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Visual Learning And Discrimination Of Abstract Visual Shapes By Crayfish, Matthew J. Boeve, Daniel A. Bergman Jan 2010

Visual Learning And Discrimination Of Abstract Visual Shapes By Crayfish, Matthew J. Boeve, Daniel A. Bergman

Student Summer Scholars Manuscripts

In nature, animals commonly experience multiple combinations of stimuli at various points in time. When two or more seemingly unrelated stimuli are detected at the same time using different sensory systems, there is the potential for an association to form between the stimuli. The animal may learn and show a response originally associated with one stimulus when it now detects the second stimulus. These stimuli are the unconditioned and conditioned stimulus of classical and operant conditioning. Many species of animals are known to learn via operant conditioning and a variety of responses can become associated with formerly neutral stimuli. Crayfish …

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Patterned Cell Cultures For High Throughput Studies Of Cell Electrophysiology And Drug Screening Applications, Anupama Natarajan Jan 2010

Patterned Cell Cultures For High Throughput Studies Of Cell Electrophysiology And Drug Screening Applications, Anupama Natarajan

Electronic Theses and Dissertations

Over the last decade, the field of tissue and bio-engineering has seen an increase in the development of in vitro high-throughput hybrid systems that can be used to understand cell function and behavior at the cellular and tissue levels. These tools would have a wide array of applications including for implants, drug discovery, and toxicology, as well as for studying cell developmental behavior and as disease models. Currently, there are a limited number of efficient, functional drug screening assays in the pharmacology industry and studies of cell-surface interactions are complicated and invasive. Most cell physiology studies are performed using conventional …

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Studies On A Novel Human Cardiospecific Transcription Factor And Its Involvement In Omi/Htra2 Mediated Cell Death, Meenakshi Puthucode Balakrishnan Jan 2010

Studies On A Novel Human Cardiospecific Transcription Factor And Its Involvement In Omi/Htra2 Mediated Cell Death, Meenakshi Puthucode Balakrishnan

Electronic Theses and Dissertations

Omi/HtrA2 is a mitochondrial serine protease that is known to translocate to the cytoplasm upon induction of apoptosis and to activate caspase-dependent and caspase-independent cell death. The molecular mechanism of Omi/HtrA2's function is not clear but involves degradation of specific substrates. These substrates include cytoplasmic, mitochondrial, as well as nuclear proteins. We have isolated a new Omi/HtrA2 interactor, the THAP5 protein. THAP5 is a fifth member of a large family of transcription factors that are involved in cell proliferation, apoptosis, cell cycle control, chromosome segregation, chromatin modification and transcriptional regulation. THAP5 is an approximately 50kDa nuclear protein, with a restricted …

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Can [F-18] Fluorodeoxyglucose Positron Emission Tomography Replace Sentinel Lymph Node Biopsy For The Detection Of Axillary Metastases In Patients With Early-Stage Breast Cancer?*, Semi̇h Görgülü, Mehmet Fati̇h Can, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Erkan Öztürk, Emel Öztürk, Müjdat Balkan, Turgut Tufan Jan 2010

Can [F-18] Fluorodeoxyglucose Positron Emission Tomography Replace Sentinel Lymph Node Biopsy For The Detection Of Axillary Metastases In Patients With Early-Stage Breast Cancer?*, Semi̇h Görgülü, Mehmet Fati̇h Can, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Erkan Öztürk, Emel Öztürk, Müjdat Balkan, Turgut Tufan

Turkish Journal of Medical Sciences

To investigate the value of fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting axillary involvement, and to compare its accuracy with sentinel lymph node biopsy (SLNB) in patients with clinically early-stage breast cancer. Materials and methods: Twenty-eight female patients with histologically-confirmed T1-2 breast cancer who were scheduled to have SLNB were included in the study. FDG-PET images were obtained 1-7 days prior to surgery with an intravenous injection of 370 MBq of FDG, while plasma glucose levels were maintained below 120 mg/dL. All the images were interpreted by 2 independent nuclear medicine specialists, who were blinded to the histological diagnoses. SLNB …

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Suitable Empiric Antibiotic Therapy Saves Life In Nosocomial Pneumonia Caused By Stenotrophomonas Maltophilia, Gürdal Yilmaz, Savaş Özsu, İfti̇har Köksal, Tevfi̇k Özlü Jan 2010

Suitable Empiric Antibiotic Therapy Saves Life In Nosocomial Pneumonia Caused By Stenotrophomonas Maltophilia, Gürdal Yilmaz, Savaş Özsu, İfti̇har Köksal, Tevfi̇k Özlü

Turkish Journal of Medical Sciences

Stenotrophomonas maltophilia is a nosocomial pathogen of increasing importance. Empiric antibiotic therapy for S. maltophilia infection is difficult because the microorganism is resistant to a number of agents typically used for health care associated infections, thus potentially increasing mortality. This study investigates 23 nosocomial pneumonia cases caused by S. maltophilia, the antibacterial sensitivity of the bacterium and the effect on mortality of suitable empiric therapy. Materials and methods: Twenty-three patients with nosocomial pneumonia caused by S. maltophilia between January 2000 and December 2006 at the Karadeniz Technical University Hospital were retrospectively investigated. Results: Suitable empiric therapy was used with 12 …

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Nitric Oxide And Trace Metals In Relation To Haemoglobin F Concentration In Nigerian Sickle Cell Disease Patients, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola Jan 2010

Nitric Oxide And Trace Metals In Relation To Haemoglobin F Concentration In Nigerian Sickle Cell Disease Patients, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola

Turkish Journal of Medical Sciences

Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a central role in the regulation of vascular homeostasis by releasing nitric oxide (NO) among other factors. Therefore, the objective of this study was to measure plasma levels of NO, trace metals, and HbF in SCD patients. Materials and methods: Plasma levels of NO, Zn, Mg, Mn, Se, Cu, Fe, Haemoglobin F (HbF) were measured in 59 steady state SCD patients referred to the Department of Haematology, University College Hospital, Ibadan, Nigeria and 35 age/sex …

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Cancer And Ovarian Tissue Cryopreservation, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer Jan 2010

Cancer And Ovarian Tissue Cryopreservation, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer

Turkish Journal of Medical Sciences

Although ovarian tissue cryopreservation is still accepted as an experimental procedure, it has recently become an increasingly resorted technique in highly specialized in vitro fertilization (IVF) clinics. Its indications include many childhood cancers, breast cancer, some autoimmune diseases, hematopoietic stem cell transplantation, and pelvic radiation therapy due to solid tumors. The chemotherapeutics and radiation therapy may diminish ovarian reserve and cause premature ovarian failure. It currently seems as the only option for fertility preservation in children where ovulation induction is ethically not acceptable, and for those when cytotoxic therapy is urgent. There are 2 main methods for transplantation of frozen-thawed …

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Serum Nitric Oxide And Peroxynitrite Levels In Adult Sero-Positive Rheumatoid Arthritis Treated With Disease Modifying Antirheumatic Drugs: A Preliminary Report, Marwan S.M. Al-Nimer, Samir Abdul-Hassan Al-Obaidi, Khalid S. Al-Dulaimi Jan 2010

Serum Nitric Oxide And Peroxynitrite Levels In Adult Sero-Positive Rheumatoid Arthritis Treated With Disease Modifying Antirheumatic Drugs: A Preliminary Report, Marwan S.M. Al-Nimer, Samir Abdul-Hassan Al-Obaidi, Khalid S. Al-Dulaimi

Turkish Journal of Medical Sciences

The contribution of inducible nitric oxide synthase (iNOS) to oxidative/nitrative stress is well documented in inflamed joints. Nitric oxide stimulates the synthesis of proinflammatory mediators and cytotoxic molecules with a pivotal role in apoptosis at the joint of rheumatoid arthritis. This study aimed to assess the serum levels of nitric oxide and peroxynitrite in sero positive rheumatoid patients treated with disease modifying antirheumatic drugs. Materials and methods: Sixteen known patients with sero-positive rheumatoid arthritis fulfilling the criteria of the American College of Rheumatology and on disease modifying antirheumatic drugs were allocated from the consultant clinic of rheumatology at Al-Yarmouk Teaching …

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Histopathologic Changes In The Rabbit Submandibular Gland After 5-Fluorouracil Chemotherapy, Oktay Özel, Abdullah Ayçi̇çek, Fethullah Kenar, Fatma Aktepe, Ramazan Sargin, Mustafa Deni̇z Yilmaz, Fevzi̇ Sefa Dereköy Jan 2010

Histopathologic Changes In The Rabbit Submandibular Gland After 5-Fluorouracil Chemotherapy, Oktay Özel, Abdullah Ayçi̇çek, Fethullah Kenar, Fatma Aktepe, Ramazan Sargin, Mustafa Deni̇z Yilmaz, Fevzi̇ Sefa Dereköy

Turkish Journal of Medical Sciences

To determine the early-stage effects of 5-fluorouracil (5-FU) on the histology of the submandibular gland. Materials and methods: The study included 30 New Zealand rabbits. They were divided into 3 groups. No drugs were administered to group 1 (control group), and 5-FU was administered for 5 days to group 2 and for 10 days to group 3. Submandibular gland excision was then performed. Histopathological examination was performed with hematoxylin-eosin staining, apoptosis was determined based on TUNEL staining, and cell proliferation was examined using the PCNA antibody. Results: While no granular change was seen in group 1, granular change was observed …

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Comparison Of The Effects Of Repeated Dose Treatments Of Lornoxicam And Meloxicam On Renal Functions In Rats, Başak Pehli̇van, Özgün Çuvaş, Hülya Başar, Fati̇h Bakir, Hüseyi̇n Üstün, Bayazit Di̇kmen Jan 2010

Comparison Of The Effects Of Repeated Dose Treatments Of Lornoxicam And Meloxicam On Renal Functions In Rats, Başak Pehli̇van, Özgün Çuvaş, Hülya Başar, Fati̇h Bakir, Hüseyi̇n Üstün, Bayazit Di̇kmen

Turkish Journal of Medical Sciences

We aimed to investigate the renal effects of meloxicam, a preferential cyclooxygenase-2 inhibitor nonsteroidal antiiflammatory drug, and lornoxicam, a nonspecific cyclooxygenase inhibitor, in rats. We wanted to test the hypothesis that preferential cyclooxygenase-2 inhibitors have a higher renal safety profile when compared with the nonspecific cyclooxygenase inhibitors. Materials and methods: Thirty healthy male Sprague-Dawley rats were included in the study. During the study period, 0.9% NaCl, 5.8 mg kg^{-1} meloxicam, or 1.3 mg kg^{-1} lornoxicam were given in 1 mL volumes once daily by the peritoneal route. On day 14, rats were placed in metabolic cages and their urine was …

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Protective Effect Of Selenium On Intussusception-Induced Ischemia/Reperfusion Intestinal Oxidative Injury In Rats*, Hülya Akman, Sali̇h Somuncu, Günnur Di̇kmen, Şebnem Ayva, Tutku Soyer, Paki̇ze Doğan, Murat Çakmak Jan 2010

Protective Effect Of Selenium On Intussusception-Induced Ischemia/Reperfusion Intestinal Oxidative Injury In Rats*, Hülya Akman, Sali̇h Somuncu, Günnur Di̇kmen, Şebnem Ayva, Tutku Soyer, Paki̇ze Doğan, Murat Çakmak

Turkish Journal of Medical Sciences

To evaluate the protective effect of selenium on intestinal ischemia-reperfusion injury due to intussusception. Materials and methods: Forty Wistar albino rats were allocated to 4 equal groups (n = 10). After anesthetization, 2 cm of intestinal segment, 20 cm proximal to the ileocecal valve, was removed in the control group (CG). In the intussusception group (ING), intussusception was performed 20 cm proximal to the ileocecal valve by pushing the proximal intestinal segment distally with a stylet, and 2 cm of intestinal segment was removed 4 h later. Intussusception was reduced and a 2 cm segment was removed after another 4 …

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Possible Role Of Toxoplasmosis In Patients With First-Episode Schizophrenia*, Mehmet Tanyüksel, Özcan Uzun, Engi̇n Araz, Özgür Koru, Cahi̇t Babür Jan 2010

Possible Role Of Toxoplasmosis In Patients With First-Episode Schizophrenia*, Mehmet Tanyüksel, Özcan Uzun, Engi̇n Araz, Özgür Koru, Cahi̇t Babür

Turkish Journal of Medical Sciences

To determine the possible relationship between toxoplasmosis and patients with first-episode schizophrenia (FES). Materials and methods: Seventy-three subjects with FES (15-54 years old; mean: 23.4 years) and 40 healthy individuals (20-54 years old; mean: 30.3 years) were enrolled in the study. Most of the FES patients (90.4%) and the control individuals (95.0%) were male. Specific IgG and IgM antibodies to Toxoplasma gondii were investigated by enzyme-linked immunosorbent assay (ELISA), and the total amount of antibodies was investigated with the Sabin-Feldman dye test (SFDT). Results: Compared to the control individuals, study subjects had significantly more toxoplasmosis-like symptoms and more cats in …

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Are Serum Aluminum Levels A Risk Factor In The Appearance Of Spontaneous Pneumothorax?, Serdar Han, Rasi̇h Yazkan, Bülent Koçer, Gülteki̇n Gülbahar, Serdal Kenan Köse, Koray Dural, Ünal Sakinci Jan 2010

Are Serum Aluminum Levels A Risk Factor In The Appearance Of Spontaneous Pneumothorax?, Serdar Han, Rasi̇h Yazkan, Bülent Koçer, Gülteki̇n Gülbahar, Serdal Kenan Köse, Koray Dural, Ünal Sakinci

Turkish Journal of Medical Sciences

To investigate the relationship between aluminum and spontaneous pneumothorax (SP) development. Materials and methods: A patient group and a control group were formed with 100 individuals in each. The serum aluminum levels of the groups were determined and statistically compared. Results: The mean serum aluminum levels were 5.6 ± 2.4 \mug/L (1.6-11.9) and 23.2 ± 15.4 \mug/L (2-81) in the control and SP groups, respectively (P < 0.001). The specificity and sensitivity of the measurement of aluminum level were 74.4% and 86.4% in the SP group. The risk of SP development was found to be 18 times higher in individuals with high serum levels of aluminum compared to that in individuals with low serum levels of aluminum. Conclusion: A high level of aluminum is a risk factor for the development of SP.

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Does Melatonin Alleviate Cold Preservation Injury Of The Liver?, Ömer Günal, Abdurrahman Coşkun, Ari̇f Aslaner, Ümran Yildirim Jan 2010

Does Melatonin Alleviate Cold Preservation Injury Of The Liver?, Ömer Günal, Abdurrahman Coşkun, Ari̇f Aslaner, Ümran Yildirim

Turkish Journal of Medical Sciences

To investigate the effect of melatonin added to preservation solution on liver cold ischemia. Materials and methods: Twenty male Wistar albino rats were divided equally into groups treated with University of Wisconsin (UW) solution with and without melatonin. The LDH, AST, and ACP activities of the preservation solutions were determined in samples collected at 2, 24, 36, and 48 h. Tissue malondialdehyde and heat shock protein (HSP 70) levels were also measured and a histological examination was performed at 48 h. Results: Melatonin prevented enzyme elevation, induced heat shock protein (HSP 70), and decreased lipid peroxidation effectively in comparison to …

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Effect Of Essential Hypertension On Qtc Dispersion In Patients With Intracerebral Haemorrhage, Dursun Aygün, Bülent Şi̇şman, Mehmet Seli̇m Nural, Özcan Yilmaz, Ahmet Baydin Jan 2010

Effect Of Essential Hypertension On Qtc Dispersion In Patients With Intracerebral Haemorrhage, Dursun Aygün, Bülent Şi̇şman, Mehmet Seli̇m Nural, Özcan Yilmaz, Ahmet Baydin

Turkish Journal of Medical Sciences

To investigate the effects of essential hypertension on QTc dispersion (QTcd) in patients with intracerebral haematoma (ICH). Materials and methods: This prospective study included adult patients presenting with acute ICH within the first 24 h of ictus to the Emergency Department (ED). On admission, following the first clinical assessment of patients, a complete 12-lead ECG and non-contrast computed tomography (CT) were obtained from each patient. Then, the patients were divided into 2 subgroups according to the presence of hypertension history. The patient groups were compared to each other as well as the control group for QTcd. Results: The study groups …

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The Effect Of Microorganisms On Cytokine Secretion From Bone Marrow Dendritic Cells, Işil Fi̇dan, Ayşe Kalkanci, Emi̇ne Yeşi̇lyurt, Berna Erdal, Semra Kuşti̇mur, Turgut İmi̇r Jan 2010

The Effect Of Microorganisms On Cytokine Secretion From Bone Marrow Dendritic Cells, Işil Fi̇dan, Ayşe Kalkanci, Emi̇ne Yeşi̇lyurt, Berna Erdal, Semra Kuşti̇mur, Turgut İmi̇r

Turkish Journal of Medical Sciences

Dendritic cells (DCs) are potent antigen-presenting cells crucial for initiation of cell-mediated immune responses to foreign antigens. They also contribute to the innate resistance against microbial pathogens. The present study examined the effect of microorganisms such as Escherichia coli (E. coli), Serratia marcescens (S. marcescens), Methicillin-resistant Staphylococcus aureus (MRSA), coagulase negative staphylococci (CoNS), and Candida albicans (C. albicans) on cytokine secretion in bone marrow-dendritic cells (BM-DCs). Materials and methods: The levels of cytokines in culture supernatants of the BM-DC were determined by enzyme-linked immunosorbent assay. Results: DCs stimulated by microorganisms produced large amounts of TNF-\alpha, IL-1\beta, IL-6, and IL-10. The …

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Comparative Efficacy Of Caffeic Acid Phenethyl Ester (Cape), Olopatadine Hydrochloride, And Dexamethasone Sodium Phosphate In Experimental Allergic Conjunctivitis*, Erdi̇nç Aydin, Heli̇n Deni̇z Demi̇r, Hüseyi̇n Özyurt, Ünal Erkorkmaz Jan 2010

Comparative Efficacy Of Caffeic Acid Phenethyl Ester (Cape), Olopatadine Hydrochloride, And Dexamethasone Sodium Phosphate In Experimental Allergic Conjunctivitis*, Erdi̇nç Aydin, Heli̇n Deni̇z Demi̇r, Hüseyi̇n Özyurt, Ünal Erkorkmaz

Turkish Journal of Medical Sciences

To compare the antiallergic efficacy of 1% caffeic acid phenethyl ester (CAPE), 0.1% olopatadine hydrochloride, and 0.1% dexamethasone sodium phosphate. Materials and methods: Experimental allergic conjunctivitis was provoked by a mast cell activator (compound 48/80) in 31 New Zealand rabbits. The rabbits were divided into 3 groups, and 1% CAPE, 0.1% olopatadine hydrochloride, and 0.1% dexamethasone sodium phosphate were instilled 30 min before and 15 min after the provocation. The edema and hyperemia in the experimental (right) eyes and control (left) eyes were scored in each group. Anterior segment photographs and conjunctival samples for histopathological evaluation and scoring were taken. …

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Histopathological Effects Of Chronic Fluorosis On The Liver Of Mice (Swiss Albino), Yusuf Ersan, Evren Koç, İsmai̇l Ari, Başaran Karademi̇r Jan 2010

Histopathological Effects Of Chronic Fluorosis On The Liver Of Mice (Swiss Albino), Yusuf Ersan, Evren Koç, İsmai̇l Ari, Başaran Karademi̇r

Turkish Journal of Medical Sciences

Fluoride intake in high doses has toxic effects on various organs. Chronic fluorosis results in tubular degenerations, inflammation, fibrosis, parenchymatous nephritis, cloudy swellings, and dilations of convoluted tubules. In addition to these effects, fluoride causes deteriorative effects on the skeleton, teeth, and soft tissues. The goal of this study was to examine the impacts of chronic fluorosis on the liver tissues of mice. Materials and methods: One control group and 3 experimental groups, each group consisting of 4 male and 4 female mice, were formed to conduct the experiment. A stock solution including 2000 ppm fluoride was prepared by solving …

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Effects Of Alendronate And Risedronate Therapy On Hepatic Antioxidant Enzyme Activity And Lipid Peroxidation In Ovariectomized Rats, Serap Yalin, Ülkü Çömelekoğlu, Selda Bağiş, Mehmet Berköz, Peli̇n Eroğlu Jan 2010

Effects Of Alendronate And Risedronate Therapy On Hepatic Antioxidant Enzyme Activity And Lipid Peroxidation In Ovariectomized Rats, Serap Yalin, Ülkü Çömelekoğlu, Selda Bağiş, Mehmet Berköz, Peli̇n Eroğlu

Turkish Journal of Medical Sciences

To evaluate the effects of alendronate (ALN) and risedronate (RIS), which are agents for preventing and treating postmenopausal osteoporosis, on hepatic antioxidant enzyme activity and lipid peroxidation in ovariectomized rats. Materials and methods: Thirty-two female rats were randomly assigned to 4 separate groups. All of the groups, except the control group, were ovariectomized. Included in the 4 groups were a control group (C), an ovariectomized group (OVX), an ovariectomized group treated with alendronate (OVX-ALN), and an ovariectomized group treated with risedronate (OVX-RIS). Ten weeks after an ovariectomy, the OVX-ALN rats were administered 1.75 mg/kg of their body weight with alendronate …

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Pulmonary Hydatid Disease In Southeastern Anatolia, Turkey, Selver Özeki̇nci̇, Şule Bakir, Ali̇ Kemal Uzunlar, Şevval Eren Jan 2010

Pulmonary Hydatid Disease In Southeastern Anatolia, Turkey, Selver Özeki̇nci̇, Şule Bakir, Ali̇ Kemal Uzunlar, Şevval Eren

Turkish Journal of Medical Sciences

To evaluate retrospectively epidemiological parameters and clinicopathologic figures of pulmonary hydatid disease in our region. Materials and methods: A total of 117 cases of human pulmonary hydatid disease were included in this study, and these cases were diagnosed in the Department of Pathology of Dicle University Medical School, between 1987 and 2007. The patients' data were retrospectively collected from archival reports; in addition, some of the patients were still alive and contactable. Results: Our 117 cases consisted of 66 (56.41%) females and 51 (43.58%) males. The average age was 28.18. Pulmonary hydatidosis appears to be more common in younger individuals. …

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Effects Of Vitamin A And C And Melatonin On 3-Nitrotyrosine Formation In Guinea Pig Heart Under Lipopolysaccharide-Induced Stress, Hali̇l Yaman, Tuncer Çayci, Meli̇k Seyrek, Emi̇n Özgür Akgül, Yasemi̇n Gülcan Kurt, İbrahi̇m Aydin, Hakan Yaren, Erdi̇nç Çakir, Ömer Özcan, Behzat Çi̇men, Nurten Türközkan, Mehmet Kemal Erbi̇l Jan 2010

Effects Of Vitamin A And C And Melatonin On 3-Nitrotyrosine Formation In Guinea Pig Heart Under Lipopolysaccharide-Induced Stress, Hali̇l Yaman, Tuncer Çayci, Meli̇k Seyrek, Emi̇n Özgür Akgül, Yasemi̇n Gülcan Kurt, İbrahi̇m Aydin, Hakan Yaren, Erdi̇nç Çakir, Ömer Özcan, Behzat Çi̇men, Nurten Türközkan, Mehmet Kemal Erbi̇l

Turkish Journal of Medical Sciences

Bacterial lipopolysaccharide (LPS) triggers synthesis of nitric oxide (NO) and superoxide (O_2^{.-}). O_2^{.-} can react with NO to produce the powerful oxidant peroxynitrite (ONOO-). The presence of 3-nitrotyrosine (3-NT) in tissues is often used as a marker of ONOO- production. Vitamin A, vitamin C, and melatonin are potent antioxidant molecules. We sought to clarify this issue by examining the effects of vitamin A (15,000 IU/kg/day), vitamin C (600 mg/kg/day), and melatonin (25 mg/kg) on 3-NT formation in heart tissue in a guinea pig model of LPS-induced endotoxemia. Materials and methods: A total of 75 animals were randomly divided into 5 …

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Dissection Of Mesoappendix In Laparoscopic Appendectomy: A Comparison Of Monopolar Cautery And Bipolar Vessel Sealing System, Emrah Şenel, Fati̇h Akbiyik, Hali̇l Faruk Atayurt, Hüseyi̇n Tuğrul Ti̇ryaki̇ Jan 2010

Dissection Of Mesoappendix In Laparoscopic Appendectomy: A Comparison Of Monopolar Cautery And Bipolar Vessel Sealing System, Emrah Şenel, Fati̇h Akbiyik, Hali̇l Faruk Atayurt, Hüseyi̇n Tuğrul Ti̇ryaki̇

Turkish Journal of Medical Sciences

Various technique and different instruments like endoscopic stapler, endoscopic clip, monopolar cautery, harmonic scalpel, and bipolar vessel sealer can be used in the dissection of appendix mesentery when performing laparoscopic appendectomy. The aim of this study is to evaluate the effects of using monopolar cautery and bipolar vascular sealing instruments in the dissection of mesentery of appendix on the duration of the operation of pediatric patients. Materials and methods: Sixty three patients, operated laparoscopically for acute appendicitis in between June 2008 and June 2009 at the Pediatric Surgery Clinic of Dışkapı Children's Hospital, are evaluated retrospectively. Monopolar cautery was used …

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Comparative Effects Of Levosimendan And Dobutamine Infusion On P Wave Dispersion In Patients With Acute Decompensated Heart Failure, Ati̇la İyi̇soy, Turgay Çeli̇k, Murat Çeli̇k, Bariş Buğan, Hali̇l Yaman Jan 2010

Comparative Effects Of Levosimendan And Dobutamine Infusion On P Wave Dispersion In Patients With Acute Decompensated Heart Failure, Ati̇la İyi̇soy, Turgay Çeli̇k, Murat Çeli̇k, Bariş Buğan, Hali̇l Yaman

Turkish Journal of Medical Sciences

We aimed to evaluate the comparative effects of levosimendan and dobutamine on P-wave dispersion (PWD) in the patients with acute decompensated heart failure (ADHF). Materials and methods: The study population consisted of 40 patients (mean age = 68 years, 23 men, NYHA class III-IV) presented with ADHF. Patients were randomized to intravenous levosimendan (n = 20) or dobutamine (n = 20) groups. The P-wave duration measurements were calculated in 12-lead surface ECG simultaneously and recorded before and after treatment. Manual measurements of P-wave duration were performed with digital calipers on a high resolution computer screen by two cardiologists not aware …

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Vitamin C Modulates Oxidative Stress-Induced Colitis In Rats, Mustafa Zeri̇n, Ali̇ Zi̇ya Karakilçik, Muharrem Bi̇ti̇ren, Davut Musa, Abdullah Özgönül, Şehabetti̇n Selek, Yaşar Nazligül, Ali̇ Uzunköy Jan 2010

Vitamin C Modulates Oxidative Stress-Induced Colitis In Rats, Mustafa Zeri̇n, Ali̇ Zi̇ya Karakilçik, Muharrem Bi̇ti̇ren, Davut Musa, Abdullah Özgönül, Şehabetti̇n Selek, Yaşar Nazligül, Ali̇ Uzunköy

Turkish Journal of Medical Sciences

Free radicals are an important factor in the etiopathogenesis of colitis and may increase oxidative damage. The antioxidant vitamin C efficiently scavenges free oxygen radicals. The present study aimed to investigate the probable protective effects of vitamin C on oxidative injury in rats in which colitis was experimentally induced with acetic acid. Materials and methods: This study was conducted with rats for a period of 7 days. Group 1 intrarectally received a placebo (0.9% NaCl) and group 2 intrarectally received 2 mL of 5% acetic acid (AA) and the placebo. Group 3 intrarectally received 2 mL of 5% AA and …

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Effects Of Aqueous Garlic Extract On Oxidant/Antioxidant Status In 32d And 32dp210 Cell Lines, Aslihan Avci, Asuman Sunguroğlu, İmge B. Ergüder, Güvem Gümüş Akay, Erdi̇nç Devri̇m, Pinar Özkal Baydin, Nuray Varol, İlker Durak Jan 2010

Effects Of Aqueous Garlic Extract On Oxidant/Antioxidant Status In 32d And 32dp210 Cell Lines, Aslihan Avci, Asuman Sunguroğlu, İmge B. Ergüder, Güvem Gümüş Akay, Erdi̇nç Devri̇m, Pinar Özkal Baydin, Nuray Varol, İlker Durak

Turkish Journal of Medical Sciences

To investigate the possible effects of aqueous garlic extract on the oxidant/antioxidant status and apoptosis in 32D (wild type mouse myeloid cell = normal) and 32Dp210 (BCR-ABL fusion gene (+) mouse myeloid cell = Chronic Myelocytic Leukemia cells) cell lines. Materials and methods: Aqueous garlic extract (10% w/v) was added into the cell line media with 2 different final concentrations (0.4% and 1%). At 0 h and at 24, 48, and 72 h later, the oxidant (malondialdehyde (MDA) level, and xanthine oxidase (XO) enzyme activity) and antioxidant (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities) parameters were …

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Comparison Of In Vitro Cytotoxicity And Genotoxicity Of Mma-Based Polymeric Materials And Various Metallic Materials, Sultan Gülçe İz, Sai̇me İsmet Gürhan, Bi̇lge Hakan Şen, Tuğba Endoğan, Nesri̇n Hasirci Jan 2010

Comparison Of In Vitro Cytotoxicity And Genotoxicity Of Mma-Based Polymeric Materials And Various Metallic Materials, Sultan Gülçe İz, Sai̇me İsmet Gürhan, Bi̇lge Hakan Şen, Tuğba Endoğan, Nesri̇n Hasirci

Turkish Journal of Medical Sciences

To determine the in vitro cytotoxicity and genotoxicity of some polymeric and metallic implant materials used as base materials in dentistry, based on ISO (International Organization for Standardization) and OECD (Organization for Economic Co-Operation and Development) test protocols. Materials and methods: Three different acrylate-based polymeric materials were tested for their in vitro cytotoxicity and genotoxicity (polymethylmethacrylate microspheres [PMMA], a solid cement prepared by mixing PMMA with its monomer methylmethacrylate [PMMA+MMA], a solid cement prepared by mixing PMMA, MMA, and hydroxyapatite [PMMA+MMA+HA], as wells as 4 different metallic materials (titanium [Ti grade 4], nickel alloy 625 [Ni-625], stainless steel alloy 304L …

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Histomorphometric Study On The Effect Of Low Dose Deltamethrin On The Developing Cerebellar Cortex, Mohd Asnizam Asari, Mohammad Shukri Abdullah, Zul Izhar Mohd Ismail Jan 2010

Histomorphometric Study On The Effect Of Low Dose Deltamethrin On The Developing Cerebellar Cortex, Mohd Asnizam Asari, Mohammad Shukri Abdullah, Zul Izhar Mohd Ismail

Turkish Journal of Medical Sciences

Deltamethrin is a widely used type II pyrethroid-based insecticide. Studies have indicated that neonatal exposure to deltamethrin, even at relatively low doses, results in behavioral and neurological changes. In the present study, the effect of early neonatal exposure to low doses of deltamethrin on the histogenesis of the cerebellar cortex was investigated. Materials and methods: Sprague Dawley male pups were exposed to deltamethrin daily at a dose of 1 mg/kg via intraperitoneal injection from the 2nd to the 5th postnatal day and sacrificed on postnatal days 6, 14, and 21. Following intracardiac perfusion, the cerebellum was removed, embedded with paraffin …

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The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz Jan 2010

The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

The effect of the plant-derived nonpsychotropic cannabinoid, cannabidiol (CBD), on the function of hydroxytryptamine (5-HT)3A receptors expressed in Xenopus laevis oocytes was investigated using two-electrode voltage-clamp techniques. CBD reversibly inhibited 5-HT (1 μM)-evoked currents in a concentration-dependent manner (IC50 = 0.6 μM). CBD (1 μM) did not alter specific binding of the 5-HT3A antagonist [3H]3-(5-methyl-1H-imidazol-4-yl)-1-(1-methylindol-3-yl)propan-1-one (GR65630), in oocytes expressing 5-HT3A receptors. In the presence of 1 μM CBD, the maximal 5-HT-induced currents were also inhibited. The EC50 values were 1.2 and 1.4 μM, in the absence and presence of CBD, indicating that CBD acts as a noncompetitive antagonist of 5-HT3 …

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Structure Elucidation Of A Glycosylated Benzyl Ester Of Salicylic Acid From The North American Prairie Plant Oligoneuron Rigidum, Sarah Katherine Miesner Jan 2010

Structure Elucidation Of A Glycosylated Benzyl Ester Of Salicylic Acid From The North American Prairie Plant Oligoneuron Rigidum, Sarah Katherine Miesner

Honors Program Theses

The organic extract from Oligoneuron rigidum displayed anti-microbial activity, indicating a potential future use as a natural food preservative. Three novel compounds were isolated from the active extract. The skeletal structure of the three compounds was determined by spectral methods, and the final structural component that remained to be determined was the locations of the acetate groups. Neutral permethylations were performed on the compounds as the first step in determining the locations of the acetate groups; however, the permethylation technique proved to be ineffective, causing cleavage of the native compounds. The structure elucidation will be complete when a non-degradable method …

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Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković Jan 2010

Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković

Pharmacy Faculty Articles and Research

This review presents a discourse on challenges in understanding and imitating the process of amelogenesis in vitro on the molecular scale. In light of the analysis of imitation of the growth of dental enamel, it also impends on the prospects and potential drawbacks of the biomimetic approach in general. As the formation of enamel proceeds with the protein matrix guiding the crystal growth, while at the same time conducting its own degradation and removal, it is argued that three aspects of amelogenesis need to be induced in parallel: a) crystal growth; b) protein assembly; c) proteolytic degradation. A particular emphasis …

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