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Factors Affecting Detection Of A Cryptic Ambush Predator Using Camera Traps, With Implications For Snake Monitoring, Sarah Elizabeth Ebert Jan 2026

Factors Affecting Detection Of A Cryptic Ambush Predator Using Camera Traps, With Implications For Snake Monitoring, Sarah Elizabeth Ebert

Theses, Dissertations and Capstones

Camera traps are becoming increasingly popular in wildlife research because they can be deployed for long time periods with little maintenance and are much less invasive than traditional trapping methods. However, they are primarily used to study large mammals and have not been extensively tested for snake species, many of which are cryptic and understudied. The Adapted-Hunt Drift Fence Technique (AHDriFT) arrays were designed to improve detection of herpetofauna by attaching camera traps to drift fences. In the summer of 2022, we installed 20 AHDriFT arrays at the Marine Corps Recruit Depot Parris Island in coastal South Carolina where we …


Umbralisib Antagonizes Multidrug Resistance In Abcb1- Overexpressing Cancer Cells, Letao Bo Jan 2026

Umbralisib Antagonizes Multidrug Resistance In Abcb1- Overexpressing Cancer Cells, Letao Bo

Theses and Dissertations

Overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, is a major mechanism of multidrug resistance (MDR) and contributes to chemotherapy failure by reducing intracellular drug accumulation. Umbralisib is a dual inhibitor of phosphoinositide 3-kinase delta (PI3Kδ) and casein kinase 1 epsilon (CK1ε) that was developed for the treatment of hematologic malignancies; however, it was later withdrawn due to safety concerns. In the present study, we found that umbralisib has the potential to reverse ABCB1-mediated MDR. The MTT assay demonstrated that umbralisib significantly sensitized ABCB1-overexpressing KB-C2 and SW620/Ad300 cells, as well as ABCB1-transfected HEK293 cells. Mechanistic assays revealed that umbralisib enhanced …


Prevention Of Inflammation-Associated Neurodegeneration: Assessing The Efficacy Of N,N-Dimethylacetamide (Dma) In Lipopolysaccharide (Lps)-Induced Neuroinflammation Using C57bl/6 Mice, Teeshavi Devi Acosta Jan 2026

Prevention Of Inflammation-Associated Neurodegeneration: Assessing The Efficacy Of N,N-Dimethylacetamide (Dma) In Lipopolysaccharide (Lps)-Induced Neuroinflammation Using C57bl/6 Mice, Teeshavi Devi Acosta

Theses and Dissertations

Neurological function is closely linked to both longevity and quality of life. While some degree of neurodegeneration occurs naturally with aging, pathological neurodegeneration leads to devastating functional decline. The mechanisms underlying these processes remain incompletely understood; however, neuroinflammation is recognized as a key driver of neuronal dysfunction and death. Emerging evidence indicates that neuroinflammatory cascades can precede and potentiate hallmark features of neurodegenerative diseases, including synaptic loss and cognitive decline observed in Alzheimer’s disease (AD). Activation of the NF-κB signaling pathway contributes to amyloid beta (Aβ) peptide production, further amplifying a cycle of inflammation and neuronal injury. Preclinical work from …


Effectiveness Of Walleye Stocking In Winter Kill Lakes, Tyler Haus Jan 2026

Effectiveness Of Walleye Stocking In Winter Kill Lakes, Tyler Haus

Journal of Earth and Life Science

Winter kill events, marked by extensive fish mortality due to hypoxic conditions under the ice, are a common phenomenon in shallow eutrophic lakes, especially in the northern lakes in the northern United States. These events can drastically alter fish communities and often result in the elimination of top predators. Though these lakes will typically slowly bounce back to what they were in a couple of years. This study evaluates the effectiveness of walleye, Sander vitreus, stocking in lakes after a winter kill. For this study, four known winter kill lakes that are consistently stocked with walleye were studied. Pre- …


Assessing Urban–Rural Differences In Largemouth Bass Abundance In Minnesota, Jonathan Gates Jan 2026

Assessing Urban–Rural Differences In Largemouth Bass Abundance In Minnesota, Jonathan Gates

Journal of Earth and Life Science

Urbanization can significantly alter freshwater ecosystems and influence sport fish populations. This study examined differences in largemouth bass Micropterus nigricans catch-per-unit-effort (CPUE) between urban and rural lakes in Minnesota and evaluated temporal changes between 2000–2010 and 2011–2021. Forty lakes (20 urban, 20 rural) were selected using Minnesota Department of Natural Resources fisheries survey data. Lakes were classified using NLCD 2019 land cover data, with ≥10% developed land designated as urban. Nonparametric analyses (Wilcoxon rank-sum and signed-rank tests) were used to assess spatial and temporal differences in CPUE. Results showed that rural lakes had consistently higher median CPUE than urban lakes …


Statewide Northern Pike Response To Minnesota’S 2018 Regulation Change, Elijah Wozniak Jan 2026

Statewide Northern Pike Response To Minnesota’S 2018 Regulation Change, Elijah Wozniak

Journal of Earth and Life Science

Management of northern pike (Esox lucius) is challenging because it attempts to balance ecological sustainability with angler interests. Northern pike often stunt their own growth by diminishing the size and abundance of prey fish, their food source. Anglers are often displeased when small pike occur in high population densities. In response to populations of small northern pike, the DNR implemented a new, statewide northern pike regulation in 2018. The objective of this study was to determine whether the regulation successfully changed the mean weight, length, and CPUE of northern pike in Minnesota. The secondary objective was to test …


Neonicotinoid Bioaccumulation In Bluegill And Bullhead Within Lake Julia And Lake Zumwalde, Jake Stuber Jan 2026

Neonicotinoid Bioaccumulation In Bluegill And Bullhead Within Lake Julia And Lake Zumwalde, Jake Stuber

Journal of Earth and Life Science

Brown Bullhead Ameiurus nebulosus, Yellow Bullhead Ameiurus natalis, and Bluegill Lepomis macrochirus are unique in their stark differences. Bullhead are scaleless bottom feeders that can tolerate high pollution and low O2 conditions. In contrast, Bluegill are scaled, aggressive nesters and are less tolerant of high pollutants or low-oxygen conditions. Among these pollutants include a class of chemicals called neonicotinoids (hereafter referred to as neonics). Neonics are a class of insecticides primarily used within agriculture and pest management. Due to the effectiveness, application has escalated on a global scale. They have been well documented by many toxicology assessments. …


Comparison Of Calcified Structures To Estimate Ages Of Northern Pike Esox Lucius In Various Lakes, Kaed Rauk Jan 2026

Comparison Of Calcified Structures To Estimate Ages Of Northern Pike Esox Lucius In Various Lakes, Kaed Rauk

Journal of Earth and Life Science

Northern pike Esox lucius are a dominant predatory fish in many aquatic systems. They can have significant impacts on the ecosystems they inhabit and are also a popular game fish among anglers. However, northern pike are a difficult species to age accurately. This study aimed to compare calcified aging structures to identify trends and determine which structure provides the most accurate age estimates. A total of 119 northern pike were sampled, and multiple structures from each fish were independently aged by two readers. The coefficient of variation (CV) was calculated for each structure to assess precision. Sectioned sagittal otoliths exhibited …


Indigenous Land Seizure & Environmental Injustice: Impacts Of Settler Colonialism, Lydia Moorman Jan 2026

Indigenous Land Seizure & Environmental Injustice: Impacts Of Settler Colonialism, Lydia Moorman

Journal of Earth and Life Science

The fields of conservation and environmentalism prioritize ecosystem health, yet both emerged from western frameworks that displaced and criminalized Indigenous land stewardship. The idealization of “pristine wilderness” narratives served to justify the removal of Indigenous peoples from their homelands and erased millennia of sustainable land stewardship that had maintained ecological balance long before western conservation existed. These narratives not only misrepresented Indigenous relationship with land but also constructed a false dichotomy between humans and nature that positioned Indigenous presence as a threat rather than a source of ecological knowledge. Simultaneously, anthropogenic expansion; such as pipelines, mining, railroads, and other extractive …


Size Structure Comparison Of Bluegill In Lakes With And Without Special Regulations, Jenna Lawin Jan 2026

Size Structure Comparison Of Bluegill In Lakes With And Without Special Regulations, Jenna Lawin

Journal of Earth and Life Science

Lots of individuals have mixed feelings about special regulations for all sorts of game fish species such as northern pike Esox lucius, crappie Pomoxis spp., sunfish Lepomis spp., and so on. One species commonly sought after by many is bluegill Lepomis macrochirus. Bluegill are often deemed easy to find, catch, and clean. This study looks at three different categories of lakes (all lakes contain bluegill populations). The three categories are lakes with a five sunfish limit, lakes with a ten sunfish limit, and lakes without any special regulations. This study provides valuable insight into the size …


Using L1-Magic For Feature Enhancement And Reduced Redundancy In Hyperspectral Data, Ashley Alfred Jan 2026

Using L1-Magic For Feature Enhancement And Reduced Redundancy In Hyperspectral Data, Ashley Alfred

Mathematics Dissertations

Hyperspectral imaging offers detailed spectral information, but achieving high spatial resolution typically requires large and expensive equipment. This study explores an alternative approach: enhancing low-quality hyperspectral bands using an L1-norm minimization technique known as L1-magic. The goal is to improve the utility of low-cost hardware by preserving discriminative features, promoting sparsity, and reducing spectral redundancy. We apply L1-magic to enhance low-quality bands and hypothesize that this method selectively amplifies key features while suppressing redundant information. Experimental results indicate that the enhanced bands approach the quality of high-resolution data, enabling robust feature extraction without reliance on high-end hyperspectral cameras.


Understanding Motor Competence In Autism And Developmental Coordination Disorder: From Everyday Performance To Underlying Postural Control Mechanisms, Crystal E. Alvarez Jan 2026

Understanding Motor Competence In Autism And Developmental Coordination Disorder: From Everyday Performance To Underlying Postural Control Mechanisms, Crystal E. Alvarez

Kinesiology Dissertations

Motor competence plays a foundational role in children’s participation, physical activity, adaptive behavior, and overall quality of life. Although motor difficulties are highly prevalent in autism spectrum disorder (autism) and developmental coordination disorder (DCD), these challenges are frequently under-identified and insufficiently characterized, particularly in autistic populations. Existing research demonstrates substantial overlap in motor challenges across autism and DCD; however, relatively little work has integrated caregiver perceptions, standardized motor assessment, and mechanistic postural control measures within the same investigation. Therefore, the purpose of this dissertation was to examine motor competence and postural control in autistic children, children with DCD, and neurotypical …


Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee Jan 2026

Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee

Graduate Theses/Dissertations

Land alterations can reduce the amount of suitable habitat necessary for persistence of an associated species. Within such constrained habitats, limited resources may elicit competition, which could cause shifts in abundance and occurrence of species. Missouri prairies have been declining in size, making it imperative to collect reference data on mammal populations within and land use types around remnants. For this study, I trapped small mammals in Southwestern Missouri prairies because they can be indicators of environmental health and can vary in abundance between prairies. I focus on the diet of two dominant small mammals, Peromyscus maniculatus and Microtus ochrogaster …


Extending The Fruiting Season With Container Grown Primocane-Fruiting Blackberries Grown In A High-Tunnel, Edwin James Tucker Iii Jan 2026

Extending The Fruiting Season With Container Grown Primocane-Fruiting Blackberries Grown In A High-Tunnel, Edwin James Tucker Iii

Graduate Theses/Dissertations

Blackberry production has become an important part of many small fruit orchard operations because they’re easy to grow, produce a large crop, and sell well at market. The current blackberry season in Missouri extends from mid-June to mid-August, depending on the cultivar chosen. This fruiting season is common for floricane-fruiting blackberry cultivars (cultivars that fruit on one-year old canes). Primocane-fruiting blackberry, or blackberries that fruit on current season growth, have the potential to further extend the harvest season of blackberry into September and October especially if grown in a high-tunnel. This study had two objectives. The first objective was to …


Perfluorooctane Sulfonate (Pfos)-Induced Disruption Of Mitochondrial Activity And Cell Adhesion In Liver Cells, Phuong Dam Nam Tran Jan 2026

Perfluorooctane Sulfonate (Pfos)-Induced Disruption Of Mitochondrial Activity And Cell Adhesion In Liver Cells, Phuong Dam Nam Tran

Graduate Theses/Dissertations

Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant associated with potential hepatoxic effects and other health risks. Despite its widespread distribution, the mechanisms underlying its toxicities remain to be fully understood. To investigate PFOS toxicology, my study utilized HepG2 and THLE-2 human hepatic cell models to replicate conditions reflecting PFOS accumulation in the liver. Cell viability, cell stress, and cell death assays were conducted to assess the toxicological influence of the chemical on both cell lines. Total RNA extraction was performed, followed by cDNA sequencing, and RT-qPCR. The XTT viability assay revealed a dose-dependent decrease in number of viable cells …


Eastern Fox Squirrel (Sciurus Niger) Occupancy In A Southern Missouri Woodland, Daniel Garten Jan 2026

Eastern Fox Squirrel (Sciurus Niger) Occupancy In A Southern Missouri Woodland, Daniel Garten

Graduate Theses/Dissertations

Species occupancy, which relates the probability of presence of a species at a specific place and time, is an important component of conservation and wildlife management. Principally it is used for estimation of a species’ distribution as well as understanding species interactions and quantifying environmental effects. The purpose of this study was to analyze occupancy of the Eastern Fox Squirrel (Sciurus niger) across multiple seasons (2019–2022) at Bull Shoals Field Station (BSFS), and to identify potential covariates associated with detection and colonization. Data were drawn from camera trap surveys from 26 sites during summer and fall seasons. Multi-season occupancy models …


N-Allylation Of Secondary Amides With Unsymmetrical Propionates, Remi Graff Jan 2026

N-Allylation Of Secondary Amides With Unsymmetrical Propionates, Remi Graff

Honors Theses

The combination of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and Et3N promotes the N-allylation of 4-methoxyacetanilide 2 with unsymmetrical propionates 1 (eq 1). The amide substrate is believed to undergo conversion to a nucleophilic silyl imidate in the presence of TMSOTf and the amine base, which concurrently promotes carbocation formation in the same flask through the loss of trimethylsilyl propionate, leading to N-allylation of the amide. A range of unsymmetrical propionates, accessed by varying the R and R’ substituents, react efficiently in this one-pot process with yields ranging from 44% to 99%, affording regioselective ratios of up to >20:1 through formation of regioisomers …


Development Of A Python Pipeline For The Inference Of Selection In Human Genomes And Applications To Adh1b*2, Aine Macdermott Jan 2026

Development Of A Python Pipeline For The Inference Of Selection In Human Genomes And Applications To Adh1b*2, Aine Macdermott

Honors Theses

Human evolutionary genomics provides an avenue to understand how genetic variation has been impacted by the environmental pressures of the past, revealing how selective pressures impacted past populations and contributed to present-day biological diversity. In this thesis, I describe the construction of a Python-based computational pipeline designed to automate and integrate multiple analyses of positive selection across worldwide population datasets, including derived allele frequency calculation, haplotype-based tests of selection, RELATE-based genealogical inference, and CLUES2-based temporal modeling. By automating file preparation, format conversion, job submission, result aggregation, model comparison, and visualization, this pipeline streamlines the data interpretation process, and shifts focus …


Exploring Phosphoregulation Of Myo3a Using Quantitative Fluorescence Image Analysis In Cos7 Cells, Vu Hao Minh Nguyen Phan Jan 2026

Exploring Phosphoregulation Of Myo3a Using Quantitative Fluorescence Image Analysis In Cos7 Cells, Vu Hao Minh Nguyen Phan

Honors Theses

Myosin 3A (MYO3A) is an unconventional myosin involved in the formation and maintenance of hair-cell stereocilia of the sensory epithelia in the inner ear. The kinase domain has been implicated in phosphoregulation of MYO3A activity through intermolecular autophosphorylation. Previous studies using mass spectrometry identified two potential phosphorylation sites in the motor domain. To investigate the regulatory roles of these sites, we generated glutamic acid point mutations in our mchr-MYO3AΔK construct to mimic phosphorylation and assayed the constructs for their ability to tip-localize and influence filopodial density via transfection into COS7 cells. The phosphomimic constructs were less able to generate filopodia …


Field-Scale Evaluation Of Satellite- Derived Vegetation Indices And Image Timing For In-Season Nitrogen Management In Corn, Ana Morales-Ona, Katsutoshi Mizuta, James J. Camberato, Robert Nielsen, Yuxin Miao, Davide Cammarano, German Mandrini, Daniel Quinn Jan 2026

Field-Scale Evaluation Of Satellite- Derived Vegetation Indices And Image Timing For In-Season Nitrogen Management In Corn, Ana Morales-Ona, Katsutoshi Mizuta, James J. Camberato, Robert Nielsen, Yuxin Miao, Davide Cammarano, German Mandrini, Daniel Quinn

Plant and Soil Sciences Faculty Publications

Introduction: Traditional methods to determine the agronomic optimum nitrogen rate (AONR) for corn (Zea mays L.) rely on grain yield data, limiting in-season decision-making for nitrogen (N) management. Vegetation indices (VIs) derived from satellite imagery can serve as proxies for grain yield and help estimate in-season AONR, enabling timely sidedress applications. This study aimed to (1) quantify how VI–yield relationships vary during the vegetative period across fields with different tillage systems and crop residue; (2) determine whether VI–N response curves can be used to estimate AONR (AONRvi); and (3) assess the accuracy of AONRvi relative to yield-based AONR (AONRy). …


Ovipositional Behavior Of The Twig Girdler (Cerambycidae: Oncideres Cingulata) On Stems Of Mockernut Hickory (Carya Tomentosa) In Arkansas, R. Tumlison, L. Serviss Jan 2026

Ovipositional Behavior Of The Twig Girdler (Cerambycidae: Oncideres Cingulata) On Stems Of Mockernut Hickory (Carya Tomentosa) In Arkansas, R. Tumlison, L. Serviss

Journal of the Arkansas Academy of Science

The Twig Girdler (Cerambycidae: Oncideres cingulata) is a long-horned beetle that girdles stems of certain species of trees to prepare a habitat for its offspring. The stems eventually die, break, and fall from the tree, but the beetle usually had already laid its eggs within the stems. Eggs are laid singly, almost always at growth rings or leaf bases. Because the space for the young to develop is finite, laying too many eggs could cause reproductive failure and too few eggs would be suboptimal. We hypothesized that the female laying eggs should be able to evaluate the stem and …


Biochemical Investigations Of F420-Dependent Glucose-6-Phosphate Dehydrogenase From Cryptosporangium Arvum, Sarah T. Al-Noubani Jan 2026

Biochemical Investigations Of F420-Dependent Glucose-6-Phosphate Dehydrogenase From Cryptosporangium Arvum, Sarah T. Al-Noubani

2026 Spring Honors Capstones Projects

F420-dependent glucose-6-phosphate dehydrogenase (FGD) catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconolactone using the deazaflavin, Cofactor F420. FGD from Mycobacterium tuberculosis has been investigated due to its health relevance to prodrug activation. More recently, FGD from Cryptosporangium arvum (Cryar- FGD) has been investigated due to its broader substrate specificity toward multiple sugar phosphates. Kinetic and NMR studies have shown that Cryar-FGD has dual catalytic activity as a dehydrogenase and isomerase. Further investigations are being conducted on Cryar-FGD to characterize key residues involved in catalysis.

To investigate the catalytically active residues of Cryar-FGD, …


Bulletin 4936: Guidelines To Importing And Keeping Regulated Animals In Western Australia, Win Kirkpatrick Jan 2026

Bulletin 4936: Guidelines To Importing And Keeping Regulated Animals In Western Australia, Win Kirkpatrick

Bulletins 4000 -

Updated:

  • January 2026 after a review of permit keeping conditions.
  • December 2025 for transfer of restricted keeping bird permit business to DPIRD.

Introduced, exotic or alien animals are species that have been brought to a country or location where they do not occur naturally. (Hereafter referred to as introduced species). Mammals, birds, reptiles, and amphibians that are introduced or relocated to new areas often cause problems to agriculture, the environment and the community. Problems occur when introduced species:

  • damage agricultural crops
  • displace and compete with native animals and plants
  • carry disease or parasites
  • damage property
  • cause land degradation
  • have a …


The Rna-Binding Protein Pumilio Limits Polymodal Noiception In Drosophila Larvae, Sara Palega, Hannah Davenport, Rebeccah K. Stewart, Jessica Horton, Andrew Bellemer Jan 2026

The Rna-Binding Protein Pumilio Limits Polymodal Noiception In Drosophila Larvae, Sara Palega, Hannah Davenport, Rebeccah K. Stewart, Jessica Horton, Andrew Bellemer

Microbiology & Molecular Cell Biology Faculty Publications

Nociception is the process by which the nervous system detects and processes information about potentially harmful environmental stimuli to generate behavioral and physiological responses. The process of nociception undergoes plasticity in response to injury, inflammation, and infection to shape the sensitivity of nociceptive circuits and the behavioral responses they control. We are increasingly aware that post-transcriptional regulation of gene expression shapes the sensitivity and plasticity of nociceptive sensory neurons and nociceptive behavior. In Drosophila, the Pumilio RNA-binding protein interacts with diverse target mRNAs to regulate their abundance and translation in a wide range of contexts including the establishment of …


Sae For All: Curriculum Guide, Emily Carpenter Jan 2026

Sae For All: Curriculum Guide, Emily Carpenter

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

Supervised Agricultural Experience (SAE) is a critical component of agricultural education, designed to provide students with hands-on learning opportunities that extend beyond the classroom. The SAE for All model ensures that every student participates in meaningful experiential learning tailored to their interests and career goals. By integrating SAE into the curriculum, students develop technical skills, career readiness competencies, and an understanding of real-world agricultural applications. This guide includes a teaching plan and a comprehensive set of assignments.


The Impact Of Regional Fishery Management Organization Structure On Collaborative Performance, Evelyn Roozee, Owen Temby, Gordon M. Hickey Jan 2026

The Impact Of Regional Fishery Management Organization Structure On Collaborative Performance, Evelyn Roozee, Owen Temby, Gordon M. Hickey

School of Earth, Environmental, & Marine Sciences Faculty Publications

Collaboration is integral to understand, plan, coordinate, and implement management measures for fisheries that cross international borders. Regional Fishery Management Organizations (RFMOs) are the main arenas for countries to collaborate and make decisions for transboundary fisheries, but these organizations have generally failed to prevent the depletion of some of the world's most valuable fish stocks. It is unclear how the structure and functioning of RFMOs can improve collaborative performance to better manage transboundary fish stocks. Using fuzzy-set qualitative comparative analysis, our study analyzes 10 RFMOs to identify the combination of six organizational conditions associated with high and low collaborative performance. …


Biomarkers Of Foraging And Reproduction In Captive Adult Female Hawksbill Sea Turtles (Eretmochelys Imbricata), Joslyn Blessing Kent, Kari Renee Dawson, Shingo Fukada, Masae Makabe, Isao Kawazu, Ken Maeda, Roldán A. Valverde Jan 2026

Biomarkers Of Foraging And Reproduction In Captive Adult Female Hawksbill Sea Turtles (Eretmochelys Imbricata), Joslyn Blessing Kent, Kari Renee Dawson, Shingo Fukada, Masae Makabe, Isao Kawazu, Ken Maeda, Roldán A. Valverde

School of Earth, Environmental, & Marine Sciences Faculty Publications

Hawksbill sea turtles (Eretmochelys imbricata) are listed as critically endangered by the International Union for the Conservation of Nature (IUCN). To implement best conservation practices for this species, its biology should be well understood. Attempting to characterize the foraging physiology of free-ranging hawksbill sea turtles is complicated by the fact that sampling is typically limited to nesting females during the reproductive season. Without data from non-reproductive periods, it is difficult to determine whether observed physiological values reflect baseline conditions or are specific to the energetically demanding nesting season. Accordingly, in this study, we described the physiology of foraging in …


Dielectrophoretic Biomarkers For Cancer Detection And Cell Analysis: Integrating Microfluidics And Ai, Raphael Olumide Oladokun Jan 2026

Dielectrophoretic Biomarkers For Cancer Detection And Cell Analysis: Integrating Microfluidics And Ai, Raphael Olumide Oladokun

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pancreatic ductal adenocarcinoma (PDAC) carries a five-year survival rate of 13%, driven largely by late-stage diagnosis and the absence of sensitive noninvasive screening tools. Current diagnostic methods lack the sensitivity to detect disease-associated systemic changes at early and precancerous stages, representing a critical clinical gap. This dissertation addresses the central hypothesis that PDAC and its pathological subtypes induce measurable, disease-associated electrophysiological changes in circulating PBMCs that can serve as correlative liquid-biopsy biomarkers. To test this hypothesis, this work asks: can dielectrophoresis (DEP), impedance and zeta potential analysis with AI-assisted classification distinguish benign pancreatic conditions (non-malignant control), precancerous lesions (primarily IPMNs), …


The Histamine-3 Receptor In Cardiac Fibrosis: A Novel Role In Fibroblast Function, Heather Linsky Jan 2026

The Histamine-3 Receptor In Cardiac Fibrosis: A Novel Role In Fibroblast Function, Heather Linsky

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the United States, heart failure affects approximately 6.7 million individuals. Despite a number of available therapies, heart failure prevalence continues to grow, suggesting the need for a broader range of effective therapies. More specifically, heart failure with preserved ejection fraction comprises approximately 50% of all heart failure cases and, as the name suggests, is a disease of diastolic dysfunction as opposed to systolic dysfunction. A hallmark of heart failure with preserved ejection fraction is myocardial fibrosis, which is a key contributor to diastolic dysfunction, and is the major focus of this dissertation work. In the heart, histamine-3 receptor activation …


Macroinvertebrate Response To Two Highway Construction Projects In West Virginia, Brenden Nauman Jan 2026

Macroinvertebrate Response To Two Highway Construction Projects In West Virginia, Brenden Nauman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Highway development and construction are frequently required to provide efficient transportation for an increasing human population. Specific to the Appalachian region, highway development has been a major goal since the mid 1900’s, with the aim of promoting economic growth and ease of travel. While highways provide necessary services to humans, their construction and presence often impact nearby waterways through multiple mechanisms including sedimentation and urbanization. To understand the degree of impact, streams are often monitored using biological data, which can be used to quantify effects. In this work I used freshwater macroinvertebrate communities to monitor changes in stream health surrounding …