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Some Variations In The Formation Of The Brachialplexus In Infants*, Ahmet Uzun, Sai̇t Bi̇lgi̇ç Jan 1999

Some Variations In The Formation Of The Brachialplexus In Infants*, Ahmet Uzun, Sai̇t Bi̇lgi̇ç

Turkish Journal of Medical Sciences

The anatomical variations of the brachial plexus in human have clinical significance to surgeons, radiologists and anatomists. We studied some variations in the formation of 130 brachial plexuses in sixty-five infant cadavers (34 males, 31 females; aged 1-7 days). The brachial plexus consisted of the 5 th , 6 th , 7 th , and 8 th cervical spinal nerves and 1 st thoracic spinal nerve (69.23%). We found that among the 130 plexuses, 30.77% also received a contribution from C4 (Fig.1, A ) . The variations in the formation of brachial plexuses were classified into three groups. Group 1 …

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Nuclear Receptor Co-Repressor Gene Localizes To 17p11.2, A Frequently Deleted Band In Malignant Disorders, Michael W. Stacey, Jianxiang Wang, Rebecca L. Byrd, Johnson M. Liu, William G. Kearns Jan 1999

Nuclear Receptor Co-Repressor Gene Localizes To 17p11.2, A Frequently Deleted Band In Malignant Disorders, Michael W. Stacey, Jianxiang Wang, Rebecca L. Byrd, Johnson M. Liu, William G. Kearns

Bioelectrics Publications

The t(8;21) between the AML1 and ETO genes is a commonly seen genetic alteration in acute myeloid leukemia. Recently, we reported that the fusion partner ETO binds to the human nuclear receptor co-repressor (NCOR), a member of the NCOR/SIN3/histone deacetylase complex. This complex mediates transcriptional repression as a result of chromatin remodeling. Here, we used a combination of fluorescence in situ hybridization and hybrid panels to localize the human NCOR gene (NCOR) to chromosome band 17p11.2. The position of human NCOR on 17p11 raises the possibility of deranged transcriptional regulation in malignant disorders associated with deletions of 17p.

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Agnors, Pcna And Histologic Activity Index Inchronic Liver Disease, Koray Ceyhan, İlkser Akpolat, İbrahim Kobat, Nazan Bozdoğan, Selim Erekul Jan 1999

Agnors, Pcna And Histologic Activity Index Inchronic Liver Disease, Koray Ceyhan, İlkser Akpolat, İbrahim Kobat, Nazan Bozdoğan, Selim Erekul

Turkish Journal of Medical Sciences

Chronic hepatitis is a clinical and pathological syndrome, which has several causes and it is characterized by varying degrees of hepatocellular necrosis and inflammation. Several systems have been proposed to evaluate the diagnosis, grading and staging of chronic hepatitis. A histologic activity index (HAI) has been developed which generates a numerical score for liver biopsy specimens obtained from patients with chronic hepatitis. The aim of this study was to evaluate the correlation between HAI and proliferative activity markers, such as PCNA and AgNORs in biopsy specimens obtained from patients with chronic liver disease including chronic hepatitis and cirrhosis. Mean AgNOR …

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Effect Of Dehydration On The Pharmacokinetics Of Mefenamic Acid, Shadab Qamar, Nadeem Irfan, Mahmood Ahmad, Muhammad Jamshaid, Naeem A. Muzaffar Jan 1999

Effect Of Dehydration On The Pharmacokinetics Of Mefenamic Acid, Shadab Qamar, Nadeem Irfan, Mahmood Ahmad, Muhammad Jamshaid, Naeem A. Muzaffar

Turkish Journal of Medical Sciences

The pharmacokinetic properties and bioavailability of mefenamic acid was studied in normal and dehydrated rabbits. High perfomance liquid chromatography (HPLC) was used for the assay of mefenamic acid in plasma samples. The mean plasma concentration and area under the plasma concentration-time curve decreased but the volume of distribution and total body clearance increased significantly (P

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A Novel Clinical And Laboratory Based Approach To Coronary Heart Disease: Relationship Between Angiography Findings, Antioxidant Enzymes And No, Bülent Sözmen, Fevzi̇ye Uysal, Dervi̇ş Gazi̇tepe, Leyla Aslan, Eser Yildirim Sözmen Jan 1999

A Novel Clinical And Laboratory Based Approach To Coronary Heart Disease: Relationship Between Angiography Findings, Antioxidant Enzymes And No, Bülent Sözmen, Fevzi̇ye Uysal, Dervi̇ş Gazi̇tepe, Leyla Aslan, Eser Yildirim Sözmen

Turkish Journal of Medical Sciences

Atherosclerosis is the most common manifestation of cardiovascular disease. However the exact mechanisms that take place in its pathogenesis have not yet been completely understood. Free radicals and lipid peroxidation may play an important role in the pathogenesis of atherosclerosis and endothelial dysfunction also may be an aggravating factor in this process. Unfortunately all of the previous studies have focused on the atherosclerotic tissue. Our aim was to establish a relationship between the antioxidant enzymes and plasma nitrate as an index of whole-body, endogenous nitric oxide production in coronary heart disease and also the relationship between these parameters and the …

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Cytogenetic And Phenotypic Findings In Turkish Patients With Fanconi's Anemia, Hati̇ce Ilgin, Ayşe Nurten Akarsu, Fatma Işik Bökesoy Jan 1999

Cytogenetic And Phenotypic Findings In Turkish Patients With Fanconi's Anemia, Hati̇ce Ilgin, Ayşe Nurten Akarsu, Fatma Işik Bökesoy

Turkish Journal of Medical Sciences

Fanconi's anemia is an autosomal recessive disorder with manifestation of chromosomal instability inducible by alkylating agents. Since 1989 we studied 85 patients with suspected Fanconi's anemia (FA) to confirm diagnosis. Cytogenetic analyses were performed on spontaneous and induced cultures of peripheral blood samples. Induction was carried with mitomycin-C (MMC) or diepoxybutane (DEB). The normal range of spontaneous, MMC and DEB-induced breaks were 0.00-0.10, 0.00-0.16 and 0.00-0.16 per cell respectively. Fanconi's anemia was confirmed when breaks were above the normal threshold. According to this criterion 59 patients were confirmed as having FA. Some of the siblings were also investigated to exclude …

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The Effect Of Race On The Exposure Of Theinternal Auditory Canal Via The Retrosigmoidapproach In Turkish Subjects, Eni̇s Alpi̇n Güneri̇, Handan Çakmakçi, Ahmet Ömer İki̇z, Keri̇m Ceryan Jan 1999

The Effect Of Race On The Exposure Of Theinternal Auditory Canal Via The Retrosigmoidapproach In Turkish Subjects, Eni̇s Alpi̇n Güneri̇, Handan Çakmakçi, Ahmet Ömer İki̇z, Keri̇m Ceryan

Turkish Journal of Medical Sciences

Hearing conservation in acoustic neuroma surgery via the retrosigmoid approach depends upon a good exposure of the internal auditory canal from behind avoiding labyrinthine injury. The accessibility is influenced largely by the individual characteristics of the temporal bone and the variability of the surgical landmarks is the result of different skull base shapes among different races. The aim of this study was to evaluate the effect of race on the exposure of the internal auditory canal of Turkish subjects via the retrosigmoid approach. Axial temporal bone CT scans of 40 Turkish individuals were studied by measuring the relevant parameters and …

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Time Dependent Changes In The Cristaneuroepithelium Resulting From Gentamicinototoxicity In The Chinchilla, Hasan Tanyeri̇, Ivan Lopez, Larry Hoffman Jan 1999

Time Dependent Changes In The Cristaneuroepithelium Resulting From Gentamicinototoxicity In The Chinchilla, Hasan Tanyeri̇, Ivan Lopez, Larry Hoffman

Turkish Journal of Medical Sciences

This experiment was conducted to investigate the time-dependent effects of gentamicin (GM) on the neuroepithelial morphology of the posterior crista ampullares (PCA) of the adult chinchilla. The time course of GM-induced HC pathology was documented through measurements of HC density as well as through HC morphologic evaluation. HC morphology was examined under light microscopy and HC density measurements were documented as a function of the time course of GM-induced ototoxicity. Six groups of animals (n=12) were treated with daily injections of 30 mg/kg of GM subcutaneously (SC) for six days and were sacrificed 1, 2, 3, 4, 6 and 8 …

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Opinions Of Assistant Doctors In Süleymandemirel University Medical Faculty Aboutstatistical Knowledge, Mustafa Öztürk, Veli̇ddi̇n Selçuk Engi̇n, Ahmet Nesi̇mi̇ Ki̇şi̇oğlu Jan 1999

Opinions Of Assistant Doctors In Süleymandemirel University Medical Faculty Aboutstatistical Knowledge, Mustafa Öztürk, Veli̇ddi̇n Selçuk Engi̇n, Ahmet Nesi̇mi̇ Ki̇şi̇oğlu

Turkish Journal of Medical Sciences

In scientific investigations; statistical knowledge is essential for collection and analysis of data properly as well as correct interpretation of literature information. In this study that was made in March 1997, opinions of 46 assistant doctors in Süleyman Demirel University Medicine Faculty about statistical knowledge were investigated by a questionnaire. All respondents have agreed on the fact that comprehension of the statistical process in an article was necessary for throughout understanding. Besides, 43 of them (93.5%) admitted that their present statistical knowledge was few or absent at all. All assistant doctors stated that a statistical education program need to be …

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Psychosomatic Symptoms In Patients With Alopecia Areata And Vitiligo, İbrahi̇m Kökçam, Nevzat Akyar, Yunus Saral, Nalan K. Oğuzhanoğlu Jan 1999

Psychosomatic Symptoms In Patients With Alopecia Areata And Vitiligo, İbrahi̇m Kökçam, Nevzat Akyar, Yunus Saral, Nalan K. Oğuzhanoğlu

Turkish Journal of Medical Sciences

Vitiligo and alopecia areata present an excellent opportunity to f ocus on the effect of impaired appearance on the lives of the persons with these diseases. Emotional stress has precipitated vitiligo and alopecia areata in some patients. Twenty-eight patients suffering from alopecia areata and vitiligo and twenty healthy persons at ages between ten and sixty underwent psychological tests of examination with special regard to verification of their psychiatric symptoms. The results were compared for all groups. The results revealed that depressive symptomatology in patients with vitiligo and alopecia areata was higher than in the control group (respectively, 55%, 36%, 15%). …

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New Frontiers In The Reperfusion Of Myocardialinfarction, Mehmet Ağirbasli, Spencer B. King Jan 1999

New Frontiers In The Reperfusion Of Myocardialinfarction, Mehmet Ağirbasli, Spencer B. King

Turkish Journal of Medical Sciences

No abstract provided.

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The Effects Of Flutamide On Lipid Profile, Insulinsensitivity, Hirsutism And Gonadotropins Inwomen With Polycystic Ovary Syndrome, Mi̇that Bahceci̇, Alpaslan Tuzcu, Mehmet Dursun, Meli̇ksah Ertem, Vahi̇t Yükselen Jan 1999

The Effects Of Flutamide On Lipid Profile, Insulinsensitivity, Hirsutism And Gonadotropins Inwomen With Polycystic Ovary Syndrome, Mi̇that Bahceci̇, Alpaslan Tuzcu, Mehmet Dursun, Meli̇ksah Ertem, Vahi̇t Yükselen

Turkish Journal of Medical Sciences

In this study, we evaluated metabolic changes and the effects of flutamide in 22 women with PCOS. Flutamide was administered for a 6-month period in a dose of 750 mg/day. The basal and after treatment body mass index, waist: hip ratio, blood glucose, insulin, lipids, Ferriman-Gallwey scoring (FGS), gonadotropins, testosterone, trasaminazed and glucose: insulin (G:I) ratio were measured. For comparison, ANOVA was used. The sixth month mean FGS was significantly lower than the basal values (18.5±7.4 and 12.5±4.5, P

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Field Sampling And Necropsy Examination Of Fish, A. S. Kane, A. Baya, R. Reimschuessel, K. M. St. Pé, C. A. Poukish, C. P. Driscoll Jan 1999

Field Sampling And Necropsy Examination Of Fish, A. S. Kane, A. Baya, R. Reimschuessel, K. M. St. Pé, C. A. Poukish, C. P. Driscoll

Virginia Journal of Science

This paper presents an overview of observational and fish sampling tech­niques for investigating fish lesions, morbidity and mortality. These sam­pling techniques and investigations are much like detective work and require attention to detail, common sense, technical proficiency and experience. To solve the mystery of a fish kill, the investigator must use available evidence and clues to piece together a series of events that often have long since passed. The cause of these field events may be chemical, biological or physical; more often, it is some combination of these. An initial categorization approach may be used to reduce the great number …

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Significance Of Cardiac Troponin T Release In Detecting Minor Myocardial Injury After Percutaneous Transluminal Coronary Angioplasty, Güli̇nnaz Alper, Taner Onat, Ömür Erkizan, Fi̇li̇z Özerkan, Azem Akilli Jan 1999

Significance Of Cardiac Troponin T Release In Detecting Minor Myocardial Injury After Percutaneous Transluminal Coronary Angioplasty, Güli̇nnaz Alper, Taner Onat, Ömür Erkizan, Fi̇li̇z Özerkan, Azem Akilli

Turkish Journal of Medical Sciences

Cardiac Troponin T (TnT) is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. This study was designed to evaluate the diagnostic efficiency of TnT enzyme immunoassay in detecting myocardial damage in patients with stable angina pectoris undergoing visually successful percutaneous transluminal coronary angioplasty (PTCA) and to compare this newly developed test with the conventionally used cardiac enzyme tests. The study population consisted of 24 patients (3 females and 21 males) with a mean age of 55±9 years. Serial blood samples …

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The Effect Of Lead Inhalation On Rat Lungmorphology, Bi̇lge Onarlioğlu, Turhan Onarlioğlu, Sena Erdal Jan 1999

The Effect Of Lead Inhalation On Rat Lungmorphology, Bi̇lge Onarlioğlu, Turhan Onarlioğlu, Sena Erdal

Turkish Journal of Medical Sciences

Lead may exert toxic effects on several organ systems, but those in the lung are the most insidious. Therefore the aim of the present study was to investigate the morphological alterations caused by lead intoxication in rat lungs. Twenty-five Wistar albino rats were divided into three groups: the control group consisted of five animals while the experimental groups contained ten animals each. The control group animals were not subjected to lead treatment, whereas the first experimental group animals were exposed to 500 \mug /0.1 m 3 /day of lead for one week, and the second group had the same dosage …

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Oxidative Damage In Erythrocytes During Cold Storage With Organ Preservation Solution, Aki̇f B. Memmedoğlu, Ahmet Özaydin, İsmai̇l Seçki̇n, Gönül Sultuybek Jan 1999

Oxidative Damage In Erythrocytes During Cold Storage With Organ Preservation Solution, Aki̇f B. Memmedoğlu, Ahmet Özaydin, İsmai̇l Seçki̇n, Gönül Sultuybek

Turkish Journal of Medical Sciences

It is known that erythrocyte aggregation in renal tissue during preserva-tion is cause of microcirculation defects in the reperfusion period. The aim of our study is to investigate oxidative damage in erythrocytes relative to the time of cold ischemia during organ preservation and relationship between lipid peroxidation and development of these damages. In experiments with a rabbit model, explanted kidneys were exposed to perfusion and 96 hours preservation with Euro-Collins (EC) in the 1st group, and University of Wisconsin (UW) solution in the 2nd group. Electron-microscopic examinations in renal tissueswere performed. Lipid peroxidation and glutathione levels in erythrocytes preserved in …

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Action Of Aspirin On Acetylcholine-Stimulatedtear Secretion In Rats, Zerri̇n Kapicioğlu, Gamze Çan, I. Nuri̇ Kalyoncu Jan 1999

Action Of Aspirin On Acetylcholine-Stimulatedtear Secretion In Rats, Zerri̇n Kapicioğlu, Gamze Çan, I. Nuri̇ Kalyoncu

Turkish Journal of Medical Sciences

In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received 60mg/kg of ASA and 30 min …

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Comparison Of Inhibitory And Bactericidalactivities Of Cefoperazone + Sulbactam Againstpseudomonas Aeruginosa Strains, From 1992 To1994, Pinar Zarakolu, Ni̇lay Çöplü, Ahmet Aslantürk, Belkis Levent, Engi̇n Güvener Jan 1999

Comparison Of Inhibitory And Bactericidalactivities Of Cefoperazone + Sulbactam Againstpseudomonas Aeruginosa Strains, From 1992 To1994, Pinar Zarakolu, Ni̇lay Çöplü, Ahmet Aslantürk, Belkis Levent, Engi̇n Güvener

Turkish Journal of Medical Sciences

In this study; inhibitory and bactericidal activities of cefoperazone + sulbactam against Pseudomonas aeruginosa strains were determined in two studies first in 1992 and second in 1994. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were determined by following the microdilution method recommended by NCCLS (Approved Standard M7-A2 1990) protocol. P.aeruginosa strains were isolated from different clinical materials. The results of the studies were then compared to point out if the difference between MIC and MBC values were significant and if there was resistance development following two years of use. In the first study in 1992: MIC90 and …

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Evaluation Of Ocular Surface Changes Usingimpression Cytology In Acne Vulgaris Patients, Banu N. Alp, Levent Karabaş, Ni̇lgün Bi̇len, Haluk Talu, Ahmet Kaur, Ateş Yanyali Jan 1999

Evaluation Of Ocular Surface Changes Usingimpression Cytology In Acne Vulgaris Patients, Banu N. Alp, Levent Karabaş, Ni̇lgün Bi̇len, Haluk Talu, Ahmet Kaur, Ateş Yanyali

Turkish Journal of Medical Sciences

Purpose: Acne vulgaris is a disease with no known ocular involvement and is most commonly seen in the younger population. The aim of this study was to examine the ocular surfaces of acne vulgaris patients with no ocular signs and symptoms by impression cytology. Methods: The study groups included 74 eyes of 37 acne vulgaris patients and 28 eyes of 14 healthy control subjects from the same age group. Schirmer I test, the tear break-up time test and the conjunctival impression cytology were performed in each patient. Results: We observed no difference between the tear break-up time and the Schirmer's …

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A Comparison Of The Effectiveness Of Sublinguallosartan, Sublingual Captopril And Sublingualnifedipine In Hypertensive Urgency, Yüksel Gökel, Sali̇m Satar, Sai̇me Paydaş Jan 1999

A Comparison Of The Effectiveness Of Sublinguallosartan, Sublingual Captopril And Sublingualnifedipine In Hypertensive Urgency, Yüksel Gökel, Sali̇m Satar, Sai̇me Paydaş

Turkish Journal of Medical Sciences

The use of sublingual captopril and nifedipine has been indicated in hypertensive emergencies and in patients with essential hypertension, with the assumption that by this route, there would be a faster absorption and thus a more rapid effect on blood pressure (BP) than by the oral route. A comparative study of the effects of Losartan, angiotensin II receptor antagonist, captopril and nifedipine on blood pressure was carried out in patients with hypertensive urgency. Sixty patients with hypertensive urgency were subdivided into 3 groups of 20 patients each. The first group received sublingual captopril (25 mg), the second group received sublingual …

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Total Parenteral Nutrition-Associated Cholestasisin Surgical Neonates, Alaeddi̇n Di̇lsi̇z Jan 1999

Total Parenteral Nutrition-Associated Cholestasisin Surgical Neonates, Alaeddi̇n Di̇lsi̇z

Turkish Journal of Medical Sciences

Purpose: The aim of this study was to determine the risk factors in the development of total parenteral nutrition associated cholestasis which is a significant clinical problem for pediatric surgeons. Methods: The medical records of 54 neonates who had received total parenteral nutrition for more than two weeks were reviewed retros pectively. Prematurity, duration of parenteral nutrition, enteral starvation, composition of the parenteral nutrition solution, the number of septic episodes and the presence of jejunostomy were evaluated as risk factors. The results were analyzed by dividing the patients into two groups, based on conjugated plasma bilirubin levels (greater or less …

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Lipid Peroxidation In Behçet's Disease In Activeand Remission Periods, Teoman Erdem, Necmetti̇n Akdeni̇z, İrfan Altuntaş, Fati̇h Akçay Jan 1999

Lipid Peroxidation In Behçet's Disease In Activeand Remission Periods, Teoman Erdem, Necmetti̇n Akdeni̇z, İrfan Altuntaş, Fati̇h Akçay

Turkish Journal of Medical Sciences

Recent few studies revealed that increased levels of oxygen free radicals might play a role in tissue damage. There are some studies in the literature proposing that increased levels of oxygen radicals might play a role in tissue damage, as also seen in Behçet's disease (BD). The aim of the present study was to measure plasma malondialde-hyde (MDA) (as an index of lipid peroxida-tion) levels in 23 patients with BD (13 men, 10 women with a mean age of 34.5 ± .2 years) both in active and in remission periods. Twenty-one healthy volunteers (11 men, 10 women) formed as the …

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Risk Assessment And Prenatal Diagnosis In Arecent Pregnancy In A Family With A Child Withdown Syndrome Due To T (21q;21q), Volkan Baltaci, Di̇dem Akyol, Sedat Kadanali Jan 1999

Risk Assessment And Prenatal Diagnosis In Arecent Pregnancy In A Family With A Child Withdown Syndrome Due To T (21q;21q), Volkan Baltaci, Di̇dem Akyol, Sedat Kadanali

Turkish Journal of Medical Sciences

No abstract provided.

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Flexion Contractures In A Diabetic Young Man(Rosenbloom Syndrome), Serpi̇l Savaş, Yavuz Bardak, Şevket Ercan Tunç, Meltem Çeti̇n, Selami̇i̇ Akkuş Jan 1999

Flexion Contractures In A Diabetic Young Man(Rosenbloom Syndrome), Serpi̇l Savaş, Yavuz Bardak, Şevket Ercan Tunç, Meltem Çeti̇n, Selami̇i̇ Akkuş

Turkish Journal of Medical Sciences

No abstract provided.

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Regional Odontodisplasia Presenting As A Softtissue Swelling, Murat Meti̇n, Cahi̇t Üçok, Ahmet Keski̇n, Fi̇gen Çi̇zmeci̇ Jan 1999

Regional Odontodisplasia Presenting As A Softtissue Swelling, Murat Meti̇n, Cahi̇t Üçok, Ahmet Keski̇n, Fi̇gen Çi̇zmeci̇

Turkish Journal of Medical Sciences

Regional odontodisplasia is a developmental anomaly of dental tissues with characteristic clinical, radiographic and histologic appearances. It most commonly affects the maxillary anterior teeth of both the primary and permanent dentition, and occurs in females twice as often as in males. The pathogenesis is unknown. A case of a twelve- year old female with regional odontodisplasia is presented. Although the affected teeth displayed the radiographical and clinical features of odontodisplasia, the patient appeared with significant soft tissue swelling on the anterior region of the mandible.

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Tooth Pain And Numb Chin As The Initialpresentation Of Systemic Malignancy, Sedat Çeti̇ner, Cansu Alpaslan, Nadi̇r Güngör, Ülker Koçak Jan 1999

Tooth Pain And Numb Chin As The Initialpresentation Of Systemic Malignancy, Sedat Çeti̇ner, Cansu Alpaslan, Nadi̇r Güngör, Ülker Koçak

Turkish Journal of Medical Sciences

No abstract provided.

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Comparative Genomic Hybridization (Cgh) Incancer Research, İbrahi̇m Keser Jan 1999

Comparative Genomic Hybridization (Cgh) Incancer Research, İbrahi̇m Keser

Turkish Journal of Medical Sciences

Cancer is a multifactorial and multistep process. Conventional cytogenetics has become a major working field in cancer research. Chromosome rearrangements are recognized as critical in the pathogenesis of human cancer. Molecular biology and molecular cytogenetics technology have increased our ability to identify genetic alterations in cancer cells. Polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), oligonucleotide-primed in situ DNA synthesis (PRINS) are the most common molecular cytogenetic procedures in cancer research but they have limits with precise localization in their principles in cancer researching. However, comparative genomic hybridization (CGH) is a powerful molecular cytogenetic technique which allows the analysis …

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Mao Inhibitors In Aging: Can They Serve As Protective Agents In Cardiac Tissue Against Oxidative Stress?, Ferhan Külahçioğlu Gi̇rgi̇n, Mert Özgönül, Güli̇nnaz Alper, Gülri̇z Menteş, Bi̇ltan Ersöz, Eser Yildirim Sözmen Jan 1999

Mao Inhibitors In Aging: Can They Serve As Protective Agents In Cardiac Tissue Against Oxidative Stress?, Ferhan Külahçioğlu Gi̇rgi̇n, Mert Özgönül, Güli̇nnaz Alper, Gülri̇z Menteş, Bi̇ltan Ersöz, Eser Yildirim Sözmen

Turkish Journal of Medical Sciences

Biological damage mediated by reactive oxygen species has been increasingly recognized in aging phenomena in recent decades. The increase in catecholamine metabolism is yet another physiological change in aging, predisposing the organism to supranormal hydrogen peroxide produc-tion as a by-product. This study was undertaken to investigate the alterations in oxidant- antioxidant status in rat cardiac tissue during aging. The effects of acute administration of monoamine oxidase (MAO) inhibitors on this status were also investigated to find possible preventive strategies in conjugate aging. MAO activities, malondialdehyde MDA and diene conjugate levels as well as superoxide dismutase and catalase activities were determined …

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Spontaneous Micronuclei In Cytokinesis-Blocked Bone Marrow And Peripheral Blood Iymphocytes Of Cml Patients, Di̇lek Koç Başer, Asuman Sunguroğlu, Işik Bökesoy, Akin Uysal Jan 1999

Spontaneous Micronuclei In Cytokinesis-Blocked Bone Marrow And Peripheral Blood Iymphocytes Of Cml Patients, Di̇lek Koç Başer, Asuman Sunguroğlu, Işik Bökesoy, Akin Uysal

Turkish Journal of Medical Sciences

Some genetic diseases may have increased cellular instability. Since chronic myloid leukemia (CML) has a genetic base, we aimed to seek the genetic instability of patients by micronucleus analysis, a mutation screening test which was applied by cytokinesis-blocked (CB) method. In this study, 10 CML patients at diagnosis, were analysed for their micronuclei (MN) frequencies. The values were evaluated in different culture conditions of blood and bone marrow cells. The results of CML patients are compared with control' MN values obtained by peripheral blood cultures induced with PHA. Between bone marrow and peripheral blood cultures MN values with or without …

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Quantitative Histopathology In Superficial Bladder Tumors: The Value Of Mean Nuclear Size In Progression And Recurrence, Gülsüm Özlem Elpek, Teki̇nalp Gelen, Gülten Karpuzoğlu, Osman Saka Jan 1999

Quantitative Histopathology In Superficial Bladder Tumors: The Value Of Mean Nuclear Size In Progression And Recurrence, Gülsüm Özlem Elpek, Teki̇nalp Gelen, Gülten Karpuzoğlu, Osman Saka

Turkish Journal of Medical Sciences

The aim of this study was to evaluate the quanititation of the nuclear size of tumor cells in superficial bladder carcinomas in progression and recurrence. Thirty-four cases diagnosed primarily as superficial bladder carcinoma grade II without muscle invasion (Stage pTa and pT1) between 1986-1993 at the Department of Pathology of Akdeniz University Faculty of Medicine were analysed in three groups: 1- Ten cases without recurrent tumor. 2- Twelve cases with primary and recurrent superficial bladder tumor. 3- Twelve cases with superficial primary tumor and recurrent tumor with muscle invasion. The mean nuclear diameter of the tumor cells were obtained by …

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