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Articles 7441 - 7470 of 256732
Full-Text Articles in Entire DC Network
A Bioarchaeological Study Of The Individuals From The Városfalva Burial Mound In Transylvania, Romania (15th-19th Century), Vanessa C. Reeves
A Bioarchaeological Study Of The Individuals From The Városfalva Burial Mound In Transylvania, Romania (15th-19th Century), Vanessa C. Reeves
USF Tampa Graduate Theses and Dissertations
This study explores the lives and deaths of the Szekler people recovered from a burial mound in the Transylvanian village of Városfalva. The Transylvanian plateau is located in present day Romania, and is protected on the east and the south by the Carpathian Mountains. The Szekler people arrived in this area around 1000 CE, and were a nomadic group originating in the Asian Steppes region who later intermarried with various migratory groups as they moved across the Eurasian plains. The Szeklers eventually banded together with the proto-Hungarian Magyar peoples and settled in the Carpathian Basin, the easternmost frontier of the …
Managed Online Panel Discussions As A Participatory Education Approach, Melissa M. Kreye, Kathryn Brooks, Eric Burkhart, Jesse Kreye, Allyson Muth, Calvin Norman, Sanford Smith, Scott Weikert
Managed Online Panel Discussions As A Participatory Education Approach, Melissa M. Kreye, Kathryn Brooks, Eric Burkhart, Jesse Kreye, Allyson Muth, Calvin Norman, Sanford Smith, Scott Weikert
Journal of Extension
We assessed the social learning benefits provided by online panel discussions, where topics and questions on forestry issues were collected from the audience, but the discussions were limited to the people on the panel. We also examined the influence of different panelists including experts, extension professionals and peers. Findings indicate that the panels advanced understanding of issues, but also generated a variety of social benefits (e.g., validation, self-awareness, empathy, passion) that supported views about sustainable forestry and stewardship. Panels that involve peers and extension professionals were slightly better at generating a productive social learning environment, compared to panels containing experts.
Understanding Perceptions About And The Practice Of Integrated Pest Management And Biological Control Of The Filth-Breeding Flies By Individuals Involved In The Equine Industry In The United States, Virgillia Adele Beyer-Junfin, Theresa Pesl Murphrey, David Lawver, Barry Boyd, Amy Boren-Alpizar, Rilee Hall, Audra W. Richburg
Understanding Perceptions About And The Practice Of Integrated Pest Management And Biological Control Of The Filth-Breeding Flies By Individuals Involved In The Equine Industry In The United States, Virgillia Adele Beyer-Junfin, Theresa Pesl Murphrey, David Lawver, Barry Boyd, Amy Boren-Alpizar, Rilee Hall, Audra W. Richburg
Journal of Extension
Filth-breeding flies pose significant health risks and costs in the equine industry. Although an arsenal of management strategies exists, integrated pest management (IPM) utilizing biological control (BC) offers cost and labor efficient pest control for equine facilities. Yet, little data exists on IPM adoption across the equine industry in the United States. This quantitative study examines the knowledge, perceptions, and adoption of IPM of those involved in the equine industry. Findings reveal knowledge barriers and time constraints as major preventatives. Preferred communication channels for IPM information are also identified. Recommendations are made for further research and practice in IPM and …
Interpreting Extension Professionals' Viewpoints On Agricultural Climate Change Programming, Aaron B. Wilson, Alli Wenman, Samuel Pratsch, Kenneth Genskow, Patrick Robinson, Dennis Todey, Laurie Nowatzke, Namah Chiamo Taku-Forchu, Moses Wanyakha
Interpreting Extension Professionals' Viewpoints On Agricultural Climate Change Programming, Aaron B. Wilson, Alli Wenman, Samuel Pratsch, Kenneth Genskow, Patrick Robinson, Dennis Todey, Laurie Nowatzke, Namah Chiamo Taku-Forchu, Moses Wanyakha
Journal of Extension
We evaluated Extension professionals' attitudes and beliefs from Midwestern "1862" land-grant universities around three themes: prioritizing climate programming, farmers' perceptions, and the role of Extension leadership in building capacity to integrate climate change into programs. Using key informant interviews and a two-hour virtual workshop, we developed 'coordinate planes' to illustrate the tensions and contradictions among the three themes, with participants expressing highly diverse viewpoints across the region. Results identify the need for Extension leadership to support multi-state programs and shared resources that provide consistent guidance and expectations around climate change programming while recognizing the intrinsic state context and values.
The Land-Grant University’S Role In Lifelong Workforce Development In Food, Agriculture, And Natural Resources: Leveraging The Relationship Between Academic And Extension Programs, T. Grady Roberts, Debra M. Barry, J.C. Bunch, Suzanna Browning, Jason C. Dossett, R. G. (Tre) Easterly Iii, Cassandra Goff, Carla Jagger, Juan Montealegre, Brian E. Myers, Heather Nesbitt, Jason Steward, Jessica Switzer
The Land-Grant University’S Role In Lifelong Workforce Development In Food, Agriculture, And Natural Resources: Leveraging The Relationship Between Academic And Extension Programs, T. Grady Roberts, Debra M. Barry, J.C. Bunch, Suzanna Browning, Jason C. Dossett, R. G. (Tre) Easterly Iii, Cassandra Goff, Carla Jagger, Juan Montealegre, Brian E. Myers, Heather Nesbitt, Jason Steward, Jessica Switzer
Journal of Extension
Today’s food, agriculture, and natural resources (FANR) workforce is constantly evolving. Lifelong learning is no longer a lofty goal but is now a necessity. Colleges of agriculture at land-grant universities have the potential to meet the lifelong learning needs of the FANR workforce. In this article, we present a model where the academic and Extension components of colleges of agriculture at land-grant universities can link together to provide seamless lifelong workforce development. Our model is built on workforce development theory and is based on the traditions of the land-grant universities evolving to meet the needs of the people. Our model …
Farm Tour Evaluation Tool For Agricultural Awareness, Hannah Eason, Jessica Ryals, Yvette Goodiel, Lauren Butler, John Diaz, Marilyn Swisher
Farm Tour Evaluation Tool For Agricultural Awareness, Hannah Eason, Jessica Ryals, Yvette Goodiel, Lauren Butler, John Diaz, Marilyn Swisher
Journal of Extension
Educational farm tours offer learning opportunities that cannot be duplicated in a classroom setting. Developing a consistent farm tour evaluation tool is paramount to quantifying individual Extension farm tours while also providing a common platform to measure outcomes and impacts nationally and over time. An IRB-approved farm tour evaluation tool was developed to capture agricultural awareness and used to evaluate the 2022 National Association of County Agricultural Agents Annual Meeting/Professional Improvement Conference (NACAA AM/PIC) tours. The evaluation tool attempts to quantify farm tour outcomes and impacts and demonstrate the value of agriculture to decision makers, consumers, and community members.
Nebraska Extension Tractor And Equipment Safety Certification Course – Measuring Long-Term Impact And Implementing Improvements, Rebecca Bonacci, Ellen Duysen, Bri Parr, Susan Harris, Aaron Yoder
Nebraska Extension Tractor And Equipment Safety Certification Course – Measuring Long-Term Impact And Implementing Improvements, Rebecca Bonacci, Ellen Duysen, Bri Parr, Susan Harris, Aaron Yoder
Journal of Extension
Many jobs in agriculture have been deemed too hazardous for children younger than 16 years. A waiver allowing 14- and 15- year-old youth to work on farms requires safety course certification. [Redacted] Extension has partnered with a NIOSH funded Agricultural Safety Center to provide an annual tractor and equipment safety course across [Redacted]. To gauge impact, a survey addressed questions regarding the program's long-term impact, perceived value, injuries, close calls, recommendations for improvement and adoption and implementation of safety practices. The results have led to improved programming. The findings provide a roadmap to establish effective tractor and equipment certification programs.
Is There An Extension Discount For Agricultural Economics Faculty?, Siun Lee, Jeffrey Hyde, Yangxuan Liu, Rodolfo M. Nayga Jr, Wendong Zhang
Is There An Extension Discount For Agricultural Economics Faculty?, Siun Lee, Jeffrey Hyde, Yangxuan Liu, Rodolfo M. Nayga Jr, Wendong Zhang
Journal of Extension
Salary is an important aspect of one’s decision to pursue a particular career. This work compares the salaries of Agricultural Economics faculty members with and without Extension responsibilities across 19 departments in the US. We find that mean salaries for those with Extension appointments are significantly less than those without Extension appointments, ranging from a difference of $5,065 for assistant professors to $14,532 for full professors. We encourage administrators to acknowledge this “Extension Discount” and, if desired, make intentional decisions to reduce it. Doing so would serve to address recruiting challenges for Agricultural Economics Extension positions.
Effect Of Microbial Inoculation On Phosphate And Nitrogen Uptake From Dry Soil By Two Grasses With Different Nutrient Acquisition Strategies, Reem Hamdan Alkaabi
Effect Of Microbial Inoculation On Phosphate And Nitrogen Uptake From Dry Soil By Two Grasses With Different Nutrient Acquisition Strategies, Reem Hamdan Alkaabi
Thesis/ Dissertation Defenses
Organic matter and other sources of plant nutritional elements typically enter the soil from its surface, resulting in topsoil having the highest microbial activity, concentration of nutritional elements, and rooting densities. In agricultural systems of the UAE, high ambient temperature triggers rapid evaporation and causes the topsoil to dry. Nutrient uptake from dry soil is very challenging for plants, and topsoil dryness can have a negative impact on plant performance.
Beneficial soil microorganisms mediate plant growth by inducing tolerance against abiotic stresses. Arbuscular mycorrhizal (AM) fungi extend a large network of hyphae that helps the plants to acquire water and …
Nutritional Status And Endomycorrhizal Root Colonization Of Various Fruit Tree Species Grown In The Open Field In Al Ain, Uae, Mariam Mohammed Alhebsi
Nutritional Status And Endomycorrhizal Root Colonization Of Various Fruit Tree Species Grown In The Open Field In Al Ain, Uae, Mariam Mohammed Alhebsi
Thesis/ Dissertation Defenses
Domestic cultivation of fruits can greatly contribute to food security and supply of residents with healthy but highly perishable products. However, in the area of Al Ain, the cultivation of dicotyledonous fruit trees at the commercial scale is relatively uncommon, due to risks associated with the impact of the harsh environmental conditions on plant performance. The present study aimed at investigating to which extent mineral nutrient deficiency is responsible for the poor performance of fruit trees during the warm summer season. A five year old fruit tree plantation at the UAEU Research Farm in Al Foah served as study site. …
Introducing Neuro Social Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Introducing Neuro Social Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa
Social Work Faculty Publications
Neuroscience offers language and evidence that can strengthen interdisciplinary communication, support advocacy in biomedically dominated settings, and validate relational practices long recognized in social work, including the impacts of early adversity, attachment, and healing through connection. At the same time, an epistemological tension underlies the profession’s unease with neuroscience when brain-based narratives are used to individualize structural harm or justify surveillance of marginalized families and communities. This teaching note introduces Neuro Social Work as a justice-oriented specialization that integrates contemporary neuroscience with social work’s person-in-environment commitments, relational practice traditions, and anti-oppressive ethics.The author argues that the key question is no …
What A Landowner Should Expect When Hiring A Drone Aerial Applicator For Forestry Herbicide Application, Jon R. Carter, Patrick Hiesl, Jared A. Elmore, Nilesh Timilsina
What A Landowner Should Expect When Hiring A Drone Aerial Applicator For Forestry Herbicide Application, Jon R. Carter, Patrick Hiesl, Jared A. Elmore, Nilesh Timilsina
Forestry and Natural Resources
Chemical site preparation using herbicides is done primarily through three conventional methods: backpack sprayers, sprayers on forestry equipment, and helicopters/fixed-wing aircraft. However, in recent years, agricultural drones have been increasingly utilized to apply herbicides. While drones (unmanned aerial vehicles (UAV)) can perform common forestry tasks, meeting with the drone aerial applicator and collecting data for the herbicide application may look unfamiliar. This publication will help landowners and forestry professionals become more familiar with chemical site preparation and seedling releases applied by drones and what they should expect from start to finish from providers utilizing this technology.
Great Barracuda (Sphyraena Barracuda) Neurocranium, Preston J. Toutant, Tyler I. Anderson, Luke M. Mckeon, David W. Kerstetter
Great Barracuda (Sphyraena Barracuda) Neurocranium, Preston J. Toutant, Tyler I. Anderson, Luke M. Mckeon, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
Red Snapper (Lutjanus Campechanus) Neurocranium, Sophia Oliveira, Charlotte Gifford, David W. Kerstetter
Red Snapper (Lutjanus Campechanus) Neurocranium, Sophia Oliveira, Charlotte Gifford, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
The Impact Of Domed Architecture On The Architectural Character Of Western Desert Oases, Nader Mohamed Gharib, Mo’Men Abdelqader, Yousab Magdy Shafik
The Impact Of Domed Architecture On The Architectural Character Of Western Desert Oases, Nader Mohamed Gharib, Mo’Men Abdelqader, Yousab Magdy Shafik
Mansoura Engineering Journal
The visual disharmony arising from the indiscriminate and architecturally unplanned integration of curved roofing elements, notably domes, into the built environment of the Western Desert oases has become a significant issue, particularly in the Siwa Oasis, where the adoption of domed architecture was first introduced in the village of Jafar in 1997. This research delves into a detailed study that focuses on how pivotal historical, cultural, environmental, aesthetic, functional, and technical factors have crucially shaped the widespread integration of these iconic curved roofing superstructures in the oases' architectural heritage over generations, contributing to the uniquely recognizable architectural character and sense …
Allergenai: A Deep Learning Model Predicting Allergenicity Based On Protein Sequence, Jiajia Liu, Surendra S Negi, Chengyuan Yang, Xiaobo Zhou, Catherine H Schein, Werner Braun, Pora Kim
Allergenai: A Deep Learning Model Predicting Allergenicity Based On Protein Sequence, Jiajia Liu, Surendra S Negi, Chengyuan Yang, Xiaobo Zhou, Catherine H Schein, Werner Braun, Pora Kim
Faculty, Staff and Student Publications
BACKGROUND: Innovations in protein engineering offer promising solutions for redesigning allergenic proteins to minimize adverse reactions in sensitive individuals. Earlier models for predicting allergenicity have relied on the knowledge of physicochemical properties and sequence homology to assess the potential risk. However, to better understand the allergenic proteins’ sequence features, we need a novel sequence-based deep learning model for predicting allergenicity.
RESULTS: We present a novel AI-based tool, AllergenAI, to quantify the allergenic potential of a protein’s sequence without using any other known features. Our study utilized allergenic protein sequence data archived in the three well-established databases, SDAP 2.0, COMPARE, and …
Using Machine Learning For Early Prediction Of In-Hospital Mortality During Icu Admission In Liver Cancer Patients, Zhuo Zheng, Jinhong Xia, Jiawei Luo, Lei Du, Xiaobo Zhou, Xiaoyan Yang, Yan Xia, Mengyao Liu, Shixin Huang
Using Machine Learning For Early Prediction Of In-Hospital Mortality During Icu Admission In Liver Cancer Patients, Zhuo Zheng, Jinhong Xia, Jiawei Luo, Lei Du, Xiaobo Zhou, Xiaoyan Yang, Yan Xia, Mengyao Liu, Shixin Huang
Faculty, Staff and Student Publications
Liver cancer has a high incidence and mortality rate globally, particularly in patients requiring intensive care unit (ICU) admission. Early prediction of in-hospital mortality for these patients is crucial, yet lacking reliable tools. This study aims to develop and evaluate machine learning (ML) models for predicting in-hospital mortality in critically ill liver cancer patients admitted to the ICU. This retrospective study used data from the MIMIC-III and MIMIC-IV databases, including 862 patients from MIMIC-III (training cohort) and 692 patients from MIMIC-IV (validation cohort). The study focused on patients diagnosed with liver cancer, identified by specific ICD codes. Four ML algorithms, …
Insights Into The Relevance Of Targeting Fibroblasts To Control Cancer, Viktoria Boeker, Raghu Kalluri
Insights Into The Relevance Of Targeting Fibroblasts To Control Cancer, Viktoria Boeker, Raghu Kalluri
Faculty, Staff and Student Publications
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) have garnered significant research attention in the last decade. As key stromal cells of the TME, studies have explored them as a potential target for controlling cancer. Using high-throughput technologies like single-cell RNA sequencing coupled with proteomics, the classification of different CAF subgroups reveals a complex system that varies by cancer type. Unraveling novel big data, potentially through AI platforms, will be key to identifying the role of CAFs in tumor progression and therapy escape mechanisms, enabling new therapies that manipulate CAFs to increase patients' survival. We summarize and discuss new developments …
Prognosis And Treatment Response Stratification According To Loss Of Proofreading (Lop), Giulia Maddalena, Fadl A Zeineddine, Saikat Chowdhury, Mohammad A Zeineddine, Abdelrahman M Yousef, Francesca Bergamo, Sara Lonardi, Timothy A Yap, Michael Geoffrey White, Michael J Overman, Scott Kopetz, John Paul Shen
Prognosis And Treatment Response Stratification According To Loss Of Proofreading (Lop), Giulia Maddalena, Fadl A Zeineddine, Saikat Chowdhury, Mohammad A Zeineddine, Abdelrahman M Yousef, Francesca Bergamo, Sara Lonardi, Timothy A Yap, Michael Geoffrey White, Michael J Overman, Scott Kopetz, John Paul Shen
Faculty, Staff and Student Publications
Background: Only a subset of polymerase epsilon (POLE) mutations is associated with hypermutant phenotype; we hypothesized that only loss-of-proofreading (LOP) POLE mutations are associated with favorable immunotherapy response.
Methods: This retrospective cohort study included a pan-cancer cohort of 69,223 patients from cBioPortal and a cohort of patients with 41 POLE mutant metastatic colorectal (CRC) treated with immunotherapy at the MD Anderson Cancer Center between January 2017 and May 2023. We evaluated prognosis according to POLE mutation functionality.
Results: In the pan-cancer cBioPortal cohort (n=69,223) POLE was mutated in 2.8% (1,965) of tumors; of these, only 7.5% (n=148) had …
Voices: Future Directions In Targeting The Tumor Microenvironment, Tanja De Gruijl, Catherine Sautès-Fridman, Daniela S Thommen, Michael A Curran
Voices: Future Directions In Targeting The Tumor Microenvironment, Tanja De Gruijl, Catherine Sautès-Fridman, Daniela S Thommen, Michael A Curran
Faculty, Staff and Student Publications
What do you envision as the most promising future directions for therapeutic strategies aimed at modulating the tumor microenvironment?
Identification Of Therapeutic Targets For Renal Medullary Carcinoma Via Integrated Genomic And Transcriptomic Profiling, Pavlos Msaouel, Nizar M Tannir, Funda Meric-Bernstam, Jennifer M King, Martin H Voss, Jessica P Cheng, Susan S Thomas, Zita D Lim, Menuka Karki, Rong He, Giannicola Genovese, Rahul A Sheth, Davis R Ingram, Diana Shamsutdinova, Khalida M Wani, Wei-Lien Wang, Alexander J Lazar, Dominique Knipper-Davis, Amber Berlinski, Tayla Soares, Danil Stupichev, Kirill Kryukov, Suren Davitavyan, Anna Novokreshchenova, Dmitry Lebedev, Stanislav Kurpe, Andrey Kravets, Dmitrii Belousov, Michael Hensley, Alexander Bagaev, Francesca Paradiso, Vladimir Kushnarev
Identification Of Therapeutic Targets For Renal Medullary Carcinoma Via Integrated Genomic And Transcriptomic Profiling, Pavlos Msaouel, Nizar M Tannir, Funda Meric-Bernstam, Jennifer M King, Martin H Voss, Jessica P Cheng, Susan S Thomas, Zita D Lim, Menuka Karki, Rong He, Giannicola Genovese, Rahul A Sheth, Davis R Ingram, Diana Shamsutdinova, Khalida M Wani, Wei-Lien Wang, Alexander J Lazar, Dominique Knipper-Davis, Amber Berlinski, Tayla Soares, Danil Stupichev, Kirill Kryukov, Suren Davitavyan, Anna Novokreshchenova, Dmitry Lebedev, Stanislav Kurpe, Andrey Kravets, Dmitrii Belousov, Michael Hensley, Alexander Bagaev, Francesca Paradiso, Vladimir Kushnarev
Faculty, Staff and Student Publications
Renal medullary carcinoma (RMC) is a rare but highly aggressive kidney cancer that resists conventional therapies. To identify therapeutic targets, this study employs histopathologic, genomic, and transcriptomic profiling of 25 RMC samples. TROP2, EPCAM, CLDN6, and CDH6 are significantly overexpressed compared with other renal and solid tumors. Pathway analyses indicate Hippo pathway upregulation and a tumor microenvironment rich in fibroblasts and neutrophils. We subsequently explore treatment of four heavily pretreated patients, all with high TROP2 expression, using sacituzumab govitecan, a TROP2-targeted antibody-drug conjugate. Of these four patients, one patient achieves a partial response with symptom improvement, two patients maintain stable …
Effects Of Photo-Oxidized Crude Oil On Gulf Killifish Early Life Stages, Charles Campbell
Effects Of Photo-Oxidized Crude Oil On Gulf Killifish Early Life Stages, Charles Campbell
LSU Master's Theses
Photo-oxidation of spilled crude oil generates polar compounds that can heighten toxicity to marine fish embryos. We investigated the effects of photo-oxidized crude oil on early life stages of Gulf killifish (Fundulus grandis) by exposing embryos under flow-through conditions to water-accommodated fractions of four oil treatments: fresh oil unexposed to either sunlight or weathering referred to as dark control (DC), a UV-light oxidized whole oil (LT), the polar fraction extracted from LT (Pol) and the remnants after extracting the Pol from LT (NP). Oil loadings of 0.38–3.00 g oil/kg water were tested. Total PAH concentrations and chemical profiles …
Indigenous And Tribal Nation Scientists And Universities, Elizabeth A. Sumida Huaman, Stephen J. Smith
Indigenous And Tribal Nation Scientists And Universities, Elizabeth A. Sumida Huaman, Stephen J. Smith
Critical Internationalization Studies Review
No abstract provided.
Interview With Orca Award Winner James Van Etten, Unl Plant Pathology; Discoverer Of Giant Viruses, Mark Griep, James Van Etten
Interview With Orca Award Winner James Van Etten, Unl Plant Pathology; Discoverer Of Giant Viruses, Mark Griep, James Van Etten
UNL ORCA Interview Series
Dr. James Van Etten was awarded the UNL Outstanding Research and Creative Activities Award in 1992. He was born in Virginia but grew up Peoria, Illinois. Something in his youth must have sparked an interest in science because he earned his bachelor’s degree in biology from Carleton College in 1960. Carleton is a well-regarded liberal arts institution in Northfield, Minn., about 400 miles from Peoria. Next, Jim earned a master’s and doctorate at the University of Illinois in Champaign-Urbana, both in plant pathology. For his postdoctoral work in 1965 and 1966, he did postdoctoral work in the Department of Genetics …
European Seabass (Dicentrarchus Labrax) Neurocranium, Gianna Dib, Logan A. Murphy, Esmeralda Orozco, David W. Kerstetter
European Seabass (Dicentrarchus Labrax) Neurocranium, Gianna Dib, Logan A. Murphy, Esmeralda Orozco, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
Coryphaena Hippurus (Mahi-Mahi) Neurocranium, Victoria E. Acosta, Margaret L. Mantineo, Sienna Lazar, Loren Hart, David W. Kerstetter
Coryphaena Hippurus (Mahi-Mahi) Neurocranium, Victoria E. Acosta, Margaret L. Mantineo, Sienna Lazar, Loren Hart, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
Citronellol Reduces Sepsis-Induced Renal Inflammation Via Ap-1/Nf-Κb/Tnf-Α Pathway, Huda Rashid Atiyah, Sarmed H. Kathem, Surya M. Nauli
Citronellol Reduces Sepsis-Induced Renal Inflammation Via Ap-1/Nf-Κb/Tnf-Α Pathway, Huda Rashid Atiyah, Sarmed H. Kathem, Surya M. Nauli
Pharmacy Faculty Articles and Research
Sepsis is characterized by the over-production of pro-inflammatory cytokines. Cecal ligation and puncture (CLP) is a well-accepted model for recreating sepsis-induced renal injury in mice. The current study investigates how citronellol, a naturally occurring substance with a variety of biological characteristics, can prevent acute kidney inflammation brought on by CLP. In the CLP mouse model, citronellol was administered orally at doses of 50 and 100 mg/kg. Serum levels of creatinine and urea were used as markers of renal function, and the Murine Sepsis Score (MSS) was used to assess the severity of sepsis. According to our findings, CLP caused a …
11.17.2025 Ored Connect, Liz Williamson
11.17.2025 Ored Connect, Liz Williamson
ORED Newsletter
- Qualtrics training sessions
- Alcorn State University, Dr. Edmund Buckner
Autostent: A Semi-Automated Approach To Designing Customized 3d-Printed Oral Radiation Stents For Patients With Head And Neck Cancer, Anshuman Agrawal, Rance B Tino, Mohamed Zaid, Millicent Roach, Lianchun Xiao, Mark S Chambers, Anna Lee, Eugene J Koay
Autostent: A Semi-Automated Approach To Designing Customized 3d-Printed Oral Radiation Stents For Patients With Head And Neck Cancer, Anshuman Agrawal, Rance B Tino, Mohamed Zaid, Millicent Roach, Lianchun Xiao, Mark S Chambers, Anna Lee, Eugene J Koay
Faculty, Staff and Student Publications
Background: Oral stents may reduce toxicities during radiation therapy for head and neck cancer (HNC). Customized 3D-printed oral stents offer faster production and achieve comparable patient-reported outcomes to conventionally fabricated stents. However, their design process remains time-consuming, lacks standardization, and relies heavily on skilled technicians. We hypothesized that semi-automating the design process for 3D-printed, mouth-opening, tongue-depressing (MOTD) stents could standardize the design workflow and decrease design time.
Methods: Using oral stent design principles established over decades by oral oncologists, we created a customized computer program (Autostent) using MATLAB to semi-automate the design process of MOTD stents. We subsequently compared Autostent …
Multiomic Analysis Reveals A Key Bcat1 Role In Mtor Activation By B Cell Receptor And Tlr9, Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Rahaman A Ahmed, Weixing Li, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicholas A Smith, Meng Li, Merrin Man Long Leong, Michael Lutchenkov, Jin Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael R Green, John M Asara, Adonia E Papathanassiu, Duane R Wesemann, Steven P Gygi, Vamsi K Mootha, Benjamin E Gewurz
Multiomic Analysis Reveals A Key Bcat1 Role In Mtor Activation By B Cell Receptor And Tlr9, Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Rahaman A Ahmed, Weixing Li, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicholas A Smith, Meng Li, Merrin Man Long Leong, Michael Lutchenkov, Jin Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael R Green, John M Asara, Adonia E Papathanassiu, Duane R Wesemann, Steven P Gygi, Vamsi K Mootha, Benjamin E Gewurz
Faculty, Staff and Student Publications
B lymphocytes play major adaptive immune roles, producing antibodies and driving T cell responses. However, how immunometabolism networks support B cell activation and differentiation in response to distinct receptor stimuli remains incompletely understood. To gain insights, we systematically investigated acute primary human B cell transcriptional, translational, and metabolomic responses to B cell receptor (BCR), TLR9, CD40-ligand (CD40L), IL-4, or combinations thereof. T cell-independent BCR/TLR9 costimulation, which drives malignant and autoimmune B cell states, highly induced transaminase branched chain amino acid transaminase 1 (BCAT1), which localized to lysosomal membranes to support branched chain amino acid synthesis and mTORC1 activation. BCAT1 inhibition …