Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Mechanical Engineering

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 301 - 330 of 30215

Full-Text Articles in Entire DC Network

Desktop Dynamometer, Ryan Boister, Zachary Chung, Molly Koretz, Tyler Lum Jun 2026

Desktop Dynamometer, Ryan Boister, Zachary Chung, Molly Koretz, Tyler Lum

Mechanical Engineering

This senior project presents the design and development of a desktop dynamometer for measuring the performance of small electric motors. The system integrates torque and speed measurement with data acquisition hardware to calculate power output and evaluate motor performance. The compact and cost-effective design provides a practical platform for engineering education, testing, and performance characterization of small-scale power systems.


25-26 Mecc: Magnetic Thread Wave Energy Converter, Adolfo Torres Flores, Maya Malay, Grayson Houghton, Chase Eavis, Ramyasree Kaja, Tyler Chin, Malia Merager, Chad Haines, Noah Borkum, Raina Moore Jun 2026

25-26 Mecc: Magnetic Thread Wave Energy Converter, Adolfo Torres Flores, Maya Malay, Grayson Houghton, Chase Eavis, Ramyasree Kaja, Tyler Chin, Malia Merager, Chad Haines, Noah Borkum, Raina Moore

Mechanical Engineering

Remote coastal Alaskan villages face significant challenges accessing reliable and affordable electricity due to their geographic isolation and limited connection to central energy grids. These communities often depend on expensive and environmentally unsustainable diesel generators which are difficult to supply and operate. They require a new renewable, affordable, minimal maintenance power solution to decrease their reliance on fossil fuels and promote sustainable development in the region. Although several wave energy converters exist, none adequately suit the needs of these coastal villages, therefore a new design is required to support them. This project will be undertaken by three interdisciplinary teams made …


Smart Sleeve, Evan Abalos, Bright Jung, Owen Bowling, Wyatt Eberhart Jun 2026

Smart Sleeve, Evan Abalos, Bright Jung, Owen Bowling, Wyatt Eberhart

Mechanical Engineering

Quantifying human arm muscle activity is essential for understanding human movements and helping individuals who suffer from motor or neurological impairments such as stroke or traumatic brain injuries. Today, these individuals, as well as clinicians, researchers, and athletes, face many challenges when using the traditional surface electromyography (sEMG) systems to monitor muscle activities, including complex setup, restricted mobility, discomfort, inconsistent placement of electrodes, and lack of accuracy. Therefore, a comfortable EMG sleeve device that accurately measures arm movement without interfering with daily tasks is needed, which the team will be designing, manufacturing, and testing as their senior project. In addition, …


Me Department Bespoke Coffee Cabinet, Mickie Clyne, Stephen Tamacheepjaroen, Samuel Johnson, Willem Gray Jun 2026

Me Department Bespoke Coffee Cabinet, Mickie Clyne, Stephen Tamacheepjaroen, Samuel Johnson, Willem Gray

Mechanical Engineering

This senior project involved the design, fabrication, and testing of a custom coffee cabinet for the California Polytechnic State University Mechanical Engineering Department. The project addressed challenges associated with appliance organization, storage efficiency, accessibility, and maintenance within the department’s shared breakroom space. A human-centered design process was used to identify stakeholder needs and develop engineering specifications for the final product.

The completed cabinet integrates custom woodworking, steel pipe frame construction, dedicated K-Cup storage, organized appliance placement, and a rack-and-pinion sliding platform that improves access to the Keurig coffee maker for refilling and maintenance. Design decisions were informed through stakeholder feedback, …


Mobile Transfer Assist (Mta) Device, Ashley Homuth, Garrett Schnack, Will Bruner, Jacob Flores Jun 2026

Mobile Transfer Assist (Mta) Device, Ashley Homuth, Garrett Schnack, Will Bruner, Jacob Flores

Mechanical Engineering

The Mobile Transfer Assist (MTA) device was developed to assist caregivers with seated-to-seated transfers while reducing physical strain. The device uses a manually operated hand winch and pulley system to raise a user into a semi-standing position, allowing safe transfer between locations. The final design emphasizes portability, affordability, ease of use, and user safety through a modular frame, transfer sling, knee supports, and locking caster wheels. A verification prototype was fabricated and tested, demonstrating successful operation and compliance with project requirements established by VTC Santa Maria.


Hydropower Collegiate Competition 2026, Andres R. Arreola, Sammy D. Taporco, Kathryn E. Tinney, Ahmer S. Dhillon Jun 2026

Hydropower Collegiate Competition 2026, Andres R. Arreola, Sammy D. Taporco, Kathryn E. Tinney, Ahmer S. Dhillon

Mechanical Engineering

The Hydropower Collegiate Competition (HCC) is sponsored by the Department of Energy’s (DOE) Water Power Technologies Office (WPTO) and is meant to offer university students an opportunity to solve complex hydropower challenges, build industry connections, explore career connections, and obtain a greater knowledge of hydropower’s potential in the United States. For this year’s competition, our team investigated a potential in-conduit hydropower site in California. Our work included creating a design package for a crossflow turbine related to our selected site and completing the community connections challenge. We also completed a siting and design report, community connections report, design and siting …


Clipped - A Clipless Bike Grip System, Colin P. Root, Jay Vaughan, Austin Mills, Oscar Weir Jun 2026

Clipped - A Clipless Bike Grip System, Colin P. Root, Jay Vaughan, Austin Mills, Oscar Weir

Mechanical Engineering

This bike grip system works by connecting a magnetic brace to magnetic pucks installed on handlebars to secure the rider. The brace is affixed inside a glove and connects to two retractable pucks to secure a rider using magnetic force only.


Process Improvement For Thermal Barrier Coating Masking Applications, Katherine Meezan, Aiden Senn, Saksham Giri, Katelyn Perez Jun 2026

Process Improvement For Thermal Barrier Coating Masking Applications, Katherine Meezan, Aiden Senn, Saksham Giri, Katelyn Perez

Mechanical Engineering

Solar Turbines, a gas turbine manufacturer, needs a more efficient method to prevent the application of a thermal barrier coating (TBC) to select areas of their combustion liners during manufacturing. Currently, the process is labor, material, and time intensive: reusable masking tools should increase the efficiency of the TBC process.

This project is sponsored in full by Solar Turbines, and is under the guidance and administration of three Solar Turbines engineers: Chris Noone, Rick Rogers, and Carson Roff. The project is mentored by Cal Poly senior design Coach, Rick Lasko. This project will be completed by a team of four …


Me3328 Combined Loading Beam Bending Lab, Alejandro Islas, Viswesh Vancheeswaran, Owen Spencer, Henry Andrews Jun 2026

Me3328 Combined Loading Beam Bending Lab, Alejandro Islas, Viswesh Vancheeswaran, Owen Spencer, Henry Andrews

Mechanical Engineering

Serving as a new laboratory experiment for ME 3328 (Design for Strength & Stiffness), strain gauges were adhered, wired, and calibrated on a cantilever beam lab apparatus capable of undergoing pure bending, pure torsion, and combined bending.


Implementation Of A Line-Scan Camera Triangulation Sensor For A Ball Balancer, Jackson R. Mclaughlin Jun 2026

Implementation Of A Line-Scan Camera Triangulation Sensor For A Ball Balancer, Jackson R. Mclaughlin

Master's Theses

Ball Balancer or Ball on Plate systems are used for education and research in control theory. These consist of a plate which can be actively tilted, with a ball rolling on the surface. Students are challenged to model the dynamics of the system and implement a control loop which is capable of stabilizing the ball by actuating the plate.  The mechatronics group at Cal Poly is developing hardware for one of these ball-balancer systems, for future use in the Mechanical Engineering curriculum.

The position of the ball relative to the plate must be measured in order to control and stabilize …


A Novel Hexagonal-Zigzag Cellular Infill Structure For Additive Manufacturing, Md. Saidur R Roney, Amm Nazmul Ahsan, Prosenjit Barua Jun 2026

A Novel Hexagonal-Zigzag Cellular Infill Structure For Additive Manufacturing, Md. Saidur R Roney, Amm Nazmul Ahsan, Prosenjit Barua

Manufacturing & Industrial Engineering Faculty Publications

The rigidity of the Additively Manufactured objects can be tailored by manipulating the infill lattice type and density. In this research, an island type novel infill structure termed as Hexagonal-Zigzag pattern is introduced, and its mechanical performance is investigated. In this pattern, the zigzag raster reflects the repeating hexagonal shaped cell constituting the parallel-oriented islands and 90° rotation of the pattern in each layer distributes the island span along both transverse and longitudinal directions of the printing contour. A mathematical model is established to illustrate the effect of the infill parameters on hexagon unit cell size and relative infill density. …


Electric Vehicle Charging Station Project, Fangling Zhu Jun 2026

Electric Vehicle Charging Station Project, Fangling Zhu

2026 Spring Reports (Terre Haute)

The electronic vehicle (EV) charging station project was developed through a partnership between BUS 205 Business Statistics at Indiana State University and the City of Terre Haute as part of the Sustainable Cities Program. The city’s goal for this project is associated with the Theme: resilient infrastructure. The strategy RI-1 is to create a more resilient power grid. Terre Haute, aiming to advance sustainability and reduce emissions amidst growing EV adoption, faces challenges of limited charging infrastructure. Students work in four different groups and explore the optimization location for EV charging stations in the City of Terre Haute. The students …


Simulation Of Powder Spreading For Metal Additive Manufacturing, Florence Duff Jun 2026

Simulation Of Powder Spreading For Metal Additive Manufacturing, Florence Duff

Master's Theses

The powder recoating process for Laser Powder Bed Fusion requires iterative experimentation to develop the correct process parameters that will result in high quality parts. There currently lacks good spread quality metrics and models for optimizing spread quality. A machine that simulates the powder spreading process was built to streamline the process of selecting process parameters for specific types of powders without having to operate the full laser system. The parameters investigated were the layer thickness and spreading speed. The response variables were metrics developed to assess spread quality: the percentage of the build plate covered by powder and the …


Wind Power Turbine Pitching, Sierra Bindseil, Olivia Hoffsis, Izik Hingeley, Tucker Donahue Jun 2026

Wind Power Turbine Pitching, Sierra Bindseil, Olivia Hoffsis, Izik Hingeley, Tucker Donahue

Mechanical Engineering

It is crucial that wind turbines are able to control the angle of their blades relative to the wind for optimal performance, efficiency, and safety [1]. This project will design a pitching mechanism for the Cal Poly Wind Power turbine that will compete in the Collegiate Wind Competition (CWC). Currently, for full scale wind turbines, the industry standard design includes the pitch of each blade being controlled by its own individual motor [2]. Because of the smaller scale of Cal Poly Wind Power’s turbine, along with power usage constraints, three separate motors are not a practical approach. Cal Poly Wind …


Cal Poly Fluid Powered Vehicle Challenge 2025/2026, Ethan Malachi Nejame Zeiset, Christian Anthony Cuamani, Daniel Chacon-Bizarro, Marcus Minera, Bradley Hansell Jun 2026

Cal Poly Fluid Powered Vehicle Challenge 2025/2026, Ethan Malachi Nejame Zeiset, Christian Anthony Cuamani, Daniel Chacon-Bizarro, Marcus Minera, Bradley Hansell

Mechanical Engineering

In this Final Design Report, the Cal Poly Fluid Power Vehicle Challenge Contending Team competed in Sun Hydraulics’ 2026 Fluid Powered Vehicle Challenge. The objective of the competition is to expose college students to the fluid power sector, the “hidden giant” of the engineering industry. Specifically, student teams are tasked with the development of a human-powered, fluid-driven vehicle for use in various competitive settings. The team prioritized the optimization of an existing prototype for simplicity, ease of maintenance, and reliability during the competition. The existing prototype exhibited issues related to the main frame’s deflection under load, a lack of gear …


Off-Grid Cabin Hydroelectric Generator, Keller Feltman, Lance Savatgy, River Perino, Jesse Valencia Jun 2026

Off-Grid Cabin Hydroelectric Generator, Keller Feltman, Lance Savatgy, River Perino, Jesse Valencia

Mechanical Engineering

This project developed a portable hydroelectric generator intended to provide low-power electricity generation for an off-grid cabin in Alpine County, California. The system was designed to utilize naturally occurring creek flow to generate electrical power while remaining portable, durable, and environmentally conscious.

The final system consists of an axial-flow turbine, belt-driven generator subsystem, waterproof electronics enclosure, aluminum support frame, and integrated wildlife protection screening. Engineering analysis was performed to estimate hydraulic power availability, turbine performance, drivetrain requirements, and component lifespan. These analyses guided the selection and development of the final design.

Throughout prototype testing, several design modifications were required. Initial …


Multi-Ton Bin Transport Device, Cole Kramer, Ruth Stirrup, Fabian Ruiz, Daniel Ramirez Jun 2026

Multi-Ton Bin Transport Device, Cole Kramer, Ruth Stirrup, Fabian Ruiz, Daniel Ramirez

Mechanical Engineering

This project sought to solve a problem at the Water Resource Recovery Facility in San Luis Obispo with the transportation of multi-ton bins on-site. Their current solutions prove ineffective, as they damage their equipment and the concrete pad, as well as pose major safety risks to the operators moving these bins. The Facility requires the bin transport design to be low-cost, effective, and without risk of damage to the bins or surroundings, while maintaining the integrity of the bins. This project presents a conceptual design that is similar to a scissor lift, integrated into a trailer which will connect to …


Elastic Actuator For Robotic Leg, Bruce Berg, Allan Pham, Madeline Slater, Sofie Zalatimo Jun 2026

Elastic Actuator For Robotic Leg, Bruce Berg, Allan Pham, Madeline Slater, Sofie Zalatimo

Mechanical Engineering

The Cal Poly Legged Robots Group (CPLRG) is developing a 12 degree of freedom robot with the goal of eventually performing highly dynamic movements such as jumps and flips. During such movements, large impact forces will be experienced by the leg, potentially resulting in damage to physical components such as the motors. The scope of this project is to integrate elastic elements into the quadruped legs to reduce shock loads on the motors and improve the efficiency of the legs through energy storage. The key stakeholders for this project are Professor Charlie Refvem and Dr. Simon Xing. Other stakeholders include …


Enhanced Triboelectric Effect Using Functionalized Multiwalled Carbon Nanotube-Coated Fiber Mats For Biomechanical Energy Harvesting, Fernando Viesca, Diego De Leon, Kevin Alejandro, Rigobert Ybarra Jr., Md. Wasikur Rahman, Victoria Padilla, Horacio Vasquez, Karen Lozano, M. Jasim Uddin Jun 2026

Enhanced Triboelectric Effect Using Functionalized Multiwalled Carbon Nanotube-Coated Fiber Mats For Biomechanical Energy Harvesting, Fernando Viesca, Diego De Leon, Kevin Alejandro, Rigobert Ybarra Jr., Md. Wasikur Rahman, Victoria Padilla, Horacio Vasquez, Karen Lozano, M. Jasim Uddin

Mechanical Engineering Faculty Publications

Triboelectric nanogenerators (TENGs) have emerged as a cutting-edge technology for developing self-powered wearable electronic devices. In this study, TENGs were fabricated using two fiber mats: forcespun polytetrafluoroethylene (FS-PTFE) microfibers and electrospun polyvinyl alcohol (ES-PVA) nanofiber (NF) mats. The FS-PTFE mats were coated with functionalized multiwalled carbon nanotubes (MWCNTs). Functionalized MWCNTs were dispersed in water-based solutions containing three different surfactants—sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, and Triton X-100 to enhance fiber interaction. The NF mats were subsequently immersed in aqueous systems. The surfactant facilitated the uniform deposition of COOH-MWCNTs onto the FS-PTFE fibers, serving as a negative layer, while ES-PVA mat …


Design And Optimization Of A Bluff Body For Energy Harvesting Of Transverse Galloping Induced By Low-Speed Wind Using Bernstein Polynomial Equations, Youssef Wael Abdelmoneim Jun 2026

Design And Optimization Of A Bluff Body For Energy Harvesting Of Transverse Galloping Induced By Low-Speed Wind Using Bernstein Polynomial Equations, Youssef Wael Abdelmoneim

Theses and Dissertations

In this thesis, a computational framework is proposed for optimizing the aerodynamic shape of bluff bodies used in galloping-based wind energy harvesters. The system targets low-wind speed environments, where normal wind turbines are not effective, offering a potential alternative to batteries used for powering small electronic devices such as wireless sensors. The design relies on the galloping effect, where airflow around a bluff body induces transverse oscillations that drive an energy conversion mechanism. To generate efficient bluff body geometry, the Class-Shape Transformation (CST) method is used to define a wide range of candidate shapes with minimal design parameters. These shapes …


Capstone Review: Warn Winch Proximity Sensor, Leana Girton Jun 2026

Capstone Review: Warn Winch Proximity Sensor, Leana Girton

University Honors Theses

This thesis reviews the mechanical engineering capstone project that designed a winch proximity sensor for WARN Industries. WARN is very interested in developing this product for market as a safety and ease-of-use accessory, and working with Portland State University was the first step in this process. A group of four mechanical engineering and four electrical engineering capstone students collaborated to research sensor types, test the selected methods, and design and build a prototype. The final design implements an inductive ring, a mechanical button, and bluetooth signaling. The project succeeded in prototyping a proximity sensor for WARN, who will have access …


Design And Implementation Of An Embedded Control System For The Cal Poly Spacecraft Attitude Dynamics Simulator, Neil Mahesh Bedagkar Jun 2026

Design And Implementation Of An Embedded Control System For The Cal Poly Spacecraft Attitude Dynamics Simulator, Neil Mahesh Bedagkar

Master's Theses

This thesis presents the development of a cascaded reaction wheel control system for Cal Poly's Spacecraft Attitude Dynamics Simulator. This work considers system architecture, empirical modeling, high-fidelity simulation, embedded firmware, hardware integration, and experimental characterization. In discrete-time simulation, it is shown that nonlinear direct model reference adaptive control (NDMRAC) enables a nonlinear, partially known plant with realistic actuator dynamics to track the response of a canonical second-order transfer function, with settling time within 4.67% and percent overshoot within order of magnitude of the second-order response. In hardware, the feasibility of a cascaded reaction wheel control architecture is experimentally demonstrated, achieving …


Design And Development Of A Resonance Ignition System Using Gaseous Propellants, Benjamin J. Hoefer Jun 2026

Design And Development Of A Resonance Ignition System Using Gaseous Propellants, Benjamin J. Hoefer

Master's Theses

This work presents the development and experimental evaluation of a resonance igniter (RI) operating with premixed gaseous propellants. Resonance ignition is a non-electrical ignition concept in which an underexpanded jet impinges on a closed-end Hartmann–Sprenger tube (HST), generating cyclic compression and expansion waves that rapidly heat gas near the tube endwall. A modular experimental system was designed and built to investigate resonance ignition using methane–air and methane–oxygen mixtures. The system includes a supplemental configuration that may probe for mixture conditions favorable to ignition, informing RI testing. Pressure and temperature measurements were used to characterize pressure control, mixture pressure ratio (MPR), …


Characteristic Stress And Strain Optimization Of Cardiovascular Catheters With Laser-Cut Hypotubes Using Finite Element Analysis, Kyle E. Hirth Jun 2026

Characteristic Stress And Strain Optimization Of Cardiovascular Catheters With Laser-Cut Hypotubes Using Finite Element Analysis, Kyle E. Hirth

Master's Theses

Cardiovascular catheter systems rely on laser-cut hypotubes to balance flexibility and structural integrity required for minimally invasive surgical procedures.  Optimizing these mechanical characteristics remains a significant challenge.  This study aims to investigate the influence of key laser-cut geometric parameters on the mechanical performance of hypotubes through finite element analysis.

Commercially representative laser-cut hypotubes were modeled and a finite element model was developed.   Geometric design parameters were varied across a design space consisting of pitch values ranging from 0.006 in. to 0.018 in. and cuts per revolution (CPR) ranging from 2.5 – 4.5.  For each pitch and CPR combination, loading stiffness …


Aerodynamic Design And Structural Evaluation Of A Global Minimum Torque Inspired Multirotor Propeller, Zeke Bukovansky Jun 2026

Aerodynamic Design And Structural Evaluation Of A Global Minimum Torque Inspired Multirotor Propeller, Zeke Bukovansky

Master's Theses

This thesis develops a repeatable design, CAD, aerodynamic postprocessing, structural screening, and manufacturing feasibility workflow for a 22-inch global minimum torque inspired multirotor propeller. Matched MIL and GMT geometries were compared at a 35 N, 4000 rpm static-hover operating condition using BEMT/XFOIL aerodynamic postprocessing, with diameter, blade count, chord distribution, airfoil schedule, and target thrust held constant. The final modeled comparison predicted a modest 1.5% reduction in torque and shaft power for the GMT case while maintaining the same thrust target. CAD construction, MATLAB reduced-order beam model, Abaqus screening, and manufacturing planning were used to identify geometry level structural and …


Design And Evaluation Of An Assistive Powered Hand Orthosis For Grasp Activities For People Post-Stroke, Sydney Alexander Jun 2026

Design And Evaluation Of An Assistive Powered Hand Orthosis For Grasp Activities For People Post-Stroke, Sydney Alexander

Master's Theses

After suffering a stroke, many survivors experience physical disability that affects their ability to complete daily tasks using their hands. Physical therapy is often pre scribed to people post-stroke, but is not fully effective at restoring hand function. The goal of this project was to design and fabricate an assistive device for people post-stroke to help with grasp and release. The device was designed to address com mon shortcomings of existing similar devices. State of the art devices in this domain were investigated to determine a set of design improvements. A novel motor-actuated hand orthosis was designed to decrease weight, …


Investigation Of Process Parameters To Fabricate Tiwmo Refractory Medium Entropy Alloy Via Laser Powder Bed Fusion, Abdullah Al Masum Jabir, Lindsey A. Salazar, Jianzhi Li Jun 2026

Investigation Of Process Parameters To Fabricate Tiwmo Refractory Medium Entropy Alloy Via Laser Powder Bed Fusion, Abdullah Al Masum Jabir, Lindsey A. Salazar, Jianzhi Li

Manufacturing & Industrial Engineering Faculty Publications

This paper presents an experimental study on the fabrication of a TiWMo refractory medium-entropy alloy (RMEA) using laser powder bed fusion (PBF-LB/M, commonly known as selective laser melting) from elemental powders as well as successful alloy formation on titanium substrates. The effects of tungsten particle size and process parameters on successful TiWMo RMEA fabrication have been explored using scanning electron microscopy (SEM), x-ray diffraction, hardness measurement and microstructural analysis. Scanning electron microscope (SEM) analysis revealed that the lowest percentage (0.01%) of unmelted tungsten particles was observed at a laser power of 350 W and scanning speed of 250 mm/s, particularly …


Design And Parametric Study Of A Mems-Based Reservoir Computer For Reinforcement Learning, Andrew P. Carr Jun 2026

Design And Parametric Study Of A Mems-Based Reservoir Computer For Reinforcement Learning, Andrew P. Carr

Master's Theses

Single-node reservoir computing (RC) is a hardware-efficient approach to machine learning, leveraging the dynamics of physical systems. In this work, two reinforcement learning algorithms, Q-learning and Proximal Policy Optimization (PPO), are applied to a simulated micro-electro-mechanical system (MEMS)-based reservoir computer to solve both discrete and continuous control tasks. MEMS-based reservoirs are low-power, compact, and their natural frequencies (kHz to MHz) pair well with real-time control loops. To explore the relationship between reservoir dynamics and learning performance, a parametric study is conducted on two reservoir hyperparameters, reservoir size and neuron separation, using CartPole-v1 and MountainCar-v0. The RC successfully learns multiple tasks …


Design For Repairability: Analyzing The Evolution Of Smartphone Repairability To Generate Design Insights, Pranav Peddinti Jun 2026

Design For Repairability: Analyzing The Evolution Of Smartphone Repairability To Generate Design Insights, Pranav Peddinti

Master's Theses

Smartphones are a major part of daily life, allowing people to communicate, browse the internet, shop, and enjoy entertainment. However, smartphones tend to be replaced quickly and therefore contribute to the growing electronic waste problem. The lifecycle of a smartphone can be extended by designing them to be more repairable, making it easier for owners and users to perform the repairs themselves. By only replacing failing components, the device can be in use longer, reducing the waste and pollution generated by replacing the device entirely. Therefore, product designers and engineers must focus on designing smartphones to be more repairable. Design-for-repairability …


Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel Jun 2026

Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel

Dissertations, Theses, and Capstone Projects

Nucleosome core particles (NCP) are the building blocks that form a highly organized and compact chromatin structure. Nucleosomes package DNA in the nucleus of eukaryotic cells. The NCP consists of about 147 base pairs of DNA wrapped around the histone octamer, with 1.65 superhelical turns in a left-handed manner. The histone octamer is composed of two copies of H3, H4, H2A, and H2B. Together with histone H1 and linker DNA, they further assemble into a higher-order chromatin structure. The nucleosome complex is stabilized by electrostatic interactions between positively charged histone residues and the negatively charged DNA backbone. To effectively access …