Five Dimension (EQ-5D-5L), …

Go to article

สัดส่วนการกลับเข้าทำงานและปัจจัยที่เกี่ยวข้องในแรงงานสูงอายุที่ได้รับบาดเจ็บในจังหวัดสมุทรปราการ, เพ็ญพิชญา วงษ์วิวัฒน์ Jan 2021

สัดส่วนการกลับเข้าทำงานและปัจจัยที่เกี่ยวข้องในแรงงานสูงอายุที่ได้รับบาดเจ็บในจังหวัดสมุทรปราการ, เพ็ญพิชญา วงษ์วิวัฒน์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยนี้เป็นการศึกษาวิจัยย้อนหลัง เพื่อศึกษาสัดส่วนการกลับเข้าทำงาน สัดส่วนการไม่สามารถกลับเข้าทำงาน และปัจจัยที่ส่งผลต่อการกลับเข้าทำงานในแรงงานสูงอายุ โดยเก็บข้อมูลทุติยภูมิจากแบบแจ้งการประสบอันตราย เจ็บป่วย หรือสูญหาย และคำร้องขอเงินทดแทน ตามพระราชบัญญัติเงินทดแทน พ.ศ. 2537 (กท.16) จากแบบคำร้องเงินทดแทนในช่วงเดือนมกราคมถึงเดือนธันวาคม พ.ศ. 2563 จังหวัดสมุทรปราการ ที่มีอายุ 50-80 ปี ได้กลุ่มตัวอย่างจริงทั้งหมด 433 คน ผลการศึกษาพบว่าส่วนใหญ่สามารถกลับเข้าทำงานได้ 432 คน (ร้อยละ 99.77) และไม่สามารถกลับเข้าทำงานได้ 1 คน (ร้อยละ 0.23) สามารถกลับเข้าทำงานได้โดยเฉลี่ยในเวลา 5 วัน (median survival time) และเมื่อทำการควบคุมอิทธิพลของตัวแปรอื่นๆ พบว่าปัจจัยที่มีความสัมพันธ์อย่างมีนัยทางสถิติกับการกลับเข้าทำงาน คือ รายได้ โดยกลุ่มที่มีรายได้ต่อเดือนมากที่สุด มีโอกาสการกลับเข้าทำงานเป็น 0.63 เท่า ของการกลับเข้าทำงานในกลุ่มที่มีรายได้น้อยที่สุด (HRadj=0.63; 95% CI: 0.45–0.89) และชนิดของการบาดเจ็บจากการมีแผลหรือการที่มีอวัยวะของร่างกายถูกตัดออก มีโอกาสกลับเข้าทำงานได้เป็น 2.78 เท่า ของกลุ่มที่มีการบาดเจ็บบริเวณศีรษะหรือเส้นประสาทหรือไขสันหลังหรือการบาดเจ็บหลายตำแหน่งหรือการบาดเจ็บชนิดอื่น (HRadj=2.78; 95% CI: 1.64–4.74) และตำแหน่งการได้รับบาดเจ็บบริเวณศีรษะหรือลำคอ มีโอกาสกลับเข้าทำงานได้เป็น 2.24 เท่าของบริเวณลำตัว (HRadj=2.24; 95% CI: 1.32–3.82) ในส่วนของอายุพบว่าอายุที่เพิ่มขึ้นทุก 1 ปี ส่งผลให้โอกาสกลับเข้าทำงานได้ลดลงร้อยละ 3.42 แต่กลับไม่พบความสัมพันธ์ของอายุกับการกลับเข้าทำงานเมื่อทำการวิเคราะห์เพิ่มเติม โดยสรุป ความรุนแรงของการบาดเจ็บที่ลดลงทำให้โอกาสการกลับเข้าทำงานมากขึ้น และไม่พบว่าอายุส่งผลต่อการกลับเข้าทำงานโดยตรง ดังนั้นควรทำการประเมินลักษณะงานให้เหมาะสมกับแรงงานสูงอายุ โดยหลีกเลี่ยงงานที่มีความเสี่ยงต่อการประสบอันตรายระดับรุนแรง

Go to article

ความชุก อุบัติการณ์ และปัจจัยที่เกี่ยวข้องของโรคติดต่อทางเพศสัมพันธ์ ในกลุ่มพนักงานบริการทางเพศที่มารับบริการคัดกรองโรคที่ศูนย์พัทยารักษ์, พิชญา ชีวะสุทโธ Jan 2021

ความชุก อุบัติการณ์ และปัจจัยที่เกี่ยวข้องของโรคติดต่อทางเพศสัมพันธ์ ในกลุ่มพนักงานบริการทางเพศที่มารับบริการคัดกรองโรคที่ศูนย์พัทยารักษ์, พิชญา ชีวะสุทโธ

Chulalongkorn University Theses and Dissertations (Chula ETD)

ความเป็นมา ในปัจจุบันยังไม่มีการศึกษาเกี่ยวกับอัตราการป่วยด้วยโรคติดต่อทางเพศสัมพันธ์และปัจจัยที่เกี่ยวข้องในกลุ่มพนักงานบริการทางเพศซึ่งเป็นผู้สัมผัสปัจจัยเสี่ยงในการประกอบอาชีพ วัตถุประสงค์ เพื่อศึกษาความชุก อุบัติการณ์ และปัจจัยที่เกี่ยวข้องกับโรคติดต่อทางเพศสัมพันธ์ในกลุ่มพนักงานบริการทางเพศที่มารับบริการคัดกรองโรคที่ศูนย์พัทยารักษ์ วิธีการศึกษา การศึกษาชนิดภาคตัดขวาง (Cross-sectional study) และการศึกษาตามรุ่นย้อนหลัง (Retrospective cohort study) จากเวชระเบียนของศูนย์พัทยารักษ์ตั้งแต่ 1 มกราคม พ.ศ.2559 จนถึง 31 ธันวาคม พ.ศ.2563 กลุ่มตัวอย่างคือผู้ประกอบอาชีพพนักงานบริการทางเพศในเขตเมืองพัทยาที่มาเข้ารับบริการที่ศูนย์พัทยารักษ์ในช่วงเวลา 5 ปีของการติดตาม รวมทั้งหมด 2,588 คน เก็บข้อมูลด้วยแบบบันทึกข้อมูล นำมาวิเคราะห์ทางสถิติเชิงพรรณนาและวิเคราะห์ปัจจัยที่เกี่ยวข้อง โดยใช้ Poisson regression ด้วยโปรแกรม STATA Version 14.0 ผลการศึกษา พนักงานบริการทางเพศ 2,588 คน มีจำนวนการรับบริการทั้งหมด 21,819 ครั้ง โรคที่มีอัตราความชุกสูงที่สุดในพนักงานหญิงและชายคือโรคหูด (149.97 ครั้ง/1,000 ตัวอย่าง) และเอชไอวี (172.41 ครั้ง/1,000 ตัวอย่าง) ตามลำดับ และโรคที่มีอัตราอุบัติการณ์สูงที่สุดในพนักงานหญิงและชายคือโรคหูด (4.84 ราย/1,000 บุคคล-เดือน) และซิฟิลิส (154.93 ราย/1,000 บุคคล-เดือน) ตามลำดับ เมื่อวิเคราะห์แบบ Adjusted analysis พบว่าปัจจัยที่มีความสัมพันธ์กับโรคติดต่อทางเพศสัมพันธ์บางโรค อย่างมีนัยสำคัญทางสถิติ ได้แก่ พฤติกรรมเสี่ยงคือการมีเพศสัมพันธ์กับผู้ใช้บริการทางเพศโดยไม่ใช้ถุงยางอนามัย, การมีคู่เพศสัมพันธ์คนใหม่, การมีเพศสัมพันธ์แล้วถุงยางอนามัยแตก รั่ว หลุด สรุป การส่งเสริมการใช้ถุงยางอนามัยให้เหมาะสมและการให้ความรู้เกี่ยวกับโรคติดต่อทางเพศสัมพันธ์จะสามารถลดขนาดปัญหาโรคติดต่อทางเพศสัมพันธ์บางโรค (เช่น โรคหนองในแท้ โรคหูด โรคเริม โรคพยาธิช่องคลอด) ในกลุ่มพนักงานบริการทางเพศ

Go to article

The Role Of Neutrophils Against Pythium Insidiosum, Apichaya Sriwarom Jan 2021

The Role Of Neutrophils Against Pythium Insidiosum, Apichaya Sriwarom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pythium insidiosum (P. insidiosum) is an oomycetes fungus-like microorganism causing pythiosis infection in humans. The zoospores (infective stage) of this pathogen contaminate aquatic environments such as moist soil and swampy area, which is a natural habitiat. Humans are infected with P. insidiosum via cutaneous route which is the main entry of the zoospores. Recent studies have shown that patients with pythiosis shows high morbidity and mortality rates particularly those with hematologic diseases. As neutrophils are the first line of immune defense during fungal infections, this study therefore investigated the activity of neutrophils in response to P. insidiosum. The neutrophil killing …

Go to article

Alteration Of Extracellular Matrix Components In Anterior Pituitary Gland Of Neonatal Rats Induced By Maternal Bisphenol A (Bpa) Diet During Pregnancy, Bumpenporn Sanannam Jan 2021

Alteration Of Extracellular Matrix Components In Anterior Pituitary Gland Of Neonatal Rats Induced By Maternal Bisphenol A (Bpa) Diet During Pregnancy, Bumpenporn Sanannam

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bisphenol A (BPA) is a well-known endocrine-disrupting chemical that is widely used in the resin and plastic manufacturing sectors. Prenatal exposure to this chemical results in changes of pituitary hormone-producing cells. However, there have been no reports of the alterations of extracellular matrix (ECM) which play a role in controlling cell activities in the pituitary gland. In the present study, a daily oral dose of 5,000 µg/kg BW of BPA was administered to pregnant rats. ECM-producing cells, i.e., pericytes and folliculostelate cells, ECM products, and ECM regulators were investigated in the neonatal anterior pituitary at day 1 at the histology …

Go to article

A Novel Review Of Heat Shock Protein 110 Kda: A Basis For Research And Continued Experimentation Through Biochemical Analysis, Crist W. Cuffee Jan 2021

A Novel Review Of Heat Shock Protein 110 Kda: A Basis For Research And Continued Experimentation Through Biochemical Analysis, Crist W. Cuffee

Theses and Dissertations

Heat shock protein 110 kDa, Hsp110, is a distinct cellular protector, different in form and function from Hsp70, a close relative of Hsp110. Functioning primarily as a holdase or in tandem with other molecular chaperones, a review of current accomplishments elucidates the uniqueness of this protein and the continued mysteries that surrounds it. Found only in eukaryotes, Hsp110 has been linked to many diseases, ranging from parasitic infection to neurodegenerative disorders. While still lacking, studies of this protein have provided much in the realm of speculation on the mechanisms behind Hsp110s’ contribution to different pathologies. This review will serve as …

Go to article

Stunting And Combined Overweight With Stunting Among Schoolchildren In Kuwait: Trends Over A 13-Year Period, Abdullah Al-Taiar, Nawal Alqaoud, Reem Sharaf Alddin, Faheema Alanezi, Monica Subhakaran, Anne Dumadag, Ahmed N. Albatineh Jan 2021

Stunting And Combined Overweight With Stunting Among Schoolchildren In Kuwait: Trends Over A 13-Year Period, Abdullah Al-Taiar, Nawal Alqaoud, Reem Sharaf Alddin, Faheema Alanezi, Monica Subhakaran, Anne Dumadag, Ahmed N. Albatineh

Community & Environmental Health Faculty Publications

Objectives: This study aimed to investigate the sex- and age-specific trends of stunting and combined overweight with stunting among schoolchildren over a 13-year period in Kuwait. Subjects and Methods: The Kuwait Nutrition Surveillance System objectively measured the height of 172,573 schoolchildren (5–19 years) over a 13-year period (2007–2019). Data on gender and date of birth were extracted from school records. Stunting was defined as height 2 standard deviations (SD) below the World Health Organization growth reference median. Logistic regression models were used to examine the trends of stunting over the study period while stratifying by gender. Results: In males, the …

Go to article

Is Sexuality A Choice? An Analysis Of The Facts And Factors That Influence One’S Sexual Orientation, Brandon Scott Hodges Jan 2021

Is Sexuality A Choice? An Analysis Of The Facts And Factors That Influence One’S Sexual Orientation, Brandon Scott Hodges

PCOM Capstone Projects

Sexual orientation is often viewed as the sex or gender to which one is attracted to; however, it is not that simple. Also, though many believe the default is for one to be attracted to the opposite sex and any other claim of sexual attraction is a choice; that is not true. Sexual orientation is the result of a complex combination of one’s genes, environment, and hormones. As a result, not only is sexuality not a choice, but just as there are so many different colors, there are so many different sexual orientations beyond heterosexual, such as homosexual, bisexual, and …

Go to article

Vertebrate Subfossil Localities In Taylorsville Metropark, Montgomery County, Ohio, Usa, Ryan Shell, Kristin Zimmerman, David Peterman, Charles Ciampaglio, Lauren Fuelling, Stephen J. Jacquemin Jan 2021

Vertebrate Subfossil Localities In Taylorsville Metropark, Montgomery County, Ohio, Usa, Ryan Shell, Kristin Zimmerman, David Peterman, Charles Ciampaglio, Lauren Fuelling, Stephen J. Jacquemin

Biological Sciences Faculty Publications

Karst features in the Silurian dolomites of Taylorsville MetroPark (Dayton Metropolitan Area, Ohio, United States) were explored from 2017 to 2018 to identify sites of paleontological interest. Initial landscape surveys recovered 124 skeletal elements (from 12 sites) that were attributed to 17 vertebrate species--including evidence of such extirpated animals as bobcats (Lynx rufus) and rattlesnakes (Crotalus sp.). Of the 12 sites, 9 sites contained remains from the historical era and 3 sites contained much older remains (n = 17) that were radiocarbon dated to approximately 1,400 years before present (YBP). Human remains at one site, butchered bones at another, and …

Go to article

Evaluating Winter Malting Barley Grain Yield With Fractional Green Canopy Cover, Gregory J. Mcglinch, Stephen J. Jacquemin, Laura E. Lindsey Jan 2021

Evaluating Winter Malting Barley Grain Yield With Fractional Green Canopy Cover, Gregory J. Mcglinch, Stephen J. Jacquemin, Laura E. Lindsey

Biological Sciences Faculty Publications

Because of growth in the craft brewing industry, farmers in the eastern United States are planting winter malting barley (Hordeum vulgare L.) to meet demands for locally sourced grain. However, given that barley is a relatively new crop in this region, basic agronomic information relating to stand assessment is needed. This is particularly relevant in this region, as climatic variability from extreme temperature fluctuations during the winter and spring can reduce a barley stand, creating the need for farmers to estimate grain yield potential. The objective of the research was to evaluate the relationship between spring stem counts, fractional …

Go to article

Importance Of Fossil And Archaeological Occurrence Data For Understanding The Evolution And Distribution Of The Freshwater Drum (A. Grunniens)., Stephen J. Jacquemin, Lauren J. Fuelling, G. Stringer, A. Smith, Charles N. Ciampaglio Jan 2021

Importance Of Fossil And Archaeological Occurrence Data For Understanding The Evolution And Distribution Of The Freshwater Drum (A. Grunniens)., Stephen J. Jacquemin, Lauren J. Fuelling, G. Stringer, A. Smith, Charles N. Ciampaglio

Biological Sciences Faculty Publications

No abstract provided.

Go to article

Importance And Challenges Of Monitoring Harmful Algal Blooms In Grand Lake St Marys, Stephen J. Jacquemin, M. Morden, C. Ewing, J. C. Doll Jan 2021

Importance And Challenges Of Monitoring Harmful Algal Blooms In Grand Lake St Marys, Stephen J. Jacquemin, M. Morden, C. Ewing, J. C. Doll

Biological Sciences Faculty Publications

No abstract provided.

Go to article

The Current Landscape Of Antibody-Based Therapies In Solid Malignancies, Ashu Shah, Sanchita Rauth, Abhijit Aithal, Sukhwinder Kaur, Koelina Ganguly, Catherine Orzechowski, Grish C. Varshney, Maneesh Jain, Surinder K. Batra Jan 2021

The Current Landscape Of Antibody-Based Therapies In Solid Malignancies, Ashu Shah, Sanchita Rauth, Abhijit Aithal, Sukhwinder Kaur, Koelina Ganguly, Catherine Orzechowski, Grish C. Varshney, Maneesh Jain, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

Over the past three decades, monoclonal antibodies (mAbs) have revolutionized the landscape of cancer therapy. Still, this benefit remains restricted to a small proportion of patients due to moderate response rates and resistance emergence. The field has started to embrace better mAb-based formats with advancements in molecular and protein engineering technologies. The development of a therapeutic mAb with long-lasting clinical impact demands a prodigious understanding of target antigen, effective mechanism of action, gene engineering technologies, complex interplay between tumor and host immune system, and biomarkers for prediction of clinical response. This review discusses the various approaches used by mAbs for …

Go to article

Dynamic Phenotypic Switching And Group Behavior Help Non-Small Cell Lung Cancer Cells Evade Chemotherapy, Arin Nam, Atish Mohanty, Supriyo Bhattacharya, Sourabh Kotnala, Srisairam Achuthan, Kishore Hari, Saumya Srivastava, Linlin Guo, Anusha Nathan, Rishov Chatterjee, Maneesh Jain, Mohd W. Nasser, Surinder K. Batra, Govindan Rangarajan, Erminia Massarelli, Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia Jan 2021

Dynamic Phenotypic Switching And Group Behavior Help Non-Small Cell Lung Cancer Cells Evade Chemotherapy, Arin Nam, Atish Mohanty, Supriyo Bhattacharya, Sourabh Kotnala, Srisairam Achuthan, Kishore Hari, Saumya Srivastava, Linlin Guo, Anusha Nathan, Rishov Chatterjee, Maneesh Jain, Mohd W. Nasser, Surinder K. Batra, Govindan Rangarajan, Erminia Massarelli, Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia

Journal Articles: Biochemistry & Molecular Biology

Drug resistance, a major challenge in cancer therapy, is typically attributed to mutations and genetic heterogeneity. Emerging evidence suggests that dynamic cellular interactions and group behavior also contribute to drug resistance. However, the underlying mechanisms remain poorly understood. Here, we present a new mathematical approach with game theoretical underpinnings that we developed to model real-time growth data of non-small cell lung cancer (NSCLC) cells and discern patterns in response to treatment with cisplatin. We show that the cisplatin-sensitive and cisplatin-tolerant NSCLC cells, when co-cultured in the absence or presence of the drug, display dynamic group behavior strategies. Tolerant cells exhibit …

Go to article

Value Of Strain-Wave Sonoelastography As An Imaging Modality In Assessment Ofbenign Acute Myositis In Children, Ayşe Seçi̇l Ekşi̇oğlu, Ayla Akca Çağlar, Seda Kaynak Şahap, Can Demi̇r Karacan, Ni̇lden Tuygun Jan 2021

Value Of Strain-Wave Sonoelastography As An Imaging Modality In Assessment Ofbenign Acute Myositis In Children, Ayşe Seçi̇l Ekşi̇oğlu, Ayla Akca Çağlar, Seda Kaynak Şahap, Can Demi̇r Karacan, Ni̇lden Tuygun

Turkish Journal of Medical Sciences

Background/aim: Although sonoelastography is applied in assessment of many organs, studies for evaluation of muscles are very few in number and are mostly limited to adults. With this prospective study, we aimed to evaluate the value of sonoelastography in assessment of influenza related benign acute myositis in children. Materials and methods: This study enrolled 25 patients with a clinical diagnosis of benign acute childhood myositis (BACM) and 25 age and sex-matched healthy controls. All patients presented to our emergency department with the complaint of inability to walk and had increased serum creatine kinase (CK) levels. All patients underwent strain elastography …

Go to article

Evaluation Of The Effects Of Locally Applied Rosuvastatin On Bone Formation In A Threedimensional Reconstruction Rabbit Xenograft Model, Taha Özer, Alper Aktaş, Canseda Avağ, Ayşegül Firat, Mert Ocak, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k Jan 2021

Evaluation Of The Effects Of Locally Applied Rosuvastatin On Bone Formation In A Threedimensional Reconstruction Rabbit Xenograft Model, Taha Özer, Alper Aktaş, Canseda Avağ, Ayşegül Firat, Mert Ocak, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: Guided bone regeneration (GBR) is commonly performed to repair bone defects, and rigid occlusive titanium barriers play a vital role in bone formation in regions with no prior bone tissue. The statin, rosuvastatin (RSV), strongly affects bone apposition when applied locally. Here, we aimed to evaluate the anabolic effects of locally applied RSV with a xenograft placed on rabbit calvaria. Materials and methods: Two rigid occlusive titanium caps were used in 16 rabbits after decorticating the calvarial bone. In the control group, the area under the cap was filled with a xenograft, while in the RSV group, a xenograft …

Go to article

Perspectives For Immune Plasma Treatment Of Covid-19, Başak Sayinalp, Olgu Erki̇n Çinar, İbrahi̇m Celaletti̇n Haznedaroğlu Jan 2021

Perspectives For Immune Plasma Treatment Of Covid-19, Başak Sayinalp, Olgu Erki̇n Çinar, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Background/aim: The SARS-CoV-2 infection was declared as a pandemic by the World Health Organization (WHO) on March 11, 2020, and the death toll from COVID-19, which is the disease caused by SARS-CoV-2, has already surpassed that of many previous epidemics. A wide variety of treatment options are being considered for COVID-19, but there is still no definitive treatment or vaccine. This study aims to explain the background of convalescent plasma (CP) treatment and its relations with COVID-19 immunity, to define ideal treatment procedures, and to reveal present and future perspectives in the light of the rapidly growing data. Immunological basis …

Go to article

Magnetic Resonance Imaging Histogram Analysis Of Corpus Callosum In A Functionalneurological Disorder, Sema Baykara, Murat Baykara, Osman Mermi̇, Hanefi̇ Yildirim, Murad Atmaca Jan 2021

Magnetic Resonance Imaging Histogram Analysis Of Corpus Callosum In A Functionalneurological Disorder, Sema Baykara, Murat Baykara, Osman Mermi̇, Hanefi̇ Yildirim, Murad Atmaca

Turkish Journal of Medical Sciences

Background/aim: The aim of the present study was to examine and compare the corpus callosum (CC) via histogram analysis (HA) on T1-weighted MR images of patients diagnosed with Functional Neurological Disorder (FND) and healthy controls. Materials and methods: The study group included 19 female patients diagnosed with FND, and the control group included 20 healthy subjects. All participants were scanned with a 1.5 T MR scanner. A high-resolution structural image of the entire brain was obtained with sagittal 3D spiral fast spin echo T1-weighted images. Gray level intensity, standard deviation of the histogram, entropy, uniformity, skewness, and kurtosis values were …

Go to article

Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre Jan 2021

Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 outbreak is known to increase stress levels of most patients with chronic diseases. Patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are highly susceptible to environmental stress. In the current study, we aimed to determine how the COVID-19 pandemic psychologically affected patients with chronic progressive diseases such as AS and RA and the effects of these psychological factors on disease activity. Materials and methods: Age and sex-matched patients with AS (n = 80), RA (n = 80), and healthy controls (n = 80) were included in the study. All participants were evaluated with the "Perceived COVID-19 …

Go to article

Role Of Frailty In Prediction Of Hospitalized Older Adult Patient's Outcomes: A Prospective Study, Maryam Chehrehgosha, Reza Fadaye Vatan, Mahtab Alizadeh Khoei, Farshad Sharifi, Reyhaneh Aminalroaya, Zahra Vahabi, Abolfazl Zendedel, Hamidreza Hekmat Jan 2021

Role Of Frailty In Prediction Of Hospitalized Older Adult Patient's Outcomes: A Prospective Study, Maryam Chehrehgosha, Reza Fadaye Vatan, Mahtab Alizadeh Khoei, Farshad Sharifi, Reyhaneh Aminalroaya, Zahra Vahabi, Abolfazl Zendedel, Hamidreza Hekmat

Turkish Journal of Medical Sciences

Background/aim: Frailty is associated with an increased risk of negative short-term and long-term hospital outcomes. This study aimed to evaluate the role of frailty in predicting readmission, length of stay, and quality of life in the hospitalized older adults. Materials and methods: This observational study was conducted at Ziaiyan Hospital, Tehran, Iran. In total, 304 participants (65-85 years), were enrolled through the inclusion criteria from August to December 2019. The frailty index (FI) was assessed by the minimum data set-home care. Readmission was obtained through telephone interviews. The length of stay was gathered by the patient's hospital records, and the …

Go to article

The Psychological, Social, And Bioinformatic Considerations For The Return Of Continental Genetic Ancestry Estimates And Other Secondary Sequencing Results, Jaimie Leighan Richards Jan 2021

The Psychological, Social, And Bioinformatic Considerations For The Return Of Continental Genetic Ancestry Estimates And Other Secondary Sequencing Results, Jaimie Leighan Richards

All ETDs from UAB

With recent advances in sequencing technologies, large scale genome wide sequencing has advanced our understanding of disease risk and etiology. These tests, however, often provide secondary data beyond the scope of the original sequencing objectives, and our understanding of how and if participants want to receive these secondary results is important as clinical and research-based sequencing becomes commonplace. To address this, we completed a systematic review of quantitative research that measures attitudes and preferences on the return of genomic sequencing results. Based on that review, we studied the return of genetic ancestry since these results, popularized in direct-to-consumer sequencing companies …

Go to article

Characterization Of Cucurbitacin-Inspired Estrone Analogues As Novel Inhibitors Of Human Atp- Binding Cassette Proteins (Abcb1 And Abcc1), Jennifer Kyeremateng Jan 2021

Characterization Of Cucurbitacin-Inspired Estrone Analogues As Novel Inhibitors Of Human Atp- Binding Cassette Proteins (Abcb1 And Abcc1), Jennifer Kyeremateng

Electronic Theses and Dissertations

ATP-binding cassette (ABC) transporters are a large class of integral membrane proteins that contribute to key physiological functions in all organisms by utilizing ATP binding and hydrolysis to transport diverse substrates across membrane barriers. P-glycoprotein (P-gp/ ABCB1) and Multidrug Resistance protein 1 (MRP1/ABCC1) are widely reported ABC transporters associated with multidrug resistance in cancer. Multidrug resistance (MDR) mediated by P-gp and MRP1 is responsible for treatment failures of many metastatic cancers as a result of reduced accumulation, bioavailability and diminished potency of anticancer drugs. Currently, known P-gp and MRP1 inhibitors are limited due to toxicity, lack of selectivity and low …

Go to article

Efficacy Of The In Vitro Splitting Of Human Preimplantation Embryos From Art Programs, Marjan Omidi, Mohammad Ali Khalili, Azam Agha-Rahimi, Stefania Nottola, Fatemeh Anbari, Azita Faramarzi, Maria Grazia Palmerini Jan 2021

Efficacy Of The In Vitro Splitting Of Human Preimplantation Embryos From Art Programs, Marjan Omidi, Mohammad Ali Khalili, Azam Agha-Rahimi, Stefania Nottola, Fatemeh Anbari, Azita Faramarzi, Maria Grazia Palmerini

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate the efficiency of in vitro embryo splitting (IES) procedures. We also assessed the quality of the blastocysts developed from embryos obtained from different sources. Materials and methods: Good quality embryos at 6-8-cell stages were categorized according to their fertilization sources: 1) frozenwarmed donated embryos, 2) chromosomally abnormal embryos, 3) parthenogenetic embryos, and 4) embryos derived from fertilization of in vitro matured oocytes (rescue IVM). After IES, splitting and developmental efficiency was assessed. Furthermore, the quality of the developed blastocysts was evaluated by Hoechst and propidium iodide (PI) staining. Results: The data …

Go to article

Melatonin Has Favorable Preventive Effects On Experimental Chronic Pancreatitis Rat Model, Esra Guzel Tanoglu, Alpaslan Tanoğlu, Makbule Çi̇sel Aydin Meri̇çöz, Muhammed Fevzi̇ Esen Jan 2021

Melatonin Has Favorable Preventive Effects On Experimental Chronic Pancreatitis Rat Model, Esra Guzel Tanoglu, Alpaslan Tanoğlu, Makbule Çi̇sel Aydin Meri̇çöz, Muhammed Fevzi̇ Esen

Turkish Journal of Medical Sciences

Background/aim: Currently, there is not any specific treatment for chronic pancreatitis (CP). It was aimed to investigate the effects of melatonin administration on endoplasmic reticulum (ER) stress, oxidative stress, fibrosis, biochemical and histopathological parameters, and Abcc2,Abcc5, and Abcg2 gene levels in an experimental rat CP model. Materials and methods: Forty rats were randomized into five groups: Sham, CP, CP+25 mg/kg melatonin, CP+50 mg/kg melatonin, and CP+placebo. In all rats, except the sham group, a model of chronic pancreatitis was accomplished with intraperitoneal caerulein administration. In treatment groups, melatonin was used as a therapeutic agent. Serum TGF-ß, TNF-α, MDA and GPx …

Go to article

Oral Cbd Administration: Assessing Bioavailability And Behavioral Outcomes In A Rodent Model, Jordan Skully Jan 2021

Oral Cbd Administration: Assessing Bioavailability And Behavioral Outcomes In A Rodent Model, Jordan Skully

Wayne State University Theses

There has been a recent surge in popularity for cannabidiol (CBD), a major non-psychotropic constituent of cannabis, due to numerous claims of potential therapeutic properties, which include, but are not limited to, anxiolytic, antinociceptive, and anti-inflammatory effects. However, as previous scientific literature on CBD's effectiveness in providing such therapeutic effects is limited, this project was aimed to evaluate the potential beneficial properties of a hemp derived 99% pure CBD compound provided from Ellipse Analytics (Denver, CO) in a rodent model. We analyzed the pharmacokinetics of this CBD product as well as the behavioral outcomes after acute and chronic administration. Pharmacokinetics …

Go to article

Integrative Genome Assembly Of Staphylococcus Epidermidis And Staphylococcus Hominis Strains, Cana L. Brown Jan 2021

Integrative Genome Assembly Of Staphylococcus Epidermidis And Staphylococcus Hominis Strains, Cana L. Brown

Honors Theses

Due to rapid advances in sequencing technology, it is becoming increasingly easier to assemble unknown genomes from millions of short sequencing reads of nucleotides taken from the full genomic sequence (Hernandez, 2008). In this study, we used various computational programs to align reads from unsequenced strains of the bacteria Staphylococcus epidermidis and Staphylococcus hominis into a hitherto undefined, single contiguous genomic sequence. We used SPAdes to assist with template free assembly (Bankevich, 2012), BLAST to identify a suitable reference genome from closely related species (Madden, 2013), Bowtie2 to align our reads to the reference genome, SAMtools to sort and organize …

Go to article

A Novel Role For Neurotensin In Regulation Of Stem Cell Function In The Small Intestine, Stephanie Rock Jan 2021

A Novel Role For Neurotensin In Regulation Of Stem Cell Function In The Small Intestine, Stephanie Rock

Theses and Dissertations--Toxicology and Cancer Biology

Neurotensin (NT) is a nutrient-regulated gut hormone that plays important roles in lipid absorption, obesity, metabolic disorders, and normal and neoplastic growth in the intestine. In this study, we 1) elucidate the mechanisms regulating NT release from endocrine cells, 2) examine the role of NT on proliferation and stem cell function in the small intestine and 3) define the effects of NT on colorectal cancer stem cells. We report that NT release from endocrine cells is enhanced by the MAPK scaffold protein Kinase Suppressor of Ras 1 (KSR1) and the exocyst complex component 70 (Exo70). Moreover, free fatty acid stimulated …

Go to article

First Prev Next Last