Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (2555)
- TÜBİTAK (641)
- University of Kentucky (292)
- University of Nebraska - Lincoln (157)
- Thomas Jefferson University (137)
-
- Marshall University (120)
- LSU Health New Orleans (116)
- Chulalongkorn University (115)
- University of Alabama at Birmingham (91)
- Edith Cowan University (81)
- General Organization of Teaching Hospitals and Institutes (GOTHI) (76)
- Universitas Indonesia (73)
- Loma Linda University (66)
- Dartmouth College (55)
- University of Nevada, Las Vegas (52)
- China Medical University (50)
- University of Nebraska Medical Center (49)
- Old Dominion University (48)
- Touro College and University System (43)
- Virginia Commonwealth University (41)
- Aga Khan University (38)
- University of South Carolina (37)
- University of Tennessee Health Science Center (36)
- Children's Mercy Kansas City (33)
- University of Texas Rio Grande Valley (32)
- Wright State University (32)
- Liberty University (31)
- Technological University Dublin (31)
- University of Louisville (31)
- Valparaiso University (31)
- Keyword
-
- Humans (1713)
- Female (809)
- Male (734)
- Animals (598)
- Mice (400)
-
- Adult (376)
- Child (354)
- Obesity (341)
- Middle Aged (327)
- Aged (275)
- Adolescent (223)
- Infant (179)
- Diet (178)
- Inflammation (168)
- Diabetes Mellitus (164)
- Risk Factors (162)
- Biomarkers (149)
- Retrospective Studies (134)
- Child, Preschool (127)
- Pregnancy (127)
- United States (127)
- Preschool (123)
- Metabolism (116)
- Mice, Inbred C57BL (114)
- Inbred C57BL (111)
- Prospective Studies (110)
- Cross-Sectional Studies (109)
- Newborn (108)
- Diabetes Mellitus, Type 2 (107)
- Type 2 (107)
- Publication Year
- Publication
-
- Faculty, Staff and Students Publications (1149)
- Faculty, Staff and Student Publications (885)
- Turkish Journal of Medical Sciences (641)
- Children’s Nutrition Research Center Staff Publications (414)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (110)
-
- Pharmacology and Nutritional Sciences Faculty Publications (96)
- All ETDs from UAB (91)
- Journal of Medicine in Scientific Research (76)
- Loma Linda University Electronic Theses, Dissertations & Projects (63)
- Jurnal Epidemiologi Kesehatan Indonesia (56)
- Dartmouth Scholarship (53)
- School of Medicine Faculty Publications (53)
- Theses and Dissertations (51)
- BioMedicine (50)
- Food for Health: Publications (47)
- Research outputs 2022 to 2026 (42)
- Electronic Theses and Dissertations (39)
- Theses, Dissertations and Capstones (37)
- Biochemistry and Microbiology (33)
- School of Veterinary and Biomedical Sciences: Faculty Publications (33)
- Theses and Dissertations (ETD) (33)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (33)
- Historical Faculty Publications (32)
- Manuscripts, Articles, Book Chapters and Other Papers (31)
- Journal of Mind and Medical Sciences (30)
- Research outputs 2014 to 2021 (30)
- Duncan NRI Faculty and Staff Publications (27)
- Senior Honors Theses (27)
- Articles (25)
- Chemistry Faculty Publications (25)
- Publication Type
- File Type
Articles 5641 - 5670 of 6261
Full-Text Articles in Entire DC Network
Effects Of Adipocyte Deficiency Of Angiotensin Type 1a Receptors In Models Of Obesity And Hypercholesterolemia, Kelly Anne Putnam
Effects Of Adipocyte Deficiency Of Angiotensin Type 1a Receptors In Models Of Obesity And Hypercholesterolemia, Kelly Anne Putnam
Theses and Dissertations--Nutritional Sciences
Adipocytes express angiotensin II (AngII) receptors; however the direct effects of AngII at the adipocyte remain unclear. Knockout mouse models of renin-angiotensin system components exhibit reduced body weight, reduced adiposity, improved glucose tolerance, and improved blood pressure when fed high fat diets, which may be due to reduced action of AngII through the AT1aR in adipocytes. Additionally, hypercholesterolemic AT1aR deficient mice are protected from AngII-induced increases in atherosclerosis and abdominal aortic aneurysm (AAA) formation. We hypothesized that deficiency of AT1aR in adipocytes would reduce the development of obesity, obesity-induced disorders, and vascular diseases. To test this hypothesis, we created a …
The Relationship Between Symptoms And The Results Of The Skin Prick Test In Patients With Allergic Rhinitis, Hayri̇ye Karabulut, Emre Günbey, Mehmet Ali̇ Babademez, Baran Acar, Emrah Çeli̇k, Tevfi̇k Pinar, Riza Murat Karaşen
The Relationship Between Symptoms And The Results Of The Skin Prick Test In Patients With Allergic Rhinitis, Hayri̇ye Karabulut, Emre Günbey, Mehmet Ali̇ Babademez, Baran Acar, Emrah Çeli̇k, Tevfi̇k Pinar, Riza Murat Karaşen
Turkish Journal of Medical Sciences
To determine the relationship between skin prick test results and allergic symptoms and to discover which symptom or symptoms are more commonly associated with the skin prick test. Materials and methods: Of the 1462 patients with a prediagnosis of allergic rhinitis (AR) who underwent the skin prick test, 495 subjects completed the symptoms inquiry form and were included in the study. Results: Out of 495 cases, the skin prick test was found to be positive in 358 and negative in 137. No significant relationship was found between sneezing, runny nose, itchy nose, nasal obstruction, headache, postnasal drip, and skin prick …
Infant Mortality In Northeastern Anatolia And Associated Factors, Serhat Vançeli̇k, Memet Işik, Ahmet Ruhi̇ Toraman, Zekeri̇ya Aktürk
Infant Mortality In Northeastern Anatolia And Associated Factors, Serhat Vançeli̇k, Memet Işik, Ahmet Ruhi̇ Toraman, Zekeri̇ya Aktürk
Turkish Journal of Medical Sciences
To explore the causes of infant mortality. Infant mortality is the most important criterion for the evaluation of the sufficiency of mother and child health care and the planning of health care provision. In this study, we investigated infant mortality and associated factors in 7 provinces located in northeastern Turkey. The main outcome of this study was reasons for neonatal mortality. Materials and methods: We created a cross-sectional study and included all babies born in the year 2009 who died during the first 365 days of life. Data were collected from the primary care providers. A data collection form was …
The Effect Of Soya Bean Meal On Tibial Articular Cartilage Growth In Mice After Suckling Period: A Histomorphometric And Biochemical Study, Simin Fazelipour, Seyed Babak Kiaei, Amir Hossein Eghtesad, Zahra Tootian
The Effect Of Soya Bean Meal On Tibial Articular Cartilage Growth In Mice After Suckling Period: A Histomorphometric And Biochemical Study, Simin Fazelipour, Seyed Babak Kiaei, Amir Hossein Eghtesad, Zahra Tootian
Turkish Journal of Medical Sciences
To examine the effects of an oral supplement of soya bean meal on the histomorphometric alteration of tibia cartilage and the serum levels of calcium and alkaline phosphatase in 3-week-old female mice using a computer-assisted histomorphometric method. Materials and methods: Forty immature BALB/c female mice were selected and divided into 4 groups. They were fed for 3 months with 4 different regimens: a low-protein regimen without soya bean meal, 23% protein without soya bean meal, 20% of the total protein being provided by soya bean meal, and 40% of the total protein being provided by soya bean meal. After 3 …
Dietary Boron Intake Does Not Change The Ischemic Tolerance And Preconditioning Response In Isoproterenol-Induced Myocardial Injury In Healthy Rats, Mehmet Fati̇h Karakaş, Mustafa Kurt, Uğur Arslantaş, Göktürk İpek, Esra Karakaş, Emi̇ne Bi̇len, Hüsametti̇n Erdamar
Dietary Boron Intake Does Not Change The Ischemic Tolerance And Preconditioning Response In Isoproterenol-Induced Myocardial Injury In Healthy Rats, Mehmet Fati̇h Karakaş, Mustafa Kurt, Uğur Arslantaş, Göktürk İpek, Esra Karakaş, Emi̇ne Bi̇len, Hüsametti̇n Erdamar
Turkish Journal of Medical Sciences
Boron is important for many enzymes, most of which also have a role in the ischemic tolerance of the myocardium. We aimed to evaluate the influence of dietary boron intake on ischemic tolerance in a rat model. Materials and methods: Rats were divided into 3 groups according to the ischemia protocol: Sham (S) (n = 20 total), ischemia only (Isc-only) (n = 40 total), and remote ischemic preconditioning + ischemia (RIPC+Isc) (n = 40 total) groups. These 3 groups were further divided into 4 according to the amount of daily dietary boron (
The Role Of Hba1c As A Screening And Diagnostic Test For Diabetes Mellitus In Ankara, Zeynep Gi̇ni̇ş, Gülfer Öztürk, Rana Sirmali, Ali̇ Yalçindağ, Yakup Dülgeroğlu, Tuncay Deli̇başi, Namik Deli̇baş
The Role Of Hba1c As A Screening And Diagnostic Test For Diabetes Mellitus In Ankara, Zeynep Gi̇ni̇ş, Gülfer Öztürk, Rana Sirmali, Ali̇ Yalçindağ, Yakup Dülgeroğlu, Tuncay Deli̇başi, Namik Deli̇baş
Turkish Journal of Medical Sciences
This study investigated the value of HbA1c as a screening and diagnostic test for diabetes mellitus (DM) in high-risk Turkish individuals. Materials and methods: A total of 295 participants were successfully screened. Patients were divided into 4 groups based on their oral glucose tolerance test results, according to criteria put forth by the American Diabetes Association; 120 (40.7%) had normoglycemia, 44 (14.9%) had DM, 62 (21%) had impaired fasting glucose, and 69 (23.4%) had impaired glucose tolerance. Results: With a cut-off value for the diagnosis of DM of 6.1%, HbA1c had a sensitivity of 81.8% and a specificity of 80%, …
Effects Of Lycopene On Plasma Glucose, Insulin Levels, Oxidative Stress, And Body Weights Of Streptozotocin-Induced Diabetic Rats, Muhsi̇n Aydin, Sefa Çeli̇k
Effects Of Lycopene On Plasma Glucose, Insulin Levels, Oxidative Stress, And Body Weights Of Streptozotocin-Induced Diabetic Rats, Muhsi̇n Aydin, Sefa Çeli̇k
Turkish Journal of Medical Sciences
To determine possible therapeutic effects of oral lycopene supplementation on plasma insulin levels, lipid peroxidation, blood glucose levels, and the antioxidant defense system of streptozotocin-induced diabetic rats. Materials and methods: Classical biochemical methods were used to determine plasma malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Enzyme-linked immunosorbent assay was used to determine plasma insulin levels and reverse transcriptase-polymerase chain reaction was used to determine the levels of brain antioxidant enzymes (SOD, CAT, and GSH-Px). Results: It was found that the diabetes-related increase in blood glucose levels was reduced by supplementation …
Cytological Analysis Of The Oral Cells Of Chronic Renal Failure Patients: A Cytomorphometric Study, Ümmühan Tozoğlu, Mustafa Keleş, Deni̇z Ünal, Abdullah Uyanik
Cytological Analysis Of The Oral Cells Of Chronic Renal Failure Patients: A Cytomorphometric Study, Ümmühan Tozoğlu, Mustafa Keleş, Deni̇z Ünal, Abdullah Uyanik
Turkish Journal of Medical Sciences
The aim of this study was to cytologically analyze the tongue mucosa, buccal mucosa, and floor of the mouth of patients with chronic renal failure and healthy volunteers to determine what cellular changes are caused by uremic diseases. Materials and methods: In order to evaluate cellular changes induced by chronic renal failure, exfoliative cytology was used for the analysis of the tongue mucosa, buccal mucosa, and floor of the mouth of 20 uremic patients with chronic renal failure and 20 healthy volunteers. Smears from each individual were stained using the Papanicolaou method and were analyzed using a stereological method. Results: …
Nutritional Assessment Via Anthropometric And Biochemical Measurements With Stable Copd, Mehmet Meral, Ömer Araz, Eli̇f Yilmazel Uçar, Nusret Yilmaz, Ni̇hal Arzu Mi̇ri̇ci̇
Nutritional Assessment Via Anthropometric And Biochemical Measurements With Stable Copd, Mehmet Meral, Ömer Araz, Eli̇f Yilmazel Uçar, Nusret Yilmaz, Ni̇hal Arzu Mi̇ri̇ci̇
Turkish Journal of Medical Sciences
Nutritional assessment is important for the management of chronic obstructive pulmonary disease (COPD). This study aims at investigating the relation between the anthropometric and biochemical parameters for nutritional assessment with pulmonary function tests in COPD. Materials and methods: This is a prospective, cross-sectional study. Thirty-nine patients with stable COPD were enrolled the study. We evaluated the anthropometric [body mass index (BMI), skinfold thickness (SFT), and arm muscle circumference (AMC)], biochemical [serum total protein, albumin, transferrin, and blood urea nitrogen (BUN)], and spirometric [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC] measurements, as well as …
Can We Predict The Duration Of Respiratory Support In Transient Tachypnea Of The Newborn?, Osman Özteki̇n, Sali̇h Kalay, Gönül Tezel, Mustafa Akçakuş, Ni̇hal Oygür
Can We Predict The Duration Of Respiratory Support In Transient Tachypnea Of The Newborn?, Osman Özteki̇n, Sali̇h Kalay, Gönül Tezel, Mustafa Akçakuş, Ni̇hal Oygür
Turkish Journal of Medical Sciences
To assess arterial blood gas values and respiratory rates during transient tachypnea of the newborn detected in the first hour of postnatal life, and to investigate whether any of these parameters can be a good predictor of the duration of respiratory support. Materials and methods: Data were collected from the charts of newborns with a gestation of >=37 weeks born in our hospital and admitted to our neonatal intensive care unit with a diagnosis of transient tachypnea of the newborn between January 2007 and December 2009. Patients with respiratory support of >=5 days were accepted as group A and those …
Evaluation Of Vitamin B-12 Level In Middle-Aged Obese Women With Metabolic And Non-Metabolic Syndrome: Case-Control Study, Davut Baltaci, Ali̇ Kutlucan, Serkan Öztürk, İsmai̇l Karabulut, Hayri̇ye Ak Yildirim, Ahmet Çeler, Gökhan Celbek, İsmai̇l Hamdi̇ Kara
Evaluation Of Vitamin B-12 Level In Middle-Aged Obese Women With Metabolic And Non-Metabolic Syndrome: Case-Control Study, Davut Baltaci, Ali̇ Kutlucan, Serkan Öztürk, İsmai̇l Karabulut, Hayri̇ye Ak Yildirim, Ahmet Çeler, Gökhan Celbek, İsmai̇l Hamdi̇ Kara
Turkish Journal of Medical Sciences
To investigate the correlation between vitamin B12 and body mass index (BMI) along with insulin resistance (IR) in middle-aged obese women. Materials and methods: The study was designed as a case-control study. The study group included middle-aged obese women and the control group included aged-matched lean women. Weight, height, and hip and waist circumferences were measured. Biochemical parameters such as fasting and postprandial glucose, vitamin B12 and folic acid levels, and lipid profiles were assayed. Results: Enrolled in the study were 116 middle-aged obese and 103 aged-matched healthy lean women. The vitamin B12 level of the obese women was significantly …
Evaluation Of The Antibacterial Activity Of Zataria Multiflora Boiss., Rhus Coriaria L. (Sumac), Mentha Piperita L., And Ocimum Basilicum L. Extracts On Brucella Strains Isolated From Brucellosis Patients, Yousef Motaharinia, Mohammad Ali Rezaee, Mohammad Saleh Hazhir, Farid Zandi, Reza Shapouri, Mohammad Saied Hakhamaneshi, Ahmad Rashidi, Mohammad Reza Rahmani
Evaluation Of The Antibacterial Activity Of Zataria Multiflora Boiss., Rhus Coriaria L. (Sumac), Mentha Piperita L., And Ocimum Basilicum L. Extracts On Brucella Strains Isolated From Brucellosis Patients, Yousef Motaharinia, Mohammad Ali Rezaee, Mohammad Saleh Hazhir, Farid Zandi, Reza Shapouri, Mohammad Saied Hakhamaneshi, Ahmad Rashidi, Mohammad Reza Rahmani
Turkish Journal of Medical Sciences
Since brucellosis has been called a chronic illness and treatment of patients infected with this bacterium has not been successful, the present study aim ed to evaluate the effects of several medicinal plant extracts on clinical Brucella strains. Materials and methods: First, Brucella strains were isolated from brucellosis patients. Then an antibiotic resistance assay was performed for these strains, while the antibacterial activity of the above-mentioned extracts was evaluated. Results: After performing accurate evaluations, the obtained results showed that all of the isolated Brucella strains were sensitive to tetracycline, doxycycline, and gentamicin, and the rates of antibiotic resistance to rifampin …
Prevalence And Etiology Of Anemias In The Adult Turkish Population, Ramazan Memi̇şoğullari, Hayri̇ye Ak Yildirim, Taner Uçgun, Meli̇h Engi̇n Erkan, Cemaletti̇n Güneş, Mesut Erbaş, Adem Güngör, Mehmet Emi̇n Yanik
Prevalence And Etiology Of Anemias In The Adult Turkish Population, Ramazan Memi̇şoğullari, Hayri̇ye Ak Yildirim, Taner Uçgun, Meli̇h Engi̇n Erkan, Cemaletti̇n Güneş, Mesut Erbaş, Adem Güngör, Mehmet Emi̇n Yanik
Turkish Journal of Medical Sciences
Anemia is common in the general population and one of the most frequently observed nutritional deficiency diseases in the world today. The aim of this study was to investigate the prevalence and etiology of anemias in a large cohort representing the Turkish nation. Materials and methods: The study population comprised 2187 subjects. Serum iron, iron binding capacity, ferritin, vitamin B12, and folic acid analyses were conducted with autoanalyzers using commercial kits. Results: A total of 565 (25.8%) subjects (423 females and 142 males) were diagnosed as anemic. The prevalence of anemia was 30.0% in female and 18.2% in male participants. …
The Oral Health Status Of Healthy And Obese Children In A Turkish Population: A Cross-Sectional Study, Günseli̇ Güven Polat, Sevi̇ Burçak Çehreli̇, Mehmet Emre Taşcilar, Özlem Marti Akgün, Ceyhan Altun, İlker Tolga Özgen
The Oral Health Status Of Healthy And Obese Children In A Turkish Population: A Cross-Sectional Study, Günseli̇ Güven Polat, Sevi̇ Burçak Çehreli̇, Mehmet Emre Taşcilar, Özlem Marti Akgün, Ceyhan Altun, İlker Tolga Özgen
Turkish Journal of Medical Sciences
To compare the oral health status of a group of obese and healthy Turkish children. Materials and methods: The study involved 43 healthy (19 boys and 24 girls, mean age: 9.88) and 53 obese (18 boys and 35 girls, mean age: 10.4) children who were admitted to a pediatric dentistry clinic in 2008 and 2009. The parents were asked to complete a questionnaire concerning medical history and dietary/oral hygiene habits. The number of decayed, missing, and filled permanent teeth (DMFT); number of decayed, missing, and filled primary teeth (dmft); and gingival bleeding index (GBI) scores of patients were recorded. Statistical …
Penetrating Chest Injuries: Analysis Of 99 Cases, Ülkü Yazici, Alkin Yazicioğlu, Ertan Aydin, Koray Aydoğdu, Sadi̇ Kaya, Nuretti̇n Karaoğlanoğlu
Penetrating Chest Injuries: Analysis Of 99 Cases, Ülkü Yazici, Alkin Yazicioğlu, Ertan Aydin, Koray Aydoğdu, Sadi̇ Kaya, Nuretti̇n Karaoğlanoğlu
Turkish Journal of Medical Sciences
To investigate the patterns of penetrating thoracic injuries and techniques used in their management, and to contribute further data on the knowledge of penetrating thoracic trauma. Materials and methods: The records were reviewed of 99 patients seen at our thoracic surgery hospital over a 4-year period. Results: The group comprised 90 male (90.9%) and 9 female (9.1%) patients, with a mean age of 29.0 years. Of these patients, 62 (62.6%) had left-sided, 33 (33.3%) had right-sided, and 4 (4%) had bilateral penetrating injury. Stab wounds comprised 89 cases (89.9%) and the remaining 10 patients (10.1%) suffered gunshot wounds. Intercostal tube …
The Impact Of Attention Training On Children With Low Vision: A Randomized Trial, Bi̇lge Başakci Çalik, Ali̇ Ki̇ti̇ş, Uğur Cavlak, Atti̇la Oğuzhanoğlu
The Impact Of Attention Training On Children With Low Vision: A Randomized Trial, Bi̇lge Başakci Çalik, Ali̇ Ki̇ti̇ş, Uğur Cavlak, Atti̇la Oğuzhanoğlu
Turkish Journal of Medical Sciences
The purpose of this study was to show the effectiveness of a 6-week attention training program on the cognition, quality of life (QOL), and activities of daily living in children with low vision. Materials and methods: Included in this study were 20 children with low vision, aged 7-12 years. The children were divided into 2 groups. While the first group (n = 10) participated in a 6-week Pay Attention© training program 3 times a week for 30 min, the second group (n = 10) was the control. Before and after the program, all of the participants were evaluated using a …
Risk Factors For Mortality In Patients With Nosocomial Staphylococcus Aureus Bacteremia, Ali̇ye Baştuğ, Gülruhsar Yilmaz, Bi̇rcan Kayaaslan, Esragül Akinci, Hurrem Bodur
Risk Factors For Mortality In Patients With Nosocomial Staphylococcus Aureus Bacteremia, Ali̇ye Baştuğ, Gülruhsar Yilmaz, Bi̇rcan Kayaaslan, Esragül Akinci, Hurrem Bodur
Turkish Journal of Medical Sciences
Bloodstream infections (BSIs) due to Staphylococcus aureus have become increasingly common in hospitals worldwide. The aim of this study was to evaluate the risk factors for mortality of nosocomial BSI due to S. aureus. Materials and methods: We analyzed risk factors for mortality of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) bacteremia in a prospective case control study in a 1196-bed tertiary referral medical center. Logistic regression analyses were used to determine risk factors and prognostic factors of mortality. Results: Between July 2006 and January 2009, 176 patients were identified with clinically significant and microbiologically confirmed nosocomial bacteremia …
Comparison Of The Effects Of Intradialytic Parenteral Nutrition Alone And Combined With Anabolic Steroid In Patients Undergoing Hemodialysis Therapy, Abdi̇ Meti̇n Sarikaya, Funda Sari, Ramazan Çeti̇nkaya
Comparison Of The Effects Of Intradialytic Parenteral Nutrition Alone And Combined With Anabolic Steroid In Patients Undergoing Hemodialysis Therapy, Abdi̇ Meti̇n Sarikaya, Funda Sari, Ramazan Çeti̇nkaya
Turkish Journal of Medical Sciences
It has been shown that androgen anabolic steroids and intradialytic parenteral nutrition (IDPN) may have advantages in malnourished hemodialysis patients. We aimed to compare the effects of IDPN and IDPN with added anabolic steroid. Materials and methods: Twenty hemodialysis patients who had albumin of
The Epigenetic Regulation Of Cubilin And The Physiological Role Of This Receptor In Maintaining The Homeostasis Of Serum Albumin And Hdl, Sayed Obaidullah Aseem
The Epigenetic Regulation Of Cubilin And The Physiological Role Of This Receptor In Maintaining The Homeostasis Of Serum Albumin And Hdl, Sayed Obaidullah Aseem
MUSC Theses and Dissertations
Cubilin is an endocytic receptor capable of mediating the endocytosis of multiple ligands including High Density Lipoprotein apolipoprotein A-I (apoA-1) and albumin. It is highly expressed on the epithelium of intestinal villi and renal proximal tubules. In the kidney, endocytosis mediated by cubilin and its co-receptor megalin is the principal mechanism for proximal tubule reabsorption of filtered proteins, such as albumin and apoA-1. Yet, the consequences of cubilin deficiency on the blood levels of albumin and apoA-1 have not been studied. Furthermore, cubilin is downregulated in chronic diseases such as diabetes. However, little is known about the regulation of cubilin …
Structural Characterization Of A Conserved, Calcium-Dependent Periplasmic Protease From Legionella Pneumophila, Debashree Chatterjee, Chelsea D. Boyd, George A. O'Toole, Holger Sondermann
Structural Characterization Of A Conserved, Calcium-Dependent Periplasmic Protease From Legionella Pneumophila, Debashree Chatterjee, Chelsea D. Boyd, George A. O'Toole, Holger Sondermann
Dartmouth Scholarship
The bacterial dinucleotide second messenger c-di-GMP has emerged as a central molecule in regulating bacterial behavior, including motility and biofilm formation. Proteins for the synthesis and degradation of c-di-GMP and effectors for its signal transmission are widely used in the bacterial domain. Previous work established the GGDEF-EAL domain-containing receptor LapD as a central switch in Pseudomonas fluorescens cell adhesion. LapD senses c-di-GMP inside the cytosol and relays this signal to the outside by the differential recruitment of the periplasmic protease LapG. Here we identify the core components of an orthologous system in Legionella pneumophila. Despite only moderate sequence conservation at …
Sterol Lipid Metabolism In Down Syndrome Revisited: Down Syndrome Is Associated With A Selective Reduction In Serum Brassicasterol Levels, Gavin Tansley, Daniel T. Holmes, Dieter Lütjohann, Elizabeth Head, Cheryl L. Wellington
Sterol Lipid Metabolism In Down Syndrome Revisited: Down Syndrome Is Associated With A Selective Reduction In Serum Brassicasterol Levels, Gavin Tansley, Daniel T. Holmes, Dieter Lütjohann, Elizabeth Head, Cheryl L. Wellington
Pharmacology and Nutritional Sciences Faculty Publications
Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer's Disease (AD). A better understanding of sterol lipid metabolism in individuals with Down Syndrome (DS) may help elucidate how this population's unique metabolic characteristics influence their risks for atherosclerosis and AD. To revisit the question of whether sterol lipid parameters may be altered in DS subjects, we performed a pilot study to assess traditional serum sterol lipids and lipoproteins, as well as markers of sterol biosynthesis, metabolites, and plant sterols in 20 subjects with …
Aging And Down Syndrome, Elizabeth Head, Wayne Silverman, David Patterson, Ira T. Lott
Aging And Down Syndrome, Elizabeth Head, Wayne Silverman, David Patterson, Ira T. Lott
Pharmacology and Nutritional Sciences Faculty Publications
No abstract provided.
Characterisation Of Crataegus Monogyna Fractions And Assessment Of Their Functional Properties, Eilish Shortle
Characterisation Of Crataegus Monogyna Fractions And Assessment Of Their Functional Properties, Eilish Shortle
Theses
Hawthorn {Crataegus monogyna) is a herb that has been used medicinally since ancient times. In modern medicine it is known for its cardiotonic properties and is used as a cardiovascular protective, hypotensive and hypocholesterolemic agent. In recent years supercritical fluid extraction (SFE) has become more popular as an extraction method for botanical material as it is an environmentally-friendly method that can produce toxic-free extracts. The optimal SFE extraction conditions for the extraction of antioxidant compounds from both, hawthorn leaf & dower and hawthorn berries, using carbon dioxide, were determined in this study. The optimized extracts were then compared to pre-prepared …
The Perfect Food For Perfect Health And Pleasure?, Cem Ekmekçi̇oğlu
The Perfect Food For Perfect Health And Pleasure?, Cem Ekmekçi̇oğlu
Turkish Journal of Medical Sciences
How perfect a food or meal is depends on hedonic and nutritional factors. The hedonic component is influenced by all of our 5 senses. In addition, social, environmental, and cognitive/experiential factors may have an effect on our attitude towards a food. On the other hand, nutrient composition and content, as well as bioavailability, determine how nutritionally perfect a food is. So, does the perfect food exist? What makes a food or a meal perfect? This paper will try to answer these questions by briefly discussing the most important variables.
The Effect Of Omega-3 Fatty Acid Supplementation On Plasma Orexin A, Plasma Fatty Acids, And Anthropometric Measurements In Patients With Narcolepsy, Makbule Gezmen Karadağ, Meral Aksoy
The Effect Of Omega-3 Fatty Acid Supplementation On Plasma Orexin A, Plasma Fatty Acids, And Anthropometric Measurements In Patients With Narcolepsy, Makbule Gezmen Karadağ, Meral Aksoy
Turkish Journal of Medical Sciences
To determine the effect of omega-3 (n-3) fatty acid supplementation on plasma orexin A, plasma fatty acids, and anthropometric measurements in patients with narcolepsy. Materials and methods: The study was performed on 17 males with narcolepsy and 14 healthy males between the ages of 21-55. An n-3 fatty acid supplement of 1.4 g/day was administered to the groups for 2 months. The anthropometric measurements of the individuals were taken at the onset and the end of trial, and orexin, fatty acids, and other biochemical parameters in the plasma were analyzed. Results: While there was no statistically significant change in anthropometric …
Determination Of Changes In The Basal Metabolic Rate And Body Composition Of Patients With Chronic Active And Inactive Hepatitis B Infection Using Bioelectrical Impedance Analysis*, Gökhan Unutmaz, Süda Teki̇n Koruk, Cemi̇l Sert
Determination Of Changes In The Basal Metabolic Rate And Body Composition Of Patients With Chronic Active And Inactive Hepatitis B Infection Using Bioelectrical Impedance Analysis*, Gökhan Unutmaz, Süda Teki̇n Koruk, Cemi̇l Sert
Turkish Journal of Medical Sciences
To examine changes in the basal metabolic rate and body composition of patients with chronic inactive and active hepatitis B (HBV) infection as measured using single frequency bioelectrical impedance analysis (BIA) and to investigate the convenience of this method for follow-up with these patients. Materials and methods: Twenty patients with chronic inactive HBV infection, 22 with chronic active HBV infection, and 43 healthy subjects were enrolled in the study. Using single frequency BIA and basal metabolic rate (BMR), the resistance and body composition of all participants were measured. Results: A total of 85 subjects (31 female and 54 male) with …
Oxidative Stress Status Of Individuals Involved In Traffic Accidents*, Bora Özdemi̇r, Atilhan Kaya, Özgür Söğüt, Hali̇l Kaya, Mehmet Tahi̇r Gökdemi̇r, Osman Celbi̇ş
Oxidative Stress Status Of Individuals Involved In Traffic Accidents*, Bora Özdemi̇r, Atilhan Kaya, Özgür Söğüt, Hali̇l Kaya, Mehmet Tahi̇r Gökdemi̇r, Osman Celbi̇ş
Turkish Journal of Medical Sciences
To investigate the role of the oxidative stress status of drivers involved in traffic accidents as a risk factor. Materials and methods: Twenty-six drivers and 28 passengers involved in traffic accidents and 31 healthy control drivers and 30 healthy control pedestrians were enrolled in the present study. The total antioxidant status (TAS) and total oxidant status (TOS) were measured in blood samples. Results: The mean value of the TOS level in drivers involved in traffic accidents was significantly higher than that of the control pedestrians (P =< 0.05). The mean value of the TAS level in passengers involved in traffic accidents was significantly lower than that of the control drivers and pedestrians (P =< 0.001 and P =< 0.01, respectively). Conclusion: This is the first study assessing the oxidative markers of individuals involved in a traffic accident compared with a control group. The results reveal that involvement in a traffic accident has an effect on oxidative markers. However, further studies are required in order to use the oxidative stress status of drivers involved in traffic accidents as a marker for estimating the accident risk.
Associated Organ Injuries In Pancreatic Injuries, Morbidity, And Mortality, Akin Önder, Metehan Gümüş, Murat Kapan, Abdullah Böyük, Zülfü Arikanoğlu, Sadullah Gi̇rgi̇n
Associated Organ Injuries In Pancreatic Injuries, Morbidity, And Mortality, Akin Önder, Metehan Gümüş, Murat Kapan, Abdullah Böyük, Zülfü Arikanoğlu, Sadullah Gi̇rgi̇n
Turkish Journal of Medical Sciences
Aim: Pancreatic injuries are rarely seen due to the retroperitoneal location of the organ. Associated organ and vascular structures usually accompany injury. In this study, the effect of ductal injury and associated organ injuries on morbidity and mortality was investigated. Materials and methods: Between January 2004 and October 2010, 26 patients with abdominal trauma who developed pancreatic injury and underwent surgery at the Dicle University General Surgery Department were evaluated retrospectively. Results: Of the 26 patients, 20 were males (76.9%) and 6 (23.1%) were females. The mean age of the patients was 24.96 ± 9.4 (14-56) years. Of the injuries, …
Oral Findings In Children With Celiac Disease, Vi̇ldan Erteki̇n, Muhammed Aki̇f Sümbüllü, Mahya Sultan Tosun, Mukadder Ayşe Seli̇moğlu, Mustafa Kara, Ni̇hat Kiliç
Oral Findings In Children With Celiac Disease, Vi̇ldan Erteki̇n, Muhammed Aki̇f Sümbüllü, Mahya Sultan Tosun, Mukadder Ayşe Seli̇moğlu, Mustafa Kara, Ni̇hat Kiliç
Turkish Journal of Medical Sciences
Aim: To investigate whether Turkish children with celiac disease (CD) show dental enamel defects (DEDs), recurrent aphthous stomatitis (RAS), teeth missing, and xerostomia, and to compare the results with age- and sex-matched healthy children. Materials and methods: The oral cavity was explored in 81 patients with CD (mean age 8.7 ± 3.7 years; age range 2.5 to 17 years) and in 20 healthy controls. Enamel defects, teeth missing, RAS, and xerostomia were established. Results: Forty-three (53.1%) celiac patients and 5 (25%) control subjects had enamel defects. Enamel defects occurred more frequently in patients (P = 0.025) compared to controls. Regarding …
Investigation Of Serum Paraoxonase-1 Activity And Lipid Levels In Patients With Hyperthyroidism, Gülden Başkol, Kiymet Dolbun Seçki̇n, Fahri̇ Bayram, Fati̇h Tanriverdi̇
Investigation Of Serum Paraoxonase-1 Activity And Lipid Levels In Patients With Hyperthyroidism, Gülden Başkol, Kiymet Dolbun Seçki̇n, Fahri̇ Bayram, Fati̇h Tanriverdi̇
Turkish Journal of Medical Sciences
The present study was designed to investigate the relationship among the serum paraoxonase-1 (PON-1) activity, lipid levels, and thyroid hormone status in patients with hyperthyroidism. Materials and methods: The study group comprised 30 patients with primary hyperthyroidism and 18 normal healthy controls who were matched for age and sex. Serum PON-1 activity was determined by spectrophotometric methods. Results: Serum PON-1 activity was found to be lower in patients compared to controls (P < 0.05). Free triiodothyronine (T3) and free thyroxine (T4) levels were significantly higher in the patient group compared to the control group (P < 0.001 and P < 0.001 respectively). Thyroid-stimulating hormone (TSH) and total cholesterol values were found to be lower in patients than in the controls (P < 0.001 and P < 0.001 respectively). Low-density lipoprotein cholesterol levels were found to be decreased in patients compared to controls (P < 0.005). Triglyceride and high-density lipoprotein cholesterol levels were not significantly different between the 2 groups (P > 0.05). Serum PON-1 activity was found to be negatively correlated with free T4 levels (r = -0.324, P < 0.05) and positively correlated with total cholesterol (r = 0.330, P < 0.05) and TSH levels (r = 0.577, P < 0.001). Conclusion: Our PON-1 results show that there is decreased antioxidant defense in patients with hyperthyroidism. Therefore, we think that effective antioxidant therapy to increase PON-1 activity may be a therapeutic option in patients with hyperthyroidism.