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Articles 10411 - 10440 of 13162
Full-Text Articles in Entire DC Network
Dissociation Of Metabolic And Hemodynamic Levodopa Responses In The 6-Hydroxydopamine Rat Model, R. P. Lerner, Z. Bimpisidis, S. Agorastos, S. Scherrer, S. L. Dewey, M. A. Cenci, D. Eidelberg
Dissociation Of Metabolic And Hemodynamic Levodopa Responses In The 6-Hydroxydopamine Rat Model, R. P. Lerner, Z. Bimpisidis, S. Agorastos, S. Scherrer, S. L. Dewey, M. A. Cenci, D. Eidelberg
Journal Articles
No abstract provided.
Removal From Play After Concussion And Recovery Time, R.J. Elbin, Alicia Sufrinko, Philip Schatz, Jon French, Luke Henry, Scott Burkhart, Michael W. Collins, Anthony P. Kontos
Removal From Play After Concussion And Recovery Time, R.J. Elbin, Alicia Sufrinko, Philip Schatz, Jon French, Luke Henry, Scott Burkhart, Michael W. Collins, Anthony P. Kontos
Faculty Publications - Doctor of Psychology (PsyD) Program
OBJECTIVE: Despite increases in education and awareness, many athletes continue to play with signs and symptoms of a sport-related concussion (SRC). The impact that continuing to play has on recovery is unknown. This study compared recovery time and related outcomes between athletes who were immediately removed from play and athletes who continued to play with an SRC. METHODS: A prospective, repeated measures design was used to compare neurocognitive performance, symptoms, and recovery time between 35 athletes (mean ± SD age, 15.61 ± 1.65 years) immediately removed after an SRC (REMOVED group) compared with 34 athletes (mean ± SD age, 15.35 …
Crispr/Cas9 As A Therapeutic Approach To Duchenne Muscular Dystrophy, Abraham Daniel Levitman
Crispr/Cas9 As A Therapeutic Approach To Duchenne Muscular Dystrophy, Abraham Daniel Levitman
The Science Journal of the Lander College of Arts and Sciences
Transhumanism, designer babies, gene therapy, and super-soldiers are founded upon the same concept—genetic engineering. Clustered Regularly-Interspersed Short Palindromic Repeats (CRISPR) is a natural bacterial immune response method that takes advantage of gene manipulation to prevent an infection from mobile genetic elements. Since Mojica et al. (2005) first suggested the relationship between the CRISPR/Cas system and prokaryotic immunity, significant advancements have been made in understanding the mechanism and subsequent applications of CRISPR. CRISPR, has three main subtypes based on unique proteins and interference pathways and serves as an accurate and effective method for gene editing. Its mechanism consists of spacer acquisition, …
Association Analysis Of Copy Numbers Of Fc-Gamma Receptor Genes For Rheumatoid Arthritis And Other Immune-Mediated Phenotypes, L. Franke, H. El Bannoudi, D. T. Jansen, K. Kok, G. Trynka, D. Diogo, M. Swertz, K. Fransen, P. K. Gregersen, A. Zhernakova, +16 Additional Authors
Association Analysis Of Copy Numbers Of Fc-Gamma Receptor Genes For Rheumatoid Arthritis And Other Immune-Mediated Phenotypes, L. Franke, H. El Bannoudi, D. T. Jansen, K. Kok, G. Trynka, D. Diogo, M. Swertz, K. Fransen, P. K. Gregersen, A. Zhernakova, +16 Additional Authors
Journal Articles
Segmental duplications (SDs) comprise about 5% of the human genome and are enriched for immune genes. SD loci often show copy numbers variations (CNV), which are difficult to tag with genotyping methods. CNV in the Fcgamma receptor region (FCGR) has been suggested to be associated with rheumatic diseases. The objective of this study was to delineate association of FCGR-CNV with rheumatoid arthritis (RA), coeliac disease and Inflammatory bowel disease incidence. We developed a method to accurately quantify CNV in SD loci based on the intensity values from the Immunochip platform and applied it to the FCGR locus. We determined the …
Loci Associated With N-Glycosylation Of Human Igg Are Not Associated With Rheumatoid Arthritis: A Mendelian Randomisation Study, A. Yarwood, S. Viatte, Y. Okada, R. Plenge, K. Yamamoto, A. Barton, D. Symmons, S. Raychaudhuri, P. Gregersen, S. Eyre, +2 Additional Authors
Loci Associated With N-Glycosylation Of Human Igg Are Not Associated With Rheumatoid Arthritis: A Mendelian Randomisation Study, A. Yarwood, S. Viatte, Y. Okada, R. Plenge, K. Yamamoto, A. Barton, D. Symmons, S. Raychaudhuri, P. Gregersen, S. Eyre, +2 Additional Authors
Journal Articles
OBJECTIVES: A recent study identified 16 genetic variants associated with N-glycosylation of human IgG. Several of the genomic regions where these single nucleotide polymorphisms (SNPs) reside have also been associated with autoimmune disease (AID) susceptibility, suggesting there may be pleiotropy (genetic sharing) between loci controlling both N-glycosylation and AIDs. We investigated this by testing variants associated with levels of IgG N-glycosylation for association with rheumatoid arthritis (RA) susceptibility using a Mendelian randomisation study, and testing a subset of these variants in a less well-powered study of treatment response and severity. METHODS: SNPs showing association with IgG N-glycosylation were analysed for …
What Is Damaging The Kidney In Lupus Nephritis?, A. Davidson
What Is Damaging The Kidney In Lupus Nephritis?, A. Davidson
Journal Articles
Despite marked improvements in the survival of patients with severe lupus nephritis over the past 50 years, the rate of complete clinical remission after immune suppression therapy is
Whole-Exome Sequencing In Relapsing Chronic Lymphocytic Leukemia: Clinical Impact Of Recurrent Rps15 Mutations, V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, N. Chiorazzi, R. Rosenquist, +24 Additional Authors
Whole-Exome Sequencing In Relapsing Chronic Lymphocytic Leukemia: Clinical Impact Of Recurrent Rps15 Mutations, V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, N. Chiorazzi, R. Rosenquist, +24 Additional Authors
Journal Articles
Fludarabine, cyclophosphamide and rituximab (FCR) is first-line treatment for medically fit chronic lymphocytic leukemia (CLL) patients, however despite good response rates many patients eventually relapse. Whilst recent high-throughput studies have identified novel recurrent genetic lesions in adverse-prognostic CLL, the mechanisms leading to relapse after FCR therapy are not completely understood. To gain insight into this issue, we performed whole-exome sequencing of sequential samples from 41 CLL patients who were uniformly treated with FCR but relapsed after a median of 2 years. In addition to mutations with known adverse-prognostic impact (TP53, NOTCH1, ATM, SF3B1, NFKBIE, BIRC3) a large proportion of cases …
Retinopathy Of Prematurity: Incidence, Risk Factors, And Evaluation Of Screening Criteria, Arzu Gebeşçe, Haşi̇m Uslu, Esengül Keleş, Aydin Yildirim, Bülent Gürler, Hamza Yazgan, Bülent Baştürk, Mehmet Demi̇rdöven, Alparslan Tonbul
Retinopathy Of Prematurity: Incidence, Risk Factors, And Evaluation Of Screening Criteria, Arzu Gebeşçe, Haşi̇m Uslu, Esengül Keleş, Aydin Yildirim, Bülent Gürler, Hamza Yazgan, Bülent Baştürk, Mehmet Demi̇rdöven, Alparslan Tonbul
Turkish Journal of Medical Sciences
Background/aim: The goal of this study was to investigate the incidence of retinopathy of prematurity (ROP) and the relationship between risk factors and disease in premature newborns in our neonatal intensive care unit. Materials and methods: A total of 219 premature subjects were retrospectively evaluated for retinopathy. Demographic information, clinical data, and risk factors were reviewed. Results: The gestational ages of the infants included in the study ranged between 25 and 36 weeks, and the birth weights ranged between 670 and 4460 g. In this study, the incidence of ROP was 20.1% (44) in preterm infants: 16 had stage 1 …
Fully Automated Morphological Analysis Of Patients With Obstructive Sleep Apnea, Oktay Alğin, Burak Akin, Gökhan Ocakoğlu, Evri̇m Özmen
Fully Automated Morphological Analysis Of Patients With Obstructive Sleep Apnea, Oktay Alğin, Burak Akin, Gökhan Ocakoğlu, Evri̇m Özmen
Turkish Journal of Medical Sciences
Background/aim: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by episodic hypoxia. We aimed to use the Freesurfer program for global evaluation of morphological changes in OSAS patients. Materials and methods: Three-dimensional T1-weighted images were obtained, and intracranial morphology was assessed in 18 patients with OSAS and 20 controls. Results of the volume and the cortical thickness analyses of both groups were compared statistically. Results: The total cortical, left-right hemispheres gray matter (GM), corpus callosum, and total GM volumes were lower in OSAS patients when compared with the control group (P < 0.001). The average cortical thickness was lower in OSAS patients bilaterally in pars orbitalis, paracentral, rostral middle frontal, middle frontal, orbital, and superior frontal gyri when compared with the control group (P < 0.05). Furthermore, the volume and average cortical thickness of multiple anatomic regions, apart from the brain parts mentioned above, were decreased unilaterally (e.g., hippocampus, cingulum, putamen, thalamus) in OSAS patients (P < 0.05). Conclusion: Multiple morphologic changes occur in the cerebral structures of OSAS patients due to intermittent ischemia episodes. Detection of those areas with Freesurfer is easier. New studies with large series would be needed for these subjects.
The Role Of Fdg Pet/Ct In Detection Of Distant Metastasis In Theinitial Staging Of Breast Cancer, Anar Aliyev, Sabi̇re Yilmaz Aksoy, Meftune Özhan, Özgül Ekmekçi̇oğlu, Betül Vatankulu, Pinar Çi̇ğdem Kocael, Muhammet Sai̇t Sağer, Meli̇h Engi̇n Erkan, Keri̇m Sönmezoğlu, Meti̇n Halaç
The Role Of Fdg Pet/Ct In Detection Of Distant Metastasis In Theinitial Staging Of Breast Cancer, Anar Aliyev, Sabi̇re Yilmaz Aksoy, Meftune Özhan, Özgül Ekmekçi̇oğlu, Betül Vatankulu, Pinar Çi̇ğdem Kocael, Muhammet Sai̇t Sağer, Meli̇h Engi̇n Erkan, Keri̇m Sönmezoğlu, Meti̇n Halaç
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the role of FDG PET/CT in the detection of extraaxillary regional nodal/distant metastasis in breast cancer patients and to assess the value of FDG PET/CT for detecting distant metastases in patient subgroups. Materials and methods: A total of 254 patients with breast cancer (248 female, 6 male) who underwent PET/CT for initial staging were enrolled. Patients were divided into four groups: Group 1 consisted of 154 patients diagnosed by tru-cut/core/FNAB, Group 2 comprised 32 patients diagnosed by excisional biopsy, Group 3 included 62 patients who had mastectomy-axillary lymph node dissection, and Group 4 consisted of …
Management Of Hyperbilirubinemia In Preterm Infants In Turkey, Ni̇lüfer Güzoğlu, Ümi̇t Ayşe Tandircioğlu, Di̇dem Ali̇efendi̇oğlu
Management Of Hyperbilirubinemia In Preterm Infants In Turkey, Ni̇lüfer Güzoğlu, Ümi̇t Ayşe Tandircioğlu, Di̇dem Ali̇efendi̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Prematurity is a significant risk factor for developing unconjugated hyperbilirubinemia. This study investigated the current approach to managing hyperbilirubinemia in preterm newborns in Turkey. Materials and methods: A study-specific questionnaire on the management of jaundice in preterm infants was sent to 100 level III neonatal intensive care units in Turkey. Results: Responses were obtained from 84 centers from all regions of Turkey. Of the centers, 75.3% used the Turkish Neonatology Society guidelines for deciding to start phototherapy, and 24.7% used different guidelines. The monitoring of bilirubin varied among the participants. Of the participants, 53.6% believed that prophylactic phototherapy was …
The Role Of Baseline Ga-68 Dotatate Positron Emission Tomography/Computed Tomography In The Prediction Of Response To Fixed-Dose Peptide Receptor Radionuclide Therapy With Lu-177 Dotatate*, Çi̇ğdem Soydal, Ahmet Peker, Elgi̇n Özkan, Nuri̇ye Özlem Küçük, Kemal Meti̇n Kir
The Role Of Baseline Ga-68 Dotatate Positron Emission Tomography/Computed Tomography In The Prediction Of Response To Fixed-Dose Peptide Receptor Radionuclide Therapy With Lu-177 Dotatate*, Çi̇ğdem Soydal, Ahmet Peker, Elgi̇n Özkan, Nuri̇ye Özlem Küçük, Kemal Meti̇n Kir
Turkish Journal of Medical Sciences
Background/aim: To describe the role of baseline gallium (Ga)-68 DOTATATE positron emission tomography (PET)/computed tomography (CT) in the prediction of the response to peptide receptor radionuclide therapy (PRRT) using lutetium (Lu)-177 DOTATATE. Materials and methods: Analysis was made of baseline Ga-68 DOTATATE PET/CT images of 29 patients (17 females and 12 males; mean age: 50.7 ± 14.6 years) with metastatic neuroendocrine tumors who received PRRT with Lu-177 DOTATATE. Maximum standardized uptake values (SUVmax) of reference lesions and their ratios to physiological uptake organs were calculated. The relationship between these values and the radiological response was analyzed. Results: Partial response was …
Posterior Laminoforaminotomy In The Treatment Of Lateralcervical Herniated Disc And Foraminal Stenosis, Hakan Yilmaz, Ali̇ Riza Ertürk, Ayşe Karataş, İbrahi̇m Burak Atci, Alaetti̇n Yurt
Posterior Laminoforaminotomy In The Treatment Of Lateralcervical Herniated Disc And Foraminal Stenosis, Hakan Yilmaz, Ali̇ Riza Ertürk, Ayşe Karataş, İbrahi̇m Burak Atci, Alaetti̇n Yurt
Turkish Journal of Medical Sciences
Background/aim: Posterior cervical laminoforaminotomy is an effective surgical treatment in selected cases of cervical radiculopathy caused by posterolateral herniated discs or foraminal stenosis. The aim of the present study was to evaluate the surgical techniques, rates of complications, long-term outcomes, advantages, and disadvantages of keyhole foraminotomy retrospectively. Materials and methods: Keyhole foraminotomy was performed in 83 patients. In 51 patients (61.5%) soft disc herniation was removed, and in 32 of them (38.5%) osteophytes were evident. The clinical data were evaluated according to Odom's criteria, and the mean follow-up time was 6 months. Results: Postoperative results were classed as excellent in …
The Role Of 18f-Fdg Pet-Ct In The Detection Of Unknown Primary Malignancy: A Retrospective Study, Olga Yaylali, Fatma Suna Kiraç, Doğangün Yüksel
The Role Of 18f-Fdg Pet-Ct In The Detection Of Unknown Primary Malignancy: A Retrospective Study, Olga Yaylali, Fatma Suna Kiraç, Doğangün Yüksel
Turkish Journal of Medical Sciences
Background/aim: This study aimed to retrospectively evaluate the role of 18F-FDG PET/CT imaging in the detection of unknown primary tumor sites in patients with a suspicious malignancy. Materials and methods: We retrospectively examined the 18F-FDG PET/CT images of 50 unknown primary malignancy patients. The malignancy of the lesions with increased 18F-FDG uptake on PET images was defined by interpreting the nondiagnostic CT images that were obtained with the PET study. The primary tumor site was decided according to the combined PET/CT findings, and the results were subsequently confirmed with a histopathological examination. Results: Fifty patients (29 M; 21 F) aged …
Free Radical-Induced Nephrotoxicity Following Repeated Oral Exposureto Chlorpyrifos Alone And In Conjunction With Fluoride In Rats, Naseer Baba, Rajinder Raina, Pawan Verma, Mudasir Sultana
Free Radical-Induced Nephrotoxicity Following Repeated Oral Exposureto Chlorpyrifos Alone And In Conjunction With Fluoride In Rats, Naseer Baba, Rajinder Raina, Pawan Verma, Mudasir Sultana
Turkish Journal of Medical Sciences
Background/aim: Chronic renal disorder is becoming a major health problem worldwide. The purpose of the present study was to investigate alterations in the renal antioxidant system in rats induced by repeated exposure to chlorpyrifos (CPF) alone and in conjunction with fluoride. Materials and methods: Wistar rats were randomly allocated to seven groups, each consisting of six rats, and were subjected to different treatment regiments for 28 days. Results: Significant increases (P < 0.05) in plasma protein, blood urea nitrogen, and creatinine levels indicated alterations in renal functions on repeated exposure to CPF or fluoride; moreover, these changes were more pronounced in animals exposed to both toxicants concurrently. A significant increase (P < 0.05) in malondialdehyde levels and decreases in superoxide dismutase, catalase, and glutathione peroxidase activities in renal tissue were noted, indicating renal damage on exposure to CPF, fluoride, or the combination of those. Conclusion: Our observations suggested that the concurrent exposure to CPF and fluoride increased the extent of renal damage. These findings indicate that this damage is due to increased free radical formation and a reduced function of the antioxidant system in renal tissue. Thus, the application of CPF as an insecticide should be reduced in areas where the fluoride levels in ground waters are high in order to minimize renal damage in exposed populations.
Evaluation Of The Effectiveness Of Biodegradable Electrospun Caprolactoneand Poly(Lactic Acid-?-Caprolactone) Nerve Conduits For Peripheral Nerveregenerations In A Rat Sciatic Nerve Defect Model, Mehmet Dadaci, Ni̇met Karagülle, Erhan Sönmez, Zeynep Dadaci, Evren Tevfi̇k İşci̇, Bi̇lsev İnce, İbrahi̇m Vargel, Erhan Pi̇şki̇n, Ali̇ Yücel Erk
Evaluation Of The Effectiveness Of Biodegradable Electrospun Caprolactoneand Poly(Lactic Acid-?-Caprolactone) Nerve Conduits For Peripheral Nerveregenerations In A Rat Sciatic Nerve Defect Model, Mehmet Dadaci, Ni̇met Karagülle, Erhan Sönmez, Zeynep Dadaci, Evren Tevfi̇k İşci̇, Bi̇lsev İnce, İbrahi̇m Vargel, Erhan Pi̇şki̇n, Ali̇ Yücel Erk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to compare electrospun caprolactone (EC) and poly(lactic acid-?-caprolactone) (PLCL) nerve conduits with nerve graft in a rat sciatic nerve defect model. Materials and methods: A total of 32 male Wistar albino rats were divided into 4 groups, with 8 rats in each group. A nerve defect of 1 cm was constructed in the left sciatic nerve of the rats. These defects were left denuded in the sham group, and reconstructed with nerve grafts, PLCL, and EC nerve conduits in the other groups. After 3 months, nerve regenerations were evaluated macroscopically, microscopically, and electrophysiologically. …
Seroprevalence Of Measles, Mumps, Rubella, And Varicella Amongphysicians And Nurses In Jordan, Faris Ghalib Bakri, Zakaria Mohammad Abdelrahim, Alqahira Samih Alkalbani, Ghada Mohammad Khrais, Deena Shamroukh, Ferial Ahmad Hayajneh, Azmi Mahafza
Seroprevalence Of Measles, Mumps, Rubella, And Varicella Amongphysicians And Nurses In Jordan, Faris Ghalib Bakri, Zakaria Mohammad Abdelrahim, Alqahira Samih Alkalbani, Ghada Mohammad Khrais, Deena Shamroukh, Ferial Ahmad Hayajneh, Azmi Mahafza
Turkish Journal of Medical Sciences
Background/aim: Measles, mumps, rubella, and varicella can affect susceptible healthcare workers who might subsequently spread the infection to susceptible patients and workers. Here, we aim to determine the seroprevalence of these infections among physicians and nurses and to compare the history of varicella with the results of varicella antibodies among study participants. Materials and methods: Two randomly selected groups, one group of physicians and one of nurses, from a university hospital in Jordan were interviewed and their serum IgG antibodies were measured. Results: The physicians and nurses group had 252 and 241 participants, respectively. The physicians group had significantly more …
The Relationship Of Breast Arterial Calcification Detected In Mammographic Examinations With Cardiovascular Diseases, Cardiovascular Risk Factors, Parity, And Breastfeeding, Kadi̇han Yalçin Şafak, Ayşegül Eratalay, Ebru Dülger İli̇ş, Nesli̇han Umarusman Tanju, Begüm Damla Şencan, Tamer Baysal
The Relationship Of Breast Arterial Calcification Detected In Mammographic Examinations With Cardiovascular Diseases, Cardiovascular Risk Factors, Parity, And Breastfeeding, Kadi̇han Yalçin Şafak, Ayşegül Eratalay, Ebru Dülger İli̇ş, Nesli̇han Umarusman Tanju, Begüm Damla Şencan, Tamer Baysal
Turkish Journal of Medical Sciences
Background/aim: We aimed to detect the incidence of breast arterial calcification (BAC) in patients that underwent mammography and to reveal the relationship of BAC with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding. Materials and methods: A total of 1195 female patients were included in this study. Cases that were positive for BAC during mammography were recorded. The relationship of BAC with age, body mass index, parity, breastfeeding, menopause, smoking, alcohol consumption, oral contraceptive use, hormone replacement therapy, and histories of hypertension (HT), diabetes mellitus (DM), coronary artery disease (CAD), and cerebral vascular diseases were investigated. Results: Overall, 97 of …
Treatment Of Mixed Astigmatism: Early Clinical Outcomes With Wavelight And Technolas Excimer Lasers, Ayşe Ebru Kilavuzoğlu, Tansu Gönen, Ali̇ Riza Cenk Çelebi̇, Cemi̇le Banu Coşar Yurteri̇, Asim Bozkurt Şener
Treatment Of Mixed Astigmatism: Early Clinical Outcomes With Wavelight And Technolas Excimer Lasers, Ayşe Ebru Kilavuzoğlu, Tansu Gönen, Ali̇ Riza Cenk Çelebi̇, Cemi̇le Banu Coşar Yurteri̇, Asim Bozkurt Şener
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the results of WaveLight Allegretto Wave Eye-Q 400 Hz and Technolas 217z100 excimer lasers in the treatment of mixed astigmatism. Materials and methods: Forty-nine patients who underwent laser in situ keratomileusis for mixed astigmatism were included in this retrospective study. Twenty-eight eyes of 21 patients were treated with WaveLight and 46 eyes of 28 patients were treated with the Technolas excimer laser. The patients' visual acuities and refractive values were evaluated on postoperative day 1 and at 1 and 3 months. Results: In the WaveLight and Technolas groups, cylindrical refractive errors at month 3 were …
Investigation Of Enteropathogenic Escherichia Coli And Shiga Toxin-Producing Escherichia Coli Associated With Hemolytic Uremic Syndrome In İzmir Province, Turkey, Eli̇f Bozçal, Gürkan Yi̇ği̇ttürk, Ataç Uzel, Sabi̇re Şöhret Aydemi̇r
Investigation Of Enteropathogenic Escherichia Coli And Shiga Toxin-Producing Escherichia Coli Associated With Hemolytic Uremic Syndrome In İzmir Province, Turkey, Eli̇f Bozçal, Gürkan Yi̇ği̇ttürk, Ataç Uzel, Sabi̇re Şöhret Aydemi̇r
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate Shiga toxin-producing Escherichia coli (STEC) and enteropathogenic Escherichia coli (EPEC) strains originating from diarrheagenic patients. Materials and methods: A total of 102 patients with diarrhea between October 2012 and January 2013 were enrolled in this study. Multiplex and standard polymerase chain reactions were performed to detect and distinguish STEC and EPEC strains. O serotyping of EPEC was carried out by monovalent antisera. The O and H serotyping of STEC strains was performed at the Refik Saydam Institute, Ankara. Results: A total of 5 (3.42%) strains were identified as STEC, and 3 …
Intravitreal Bevacizumab For Retinopathy Of Prematurity In Infants Ineligible For Laser Therapy, Ahmet Murad Hondur, Mehmet Özgür Çubuk, Zühal Özen Tunay, Hati̇ce Tuba Atalay, Özdemi̇r Özdemi̇r, İkbal Seza Petri̇çli̇, İhsan Gökhan Güreli̇k
Intravitreal Bevacizumab For Retinopathy Of Prematurity In Infants Ineligible For Laser Therapy, Ahmet Murad Hondur, Mehmet Özgür Çubuk, Zühal Özen Tunay, Hati̇ce Tuba Atalay, Özdemi̇r Özdemi̇r, İkbal Seza Petri̇çli̇, İhsan Gökhan Güreli̇k
Turkish Journal of Medical Sciences
Background/aim: To evaluate refractive and strabismic results and the efficacy of intravitreal bevacizumab in retinopathy of prematurity (ROP) ineligible for laser therapy. Materials and methods: Thirty-nine eyes of 20 consecutive infants with high-risk prethreshold ROP (11 infants with Zone I and 9 infants with Zone II disease) who were ineligible for laser therapy due to systemic and/or ocular conditions were treated with intravitreal bevacizumab. Recurrent retinopathy was treated with laser ablation. The final follow-up examination was performed at 29.8 ± 6.0 months of corrected age. Results: All eyes responded to the initial treatment with intravitreal bevacizumab. ROP recurred in 8 …
Nf-?? And Sod Expression In Preeclamptic Placentas, Abraham Silva Carmona, Hugo Mendieta Zeron
Nf-?? And Sod Expression In Preeclamptic Placentas, Abraham Silva Carmona, Hugo Mendieta Zeron
Turkish Journal of Medical Sciences
Background/aim: Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-?β) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background. Materials and methods: Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-?β and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2-ΔΔct analysis method was used to measure the difference in the relative expression …
The Effect Of Addition Of Ketamine To Lidocaine On Postoperative Pain In Rhinoplasties, Mukadder Şanli, Nurçi̇n Gülhaş, Bi̇lge Türk Bi̇len, Gülay Erdoğan Kayhan, Muharrem Uçar, Ahmet Hamdi̇ Ayteki̇n, Sai̇m Yoloğlu
The Effect Of Addition Of Ketamine To Lidocaine On Postoperative Pain In Rhinoplasties, Mukadder Şanli, Nurçi̇n Gülhaş, Bi̇lge Türk Bi̇len, Gülay Erdoğan Kayhan, Muharrem Uçar, Ahmet Hamdi̇ Ayteki̇n, Sai̇m Yoloğlu
Turkish Journal of Medical Sciences
Background/aim: The objective of this study was to examine the effect of addition of subanesthetic doses of ketamine to an epinephrine-lidocaine solution on postoperative pain, analgesic use, and patient comfort during rhinoplasties. Materials and methods: Ninety patients were randomly divided into three groups: Group L, lidocaine with epinephrine; Group K, lidocaine with epinephrine plus ketamine; and Group S (control group), physiological saline solution with epinephrine. The local anesthetic solution was injected as preincisionally with intranasal submucosal infiltration following induction of general anesthesia. We evaluated visual pain score, analgesic demand, Wilson sedation score, and antiemetic demand at 5, 15, and 30 …
Complications Of Tracheobronchial Foreign Bodies, Bayram Altuntaş, Yener Aydin, Ati̇la Eroğlu
Complications Of Tracheobronchial Foreign Bodies, Bayram Altuntaş, Yener Aydin, Ati̇la Eroğlu
Turkish Journal of Medical Sciences
Background/aim: Tracheobronchial foreign bodies may cause several complications in the respiratory system. We aimed to present the complications of tracheobronchial foreign bodies. Materials and methods: Between January 1990 and March 2015, 813 patients with suspected tracheobronchial foreign body aspiration were hospitalized in our department. Patients with complications related to foreign bodies in airways were included in this study. We retrospectively evaluated the records of patients according to symptoms, foreign body type, localizations, and complications. Results: A foreign body was found in 701 of 813 patients (86.2%). Complications related to foreign bodies settled in airways were seen in 96 patients (13.7%). …
The Incidence Of 18f-Fdg Pet/Ct Thyroid Incidentalomas Andthe Prevalence Of Malignancy: A Prospective Study, Mi̇ne Şencan Eren, Özhan Özdoğan, Arzu Gedi̇k, Mehmet Ceylan, Meri̇h Güray Durak, Mustafa Seçi̇l, Mehmet Ali̇ Koçdor, Abdurrahman Çömlekçi̇, Hati̇ce Durak
The Incidence Of 18f-Fdg Pet/Ct Thyroid Incidentalomas Andthe Prevalence Of Malignancy: A Prospective Study, Mi̇ne Şencan Eren, Özhan Özdoğan, Arzu Gedi̇k, Mehmet Ceylan, Meri̇h Güray Durak, Mustafa Seçi̇l, Mehmet Ali̇ Koçdor, Abdurrahman Çömlekçi̇, Hati̇ce Durak
Turkish Journal of Medical Sciences
Background/aim: To determine the prevalence of malignancy in thyroid incidentalomas (TIs) detected by fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Materials and methods: 18F-FDG PET/CT images were evaluated prospectively for the presence of thyroid uptake. The patients with a TI were evaluated by an endocrinologist according to the predefined diagnostic algorithm. The final diagnosis was obtained clinically and/or by pathology. Results: TI was detected in 4.2% of 4204 patients. A malignant thyroid nodule was diagnosed in 29% and 33% of the focal and diffuse-focal uptake groups, respectively. However, no malignancy was detected in the diffuse uptake group. The standardized …
The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane. Materials and methods: Rats were divided into five groups: Group S (sham), saline solution; Group B, bupivacaine; Group BD, bupivacaine + dexmedetomidine; Group BC, bupivacaine + clonidine; and Group BE, bupivacaine + epinephrine. For each group, 0.2 mL of local anesthetic was injected into the sciatic nerve bifurcation …
Polymorphisms In Androgen Metabolism Genes Ar, Cyp1b1, Cyp19, And Srd5a2 And Prostate Cancer Risk And Aggressiveness In Bulgarian Patients, Darina Kachakova, Atanaska Mitkova, Elenko Popov, Olga Beltcheva, Alexandrina Vlahova, Tihomir Dikov, Svetlana Christova, Vanio Mitev, Chavdar Slavov, Radka Kaneva
Polymorphisms In Androgen Metabolism Genes Ar, Cyp1b1, Cyp19, And Srd5a2 And Prostate Cancer Risk And Aggressiveness In Bulgarian Patients, Darina Kachakova, Atanaska Mitkova, Elenko Popov, Olga Beltcheva, Alexandrina Vlahova, Tihomir Dikov, Svetlana Christova, Vanio Mitev, Chavdar Slavov, Radka Kaneva
Turkish Journal of Medical Sciences
Background/aim: The aim of our study was to elucidate the role of polymorphisms in AR, CYP1B1, CYP19, and SRD5A2 genes for prostate cancer (PC) development in Bulgarian patients. Materials and methods: We genotyped 246 PC patients and 261 controls (155 with benign prostate hyperplasia and 107 healthy population controls) using direct sequencing, PCR-RFLP, SSCP, and fragment analysis. Results: The allele and genotype frequencies of most of the studied variants did not differ significantly between cases and controls. Increased frequencies of the C/C genotype and C allele of rs1056837 in CYP1B1, and genotype 7/8 of the (TTTA)n repeat polymorphism in CYP19, …
Pharmacological Blockade Of The Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus In Rats, Laxmikant S. Deshpande, Robert E. Blair, Beverly A. Huang, Kristin F. Phillips, Robert J. Delorenzo
Pharmacological Blockade Of The Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus In Rats, Laxmikant S. Deshpande, Robert E. Blair, Beverly A. Huang, Kristin F. Phillips, Robert J. Delorenzo
Neurology Publications
Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality. However, survivors of lethal OP exposure exhibit delayed neuronal injury and chronic behavioral morbidities. In this study, we investigated neuroprotective capabilities of dantrolene and carisbamate in a rat survival model of paraoxon (POX) induced status epilepticus (SE). Significant elevations in hippocampal calcium levels were observed 48-h post POX SE survival, and treatment with dantrolene (10 mg/kg, i.m.) and carisbamate (90 mg/kg, i.m.) lowered these protracted calcium elevations. POX SE induced delayed neuronal injury …
Mathematical Modeling Of Blood Coagulation, Joana L. Perdomo
Mathematical Modeling Of Blood Coagulation, Joana L. Perdomo
HMC Senior Theses
Blood coagulation is a series of biochemical reactions that take place to form a blood clot. Abnormalities in coagulation, such as under-clotting or over- clotting, can lead to significant blood loss, cardiac arrest, damage to vital organs, or even death. Thus, understanding quantitatively how blood coagulation works is important in informing clinical decisions about treating deficiencies and disorders. Quantifying blood coagulation is possible through mathematical modeling. This review presents different mathematical models that have been developed in the past 30 years to describe the biochemistry, biophysics, and clinical applications of blood coagulation research. This review includes the strengths and limitations …
Clinical Outcomes And Optical Performance Of Four Differentmultifocal Intraocular Lenses, Başak Bostanci Ceran, Tamer Takmaz, İzzet Can, Güli̇zar Demi̇rok, Betül Seher Uysal
Clinical Outcomes And Optical Performance Of Four Differentmultifocal Intraocular Lenses, Başak Bostanci Ceran, Tamer Takmaz, İzzet Can, Güli̇zar Demi̇rok, Betül Seher Uysal
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to evaluate clinical outcomes and optical performance of 4 different multifocal intraocular lenses (IOLs). Materials and methods: Ninety eyes of 51 patients who received Reviol MFM 611, Reviol MFM 625, Acri.LISA, and ReSTOR SN6AD3 multifocal IOLs after cataract surgery were retrospectively evaluated. The patients were similar in terms of age, sex, cataract hardness and axial length. The mean outcome measures were uncorrected and corrected distance visual acuity (UDVA, CDVA), distance-corrected intermediate and near visual acuity (DCIVA, DCNVA), intra or postoperative complications, and contrast sensitivity (CS) results under mesopic conditions. The mean follow …