Digital Commons Network^™

The Fitness Cost Of Rifampicin-Resistant Rpob Mutations On Mfd-Mediated Processes In Stationary Phase Bacillus Subtilis, Amber Callaway, Jessica Grifaldo

Undergraduate Research Symposium Posters

Rifampicin is a potent antibiotic that tightly binds to the ꞵ-subunit of RNA polymerase and blocks initiation of transcription. Bacillus subtilis cells that acquire rpoB mutations that confer resistance to rifampicin also exhibit decreases in transcription and fitness. Mutation frequency decline (Mfd) is a global transcription regulator that interacts with the ꞵ-subunit of RNA polymerase, and our RNA-seq showed that it had profound effects on the expression of motility genes. We hypothesize that the rifampicin-resistant rpoB: I681T mutation alters Mfd-mediated gene regulation of motility in Bacillus subtilis. Therefore, we will construct mfd- rpoB: I681T double mutants via natural competence and …

Dorsal/Ventral Orientation Of Dentate Granule Cells And Its Impact On Electrophysiology In Mice, Jacob Prince, Savannah Sampson, Alyssa Marron

Undergraduate Research Symposium Posters

The hippocampus has known roles in memory formation, learning, and spatial mapping. There are defined physiological differences between CA1 neurons based on their dorsal to ventral position within the 3D hippocampus (Malik et al., 2015). Given the varying functions of the dorsal and ventral hippocampus in cognitive processing and the role of the dentate gyrus as the entry point for information into the hippocampus, it will be interesting to determine if there are differences in the properties of granule cells across the dorsal and ventral axis. We explore the potential topographic specialization of dentate granule cells. This study examines the …

Associations Between Gad-7 And Phq-9 Scores And Willingness To Seek Treatment, Josephine Shaw

Undergraduate Research Symposium Posters

In recent years, mental health concerns among college students have increased significantly. This study aims to analyze data on student willingness and frequency to seek counseling services, such as UNLV CAPS (Student Counseling and Psychological Services), and the appeal of utilizing alternative interventions such as exercise and meditation. This study collected data from UNLV students, faculty, and staff through distribution of a scannable QR code. It included whether they were in therapy, the PHQ-9 and GAD-7, their respective functional impairment questions, and willingness to consider therapy alternatives. Based on respondents’ answers to the PHQ-9, the highest proportion peaked at 36% …

Hawaiian Drosophila Host Plant Preferences, Kyrus Huang, Rodomir Stark

Undergraduate Research Symposium Posters

Understanding how host plant availability influences behavior in Drosophila species provides valuable insight into ecological specialization and speciation. This study examines the effects of different host plants on the reproductive and oviposition behavior of Drosophila silvestris and Drosophila grimshawi. The primary objective of this project is to determine whether females exhibit host-plant preferences during egg-laying. A secondary aim is to assess whether sex and mating status influence host plant preference, specifically comparing male, unmated female, and mated female behavior with two host plants. To test these hypotheses, newly emerged flies were divided into three treatment groups: male-only, female-only, and mixed …

Assessing How Early Vs. Late Exercise Influences Whole Body Glucose Tolerance And Insulin Signaling Pathways In Quadriceps During Social Jetlag, Ariana Khzarjyan, Austin Cooper, Paula Martinez, Joshua Corpuz, Srushti Wagh, Elias Malek, Todd Schrubb

Undergraduate Research Symposium Posters

BACKGROUND: Circadian rhythms regulate our physiological and metabolic processes throughout a 24-hour cycle. Disruptions to this rhythm with modern lifestyles creates irregular patterns. One of the most common forms of circadian rhythm disruptions amongst humans happens during the weekends, when people tend to stay up later and sleep in later compared to weekdays. This phenomenon is referred to as social jetlag (SJL).

PURPOSE: To determine whether timed exercise (early vs. late) can reduce the negative effects of social jetlag in mice. More specifically, determining whether exercise conducted in the early or late active phase of mice will impact the effects …

Integrative Profiling Strategies To Guide Personalized Therapy In Mantle Cell Lymphoma: A Pilot Study, Yang Liu, Holly A Hill, Yijing Li, Joseph Mcintosh, Vivian Jiang, Fangfang Yan, Yixin Yao, Yue Fei, Jared Zhang, Lawrence Qu, Jun Yao, Preetesh Jain, Ken Chen, Michael Wang

Faculty, Staff and Student Publications

Mantle cell lymphoma (MCL) responds to frontline therapy but is susceptible to relapse. While Bruton's tyrosine kinase inhibitors (BTKi) achieve high response rates, most patients eventually experience disease progression. Predicting responses to subsequent treatments remains challenging due to the lack of an established platform. Heterogeneity in gene alterations and cellular pathways contribute to resistance, complicating treatment approaches. Here, we present a multi-modal profiling platform, targeting key pathways rather than focusing on singular DNA-associated lesions. We identified dysregulated signaling pathways by performing gene expression profiling on 20 MCL samples using a custom MCL MATCH gene set and analyzed the data with …

Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L Palaskas, Kevin T Nead, Venkata S K Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune modulation, in tumor development and vascular homeostasis. SHP2 conveys PD-1 mediated inhibitory signaling in T cells, and is emerging as a therapeutic target. Importantly, there is an association between immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs), and cardiovascular complications, underscoring the need to understand SHP2’s role in these processes. This review aims to summarize current knowledge on SHP2/PTPN11 biology, its role in immune …

Valorization Of Rice Bran For Functional Bioplastic Fabrication Using Plasma-Activated Water, Saydul Md Safwa, Muhammad Nazrul Islam, Keisha B. Walters, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

While plasma has been used for decades for the surface modification of packaging films, in this study, rice bran (RB) and rice bran protein (RBP) films were developed using plasma-activated water (PAW), and the chemical composition, surface structure modifications, surface properties, and thermal properties of these films were characterized. Fourier-transform infrared spectroscopy (FTIR) of the bran and protein films showed that the reactive species in PAW improved hydrogen bonding, as evidenced by the increase in the O-H stretching band at 3300 cm-1 and reduced peak intensity at 2940-2925 cm-1 (C-H stretching), suggesting oxidation of the aliphatic side chains. For the …

Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries. It is caused by pathogenic variants in ABCC6 , which encodes a transmembrane transporter that primarily localizes to hepatocytes. Loss of ABCC6 function in hepatocytes leads to systemic deficiency of inorganic pyrophosphate (PPi), a potent inhibitor of calcification; such depletion of PPi from the circulation is responsible for multisystemic ectopic calcification seen in PXE. Therefore, liver-targeted variant correction by genome editing and subsequent restoration of systemic PPi may offer a one-and-done therapeutic approach for PXE. The ABCC6 …

First Report Of A Bat Guano Fire From A Cave In Southeast Asia, Sopark Jantarit, Martin Ellis, Pruet Kalasuwan, Neeranuch Phusunti, Pimonsri Mittraparp-Arthorn, Jiranan Pattano, Arnon Chukamnerd, Turdtun Tong-In, Natthawut Khrueaaunruean

International Journal of Speleology

Fires occurring in cave guano are a rare and unusual phenomenon and the occurrence of such events in Southeast Asia is particularly novel. In this study, we document the first recorded instance of a bat guano fire in a tropical cave at Tham Chao Ram in Sukhothai province, northern Thailand. A bacteriological analysis was made of the guano at the fire site and from a control site within the cave. We give a comprehensive review of global reports on bat guano fires in caves, conduct an initial investigation of the physical factors at the fire site and discuss the potential …

Novel Eco-Friendly Synthesis Of Coo Nps: Evaluation Of Their Diode Laser-Enhanced Inhibitory Activity Through Combined In Silico And In Vitro Approaches., Arshad Mahdi Hamad, Sahar Naji Rashid

Karbala International Journal of Modern Science

In our study, for the first time worldwide, to the best of our knowledge, cobalt oxide nanoparticles (CoO NPs) were synthesized using naringin (Nar) extracted from citrus peels. The properties of the prepared Nar-CoO NPs were studied using field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), ultraviolet-visible (UV-Vis), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy. All the test results demonstrated the efficiency and success of the nanofabrication process. The solution was then exposed to three types of diode lasers: red (650 nm), green (532 nm), and blue (405 nm). The purpose of this study was …

Gdf15 Is A Putative Biomarker For Distinguishing Pulmonary Veno-Occlusive Disease And Pulmonary Arterial Hypertension, Amit Prabhakar, Eckart De Bie, Jacqueline T. Desjardin, Prajakta Ghatpande, Stefan Gräf, Luke S. Howard, S. John Wort, Colin Church, David G. Kiely, Uk Pulmonary Arterial Hypertension Cohort Study Consortium, Emily Sumpena, Thin Aung, Shenrae Carter, Jasleen Kukreja, Steven Hays, John R. Greenland, Jonathan P. Singer, Michael Wax, Paul J. Wolters, Marc A. Simon, Mark Toshner, Giorgio Lagna, Akiko Hata

Biology

To the Editor: Pulmonary veno-occlusive disease (PVOD) is a rare, severe group 1 pulmonary arterial hypertension (PAH) subtype with poor survival (1). PAH-targeted vasodilators can cause life-threatening pulmonary edema in PVOD, underscoring the need for diagnostic tools to distinguish it from other PAH subtypes (1). In patients and mitomycin C–induced (MMC-induced) model animals, aberrant activation of integrated stress response (ISR) via protein kinase R (PKR) drives cardiovascular phenotypes of PVOD (2–4). Inhibition of the PKR-ISR axis, using either the PKR inhibitor C16 or the ISR inhibitor ISRIB, reverses PVOD phenotypes (2–4). Because GDF15 is a cytokine induced by the ISR …

The Role Of Nutrition-Sensitive Interventions In Improving Nutritional Outcomes: Findings From A Systematic Review And Meta-Analysis, Thomas De Hoop, Adria Molotsky, Rebecca Walcott, Pablo Gaitán-Rossi, Sonia Hernández-Cordero, Amos Laar, Torben Behmer, Hoa Thi Mai Nguyen, Averi Chakrabarti, Garima Siwach, Varsha Ranjit, Vania Lara-Mejía, Bianca Franco-Lares, Mireya Vilar-Compte

Department of Nutrition and Food Studies Scholarship and Creative Works

Background

Maternal and child undernutrition remains a major global health concern despite modest progress. Accelerating reductions in stunting and wasting will require increased investments in nutrition-sensitive interventions, which target nutrition impacts outside of the healthcare setting. This review examines the effects of four types of nutrition-sensitive interventions —cash/food transfers, nutrition-sensitive agriculture, water/sanitation/hygiene, and school nutrition— on maternal and child nutrition outcomes and dietary diversity.

Methods

We synthesized the evidence using an initial broad search and synthesis for nutrition-sensitive interventions, followed by targeted searches and syntheses for specific interventions and nutrition outcomes. Meta-analyses were performed to evaluate the impacts of cash …

Mahi Mahi (Coryphaena Hippurus) Neurocranium, Ameer Tolani, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Navigating Structure, Function, And Stability: Bridging Immunotherapy And Protein Engineering In The Era Of Machine Learning, Christopher J. Haynie

Theses and Dissertations

The immune system is a remarkably adaptive network, yet it often fails to function optimally due to evasion strategies of pathogens or mutated cells. Many of these evasion strategies involve alterations in protein expression and function. Protein design is an area of computational biology with potential applications in improving protein function and therapeutic protein engineering. This thesis explores methods to enhance immune function and protein design across multiple scales, from molecular engineering of antibody fragments and chimeric antigen receptors (CARs) to cellular immune responses, and computational approaches for protein structure optimization. We characterize Thymidine Kinase 1-specific single-chain antibodies, highlighting both …

Evaluation Of Nine Sh2 Sweet Corn Cultivars In Southwest Michigan In 2025, Ben Phillips

Midwest Vegetable Trial Reports

A bicolor sh2 sweet corn cultivar trial was planted at the Southwest Michigan Research and Extension Center (42.081985, -86.354087, Benton Harbor, Michigan). Seeds were donated by Crookham (CK), and Rupp (RP) seed companies. Two synergistic varieties were donated by Chris Difonzo from the Bt resistance project and were treated as unsprayed late-season checks against caterpillar infestation. Overall trial conditions were hot and dry, with moisture stress throughout the trial on a sandy hill. Overhead irrigation provided some relief. A new seeder was used that planted at a lower population than desired. As such, yield suffered in this trial.

Evaluation Of Six Roma Tomato Cultivars In Southwest Michigan In 2025, Ben Phillips

Midwest Vegetable Trial Reports

A Roma tomato cultivar trial was planted at the Southwest Michigan Research and Extension Center (42.081985, -86.354087, Benton Harbor, Michigan). HM Clause (HM), Lark (LK), and Sakata (SK) seed companies donated 6 cultivars for plastic mulch-bedded hand harvest. Overall, the trial quality was good, with periods of high heat slowing ripening.

Genome-Wide Association Study Of 398,238 Women Unveils Seven Loci Associated With High-Grade Serous Ovarian Cancer, Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington De Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel De La Hoya, Anna Defazio, Allison Depersia, Yuan Chun Ding, Jennifer A Doherty, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A Mcneish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Yen Y Tan, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah

Faculty, Staff and Student Publications

Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta-analyzed >22 million variants for 398,238 women from the Ovarian Cancer Association Consortium (OCAC), UK Biobank (UKBB) and Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) to identify novel HGSOC susceptibility loci. Eight novel variants were associated with HGSOC risk. An interesting discovery biologically was TP53 3’-UTR SNP rs78378222-T’s association with HGSOC (per-T-allele relative risk (RR) = 1.44, 95% CI:1.28–1.62, P = 1.76 × 10−9). Polygenic scores (PGS) were developed using OCAC and CIMBA data and trained on FinnGen data. The optimal PGS included 64,518 …

Acute Myeloid Leukemia With T(10; 17)(P15; Q21)/ Zmynd11::Mbtd1: A Subtype With Minimal Differentiation, Cd7/Cd56 Expression, And Generally Poor Outcomes In Adults, Qing Wei, Naveen Pemmaraju, Sa A Wang, Shimin Hu, Courtney Dinardo, Ghayas C Issa, Carlos E Bueso-Ramos, Jie Xu, Shaoying Li, Jeffrey L Medeiros, Guilin Tang

Faculty, Staff and Student Publications

No abstract provided.

Five-Year Follow-Up Analysis Of Zuma-5: Axicabtagene Ciloleucel In Relapsed/Refractory Indolent Non-Hodgkin Lymphoma, Sattva S Neelapu, Julio C Chavez, Alison R Sehgal, Narendranath Epperla, Matthew L Ulrickson, Emmanuel Bachy, Pashna N Munshi, Carla Casulo, David G Maloney, Sven De Vos, Ran Reshef, Lori A Leslie, Olalekan O Oluwole, Ibrahim Yakoub-Agha, Rashmi Khanal, Joseph D Rosenblatt, Jacob Wulff, Rhine R Shen, Wangshu Zhang, Soumya Poddar, Harry Miao, Olga Nikolajeva, Caron A Jacobson

Faculty, Staff and Student Publications

Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory (R/R) follicular lymphoma (FL). Here, we report updated clinical outcomes from ZUMA-5 in 159 enrolled patients with R/R indolent non-Hodgkin lymphoma (iNHL; 127 with FL and 31 with marginal zone lymphoma) after a median follow-up of 64.6 months. Patients underwent leukapheresis and received lymphodepleting chemotherapy and axi-cel (2 × 106 CAR T cells/kg). The overall response rate was 90% (75% complete response rate). The median duration of response was 60.4 months, and the median progression-free survival (PFS) was 62.2 months; median time to next …

Early Tumor Volume Reduction By Breast Dce Mri Predicts Pathologic Complete Response To Neoadjuvant Therapy In Triple Negative Breast Cancer, Mary S Guirguis, Beatriz E Adrada, Clinton Yam, Debu Tripathy, Rosalind Candelaria, Wei Yang, Miral Patel, Tanya Moseley, Frances Perez, Gary J Whitman, Jessica W T Leung, Huong Le-Petross, Deanna L Lane, Lei Huo, Jennifer K Litton, Vicente Valero, Kelly K Hunt, Banu Arun, Rania Mohamed, Jia Sun, Anil Korkut, Zhan Xu, Sanaz Pashapoor, Jason White, Jong Bum Son, Alastair Thompson, Peng Wei, Jingfei Ma, Stacy Moulder, Gaiane M Rauch

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is a heterogeneous disease with variable response to neoadjuvant systemic therapy (NAST). Patients with pathologic complete response (pCR) following NAST have improved survival. Our goal was to establish readily accessible imaging biomarker to identify which TNBC patients will have pCR. Building on prior favorable results in the literature, we hypothesized that manually measured tumor volume changes at DCE-MRI may predict pCR early during NAST. This prospective study included 287 stage I-III TNBC patients who underwent DCE-MRI at baseline, after two and four cycles of NAST, with pCR accessed at surgery (NCT02276443). Tumor volume and percentage tumor …

Vermicomposting, Hayley Waldbillig, Roslynn Brain, Scott Kent, Roslynn Brain Mccann

All Current Publications

Vermicomposting, or worm composting as it is more commonly known, is the process of using worms to break down discarded food and other organic wastes and convert them into compost and liquid fertilizers.

Evaluating Policy And Industry-Based Interventions For Healthier Online Food-Away-From-Home Choices: A Scoping Review, Vincenzina Caputo, Jiayu Sun, Ellen J. Van Loo

Department of Agricultural Economics Faculty Publications

The rapid digital transformation of the food-away-from-home (FAFH) sector has redefined how consumers access and select meals. Digital delivery platforms such as Uber Eats, Deliveroo, and Meituan have become influential market intermediaries, shaping the nutritional landscape of food environments and raising concerns about their healthfulness. This study reviews empirical evidence on policy-based and industry-led interventions aimed at improving dietary outcomes in digital FAFH environments. Following PRISMA guidelines and using machine-learning–assisted screening (ASReview), 37 peer-reviewed studies were identified across four domains: nutritional labeling, fiscal measures, food-assistance programs, and digital nudges or decision-support tools. Findings indicate that although traditional food-policy instruments designed …

Tca Cycle Mode Switch Determines The Fate Of Pirtobrutinib-Tolerant Persister Cells In Mantle Cell Lymphoma, Wei Wang, Qingsong Cai, Yang Liu, Lei Nie, Heng-Huan Lee, Fangfang Yan, Yue Fei, Yixin Yao, Yijing Li, Lin Tan, Philip L Lorenzi, Ying-Nai Wang, Jun Yao, Zhihong Chen, Joseph Mitchell Mcintosh, Cheng-Tai Yu, Preetesh Jain, Vivian C Jiang, Jovanny Vargas, Xiaolin Li, Tianci Zhang, Shaoying Li, David Santos, Selvi Thirumurthi, Erin Heather Seeley, Lukas Mikolaj Simon, Christopher Flowers, Chi Young Ok, Michael Wang

Faculty, Staff and Student Publications

Bruton tyrosine kinase inhibitors (BTKis) and cell therapy have successfully been used to treat mantle cell lymphoma (MCL). However, therapy resistance inevitably emerges. Cancer cells can progressively develop stable resistance by traversing through a transient drug-tolerant persister (DTP) state. The mechanisms enabling DTP cells to reversibly adapt to therapies and evolve to acquire heterogeneity remain poorly understood, and characterizing DTP cells in MCL continues to pose a challenge for clinic translation. Here, using pirtobrutinib, a recently US Food and Drug Administration-approved noncovalent BTKi, we identified pirtobrutinib-tolerant persister cells exhibiting morphological variability by presenting a unique population of enlarged cells (giant …

Can Motivation And Self-Efficacy Predict A Law Enforcement Officer’S General And Job-Specific Fitness?, Robert G. Lockie, Maria M. Beitzel, Tyler Campana, Jennifer Kramer, Robin (Rob) Marc Orr, J. Jay Dawes, Joseph Dulla

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1393-1409, 2025. https://doi.org/10.70252/GEHB5425 Sedentary behaviors contribute to law enforcement officer fitness declines over a career. An officer’s motivation (desire to exercise) and self-efficacy (belief in ability to exercise) could affect whether they exercise and predict resulting fitness. Data from 60 officers (48 men, 12 women) were analyzed. Motivation (amotivation, external, introjected, identified, integrated, and intrinsic regulation) was measured via the Behavioral Regulation in Exercise Questionnaire. A 6-item questionnaire assessed coping (confidence in exercising under challenging conditions) and scheduling (confidence in scheduling exercise) self-efficacy. General fitness variables included sit-and-reach, grip strength, 60-s push-ups, 60-s sit-ups, …

Designing And Writing Effective Data Management Plans For Grant Proposals, Rubab Shahzad, Ibis Anette Moreno-Lozano

Day Family Research Lab Workshop Series

Fundamentals of research data management and how to create effective Data Management Plans (DMPs).

Ladyfish (Elops Saurus) Neurocranium, Kaylee M. Blanchard, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Prediction Model Of Storage Quality Change And Shelf Life Of Dried Pork Slice, Chen Xiaohe, Qian Ping, Huang Ning, Yang Ran, Qu Lingbo, Zhao Changcheng, Li Chunxia

Food and Machinery

[Objective] To investigate the quality changes of dried pork slices under different temperature storage conditions and to predict their shelf life. [Methods] Hardness, color parameters (L* value, a* value, b* value ), and sensory quality of dried pork slices were investigated under storage at 25, 35, 45, and 55℃. Pearson correlation analysis was performed for each index, and the key index was fitted using a dynamic model. Combining the Arrhenius equation with the Q10 model, a shelf life prediction model was established. [Results] Under storage at 25, 35, 45, and 55 ℃, the a* value of dried pork slices decreased …

Optimization Of Bioethanol From Plantain Peel Using Saccharomyces Cerevisiae, Akinjide A. Akinola, Olawole O. Olanipekun, Paul A. David

Mansoura Engineering Journal

This research aimed to evaluate the potential of using plantain peels as a raw material for producing bioethanol with the help of Saccharomyces cerevisiae. The study utilized a four-factor Box-Behnken design (BBD) and response surface methodology (RSM) to optimize the fermentation conditions. The factors considered for optimization were substrate concentration (1-4 g), pH (5-7), temperature (30-45°C), and fermentation time (24-96 hours). Through this optimization process, the study found that the optimal conditions for bioethanol production were 4 g substrate concentration, pH 6, 45°C temperature, and 60 hours of fermentation time. Utilizing these optimal conditions resulted in a bioethanol yield of …

Conjunctival Melanoma Genomic Analysis Reveals Intermediate Tumor Mutation Burden And Genomic Overlap With Cutaneous Melanoma, Florentia Dimitriou, Xiaogang Wu, Priyadharsini Nagarajan, Isabella C Glitza, Li Zhao, Jing Ning, Sapna P Patel, Jennifer A Wargo, Andrew Futreal, Scott Woodman, Jennifer L Mcquade, Bita Esmaeli

Faculty, Staff and Student Publications

Conjunctival melanoma (CJM) is a rare and aggressive malignancy. Mainly attributed to its rarity, the genomic features of CJM have not been well characterized. In the present study, we sequenced the exomes of primary and metastatic CJM tumors with the aim to unravel their genomic landscape. The results of the study suggest that CJM is a molecularly distinct melanoma subtype with mixed genotype and targetable mutations. Notably, there were features overlapping with both mucosal, and mainly cutaneous melanoma. Of note, some genetic alterations were found in association with specific subsets of CJM, such as bulbar anatomical localization. CJM tumors had …