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Understanding Glufosinate Resistance In Palmer Amaranth And Examination Of Additives For Improved Weed Control, Pamela Carvalho-Moore

Graduate Theses and Dissertations

The aim of this dissertation was to: 1) provide an in-depth review about the potential use of natural and synthetic glutathione S-transferase (GST) inhibitors to enhance herbicidal activity or induce crop safety; 2) determine if the addition of metabolic inhibitors to glufosinate is an effective approach to enhance weed control; 3) investigate the mechanism conferring resistance to glufosinate in a highly-resistant Palmer amaranth accession; 4) characterize the genomic rearrangement involved in glutamine synthetase 2 amplification in a Palmer amaranth accession resistant to both glufosinate and glyphosate; 5) quantify the distribution of glufosinate resistance among Palmer amaranth accessions within a 15-km …

Dual Investigations Into Broiler Health: Mitochondrial Gene Expression In Ascites Susceptibility And G-1,25(Oh)₂D₃-Driven Modulation Of Bone And Gut Integrity In Lameness, Layla Hussein Al-Mitib

Graduate Theses and Dissertations

Modern broiler production faces persistent challenges from metabolic and skeletal disorders, particularly ascites and bacterial chondronecrosis with osteomyelitis (BCO), which compromise animal welfare and production efficiency. This dissertation examines two key factors that contribute to these conditions: mitochondrial gene expression associated with pulmonary hypertension syndrome (PHS) and the role of intestinal barrier integrity in mitigating lameness. In the first study, the expression of mitochondrial genes COXII and ATP6 was evaluated in the breast, thigh, and lung tissues of three broiler genetic lines—ascites-susceptible (SUS), ascites-resistant (RES), and unselected relaxed (REL). While no significant expression differences were observed in muscle tissues, SUS …

Auricular Point Acupressure For Older Adults With Chronic Low Back Pain: A Randomized Controlled Trial, Jennifer Kawi, Chao Hsing Yeh, Nada Lukkahatai, Hulin Wu, Natalia E Morone, Ronald Glick, Elizabeth A Schlenk, Claudia Campbell, Johannes Thrul, Xinran Huang, Hongyu Wang, Hejingzi Monica Jia, Paul Christo, Constance Johnson

Faculty, Staff and Student Publications

Objective: Efficacious modalities are limited in chronic low back pain (cLBP). We determined the efficacy of auricular point acupressure (APA) in older adults with cLBP.

Design: 3-arm randomized controlled trial.

Setting: Baltimore, Maryland.

Participants: Participants, ≥60 years with cLBP, were randomized (1:1:1) to APA with ear points targeted to cLBP (T-APA, n = 92), points nontargeted to cLBP (NT-APA, n = 91), or waitlist education control (n = 89), and followed up to 6 months (6M). Participants in the APA groups received 4 weekly APA sessions; the education control group received 4 weekly educational sessions.

Intervention: APA.

Main outcomes and …

Exploring Boundaries With Food, Substances, And People In Substance Use Recovery: A Qualitative Analysis, Tiffany Champagne-Langabeer, Audrey Sarah Cohen, Kriti Shrestha, Jie Zhu, Audrey Lopez, Alisha Campbell, Christine Bakos-Block

Faculty, Staff and Student Publications

Background: In the United States, over 47 million youth and adults live with a substance use disorder (SUD). These individuals are frequently malnourished and have metabolic dysregulation as a result. Nutrition interventions incorporating a mindfulness-based approach help recovery efforts that are physical and mental.

Objective: The objective of this study was to explore and analyze the perspectives and experiences of individuals with SUD regarding emotional regulation and nutrition. The study used a mixed methods approach to generate insights for improving recovery support and developing future interventions.

Design: In 2024, an exploratory mixed methods study was conducted based on a large …

Implementation Of Screening And Assessment Tools For Diagnosing Opioid Use Disorder: A Systematic Review, Audrey Lopez, Audrey Sarah Cohen, Francine Vega, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

Introduction: As the prevalence of opioid use disorder (OUD) continues to rise, early detection by medical professionals can often be the first step in linking individuals to treatment. This systematic review was designed to identify implemented OUD screening and assessment tools with studies published from January 2019 through June 2024, uncover common themes associated with implementation, and determine if these tools were recommended in clinical practice.

Methods: A systematic literature search was conducted within PubMed, EMBASE, and Web of Science using the keywords 'opioid use disorder,' 'documentation,' and 'screening assessment tool.' Three investigators independently reviewed titles, abstracts, and full-text articles …

Volatile Pyrethroid Spatial Repellents For Preventing Mosquito Bites: A Systematic Review And Meta-Analysis, Ingrid Chen, Sarah L. Miller, Daniel Msellemu, Aidi G. Lugenge, Johnson Kyeba Swai, Nicole Achee, Marta Andrés, Christopher S. Bibbs, Theeraphap Chareonviriyaphap, J. Derek Charlwood, Greg Devine, Noel Elman, Ulrike Fillinger, Carmen Flores-Mendoza, Seth Gibson, Nicodem Govella, Steven Gowelo, Sebastian Horstmann, Hitoshi Kawada, Daniel Kline, Aaron Lloyd, Neil F. Lobo, Marta F. Maia, Arnold Mmbando, Mara Moreno-Gómez, Amy C. Morrison, Winifrida Mponzi, Emmanuel P. Mwanga, Margaret Njoroge

All Peer-Reviewed Publications

Background: Volatile pyrethroid spatial repellents (VPSRs) can prevent mosquito-borne diseases including malaria and dengue fever, but the use of varied evaluation methods has resulted in a lack of clarity regarding their protective efficacy (PE) against contact with mosquitoes. This systematic review and meta-analysis consolidates the entomological evidence base on the PE of VPSRs against Anopheles, Aedes, and Culex mosquitoes and different test methods used. Methods: We identified studies completed between January 2000 and September 2023 by searching through databases, conference abstracts, and personal correspondences. Included studies were semi-field or field studies that measured the PE of VPSRs using human landing …

Maize Yield Stability Under Organic And Conventional Farming Systems In Sub-Humid Agro-Ecozones Of Central Kenya, Milka Kiboi, David Bautze, Felix Matheri, Amritbir Riar, Andreas Fliessbach

All Peer-Reviewed Publications

Maize (Zea mays L.) is the main staple crop and is important to the food security and livelihoods of people globally. We evaluated the effects of organic and conventional farming systems on maize grain yield and temporal yield stability under different external input levels in a long-term experiment (2007–2022) at two sites in Kenya. We implemented four farming systems: organic high (Org-High), conventional high (Conv-High), organic low (Org-Low), and conventional low (Conv-Low) in a randomized complete block design. Growth indicators for maize, height, stem diameter, and grain yield were higher in high input systems, but grain yield stability was not. …

Spatial Distribution Of Microsporidia Mb Along Clinal Gradient And The Impact Of Its Infection On Pyrethroid Resistance In Anopheles Gambiae S.L. Mosquitoes From Nigeria And Niger Republic, Lamine M. Moustapha, Muhammad M. Mukhtar, Abdoul Nasser H. Sanda, Shuaibu Adamu, Yusuf Y. Aliyu, Hadizat K. Einoi, Maryam U. Maigari, Peter C. Okeke, David E. Nwele, Abiodun Obembe, Udoka C. Nwangwu, Jeremy K. Herren, Sulaiman S. Ibrahim

All Peer-Reviewed Publications

Microsporidia MB (MB), a promising biological control agent, suppresses Plasmodium falciparum transmission in Anopheles mosquitoes. This study examined the spatial distribution of MB infection in natural populations of An. gambiae s.l. mosquitoes collected in Nigeria and Niger Republic, and its association with insecticide susceptibility in the mosquitoes. Microsporidia MB has wide geographic distribution across Nigeria and Niger Republic. The overall prevalence of MB in F0 mosquitoes was 12.25% (95% CI: 7.76–16.75%); 25 mosquitoes out of 204 were positive. Geographic variation was observed, with a higher prevalence (5/15 mosquitoes) in Ebonyi State (33.33%, CI: 9.48–57.19%, Fisher’s exact test, p = 0.008). …

Miscanthus × Giganteus Increases Soil Maximum Water Holding Capacity Compared To Maize, Jessica T. Nelson, Maoz Dor, Andy D. Vanloocke, Jacob E. Studt, Perla K. Schrock, Marshall D. Mcdaniel

School of Earth, Environmental, & Marine Sciences Faculty Publications

Soil ecosystem services, like the ability to store water, have been depleted after a century of conventional, annual cropping, and perennial crops offer a solution to this and other agricultural environmental issues. We assessed the impact of Miscanthus × giganteus (miscanthus), a perennial biomass crop, on soil water holding capacity and structure compared to continuous maize (Zea mays L.) at two sites in Iowa. After three growing seasons, we measured the following: (1) maximum water holding capacity (MWHC) with and without soil structure, and (2) total porosity and pore size distribution (PSD) via micro-computed tomography (microCT). Miscanthus increased MWHC …

Wood-Water Relationship And Micro-Chemical Properties Of Huminated Archaeological European Elm (Ulmus Laevis P.), Amir Ghavidel, Shennan Wang, Miklós Bak, Lauri Rautkari, Reza Hosseinpourpia

Michigan Tech Publications

Archaeological wood requires effective conservation to prevent further degradation, and traditional modifications such as polyethylene glycol (PEG) have limitations, including hygroscopicity and chemical degradation over time. To explore alternative modification, this study was conducted to investigate the suitability of humins, crosslinked with different concentrations of succinic acid (SA), to protect archaeological elm wood from the Agapia Monastery against water and to determine the modification mechanism. Key parameters such as dimensional stability, moisture sorption isotherms, and determination of accessible hydroxy groups as a function of humination modification were analyzed using dynamic vapor sorption (DVS). The modification mechanism was studied by microstructural …

Durability Of Tannin-Citric Acid Modified Scots Pine Against Weathering And Fungal Exposures, Sheikh Ali Ahmed, Gianluca Tondi, Reza Hosseinpourpia

Michigan Tech Publications

Wood modification is essential to enhance the performance and longevity of wood as a material while maintaining its natural and sustainable characteristics. By modifying wood, its properties can be significantly improved without the need for toxic preservatives. Thus bio-based wood modification is vital for enhancing wood properties sustainably, reducing environmental impact, and meeting the demand for eco-friendly, non-toxic, and renewable material solutions. In this study, bio-based formulae were used on pine sapwood for enhanced decay and weathering resistance. Quebracho tannin solutions (20 %) with different concentrations of citric acid (CA) as a cross-linker were prepared and then vacuum-pressure impregnated in Scots …

The Evolution And Reproduction Of Andean Miconia (Melastomataceae), Juan Angulo

Dissertations, Theses, and Capstone Projects

Understanding the factors that shape diversification and distribution in tropical plant lineages is central to explaining the origins of Neotropical biodiversity. Assessing evolutionary history with trait evolution and climatic niche dynamics provides key insights into the drivers of diversification and biogeography, while natural history data remains critical for these evolutionary studies. The Tropical Andes, with its exceptional biodiversity and environmental heterogeneity, offers an ideal setting to explore these processes. In this dissertation, I investigate how reproductive systems, climatic niche dynamics, and pollination strategies influence the evolution and biogeography of Miconia III, a large and ecologically diverse clade in the …

From Sequence To Allostery: How Amino Acid Differences Rewire Coupled Conformational Heterogeneity In The Ptp Enzyme Family, Shivani Sharma

Dissertations, Theses, and Capstone Projects

Protein Tyrosine Phosphatases (PTPs) are critical regulators of cellular signaling, and their activity is often modulated through allosteric mechanisms. Allostery is defined as a chemical or conformational change in one site of the protein due to a binding event at another site. Although several studies have investigated aspects of allostery in PTPs, the mechanistic foundations underlying allosteric regulation remain poorly understood. Despite a highly conserved catalytic domain across PTPs, regions with low or no conservation suggest potential "rewiring" of allosteric networks. This raises key questions about the universality versus individuality of allosteric mechanisms across the PTP family.

In this work, …

Systematics, Biogeography, And Comparative Morphology Of Emerald And Tigertail Dragonflies (Anisoptera: Synthemistidae & Corduliidae), Aaron M. Goodman

Dissertations, Theses, and Capstone Projects

Dragonflies and damselflies (Odonata Fabricius, 1793) are among the most widely recognized and charismatic insect groups, whose significance have permeated throughout artwork, culture, and religion. They are highly mobile predators, currently consisting of ~ 6,500 species, and possessing some of the complex visual color systems, visual acuity, and flight patterns on Earth. Odonata are the among the earliest flying insects, with proto-odonates (Griffinflies) dating back to the Carboniferous (~360mya), with crown-odonata fossils stretching back to the Triassic (~250mya). Overall, dragonflies and damselflies are considered models of ecological and evolutionary research due to their long evolutionary history, range of habitats, and …

Ai-Powered Multi-Omics Integration For Predictive Modeling Of Genotype-Environment-Phenotype Relationships, You Wu

Dissertations, Theses, and Capstone Projects

This dissertation presents a series of machine learning frameworks for modeling genotype–environment–phenotype relationships through integrative predictive modeling of multi-omics data. The work addresses three major axes of biological complexity: modeling biological information transmission cross-levels from genes to proteins to phenotypes, predicting molecular features cross-scale from cells to tissues to organisms, and translating phenotypes cross-species from model systems to humans. Each proposed method also tackles key machine learning (ML) challenges in the biomedical domain, including data scarcity, domain shift, out-of-distribution (OOD) generalization, and hierarchical modeling. Specifically, this dissertation introduces five novel deep learning algorithms: MultiDCP predicts drug-induced transcriptomic and viability responses …

Exploring The Role Of Ecological Traits In Shaping Spatial Patterns Of Genetic Diversity, Rilquer Mascarenhas Da Silva

Dissertations, Theses, and Capstone Projects

The field of comparative phylogeography aims at uncovering common underlying causes for shared patterns of diversity and diversification at the population level. However, it is now widely accepted that intraspecific genetic diversity patterns can differ considerably across co-occurring taxa due to ecological processes acting at the population level (and influencing individual movement and abundance). To model the processes underlying lineage diversification and demographic shifts in response to environmental changes, phylogeographers and population geneticists are now faced with the challenge of incorporating measurements of species ecological traits into their molecular studies. This dissertation aimed at investigating how different types of ecological …

Retinal Precursor Cell Enriched Multiomic And Pseudo-Time Analysis Of Developing And Reprogrammed Photoreceptors, Brendon M. Patierno

Dissertations, Theses, and Capstone Projects

The vertebrate retina is a complex tissue made up of seven major cell subtypes which during development must differentiate and localize into a highly organized structure. These neuronal cells do not regenerate if damaged or diseased, and the progressive deterioration of cone photoreceptor cells is the leading cause of age related blindness. Currently there are no cures for this disease, but one promising therapeutic avenue is cell transplantation research. If we can further elucidate the gene regulatory networks that define cone cell development, this knowledge could be applied to the generation of healthy cone cells in clinically relevant models.

The …

The Sonic Hedgehog Effector Smoothened Modulates Cholinergic Interneuron Activity, Physiology, And Striatum-Dependent Behaviors, Santiago Uribe-Cano

Dissertations, Theses, and Capstone Projects

The striatum is a central node in action selection and associative learning, integrating cortical, thalamic, and neuromodulatory input. Among its principal modulators, dopamine (DA) and acetylcholine (ACh) are known for their temporally coordinated yet mechanistically distinct influences on striatal output. However, the upstream signals that regulate their dynamic interplay, particularly within cholinergic interneurons (CINs)—the primary source of striatal ACh—remain incompletely characterized. This dissertation investigates the role of Smoothened (Smo), a G protein-coupled receptor (GPCR) effector of Sonic Hedgehog (Shh) signaling, in modulating ACh signaling dynamics in the striatum.

Building on evidence that midbrain DA neurons co-release Shh and that CINs …

Mechanistic Insights Into The Neuroprotective Effects Of The Antidepressant Agomelatine In Alzheimer's Disease, Grace Terry

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease (AD) is a complex neurodegenerative disease that has limited treatment options and no cure. AD is characterized by robust pathology including extracellular amyloid beta plaques, intracellular neurofibrillary tangles, neuronal and synaptic loss, neuroinflammation, and brain atrophy. AD presents with cognitive decline and memory loss but only years after neuropathology has started to accumulate. This robust pathology has made AD difficult to treat and highlights the need for therapeutics that modulate multiple pathways. Agomelatine (AGO) was selected by a high-throughput machine learning drug repurposing algorithm by our collaborator Dr. Lie Xie (Hunter College Dept. of Comp. Sci.) as having …

Unveiling The Precision Of Physiological Signals In Prediction Error During Fear Learning: Insights From Associative Strength And Generalized Uncertainty, Haja H. Jallo-Jamboria

Dissertations, Theses, and Capstone Projects

Prediction error (PE) is the discrepancy between expected and actual outcomes. It is a central mechanism in associative learning particularly within fear-conditioning paradigms. Identifying physiological markers of PE in aversive contexts has important implications for refining learning models and enhancing clinical interventions for anxiety-related disorders. This study examined skin conductance response (SCR) as a potential physiological index of PE by analyzing both anticipatory and omission-related responses across multiple learning phases. Participants completed a Pavlovian fear-conditioning paradigm in which two conditioned stimuli (CS+) signaled threat at different reinforcement probabilities: CS+100 (certain threat) and CS+50 (uncertain threat), alongside a non-reinforced safety cue …

Behavioral Biomarkers Of Vulnerability In The Aba Model, Nora Ozer

Dissertations, Theses, and Capstone Projects

Anorexia nervosa (AN) is a severe psychiatric disorder with the highest mortality rate among mental health conditions, yet effective biological treatments remain limited. The activity-based anorexia (ABA) paradigm, which combines food restriction with wheel access to model the hyperactivity and self-starvation cycle characteristic of AN, shows considerable individual variability in vulnerability. Understanding what predisposes certain individuals to develop the full ABA phenotype while others remain resilient could inform early intervention strategies for human AN. This study employed continuous behavioral monitoring technology to identify early predictors of vulnerability to activity-based anorexia in mice, with the goal of discovering behavioral biomarkers that …

Comparison Of Gonad Development Between Wild And Hatchery-Bred Silver Therapon Leiopotherapon Plumbeus (Teleostei: Terapontidae) During An Annual Reproductive Cycle, Frolan A. Aya, Samantha Ally V. Bismonte, Mary Jane P. Sayco, Luis Maria B. Garcia

The Philippine Agricultural Scientist

This study compared gonad development between wild-sourced and hatchery-bred silver therapon Leiopotherapon plumbeus. Wild fish from the east bay area of Laguna de Bay, Philippines, and hatchery-bred stocks grown to adult size in outdoor tanks were sampled, and somatic condition, gonad histology, gonadosomatic index (GSI), gut index (GI), and hepatosomatic index (HSI) were assessed during the annual reproductive cycle. Hatcherybred fish condition was generally better than that of wild-sourced fish as a consequence of readily available food resources and environmental conditions. Hatchery-bred male GSIs were significantly higher than in wild male fish in November to February, coinciding with low water …

Genetic And Geographic Profiling Of Fragrance-Associated Badh2 Mutations In Rice From China, Laos, And Vietnam, Lenie A. Quiatchon-Baeza, Venea Dara Daygon, Mariafe N. Calingacion, Melissa A. Fitzgerald

The Philippine Agricultural Scientist

Fragrance in rice is a culturally and economically significant trait in Asia and around the world. This study aimed to develop a genetic and geographic profile of the fragrance-associated BADH2 mutations (badh2.1 and badh2.11) in 1,067 rice varieties from China, Laos, and Vietnam, which are part of the International Rice Genebank Collection. Seventy-three varieties were found to carry the common eight-base pair (bp) deletion in exon 7 of the genes (badh2.1, also known as badh2.7), primarily from indica varieties, with some belonging to japonica, javanica, and intermediate varieties. Conversely, 59 varieties possess the recently identified badh2 allele, badh2.11 (also known …

Impact Of Sowing Time And Plant Density On Selected Traits And Yield Of Cotton Genotypes In Pakistan, Muhammad Rizwan Jamil, Kalim Ullah, Muhammad Mohibullah, Saeed Muhammad, Hafiz Abdul Haq, Sundas Batool, Rashida Aslam, Wasif Rasool

The Philippine Agricultural Scientist

Extremely diversified cropping environments prevail in most cotton-growing areas of Pakistan due to prevailing rainfed conditions, prolonging the crop’s cultivation period. To contribute to the development of desired breeding traits for effective breeding programs, this study examined the production and growth pattern of 8 cotton genotypes. Four experiments were conducted in 2018 and 2019 at 2 locations in Dera Ismail Khan, Pakistan, to evaluate the performance of the studied genotypes at 3 plant densities and 2 sowing dates. Traits such as days to first flower opening, flowering duration, monopodial branches per plant, plant height at harvest, height-to-node ratio, fruiting branch …

Growth Performance And Yield Of Two Bioguma Sorghum Varieties Cultivated During The Rainy Season [Research Note], M. Umar Harun, Irmawati Irmawati, Marlin Sefrila, Astuti Kurnianingsih, Chandra Irsan

The Philippine Agricultural Scientist

Sorghum is a cereal crop with significant potential, considering its benefits as a food, feed, or bioethanol source. Aside from being a drought-tolerant plant, sorghum can grow in different land conditions, with varieties Bioguma 1 and 2 considered to have high yield potential. Therefore, this study aimed to assess the growth and yield of these 2 sorghum varieties using a randomized block design with 3 replicates. The results showed that Bioguma 1 had a significantly better growth performance and produced a higher yield compared with Bioguma 2. Considering its higher disease resistance, growth, and yield, Bioguma 1 could be used …

Time-Frequency Fingerprint Analysis In Seeg Source-Space To Identify The Epileptogenic Zone, Yash Shashank Vakilna, Deniz Atilgan, Johnson Hampson, Chinmay Chinara, Takfarinas Medani, Richard M Leahy, Nuria Lacuey, Samden D Lhatoo, Sandipan Pati, John C Mosher, Jay R Gavvala

Faculty, Staff and Student Publications

This case study highlights the application of seizure fingerprint analysis in the source-space of stereo-EEG (SEEG) data to accurately localize the epileptogenic zone (EZ) in patients with complex cortical malformations. A 25-year-old female with extensive bilateral perisylvian polymicrogyria (PMG) presented with intractable focal seizures. The source-level analysis performed in Brainstorm using the sLORETA imaging algorithm subsequently showed EZ fingerprint analysis. The patient underwent MR-guided laser interstitial thermal therapy (LITT), targeting the identified EZ, resulting in postoperative seizure freedom with minimal complications. Extending the analysis from the sensor-space to the source-space could further enhance surgical planning and improve outcomes in complex …

Elephant Endotheliotropic Herpesvirus 2 Infection In 5 African Elephants (Loxodonta Africana) At Multiple North American Zoological Institutions, Taylor J Willis, Anne Burgdorf-Moisuk, Maren Connolly, Jan Raines, Cameron Ratliff, Zoltan S Gyimesi, Erica Lipanovich, Genevive A Dumonceaux, Kathryn L Perrin, Lauren L Howard, Matthew E Kinney, Kirk Suedmeyer, Erin Latimer, Tiffany L Kim, Jessica R Watts, Jie Tan, Paul Ling

Faculty, Staff and Students Publications

Objective: To acknowledge that elephant endotheliotropic herpesvirus (EEHV) is a well-recognized major threat to Asian elephants (Elephas maximus) and can cause acute and often fatal hemorrhagic disease (HD). Historically, EEHV-HD has been less frequently identified in African elephants (Loxodonta africana). This case series describes 5 recent cases of EEHV2 infection in African elephants within managed care at 5 North American institutions.

Animals: 5 African elephants (L africana).

Clinical presentation: The cases involved 4-, 7-, and 10-year-old males that died despite receiving aggressive medical therapy and 4- and 14-year-old females that survived. Clinical signs included lethargy, decreased appetite, lameness, changes in …

A Consensus Guide To Preclinical Indirect Calorimetry Experiments, Alexander S Banks, David B Allison, Thierry Alquier, Ansarullah, Steven N Austad, Johan Auwerx, Julio E Ayala, Joseph A Baur, Stefania Carobbio, Gary A Churchill, Morten Dall, Rafael De Cabo, Jose Donato, Nathalia R V Dragano, Carol F Elias, Anthony W Ferrante, Brian N Finck, Jose E Galgani, Zachary Gerhart-Hines, Laurie J Goodyear, Justin L Grobe, Rana K Gupta, Kirk M Habegger, Sean M Hartig, Andrea L Hevener, Steven B Heymsfield, Corey D Holman, Martin Hrabě De Angelis, David E James, Lawrence Kazak, Jae Bum Kim, Martin Klingenspor, Xingxing Kong, Sander Kooijman, Louise Lantier, K C Kent Lloyd, James C Lo, Irfan J Lodhi, Paul S Maclean, Owen P Mcguinness, Gema Medina-Gómez, Raghavendra G Mirmira, Christopher D Morrison, Gregory J Morton, Timo D Müller, Yoshihiro Ogawa, David Pajuelo-Reguera, Matthew J Potthoff, Nathan Qi, Marc L Reitman, Patrick C N Rensen, Jan Rozman, Jennifer M Rutkowsky, Kei Sakamoto, Philipp E Scherer, Gary J Schwartz, Radislav Sedlacek, Mohammed Selloum, Saame Raza Shaikh, Shuai Chen, Gerald I Shulman, Vojtěch Škop, Alexander A Soukas, John R Speakman, Bruce M Spiegelman, Gregory R Steinberg, Katrin J Svensson, John P Thyfault, Tony Tiganis, Paul M Titchenell, Nigel Turner, Licio A Velloso, Antonio Vidal-Puig, Christopher S Ward, Ashley S Williams, Christian Wolfrum, Allison W Xu, Ying Xu, Juleen R Zierath, International Indirect Calorimetry Consensus Committee (Iiccc)

Children’s Nutrition Research Center Staff Publications

Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure. Using measurements of respiratory gas exchange, indirect calorimetry can provide non-invasive estimates of whole-body energy expenditure. However, inconsistent measurement units and flawed data normalization methods have slowed progress in this field. This guide aims to establish consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results. By establishing community-driven standards, we hope to facilitate data comparison across research datasets. This advance will allow the creation of an in-depth, machine-readable data …

From Imaging To Impact: A Multi-Disciplinary T32 Program Framework And Initial Insights For Training In Image-Guided Cancer Therapy, Kari J Brewer Savannah, Stephen Y Lai, Clifton D Fuller, Kristy K Brock

Faculty, Staff and Student Publications

As multi-disciplinary image-guided assessment and therapies become increasingly important for precision oncology, the need for comprehensive training opportunities that effectively prepare the next generation of clinician-scientists and scientists is evident. We present an innovative, evidence-based research training framework that integrates the following critical features: 1) intentional and personalized mentoring and career development, 2) immersive research in image-guided cancer therapy, 3) strategic mentored clinical exposure, 4) structured didactic learning and professional development opportunities, and 5) mentored grant writing. Designed to foster scientific rigor, translational thinking, and multi-disciplinary collaboration, the Image-Guided Cancer Therapy T32 Training Program (IGCT-T32) aims to prepare postdoctoral fellows …

Author Correction: Clonal Evolution Of Hematopoietic Stem Cells After Autologous Stem Cell Transplantation, Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Deepak Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Linda Zhang, Jennifer Padilla, Li Zhao, Joanne I Hsu, Chong Zhao, Shujuan Chen, Tomoyuki Tanaka, Zongrui Li, Satoko Ogata, Sarah Hanache, Hui Yang, Courtney Dinardo, Naval Daver, Naveen Pemmaraju, Nitin Jain, Farhad Ravandi, Jianhua Zhang, Xingzhi Song, Erika Thompson, Hongli Tang, Latasha Little, Curtis Gumbs, Robert Z Orlowski, Muzaffar Qazilbash, Kapil Bhalla, Simona Colla, Hagop Kantarjian, Rashmi Kanagal-Shamanna, Carlos Bueso-Ramos, Daisuke Nakada, Gheath Al-Atrash, Jeffery Molldrem, P Andrew Futreal, Elizabeth Shpall, Margaret Goodell, Guillermo Garcia-Manero, Koichi Takahashi

Faculty, Staff and Student Publications

No abstract provided.