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A Scale For Assessing The Severity Of Diseases And Adverse Drug Reactions: Application To Drug Benefit And Risk, Ronald J. Tallarida, Rodney B. Murray, Carl Eiben

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Physicians were interviewed to assess their willingness to risk adverse drug reactions among patients. These untoward reactions were ranked according to severity and weighted against the primary illness being treated. A specially designed questionnaire in the form of a matrix was used. Severity was divided into seven classes denoted by progressively increasing numerical scores, W₁ to W₇, whose values could be calculated from analysis of the completed questionnaires. The questionnaires presented several cases, in each of which an illness of specified severity was to be treated with a drug whose untoward reactions differ in severity from that …

Faculty Book Publications 1956 - 1980, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 194 publications.

Interplanetary Magnetic Field Sector Polarity And Neuropsychiatric Adaption: A Reanalysis, Hans W. Wendt

Journal of the Minnesota Academy of Science

Recent Russian studies reported associations between adaptation syndromes and (solar activity-related) interplanetary magnetic field (IMF) sector polarity. Certain ambiguities in the original work suggested some reanalyses, based on the graphs and data made available. Syndrome status exhibited a biphasic (semi annual) trend. It also correlated with specific geomagnetic changes during magnetic storms and possibly after sudden impulses. Moreover, lag effects and higher order interactions were noted among all parameters investigated. The restudy tends to support some of the original findings but also suggests new conclusions regarding potential relationships between geophysical/solar and psychophysiological processes.

Role Of A Nonimmunoglobulin Cell Surface Determinant In The Activation Of B Lymphocytes By Thymus-Independent Antigens*, Subbarao Bondada, Donald E. Mosier, Aftab Ahmed, James J. Mond, Irwin Scher, William E. Paul

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Lyb 5 is a B-cell alloantigen which is expressed on 50-60% of B cells. It was defined originally on the basis of cytotoxicity. We have described a new reactivity within the anti-Lyb 5 serum on the basis of selective inhibition of antibody responses in vitro by this antiserum in the absence of complement. This inhibitory activity of anti-Lyb 5.1 serum appears to be due to recognition of antigenic determinants different from the prototype antigens detected in the cytotoxicity assay. Anti-Lyb 5 serum incorporated into spleen cell cultures selectively inhibits antibody responses to a class of thymus-independent antigens (TI-2) previously characterized …

Tritium (3h) Radiolabeling Of Protein A And Antibody To High Specific Activity: Application To Cell Surface Antigen Radioimmunoassays, Ronald L. Wilder, Catherine C. Yuen, Subbarao Bondada, Virgil L. Woods, Cornelius B. Alexander, Rose G. Mage

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Staphylococcal protein A and several different immunoglobulins have been radio-labeled to high specific activities (> 106 cpm/pg) by reductive methylation with tritiated (3H) sodium borohydride. The proteins retain excellent functional and antigenic properties. The utility of these reagents in a variety of assays for cell surface antigens is illustrated. The results indicate that this radiolabeling procedure may become the method of choice for many cell surface and solution immunoassays.

The Morphology Of The Canine Renal Lymphatic System, Kurt H. Albertine

Master's Theses

No abstract provided.

Monitoring Of Cortical Mitochondrial Respiration During Microanastomosis, George Austin, Britton Chance, William Hill, Clyde Barlow

The Dr. George M. Austin Neurology Research Collection

Monitoring of Cortical Mitochondrial Respiration During Microanastomosis. George Austin, M.D., Britton Chance, Ph.D., William Hill, M.D., Clyde Barlow, Ph.D.

Section of Neurological surgery, Loma Linda University School of medicine, Loma Linda, California, and Johnson foundation for Biophysics and Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

April 1978. 2 pg. Conference presentation

Taste-Masking: Function Of Exaggerated Prandial Drinking In Desalivate Mice, Richard C. Lewis

Journal of the Arkansas Academy of Science

Taste thresholds for the bitter compound sucrose octaacetate (SOA) were elevated by desalivation in mice. Thresholds were determined for control and experimental animals both before and after ligation of all salivary ducts. There was a significant increase in SOA thresholds in the desalivate mice, and the pre- to post-operative differences in threshold between the control and experimental groups were significant. The altered response to SOA by desalivate mice is shown to be due to the assumption of a prandial pattern of drinking as a result of desalivation. This conclusion is based on experiments with wet mash which failed to show …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Administration Documents

Papers representative of the variety of scholarly research conducted at WKU.

• Adams, Kathy. The Appalachian Language
• Barnett, Philip. A Study of Deviant Behavior of XYY Individuals in Regard to Environment and Genotype
• Bell, Brooks. Loving, Loyal Linda Loman: An Interpretive Note
• Danhauer, Janice. Motivating Workers Through Job Design
• Davis, Barbara. The Transformation of a Man into a Man of Understanding in Murinbata Society
• Davis, Diane. The Argot of the Homosexual
• Jewell, Teresa. The Life Story of the Hero of World War I - Sergeant Alvin C. York
• Lanham, Wayne. Das Knarrenschiff and a Ship of Fools: A Study in Influence …

1977 Vol. 3 No. 2, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medicinews Volume 3 Number 2 was edited and published by the staff of the School of Medicine Editorial Office.

This issue consists of 8 pages. The publication date is September 1977.

Faculty Publications 1976, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 270 publications.

Three Linked Enzyme Loci In Fishes: Implications In The Evolution Of Vertebrate Chromosomes, D C Morizot, D A Wright, M J Siciliano

Faculty, Staff and Student Publications

A three-point linkage group comprised of loci coding for adenosine deaminase (ADA), glucose-6-phosphate dehydrogenase (G6PDH), and 6-phospho-gluconate dehydrogenase (6PGD) is described in fish of the genus Xiphophorus (Poeciliidae). The alleles at loci in this group were shown to assort independently from the alleles at three other loci--isocitrate dehydrogenase 1 and 2, and glyceraldehyde-3-phosphate dehydrogenase 1. Alleles at the latter three loci also assort independently from each other. Data were obtained by observing the segregation of electrophoretically variant alleles in reciprocal backcross hybrids derived from crosses between either X. helleri guentheri or X. h. strigatus and X. maculatus. The linkage component …

Faculty Publications 1974 - 1975, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 441 publications.

Role Of Cytochrome P-450 In Methemoglobin Formation By Primaquine With Hamster Liver Microsomes, Tommy L. Hicks

Loma Linda University Electronic Theses, Dissertations & Projects

The role of cytochrome P-450 in in vitro methemoglobin formation by primaquine was investigated through a series of experiments with golden-Syrian hamsters, treated before sacrificing with phenobarbital or 20-methylcholanthrene to increase the cytochrome P-450 content or with cobaltous chloride to cause its decrease. To determine the extent of induction in the liver microsomal cytochrome P-450-dependent mixed-function oxidases, cytochrome P-450 content and formaldehyde from the 0-demethylation of p-nitroanisole were measured. A 90% increase occurred in cytochrome P-450 content with phenobarbital pretreatment and an increase of 102% was observed in p-nitroanisole 0-demethylation. Formaldehyde from primaquine increased 64%. The methylcholanthrene treatment produced a …

An Investigation Of The Activity Of Specific Antibody Isolated Using Immunoadsorbents, Guy Joseph Agostino

Master's Theses

No abstract provided.

A Batch Method For The Isolation Of Immunogenically Pure Igg, Iga, And Igm From Human Sera, Samuel Christopher Powell

Chemistry & Biochemistry Theses & Dissertations

A method is described for preparing an enriched fraction of the three major antibodies, immunoglobulins IgG, IgA and IgM, from normal human serum by a batch method. Selective precipitation of these proteins was carried out in successive steps using polyethylene glycol (PEG) of average molecular weight 6,000 at concentrations of 7%, 12% and 14% (16) . Zinc sulfate (10 mM) was used to remove highly immunogenic alpha₂ macroglobulin from the IgM fraction. IgA, IgM and IgG were further purified by adsorption methods using DEAE-cellulose. Quantitation and qualitation of the enriched fractions showed nearly complete separation of each of the …

Chemicals And Food: An Account About Additives, Wayland E. Noland

Journal of the Minnesota Academy of Science

Food additives are listed by functional category and discussed in terms of the scale of their use and relative risks in terms of long-term human toxicity. The greatest risks appear to lie with the antimicrobial preservative agents, and food colors (which serve only a cosmetic purpose); these and the synthetic sweeteners are discussed in relatively greater detail.

Chlorofluorocarbon Effects On Cardiac, Pulmonary, And Respiratory Patients, Mildred E. Olson

Journal of the Minnesota Academy of Science

Research results from studies of the physiological effects of aerosal propellants on animals and people are summarized. The papers selected for this summary were published between 1968 and 1975. Effects of the 15 chlorofluorocarbons used as propellants have been recorded on the cardiac, pulmonary and respiratory functions of a number of animal species as well as man. The fifteen propellants have been classified into four groups on the basis of their degree of toxicity. Fluorocarbon 11, the most frequently used propellant, is in group 1, the most toxic. The relative toxicity of each of the 14 other propellants compared with …

Measurement Of Permeability Of The Cell Membrane To Water, Richard Moore, Frederick Thornburgh, Donggyu Jin

Journal of the Minnesota Academy of Science

The water permeability was measured for blood cells from normal subjects and for blood cells from patients with leukemia. The method of measurement of the kinetics of water influx employed a stopped flow apparatus. The method of calculation of results was based on irreversible thermodynamics. The measurements and calculations were both performed with the assistance of a computer. The water permeability of the leukemic cells was decreased from normal, and the values were more variable than normal. Leukemia changes the structure of the cell membrane.

The Histochemical Distribution Of Placental Calcium And Alkaline Phosphatase Activity Following Fetoplacental Dissociation In The Albino Rat, Eric Sigmond

Master's Theses

No abstract provided.

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

Lethatlity Of And Elicitation Of Protective Antibody By Vibrio Parahaemolyticus Attc 17803, Richard Carlucci

Masters Theses & Specialist Projects

The LD₅₀ of Vibrio parahaemolyticus ATCC 17803 for 13- to 18-g male mice, strain ICR, as determined by the 50% endpoint method, was found to be an estimated 7 x 10⁷ CFU, when administered intraperitoneally in 0.5 ml of 24-h broth culture, O. D. 0.5 at 650 nm, diluted to 10^-0.72.

The elicitation of protective antibody by this bacterium in male New Zealand White rabbits was demonstrated by testing control, baseline, and hyperimmune rabbit sera for their protective effect against 2 LD₅₀ of the bacterium administered intraperitoneally in 13- to 18-g male mice, strain ICR. …

An Evaluation Of The Cytotoxicity Of Root Canal Filling Materials On Tissue Culture Cells In Vitro: Grossman's Sealer, N2 Permanent, Rickert's Sealer, And Cavit, Donald D. Antrim

Loma Linda University Electronic Theses, Dissertations & Projects

An in vitro study using radioactively-labeled tissue culture cells was conducted over a seven-month period on Grossman's sealer, Rickert's sealer, N₂ Permanent, and Cavit to determine the lasting and relative tissue toxicity of these materials.

From this study it was observed that all materials possess lasting tissue toxicity. When relative toxicity is considered, Grossman's is the most toxic, followed by N₂, Rickert's and Cavit in descending order of toxicity. Both Grossman's and N₂ would be considered highly toxic, with Rickert's displaying moderate toxicity. Cavit would be considered mild to moderate in toxicity.

The use of radioactively-labeled …

The Relationship Of Alcohol Consumption In Rats To Morphine And Codeine Intake And The Metabolism Of Dopamine, Hsiu Fen Liu

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of morphine and codeine free-choice alcohol consumption in male Sprague-Dawley rats were studied. Intakes of a 10% alcohol solution in milliliters per 100 gm. of body weight were on recorded weekly. No difference was found in the alcohol intake of rats given either a morphine-supplemented diet (0.01% of the diet) or daily injection of morphine sulfate (2 mg./kg.); however, there was a significant lower intake of water (p < .05) in those rats fed the diet with morphine. Total fluid consumption of both groups given the morphine-supplemented diet and daily injection of morphine sulfate was decreased (p < .05). It was found that morphine did not affect the percentage of total fluid consumed as alcohol or the weight gain.

Two levels of codeine phosphate (10 mg./kg. and 20 mg./kg.) were injected subcutaneously into rats twice a day. It was observed that the codeine significantly decreased alcohol intake in rats …

The Effect Of Diet On Neutrophilic Phagocytosis, Linda L. Hoover

Loma Linda University Electronic Theses, Dissertations & Projects

Two series of experiments were conducted in order to determine the effects of diet on neutrophilic phagocytosis. The first series was designed to determine the effects of varying amounts of oral glucose on phagocytosis. Blood samples from 6 to 8 subjects were drawn at fasting, and at various time periods following ingestion of 12.5, 25, 50, 75, and 100 grams of glucose. In the second series of experiments, blood samples were taken from 11 subjects after an overnight fast and 2 hours following ingestion of one of 4 different liquid diets, which included the following: the meal (I), consisting of …

Pneumotachograph, Louis Diamond, William T. Lipscomb

Pharmacology and Nutritional Sciences Faculty Patents

A pneumotachograph suitable for measuring flow rates of respiratory gases in small animals and comprising essentially a flow-resisting element which can be placed in series with a subject''s airway. The pressure drop across the resistive element is proportional to the rate of airflow and is linear over the range of flows which one normally would expect to encounter in small animals (0-2 liters/min.).

Evidence For Bone Marrow Cell Attrition As A Mechanism For Granulocyte Regulation In The Canine, Vincent Dee Smith

Theses and Dissertations (ETD)

No abstract provided.

Partial Purification And Properties Of Nicotinamide Adenine Dinucleotide Phosphate-Specific Isocitrate Dehydorgenase Of Phycomyces Blakesleeanus, Adrienne Shanler

Masters Theses & Specialist Projects

none

Value Of Oxygen With Innovar And Methohexital For Outpatient Oral Surgery, Andrew D. Harsany

Loma Linda University Electronic Theses, Dissertations & Projects

This paper demonstrates the value of oxygen in maintaining arterial blood gas in an adequate range during outpatient oral surgery. Dental extractions were completed on ten patients under an anesthetic technique utilizing Innovar and methohexital with supplemental nasal oxygen. Blood gas samples were drawn at five stages during the procedure.

The mean of the PaO₂ samples drawn with the patient at the point of deepest sedation was approximately three times the normal value.

Oxygen for pulmonary ventilation provides a reservoir in the lungs, saturation of hemoglobin, and increased oxygen in the plasma which provides a margin of safety if …

The Effect Of Glucose On The Food Intake Of Goldthioglucose Injected Mice, Janet Lahti

Dissertations and Theses

Jean Mayer has postulated the presence of glucoreceptors located primarily in the ventromedial hypothalamic nuclei of the brain which are activated by glucose in the measure that they utilize it. According to Mayer, hunger occurs when glucose is not available for metabolic purposes and satiation supervenes when glucose is made available. Control of this mechanism rests with the glucoreceptors. These receptors are believed to be destroyed when an injection of the compound goldthioglucose is given to mice. These animals subsequently become obese and are found to have gold deposits and lesions in the ventromedial area and also in other parts …