Digital Commons Network^™

A Study On The Validity And Reliability Of The Amblyopia Andstrabismus Questionnaire (A&Sq) In Turkish, Hali̇se Çoşkun, Sevi̇nç Taştan, Emi̇ne İyi̇gün, Fati̇h Mehmet Mutlu, Osman Meli̇h Ceylan, Hali̇l İbrahi̇m Altinsoy

Turkish Journal of Medical Sciences

Background/aim: This study aims to evaluate the reliability and validity of the Amblyopia and Strabismus Questionnaire (A&SQ) that is translated into Turkish. Materials and methods: This is a methodological study. A total of 149 patients took part in the survey research between December 2012 and June 2014 in an university hospital, and 37 were retested. Cronbach's alpha coefficient was used for the questionnaire's reliability analysis. Results: Cronbach's alpha coefficients for the subscales of fear of losing the better eye, distance estimation, visual disorientation, double vision, and social contact and appearance were found to be 0.80, 0.88, 0.95, 0.80, and 0.81, …

Psychosocial Functioning In Pediatric Patients With Pectus Excavatum And Pectus Carinatum, Ali̇ye Tuğba Bahadir, Pinar Kuru, Ayli̇n Çakiroğlu, Ceyda Afacan, Mustafa Yüksel

Turkish Journal of Medical Sciences

Background/aim: Pectus excavatum and pectus carinatum are the most commonly seen anterior chest wall deformities. Recent studies reveal that minimal invasive repair of pectus deformities improves the quality of life. Our aim is to assess the psychosocial functioning and sociodemographic characteristics of pediatric patients with pectus deformities and evaluate the differences between patients operated on with minimal invasive repair techniques and nonoperated patients. Materials and methods: Thirty-two patients with pectus deformities who were operated on 6 months or more before and 31 nonoperated patients participated in the study. The Children's Depression Inventory, Piers-Harris Children's Self-Concept Scale, Capa Social Phobia Scale …

Pain, Depression Levels, Fatigue, Sleep Quality, And Quality Of Life Inelderly Patients With Rheumatoid Arthritis, İlknur Albayrak Gezer, Ayşe Balkarli, Beray Can, Si̇nan Bağçaci, Sami̇ Küçükşen, Adem Küçük

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate and determine the relationships (if any) among pain, depression levels, fatigue, sleep quality, and quality of life in patients with rheumatoid arthritis (RA) aged 65 years and over, and to compare the results with those of RA patients under 65 years of age. Materials and methods: The study included 52 patients with RA aged 65 years and over (Group 1) and 84 patients with RA under 65 years of age (Group 2). Pain, depression levels, fatigue, sleep quality, quality of life, and disease activity of all of the participants were evaluated …

The Effect Of Trimetazidine On Renal Oxidative Stress In Partialand Complete Ureteral Obstructions In A Rat Model, Sema Nur Ayyildiz, Ali̇ Ayyildiz, Erdal Benli̇, Selma Cirrik, Rüştü Cankon Germi̇yanoğlu, Tevfi̇k Noyan, Abdullah Çirakoğlu

Turkish Journal of Medical Sciences

Background/aim: Renal oxidative stress occurs in ureteral obstructions. The purpose of this study was to investigate the effect of the antioxidant and antiischemic agent trimetazidine (TMZ) on oxidative stress following ureteral obstruction. Materials and methods: Ten groups were established. Sham groups were checked as controls after 1 and 3 weeks. The other 8 groups had partial or complete ureteral obstruction while receiving or not receiving trimetazidine (TMZ) at 5 mg/kg daily and were evaluated after either 1 week or 3 weeks. Creatinine and cystatin C measurements were performed in the serum. Malondialdehyde, myeloperoxidase, catalase, and glutathione peroxidase activity were measured …

Effects Of Whole Blood Viscosity And Plasma Nox On Cardiac Function And Cerebral Blood Flow In Children With Chronic Kidney Disease, Necla Buyan, Meltem Akçaboy, Tayfun Göktaş, Serdar Kula, Bi̇jen Nazliel, Ni̇lgün Çakar, Nermi̇n Uncu, Bülent Çeli̇k, Deni̇z Erbaş

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to investigate the effects of whole blood viscosity and plasma nitric oxide on cerebral and cardiovascular risks associated with chronic kidney disease. Materials and methods: The study group consisted of 40 pediatric patients and 21 healthy control subjects. Hematologic and biochemical variables, viscosity and plasma nitric oxide levels, echocardiographic findings, and middle cerebral artery blood flow velocity were examined. Results: Viscosity values of patients were significantly lower than those of the control group. Lower values of hematocrit, total protein, and albumin and higher values of ferritin in all patient groups resulted in significantly …

Emergency Coronary Bypass Surgery In Patients Under The Influence Of Dualantiplatelet Therapy: Effects Of Tranexamic Acid And Desmopressin Acetate, Gökalp Altun, Doğuş Hemşi̇nli̇, Zerri̇n Pulathan, Ali̇ Ci̇velek

Turkish Journal of Medical Sciences

Background/aim: Bleeding in patients undergoing coronary artery bypass grafting (CABG) while using dual antiplatelet therapy (DAPT) is a cause of significant morbidity and mortality. The aim of this study is to examine the perioperative hemostatic effects of tranexamic acid (TnX-A) and desmopressin acetate (Des) in these patients. Materials and methods: This clinical study was planned in a prospective and randomized manner. Fifty-four patients were enrolled and classified into 4 different groups. They were compared in terms of various bleeding and transfusion parameters.Results: No significant differences were observed between the groups in pre/intraoperative data apart from closure times. Plasmin/α-2 antiplasmin complex …

From Dose To Response: In Vivo Nanoparticle Processing And Potential Toxicity, Uschi M. Graham, Gary Jacobs, Robert A. Yokel, Burtron H. Davis, Alan K. Dozier, M. Eileen Birch, Michael T. Tseng, Günter Oberdörster, Alison Elder, Lisa Delouise

Pharmaceutical Sciences Faculty Publications

Adverse human health impacts due to occupational and environmental exposures to manufactured nanoparticles are of concern and pose a potential threat to the continued industrial use and integration of nanomaterials into commercial products. This chapter addresses the inter-relationship between dose and response and will elucidate on how the dynamic chemical and physical transformation and breakdown of the nanoparticles at the cellular and subcellular levels can lead to the in vivo formation of new reaction products. The dose-response relationship is complicated by the continuous physicochemical transformations in the nanoparticles induced by the dynamics of the biological system, where dose, bio-processing, and …

Cardiac Chemical Exchange Saturation Transfer Mr Imaging Tracking Of Cell Survival Or Rejection In Mouse Models Of Cell Therapy, Ashley L. Pumphrey, Shaojing Ye, Zhengshi Yang, Jennifer Simkin, John C. Gensel, Ahmed Abdel-Latif, Moriel H. Vandsburger

Saha Cardiovascular Research Center Faculty Publications

Purpose:

To examine whether cardiac chemical exchange saturation transfer (CEST) imaging can be serially and noninvasively used to probe cell survival or rejection after intramyocardial implantation in mice.

Materials and Methods:

Experiments were compliant with the National Institutes of Health Guidelines on the Use of Laboratory Animals and approved by the Institutional Animal Care and Use Committee. One million C2C12 cells labeled with either europium (Eu) 10-(2-hydroxypropyl)-1,4,7-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) or saline via the hypotonic swelling technique were implanted into the anterior-lateral left ventricular wall in C57BL/6J (allogeneic model, n = 17) and C3H (syngeneic model, n = 13) mice. Imaging …

Quantification Of Trace Metals In Infant Formula Premixes Using Laser-Induced Breakdown Spectroscopy, Raquel Cama-Moncunill, Maria Piedad Casado-Gavalda, Xavier Cama-Moncunill, Maria Markiewicz-Keszycka, Yash Dixit, Patrick J. Cullen, Carl Sullivan

Articles

Infant formula is a human milk substitute generally based upon fortified cow milk components. In order to mimic the composition of breast milk, trace elements such as copper, iron and zinc are usually added in a single operation using a premix. The correct addition of premixes must be verified to ensure that the target levels in infant formulae are achieved. In this study, a laser-induced breakdown spectroscopy (LIBS) system was assessed as a fast validation tool for trace element premixes. LIBS is a promising emission spectroscopic technique for elemental analysis, which offers real-time analyses, little to no sample preparation and …

A Rational Design Of A Selective Inhibitor For Kv1.1 Channels Prevalent In Demyelinated Nerves That Improves Their Impaired Axonal Conduction, Ahmed Al-Sabi, Declan Daly, Patrick Hoefer, Gemma K. Kinsella, Charles Metais, Mark Pickering, Caroline Herron, Seshu Kumar Kaza, Kieran Nolan, J. Oliver Dolly

Articles

K+ channels containing Kv1.1 α subunits, which become prevalent at internodes in demyelinated axons, may underlie their dysfunctional conduction akin to muscle weakness in multiple sclerosis. Small inhibitors were sought with selectivity for the culpable hyper-polarizing K+ currents. Modeling of interactions with the extracellular pore in a Kv1.1-deduced structure identified diaryldi(2-pyrrolyl)methane as a suitable scaffold with optimized alkyl ammonium side chains. The resultant synthesized candidate [2,2′-((5,5′(di-p-topyldiaryldi(2-pyrrolyl)methane)bis(2,2′carbonyl)bis(azanediyl)) diethaneamine·2HCl] (8) selectively blocked Kv1.1 channels (IC50 ≈ 15 μM) recombinantly expressed in mammalian cells, induced a positive shift in the voltage dependency of K+ current activation, and slowed its kinetics. It …

The Importance Of Routine Bedside Biliary Ultrasonography In The Management Of Patients Admitted To The Emergency Department With Isolated Acute Epigastric Pain, Vermi̇ Değerli̇, Tanzer Korkmaz, Hülya Mollamehmetoğlu, Cem Ertan

Turkish Journal of Medical Sciences

Background/aim: The aim of our study was to emphasize the importance of routine bedside biliary ultrasonography (USG) for the differential diagnosis of biliary tract disorders in patients admitted with acute isolated epigastric pain. Materials and methods: Adult patients who were admitted to the emergency department with acute isolated epigastric pain were included in the study. Emergency residents (ERs) were asked whether they planned to perform biliary USG during the initial evaluation and following diagnosis/treatment (secondary evaluation) of these patients. Bedside biliary USG examinations were performed by a sonologist and a radiologist evaluated the video recordings. Results: A total of 103 …

Differences In Leptin, Ghrelin, And Glucagon-Like Peptide-1 Levelsbetween Religious Fasting And Normal Fasting, Özge Telci̇ Çaklili, Banu Başok, Gülcan Yavuz, Selcan Tülü, Banu Mesçi̇, Ayteki̇n Oğuz

Turkish Journal of Medical Sciences

Background/aim: Leptin, ghrelin, and glucagon-like peptide-1 (GLP-1) affect hunger, satiety feelings, and food intake. We hypothesized that during Ramadan, if the brain knows that the body will be hungry until sunset, there may be differences between leptin, ghrelin, and GLP-1 levels in Ramadan and non-Ramadan fasting. Materials and methods: This study had two phases. In the first phase, the participants were asked to skip the dawn meal of Ramadan (suhur), so that 12 h of fasting could be achieved. Participants ceased food intake at midnight, and at noon blood was drawn. Eight participants were selected as a subgroup. These participants …

Relationship Of Spinal Curvature, Mobility, And Low Back Pain In Womenwith And Without Urinary Incontinence, Şeyda Toprak Çelenay, Derya Özer Kaya

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the relationship of sagittal spinal curvature, mobility, and low back pain (LBP) in women with and without urinary incontinence (UI). Materials and methods: Thirty-two women with UI (incontinence group) and 41 women without UI (control group) were included in this study. The sagittal spinal curvature and mobility were assessed with a Spinal Mouse device (IDIAG, Fehraltorf, Switzerland). Urogenital symptom distress, LBP, and disability caused by LBP were assessed using the Urogenital Distress Inventory-6 (UDI-6), a visual analog scale (VAS), and the Oswestry Disability Index (ODI), respectively. Results: It was seen that the sagittal thoracic …

Effects Of Genistein On Oxidative Stress And Inflammation In Acute Pancreatitis Mice, Jumlongluk Sriko

Chulalongkorn University Theses and Dissertations (Chula ETD)

Genistein (GEN), the most abundant isoflavones in soy, has similar structure to human estradiol. It has been reported the potent properties of GEN on antioxidant and anti-inflammation. The aim of this study was to investigate the effects of GEN on oxidative stress, inflammatory, and histopathology in acute pancreatitis induced by L-arginine in mice. Male ICR mice were randomly divided into 4 groups (6 mice in each group). Control (Con) group: mice were injected with 2% dimethyl sulfoxide (DMSO) once daily for 4 days, via IP. Acute pancreatitis (AP) group: mice were injected 2 times (1 hour interval) of 350 mg/100 …

Surface Proteomics Of Leptospira Interrogans Serovar Pomona, Praparat Thaibankluay

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leptospirosis is a re-emerging zoonosis of global distribution including Thailand. It caused by pathogenic Leptospira. The pathogenesis is not clear. Surface-exposed proteins (PSEs) are first part for interactions with host cells, immune system and should be potential targets for vaccine development. To date, many researches study only individual PSEs but the studies of surface proteomic is less. The study of surface proteomic will be important information for pathogenesis studies and search for vaccine candidate. This study aimed to identify surface proteomics of pathogenic Leptospira by surface biotinylation and surface shaving using proteinase K that has been used to identify surface …

Microbiota, Diet And Medication In Human Gut Disorders, Adam Clooney

Theses

The microbiota, a community of micro-organisms in a particular environment, have been intensely researched in the past decade and interest appears to continue to increase. The human body is richly populated with bacterial cells (3.8x10'^) and alterations in these communities are associated with disease. The work presented in this thesis explores aspects of microbiota research methodologies with regard to optimisation and concerns over a lack of reproducibility. Additionally, we investigated the effects of medication, in particular Proton Pump Inhibitors, on the human gut microbiota, along with comparisons between the microbiota of patients with active and inactive Inflammatory Bowel Disease.

Microbiota …

The Effects Of The Chloride:Sodium Ratio On Acid-Base Statusand Mortality In Septic Patients, Hakan Korkut Atalan, Bülent Güçyetmez

Turkish Journal of Medical Sciences

Background/aim: Calculation of the chloride:sodium (Cl-:Na+) ratio is proposed to enable a quick evaluation of the effect of Cl- and Na+ on the acid-base balance in critically ill patients. In the present study, the relationship of the Cl-:Na+ ratio of septic patients with acidbase status and ICU mortality were investigated. Materials and methods: In our two-center study, 434 patients who were diagnosed with sepsis were included. The patients were divided into three groups: low (<0.75), normal (≥0.75, <0.80), and high (≥0.80) Cl-:Na+ ratio groups. Patients' demographic data, blood gas values, length of ICU stay, and ICU mortality were recorded. Results: In the low and high groups, ICU mortality was significantly higher than in the normal group (29.3%, 37.1%) (P = 0.005). There was a negative correlation between the Cl:Na+ ratio and each of HCO3 -, standard base excess, and PaCO2 (r2 = 0.21, r2 = 0.19, and r2 = 0.17) (P < 0.001 for each). In the multivariate analysis, the ICU mortality was increased 2.6-fold (1.2-5.8) by low Cl-:Na+ ratio (P = 0.019). Conclusion: The Cl-:Na+ ratio is a useful parameter for showing the relationship between Cl- and Na+ and their impact on acid-base status. Low Cl-:Na+ ratio at ICU admission can be used as a prognostic indicator for increased ICU mortality in septic patients.

Associations Between Obesity And The Radiographic Phenotype In Knee Osteoarthritis, Mehmet Derya Demi̇rağ, Seçi̇l Özkan, Şemi̇nur Haznedaroğlu, Evi̇n Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Goker

Turkish Journal of Medical Sciences

Background/aim: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. Materials and methods: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal. Results: Obese patients had a significantly more frequent osteophyte-dominant pattern compared to nonobese subjects (74.5% and 38%, respectively, P < 0.001). Logistic regression analysis demonstrated that obesity had a stronger association with an osteophytedominant pattern compared to a JSN-dominant pattern (OR and 95% CI = 7.16 (3.15-16.26) and 1.63 (0.96-2.78), respectively). Age had a very weak effect on the distinction to an osteophyte-dominant pattern and no effect on JSN dominance (OR and 95% CI = 1.1 (1.06-1.15) and 1.02 (0.99-1.05), respectively). Conclusion: There might be an association between obesity and the radiographic phenotype in patients with knee osteoarthritis. The findings suggest that the association between obesity and the osteophyte formation is stronger than that of JSN.

The Efficacy Of Microphototherapy With A Medlight Cupcubegrimed Device In Psoriatic Patients With Localized Lesions, Nesli̇han Yildirim, Gül Erki̇n

Turkish Journal of Medical Sciences

Background/aim: Psoriasis is a chronic skin disease. To reduce side effects associated with current treatment modalities, new treatment methods are required. Some clinicians have begun to use microphototherapy to treat psoriatic patients with a limited number of lesions (lesions affecting <10% of the body surface area). Materials and methods: Microphototherapy is indicated in patients whose lesions persist despite systemic and topical treatment or when such treatment is contraindicated. Our study aimed to evaluate the efficacy of microphototherapy in psoriasis patients with localized lesions. Patients in this unblinded and prospective study were treated three times a week for 50 sessions using a MedLight CupCUBE Grimed microphototherapy device that emits an ultraviolet B (UVB) spectrum. Results: Forty-five lesions in 23 psoriatic patients were treated. Treatment outcome was evaluated based on the Psoriasis Severity Index (PSI). PSI scores decreased significantly during the treatment. Conclusion: The MedLight CupCUBE Grimed microphototherapy device was effective for the treatment of psoriasis patients with localized lesions. The device can administer UVB radiation to involved regions while protecting uninvolved regions and minimizing radiation dose. However, having to be administered by experienced technicians and the long time required for each treatment session are disadvantages of the technique.

Antioxidants Status In Type 2 Diabetic Patients In Morocco, Rachid Eljaoudi, Naoual Elomri, Meryem Laamarti, Yahia Cherrah, Taoufik Amezyane, Driss Ghafir, Azeddine Ibrahimi

Turkish Journal of Medical Sciences

Background/aim: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes. Materials and methods: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se). Results: CRP and triglycerides were higher in the diabetic group while high-density lipoprotein levels were significantly …

A Comparison Of Usage Of The Laryngeal Mask Uniquetmin Denticulate And Edentulate Geriatric Patients, Meltem Genez, Semi̇h Küçükgüçlü, Şule Özbi̇lgi̇n, Bahar Kuvaki̇ Balkan, Tangül Beydeş, Melek Aksoy Sari

Turkish Journal of Medical Sciences

Background/aim: Mask ventilation in geriatric and edentulous patients can be ineffective or even impossible because of the shape inside the patients' cheeks. For patients for whom a mask cannot be used for long, the use of a laryngeal mask can ease the administration of anesthesia. The aim of this study was to compare the use of the laryngeal mask UniqueTM in denticulate and edentulate patients aged over 65 years. Materials and methods: This prospective study included patients according to the American Society of Anesthesiologists I-III classification, aged 65 years or more. The patients were divided into two groups: a dentulous …

The Turkish Version Of The Physical Activity Scale For Theelderly (Pase): Its Cultural Adaptation, Validation, And Reliability, Ender Ayvat, Muhammed Kilinç, Nuray Kirdi

Turkish Journal of Medical Sciences

Background/aim: This study aimed to describe the cultural adaptation of the Turkish Physical Activity Scale for the Elderly (PASE) and to examine the reliability and validity of the scale in older Turkish adults. Materials and methods: Eighty elderly people were recruited for the study. The assessments included the PASE, the International Physical Activity Questionnaire (IPAQ), the Short Physical Performance Battery and Short Form-36 Quality of Life Questionnaire (SF-36), and the Mini Mental State Test. Outcome measures were conducted twice within a week (test-retest) for reliability. Results: Cronbach's α coefficient was 0.714 for the initial evaluation. The intraclass correlation coefficient for …

Isolation Rates And Antibiotic Susceptibilities Of Different Enterobacteriaceae Species As Urinary Tract Infection Agents In Turkey: A Systematic Review, Caner Yürüyen, Yeşi̇m Gürol, Sabi̇re Ferda Kaleağasioğlu, Eli̇f Çi̇ğdem Kaspar, Gülden Yilmaz

Turkish Journal of Medical Sciences

Background/aim: In Turkey, few systematic reviews have analyzed the results of studies on the isolation rates of urinary tract infection agents and their antibiotic susceptibilities. This review was done to fill this gap and enable the correct application of guideline-based medical therapy by determining the isolation rates and antibiotic susceptibilities of different Enterobacteriaceae species in Turkey. Materials and methods: Relevant studies found from various databases with the help of previously specified search strategies were examined and eliminated according to eligibility criteria. The remaining 22 studies were included in this systematic review. Results: Escherichia coli was the most frequently isolated species …

Investigation Of The Behavioral And Neurochemical Effects Of Monosodium Glutamate On Neonatal Rats, Ayşen Çetin Kardeşler, Eyup Başkale

Turkish Journal of Medical Sciences

Background/aim: The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period. Materials and methods: In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method. Results: Considering the …

Assessment Of Repolarization Abnormalities In Baseline Electrocardiograms Of Patients With Myocarditis, Haci Murat Güneş, Gamze Babur Güler, Ekrem Güler, Gülteki̇n Günhan Demi̇r, Mehmet Kami̇l Teber, Fi̇li̇z Kizilirmak Yilmaz, Beytullah Çakal, Bi̇lal Boztosun

Turkish Journal of Medical Sciences

Background/aim: Myocarditis in the acute phase usually presents with sinus tachycardia but many other arrhythmias might be seen as well. In this study we aimed to investigate repolarization abnormalities in baseline ECG of patients with myocarditis for the first time.Materials and methods: Thirty patients diagnosed with myocarditis and 25 healthy age-matched controls were included. Two different cardiologists measured corrected QT (QTc), QT dispersion (QTd), QT peak (QTp), T wave peak to T wave end (TpTe), TpTe/QT ratio, and TpTe/QTc ratio in 12-lead ECG.Results: When compared with the control group, QTp (P: 0.021), QT (P: 0.003), TpTe (P < 0.001), TpTe/QTc ratio (P < 0.001), and TpTe/QT ratio (P: 0.005) were significantly higher in patients with myocarditis. A comparison of receiver operating characteristic (ROC) curves was conducted using the Hanley and McNeil method. The area under the curve (AUC) of the electrocardiographic characteristics QT (AUC: 0.736; 95% CI [0.600-0.846]), QTP (AUC: 0.680; 95% CI [0.540-0.799]), and TpTe (AUC: 0.771; 95% CI [0.638-873]) and TpTe/QTc (AUC: 0.774; 95% CI [0.641-0.876]) and TpTe/QT (AUC: 0.726; 95% CI [0.589-0.838]) in myocarditis were not significantly different from each other but all of them were different from 0.5.Conclusion: Baseline ECGs of patients with myocarditis were associated with repolarization abnormalities. These novel findings may be one of the reasons underlying arrhythmic events in patients with myocarditis.

Combined Oral Supplementation Of Chromium Picolinate, Docosahexaenoic Acid, And Boron Enhances Neuroprotection In Rats Fed A High-Fat Diet, Cemal Orhan, Nurhan Şahi̇n, Zeynep Tuzcu, James R. Komorowski, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD). Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW). Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the …

Morphometric Analysis Of The Foramen Magnum Using Cone Beam Computed Tomography, Gülsün Akay, Kahraman Güngör, İlkay Peker

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to perform morphometric analysis of the foramen magnum (FM) using cone-beam computed tomography (CBCT). Materials and methods: This study included CBCT images of 190 individuals (88 males and 102 females). The sagittal and transverse diameters and circumference of the FM were measured. The shape of FM was classified as round, hexagonal, oval, egg-shaped, tetragonal, pentagonal, irregular A, and irregular B. The data were statistically analyzed with chi-square and t-tests to assess the level of significance for sex and age. Results: The means of its sagittal and transverse diameters and also circumference were higher …

The Efficacy Of In Situ Local Autograft In Adolescent Idiopathic Scoliosis Surgery: A Comparison Of Three Different Grafting Methods, Meti̇n Işik, Haci Mustafa Özdemi̇r, Abdurrahman Sakaoğullari, Bertan Cengi̇z, Nevres Hürri̇yet Aydoğan

Turkish Journal of Medical Sciences

Background/aim: This study was performed to show the efficacy of in situ local autograft with a comparison of in situ local autograft, local autograft with allograft, and local autograft with posterior iliac crest autograft.Materials and methods: In this prospective randomized study, a total of 65 adolescent idiopathic scoliosis (AIS) patients were separated into 3 groups: Group 1 using local autograft and allograft, Group 2 using local autograft only, and Group 3 using local autograft and posterior iliac crest autograft. Posterior segmental instrumentation was also applied to all patients. The mean follow-up period was 28.5 months (range, 15-40 months). Pseudarthrosis was …

Evaluation Of Renal Anomalies, Inferior Vena Cava Variations, And Left Renalvein Variations By Lumbar Magnetic Resonance Imaging In 3000 Patients, Alper Di̇lli̇, Fatma Sevi̇n Coşar Ayaz, Kezi̇ban Karacan, Kürşad Zengi̇n, Ümi̇t Yaşar Ayaz, Osman Rai̇f Karabacak, Baki̇ Heki̇moğlu

Turkish Journal of Medical Sciences

Background/aim: The variations and anomalies of the kidneys besides the variations of the inferior vena cava (IVC) and left renal vein (LRV) are mostly asymptomatic, but they carry potential risks particularly during retroperitoneal surgery and radiological interventions. Our aim was to find the frequencies, types, and sex distribution of renal anomalies and variations of the IVC and LRV utilizing magnetic resonance imaging (MRI). Materials and methods: Between November 2010 and April 2011, a retrospective study was conducted including lumbar spinal MRI of 3000 consecutive patients (1869 females and 1131 males) with a median age of 54 years (range: 9-78 years). …

Effects Of N-Acetylcysteine On Ovarian Tissue Autografted Intogranulation Tissue Compared To Back Muscle In Rats, Farideh Daneshpoya, Mojtaba Karimipour, Masoumeh Zirakjavanmard, Bagher Pourheydar

Turkish Journal of Medical Sciences

Background/aim: Ovarian transplantation can preserve fertility in cancer patients. The aim of this study was to compare ovarian transplantation into granulation tissue (GT) versus back muscle (BM) sites and also to investigate the effects of N-acetylcysteine (NAC) as an antioxidant on ovarian survival in a rat autograft model.Materials and methods: Twenty-eight adult female rats were divided into four equal groups (n = 7 each) as follows: Group 1, ovarian tissue grafted into GT + saline (GT + saline); Group 2, ovarian tissue grafted into GT + NAC (GT + NAC); Group 3, ovarian tissue grafted into BM + saline (BM …