Digital Commons Network^™

Survivin And C-Reactive Protein Serum Levels In Acne Vulgaris Patients In Relation To Its Severity, Asmaa Ayman Gouda, Sara Hamdy Fouad, Hyam Sameh Nada, Hanan Ahmed Salem

Mansoura Medical Journal

Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit with variable clinical severity. Increasing evidence suggests that acne may represent a localized inflammatory condition with potential systemic inflammatory involvement. Survivin, an inhibitor of apoptosis protein has been implicated in abnormal keratinocyte and sebocyte survival, while C-reactive protein (CRP) is a biomarker of systemic inflammation.

Aim of the study: To evaluate serum survivin and CRP levels in cases with AV compared to healthy controls and to assess their relationship with disease severity.

Subjects and methods: This case-control study included 45 patients with clinically diagnosed AV and 45 …

Clinico-Epidemiological Profile Of Iron Deficiency Anemia Among Egyptian Primary School Aged Children: A Hospital Based Study, Rabab Fathy Abdelhamid, Noha Essam, Mona Mohamed Taalab

Mansoura Medical Journal

Background: Iron deficiency anemia (IDA) is the most prevalent cause of anemia among Egyptian children and is associated with a range of hematologic and non-hematologic complications, some of which may be irreversible. This study aims to evaluate the clinical profile and identify factors associated with severe IDA in primary school–aged children.

Methods: This cross-sectional study included 420 primary school–aged children diagnosed with IDA who attended the outpatient clinic of Salamoun El-Qumash Family Medicine Centre. Data were collected through face-to-face interviews using a structured questionnaire. All participants underwent a thorough clinical examination and laboratory evaluation, including a complete blood count and …

Quality-Of-Life Outcomes Of Tympanoplasty/Mastoidectomy Operations, Peter Shokr Meglaa, Ahmed Hemdan Eldeeb, Hisham Atef Abada, Yousef Kamel Shabana

Mansoura Medical Journal

Background: Chronic suppurative otitis media (CSOM) impairs quality of life (QoL) via otorrhea, hearing loss, and psychosocial effects, with surgery (tympanoplasty/mastoidectomy) as mainstay treatment despite limited patient-centered outcome data. This study aimed to evaluate QoL changes post-tympanoplasty/mastoidectomy in CSOM using validated tools.

Methods: This prospective study included 50 adults with CSOM at Mansoura University Hospitals. Pre/postoperative assessments included Chronic Otitis Media Outcome Test-15 (COMOT-15), Short Form-36 Health Survey (SF-36), Hearing Handicap Inventory for the Elderly-Screening (HHIE-S), Tinnitus Evaluation Questionnaire (TEQ), Situational Vertigo Questionnaire (SVQ), pure tone audiometry (PTA), and air-bone gap (ABG).

Results: PTA improved from 48.5±10.2 to 28.3±8.4 dB …

Diffusion Weighted Magnetic Resonance Imaging In Rectal Cancer, Ebtehal A. Mohamed, Fatma Mohamed Sherif, Wael Abdulghaffar, Ahmed M Fareed, Gehad A. Saleh

Mansoura Medical Journal

Background: Rectal cancer (RC) is a major cancer burden globally as it is among the tumors that are most frequently diagnosed worldwide and a significant contributor to global cancer mortality yearly. Imaging with diffusion weighting (DWI) and Magnetic resonance imaging (MRI) is the best radiological modality for the local staging and restaging of RC due to its excellent soft-tissue contrast and high spatial resolution.

Aim of the work: This study aims to assess the value of DW-MRI in staging and assessing treatment response in patients with RC who received concurrent chemoradiotherapy.

Methods: Forty-two patients with RC diagnoses …

The Potential Role Of Naftidrofuryl Oxalate In Rat Model Of Ulcerative Colitis, Omar Mohsen Elmazny, Ahmed Abdel-Monem Elmetwally, Vivian Boshra, H.M. El-Beltagi, Basma Hamed Othman, Heba Sheta

Mansoura Medical Journal

Background: Ulcerative colitis (UC) is a chronic, recurrent bowel disease characterized by inflammation that leads to superficial damage to the colon wall. The rate of incidence of UC differs from 0.5 to 31.5 per 100,000 subjects annually. The exact cause is still not well-identified. Studies suggest genetic factors, altered immune response, and environmental factors may play a role in the initiation and progression of the disease. Its pharmacological treatment remains unsatisfactory. Aim: To assess the possible protective effect of Naftidrofuryl oxalate (NFT) (praxilene) on intestinal epithelial cells in acetic acid (AA)-induced UC model in rats.  Materials and Methods: sixty female …

Added Value Of T2 Space Stir In Magnetic Resonance Imaging Evaluation Of Post-Traumatic Brachial Plexus Injury, Nehal Tharwat, Ahmed Mohamed Abdelkhalek, Mohamed Ashraf Abd El-Moniem, Hesham Abdel Fattah Elsobky, Ahmed Alaa El-Din Elagamy

Mansoura Medical Journal

Background: Traumatic brachial plexus injuries (TBPIs) cause severe upper limb disability. Owing to the complex anatomic architecture of the brachial plexus (BP), TBPIs are difficult to diagnose. Magnetic resonance neurography of the BP using three-dimensional isotropic imaging provides excellent background fat suppression and adequate soft-tissue contrast, thereby allowing better delineation of the BP along its pathway. This study aimed to compare image quality between T2-Short tau inversion recovery (T2-STIR) and 3D-transverse relaxation time-sampling perfection with application of optimized contrasts using different flip-angle evolution short tau inversion recovery (3D-T2 SPACE STIR) sequences in cases of TBPIs.

Methods: This study included 44 …

Hypoalbuminemia As A Predictive Factor For Acute Kidney Injury In Pediatric Patients Running Title: Hypoalbuminemia In Aki Pediatrics, Kareem El-Saeed El-Maasrany, Ayman Hammad, Hosam Zaghloul, Ahmed Elhusseiny

Mansoura Medical Journal

Aim: Hypoalbuminemia is a well-known risk factor for illness and death, but its role as a particular predictor of acute kidney injury (AKI) is still not fully understood. This study intended to evaluate the role of hypoalbuminemia as a predictive factor for AKI outcome among pediatric patients, regarding hospital stay, kidney replacement therapy and mortality rate.

Subjects and Methods: This prospective observational cohort was conducted on 70 children with AKI divided into two groups: group I (35 AKI children combined with hypoalbuminemia) and group II (35 AKI children without hypoalbuminemia). All participants were subjected to full history taking, clinical examination …

Evaluation Of Β2-Microglobulin In Patients With Psoriasis Vulgaris Case Controlled Study, Ishraq Mazhar Shaaban, Fatma Faisal El Dakrory, Alshaimaa Hamdi Abd Elmaksoud, Youssef El-Bayoumi Youssef Soliman

Mansoura Medical Journal

Background: Psoriasis is a persistent, immune-mediated dermatological condition influenced by complex genetic architectures and systemic inflammation. This investigation evaluated the diagnostic utility of serum β2-microglobulin β2 as a quantitative indicator for gauging clinical severity in psoriatic patients.

Aim of the work: The primary objective of this investigation was to evaluate the diagnostic utility of serum β2-microglobulin (β2M) as a quantitative biomarker for assessing disease severity in patients with psoriasis vulgaris. Specifically, the study sought to determine the correlation between circulating β2M levels and established clinical parameters, including the Psoriasis Area and Severity Index (PASI), body mass index (BMI), and …

Assessment Of Health-Related Quality Of Life In Pediatric Patients With End Stage Renal Diseases, Nasteho Adan Awil, Ahmed Mahmoud Elrefaey, Abdel-Hady El-Gilany Abdel-Elfattah, Heba Mohamed El-Taher

Mansoura Medical Journal

Background: End-stage renal disease (ESRD) occurs when the glomerular filtration rate falls below 15 mL/min, requiring renal replacement therapy. Despite improved survival, affected children experience significant physical, emotional, and social challenges. Consequently, health-related quality of life (HRQoL) is markedly reduced compared with healthy peers.

Aim: This study aimed to assess health-related quality of life (HRQOL) in pediatric patients with end-stage renal disease (ESRD) and to identify factors associate with the quality of life in pediatric patients with   end stage renal disease (ESRD).

Methods:  All 60 eligible children who were enrolled in the Nephrology Unit at Mansoura University Children's Hospital …

Evaluation Of Cardiac Troponin T And Ischemia-Modified Albumin Changes With Hemodialysis Session In Pediatric Patients With End-Stage Renal Disease, Zeinab Ezz Elden Abass Abd Eldayem, Ashraf Mohammed Abdel Basset, Gehan Attia Abdehakem, Shiama Abdelmgiad, Nermin Yossef Abo Elkheir

Mansoura Medical Journal

Background : Cardiovascular status in dialysis patients is complicated by a wide range of factors that can affect long-term prognosis. Cardiac biomarkers changes with hemodialysis session could affect the cardiac integrity of those patients. Aim of the work: Assess the changes of cardiac ischemic biomarkers (Troponin T and ischemia modified albumin) before and after hemodialysis session in patients with ESRD in pediatric age group and study of correlations of changes with the hemodialysis parameters. Patients and methods: The study included 40 pediatric ESRD patients who were admitted to Pediatric Cardiology Unit, Pediatric Nephrology and Dialysis Unit of Mansoura University Children’s …

Diagnostic Accuracy Of Combined B-Mode Ultrasound, Color Doppler And Strain Elastography In Assessment Of Cervical And Axillary Lymph Nodes, Marwa Mostafa, Nihal M. Batouty, Amani Ezzat Mousa

Mansoura Medical Journal

Background: Lymphadenopathy is a common condition caused by many benign and malignant disorders; therefore, determining their nature is important in clinical setting. The objective of research is to assess diagnostic accuracy of B-mode ultrasound, color Doppler, and strain elastography in lymph nodes evaluation with pathological correlation and to determine cut-off value of strain ratio that differentiates benign from malignant nodes.

Methods: All patients underwent ultrasound examination, Doppler study and strain elastography in supine position using a high-frequency probe (6.2-12 MHz). Out of 80 enrolled patients, only 53 were subjected to biopsy from the lymph nodes, then their pathological results …

Fascia Transversalis Block With Different Volumes Of Local Anesthetic And Its Impact On Postoperative Pain In Major Abdominal Surgery: Prospective Randomized Study, Eman Eltabey Lotfi Taman, Mostafa Mohamed Ali Saied, Khaled Mohy Eldeen El Bahrawy, Abdelrahman Mamdouh El Naggar

Mansoura Medical Journal

Background Effective postoperative analgesia remains crucial in abdominal surgery to reduce physiological stress, improve respiratory function, and enhance recovery. The transversalis fascia plane block (TFPB) has recently emerged as an advantageous technique targeting the T12–L1 nerves responsible for somatic and visceral abdominal innervation. Objective To investigate the analgesic efficacy of different volumes of local anesthetic administered in TFPB and compare their effect on postoperative pain, visceral discomfort, and opioid requirements. Methods Eighty-one adult patients undergoing major abdominal surgery under general anesthesia were randomized into 3 groups: control (systemic analgesia only), lowvolume TFPB (20 mL total), and high-volume TFPB (25 mL …

Diagnostic Performance Of Digital Breast Tomosynthesis In The Characterisation Of Breast Lesions: Correlation With Sono-Mammography And Histopathology., Amira Hamed Megahed, Mona Mahmoud Zaky, Maha Mohamed Bilal

Mansoura Medical Journal

Background: Breast lesions range from benign to malignant, with early detection critical for management. Digital mammography is the standard screening tool but may be limited in dense breasts. Ultrasound (US) aids lesion characterisation, while digital breast tomosynthesis (DBT) reduces tissue overlap, enhancing lesion detection.

Objective: To evaluate the diagnostic performance of digital breast tomosynthesis in the characterisation of breast lesions compared with sono-mammography, using histopathology as the reference standard.

Methods: This prospective study included 33 symptomatic female patients with a mean age (45.4 ± 8.2 years) who presented with symptoms such as palpable breast lumps, Mastalgia and nipple discharge between …

Assessment Of Serum Level Of Lipocalin-2 In Patients With Alopecia Areata, Mohammed S. Sultan, N. M. Darwish, Hosam Abdel Tawab, Asmaa M. Shalaby

Mansoura Medical Journal

Background: Alopecia areata (AA) is a chronic autoimmune disease (AID)-causing non-scarring hair loss (NSHL), mainly on the scalp. It affects about 2% of people worldwide, usually starting in the third or fourth decade. This study aimed to evaluate serum lipocalin-2 levels in AA patients compared to healthy controls (HC), and to examine their correlation with disease severity Methods: This one-year prospective case-control study included 40 AA patients from Mansoura University Hospitals and 40 age- and sex-matched healthy control. Diagnosis was based on typical, well-defined non-inflammatory scalp hair loss (HL) confirmed by dermoscopy. Controls were healthy, with no autoimmune history or …

Comparative Study Between Serum Levels Of Interleukin-19 And Interleukin-38 In The Egyptian Patients With Non-Segmental Vitiligo, Reem Ahmed Al Maaddawy, Mohamed Kh. Selim, Ahmed Fawzi Ismail, Ahmad S. Hasan, Manar Ali Hassan

Mansoura Medical Journal

Background: The precise etiology of vitiligo remains unclear; nonetheless, it is predominantly regarded as an autoimmune disorder. This work aimed to compare serum levels of IL-19 and IL-38 between patients with non-segmental vitiligo (NSV) and healthy controls (HC). Patients and Methods: This study included 88 participants, evenly split into two groups: 44 individuals with non-segmental vitiligo and 44 healthy controls. Both groups underwent full history taking. The Vitiligo Area Severity Index (VASI) score and Vitiligo Disease Activity (VIDA) score were used to assess disease severity and activity. The levels of human IL-19 and IL-38 were also measured.

Results:Serum IL-38 …

A Comparative Study Of Topical 5% 5-Fluorouracil With Needling Versus 100% Trichloroacetic Acid With Needling Versus Needling Alone In Treatment Of Multiple Warts, Nesma Abd-Elmonem Saad, Hassan A. Fayed, Manar Ali

Mansoura Medical Journal

Aim: This study aimed to compare the efficacy and safety of topical 5% 5-Fluorouracil (5-FU) with Needling versus 100% Trichloroacetic acid (TCA) with Needling versus Needling Alone in treatment of multiple warts.

Methods: This study included a total of 60 patients clinically diagnosed with multiple warts, who were randomly allocated (computer-generated simple randomisation, 1:1:1, concealed in sequentially numbered opaque sealed envelopes) into three equal groups (n=20 per group). The first group received 100% TCA with Needling; the second group received topical 5% 5-FU combined with Needling; the third group underwent Needling alone. The study was single-blinded at the level …

Active Deresuscitation Strategies After Septic Shock: A Scoping Review, Alrefaey K. Alrefaey, Rania E Elbadrawy, Mohamed Aboelela, Mohammed Mamoun

Mansoura Medical Journal

Background: Fluid overload in septic shock patients is linked to higher morbidity and mortality. After the stabilization phase, fluid restriction may not result in the resolution of tissue edema. Active deresuscitation refers to the use of diuretics or ultrafiltration for the removal of excess fluids. Objectives: This review explores the current practices applied for the active deresuscitation strategies after stabilization of septic shock patients.  Search strategy: A literature search was performed through the following databases: Medline, PubMed, Google Scholar, Web of Science, and Scopus for relevant studies from 2015 to January 2026. Selection criteria:  The selected articles included …

Evaluation Of Clinical Efficacy And Safety Of Topical Trifarotene Versus Topical Dapsone In Inflammatory Acne Valgaris: Split Face Interventional Study., Shaymaa E. Elmongy, Aya Mohammed Elsebaie, Azza Osama Alqurei, Noura A. Elseessy

Mansoura Medical Journal

Background: Topical Trifarotene and Dapsone both treat inflammatory acne, but they work differently and have distinct side effects.

Objective: to compare efficacy and safety between topical trifarotine 0.005% versus dapsone 5% gel for treatment of mild to moderate inflammatory facial acne vulgaris.

Methods: This split face interventional study included twenty (20) patients with mild to moderate facial acne vulgaris. All the patients were treated with topical trifarotine cream 0.005 once daily at night thin layer on RT side of the face and treated with topical dapsone gel 5% once daily at any time of the day thin …

Diffusion Mri Characterization Of Paranasal Sinus Masses, Fatma Elsayed Ali, Doaa Khedr Mohamed, Mohamed Magdy El-Rakhawy

Mansoura Medical Journal

Background: In ordinary clinical practice, a number of nasal cavity lesions, both neoplastic and non-neoplastic, are often seen. Because diffusion-weighted MRI imaging (DWI) captures the random migration of water protons, it provides superior characterization of tissues and their physiological processes. Therefore, the current study's goal was to use echoplanar DWI to classify malignant and non-malignant sinonasal lesions.

Methods: Fifty patients with paranasal sinus masses who were sent to Mansoura University Hospitals' Diagnostic Radiology Department for radiological examination, including a traditional MRI procedure, were included in this prospective research, Diffusion Weighted Images (DWI) and apparent diffusion coefficient (ADC). The final diagnosis …

Clinical Outcomes Of Anticoagulant Therapy In Cirrhotic Patients With Benign Portal Vein Thrombosis, Dalia Elsayed Tawfik, Muhammad Abdulaty Diasty, Aya Ahmed Elboghdady, Hatem Abdel Wahab Elalfy

Mansoura Medical Journal

Background

Portal vein thrombosis (PVT) is among the recognized vascular complications encountered in cirrhotic patients and may significantly influence disease progression and survival. The clinical course of PVT differs according to its etiology, particularly when hepatocellular carcinoma (HCC) is absent. This study was designed to assess the outcomes of benign portal vein thrombosis in cirrhotic patients.

Methods

This prospective observational study enrolled 18 cirrhotic patients diagnosed with non-malignant portal vein thrombosis. All participants underwent comprehensive clinical evaluation, laboratory investigations, and radiological assessment. Severity of liver disease was determined using the Child–Pugh classification and MELD score. Radiological imaging was utilized to …

Serum Magnesium Level And Carotid Artery Calcification And Stiffness In Dialysis Patients: Single Center Cross-Sectional Study, Kareem Ahmed Elbosaty, Alaa Abd Elaziz Sabry, Gehad Ahmad Saleh, Nehal Atef Elshabrawy

Mansoura Medical Journal

Introduction Vascular calcification is common among end-stage renal disease (ESRD) patients on regular dialysis, either hemodialysis or peritoneal dialysis. Magnesium is suggested to play a role in inhibiting that process. Recently, Mg started to be considered one of the factors that protect against vascular calcification and consequently decrease CVD mortality rate in CKD patients. Many recent studies support that role although the mechanism of that protective effect is not clear. But it is supposed to be a combination of both passive and active mechanisms. The passive one occurs through interference with calcium phosphate deposition and hydroxyapatite inhibition by phosphate binding. …

Explainable Multi-Horizon Wind Power Forecasting Via Aquila-Optimized Machine Learning Models, Mostafa A. Abdelnaby, Nahla B. Abdel-Hamid, Eman M. El-Gendy, Mahmoud M. Saafan

Mansoura Engineering Journal

The inherently unpredictable nature of wind energy necessitates the development of sophisticated forecasting models to ensure grid stability and optimal distribution. In this research, we propose a novel and systematic approach to wind power forecasting (WPF) across diverse timescales. This approach leverages the power of various machine learning (ML) models, metaheuristic hyperparameter optimization, and utilizes explainable artificial intelligence (XAI). The developed methodology is based on the Aquila optimizer (AO), capable of automatically adjusting different ML models for four different time periods (30 minutes, 6 hours, 24 hours, and 36 hours) on the data collected from the Gabal El-Zayt wind power …

Effect Of Two Cut Off Rows On Seepage Underneath Hy-Draulic Structures Using Weak Form Differential Quadra-Ture Element Method: A Theoretical Approach, Esraa Ahmed, El-Masry A. A, Hossam A.A. Abdel Gawad, Ahmed Elhamrawy

Mansoura Engineering Journal

Investigating confined seepage underneath hydraulic structures is crucial to ensure the safety of these structures. The Weak Form Quadrature Element Method (WFQEM) is the basis of this paper, which explores the behavior of confined flow. The seepage flow governing equation is solved numerically to estimate the uplift pressure underneath the hydraulic structures and the exit gradient.The Gauss–Lobatto–Legendre (GLL) type is used as nodal and integration points. Several models were solved to validate the applied numerical method. The obtained results are compared with theoretical and preceding numerical solutions mentioned in the literature. The system of equations generated from applying the WFQEM …

A Hybrid Geospatial And Remote Sensing Methodology For Drought Vulnerability Assessment In Semi-Arid Ecosystems, Kaifi Fakhir Chomani

Mansoura Engineering Journal

The Kurdistan Region of Iraq (KRI) faced significant drought challenges due to global and environmental changes, necessitating drought assessments. Advanced techniques of remote sensing, Geographic Information Systems (GIS), and Analytic Hierarchy Process (AHP) were combined in this research to perform drought vulnerability zonation for KRI. Average annual rainfall, Average number of rainy days, Average annual temperature, slope, elevation, normalised difference water index (NDWI), normalised difference vegetation index (NDVI), land surface temperature (LST), and temperature condition index (TCI) were selected as contributing parameters for drought vulnerability assessments. The considered parameters were weighted using pairwise comparison, and thematic maps were created to …

Reduced Threat-Related Neural Efficiency: A Possible Biomarker For Pediatric Anxiety Disorders, Julia O. Linke, Reut Naim, Simona P. Haller, Parmis Khosravi, Beck Scheinberg, Meghan E. Byrne, Anita Harrewijn, Ellen Leibenluft, Melissa A. Brotman, Anderson M. Winkler, Daniel Samuel Pine

School of Medicine Publications

Objective: Pediatric anxiety disorders are common and predict adult psychopathology, yet current treatments, such as cognitive-behavioral therapy (CBT), produce lasting remission in less than 50% of affected youths. To support the search for improved, mechanistically grounded interventions, this study evaluated neural efficiency, defined as similarity in functional connectivity between a threat task and rest, as a potential biomarker. The study evaluated neural efficiency in relation to anxiety diagnosis and treatment response.

Methods: The authors compared 103 youths with an anxiety disorder diagnosis (mean age, 12.5 years [SD=2.91], 62% female) to 103 youths with no psychiatric diagnosis (mean age, 13.4 years …

Tree Composition And Carbon Turnover Dynamics Across 22 Years In A Costa Rican Premontane Moist Forest Fragment, Milena Cambronero, Fabián Araya-Yannarella, Lauren Holmes, Jill Cass

Student Publications [Scholarly]

Aim of study: Tropical forests are increasingly threatened by deforestation and fragmentation. In Costa Rica, extensive land-use change has left forest fragments whose long-term ecological dynamics remain poorly understood. This study assessed changes in tree diversity, composition, structure, and aboveground carbon stocks during a 22-year period (2000-2022) in a premontane moist forest fragment in Costa Rica. Area of study: Municipal Forest of Atenas (26.4-ha), Alajuela, Costa Rica. Material and methods: Tree inventories were conducted in 32 plots (10 m radius) in 2000 and 33 plots in 2022. We analysed diversity and composition using Bray-Curtis dissimilarity, Hill numbers, and Importance Value …

Preserved Artificial Grammar Learning In Individuals With Parkinson’S Disease: A Systematic Review, Sarah I. Cranna

Honors Theses and Capstones

Abstract

            Implicit statistical learning is a crucial cognitive function that is highly involved in the learning and processing of language. Since both language and implicit statistical learning are supported by the basal ganglia through cortico-striatal networks, disruptions to this network could result in their impairment. Parkinson’s Disease (PD) can therefore be used to model disruptions to this system as it is primarily characterized by dysfunction in the basal ganglia. Thus, this review aims to examine the current literature studying the performance of individuals with PD on artificial grammar tasks in order to investigate the impact of impaired basal ganglia function …

Fgf Signaling Is Necessary For Newt Lens Regeneration, Leo Alexander Napoleon

Honors Theses and Capstones

The Iberian ribbed newt Pleurodeles waltl can regenerate the lens by transdifferentiating iris pigmented epithelial (IPE) cells into lens epithelial cells (LECs), but the mechanism by which this occurs remains largely uncharacterized. We aim to mechanistically show an early and critical role for FGF signaling by using small molecules to inhibit FGF receptors and observe the histological and intracellular effects. Two inhibitors were found to completely stall lens regeneration. Cell cycle analysis revealed decreased DNA synthesis and uniformly low but unchanged entry to mitosis under signaling inhibition by staining for EdU incorporation and phospho-histone H3 (pH3), respectively. Western blot revealed …

Current And Historical Occurrences Of Rare Coastal Plants In The Hampton Falls Salt Marshes, Liliana T. Chirichella

Honors Theses and Capstones

A botanical survey of two sites in the Hampton Falls saltmarshes was conducted to document the occurrences of a list of eleven endangered and threatened coastal plants listed in the Natural Heritage Bureau’s NH Rare Plant List. This survey was conducted in fulfillment of the NH Native Plant Protection Act to highlight and identify target species in an area where restorative runneling is to be implemented in order to restore proper hydrology and prevent further expansion of mega-pools in the Little River and Depot Road salt marsh sites, which have been subject to historical ditching and are a part of …

Comparing The Differences Of Hsp90Α And Hsp90Β In Native Protein Complex Incorporation, Daryna Serediuk

Honors Theses and Capstones

Epichaperomes are long-lasting, stable assemblies of chaperones, co-chaperones, and associated factors that facilitate cell survival in maladaptive cellular states. Their inhibition has emerged as an attractive therapeutic strategy for the treatment of cancer and neurodegenerative diseases (Rodina et al., 2016). Epichaperomes are hallmarks of robust proliferation in cancer cell populations across many cancer types and are abundantly present in several stem cell varieties, including induced pluripotent stem cells, human embryonic kidney cells, and cancer stem cells (Kishinevsky et al., 2018).

The core protein of the eukaryotic heat shock protein machinery, Heat Shock Protein 90 (Hsp90), is a central chaperone that …