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Articles 13321 - 13350 of 24492
Full-Text Articles in Entire DC Network
Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu
Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma. The aim of this study is to present the results of the patients we treated with the diagnosis of EMC as an oncology reference center. Materials and methods: Information on 13 patients diagnosed with EMC between 2006 and 2018 was retrospectively reviewed. Patients' demographic information, tumor sizes, surgical treatments, chemotherapy and radiotherapy statuses, follow-up times, recurrences, and metastases were recorded. Results: Mean patient age was 53.6 ± 15 years (range: 28-73). In 8 patients, the tumor was located in the lower limbs, most commonly in the thigh (46.2%). Mean …
Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca
Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca
Turkish Journal of Medical Sciences
Background/aim: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Materials and methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the …
Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu
Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu
Turkish Journal of Medical Sciences
Background/aim: The use of Transcranial Magnetic Stimulation (TMS) in the add-on treatment of patients with treatment-resistant depression (TRD) is becoming more common. This study aims to investigate the efficacy of TMS on depression and accompanying anxiety symptoms among patients with TRD. Materials and methods: The current study was conducted with 38 patients diagnosed with TRD. The patients were randomly divided into two groups and received 20 sessions of high-frequency (10Hz) TMS and 20 sessions of sham TMS to the left dorsolateral prefrontal cortex in a double-blind and cross-over fashion without a change in their pharmacotherapy. In the clinical evaluation, Hamilton …
Evaluation Of Toxic Effects Of Dapagliflozin On Reproductive System In Diabetic Rats, Bahar Karaca, Tuğçe Boran, Ayça Karagöz Köroğlu, Feri̇ha Ercan, Gül Özhan
Evaluation Of Toxic Effects Of Dapagliflozin On Reproductive System In Diabetic Rats, Bahar Karaca, Tuğçe Boran, Ayça Karagöz Köroğlu, Feri̇ha Ercan, Gül Özhan
Turkish Journal of Medical Sciences
Background/aim: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and genital infections caused by glycosuria. DAPA is subjected to constant additional monitoring, as drugrelated adverse reactions are frequently updated in line with the results of case studies, clinical trials and in vivo studies. Some antidiabetic drugs have shown potential harmful effects on the male reproductive system; however, the effects of DAPA have not been sufficiently studied in this capacity. Aiming to fill this gap in …
Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş
Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş
Turkish Journal of Medical Sciences
Background/aim: Nonalcoholic fatty liver is one of the most common forms of liver disease and role of microRNAs (miRNAs) on this illness is currently unclear. It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. Materials and methods: Twenty-four rats were randomized into three groups: sham (n = 8), experimental fatty liver group (n = 8), and fatty liver + vitamin D3 supplementation group (n = 8). In the treatment group, 10 µg/kg/week of vitamin D3 was given by orogastric tube weekly for …
Frequency Of Alpha-1 Antitrypsin Deficiency And Unexpected Results In Copd Patients In Turkey; Rare Variants Are Common, Mustafa Çörtük, Bariş Demi̇rkol, Meli̇h Akay Arslan, Umut İlhan, Yunus Emre Kalkan, Demet Turan, Şule Gül, Hali̇t Çinarka, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya
Frequency Of Alpha-1 Antitrypsin Deficiency And Unexpected Results In Copd Patients In Turkey; Rare Variants Are Common, Mustafa Çörtük, Bariş Demi̇rkol, Meli̇h Akay Arslan, Umut İlhan, Yunus Emre Kalkan, Demet Turan, Şule Gül, Hali̇t Çinarka, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: Alpha-1 antitrypsin (?1-AT) is a protease inhibitor that is largely released from liver cells. It inhibits neutrophil elastase and its deficiency increases the risk of developing chronic obstructive pulmonary disease (COPD). The frequency of ?1-AT deficiency has been reported with different prevalence rates in different parts of the world. The most common ?1-AT variant causing ?1-AT deficiency is the Pi*Z allele. In this study, we aimed to determine the frequency of the ?1-AT genotypic variant in COPD patients in our country. Materials and methods: In this study, 196 consecutive COPD patients admitted to our clinic were included. In addition …
Comparison Of Anakinra And Tocilizumab In Management Of Severe Covid-19: A Retrospective Cohort Study, Orhan Küçükşahi̇n, Abdulsamet Erden, Özlem Karakaş, Serdar Can Güven, Berkan Armağan, Enes Seyda Şahi̇ner, Osman İnan, Ali̇ Can Kurti̇pek, Emi̇n Gemci̇oğlu, Selma Karaahmetoğlu, Sema Turan, Seval İzdeş, Deni̇z Erdem, Adalet Aypak, Müge Ayhan
Comparison Of Anakinra And Tocilizumab In Management Of Severe Covid-19: A Retrospective Cohort Study, Orhan Küçükşahi̇n, Abdulsamet Erden, Özlem Karakaş, Serdar Can Güven, Berkan Armağan, Enes Seyda Şahi̇ner, Osman İnan, Ali̇ Can Kurti̇pek, Emi̇n Gemci̇oğlu, Selma Karaahmetoğlu, Sema Turan, Seval İzdeş, Deni̇z Erdem, Adalet Aypak, Müge Ayhan
Turkish Journal of Medical Sciences
Background/aim: Studies regarding effectiveness of anakinra and tocilizumab treatments in coronavirus disease 2019 (COVID-19) have contradictory results. Furthermore, there is scarce comparative data regarding superiority of any agent. To further elucidate any superiority between these two agents, we retrospectively investigated and compared outcomes in hospitalized COVID-19 patients of our inpatient cohort who received anakinra or tocilizumab. Materials and methods: This study was designed as a single-center, retrospective, cross-sectional cohort study. Hospitalized patients with confirmed diagnosis of COVID-19 who had Brescia-COVID respiratory severity scale score ?3 and hyperinflammation (defined as elevation of C reactive protein ?50 g/L or ferritin ?700 ng/mL) …
Serum Visfatin Concentrations Are Positively Associated With Ventricular Arrhythmias: A Single-Center Preliminary Study, Rongrong Shen, Peiyu Zhang, Rong Guo, Yawei Xu
Serum Visfatin Concentrations Are Positively Associated With Ventricular Arrhythmias: A Single-Center Preliminary Study, Rongrong Shen, Peiyu Zhang, Rong Guo, Yawei Xu
Turkish Journal of Medical Sciences
Background/aim: Visfatin has been reported to be closely related to cardiovascular diseases associated with inflammation, but the correlation between visfatin and ventricular arrhythmia (VA) has not been discussed yet. The study aims to explore the association between serum visfatin concentrations and VA in patients. Materials and methods: Sixty-seven hospitalized patients diagnosed with VA and 131 control subjects were enrolled in this crosssectional study between May 20, 2017 and November 8, 2019. Classification of VA types was based on the presence of structural heart disease (SHD). The patients? blood samples were collected to examine their serum levels of visfatin. Results were …
What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz
What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R + Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum according to stereotaxic …
Using Electrooculography With Visual Stimulus Tracking Test In Diagnosing Of Adhd: Findings From Machine Learning Algorithms, Fatma Lati̇foğlu, Mustafa Yasi̇n Esas, Rami̇s İleri̇, Sevgi̇ Özmen, Esra Demi̇rci̇
Using Electrooculography With Visual Stimulus Tracking Test In Diagnosing Of Adhd: Findings From Machine Learning Algorithms, Fatma Lati̇foğlu, Mustafa Yasi̇n Esas, Rami̇s İleri̇, Sevgi̇ Özmen, Esra Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: Attention deficit hyperactivity disorder (ADHD), one of the most common neurodevelopmental disorders in childhood, is diagnosed clinically by assessing the symptoms of inattention, hyperactivity, and impulsivity. Also, there are limited objective assessment tools to support the diagnosis. Thus, in this study, a new electrooculography (EOG) based on visual stimulus tracking to support the diagnosis of ADHD was proposed. Materials and methods: Reference stimulus one-to-one tracking numbers (RSOT) and colour game detection (CGD) were applied to 53 medication-free children with ADHD and 36 healthy controls (HCs). Also, the test was applied six months after the treatment to children with ADHD. …
Copy Number Variations In Patients With Idiopathic Recurrent Pregnancy Loss: An Arraycgh Approach, Onur Yildiz, Fatma Silan, Taner Karakaya, Öztürk Özdemi̇r
Copy Number Variations In Patients With Idiopathic Recurrent Pregnancy Loss: An Arraycgh Approach, Onur Yildiz, Fatma Silan, Taner Karakaya, Öztürk Özdemi̇r
Turkish Journal of Medical Sciences
Background/aim: It is not always possible to determine the causative basis of pregnancy losses and even today it has been reported that 50% of cases with recurrent pregnancy loss (RPL) have no reason to be detected. In our study, it is aimed to reveal the copy number variations (CNVs) of the genes which presumably have a potential effect in individuals with RPL and contribute to subsequent functional studies in the follow-up. Materials and methods: We retrospectively evaluated the array-comparative genomic hybridization (aCGH) data of cytogenetically 64 normal individuals (21 couples, 11 unrelated women, and 11 unrelated men) who had applied …
Is The Treatment Of Inflammatory Arthritis Different In Sickle Cell Disease?, Gezmi̇ş Ki̇myon, Gül İlhan
Is The Treatment Of Inflammatory Arthritis Different In Sickle Cell Disease?, Gezmi̇ş Ki̇myon, Gül İlhan
Turkish Journal of Medical Sciences
Background/aim: Musculoskeletal findings are common in sickle cell patients and may be confused with inflammatory arthritis. In addition, complications such as frequent infections may create difficulties while choosing drugs such as steroids, methotrexate, or antiTNFs. Our aim is to reveal whether the treatment is different in sickle cell patients with rheumatic diseases such as rheumatoid arthritis. Materials and methods: Patients followed by Rheumatology and Hematology divisions of Hatay Mustafa Kemal University Hospital were retrospectively screened. Excluding patients with musculoskeletal findings associated with sickle cell disease (SCD), patients with chronic or acute inflammatory arthritis were enrolled into study. Demographic data, disease …
Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari
Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari
Turkish Journal of Medical Sciences
Background/aim: The revised Leeds Disability Questionnaire (RLDQ) is a unique assessment tool for patients with ankylosing spondylitis (AS); its comprehensive structure includes posture and neck flexibility parameters. The aim of the study was to determine the psychometric properties of the Turkish RLDQ in patients with AS. Materials and methods: A total of 100 AS patients were enrolled in the study. In the first evaluation, patients filled out the Dougados Functional Index (DFI) and Bath Ankylosing Spondylitis Functional Index (BASFI), Stanford Health Assessment Questionnaire (HAQ) in addition to RLDQ. Then, patients were refilled the revised RLDQ in the second assessment. Results: …
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Turkish Journal of Medical Sciences
Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement …
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Turkish Journal of Medical Sciences
Background/aim: Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor (AR) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects. Materials and methods: This was a cross-sectional study conducted at Aga Khan University, Karachi, Pakistan. A total of 376 males were recruited, out of which group A (N = 208) and group B (N = 168) were comprised of …
Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci
Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci
Turkish Journal of Medical Sciences
Background/aim: Intravesical BCG treatment fails inexplicably in 30%-45% of patients for high-grade nonmuscle-invasive bladder cancer (NMIBC). We aimed to investigate the role of PD-1/PD-L1 interaction on BCG failure of high-grade NMIBC and to identify biomarkers for predicting BCG responsive cases. Materials and methods: Thirty BCG responsive and 29 nonresponsive NMIBCs were included in the study. Expressions of PDL1(SP-263), MSH2, MSH6, PMS2, and MLH1 were evaluated on pre- and post-BCG transurethral resection (TUR-B) specimens by immunohistochemistry. PD-L1(SP-263) expression was categorised as negative/low, high. DNA mismatch repair protein (MMR) expressions were classified as 'reduced' if ≤30% of nuclei stained, 'preserved' if >30% …
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Nicotine acts as an agonist of nicotinic acetylcholine receptors (nAChR). These receptors belong to a superfamily of ligand-gated ion channels. We previously demonstrated that nicotine increased electrical field stimulation (EFS)-induced contractile or relaxation responses, possibly by facilitating neurotransmitter release from nerve terminals in various rabbit tissues. Studies have shown that there is an interaction between the endocannabinoid and nicotinic systems. This study aimed to investigate the interaction between nicotine and the endocannabinoid system in the rabbit urine bladder and also investigate the enhancing effect of nicotine on EFS-induced contractile responses in rabbit isolated bladder smooth muscle and its interaction …
Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara
Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara
Turkish Journal of Medical Sciences
Background/aim: The level of nitric oxide (NO) is important to protect the heart from ischemic damage in acute coronary syndrome (ACS) patients. S-nitrosothiol (SNO) is a molecule that represents the main form of NO storage in the vascular structure. In addition, dynamic thiol/disulfide homeostasis (TDH) is known to play an important role in maintaining the oxidant-antioxidant balance. In this study, our aim is to evaluate the oxidative/nitrosative stress status according to SNO level and TDH in patients with ACS. Materials and methods: The study included 124 patients who were admitted to the emergency service and 124 consecutive individuals who applied …
Investigation Of Ceftazidime-Avibactam Susceptibility In Clinical Isolates Of Gram-Negative Bacteria, Ridvan Dumlu, Neval Yurttutan Uyar, Meltem Ayaş, Ni̇lay Aksoy, Nur Öztürk, Ayşe Sesi̇n Kocagöz
Investigation Of Ceftazidime-Avibactam Susceptibility In Clinical Isolates Of Gram-Negative Bacteria, Ridvan Dumlu, Neval Yurttutan Uyar, Meltem Ayaş, Ni̇lay Aksoy, Nur Öztürk, Ayşe Sesi̇n Kocagöz
Turkish Journal of Medical Sciences
Background/aim: Our study investigated the susceptibility rate of ceftazidime-avibactam and the risk factors associated with its resistance by analyzing gram-negative bacteria isolated from various patient samples. Materials and methods: Between March and November 2020, 1119 gram-negative bacteria strains were isolated from patient samples in Acıbadem Healthcare Group hospitals; ceftazidime-avibactam susceptibility results were evaluated using a 10/4µg (Oxoid, UK) disc and evaluated according to Eucast 2020 recommendations. Patient and isolate characteristics that could be risk factors were retrospectively investigated and statistically analyzed using SPSS 25.0. Results: Male patients made up 52% (n = 581) of the study's total patient population, and …
Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli
Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli
Turkish Journal of Medical Sciences
Background/aim: Systemic sclerosis (SSc) is a chronic systemic disease characterized by vascular damage, autoimmunity, and fibrosis in the skin and internal organs. In this study, we tried to determine the causes of severe infection in patients with SSc and to reveal the factors associated with severe infection. Materials and methods: We retrospectively examined 214 SSc patients between January 2010 and August 2020. Forty-seven patients with at least one severe infection and 167 patients without severe infection were compared. Results: A total of 76 episodes of severe infections were detected in 47 (22%) patients. Common infections included pneumonia, infected digital ulcer, …
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Turkish Journal of Medical Sciences
Background/aim: Sarcopenia and dementia are growing concerns among older adults that muscle and brain atrophy may cooccur. We aimed to compare the age-related loss of muscle mass by using ultrasound (US), and skeletal muscle mass index (SMI) by bioelectrical impedance analysis in older adults with and without dementia. Materials and methods: A total of 221 older adults aged ≥65 years were included in the study. The diagnosis of sarcopenia was established if low muscle mass according to either SMI or sonographic gastrocnemius (GC) muscle thickness was combined with low grip strength. The diagnosis of dementia was based on the National …
Central Vein Sign: Comparison Of Multiple Sclerosis And Leukoaraiosis, Hüseyi̇n Gökhan Yavaş, Ergi̇n Sağtaş
Central Vein Sign: Comparison Of Multiple Sclerosis And Leukoaraiosis, Hüseyi̇n Gökhan Yavaş, Ergi̇n Sağtaş
Turkish Journal of Medical Sciences
Background/aim: Leukoaraiosis produces white matter lesions (WML) similar to multiple sclerosis (MS) on brain magnetic resonance imaging (MRI), and the distinction between these two conditions is difficult radiologically. This study aimed to investigate the role of the central vein sign (CVS) in susceptibility-weighted imaging (SWI) sequence in distinguishing MS lesions from leukoaraiosis lesions in Turkish population. Materials and methods: In this prospective study, axial SWI and sagittal three-dimensional fluid-attenuated inversion recovery (3DFLAIR) were obtained in 374 consecutive patients. The study consisted of 169 (89 MS patients, 80 patients with leukoaraiosis) patients according to the inclusion and exclusion criteria. Two observers …
The Correlations Between Dynamic Contrast Enhanced Magnetic Resonance Imaging And Immunohistochemical Data In Head And Neck Squamous Cell Carcinomas, Nuri̇ Karabay, Hande Meli̇ke Bülbül, Ersoy Doğan, Ahmet Ömer İki̇z, Gökseni̇l Bülbül, Sülen Sarioğlu
The Correlations Between Dynamic Contrast Enhanced Magnetic Resonance Imaging And Immunohistochemical Data In Head And Neck Squamous Cell Carcinomas, Nuri̇ Karabay, Hande Meli̇ke Bülbül, Ersoy Doğan, Ahmet Ömer İki̇z, Gökseni̇l Bülbül, Sülen Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) can in vivo characterize tumor microvascular environment. The aim of the present study was to reveal the DCE-MRI findings and to determine the correlation between these findings and immunohistochemical data in head and neck squamous cell carcinoma (HNSCC). Materials and methods: Thirty-three patients diagnosed with primary HNSCC were evaluated retrospectively. DCE-MRI was conducted in all cases. CD34, CD105, and ki-67 expressions were analyzed with immunohistochemistry in tissue sections to determine micro-vessel density and proliferative activity. Results: The DCE-MRI is a successful technique in distinguishing tumor tissue from normal tissue. It was determined …
Frailty In Community-Dwelling Older Adults: Reliability And Validity Of The Turkish Version Of The Gérontopôle Frailty Screening Tool, Serdar Ceylan, Merve Güner Oytun, Arzu Okyar Baş, Meltem Koca, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Cafer Balci
Frailty In Community-Dwelling Older Adults: Reliability And Validity Of The Turkish Version Of The Gérontopôle Frailty Screening Tool, Serdar Ceylan, Merve Güner Oytun, Arzu Okyar Baş, Meltem Koca, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Cafer Balci
Turkish Journal of Medical Sciences
Background/aim: Recognizing frailty had a great importance in countries with an increasing geriatric population. The study aims to evaluate the reliability and validation of the Gérontopôle frailty screening tool (GFST), which was developed to screen frailty in the community-dwelling older adults, for the Turkish population. Materials and methods: In this crosssectional study, participants who applied to the geriatrics outpatient clinic of a university hospital were included. Comprehensive geriatric assessments of all patients were performed. The validity of the GFST was tested by its concordance with the FRAIL scale. Test-retest and interrater reliability analyses were made. Results: Ninety-six patients were included …
Expanding Mouse-Adapted Yamagata-Like Influenza B Viruses In Eggs Enhances In Vivo Lethality In Balb/C Mice, Matthew J. Pekarek, Erika M. Petro-Turnquist, Adam Rubrum, Richard J. Webby, Eric A. Weaver
Expanding Mouse-Adapted Yamagata-Like Influenza B Viruses In Eggs Enhances In Vivo Lethality In Balb/C Mice, Matthew J. Pekarek, Erika M. Petro-Turnquist, Adam Rubrum, Richard J. Webby, Eric A. Weaver
Nebraska Center for Virology: Faculty Publications
Despite the yearly global impact of influenza B viruses (IBVs), limited host range has been a hurdle to developing a readily accessible small animal disease model for vaccine studies. Mouseadapting IBV can produce highly pathogenic viruses through serial lung passaging in mice. Previous studies have highlighted amino acid changes throughout the viral genome correlating with increased pathogenicity, but no consensus mutations have been determined. We aimed to show that growth system can play a role in mouse-adapted IBV lethality. Two Yamagata-lineage IBVs were serially passaged 10 times in mouse lungs before expansion in embryonated eggs or Madin–Darby canine kidney cells …
Dissecting The Cellular Landscape And Transcriptome Network In Viral Myocarditis By Single-Cell Rna Sequencing, Ninaad Lasrado, Nicholas Borcherding, Rajkumar Arumugam, Timothy K. Starr, Jay Reddy
Dissecting The Cellular Landscape And Transcriptome Network In Viral Myocarditis By Single-Cell Rna Sequencing, Ninaad Lasrado, Nicholas Borcherding, Rajkumar Arumugam, Timothy K. Starr, Jay Reddy
School of Veterinary and Biomedical Sciences: Faculty Publications
Coxsackievirus B3 (CVB3)-induced myocarditis is commonly employed to study viral pathogenesis in mice.Chronically affected micemaydevelop dilated cardiomyopathy, which may involve the mediation of immune and nonimmune cells. To dissect this complexity, we performed single-cell RNA sequencing on heart cells from healthy and myocarditic mice, leading us to note significant proportions of myeloid cells, T cells, and fibroblasts. Although the transcriptomes of myeloid cells were mainly of M2 phenotype, the Th17 cells, CTLs, and Treg cells had signatures critical for cytotoxic functions. Fibroblasts were heterogeneous expressing genes important in fibrosis and regulation of inflammation and immune responses. The intercellular communication networks …
Fabrication And Characterization Of Methylprednisolone-Loaded Polylactic Acid/Hyaluronic Acid Nanofibrous Scaffold For Soft Tissue Engineering, Mehdi Keikha, Elahe Entekhabi, Mahvash Shokrollahi, Masoumeh Haghbin Nazarpak, Zahra Hassannejad, Somaye Akbari, Alex R. Vaccaro, Vafa Rahimi-Movaghar
Fabrication And Characterization Of Methylprednisolone-Loaded Polylactic Acid/Hyaluronic Acid Nanofibrous Scaffold For Soft Tissue Engineering, Mehdi Keikha, Elahe Entekhabi, Mahvash Shokrollahi, Masoumeh Haghbin Nazarpak, Zahra Hassannejad, Somaye Akbari, Alex R. Vaccaro, Vafa Rahimi-Movaghar
Rothman Institute Papers
Previous in vitro and in vivo studies have indicated that tissue engineering scaffolds, including Schwann cells, may improve axonal regeneration, particularly in combination with Methylprednisolone as an influential neuroprotective factor. The primary aim of this study was to design composite electrospun scaffolds based on polylactic acid (PLA)/ hyaluronic acid (HA) containing various percentages (0.05–2% (w/v)) of Methylprednisolone (MP) with suitable mechanical and chemical properties for soft tissue especially to promote nerve growth. For the first time, MP was implicated in a PLA/HA nanofibrous and its effect on fiber’s properties was scrutinized as a candidate for nerve tissue.
Monitoring The Systemic Immune System To Understand And Improve The Efficacy Of Immunotherapy For Metastatic Osteosarcoma, Justin Edward Markel
Monitoring The Systemic Immune System To Understand And Improve The Efficacy Of Immunotherapy For Metastatic Osteosarcoma, Justin Edward Markel
Graduate Theses, Dissertations, and Problem Reports (ETD)
Osteosarcoma (OS) is a complex tumor with no effective targeted therapies due to its genomic heterogeneity and pleomorphism. The immune response it creates, particularly against metastatic lesions, is considerable; however, various suppressive mechanisms induced by the tumor prohibit its effectiveness. The presence of infiltrating lymphocytes suggests that therapeutic disinhibition through checkpoint blockade could increase antitumor immunity, though none have been successful in clinical trials. The complexities of the immune response to OS tumors have yet to be unraveled; however, there is evidence to suggest that cell-mediated immunity (CMI, specifically T cells, Natural Killer [NK] cells, and myeloid-lineage cells [MLCs]) plays …
A Serological Analysis Of Sars-Cov-2 Infection In The Obstetric Population, Sophia Rose
A Serological Analysis Of Sars-Cov-2 Infection In The Obstetric Population, Sophia Rose
CMC Senior Theses
In December 2019, the surfacing and spread of a novel coronavirus, SARS-CoV-2, resulted in the global COVID-19 pandemic. As a viral antigen, SARS-CoV-2 poses a particular threat to the obstetric population due to physiological and immunological changes that women face during pregnancy. While recent studies have found that SARS-CoV-2 may have better clinical outcomes as compared to other betacoronaviruses, adverse pregnancy events such as ICU admission, preeclampsia, and/or preterm birth have been associated with COVID-19. Progress has been made in better understanding the pathophysiology of SARS-CoV-2 in pregnancy, but there is still much to be known about the interaction …
A Study Of Limited Bedding And Nesting On Maternal Behavior For Postpartum Depression, Emma Brezoczky
A Study Of Limited Bedding And Nesting On Maternal Behavior For Postpartum Depression, Emma Brezoczky
CMC Senior Theses
Postpartum depression (PPD) affects up to 20% of mothers in the US and can detrimentally affect both the mother and psychosocial development of the child (Pearlstein et al, 2009). So far, research on PPD is limited and the underlying neuropathology remains unclear. Low socioeconomic status is one risk factor that increases the risk of PPD tenfold (Goyal et al, 2010). The low resource limited bedding and nesting (LBN) paradigm used for rodents has the potential to model this risk factor. LBN has not previously been studied with PPD, but observations of disrupted maternal behaviors and depressive phenotypes makes it a …