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Language Of Music And Its Psychophysical Foundations, Marina Korsakova-Kreyn

Lander College for Women - The Anna Ruth and Mark Hasten School Publications and Research

Application of music in rehabilitation medicine requires an understanding of the mechanisms of music perception. This article discusses differences in character of the basic melodic elements and addresses some of the specifics of tonal space. Colloquially, music is called the language of emotion. Bearing in mind that high-level cognitive functioning in humans is inseparable from affective consciousness, investigating the mechanisms of emotional processing belongs to an important area of cognitive sciences. Studying music perception can help to advance methods of music therapy and to elucidate major aspects of human consciousness.

The Role Of Activin A Signaling In Gastric Reflux-Related Diseases And The Progression To Esophageal Adenocarcinoma, Cedric J. Roudebush

Honors Undergraduate Theses

Gastroesophageal reflux disease (GERD), or acid reflux, affects 6-9 million people in the United States. It is characterized by a reflux of gastric acid and bile salts from the stomach into the esophagus, causing injuries to the esophagus known as Barrett's esophagus (BE). BE is the main risk factor for the development of esophageal adenocarcinoma (EAC), a devastating cancer in the esophagus whose molecular roots remain poorly understood. In recent years, evidence points to the esophageal epithelium itself as responsible for causing and promoting inflammation upon injury by gastric reflux, namely via an increase in inflammatory cytokine secretion. This project …

Impact Of Work-Life Balance On Health-Related Quality Of Life Among College Students, Emily Vernet

Honors Undergraduate Theses

Work-life balance involves the management of work and social responsibilities. Specifically, it describes the ability to meet the demands of multiple roles involving academics, social, personal, and professional life. Literature has shown that there is an increasing number of students who are working while taking classes at a university. Previous research has described how young adults balance working and going to school and how work hours influence student's mental, physical, and health behaviors. The purpose of this study is to examine the association between a student's ability to balance work demands, student and life responsibilities, and health outcomes. Using a …

Unraveling Pdi And Its Interaction With Ab Toxins, Jessica Guyette

Electronic Theses and Dissertations

Protein disulfide isomerase (PDI) is an essential endoplasmic reticulum (ER) protein that acts as both an oxidoreductase and chaperone. It exhibits substantial flexibility and undergoes cycles of unfolding and refolding in its interaction with cholera toxin (Ctx), which is a unique property of PDI. This unfolding allows PDI to disassemble the Ctx holotoxin, which is required for Ctx activity. Here, we investigated the unfolding and refolding property of PDI and how this affects its interaction with bacterial toxins. PDI showed remarkable redox-linked conformational resilience that allows it to refold after being thermally stressed. Deletion constructs of PDI showed that both …

Total Salivary Protein Concentration And Its Correlation To Dental Caries, Emyli Peralta

Honors Undergraduate Theses

Introduction: According to the World Health Organization, dental cavities are the number one chronic disease in children. Saliva coats the teeth all day and can serve many functions to maintain and protect teeth. Saliva has many proteins that can be both detrimental and essential to the preservation of tooth enamel. The purpose of this study is to determine if a correlation exists between the total protein concentration in saliva and the prevalence of cavities in the mouth. We hypothesized that there would be a positive correlation with total salivary protein concentration and the prevalence of cavities in the participant. Methods: …

Overview Of Direct Thrombin Inhibitors For Use In Staphylococcus Aereus Infections, Joseph C. Risler

Honors Undergraduate Theses

The pathogenicity and intractable nature of the microorganism Staphylococcus aureus (SA) has been long documented and highlighted by many health care agencies, with emphasis on its ability to exploit the human coagulation system to deadly effect. Two drugs from a class of inhibitors known as Direct Thrombin Inhibitors (DTI) have been shown to have a substantial effect on the enzyme secreted by SA known as Staphylocoagulase (SC), but up until now the application of this potential treatment has been limited. This paper strives to supply an overview of these clinical studies and propose a novel protocol for testing DTI's on …

Thermal Block Of Action Potentials Is Primarily Due To Voltage-Dependent Potassium Currents: A Modeling Study, Michael W. Jenkins, Hillel J. Chiel

Faculty Scholarship

Objective. Thermal block of action potential conduction using infrared lasers is a new modality for manipulating neural activity. It could be used for analysis of the nervous system and for therapeutic applications. We sought to understand the mechanisms of thermal block. Approach. To analyze the mechanisms of thermal block, we studied both the original Hodgkin/Huxley model, and a version modified to more accurately match experimental data on thermal responses in the squid giant axon. Main results. Both the original and modified models suggested that thermal block, especially at higher temperatures, is primarily due to a depolarization-activated hyperpolarization as increased temperature …

Soft-Surface Grasping: Radular Opening In Aplysia Californica, Catherine E. Kehl, Joey Wu, Sisi Lu, Richard F. Drushel, Rebekah K. Smoldt, Hillel J. Chiel

Faculty Scholarship

Grasping soft, irregular material is challenging both for animals and robots. The feeding systems of many animals have adapted to this challenge. In particular, the feeding system of the marine mollusk Aplysia californica, a generalist herbivore, allows it to grasp and ingest seaweeds of varying shape, texture and toughness. On the surface of the grasper of A. californica is a structure known as the radula, a thin flexible cartilaginous sheet with fine teeth. Previous in vitro studies suggested that intrinsic muscles, I7, are responsible for opening the radula. Lesioning I7 in vivo does not prevent animals from grasping and ingesting …

Audiometric Threshold Shifts After Total Knee Arthroplasty By Using Gentamicin-Loaded Bone Cement, Adem Çöbden, İsmet Yalkin Çamurcu, Serap Bulut Çöbden, Hakan Sofu, Hani̇fi̇ Üçpunar, Ahmet Sevencan, Hüseyi̇n Demi̇rel

Turkish Journal of Medical Sciences

Background/aim:The aim of this study was to investigate postoperative audiometric threshold shifts in patients who underwent primary total knee arthroplasty (TKA) using gentamicin-loaded bone cement (GLBC) in comparison with the ones who underwent TKA without GLBC.Materials and methods: Forty patients (gentamicin group) who underwent primary TKA usingGLBC and 29 patients (control group) who underwent primary TKA using standard bone cement were included in this prospective case-control study. Baseline pure-tone audiometric evaluation was performed preoperatively and repeated at the postoperative third day for all patients. Control audiometric evaluation was performed weekly for patients who were diagnosed with ototoxicity according to audiometric …

Murine Mpdz-Linked Hydrocephalus Is Caused By Hyperpermeability Of The Choroid Plexus., Junning Yang, Claire Simonneau, Robert Kilker, Laura Oakley, Matthew D. Byrne, Zuzana Nichtova, Ioana Stefanescu, Fnu Pardeep-Kumar, Sushil Tripathi, Eric Londin, Pascale Saugier-Veber, Belinda Willard, Mathew Thakur, Stephen Pickup, Hiroshi Ishikawa, Horst Schroten, Richard Smeyne, Arie Horowitz

Cardeza Foundation for Hematologic Research

Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality. We show by magnetic resonance imaging that contrast medium penetrates into the brain ventricles of mice carrying a Mpdz loss-of-function mutation, whereas none is detected in the ventricles of normal mice, implying that the permeability of the choroid plexus epithelial cell monolayer is abnormally high. Comparative proteomic analysis of the cerebrospinal fluid of normal and hydrocephalic mice revealed up to a 53-fold increase …

Relationship Between Plasma Ykl-40 Levels And Endothelial Dysfunction In Chronic Kidney Disease, Gül Sema Yildiran Keski̇n, Özant Helvaci, Çağri Yayla, Özge Tuğçe Paşaoğlu, Çağlar Keski̇n, Seli̇m Turgay Arinsoy, Ülver Deri̇ci̇

Turkish Journal of Medical Sciences

We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). …

Validity And Reliability Of The Amsterdam Preoperative Anxiety And Information Scale In The Turkish Population, Funda Çeti̇nkaya, Esi̇n Kavuran, Kevser Sevgi̇ Ünal Aslan

Turkish Journal of Medical Sciences

This study aimed to adapt the Amsterdam Preoperative Anxiety and Information Scale (APAIS) to measure the preoperative anxiety of adult Turkish patients undergoing surgery.Materials and methods: The sample of this methodological study included 210 patients. Data were collected by using personal information forms, the APAIS, and the State Anxiety Scale (STAI). Cronbach's ∝-coefficient was calculated, and test-retest reliability was tested. Results: Cronbach's ∝-coefficients of the APAIS anxiety and information requirement subscales were 0.897 and 0.786, respectively. The mean test and retest scores of the APAIS were not different. The test and retest scores of the patients were significantly, positively, and …

Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Hantavirus and Borrelia burgdorferi are two zoonotic agents that pose a great risk especially for people living in forest areas. This study aimed to investigate the seroprevalence of hantavirus and B. burgdorferi in forest villages of Düzce and its relationship with sociodemographic features.Materials and methods: The presence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against hantavirus and B. burgdorferi in serum samples was investigated via enzyme-linked immunosorbent assay (ELISA). Hantavirus IgG and B. burgdorferiIgM and IgG positivity was then validated by western blot (WB) method. Results: During the analyses,193 serum samples were tested. Eleven (6%) cases of …

Prevalence Of Atopy And Allergic Rhinitis In Patients With Adult Non-Cystic Fibrosis Bronchiectasis, Eli̇f Yelda Ni̇ksarlioğlu, Saci̇de Rana Işik, Mehmet Ati̇lla Uysal, Derya Ünal, Güngör Çamsari

Turkish Journal of Medical Sciences

Background/aim: Non-cystic fibrosis bronchiectasis (non-CF BR) is common in developing countries.Limited data are available regarding the impact of atopy, and no data are available regarding allergic rhinitis in patients with adult bronchiectasis.The aim of this study was to evaluate the prevalence of atopy and allergic rhinitis in the clinical conditions of patients with BR.Materials and methods: The study enrolled 101 patients who were diagnosed with non-CF BR using high-resolution computed chest tomography. Allergic rhinitis (AR) was defined by skin prick test (SPT) positivity and the presence of any nasal symptoms (watery runny nose, nasal obstruction, nasal itching, and sneezing). Results: …

Reliability, Validity, And Cross-Cultural Adaptation Study Of The Turkish Version Of The Patient-Rated Wrist/Hand Evaluation Questionnaire, Deni̇z Öke Topcu, Sevği̇ İkbali̇ Afşar

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to cross-culturally adapt the Turkish version of the Patient-Rated Wrist/Hand Evaluation (T-PRWHE) questionnaire for use in the Turkish patient population. Moreover, we aimed to evaluate the reliability and validity of the T-PRWHE questionnaire. Materials and methods: A total of 166 patients with hand and wrist problems were included in the study. They completed the T-PRWHE, the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, and the 36-Item Short-Form Health Survey (SF-36) at baseline and at the 3rd month of the study. Reliability was evaluated by analyzing internal consistency (Cronbach alpha coefficient) and …

Validity And Reliability Of The Turkish Version Of The Modified Yale Preoperative Anxiety Scale, Zehra Hati̇poğlu, Oğuzhan Kirdök, Di̇lek Özcengi̇z

Turkish Journal of Medical Sciences

Background/aim: The modifiedYa l ePreoperative Anxiety Scale (m-YPAS) is widely used to measure children's anxiety levels. The aim of this study was to translate the m-YPAS into Turkish and test its validity and reliability in Turkish children.Materials and methods: The English version of the m-YPAS was translated into Turkish using the forward-back-forward translation technique. This study enrolled 120 children. The m-YPAS was administered to 120 children who were recorded on video. The State-Trait Anxiety Inventory for Children (STAIC) was used for only 30 of 120 children. The videotapes were evaluated by two experienced observers [an anesthesiologist, ObA(an), and a psychologist, …

Neonatal Outcomes In Syrian And Other Refugees Treated In A Tertiary Hospital In Turkey, İstemi̇ Han Çeli̇k, Zehra Arslan, Di̇lek Ulubaş Işik, Ömer Lütfi̇ Tapisiz, Leyla Mollamahmutoğlu, Ahmet Yağmur Baş, Ni̇hal Demi̇rel

Turkish Journal of Medical Sciences

Background/aim: Turkey accepts refugees from many countries, principally Syria. More than 2.7 million refugees live in Turkey.We evaluated the neonatal outcomes of refugees. Materials and methods: We retrospectively reviewed the clinical and demographic characteristics of refugee infants born in our hospital between August 2013 and September 2016. Results: Refugees (718 Syrian, 136 Iraqi, 32 Afghani, and 21 of other nationalities) accounted for 907 of 49,413 births. The mean refugee maternal age was lower than that of Turkish women, whereas the gestational age (GA) and birthweight were similar. Refugees required fewer cesarean sections but exhibited greater small- and large-for-GA rates (P < 0.05). Refugee and Turkish infant mortality rates did not differ significantly (0.8 vs. 0.4%). Eighty-nine (12.3%) refugee neonates and 6682 (13.5%) Turkish neonates were admitted to our neonatal intensive care unit (NICU). Jaundice and perinatal asphyxia were significantly more common in refugees, whereas respiratory distress syndrome, GA ≤32 weeks, and infant birthweight

Reference Values And Prediction Equation For The 6-Minute Walk Test In Healthy Children Aged 6?12 Years Old, Buse Özcan Kahraman, Ertuğrul Yüksel, Abdurrahman Nalbant, Umut Zi̇ya Koçak, Bayram Ünver

Turkish Journal of Medical Sciences

Background/aim: The 6-minute walk test (6MWT) is the most commonly used and well-established test to measure functional exercise capacity in research and clinical settings. Country-specific reference values are important to interpret the results of 6MWT. However, no reference values have been reported for healthy Turkish children aged between 6 and 12 years old. The aim of this study was to determine normal reference values for the 6MWT test of healthy Turkish children aged between 6 and 12 years old. Materials and methods: Two hundred and sixty-two healthy children aged between 6 and 12 years old were included in this cross-sectional …

The Effects Of Cervical Kinesiotaping On Neck Pain, Range Of Motion, And Disability In Patients Following Thyroidectomy: A Randomized, Double-Blind, Sham-Controlled Clinical Trial, Aysun Genç, Süleyman Utku Çeli̇k, Volkan Genç, Derya Öztuna, Bi̇rkan Sonel Tur

Turkish Journal of Medical Sciences

Background/aim: This was a randomized, double-blind, sham-controlled study.Thyroidectomy is a frequently performed surgical procedure and head and neck extension during this operation facilitates surgery. Patients may experience postoperative neck pain and cervical range of motion (ROM) limitation due to the surgical position following thyroidectomy. It was aimed herein to investigate the short-term effects of kinesiotaping(KT) applied to the cervical spine on neck pain, ROM, and disability in patients following thyroidectomy. Materials and methods: A total of 74 patients were randomly assigned to be treated with either KT (Group 1, n = 37) or sham taping (Group 2, n = 37) …

Obesity Perception Survey Among Youth In Turkey: Instrument Development And Test-Retest Reliability, Wasantha Jayawardene, Sali̇h Pinar, Mohammad Torabi, Pengcheng Xun, Mustafa Kami̇l Özer

Turkish Journal of Medical Sciences

Background/aim: We aimed to develop an instrument that can assess the perceptions and opinions of young people regarding the causes and consequences of obesity and the role of individuals, families, communities, and government in addressing obesity.Materials and methods: A 36-question (101-item) survey was developed by adopting, translating, and revising multiple-choice or Likert-scale questions from existing surveys to assure construct cross-cultural validity. A two-factor mixed-effects model estimated the intraclass correlation coefficient (ICC) to measure the test-retest reliability of questions administered 2 weeks apart to a convenient sample of İstanbul high school and university students, aged 15?25 years (n = 122).Results: The …

Intensive Care Psychological Assessment Tool (Ipat): Turkish Validity And Reliability Study, Berker Duman, Zeynep Kotan, Vahap Ozan Kotan, Nevzat Mehmet Mutlu, Beyza Doğanay Erdoğan, Damla Sayar Akaslan, Safi̇ye Zeynep Tatli, Hakan Kumbasar

Turkish Journal of Medical Sciences

Background/aim: It is of crucial importantance to be able to detect acute psychological distress in patients. The Intensive Care Psychological Assessment Tool (IPAT) was developed for this purpose in intensive care units. This study aims to evaluate the validity and reliability of the Turkish version of IPAT.Materials and methods: In total, 98 patients were included. To assess concurrent validity, the Intensive Care Experiences Scale (ICES) and the Hospital Anxiety Depression Scale were performed. Cronbach?s alpha coefficient was used to estimate internal consistency. Interitem and item-total score correlations were also performed. Sensitivity and specificity were derived for concurrent anxiety and depression.Results: …

Validity And Reliability Study Of The Turkish Version Of The Hand20 Questionnaire, Nurten Gi̇zem Tore, Deran Oskay

Turkish Journal of Medical Sciences

Background/aim: This study aimed to translate and validate the Turkish version of the Hand20 questionnaire.Materials and methods: Patients who had upper extremity involvement and stable symptoms for the previous 4 weeks in their upper extremities were included in the study. Patients who were illiterate or used a splint during the day were excluded from the study. Participants completed the Turkish version of the Disabilities of the Arm, Shoulder, and Hand (DASH-T) questionnaire once and the final version of the Hand20 questionnaire twice in a 7-day interval. Internal consistency and reliability of the questionnaire was assessed. Moreover, correlations between Hand20 and …

Mechanism Of Nanogp8 In Glioblastoma Multiforme, Jonhoi Smith

Electronic Theses and Dissertations

Glioblastoma multiforme (GBM) is an incurable brain tumor, with patients only expecting to live 15 to 16 months post-diagnosis with the most current treatments options including surgery, chemotherapy, and radiation. How GBM resist treatment is still not very well known. However, cancer stem cells (CSCs), a subset of cells in GBM tissue considered responsible for therapeutic resistance and the poor patient prognosis. NANOG, a homeobox gene, is responsible for maintaining pluripotency of embryonic stem cells and is observed in CSCs. NANOGP8, a retrogene in the NANOG family is expressed in CSCs and provides cells with stem-like characteristics previously observed in …

Development Of A Functional Testing Platform For The Sensory Segment Of The Neuromuscular Reflex Arc, Alisha Colon

Electronic Theses and Dissertations

Investigations of human biology and disease have been hindered by the use of animal models. The information obtained from such studies often results in clinically irrelevant results and drug trial failures. Additionally, several governing bodies have been formulating legislation to move away from animal models and toward more ethical and efficient testing platforms for drug discovery and cosmetic research. As an answer to these issues, "body-on-a-chip" systems have been a rapidly developing field which easily recapitulates in vivo functionality, providing a more relevant, repeatable, and ethical testing platform to better predict biology. These systems can be used as human-based testing …

Health Care Evolves From Reactive To Proactive., Scott A. Waldman, Andre Terzic

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Decoding health and disease pathways drives healthcare evolution. Historically, therapeutic paradigms have relied on interventions that mitigate symptoms of established diseases. Increasingly, molecular insights into pathophysiology now provide unprecedented opportunities to offer curative solutions or even prevent disease and thereby secure longitudinal wellness. These opportunities extend past individual patients to entire populations and geographies. Moreover, they optimize prospective healthspan across lifespan. Linking discovery science and its translatable innovations beyond reactive disease intervention to proactive prevention will maximize society’s returns creating the greatest benefit for the greatest number of people globally.

Resistance Training Volume Enhances Muscle Hypertrophy But Not Strength In Trained Men, Brad J. Schoenfeld, Bret Contreras, James Krieger, Jozo Grgic, Kenneth Delcastillo, Ramon Belliard, Andrew Alto

Publications and Research

Purpose: The purpose of this study was to evaluate muscular adaptations between low-, moderate-, and high-volume resistance training protocols in resistance-trained men.

Methods: Thirty-four healthy resistance-trained men were randomly assigned to one of three experimental groups: a low-volume group performing one set per exercise per training session (n = 11), a moderate-volume group performing three sets per exercise per training session (n = 12), or a high-volume group performing five sets per exercise per training session (n = 11). Training for all routines consisted of three weekly sessions performed on nonconsecutive days for 8 wk. Muscular strength was evaluated with …

Long-Term Outcomes Of Neonatal Herpes Simplex Virus Infection And Treatment, Genesis M. Brador

Honors Undergraduate Theses

The prevalence of herpes simplex virus (HSV) infection globally is high, and although there is no cure for it, the antiviral drug acyclovir is used to alleviate symptoms. There are two types of HSV: HSV-1, which typically infects the oral area, and HSV-2, which is associated with genital infections. A mother who carries the infection may transmit it to a neonate in different ways, most commonly via vaginal delivery in the presence of active lesions. There are three types of HSV disease that affect newborns: skin, eyes or mouth (SEM) disease, central nervous system (CNS) disease, or disseminated disease. The …

Best Practices In Patellar Tendinopathy Management: An Evidence To Practice Review, Christopher J. Burcal, Adam B. Rosen, Tony Taylor, Mike Nicola

Clinical Practice in Athletic Training

Patellar tendinopathy (PT) is a degenerative condition that is common in sporting populations due to the loads placed on the tendon during dynamic activity. PT often occurs in overtraining situations; however, it may also occur in conjunction with and/or worsen through poor biomechanics, persistent inflammation, and altered movement patterns. Although sports medicine practitioners have evidence to support the prevalence of this injury, we do not have a strong base of evidence surrounding the contributing factors and pathophysiology that lead the pain and disability reported in patients with PT. The purpose of this evidence to practice review was to summarize a …

Model-Based Methods To Translate Adolescent Medicine Trials Network For Hiv/Aids Interventions Findings Into Policy Recommendations: Rationale And Protocol For A Modeling Core (Atn 161), Anne M. Neilan, Kunjal Patel, Allison L. Agwu, Ingrid V. Bassett, K. Rivet Amico, Catherine M. Crespi, Aditya H. Gaur, Keith J. Horvath, Kimberly A. Powers, H. Jonathon Rendina, Lisa B. Hightow-Weidman, Xiaoming Li, Sylvie Naar, Sharon Nachman, Jeffrey T. Parsons, Kit N. Simpson, Bonita F. Stanton, Kenneth A. Freedberg, Audrey C. Bangs, Michael G. Hudgens, Andrea L. Ciaranello

Publications and Research

BACKGROUND: The United States Centers for Disease Control and Prevention estimates that approximately 60,000 US youth are living with HIV. US youth living with HIV (YLWH) have poorer outcomes compared with adults, including lower rates of diagnosis, engagement, retention, and virologic suppression. With Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) support, new trials of youth-centered interventions to improve retention in care and medication adherence among YLWH are underway.

OBJECTIVE: This study aimed to use a computer simulation model, the Cost-Effectiveness of Preventing AIDS Complications (CEPAC)-Adolescent Model, to evaluate selected ongoing and forthcoming ATN interventions to improve viral load suppression …

ความเที่ยงตรงและความน่าเชื่อถือของคะแนนรวมอาการผิดปกติของระบบประสาทอัตโนมัติฉบับภาษาไทยสำหรับผู้ป่วยโรคเส้นประสาทอัตโนมัติพิการในผู้ป่วยนอกคลินิกอายุรกรรมประสาทโรคเส้นประสาทและกล้ามเนื้อ โรงพยาบาลจุฬาลงกรณ์, ชไมพร เตชะกำพุ

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์ เพื่อทดสอบความเทียงตรงและความเชื่อมั่นด้วยการสอบซ้ำของแบบสอบถามคะแนนรวมอาการผิดปกติระบบประสาทอัตโนมัติฉบับภาษาไทย (Composite Autonomic Symptom Score 31, Thai-COMPASS 31) วิธีการวิจัย ผู้วิจัยขออนุญาตและแปลแบบสอบถาม COMPASS 31 ฉบับภาษาอังกฤษต้นฉบับเป็นภาษาไทย (Thai-COMPASS 31) ที่มีความทัดเทียมเชิงเนื้อหาและวัฒนธรรม แล้วนำมาทดสอบกับผู้ป่วยโรคเส้นประสาทอัตโนมัติพิการที่มีอาการคงที่และได้ตรวจระบบประสาทอัตโนมัติทางห้องปฏิบัติการครบถ้วนภายในระยะเวลา 12 เดือน และมีคะแนนรวม Composite Autonomic Severity Score (CASS) ตั้งแต่ 1 คะแนนขึ้นไป ผู้เข้าร่วมวิจัยตอบแบบสอบถาม Thai-COMPASS 31 ฉบับเดิมด้วยตนเอง 2 ครั้งห่างกัน 2 สัปดาห์ ผู้วิจัยทดสอบความเที่ยงตรงของคะแนนรวม Thai-COMPASS 31 ครั้งที่ 1 และคะแนนรวม CASS ในผู้ป่วยจำนวน 47 คน และทดสอบความเชื่อมั่นด้วยวิธีสอบซ้ำด้วยคะแนนรวม Thai-COMPASS 31 ทั้ง 2 ครั้ง กับผู้ป่วยจำนวน 42 คน และเปรียบเทียบคะแนนรวม Thai-COMPASS 31 ครั้งที่ 1 ในแต่ละกลุ่มย่อยของลักษณะประชากรพื้นฐาน ผลการศึกษา คะแนนรวม CASS มีความสัมพันธ์ทางบวกกับคะแนนรวม Thai-COMPASS 31 อย่างมีนัยสำคัญทางสถิติ (rs = 0.347; p<0.05) คะแนนรวม Thai-COMPASS 31 ทั้ง 2 ครั้งมีความสัมพันธ์กันทางบวกระดับสูงอย่างมีนัยสำคัญทางสถิติ (rs = 0.801; p<0.001) ค่ามัธยฐานเวลาที่ใช้ตอบแบบสอบถามเท่ากับ 7 นาที (IQR: 6,8) และไม่พบว่าคะแนนรวม Thai-COMPASS 31 มีความแตกต่างอย่างมีนัยสำคัญทางสถิติ (p<0.05) ระหว่างกลุ่มย่อยลักษณะประชากรพื้นฐาน สรุป การศึกษานี้แสดงให้เห็นว่าแบบสอบถาม Thai-COMPASS 31 มีความเที่ยงตรงเมื่อเทียบกับคะแนนรวม CASS ซึ่งเป็นตัววัดมาตรฐาน และมีความเชื่อมั่นเมื่อทดสอบซ้ำ คะแนนรวม Thai-COMPASS 31 สามารถนำไปใช้กับประชากรไทยทั่วไปที่มีโรคเส้นประสาทอัตโนมัติพิการได้