Digital Commons Network^™

Adverse Events Associated With Exchange Transfusion And Etiology Of Severe Hyperbilirubinemia In Near-Term And Term Newborns, Ali̇ Bülbül, Feri̇de Füsun Okan, Emel Kabakoğlu Ünsür, Asi̇ye Nuhoğlu

Turkish Journal of Medical Sciences

To assess clinical features, etiology, and complications in term and near-term newborns who received exchange transfusion. Materials and methods: Infants with >=35 gestational weeks admitted to our neonatal intensive care unit in the first 30 days of life and underwent exchange transfusion due to severe hyperbilirubinemia between 2002 and 2008 were included. Clinical features, etiology of hyperbilirubinemia, and complications of exchange transfusion were assessed. Results: Exchange transfusion was performed 86 times in a total of 73 patients. Eleven patients received exchange transfusion twice, and 1 patient 3 times. A great proportion of the patients (61.6%) were male, and mean (± …

The Role Of Red Cell Distribution Width As A Marker In Inflammatory Bowel Disease, Mehmet Arhan, İbrahi̇m Koral Önal, Adnan Taş, Mevlüt Kurt, İsmai̇l Hakki Kalkan, Yasemi̇n Özi̇n, Bi̇lge Tunç, Aysel Ülker

Turkish Journal of Medical Sciences

To determine whether red cell distribution width could be used for the assessment of disease activity in patients with inflammatory bowel disease. Materials and methods: A total of 165 patients with inflammatory bowel disease (105 ulcerative colitis; 60 Crohn's disease) and 43 healthy blood donors were included in this retrospective study in a tertiary care setting. The medical records of the patients were reviewed to note clinical activity indices, red cell distribution width, serum C reactive protein, erythrocyte sedimentation rates, leukocyte, and platelet counts. Results: Red cell distribution width, serum C reactive protein, erythrocyte sedimentation rate, platelet count, and the …

Glutamate Dehydrogenase And Triose-Phosphate-Isomerase Coding Genes For Detection And Genetic Characterization Of Giardia Lamblia In Human Feces By Pcr And Pcr-Rflp*, Kareem Hatam Nahavandi, Esmaeel Fallah, Mohammad Asgharzadeh, Nasrin Mirsamadi, Behroz Mahdavipour

Turkish Journal of Medical Sciences

The purpose of this study was comparison of the glutamate dehydrogenase (gdh) and triose phosphate isomerase (tpi) genes for detection and genetic characterization of Giardia lamblia (G. lamblia) in human stool by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP). Our assay was specific and distinguished between G. lamblia assemblages A and B. Materials and methods: Among the 325 stool samples obtained from patients with acute gastroenteritis hospitalized in the Pediatric Hospital and infected humans referred to the Tabriz Reference Laboratory (TRL), 34 Giardia-positive stool samples were identified by conventional techniques. Two assays-PCR and PCR-RFLP-targeting the tpi and …

A Determination Of The Factors That Affect The Level Of Pediatric Nurses' Liking Of Children, Yurdagül Erdem, Veli̇ Duyan

Turkish Journal of Medical Sciences

Every person under the age of 18 is a child. One's attitude towards children is made up of the person's basic beliefs about children and their reaction to the idea of being with children. Pediatric nurses are expected to understand children's physical, intellectual, emotional, and social development, to advocate for children, and to show affection towards and interest in children. This study is conducted to determine the level of liking of children of nurses who are working at pediatric clinics. Materials and methods: This descriptive study was conducted on 207 nurses employed at pediatric clinics of university and state hospitals. …

Evaluation Of Health-Related Quality Of Life Of Women Living In A City Center In The East Of Turkey, Nüket Paksoy Erbaydar, Nazmi̇ Bi̇li̇r, Lütfi̇ye Hi̇lal Özcebe, Songül Vai̇zoğlu, Di̇lek Aslan

Turkish Journal of Medical Sciences

To evaluate the health-related quality of life of women living in Van city center by SF-36 and its association with the women's characteristics. Materials and methods: The women (n = 1527) answered a questionnaire through a face-to-face interview, and some measurements were made. The variations of physical component score (PCS) and mental component score (MCS) of SF-36 were investigated by non-parametric tests, and by linear regression analysis. Results: The percentage of early marriages among married women was 55.6. Number of pregnancies per married woman was 4.5 ± 2.8, the lowest mean in vitality (44.0 ± 20.6) and the highest mean …

The Impact Of Nih-Iv Prostatitis On Early Post-Operative Outcomes Of The Impact Of Nih-Iv Prostatitis On Early Post-Operative Outcomes Of Transurethral Resection Of The Prostate In Patients With Symptomatic Benign Prostate Hyperplasia, Fati̇h Rüştü Yalçinkaya, Ahmet Gökçe, Mürsel Davarci, Eşref Oğuz Güven, Mehmet İnci̇, Süleyman Bariş Kartal, Ali̇ Ayyildiz, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

Transurethral prostate resection (TURP) is still considered the gold standard in the treatment of symptomatic benign prostate hyperplasia (BPH). Category IV chronic prostatitis (CP) is described by the National Institute of Health (NIH-IV) as the asymptomatic inflammation of the prostate and it may be detected along with benign prostate hyperplasia (BPH) during histological examinations of the prostate. In this study, we evaluate the impact of the presence of NIH-IV defined prostatitis on early post-operative outcomes of transurethral resection of the prostate. Materials and methods: Between 2004 and 2008, medical records of 247 patients who underwent TURP in Adana Numune Training …

The Effects Of P53 Inhibition Using Pifithrin-Α On Acute Necrotizing Pancreatitis In Rats, Etem Alhan, Aki̇f Ci̇nel, Mehmet Cengi̇z Erçi̇n, Serdar Türkyilmaz, Bi̇rgül Vani̇zor Kural, Murat Alper, Deni̇z Fi̇li̇nte

Turkish Journal of Medical Sciences

To investigate the effects of p53 inhibition using pifithrin-\alpha (PFA) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. The role of p53 during acute pancreatitis is unclear. Materials and methods: Rats were divided into 4 groups, 2 of which were initially given only saline (the sham group) and 2 of which were given glycodeoxycholic acid in order to induce ANP. Each group was then identified according to treatment plan: sham+saline, sham+PFA, ANP+saline, or ANP+PFA. The study then investigated the extent of acinar cell injury, apoptosis, mortality, systemic cardiorespiratory variables, functional capillary density (FCD), renal/hepatic functions, and changes …

Subclinical Hypoxia Of Infants With Intrauterine Growth Retardation Determined By Increased Serum S100b Protein Levels, Özlem Kirmemi̇ş, Mustafa Mansur Tatli, Cüneyt Tayman, Cemi̇le Koca, Ahmet Karadağ, Nurdan Uras, Uğur Di̇lmen, Hasan Kafali

Turkish Journal of Medical Sciences

To test the hypothesis that serum S100B levels could be useful in detecting neurological damage in infants with intrauterine growth retardation (IUGR). Materials and methods: The study group consisted of infants with IUGR and the control group consisted of age-matched healthy infants. S100B protein levels were measured after birth and compared between groups. Results: For this study, 43 infants with IUGR and 25 infants as a control group were recruited. Gender, gestational age, type of delivery, and maternal age of the groups were statistically insignificant, with the exception of the mean birth weights (2120 ± 450 g in the IUGR …

Nosocomial Candidemia: A Threat Beyond Nosocomial Bacterial Infections In Intensive Care Units, Emi̇ne Alp Meşe, Çi̇ğdem Ağkuş, Ramazan Coşkun, Gökhan Metan, Ayşe Nedret Koç, Murat Sungur, Mehmet Doğanay

Turkish Journal of Medical Sciences

There is no abstract

Getting To Know You: Key Clinical Concepts In Relationship-Based Interventions And Neurobehavioral Observations With Young Infants, Yvette Blanchard

All PTHMS Faculty Publications

The newborn infant is a social organism, pre-disposed to interact with his caregiver and able to elicit the kind of caregiving necessary for successful adaptation. The earliest developmental task of the newborn is to organize behavior to be able to play an active role in influencing the caregiving environment and eliciting the kind of support needed for development. This task is accomplished through the attainment of self-regulation or balanced neurobehavioral functioning of the infant's autonomic, motor, state, and responsivity behavioral dimensions as described by Als.

Suggested Improvements For The Allergenicity Assessment Of Genetically Modified Plants Used In Foods, Richard E. Goodman

Department of Food Science and Technology: Faculty Publications

Genetically modified (GM) plants are increasingly used for food production and industrial applications. As the global population has surpassed 7 billion and per capita consumption rises, food production is challenged by loss of arable land, changing weather patterns, and evolving plant pests and disease. Previous gains in quantity and quality relied on natural or artificial breeding, random mutagenesis, increased pesticide and fertilizer use, and improved farming techniques, all without a formal safety evaluation. However, the direct introduction of novel genes raised questions regarding safety that are being addressed by an evaluation process that considers potential increases in the allergenicity, toxicity, …

An Evidence-Based Review Of Fat Modifying Supplemental Weight Loss Products., Amy M Egras, William R Hamilton, Thomas L Lenz, Michael S Monaghan

College of Pharmacy Faculty Papers

Objective. To review the literature on fat modifying dietary supplements commonly used for weight loss. Methods. Recently published randomized, placebo-controlled trials were identified in PubMed, MEDLINE, International Pharmaceutical Abstracts, Cochrane Database, and Google Scholar using the search terms dietary supplement, herbal, weight loss, obesity, and individual supplement names. Discussion. Data for conjugated linoleic acid (CLA), Garcinia cambogia, chitosan, pyruvate, Irvingia gabonensis, and chia seed for weight loss were identified. CLA, chitosan, pyruvate, and Irvingia gabonensis appeared to be effective in weight loss via fat modifying mechanisms. However, the data on the use of these products is limited. Conclusion. Many obese …

Obesity In Children And Adolescents And Its Relationship With Hypertension, Dr Vijayanath Itagi, Ramesh Patil

Turkish Journal of Medical Sciences

It is difficult to project the prevalence of obesity and overweight among children in India since there is no nationally representative data from India. We determined the time trends in childhood obesity in a representative sample of schoolchildren from Raichur District, Karnataka and investigated the relationship of obesity with blood pressure. Materials and methods: We used a stratified random cluster sampling method to select the children. Anthropometric data were collected from 23,842 students, 5-16 years of age, during 2005-06. Blood pressure and anthropometric data were collected from 19,263 students during 2007-08. Overweight and obesity were defined by body mass index …

The Role Of Anemia And Vitamin D Levels In Acute And Chronic Telogen Effluvium, Ayşe Serap Karadağ, Derun Taner Ertuğrul, Emre Tutal, Kadi̇r Okhan Akin

Turkish Journal of Medical Sciences

Telogen effluvium (TE) is an abnormality of hair cycling. Vitamin D promotes hair follicle differentiation. The importance of vitamin D in hair growth is evident in patients with hereditary vitamin D receptor deficiency. The role of vitamin D in the pathogenesis of TE has not been investigated before. We investigated the role of vitamin D, ferritin, and zinc in the pathogenesis of TE. Materials and methods: We measured serum hemoglobin, ferritin, zinc, calcium, phosphate, parathormone, magnesium, 25 and 1,25-hydroxyvitamin D3, and bone alkaline phosphatase and thyroid stimulating hormone levels in 63 female patients and 50 control subjects. Twenty-nine of the …

Molecular Mechanisms Regulating Caenorhabditis Elegans Sperm Migration, Johnathan Wesley Edmonds

All ETDs from UAB

Fertilization is the process by which male and female gametes join to give rise to a new organism. Union of sperm and ova requires that sperm be able to successfully locate and migrate towards oocytes in the female reproductive tract. By analyzing the in vitro migration of sperm from diverse species and mapping the complex architecture of their female reproductive tracts, we can infer that sperm must respond to directional cues to seek out the mature oocyte. However, the internal fertilization schemes of most complex animals complicate the analysis of in vivo sperm migration. The transparent epidermis of the nematode …

Faculty Publications 2010, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 844 publications.

Glial Differentiation Of Human Umbilical Stem Cells In 2d And 3d Environments, Hedvika Davis

Electronic Theses and Dissertations

During differentiation stem cells are exposed to a range of microenvironmental chemical and physical cues. In this study, human multipotent progenitor cells (hMLPCs) were differentiated from umbilical cord into oligodendrocytes and astrocytes. Chemical cues were represented by a novel defined differentiation medium containing the neurotransmitter norepinephrine (NE). In traditional 2 dimensional (2D) conditions, the hMLPCs differentiated into oligodendrocyte precursors, but did not progress further. However, in a constructed 3 dimensional (3D) environment, the hMLPCs differentiated into committed oligodendrocytes that expressed MBP. When co-cultured with rat embryonic hippocampal neurons (EHNs), hMLPCs developed in astrocytes or oligodendrocytes, based on presence of growth …

The Effect Of High Dose Total Body Irradiation On Acth, Corticosterone, And Catecholamines In The Rat, Eric P. Cohen, Eric D. Bruder, William E. Cullinan, Dana R. Ziegler, Hershel Raff

Biomedical Sciences Faculty Research and Publications

Total body irradiation (TBI) or partial body irradiation is a distinct risk of accidental, wartime, or terrorist events. Total body irradiation is also used as conditioning therapy before hematopoietic stem cell transplantation. This therapy can result in injury to multiple tissues and might result in death as a result of multiorgan failure. The hypothalamic–pituitary–adrenal (HPA) axis could play a causative role in those injuries, in addition to being activated under conditions of stress. In a rat model of TBI, we have established that radiation nephropathy is a significant lethal complication, which is caused by hypertension and uremia. The current study …

Cardiac Output Is Not Related To The Slowed O2 Uptake Kinetics In Type 2 Diabetes, Oscar Mac Ananey, J Malone, S Warmington, D O'Shea, S Green, M Egana

Articles

Abstract

PURPOSE:

This study aimed to investigate whether cardiac output (CO) responses were related to VO2 kinetics during cycling in type 2 diabetes.

METHODS:

A total of 9 middle-aged women with uncomplicated type 2 diabetes, 9 nondiabetic overweight women, and 11 nondiabetic lean women were recruited. Initially, the ventilatory threshold (VT) and peak VO2 were determined during a maximal graded test. Then, on two separate days, subjects completed three 7-min bouts of constant-load cycling at each of three intensities: 50% VT, 80% VT, and midpoint between VT and peak VO2 (50% Δ). CO (inert gas rebreathing) was recorded at 30 …

Significance And Regulation Of Cd68 Expression In The Osteoclast, Jason Waid Ashley

All ETDs from UAB

The mucin-like Lysosome Associated Membrane Protein (LAMP) family member CD68 is a primarily myeloid lineage restricted transmembrane protein that is expressed in macrophages and osteoclasts. While the existence and expression pattern of human CD68 and mouse CD68 (sometimes called macrosialin) are well-known, and these molecules are routinely used as histological markers of tissue macrophages, the functional signific-ance of CD68 expression remains an unanswered question. Our overall goal is to deter-mine the significance and characterize the function of CD68 in osteoclasts and explore the effects of Receptor Activator of Nuclear Factor κB (RANK) signaling on CD68 post-translational modification. To achieve this …

Pediatric Obesity And Traumatic Lower Extremity Long Bone Fracture Outcomes, Ian Charles Backstrom

All ETDs from UAB

Background: Pediatric obesity is associated with lower extremity injuries and poor outcomes after blunt trauma. Our aim was to determine if obese pediatric patients with femur and tibia fractures have more severe injury patterns and worse outcomes compared to non-obese patients. Methods: We performed a retrospective cohort study of obese and non-obese pediatric patients with femur or tibia fractures treated at two Level-1 trauma centers from 2004-2010. Patients weighing ≥ 95th percentile for age and gender were classified as obese. Patients were compared regarding demographics, Injury Severity Score (ISS), intra-abdominal, and orthopedic injuries. Outcomes included fracture treatment, orthopedic complications, ICU …

The Requisite Role Of Dectin-1 And Il-17 In Innate Host Defense Against Aspergillus Fumigatus, Jessica L. Werner

All ETDs from UAB

Immune suppression increases the incidence of invasive fungal infections, particularly those caused by the opportunistic mold Aspergillus fumigatus. We show that non-immunosuppressed mice lacking the beta-glucan receptor Dectin-1 (Dectin-1-/-) are more susceptible to intratracheal challenge with A. fumigatus than control mice, exhibiting >80% mortality within 5 days; ultimately attributed to a compromise in respiratory mechanics. In response to A. fumigatus challenge, Dectin-1-/- mice demonstrated impaired inflammatory response as seen through defective cytokine and chemokine production, which resulted in insufficient lung neutrophil recruitment and uncontrolled A. fumigatus lung growth. Alveolar macrophages from Dectin-1-/- mice failed to produce proinflammatory mediators in response …

The Effects Of Pre-Exercise Carbohydrate Supplementation On Resistance Training Performance During An Acute Resistance Training Session, Kelly Raposo

USF Tampa Graduate Theses and Dissertations

It appears that "carbohydrate loading" may enhance the performance of resistance training, but studies on CHO supplementation prior to a resistance-training bout are limited and have resulted in conflicting findings. PURPOSE: To investigate the effects of pre-exercise CHO supplementation on high-intensity (>75% 1RM) resistance training performance for resistance-trained women during an acute bout of resistance exercise. METHODS: Thirteen resistance trained female participants (21.9 ± 4.8 yrs; 64.5 ± 3.0 in; 137.0 ± 14.8 lbs) came to the Exercise and Performance Nutrition Laboratory on three separate occasions; the day of the Familiarization Trial (FT) and the two Exercise Testing sessions …

The Effect Of Various Carbohydrate Supplements On Postprandial Blood Glucose Response In Female Soccer Players, Nina Pannoni

USF Tampa Graduate Theses and Dissertations

PURPOSE: The purpose of this study is to examine the effects of different types of carbohydrates on blood glucose response in collegiate soccer athletes at rest. This will help to determine the effectiveness of a carbohydrate supplement in providing sustained energy and maintained performance if ingested prior to a soccer match. METHODS: In a cross-over design, 10 female collegiate soccer players (n= 10, age 20.10 ± .99 years, height 65.55 ± 2.77 inches, weight 64.12 ± 8.36 kilograms) from the University of South Florida reported to the laboratory on five separate occasions after an overnight fast. Once a baseline blood …

When We’Re All Together, The Patient Knows It: Creating An Interdisciplinary Learning Community In Palliative Medicine, Krista M. Hirschmann Phd, Daniel Ray Md, Elissa Foster Phd

Department of Medicine

No abstract provided.

Role Of Angiotensin Converting Enzyme 2 (Ace2) In Obesity-Associated Hypertension, Manisha Gupte

University of Kentucky Doctoral Dissertations

The purpose of this research was to determine whether adipocytes express ACE2 and its role in obesity-associated hypertension with diet-induced obesity.

To determine if ACE2 was expressed in adipose tissue and its regulation in the setting of diet-induced obesity, we fed male mice either a low fat (LF) or high fat (HF) diet acutely (1 week) or chronically ( 4 months). We demonstrated that ACE2 was regulated specifically in adipose tissue with consumption of a HF diet. However, with chronic HF feeding adipose ACE2 was dysregulated resulting in activation of the systemic RAS and increased blood pressure.

To determine the …

The Role Of The Nr4a Orphan Nuclear Receptor Nor1 In Vascular Cells And Atherosclerosis, Yue Zhao

University of Kentucky Doctoral Dissertations

The neuron-derived orphan receptor 1 (NOR1) belongs to the NR4A nuclear receptor subfamily. As an immediate early response gene, NOR1 is rapidly induced by a broad spectrum of physiological and pathological signals. Functional studies demonstrate NOR1 as a constitutively active ligand-independent nuclear receptor whose transcriptional activity is dependent on both expression level and posttranslational modifications. To date, an increasing number of studies have demonstrated a pivotal role of NOR1 in the transcriptional control of metabolism and the development of cardiovascular diseases.

In this dissertation, we demonstrate NOR1 expression in endothelial cells and sub-endothelial cells of human atherosclerotic lesions. In response …

Androgen Increases Angiotensin Receptor Type 1a On Smooth Muscle Cells To Promote Angiotensin Ii-Induced Abdominal Aortic Aneurysms, Xuan Zhang

University of Kentucky Doctoral Dissertations

The purpose of this study was to determine whether androgen promotes AT1aR expression on smooth muscle to confer high prevalence of AngII-induced AAAs in hyperlipidemic mice. In addition, we also investigate the role of androgen in the progression of established AngII-induced AAAs.

First, we sought to examine the role of endogenous androgen in the growth of established AngII-induced AAAs. By castrating male mice, we demonstrated that removal of endogenous androgen significantly decreased the progressive lumen dilation of established AngII-induced AAAs in male ApoE-/- mice, but had no effect on external AAA diameters. These results suggest that androgen contributes to the …

Altered Leptin Signaling On Dendritic Cells As A Potential Mechanism For Cancer Immunotherapy, Lorena Y. De Los Santos

Open Access Theses & Dissertations

Leptin is a pleiotropic hormone synthesized primarily by white adipocytes and its receptors are expressed in a variety of tissues and cells such as in the hypothalamus and cells of the immune system. Multiple cell types can produce a considerable amount of leptin such as skeletal muscle, placenta, and osteoblasts to name a few and its synthesis has been shown to be regulated by sex hormones and a broad range of inflammatory mediators. Although leptin has been shown to directly affect immune response, we are interested in how leptin affects dendritic cell function and their ability to induce a proper …

Development Of A Novel Metallo-Lipid Microparticle Delivery System For A Leishmania Mexicana Dna Vaccine Candidate, Joanna B. Valencia

Open Access Theses & Dissertations

ABSTRACT

Background and Significance.

The leishmaniases are an important group of neglected tropical parasitic diseases caused by parasitic protozoa of the genus Leishmania. International health authorities estimate that 350 million people around the world are at risk for contracting leishmaniasis. Two million new cases occur each year and 12 million people are presently infected worldwide. Leishmaniasis is endemic throughout the Americas region including all of Central America, most of South America, Mexico and southern Texas. Leishmania is also considered a threat to the military readiness of U.S. troops deployed to the Middle East or Latin America.

First- and second-line treatments …