Digital Commons Network^™

Relation Of Total Homocysteine Level With Metabolic And Anthropometric Variables In Obese Children And Adolescents, Ayhan Abaci, Ahmet Zülfi̇kar Akelma, Osman Özdemi̇r, Şami̇l Hizli, Cem Hasan Razi, Kadi̇r Okhan Akin

Turkish Journal of Medical Sciences

To evaluate the total homocysteine (tHcy) level, a risk factor for atherosclerosis, atherothrombosis, and insulin resistance, for sex and pubertal state differences in obese children. Its relationship with metabolic and anthropometric parameters was also investigated. Materials and methods: The study involved obese children with a body mass index (BMI) above the 95th percentile who presented with the complaint of excessive weight gain, and healthy children with a BMI below the 85th percentile. Results: The study included 100 obese (mean age: 10.2 ± 2.7 years) and 71 healthy nonobese (mean age: 10.9 ± 2.6) children. A comparison of the data from …

The Evaluation Of The Results Of Adjuvant Chemoradiotherapy In Patients With Gastric Cancer: Results From A Single Center In Eastern Anatolia, Mehmet Bi̇li̇ci̇, Sali̇m Başol Teki̇n, Mustafa Kandaz, Keri̇m Çayir, Mustafa Vecdi̇ Erteki̇n, Hi̇lal Kiziltunç Özmen

Turkish Journal of Medical Sciences

To evaluate the results of postoperative chemoradiotherapy in patients with gastric cancer. Gastric cancer is an important public health problem in Turkey, especially in the eastern Anatolia region. Surgery is the primary modality for managing early-stage disease, but most patients who undergo a curative resection develop locoregional or distant recurrence. Therefore, the administration of adjuvant treatment in gastric cancer has great importance. Materials and methods: Operated patients with stage IB-IV (M0) gastric cancer were enrolled in this study. A total of 148 patients with gastric cancer who had completed adjuvant chemoradiotherapy were evaluated retrospectively. Total overall survival (OS), disease-free survival …

What Is The Best Cut-Off Point For Screening Gestational Diabetes In Turkish Women?, Aydin Köşüş, Nermi̇n Köşüş, Ni̇lgün Turhan

Turkish Journal of Medical Sciences

To find an optimal threshold level with higher sensitivity and specificity for screening of gestational diabetes mellitus (GDM) in Turkish pregnant women. Materials and methods: This was a retrospective study. Screening for GDM was performed in all pregnant women between 24 and 28 weeks of gestation using the 1 h 50 g glucose challenge test (GCT) with a subsequent 3 h 100 g oral glucose tolerance test (OGTT) for confirmation if screened positive. The glucose values obtained were analyzed by both the Carpenter and Coustan (C&C criteria) and National Diabetes Data Group (NDDG) criteria. Results: There were 808 women meeting …

Improvement Of Monosymptomatic Enuresis After Adenotonsillectomy In Children With Obstructive Sleep Apnea Syndrome, Ahmet Gökçe, Sündüs Aslan, Fati̇h Rüştü Yalçinkaya, Mürsel Davarci, Yusuf Seli̇m Kaya, Nazan Savaş, Sadik Görür, Şafak Dağli, Ahmet Namik Ki̇per, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

To investigate the prevalence of monosymptomatic enuresis (ME) in children diagnosed with obstructive sleep apnea syndrome (OSAS) and the rate of resolution or improvement in enuresis following adenotonsillectomy. Materials and methods: We retrospectively reviewed the charts of 541 consecutive patients who underwent adenotonsillectomy for OSAS secondary to adenotonsillar hypertrophy between January 2005 and January 2009. All of the charts for patients between 5 and 18 years of age at the time of surgery (n = 398) were included in the study. After reviewing the charts, the families were contacted by telephone. Those patients who had shown preoperative symptoms of enuresis …

Adhesion Molecule Interactions Influence The Implementation Of Immune Responses To Infection, Maureen Ann Cox

All ETDs from UAB

Interactions mediated by intercellular adhesion molecule-1 (ICAM-1) enhance both the antigenic and cytokine signals that CD8 T cells perceive, and these interactions have been suggested to be required for the formation of memory CD8 T cells. Following acute lymphocytic choriomeningitis virus (LCMV) infection of ICAM-1-/- mice, we observe elevated numbers of "effector-phenotype" (CD127lo KLRG-1hi IL-2-) virus-specific CD8 T cells well into the memory phase, while the development of memory-phenotype CD8 T cells (CD127hi KLRG-1lo IL-2 producing) is not impaired. The enhanced maintenance of effector-phenotype cells is due to ICAM-1 deficiency on non-T cell subsets, suggesting a role for ICAM-1 mediated …

Modulation Of Autoimmune Diabetes By B Cells Specific For N-Acetyl-D-Glucosamine, Brian L. Dizon

All ETDs from UAB

Type I diabetes (T1D) is an autoimmune disease in which ß cells are destroyed by the immune system; however, role of infections in type I diabetes (T1D) pathogenesis is unclear. Reports suggesting that childhood Group A Streptococcal (GAS) infections protected against T1D prompted us to study how antibodies to N-acetyl-D-glucosamine (GlcNAc), which are induced by GAS infection, influenced T1D development. We found that GlcNAc-specific antibodies reacted with ß cell secretory granules, and neonatal NOD mice immunized with GAS or given GAS-immune sera were protected from spontaneous diabetes. Monoclonal GlcNAc-specific IgM blocked activation and effector responses to islet antigens by diabetogenic …

Proteomic Clues To The Pathogenesis Of Alexander Disease, Daniel L. Flint

All ETDs from UAB

Since the initial report identifying mutations in GFAP as the primary genetic defect in the astrogliopathy Alexander Disease (AxD) much progress has been made in elucidating the molecular details underpinning the pathogenic role of mutant GFAP in astrocytes. In particular, data collected from mouse, fly, and cell culture models of AxD have isolated several prominent cellular changes that are associated with mutant GFAP expression including oxidative stress, proteasome inhibition, reduced expression of the astrocyte glutamate transporter GLT-1, and loss of neurons; these models have also successfully recapitulated the pathological hallmark of AxD--protein aggregates known as Rosenthal fibers (RFs). To date, …

Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix

All ETDs from UAB

The facultative pathogen Streptococcus pneumoniae is capable of producing a polysaccharide (PS) capsule that prevents bacterial recognition and clearance by the host immune system. Over 90 antigenically distinct capsule serotypes have been identified. Because anti-capsule antibodies can mediate bacterial clearance, capsule diversity is critical to S. pneumoniae survival. However, the mechanisms of capsule evolution remain unclear. Due to the complex interaction of capsule synthesis (cps) genes, it is commonly thought that pneumococcal serotypes evolve once and that all clinically relevant serotypes are genetically derived from a single founding clone. In this dissertation we demonstrate a novel mechanism of capsule evolution …

Seg1 Controls Eisosome Assembly And Shape, Karen E. Moreira, Sebastian Schuck, Bianca Schrul, Florian Fröhlich, James B. Moseley

Dartmouth Scholarship

Eisosomes are stable domains at the plasma membrane of the budding yeast Saccharomyces cerevisiae and have been proposed to function in endocytosis. Eisosomes are composed of two main cytoplasmic proteins, Pil1 and Lsp1, that form a scaffold around furrow-like plasma membrane invaginations. We show here that the poorly characterized eisosome protein Seg1/Ymr086w is important for eisosome biogenesis and architecture. Seg1 was required for efficient incorporation of Pil1 into eisosomes and the generation of normal plasma membrane furrows. Seg1 preceded Pil1 during eisosome formation and established a platform for the assembly of other eisosome components. This platform was further shaped and …

Contribution Of The Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (Erpc) To Complement Resistance Of Borrelia Burgdorferi, Claudia Hammerschmidt, Teresia Hallström, Christine Skerka, Reinhard Wallich, Brian Stevenson, Peter F Zipfel, Peter Kraiczy

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs). Here, we extend our analyses to the contribution of CRASP-4 in mediating complement resistance of B. burgdorferi and its interaction with human complement regulators. CRASP-4 (also known as ErpC) was immobilized onto magnetic beads and used to capture proteins from human serum. Following Western blotting, factor H (CFH), CFH-related protein 1 (CFHR1), CFHR2, and CFHR5 were identified as ligands of CRASP-4. To analyze the impact of native CRASP-4 on mediating survival of serum-sensitive cells in human serum, a B. garinii strain was generated …

Determination Of The Molecular Mechanisms Of Hyperglycemia-Induced Changes In Cav3.2 Calcium Channel Properties, Ginny Marie Keeling

Master's Theses

Hyperglycemia can cause altered excitability due to increased CaV3.2 T-type calcium channel function, bestowing diabetics an increased neuropathy risk. The objective of this study was to understand the molecular mechanisms of increased CaV3.2 function during hyperglycemia in vitro, which leads to a 58% increase in current density and increased channel open probability (PO), among other changes. Two major findings are reported in this study:

1) The enzymatic elimination of extracellular N-acetylneuraminic acid (NANA) moieties reversed the increase in current density and the shift in PO, showing that hyper-glycosylation alters channel function in disease.

2) Treatment with GM1 (a ganglioside highly …

Quantitative Reagent-Free Detection Of Fibrinogen Levels In Human Blood Plasma Using Raman Spectroscopy, Kelvin Poon, Fiona Lyng, Peter Knief, Orla L. Howe, Aidan Meade, James Curtin, Hugh Byrne, Joseph Vaughan

Articles

Fibrinogen assays are commonly used as part of clinical screening tests to investigate haemorrhagic states, for detection of disseminated intravascular coagulation and as a predictor of a variety of cardiovascular events. The Clauss assay, which measures thrombin clotting time, is the most commonly used method for measuring fibrinogen levels. Nevertheless, inconsistencies are present in inter-manufacturer reagent sources, calibration standards and methodologies. Automated coagulation analysers, which measure changes in optical density during the prothrombin time (PT-Fg), have found use in many hospitals. However, the PT-Fg method is found to give falsely elevated values due to varying choices of calibrants, reagents and …

A Novel Function For Snap29 (Synaptosomal-Associated Protein Of 29 Kda) In Mast Cell Phagocytosis., Jordan Wesolowski, Vernon Caldwell, Fabienne Paumet

Department of Microbiology and Immunology Faculty Papers

Mast cells play a critical role in the innate immune response to bacterial infection. They internalize and kill a variety of bacteria and process antigen for presentation to T cells via MHC molecules. Although mast cell phagocytosis appears to play a significant role during bacterial infection, little is known about the proteins involved in its regulation. In this study, we demonstrate that the SNARE protein SNAP29 is involved in mast cell phagocytosis. SNAP29 is localized in the endocytic pathway and is transiently recruited to Escherichia coli (E. coli)-containing phagosomes. Interestingly, overexpression of SNAP29 significantly increases the internalization and killing of …

Neuroangiogenesis: A Vascular Basis For Alzheimer's Disease And Cognitive Decline During Aging, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Angiogenesis directs development of the brain's microcirculation during antenatal and postnatal development, but its role later in life is less well recognized. I contend that during senescence a reduced cerebral capillary density accounts in part for the vascular cognitive impairment observed in many older persons and possibly for some forms of Alzheimer's disease. I propose that neuroangiogenesis is essential throughout adult life for maintaining the microcirculation of the cerebral cortex and elsewhere in the brain and that it commonly declines with old age. To support this hypothesis I have examined the neurological literature for relevant studies on cerebral capillary density …

Mnsod And Autophagy In Prevention Of Oxidative Mitochondrial Injuries Induced By Uvb In Murine Skin, Vasudevan Bakthavatchalu

Theses and Dissertations--Toxicology and Cancer Biology

UVB radiation is a known environmental carcinogen that causes DNA damage and increase ROS generation in mitochondria. Accumulating evidence suggests that mtDNA damage and increased ROS generation trigger mitochondrial translocation of p53. Within mitochondria, p53 interacts with nucleoid macromolecular complexes such as mitochondrial antioxidant MnSOD, mitochondrial DNA polymerase Polγ, and mtDNA. Mitochondria are considered to be a potential source for damage-associated molecular patterns (DAMPs) such as mtDNA, cytochrome C, ATP, and formyl peptides. Intracytoplasmic release of DAMPs can trigger inflammasome formation and programmed cell death processes. Autophagic clearance of mitochondria with compromised integrity can inhibit inflammatory and cell death processes. …

Cutaneous Anthrax Patients In Eastern Anatolia, Turkey: A Review Of 44 Adults Cases, Kemaletti̇n Özden, Zülal Özkurt, Serpi̇l Erol, Muhammet Hami̇dullah Uyanik, Mehmet Parlak

Turkish Journal of Medical Sciences

Anthrax is a zoonotic infectious disease caused by B. anthracis. It remains as an important issue in developing countries and it is a potential threat for the world because of its use as a biological weapon. In this study, we evaluated the epidemiological, clinical, and laboratory characteristics of 44 patients with cutaneous anthrax in our region. Materials and methods: The study included 44 cutaneous anthrax patients admitted to our hospital from the Eastern Anatolia Region of Turkey between 2005 and 2008. Results: Out of 44 cases, 24 (54.5%) were male and 20 (45.5%) female. The mean age was 41 ± …

Skin Prick Test Results And Prevalence Of Allergic Symptoms In Workers Exposed To Toluene, İsmai̇l Karabulut, Tevfi̇k Pinar, Hayri̇ye Karabulut, Meli̇ke Demi̇r, Güli̇stan Karadeni̇z, Riza Murat Karaşen

Turkish Journal of Medical Sciences

To determine the distribution of allergens and allergic symptoms according to occupation groups in those who were exposed to toluene and presented with allergic rhinitis symptoms. Materials and methods: Of the 2005 patients who were administered an allergy test with the prediagnosis of allergic rhinitis, the files of 138 patients who were exposed to toluene were analyzed retrospectively. Results: The mean age of the patients was 35 ± 10 years. Distributions of symptoms and allergens of 57 patients (41.3%) with negative skin prick test and 81 patients (58.7%) with positive skin prick test were analyzed according to occupation groups. There …

Infant Mortality In Northeastern Anatolia And Associated Factors, Serhat Vançeli̇k, Memet Işik, Ahmet Ruhi̇ Toraman, Zekeri̇ya Aktürk

Turkish Journal of Medical Sciences

To explore the causes of infant mortality. Infant mortality is the most important criterion for the evaluation of the sufficiency of mother and child health care and the planning of health care provision. In this study, we investigated infant mortality and associated factors in 7 provinces located in northeastern Turkey. The main outcome of this study was reasons for neonatal mortality. Materials and methods: We created a cross-sectional study and included all babies born in the year 2009 who died during the first 365 days of life. Data were collected from the primary care providers. A data collection form was …

The Effect Of Soya Bean Meal On Tibial Articular Cartilage Growth In Mice After Suckling Period: A Histomorphometric And Biochemical Study, Simin Fazelipour, Seyed Babak Kiaei, Amir Hossein Eghtesad, Zahra Tootian

Turkish Journal of Medical Sciences

To examine the effects of an oral supplement of soya bean meal on the histomorphometric alteration of tibia cartilage and the serum levels of calcium and alkaline phosphatase in 3-week-old female mice using a computer-assisted histomorphometric method. Materials and methods: Forty immature BALB/c female mice were selected and divided into 4 groups. They were fed for 3 months with 4 different regimens: a low-protein regimen without soya bean meal, 23% protein without soya bean meal, 20% of the total protein being provided by soya bean meal, and 40% of the total protein being provided by soya bean meal. After 3 …

A Comparative Investigation Of Anti-Müllerian Hormone (Amh) And Various Biochemical Parameters In Patients With Cryptorchidism, Oligospermia, Or Varicocele*, Turan Akdağ, Ali̇ Muhtar Ti̇fti̇k, Levent Sariyildiz

Turkish Journal of Medical Sciences

To investigate the serum AMH and various biochemical parameter levels in patients with cryptorchidism, oligospermia, or varicocele. Materials and methods: This study included 100 participants, divided into 5 groups: cryptorchidism (n = 20), varicocele (n = 20), oligospermia (n = 20), and 2 control groups [control 1, 8-12 years old (n = 20) and control 2, 18-24 years old (n= 20)]. Using the blood samples drawn from both patient and control groups, AMH, testosterone, FSH, LH, and prolactin parameters were investigated. Results: AMH values measured were found to be 73.04 ± 44.5 ng/mL and 84.81 ± 59.1 ng/mL in 20 …

The Effects Of Axillary Block Using The Multiple Injection Method With Ropivacaine In Uremic And Nonuremic Patients*, Hülya Çevi̇k, Ahmet Mahli̇, Demet Coşkun

Turkish Journal of Medical Sciences

To compare the sensory and motor block quality in axillary brachial plexus block using the multiple injection method with ropivacaine in uremic and nonuremic patients. Materials and methods: Examined were 60 patients scheduled for orthopedic surgery of the distal upper extremity (nonuremic group: group N, n = 30) or creation of an arteriovenous fistula (uremic group: group U, n = 30) with an axillary brachial plexus block. The median, radial, ulnar, and musculocutaneous nerves were selectively localized by nerve stimulation. After obtaining an appropriate peripheral motor response, predetermined volumes of ropivacaine (0.5%), in accordance with a formula, were selectively injected …

Plasma Lipid Levels In Patients With Acute Bacterial Infections, Mohammad Nassaji, Raheb Ghorbani

Turkish Journal of Medical Sciences

To assess the impact of acute bacterial infections on plasma lipid levels and to determine the value of plasma lipid measurements in the diagnosis of acute bacterial infection. Materials and methods: A cross-sectional study was conducted involving 112 patients with acute bacterial infections admitted in hospital and 112 healthy individuals as controls. Levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein, and triglycerides were measured in blood samples of all subjects. Mean levels of serum lipids were compared in both groups. Results: Both groups were matched based on age (P = 0.10), sex (P = 0.789), BMI (P = 0.515), …

Comments On: In Vitro Efficacy Of Hyperbaric Oxygen Therapy Against Leishmania Tropica Promastigotes And Amastigotes, Yalçin Önem, Vedat Turhan

Turkish Journal of Medical Sciences

No abstract provided.

Dietary Boron Intake Does Not Change The Ischemic Tolerance And Preconditioning Response In Isoproterenol-Induced Myocardial Injury In Healthy Rats, Mehmet Fati̇h Karakaş, Mustafa Kurt, Uğur Arslantaş, Göktürk İpek, Esra Karakaş, Emi̇ne Bi̇len, Hüsametti̇n Erdamar

Turkish Journal of Medical Sciences

Boron is important for many enzymes, most of which also have a role in the ischemic tolerance of the myocardium. We aimed to evaluate the influence of dietary boron intake on ischemic tolerance in a rat model. Materials and methods: Rats were divided into 3 groups according to the ischemia protocol: Sham (S) (n = 20 total), ischemia only (Isc-only) (n = 40 total), and remote ischemic preconditioning + ischemia (RIPC+Isc) (n = 40 total) groups. These 3 groups were further divided into 4 according to the amount of daily dietary boron (

Effects Of Lycopene On Plasma Glucose, Insulin Levels, Oxidative Stress, And Body Weights Of Streptozotocin-Induced Diabetic Rats, Muhsi̇n Aydin, Sefa Çeli̇k

Turkish Journal of Medical Sciences

To determine possible therapeutic effects of oral lycopene supplementation on plasma insulin levels, lipid peroxidation, blood glucose levels, and the antioxidant defense system of streptozotocin-induced diabetic rats. Materials and methods: Classical biochemical methods were used to determine plasma malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Enzyme-linked immunosorbent assay was used to determine plasma insulin levels and reverse transcriptase-polymerase chain reaction was used to determine the levels of brain antioxidant enzymes (SOD, CAT, and GSH-Px). Results: It was found that the diabetes-related increase in blood glucose levels was reduced by supplementation …

Effect Of Ovulation Induction On Qt Dispersion In Electrocardiography, Ayla Üçkuyu, Fai̇ka Ceylan Çi̇ftçi̇, Özgür Çi̇ftçi̇, Emel Ebru Özçi̇men, Erzat Toprak, Erdem Turhan

Turkish Journal of Medical Sciences

To investigate whether ovulation induction resulting in supra-physiological concentration range of ovarian hormones has an effect on interlead ventricular depolarization heterogeneity via QT dispersion measurements. Estrogens influence the duration of cardiac repolarization but there is no significant change in the QT interval duration within the range of physiological estradiol variations. Materials and methods: Included in the study were 40 subjects, in whom ovulation induction was planned, and 20 volunteers. During the study, a 12-lead electrocardiogram of each woman was carried out 3 times: for the first time on day 2-3 of the menstrual cycle (menstrual day), for the second time …

Electrical Fatalities In Ankara Over 11 Years, Ramazan Akçan, Emre Karacaoğlu, Alper Keten, Aysun Balseven Odabaşi, Çi̇ğdem Kanburoğlu, Ali̇ Riza Tümer, Hani̇fe Alkurt-Alkan

Turkish Journal of Medical Sciences

Electrical injuries are still responsible for significant morbidity and mortality; however, they are generally preventable with simple safety measures. This study Abstracts to determine the general features of electrical fatalities, and to draw attention of health professionals towards such preventable deaths. Materials and methods: A retrospective evaluation of records of electrocution-related deaths in Ankara, Turkey, was conducted over 11 years (1998-2008). Results: Out of 12,263 autopsy cases, 100 (0.8%) were secondary to electrocution. Most of the victims were male (n = 94; 94%) while only 6 were female. Victims’ age ranged from 1 year to 76 years, with a mean …

Effects Of Neoadjuvant Chemotherapy On Pathological Parameters And Survival In Patients Undergoing Radical Cystectomy For Muscle-Invasive Bladder Cancer, Alper Çağlayan, Zi̇ya Akbulut, Ali̇ Fuat Atmaca, Serkan Altinova, Meti̇n Kiliç, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

Aim: To evaluate the effect of neoadjuvant chemotherapy on tumor pathology and patient survival in patients with muscle-invasive bladder cancer undergoing radical cystectomy. Neoadjuvant chemotherapy is believed to prevent micrometastasis and provide pathological downstaging. Materials and methods: Between June 2004 and March 2009, 74 patients with muscle-invasive bladder cancer were treated with radical cystectomy. Patients fit to receive chemotherapy were administered systemic chemotherapy of methotrexate, vinblastine, Adriamycin, and cisplatin (MVAC); gemcitabine and cisplatin (GC); or carboplatin and gemcitabine (CG). Patients in Group 1 (n = 36) did not receive any chemotherapy, while the remaining 38 patients in Group 2 did …

Biochemical And Structural Changes Of The Kidney In Mice Exposed To Phenol, Zahra Tootian, Ali Louei Monfared, Simin Fazelipour, Mohammad Taghi Shybani, Fatemeh Rouhollah, Farhang Sasani, Ebrahim Molaemi

Turkish Journal of Medical Sciences

Aim: To investigate the histology and function of the kidney in mice exposed to different concentrations of phenol through the gavage method for 10 consecutive days. Materials and methods: Forty female BALB/c mice were selected and randomly divided into 1 control group and 3 experimental groups. The control group was administered distilled water through the gavage method, while the experimental groups received daily doses of 80, 180, and 320 mg/kg of phenol, respectively. After 10 days, blood samples were collected and the sera were analyzed biochemically. Renal tissue samples were also taken and histopathological changes of the kidneys were examined …

Effect Of Prenatal Exposure To Cigarette Smoke On The Conduction Of Sensory Nerve Fibers In The Rat, Jumah Shakhanbeh

Turkish Journal of Medical Sciences

Aim: To investigate the effect of prenatal exposure to cigarette smoke (CS) on the conduction of sensory nerve fibers in the adult rat offspring. Materials and methods: Pregnant rats were exposed to CS by inhalation during the gestation period. The saphenous nerve in the adult offspring was exposed in vivo, and the conduction parameters of the threshold, maximum strength of stimulation, conduction velocity, and amplitude of compound action potentials (CAPs) of A\alpha\beta-, A\delta-, and C-fibers were examined. Results: Prenatal exposure to CS induced significant reduction (P < 0.005) in the peak amplitude of CAPs of A\alpha\beta- and A\delta-fibers. The conduction velocity of A\alpha\beta-fibers and C-fibers was significantly (P < 0.025-0.05) increased after prenatal exposure to CS. Conclusion: Prenatal exposure to CS attenuates the conduction of sensory nerve fibers in the rat saphenous nerve.