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Biochemical And Cellular Mechanisms For The Antineoplastic Properties Of Sulindac, Jason Derek Whitt Jan 2012

Biochemical And Cellular Mechanisms For The Antineoplastic Properties Of Sulindac, Jason Derek Whitt

All ETDs from UAB

ABSTRACT The nonsteroidal anti-inflammatory drug (NSAID) sulindac has displayed the ability to inhibit the proliferation of colorectal cancer (CRC) cells and to increase the sensitivity of multidrug resistant (MDR) cancer cells to a wide variety of chemotherapeutic agents. The antineoplastic activity of sulindac has been attributed to inhibition of the prostaglandin producing enzyme COX-2, but the exact mechanism remains elusive and the inhibition of prostaglandin synthesis can result in gastrointestinal, hepatic, and cardiovascular toxicities. Enzymatic, cellular, and imaging assays were used to identify mechanisms that could contribute to the antiproliferative and apoptotic activity of sulindac. Screening of more than 500 …

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Antiphagocytic Factors Of Mycoplasma Pulmonis, Brandon Michael Shaw Jan 2012

Antiphagocytic Factors Of Mycoplasma Pulmonis, Brandon Michael Shaw

All ETDs from UAB

Mycoplasma pulmonis is a murine respiratory pathogen and is used as a model for studying chronic mycoplasmal respiratory disease. This organism has been used by many in vivo and in vitro studies to gain a better understanding of host-pathogen interactions in chronic respiratory infection. Studies have shown that alveolar macrophages play an important role in the removal of this pathogen from the host. Given that M. pulmonis is able to produce a chronic disease state, this organism should produce antiphagocytic factors that aid in avoidance of killing by alveolar macrophages. The Vsa proteins are involved in the avoidance of killing …

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Structural And Molecular Studies Of Nucleic Acid Chaperones, Lei Ding Jan 2012

Structural And Molecular Studies Of Nucleic Acid Chaperones, Lei Ding

All ETDs from UAB

Nucleic acids are the storage of genetic information that needs to be expressed and inherited. As abundant cellular macromolecules they are also major players of a wide variety of biological processes. They usually undergo post-transcriptional modifications and/or fold into higher order structures in order to accomplish their distinct functions. Most biological events involving nucleic acids are achieved by proteins that interact with them. The functionality requires specific recognition of nucleic acids by proteins at molecular level. Nucleic acid chaperones are a group of nucleic acids binding proteins that associate with structured RNAs or DNAs and assist correct folding of their …

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Modulation Of Autoimmune Diabetes By B Cells Specific For N-Acetyl-D-Glucosamine, Brian L. Dizon Jan 2012

Modulation Of Autoimmune Diabetes By B Cells Specific For N-Acetyl-D-Glucosamine, Brian L. Dizon

All ETDs from UAB

Type I diabetes (T1D) is an autoimmune disease in which ß cells are destroyed by the immune system; however, role of infections in type I diabetes (T1D) pathogenesis is unclear. Reports suggesting that childhood Group A Streptococcal (GAS) infections protected against T1D prompted us to study how antibodies to N-acetyl-D-glucosamine (GlcNAc), which are induced by GAS infection, influenced T1D development. We found that GlcNAc-specific antibodies reacted with ß cell secretory granules, and neonatal NOD mice immunized with GAS or given GAS-immune sera were protected from spontaneous diabetes. Monoclonal GlcNAc-specific IgM blocked activation and effector responses to islet antigens by diabetogenic …

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A Yeast Model For High Throughput Screening Of Gene-Gene Interactions Relevant To Cftrδf508 Protein Biogenesis, Jingyu Guo Jan 2012

A Yeast Model For High Throughput Screening Of Gene-Gene Interactions Relevant To Cftrδf508 Protein Biogenesis, Jingyu Guo

All ETDs from UAB

Much remains unknown about gene interaction in the context of human disease. In cystic fibrosis (CF) a single mutation of the cystic fibrosis transmembrane conductance regulator (CFTR-deltaF508) accounts for most disease. In cell models, CFTR-deltaF508 causes defective protein biogenesis and degradation rather than proper trafficking to the plasma membrane where CFTR normally functions in ion transport. Numerous genes function in the biogenesis of CFTR and influence the fate of CFTR-deltaF508 in cell models. However it is not known whether natural genetic variation in such genes contributes to disease severity in patients. Moreover, there is no easy way to predict how …

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Hcn Channels And Regulation Of Neocortical Network Activity, Asher Albertson Jan 2012

Hcn Channels And Regulation Of Neocortical Network Activity, Asher Albertson

All ETDs from UAB

Hyperpolarization activated non-specifc cation (HCN) channels are unique channels that activate following membrane hyperpolarization. Expressed primarily along the apical dendrites of pyramidal neurons, they pass a non-inactivating, inward current (Ih). HCN channel activation at resting membrane potentials profoundly impacts the synaptic and intrinsic properties of pyramidal neurons. Activated channels decrease intrinsic membrane excitability, hyperpolarize the resting membrane potential, and increase excitatory post-synaptic potentials (EPSP) summation. Loss of HCN channels is commonly observed in models of epilepsy. This dissertation tests the hypothesis that the influence of HCN channels on individual neuron excitability translates to an influence on network excitability. Furthermore, we …

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Modulation Of Wzy-Dependent Capsule Production In Streptococcus Pneumoniae By The Phosphotyrosine-Specific Phosphatase Cpsb, Kimball Aaron Geno Jan 2012

Modulation Of Wzy-Dependent Capsule Production In Streptococcus Pneumoniae By The Phosphotyrosine-Specific Phosphatase Cpsb, Kimball Aaron Geno

All ETDs from UAB

Biosynthesis of capsule polysaccharide in the Gram-positive pathogen Streptococcus pneumoniae is regulated in part through the action of a phosphoregulatory system comprised of the products of the capsule biosynthetic operon genes cpsBCD. CpsC and CpsD together comprise an autophosphorylating tyrosine kinase whose homologs are implicated in chain length regulation in other systems in both Gram-positive and Gram-negative organisms. CpsB is the cognate phosphatase for the system. Unlike Gram-negative organisms, which use a low molecular weight phosphotyrosine phosphatase in phosphoregulation of capsule synthesis, Gram-positive organisms utilize a polymerase and histidinol phosphatase (PHP) superfamily phosphatase. Deletion of cpsB has resulted in conflicting …

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Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix Jan 2012

Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix

All ETDs from UAB

The facultative pathogen Streptococcus pneumoniae is capable of producing a polysaccharide (PS) capsule that prevents bacterial recognition and clearance by the host immune system. Over 90 antigenically distinct capsule serotypes have been identified. Because anti-capsule antibodies can mediate bacterial clearance, capsule diversity is critical to S. pneumoniae survival. However, the mechanisms of capsule evolution remain unclear. Due to the complex interaction of capsule synthesis (cps) genes, it is commonly thought that pneumococcal serotypes evolve once and that all clinically relevant serotypes are genetically derived from a single founding clone. In this dissertation we demonstrate a novel mechanism of capsule evolution …

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Cytokine Signaling In A Mouse Model Of Parkinson's Disease, Shuwen Cao Jan 2012

Cytokine Signaling In A Mouse Model Of Parkinson's Disease, Shuwen Cao

All ETDs from UAB

The protein alpha-synuclein (α-SYN), which is found in the Lewy bodies of dopaminergic (DA) neurons in the substantia nigra (SN), has an important role in the pathogenesis of Parkinson's disease (PD). Fcγ receptors (FcγR) are proteins present on the surface of microglia, which bind immunoglobulin G (IgG) and other ligands. Our studies in an AAV-synuclein mouse model of PD showed that over-abundance of α-SYN triggered the expression of NF-κB p65, and led to microglial activation and DA neurodegeneration; however, in mice deficient of gamma chain subunit of the Fc receptors (FcγR-/- mice), α-SYN-induced NF-κB signaling was blocked, while microglial activation …

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Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa Jan 2012

Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa

All ETDs from UAB

A precise molecular identification of transmitted/founder (T/F) HIV-1 genomes responsible for productive infection in humans can be an enabling strategy for elucidating mechanisms of virus transmission, immunopathogenesis and prevention. Previously, we reported a single genome sequencing approach, which when combined with a mathematical model of early random virus diversification, allowed for an unambiguous identification of T/F HIV-1 subtype B and C envelope (env) genes. Here, we apply this method to the identification and molecular cloning of full-length HIV-1 genomes and env genes of the less well-studied, but nonetheless important, HIV-1 subtypes A and D. Twelve subtype A (n=5), D (n=5) …

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A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger Jan 2012

A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger

All ETDs from UAB

Parkinson's Disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. Gene multiplication of alpha-synuclein causes an autosomal dominant inheritance pattern of PD. A mouse model overexpressing alpha-synuclein demonstrates some of the phenotype seen in PD. In a microarray of these mice, a downregulation of angiogenin was observed prior to symptom onset, demonstrating a potential link of angiogenin to pathology in this model. Angiogenin has also been associated with the onset of Amyotrophic Lateral Sclerosis (ALS), and is neuroprotective in models of ALS through activation of the Akt …

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Contribution Of The Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (Erpc) To Complement Resistance Of Borrelia Burgdorferi, Claudia Hammerschmidt, Teresia Hallström, Christine Skerka, Reinhard Wallich, Brian Stevenson, Peter F Zipfel, Peter Kraiczy Jan 2012

Contribution Of The Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (Erpc) To Complement Resistance Of Borrelia Burgdorferi, Claudia Hammerschmidt, Teresia Hallström, Christine Skerka, Reinhard Wallich, Brian Stevenson, Peter F Zipfel, Peter Kraiczy

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs). Here, we extend our analyses to the contribution of CRASP-4 in mediating complement resistance of B. burgdorferi and its interaction with human complement regulators. CRASP-4 (also known as ErpC) was immobilized onto magnetic beads and used to capture proteins from human serum. Following Western blotting, factor H (CFH), CFH-related protein 1 (CFHR1), CFHR2, and CFHR5 were identified as ligands of CRASP-4. To analyze the impact of native CRASP-4 on mediating survival of serum-sensitive cells in human serum, a B. garinii strain was generated …

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Quantitative Reagent-Free Detection Of Fibrinogen Levels In Human Blood Plasma Using Raman Spectroscopy, Kelvin Poon, Fiona Lyng, Peter Knief, Orla L. Howe, Aidan Meade, James Curtin, Hugh Byrne, Joseph Vaughan Jan 2012

Quantitative Reagent-Free Detection Of Fibrinogen Levels In Human Blood Plasma Using Raman Spectroscopy, Kelvin Poon, Fiona Lyng, Peter Knief, Orla L. Howe, Aidan Meade, James Curtin, Hugh Byrne, Joseph Vaughan

Articles

Fibrinogen assays are commonly used as part of clinical screening tests to investigate haemorrhagic states, for detection of disseminated intravascular coagulation and as a predictor of a variety of cardiovascular events. The Clauss assay, which measures thrombin clotting time, is the most commonly used method for measuring fibrinogen levels. Nevertheless, inconsistencies are present in inter-manufacturer reagent sources, calibration standards and methodologies. Automated coagulation analysers, which measure changes in optical density during the prothrombin time (PT-Fg), have found use in many hospitals. However, the PT-Fg method is found to give falsely elevated values due to varying choices of calibrants, reagents and …

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Neuroangiogenesis: A Vascular Basis For Alzheimer's Disease And Cognitive Decline During Aging, Charles T. Ambrose Jan 2012

Neuroangiogenesis: A Vascular Basis For Alzheimer's Disease And Cognitive Decline During Aging, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Angiogenesis directs development of the brain's microcirculation during antenatal and postnatal development, but its role later in life is less well recognized. I contend that during senescence a reduced cerebral capillary density accounts in part for the vascular cognitive impairment observed in many older persons and possibly for some forms of Alzheimer's disease. I propose that neuroangiogenesis is essential throughout adult life for maintaining the microcirculation of the cerebral cortex and elsewhere in the brain and that it commonly declines with old age. To support this hypothesis I have examined the neurological literature for relevant studies on cerebral capillary density …

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A Comparative Study Of Preoperative Versus Intraoperative Meperidine Administration In Patients Receiving General Anesthesia: A Prospective, Randomized Double-Blind Study, Hüseyi̇n Sert, Rüveyda İrem Demi̇rci̇oğlu, Burhanetti̇n Usta, Bünyami̇n Muslu, Ümmügülsüm Yazici, Muhammet Gözdemi̇r, Önder Sürgi̇t Jan 2012

A Comparative Study Of Preoperative Versus Intraoperative Meperidine Administration In Patients Receiving General Anesthesia: A Prospective, Randomized Double-Blind Study, Hüseyi̇n Sert, Rüveyda İrem Demi̇rci̇oğlu, Burhanetti̇n Usta, Bünyami̇n Muslu, Ümmügülsüm Yazici, Muhammet Gözdemi̇r, Önder Sürgi̇t

Turkish Journal of Medical Sciences

To evaluate the effects of preoperative and intraoperative administration of intravenous meperidine as a preemptive analgesic. Materials and methods: A total of 50 patients were randomly divided into 2 groups; group P received 1 mg/kg of meperidine intravenously immediately before induction of anesthesia, and group I received the same amount of meperidine 20 min before completion of surgery. Consumption of desflurane, recovery parameters, heart rate, mean arterial pressure, sedation scores, visual analog scale (VAS) scores for pain, analgesic needs, and anesthesia-related complications were recorded for both groups. Results: Time to recovery was significantly shorter in group P than in group …

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Skin Prick Test Results And Prevalence Of Allergic Symptoms In Workers Exposed To Toluene, İsmai̇l Karabulut, Tevfi̇k Pinar, Hayri̇ye Karabulut, Meli̇ke Demi̇r, Güli̇stan Karadeni̇z, Riza Murat Karaşen Jan 2012

Skin Prick Test Results And Prevalence Of Allergic Symptoms In Workers Exposed To Toluene, İsmai̇l Karabulut, Tevfi̇k Pinar, Hayri̇ye Karabulut, Meli̇ke Demi̇r, Güli̇stan Karadeni̇z, Riza Murat Karaşen

Turkish Journal of Medical Sciences

To determine the distribution of allergens and allergic symptoms according to occupation groups in those who were exposed to toluene and presented with allergic rhinitis symptoms. Materials and methods: Of the 2005 patients who were administered an allergy test with the prediagnosis of allergic rhinitis, the files of 138 patients who were exposed to toluene were analyzed retrospectively. Results: The mean age of the patients was 35 ± 10 years. Distributions of symptoms and allergens of 57 patients (41.3%) with negative skin prick test and 81 patients (58.7%) with positive skin prick test were analyzed according to occupation groups. There …

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Effects Of Right And Left Stellate Ganglion Block On Blood Pressure And Qt-Qtc Intervals In Patients With Primary Raynaud's Phenomenon, Suna Akin Takmaz, Hale Yarkan Uysal, Nurten İnan, Zekeri̇ye Kaptan, Hülya Başar Jan 2012

Effects Of Right And Left Stellate Ganglion Block On Blood Pressure And Qt-Qtc Intervals In Patients With Primary Raynaud's Phenomenon, Suna Akin Takmaz, Hale Yarkan Uysal, Nurten İnan, Zekeri̇ye Kaptan, Hülya Başar

Turkish Journal of Medical Sciences

To examine the effects of right and left stellate ganglion block (SGB) on blood pressure and the RR, QT, and QTc intervals in patients with primary Raynaud's phenomenon. Materials and methods: Right and left SGBs were performed with 8 mL of 0.5% bupivacaine in 10 patients with primary Raynaud's phenomenon. There was an interval of at least 1 week between the right and left blocks of each patient. The blood pressure and the RR and QT intervals were measured before the block and 5, 10, 15, 20, and 30 min after the block. The QTc interval was calculated using Bazett's …

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Results Of Robotic Radical Prostatectomy In The Hands Of Surgeons Without Previous Laparoscopic Radical Prostatectomy Experience, Abdullah Erdem Canda, Ali̇ Fuat Atmaca, Zi̇ya Akbulut, Erem Asi̇l, Meti̇n Kiliç, Abi̇di̇n Egemen İşgören, Mevlana Derya Balbay Jan 2012

Results Of Robotic Radical Prostatectomy In The Hands Of Surgeons Without Previous Laparoscopic Radical Prostatectomy Experience, Abdullah Erdem Canda, Ali̇ Fuat Atmaca, Zi̇ya Akbulut, Erem Asi̇l, Meti̇n Kiliç, Abi̇di̇n Egemen İşgören, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

We report our initial experience related with robot-assisted laparoscopic radical prostatectomy (RALRP) performed by a urologic surgeon without previous laparoscopic radical prostatectomy (LRP) experience. Materials and methods: The data of the first 70 patients who underwent RALRP between February 2009 and February 2010 are presented. Results: Mean console time was 214 ± 55.5 min with pelvic lymph node dissection (LND) in 14 patients. Mean intraoperative blood loss was 215 ± 227.3 cc. Fourteen patients had positive surgical margins: pT3 (n = 12) and pT2 (n = 2). Lodge drains and urethral catheters were removed at a mean of 2.9 ± …

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Dietary Boron Intake Does Not Change The Ischemic Tolerance And Preconditioning Response In Isoproterenol-Induced Myocardial Injury In Healthy Rats, Mehmet Fati̇h Karakaş, Mustafa Kurt, Uğur Arslantaş, Göktürk İpek, Esra Karakaş, Emi̇ne Bi̇len, Hüsametti̇n Erdamar Jan 2012

Dietary Boron Intake Does Not Change The Ischemic Tolerance And Preconditioning Response In Isoproterenol-Induced Myocardial Injury In Healthy Rats, Mehmet Fati̇h Karakaş, Mustafa Kurt, Uğur Arslantaş, Göktürk İpek, Esra Karakaş, Emi̇ne Bi̇len, Hüsametti̇n Erdamar

Turkish Journal of Medical Sciences

Boron is important for many enzymes, most of which also have a role in the ischemic tolerance of the myocardium. We aimed to evaluate the influence of dietary boron intake on ischemic tolerance in a rat model. Materials and methods: Rats were divided into 3 groups according to the ischemia protocol: Sham (S) (n = 20 total), ischemia only (Isc-only) (n = 40 total), and remote ischemic preconditioning + ischemia (RIPC+Isc) (n = 40 total) groups. These 3 groups were further divided into 4 according to the amount of daily dietary boron (

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The Role Of Hba1c As A Screening And Diagnostic Test For Diabetes Mellitus In Ankara, Zeynep Gi̇ni̇ş, Gülfer Öztürk, Rana Sirmali, Ali̇ Yalçindağ, Yakup Dülgeroğlu, Tuncay Deli̇başi, Namik Deli̇baş Jan 2012

The Role Of Hba1c As A Screening And Diagnostic Test For Diabetes Mellitus In Ankara, Zeynep Gi̇ni̇ş, Gülfer Öztürk, Rana Sirmali, Ali̇ Yalçindağ, Yakup Dülgeroğlu, Tuncay Deli̇başi, Namik Deli̇baş

Turkish Journal of Medical Sciences

This study investigated the value of HbA1c as a screening and diagnostic test for diabetes mellitus (DM) in high-risk Turkish individuals. Materials and methods: A total of 295 participants were successfully screened. Patients were divided into 4 groups based on their oral glucose tolerance test results, according to criteria put forth by the American Diabetes Association; 120 (40.7%) had normoglycemia, 44 (14.9%) had DM, 62 (21%) had impaired fasting glucose, and 69 (23.4%) had impaired glucose tolerance. Results: With a cut-off value for the diagnosis of DM of 6.1%, HbA1c had a sensitivity of 81.8% and a specificity of 80%, …

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The Efficacy Of Topical Testosterone Treatment On Preputial Microvessel Density In Distal Hypospadias, Mustafa Çağri Savaş, Şi̇ri̇n Başpinar, Levent Duman, Fatma Ni̇lgün Kapucuoğlu Jan 2012

The Efficacy Of Topical Testosterone Treatment On Preputial Microvessel Density In Distal Hypospadias, Mustafa Çağri Savaş, Şi̇ri̇n Başpinar, Levent Duman, Fatma Ni̇lgün Kapucuoğlu

Turkish Journal of Medical Sciences

To investigate the efficacy of topical testosterone treatment on the microvessel density (MVD) of hypospadiac prepuce. Materials and methods: The prepuces of 20 healthy children undergoing routine circumcision served as the control group, while the prepuces of 20 children undergoing hypospadias repair served as the hypospadias group. The hypospadias group was further divided into 2 equal subgroups (n = 10) as the hypospadias with or without testosterone treatment groups. The meatal locations were coronal and subcoronal in all of the patients with hypospadias. The prepuces were stained by immunohistochemical methods using panendothelial cell antigen CD31 in order to assay their …

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Nutritional Assessment Via Anthropometric And Biochemical Measurements With Stable Copd, Mehmet Meral, Ömer Araz, Eli̇f Yilmazel Uçar, Nusret Yilmaz, Ni̇hal Arzu Mi̇ri̇ci̇ Jan 2012

Nutritional Assessment Via Anthropometric And Biochemical Measurements With Stable Copd, Mehmet Meral, Ömer Araz, Eli̇f Yilmazel Uçar, Nusret Yilmaz, Ni̇hal Arzu Mi̇ri̇ci̇

Turkish Journal of Medical Sciences

Nutritional assessment is important for the management of chronic obstructive pulmonary disease (COPD). This study aims at investigating the relation between the anthropometric and biochemical parameters for nutritional assessment with pulmonary function tests in COPD. Materials and methods: This is a prospective, cross-sectional study. Thirty-nine patients with stable COPD were enrolled the study. We evaluated the anthropometric [body mass index (BMI), skinfold thickness (SFT), and arm muscle circumference (AMC)], biochemical [serum total protein, albumin, transferrin, and blood urea nitrogen (BUN)], and spirometric [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC] measurements, as well as …

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Effect Of Ovulation Induction On Qt Dispersion In Electrocardiography, Ayla Üçkuyu, Fai̇ka Ceylan Çi̇ftçi̇, Özgür Çi̇ftçi̇, Emel Ebru Özçi̇men, Erzat Toprak, Erdem Turhan Jan 2012

Effect Of Ovulation Induction On Qt Dispersion In Electrocardiography, Ayla Üçkuyu, Fai̇ka Ceylan Çi̇ftçi̇, Özgür Çi̇ftçi̇, Emel Ebru Özçi̇men, Erzat Toprak, Erdem Turhan

Turkish Journal of Medical Sciences

To investigate whether ovulation induction resulting in supra-physiological concentration range of ovarian hormones has an effect on interlead ventricular depolarization heterogeneity via QT dispersion measurements. Estrogens influence the duration of cardiac repolarization but there is no significant change in the QT interval duration within the range of physiological estradiol variations. Materials and methods: Included in the study were 40 subjects, in whom ovulation induction was planned, and 20 volunteers. During the study, a 12-lead electrocardiogram of each woman was carried out 3 times: for the first time on day 2-3 of the menstrual cycle (menstrual day), for the second time …

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A New Anthropometric Measurement Of Penile Length And Its Relation To Second And Fourth Digital Lengths, Mürsel Davarci, Ahmet Gökçe, Fati̇h Rüştü Yalçinkaya, Yusuf Seli̇m Kaya, Ebru Turhan, Murat Tutanç, Yunus Doğramaci, Mevlana Derya Balbay Jan 2012

A New Anthropometric Measurement Of Penile Length And Its Relation To Second And Fourth Digital Lengths, Mürsel Davarci, Ahmet Gökçe, Fati̇h Rüştü Yalçinkaya, Yusuf Seli̇m Kaya, Ebru Turhan, Murat Tutanç, Yunus Doğramaci, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

The development of digits is under the control of Hox genes, which also control the differentiation of the urogenital system. In the present study we evaluated the association between penile length and lengths of the second and fourth digits. Materials and methods: In this study, 1028 Turkish male primary school children from the Eastern Mediterranean Region of Turkey were included. Weight and height measurements were obtained in order to calculate the body mass index (BMI). Flaccid and stretched length of the penis was measured. The lengths of the second and fourth digits of the right hands were measured. Statistical analyses …

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Ileosigmoid Knotting In Pregnancy, Sabri̇ Selçuk Atamanalp Jan 2012

Ileosigmoid Knotting In Pregnancy, Sabri̇ Selçuk Atamanalp

Turkish Journal of Medical Sciences

Aim: Ileosigmoid knotting (ISK) is a rare event in pregnancy. This study reviewed the clinical outcomes of 3 pregnant patients with ISK and compared the characteristics of these pregnant women with 16 nonpregnant women. Materials and methods: The clinical records were reviewed retrospectively. Results: Three pregnant patients accounted for 4.2% of 72 total ISK patients and 15.8% of 19 female ISK patients. The ages of the patients were 35, 38, and 31 years (mean: 34.7 years). All of the patients were multiparous. Two patients (66.7%) were in the 3rd trimester and 1 (33.3%) was in the 2nd trimester. The mean …

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The Role Of Quantitative D-Dimer Levels In The Follow-Up And Differential Diagnosis Of Pulmonary Thromboembolism And Community-Acquired Pneumonia, Ayhan Varol, Nurdan Köktürk, Hati̇ce Kiliç, Müge Aydoğdu, Numan Nadi̇r Eki̇m Jan 2012

The Role Of Quantitative D-Dimer Levels In The Follow-Up And Differential Diagnosis Of Pulmonary Thromboembolism And Community-Acquired Pneumonia, Ayhan Varol, Nurdan Köktürk, Hati̇ce Kiliç, Müge Aydoğdu, Numan Nadi̇r Eki̇m

Turkish Journal of Medical Sciences

Aim: To identify the quantitative D-dimer levels in pulmonary thromboembolism (PTE) and hospitalized-community acquired pneumonia (CAP) patients, and to determine the alteration of D-dimer levels with anticoagulant or antibacterial therapy. It is not well known that the quantitative analysis of D-dimer has a role in the differential diagnosis of PTE from other diseases. Materials and methods: Serum D-dimer levels were measured and compared prospectively with a latex-enhanced immunoturbidimetric method at admission, before initiating any antibiotic or anticoagulant therapy and then at days 3, 10, and 30 of treatment in PTE and CAP patients. Results: A total of 80 patients (45 …

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Effect Of Cycloplegia On Refractive Errors Measured With Three Different Refractometers In School-Age Children, Ceyhun Arici, Adem Türk, Soner Keski̇n, Osman Meli̇h Ceylan, Fati̇h Mehmet Mutlu, Hali̇l İbrahi̇m Altinsoy Jan 2012

Effect Of Cycloplegia On Refractive Errors Measured With Three Different Refractometers In School-Age Children, Ceyhun Arici, Adem Türk, Soner Keski̇n, Osman Meli̇h Ceylan, Fati̇h Mehmet Mutlu, Hali̇l İbrahi̇m Altinsoy

Turkish Journal of Medical Sciences

Aim: To compare 3 different refractometers with and without cycloplegia and to examine whether the photorefractometer necessitates cycloplegia in the measurement of refractive errors. Materials and methods: Included in the study were 62 eyes of 31 pediatric patients. The refractive errors of all of the eyes were measured with and without cycloplegia using a table-top autorefractometer (Potec PRK-6000), hand-held autorefractometer (Nidek ARK-30), and photorefractometer (Plusoptix S08), respectively. The spherical power, cylindrical power, cylindrical axis, spherical equivalent, and interpupillary distance values obtained were statistically compared. Results: The average age of the patients was 10.03 ± 2.79 years. There were statistically significant …

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A Combination Therapy Of Half-Dose Verteporfin Photodynamic Therapy And Intravitreal Injection Of Ranibizumab For Chronic Central Serous Chorioretinopathy, Yasi̇n Toklu, Hasan Basri̇ Çakmak, Mücella Arikan Yorgun, Şule Berk Ergun, Şaban Şi̇mşek Jan 2012

A Combination Therapy Of Half-Dose Verteporfin Photodynamic Therapy And Intravitreal Injection Of Ranibizumab For Chronic Central Serous Chorioretinopathy, Yasi̇n Toklu, Hasan Basri̇ Çakmak, Mücella Arikan Yorgun, Şule Berk Ergun, Şaban Şi̇mşek

Turkish Journal of Medical Sciences

Aim: To study the combination treatment consisting of half-dose verteporfin photodynamic therapy (PDT) and an intravitreal injection of ranibizumab as a potential treatment for patients with chronic central serous chorioretinopathy (CSC). Materials and methods: Six eyes of 6 patients were studied with fundus examination, fluorescein angiography, and optical coherence tomography to diagnose the maculopathy, monitor the detachments, and localize the choroidal hyperpermeability of the disorder. Half-dose verteporfin PDT was applied to areas of choroidal hyperpermeability and, the following day, 0.5 mg/0.05 mL ranibizumab was injected intravitreally. The patients were observed to determine the anatomic and functional outcomes. Results: The combination …

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Effects Of Depression And Life Factors On Social Network Score In Elderly People In Çankaya, Ankara, Meti̇n Canbal, İrfan Şencan, Ayfer Şahi̇n, Şeyda Kunt, Umut Yücel Çavuş, Oğuz Teki̇n Jan 2012

Effects Of Depression And Life Factors On Social Network Score In Elderly People In Çankaya, Ankara, Meti̇n Canbal, İrfan Şencan, Ayfer Şahi̇n, Şeyda Kunt, Umut Yücel Çavuş, Oğuz Teki̇n

Turkish Journal of Medical Sciences

Aim: Social interaction is an important factor in the physical and mental health of seniors. This study was performed in order to evaluate the effects of depression and life factors on the social networking scores of elderly people. Materials and methods: Tests for the Lubben Social Network Scale (LSNS) and Geriatric Depression Scale (GDS) were given to 116 elderly people (>=60 years) in the Çankaya area of Ankara between March and May of 2010. The effects of life factors and GDS scores on LSNS scores were explored. Results: Among the study group, 46.5% of the individuals were male and …

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The Effect Of Early Loss Of Anterior Primary Tooth On Speech Production In Preschool Children, Melek Di̇lek Turgut, Gülsüm Aydan Genç, Fi̇gen Başar, Meryem Uzamiş Tekçi̇çek Jan 2012

The Effect Of Early Loss Of Anterior Primary Tooth On Speech Production In Preschool Children, Melek Di̇lek Turgut, Gülsüm Aydan Genç, Fi̇gen Başar, Meryem Uzamiş Tekçi̇çek

Turkish Journal of Medical Sciences

Early childhood caries (ECC) is a progressive dental caries in children that may cause premature loss of the anterior primary teeth. In this study, the aim was to investigate the effects of primary anterior tooth loss and removable dentures on the speech of children with ECC. Materials and methods: Included in the study were 15 patients with ECC who required extraction of the primary anterior teeth and needed dentures (case group), and 15 healthy children (control group). The articulation of the control group was evaluated once and that of the case group was evaluated before and after extraction, before and …

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