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Articles 4261 - 4290 of 256548
Full-Text Articles in Entire DC Network
The Promise Of Mindfulness-Based Interventions: A Stress-Reduction Strategy For Testicular Cancer Survivors' Health-Related Quality Of Life, Michael J. Rovito, Colin F. Mahony, Kamalie Thomas, Keith Brazendale, Ciaran Fairman Ph.D., Cscs, Cet
The Promise Of Mindfulness-Based Interventions: A Stress-Reduction Strategy For Testicular Cancer Survivors' Health-Related Quality Of Life, Michael J. Rovito, Colin F. Mahony, Kamalie Thomas, Keith Brazendale, Ciaran Fairman Ph.D., Cscs, Cet
Faculty Publications
Background: Testicular cancer (TC) disproportionately affects younger men and carries unique psychosocial and physiological consequences that extend well beyond treatment. Despite favorable survival rates, TC survivors frequently report diminished health-related quality of life (HRQoL). These burdens are often compounded by masculinity-related identity disruptions, fear of recurrence, sexual dysfunction, and a lack of tailored psychosocial support. Existing interventions remain limited, with most programs focused on physical rehabilitation or early detection. Few address the multidimensional stressors that shape the TC survivorship experience.
Aims: This narrative review examines the literature on HRQoL among TC survivors and evaluates the potential of mindfulness-based interventions (MBIs) …
Association Of Body Fatness With Hypertension, Dyslipidemia, And Myocardial Infarction In A Multinational Pooled Cohort, Vivek Kumar Prasad, Chibueze Ogbonnaya, Hannah Oh, Andrew Atkin, Madison Kindred, Min-Jeong Shin, Dahyun Park, Jin Eui Kim, Mike Loosemore, Vartika Saxena, Ryan Porter, Courtney Kipps, Jason Jaggers, Xuemei Sui M.D., M.P.H., Ph.D., Carl J. Lavie, Mark Hamer
Association Of Body Fatness With Hypertension, Dyslipidemia, And Myocardial Infarction In A Multinational Pooled Cohort, Vivek Kumar Prasad, Chibueze Ogbonnaya, Hannah Oh, Andrew Atkin, Madison Kindred, Min-Jeong Shin, Dahyun Park, Jin Eui Kim, Mike Loosemore, Vartika Saxena, Ryan Porter, Courtney Kipps, Jason Jaggers, Xuemei Sui M.D., M.P.H., Ph.D., Carl J. Lavie, Mark Hamer
Faculty Publications
Objective
To investigate the association of dual-energy X-ray absorptiometry–measured body fat percentage (BF%) and trunk fat mass index (TFMI) with hypertension (HTN), dyslipidemia, and myocardial infarction (MI).Methods
The relationship between body fat parameters and cardiovascular disease (CVD) was studied across individuals in the same body mass index (BMI) group. Data from the UK Biobank, a multicountry large population-based study, and the US and Korean National Health and Nutrition Examination Surveys, generating nationally representative samples, were pooled and harmonized. This cross-sectional analysis included 30,520 women and 27,244 men aged 40 years or older.Results
A significant increase in relative risks …How To Measure, Analyze, And Interpret Age-Related Changes In Caenorhabditis Elegans: Lessons For Mechanistic And Evolutionary Theories Of Aging, Zuzana Kocsisova, Brian M. Egan, Andrea Scharf, Xavier Anderson, Franziska Pohl, Aaron Anderson, Kerry Kornfeld
How To Measure, Analyze, And Interpret Age-Related Changes In Caenorhabditis Elegans: Lessons For Mechanistic And Evolutionary Theories Of Aging, Zuzana Kocsisova, Brian M. Egan, Andrea Scharf, Xavier Anderson, Franziska Pohl, Aaron Anderson, Kerry Kornfeld
Biological Sciences Faculty Research & Creative Works
Aging is characterized by progressive degenerative changes in tissue organization and function, some of which increase the probability of mortality. Major goals of aging research are to elucidate the series of events that cause degenerative changes, and to identify environmental, pharmacological, and genetic factors that influence these changes; this information might lead to new strategies to extend health span and lifespan. Mechanistic studies of aging depend on accurate and precise descriptions of age-related changes, since these descriptions define the aging phenotype. Here, we review studies that describe age-related changes in C. elegans, including measurements of integrated functions such as behavior …
To Hold Or Sell Breeding Cattle In The Rangelands, Department Of Primary Industries And Regional Development, Western Australia
To Hold Or Sell Breeding Cattle In The Rangelands, Department Of Primary Industries And Regional Development, Western Australia
Animal production and livestock factsheets
In a dry season where feed, water and finances are limited, removing less productive animals as soon as possible is a good option. This will free up feed for more productive animals and help preserve ground cover.
This page provides some of the information and a process for making decisions about holding or selling breeding cattle.
Fisheries Management Paper No. 311: West Coast Deep Sea Crustacean Resource Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia
Fisheries Management Paper No. 311: West Coast Deep Sea Crustacean Resource Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia
Fisheries Management Papers
Harvest strategies for Western Australia’s (WA) aquatic resources are formal documents developed by the Department of Primary Industries and Regional Development (DPIRD, the Department) to support decision-making processes that ensure the outcomes are consistent with the principles of Ecologically Sustainable Development (ESD; Fletcher 2002a) and Ecosystem Based Fisheries Management (EBFM; Fletcher et al. 2012). Harvest strategies are a key component of all contemporary fishery management systems and a requirement for certification under the Marine Stewardship Council (MSC). The objectives of ESD are reflected in the objectives of the Fish Resources Management Act 1994 (FRMA).
This West Coast Deep Sea Crustacean …
Effects Of A Carbohydrate + Caffeine Beverage On Game Performance, Blood Glucose And Perceived Effort In Collegiate Women Soccer Players, Andrew Jagim, Abby Ambrosius, Makenna Carpenter, Joesi Krieger, Lochlan Charley, Jennifer Fields, Margaret T. Jones, Chad Kerksick
Effects Of A Carbohydrate + Caffeine Beverage On Game Performance, Blood Glucose And Perceived Effort In Collegiate Women Soccer Players, Andrew Jagim, Abby Ambrosius, Makenna Carpenter, Joesi Krieger, Lochlan Charley, Jennifer Fields, Margaret T. Jones, Chad Kerksick
Faculty Scholarship
Carbohydrate availability and caffeine ingestion have been shown to elicit improvements in performance independently of one another. The purpose of the study was to examine the effect of a carbohydrate + caffeine beverage on performance and perceived effort in soccer players. Forty-three collegiate women’s soccer athletes were recruited to participate during a single day of simulated match play, in which each team played once. Athletes consumed either a carbohydrate + caffeine (Experimental) beverage or a control (Control) beverage (flavored water) during half-time in a double-blind, placebo-controlled, randomized control trial design. Prior to and after each game, Ratings of Perceived Exertion …
International Society Of Sports Nutrition Position Stand: Effects Of Dietary Antioxidants On Exercise And Sports Performance, Drew E. Gonzalez, Broderick L. Dickerson, Brandon M. Roberts, Jennifer A. Kurtz, Hunter S. Waldman, Adam M. Gonzalez, Matthew J. Mcallister, Jeffery L. Heileson, Richard J. Bloomer, Shawn M. Arent, Darren G. Candow, Jeffrey R. Stout, Karen A. Hecht, Bill Campbell, Chad Kerksick, Douglas Kalman, Jose Antonio, Richard B. Kreider
International Society Of Sports Nutrition Position Stand: Effects Of Dietary Antioxidants On Exercise And Sports Performance, Drew E. Gonzalez, Broderick L. Dickerson, Brandon M. Roberts, Jennifer A. Kurtz, Hunter S. Waldman, Adam M. Gonzalez, Matthew J. Mcallister, Jeffery L. Heileson, Richard J. Bloomer, Shawn M. Arent, Darren G. Candow, Jeffrey R. Stout, Karen A. Hecht, Bill Campbell, Chad Kerksick, Douglas Kalman, Jose Antonio, Richard B. Kreider
Faculty Scholarship
Following a comprehensive review, the International Society of Sports Nutrition (ISSN) has developed an official position on the role of dietary antioxidants in exercise and sport. Antioxidants play a complex, context-dependent role in vivo; they can facilitate recovery from exercise but may also hinder training adaptations when consumed at supraphysiological doses. While endogenous antioxidant systems can effectively maintain redox balance, dietary sources, particularly whole foods, can help mitigate excessive oxidative stress following intense/heavy training or inadequate recovery. The influence of dietary antioxidants depend on timing, dosage, type, and individual factors. The ISSN’s official position encompasses the following: (1) Redox balance …
Deep Amelioration Of Compaction And Acidity Doubled The Water Use Efficiency Of Cereal Crops On A Sandy Soil In A Long-Term Experiment In A Water-Limited Environment, Gaus Azam, Md. Shahinur Rahman, Craig Scanlan, Md. Hasinur Rahman, Ross Gazey, E G. Barrett-Lennard, Kanch Wickramarachchi, Bob Nixon, Chris Gazey
Deep Amelioration Of Compaction And Acidity Doubled The Water Use Efficiency Of Cereal Crops On A Sandy Soil In A Long-Term Experiment In A Water-Limited Environment, Gaus Azam, Md. Shahinur Rahman, Craig Scanlan, Md. Hasinur Rahman, Ross Gazey, E G. Barrett-Lennard, Kanch Wickramarachchi, Bob Nixon, Chris Gazey
Natural Resources Research Articles
The co-occurrence of subsoil compaction and acidity commonly decreases the yield and water use efficiency (WUE) of agricultural crops around the world, yet the benefits of the complete amelioration of these constraints on yield and WUE remain unclear. We conducted a long-term field experiment in Western Australia (WA) to evaluate the effects of the complete removal of subsoil compaction and acidity through soil profile re-engineering — involving soil removal, replacement, and lime incorporation — on root architecture, yield, and WUE in wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.). Treatments included an untreated control, and soil loosening to 0.45 …
American Kestrel Population Trends And Vital Rates At The Continental Scale, Paige E. Howell, Abigail J. Lawson, Kristin P. Davis, Guthrie S. Zimmerman, Orin J. Robinson, Matthew A. Boggie, Mitchell J. Eaton, Fitsum Abadi, Jessi L. Brown, Julie A. Heath, John A. Smallwood, Karen Steenhof, Ted Swem, Brian W. Rolek, Christopher J.W. Mcclure, Jean Francois Therrien, Karl E. Miller, Brian A. Millsap
American Kestrel Population Trends And Vital Rates At The Continental Scale, Paige E. Howell, Abigail J. Lawson, Kristin P. Davis, Guthrie S. Zimmerman, Orin J. Robinson, Matthew A. Boggie, Mitchell J. Eaton, Fitsum Abadi, Jessi L. Brown, Julie A. Heath, John A. Smallwood, Karen Steenhof, Ted Swem, Brian W. Rolek, Christopher J.W. Mcclure, Jean Francois Therrien, Karl E. Miller, Brian A. Millsap
Department of Biology Faculty Scholarship and Creative Works
The American kestrel (Falco sparverius, hereafter referred to as kestrel) has declined across much of its North American range since at least the mid-1960s. Kestrel population dynamics have been explored through a multitude of local studies and two broad reviews of available data. Across large geographic extents, however, the demographic cause(s) of kestrel population declines remain(s) largely unknown. As part of a collaborative effort to elucidate the drivers of kestrel population declines, we developed a continental-scale integrated population model using band-recovery data, productivity data, and Breeding Bird Survey indices from 1986 to 2019 to estimate indices of annual population sizes, …
Hold Paramount The Health, Safety, And Welfare Of The Public And The Planet, Daniel B. Oerther
Hold Paramount The Health, Safety, And Welfare Of The Public And The Planet, Daniel B. Oerther
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
No abstract provided.
Impact Of Iron-Bearing Fillers On The Mechanical Strength And Chemical Stability Of Magnesium Potassium Phosphate Matrices Incorporating Rhenium, Sergey Sayenko, Volodymyr Shkuropatenko, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Petra Ecorchard, Natalija Murafa, Iva Milisavljevic, Scott T. Misture
Impact Of Iron-Bearing Fillers On The Mechanical Strength And Chemical Stability Of Magnesium Potassium Phosphate Matrices Incorporating Rhenium, Sergey Sayenko, Volodymyr Shkuropatenko, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Petra Ecorchard, Natalija Murafa, Iva Milisavljevic, Scott T. Misture
Faculty Publications
We report on the study of the immobilization process of non-radioactive rhenium (Re), a chemical analogue of technetium-99 (99Tc), in compounds based on magnesium potassium phosphate (MKP), as well as the possibility of enhancing their properties with iron-bearing additives/fillers. Powdered Re2O7 was used as the initial Re-containing source. Because of the solubility and high leachability of Tc (VII), which is also volatile at high temperatures, its immobilization for long-term storage and disposal poses a serious challenge to researchers. Taking this into account, low-temperature stabilization technology based on MKP, a cementitious material, is currently considered promising. We prepared experimental …
4e-Bp1 Differentially Regulates Translation Of A Subset Of Human Mrnas, Mehreen Mahbub
4e-Bp1 Differentially Regulates Translation Of A Subset Of Human Mrnas, Mehreen Mahbub
Dissertations, Theses, and Capstone Projects
Elevated levels of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) influence cap-independent translation by forming a complex with eukaryotic initiation factor 4E (eIF4E) (eIF4E•4E-BP1). Certain mRNAs—including those encoding hypoxia-inducible factor-1α (HIF-1α), fibroblast growth factor-9 (FGF-9), and two isoforms of tumor suppressors, p53 (p53A, and p53B)—contain structured 5’untranslated regions (UTRs) that enable translation either via cap-independent translation enhancer (CITE)-like or internal ribosomal entry site (IRES)-like mechanisms. However, how 4E-BP1 modulates these mechanisms remains unclear. Using fluorescence-based anisotropy assays, we showed that the eIF4E•4E-BP1 binds more tightly to the 5’ m7G-cap of these mRNAs than eIF4E …
Computational And Functional Characterization Of Terebrid Venom Peptides, Favour T. Achimba
Computational And Functional Characterization Of Terebrid Venom Peptides, Favour T. Achimba
Dissertations, Theses, and Capstone Projects
Venom peptides represent a natural repertoire of bioactive compounds that are potent modulators of ion channels. Teretoxins, venom peptides from terebrid snails, remain underexplored despite their structural and functional diversity. This thesis is the first to comprehensively explore the structure and function of teretoxins using a comparative computational sequence and structure model followed by experimental assays. The majority of the functional focus has been on identifying the ion channel molecular targets of uncharacterized teretoxins. Teretoxins, like other venom peptides, are hypothesized to manipulate the cellular function of a diversity of ion channels. Dysregulation of ion channels leads to several …
Less Self, Less Fear: Manipulation Of The Self Using Virtual Out-Of-Body Experiences To Alter The Conscious And Unconscious Experience Of Emotion, Dillon Freed
Dissertations, Theses, and Capstone Projects
This study investigated whether adopting an out-of-body perspective in virtual reality (VR) reduces subjective and physiological emotional responses to vicarious pain stimuli compared to inhabiting a first-person embodied avatar. Twenty-four participants experienced two counterbalanced VR conditions: (1) Avatar Embodiment (AV), in which they inhabited a photorealistic avatar from a first-person perspective, and (2) a Virtual Out-of-Body Experience (vOBE), in which they observed their avatar from a displaced third-person perspective. In both conditions, participants viewed a standardized series of vicarious pain images while electrodermal activity was recorded and self-report measures of embodiment (AV) and disembodiment (the vOBE state), emotional intensity (a …
Protein Allostery Probed By Ligands Across Sites, Virgil A. Woods
Protein Allostery Probed By Ligands Across Sites, Virgil A. Woods
Dissertations, Theses, and Capstone Projects
Allostery is a pervasive regulatory principle throughout biology, yet the structural pathways by which distal inputs alter active‑site chemistry within protein structures remain incompletely defined and exploited. This dissertation uses protein tyrosine phosphatase 1B (PTP1B) as a tractable model to map those pathways with complementary experimental and computational tools. I integrate high‑resolution hydrogen-deuterium exchange mass spectrometry (HDX-MS), room-temperature crystallography, NMR, steady-state kinetics, crystallographic pseudo-ensembles, and machine-learning-guided ligand discovery. The working premise is that regulation reflects redistribution within a conformational ensemble rather than a binary switch. That orthogonal perturbations by small molecules, mutations, and protein partners can be used to both …
How To Search For The Engram: Optogenetics And Network Dynamics, Claudia Garcia Jou
How To Search For The Engram: Optogenetics And Network Dynamics, Claudia Garcia Jou
Dissertations, Theses, and Capstone Projects
Memories are thought to be encoded by ensembles of neurons called "engram cells", because their artificial activation with optogenetics leads to the behavioral expression of a memory. However, the physiological mechanisms that mediate this process remain unknown. In this thesis, I investigate how optogenetic stimulation of memory-tagged cells changes neuronal firing, spatial coding, and the geometry of neural manifolds. I used an active place avoidance task and a foraging task to label engram cells in the dorsal hippocampus with Channelrhodopsin2 (ChR2). I then recorded the hippocampal activity response to optogenetic stimulation in mice under anesthesia, head-fixed, or freely moving. I …
Dissolved Organic Matter Composition In The Laurentian Great Lakes Ice And Its Contribution To Spring Melt, Anthony J. Arsenault, Nolan J.T. Pearce, Ted Ozersky, Sarah C. D’Amario, Kirill Shchapov, Hunter J. Carrick, Trista Vick-Majors, Et Al.
Dissolved Organic Matter Composition In The Laurentian Great Lakes Ice And Its Contribution To Spring Melt, Anthony J. Arsenault, Nolan J.T. Pearce, Ted Ozersky, Sarah C. D’Amario, Kirill Shchapov, Hunter J. Carrick, Trista Vick-Majors, Et Al.
Michigan Tech Publications
Dissolved organic matter (DOM) plays a vital role in lakes, but its behavior in winter is poorly understood. This study examined the differences in DOM between lake ice and the upper water column across 18 sites in the Laurentian Great Lakes, integrating in situ sampling and remotely sensed ice data to create a mass budget model to estimate basin-scale DOM storage and release from ice. We found that the composition of the DOM pool in ice varied based on ice thickness, water DOM composition, nutrients, and dissolved organic carbon concentrations. Calculations of protein-like, microbial humic-like, and terrestrial-like DOM storage in …
Genomic Comparisons And The Adaptive Basis Of Brain Size Plasticity And Chromosomal Instability In The Eurasian Common Shrew, William R. Thomas, Tanya M. Lama, Cecilia Baldoni, Laia Marín-Gual, Diana Moreno Santillán, Marta Farré, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Ying Sims, Alan Tracey, Jo Wood, David A. Ray, Dominik Von Elverfeldt, John Nieland, Angelique P. Corthals, Aurora Ruiz-Herrera, Dina K.N. Dechmann, Erich Jarvis, Liliana M. Dávalos
Genomic Comparisons And The Adaptive Basis Of Brain Size Plasticity And Chromosomal Instability In The Eurasian Common Shrew, William R. Thomas, Tanya M. Lama, Cecilia Baldoni, Laia Marín-Gual, Diana Moreno Santillán, Marta Farré, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Ying Sims, Alan Tracey, Jo Wood, David A. Ray, Dominik Von Elverfeldt, John Nieland, Angelique P. Corthals, Aurora Ruiz-Herrera, Dina K.N. Dechmann, Erich Jarvis, Liliana M. Dávalos
Biological Sciences: Faculty Publications
Sorex araneus, the Eurasian common shrew, has seasonal brain size plasticity (Dehnel's phenomenon) and many intraspecific chromosomal rearrangements. Genomic contributions to these traits, however, remain unknown. We couple a chromosome-scale genome assembly with seasonal brain transcriptomes to discover relationships between molecular evolution and both traits. While Positively Selected Genes (PSGs) enriched the Fanconi anemia DNA repair pathway (FANCI, FAAP100), which is likely involved in chromosomal rearrangements by preventing the accumulation of chromosomal aberrations, genes under positive selection or showing seasonal differential expression in the brain implicate neurogenesis (PCDHA6, SOX9, Notch signaling) and metabolic regulation (VEGFA, SPHK2) as key mechanisms underlying …
Vultures, Bryan M. Kluever, Lee A. Humberg, Scott C. Barras
Vultures, Bryan M. Kluever, Lee A. Humberg, Scott C. Barras
Wildlife Damage Management Technical Series
Fact sheet about vultures including information about human--wildlife conflicts, the vulture roost, affects on livestock, structures, human health and safety, identification of damage, management methods, legal considerations, and economics. Also included is an overview of the species.
Dna Stability In Aqueous Solutions: A Case Study On Poly A - Poly T Duplex Using Molecular Dynamics Simulations, Haripriya Chennuru
Dna Stability In Aqueous Solutions: A Case Study On Poly A - Poly T Duplex Using Molecular Dynamics Simulations, Haripriya Chennuru
Biochemistry and Molecular Biology
This thesis relies on molecular dynamics (MD) simulations, which apply the AMBER software package to analyze the structural stability, energetics, and dynamics of Poly A - Poly T DNA duplexes. This work is mainly concerned with testing configurations of non-bonded interaction cutoffs (12 Å and 15 Å) on the Generalized Born solvation models (IGB1 and IGB2) to determine the most appropriate conditions regarding computation time and physical reliability in DNA molecular dynamics. The solvation models enable effective simulation of solvent effects, facilitating the calculation of simulation parameters to evaluate structural stability within different environmental conditions. Overall, the performance indicates that …
Obesity Does Not Significantly Impact Clinical Outcomes Following Anterior Cervical Discectomy And Fusion, Ishan Shah, Alejandro Perez-Albela, Riya Shah, Charles Furlong, Puru Sadh, John Czerwein, Alan Daniels, Bryce A Basques
Obesity Does Not Significantly Impact Clinical Outcomes Following Anterior Cervical Discectomy And Fusion, Ishan Shah, Alejandro Perez-Albela, Riya Shah, Charles Furlong, Puru Sadh, John Czerwein, Alan Daniels, Bryce A Basques
SKMC Student Presentations and Publications
BACKGROUND: With obesity rates rising among patients undergoing anterior cervical discectomy and fusion (ACDF) and more procedures shifting to outpatient settings, this study aimed to evaluate the impact of body mass index (BMI) on complications, sagittal alignment, and patient-reported outcomes (PROs).
METHODS: A prospectively maintained database of 302 patients who underwent ACDF for myelopathy or radiculopathy between 2020 and 2022 at a single academic center was analyzed. Patients were stratified into four BMI categories: normal (18.5-< 25), overweight (25-< 30), obese class I (30-< 35), and obese class II/III (≥35). Collected data included demographics, comorbidities, perioperative variables, radiographic measures (cSVA, Cobb angle, etc.), and PROs (VAS, NDI). Univariate regression compared demographics, alignment, and PROs, while multivariate analyses assessed complications and perioperative factors.
RESULTS: BMI was not independently associated with higher rates of postoperative complications, including adjacent segment disease, subsidence, reoperation, or other adverse events. Patients in …
Status Of The Western Australian Pastoral Rangelands 2025 - Total Vegetative Cover And Cover Risk, Department Of Primary Industries And Regional Development, Western Australia
Status Of The Western Australian Pastoral Rangelands 2025 - Total Vegetative Cover And Cover Risk, Department Of Primary Industries And Regional Development, Western Australia
Natural resources published reports
DPIRD monitors and reports on the vegetation condition of pastoral rangelands in Western Australia. Two levels of reporting are provided: every 5 years a full report details the state, trend and risk of decrease of vegetation condition in the pastoral rangelands using information derived from remotely sensed and on-ground data; in the intervening years, short reports are provided based on remotely sensed data (this report).
This report is based on remotely sensed vegetation cover data, rainfall data, livestock data and station-level rangeland condition assessment (RCA) data available in November 2025. Data is presented for 23 land conservation districts (LCDs) across …
Local Angiotensin Converting Enzyme 2 (Ace2) Enzymatic Activity Modulates Cholinergic Interneuron Function In The Dorsolateral Striatum, Aria R. Walls
Local Angiotensin Converting Enzyme 2 (Ace2) Enzymatic Activity Modulates Cholinergic Interneuron Function In The Dorsolateral Striatum, Aria R. Walls
Dissertations, Theses, and Capstone Projects
The renin angiotensin system (RAS) is an ancestrally ancient peptidergic signaling pathway best known for its role regulating blood pressure in the periphery. However, its presence and importance in the central nervous system has more recently been identified and is less well understood. Previous work shows RAS is expressed in the nigrostriatal pathway of the basal ganglia and has been implicated in basal ganglia disorders including Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID). Interestingly, the canonical and noncanonical arms of the RAS pathway produce opposite effects on PD disease vulnerability and progression. The shift from the neurodegenerative canonical RAS to …
Monosaccharide Binding To Synthetic Carbohydrate Receptor Microarrays, Milan A. Shlain
Monosaccharide Binding To Synthetic Carbohydrate Receptor Microarrays, Milan A. Shlain
Dissertations, Theses, and Capstone Projects
Chapter 1: A glycan detection platform comprised of synthetic carbohydrate receptors (SCRs) immobilized onto polymer brushes was prepared. SCR043, an alkene-containing SCR, was incorporated into grafted-from polymer brushes using hypersurface photolithography, resulting in microarrays of SCR043-functionalized polymer brushes, where brush height (h) and SCR grafting density (Γ) is controlled precisely at each feature in the array. The influence of h and Γ on the binding to five fluorescently labelled monosaccharides – α-glucose (α-Gluc-FL), α-galactose (α-Gal-FL), α-mannose (α-Man-FL), β-glucose (β-Gluc-FL), and β-galactose (β-Gal-FL) – in aqueous buffer …
Somatosensory Cortex Responses To Illusory Touch In A Visual-Tactile Integration Task, Aditi Surendra Pawar
Somatosensory Cortex Responses To Illusory Touch In A Visual-Tactile Integration Task, Aditi Surendra Pawar
Dissertations, Theses, and Capstone Projects
Perceptual illusions arising from multisensory integration reveal how the brain constructs subjective experience from sensory input, and provide a powerful means of allowing the investigation of neural processes that track perceptual interpretation rather than physical stimulation alone. While visual illusions induced by auditory or tactile stimuli have been fairly well studied, the neural mechanisms underlying visually-induced illusory touch remain unclear. This study investigated whether illusory tactile perception engages the somatosensory cortex in a manner similar to veridical touch. Twenty healthy adults participated in an event-related functional magnetic resonance imaging (fMRI) study while performing a tactile numerosity judgment task. Each trial …
Anthelmintic Efficacy Of Rosemary Oil And Its Nanoemulsion Against The Monogenean Parasite, Zeuxapta Seriolae, In Yellowtail Kingfish (Seriola Lalandi), Md Reaz Chaklader, Lindsey Woolley, Hosna Gholipour-Kanani, Masashi Maita, Gavin Partridge
Anthelmintic Efficacy Of Rosemary Oil And Its Nanoemulsion Against The Monogenean Parasite, Zeuxapta Seriolae, In Yellowtail Kingfish (Seriola Lalandi), Md Reaz Chaklader, Lindsey Woolley, Hosna Gholipour-Kanani, Masashi Maita, Gavin Partridge
Fisheries Research Articles
This study evaluated the anthelmintic efficacy of rosemary oil delivered as a nanoemulsion compared with regular rosemary oil against the monogenean parasite Zeuxapta seriolae in yellowtail kingfish (YTK; Seriola lalandi). A 20-day feeding trial tested three dietary treatments: two levels of regular rosemary oil (providing 0.85 and 1.7 g cineole·kg−1 feed) and a rosemary-oil nanoemulsion (providing 0.85 g cineole·kg−1 feed), against a control diet without rosemary oil. Juvenile fish (293 ± 5 g) were pre-exposed to Z. seriolae oncomiracidia before the trial, resulting in an initial mean parasite abundance of 97 ± 4 per fish. At trial completion, plasma …
Uncovering Predictors Of Bipolar Ii Conversion To Bipolar I: A Machine Learning Analysis Of National Health Records In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Kuo-Chuan Hung, Mu-Hong Chen, Eduard Vieta, Chien-Yuan Chen, Chih-Sung Liang, Andre F Carvalho
Uncovering Predictors Of Bipolar Ii Conversion To Bipolar I: A Machine Learning Analysis Of National Health Records In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Kuo-Chuan Hung, Mu-Hong Chen, Eduard Vieta, Chien-Yuan Chen, Chih-Sung Liang, Andre F Carvalho
Children’s Nutrition Research Center Staff Publications
Background: Bipolar II disorder (BD-II) can progress to bipolar I disorder (BD-I), carrying profound psychosocial consequences. However, limited research has investigated the transition from BD-II to BD-I. Our study uses machine learning to predict the conversion using real-world data.
Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database (2000-2013) to identify adults diagnosed with BD-II. A predictive model for BD-I conversion was developed using extreme gradient boosting (XGBoost), incorporating demographic factors, healthcare utilization, comorbidities, and psychotropic medication use. The dataset was randomly divided into development (80 %) and test (20 %) sets. Model performance …
Catatonia And Elevated Mortality: A Population-Wide Cohort Study With Healthy, Sibling, And Schizophrenia Spectrum Controls, Chih-Wei Hsu, Yang-Chieh Brian Chen, Marco Solmi, Chih-Sung Liang, Mu-Hong Chen, Yao-Hsu Yang, Liang-Jen Wang, Edward Chia-Cheng Lai
Catatonia And Elevated Mortality: A Population-Wide Cohort Study With Healthy, Sibling, And Schizophrenia Spectrum Controls, Chih-Wei Hsu, Yang-Chieh Brian Chen, Marco Solmi, Chih-Sung Liang, Mu-Hong Chen, Yao-Hsu Yang, Liang-Jen Wang, Edward Chia-Cheng Lai
Children’s Nutrition Research Center Staff Publications
Aim: To determine whether catatonia is associated with increased long-term all-cause and cause-specific mortality.
Methods: Using Taiwan's National Health Insurance Database (2000-2022), we assembled a population-based cohort of all adults (≥18 years) with catatonia and matched each to four controls without catatonia on sex and birthdate. Mortality was compared between (1) individuals with catatonia and their unaffected siblings and (2) individuals with schizophrenia spectrum disorders with catatonia and those with schizophrenia spectrum disorders without catatonia. The primary outcome was all-cause mortality; secondary outcomes were natural- and unnatural-cause deaths. Adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated with …
Cellscout: Visual Analytics For Mining Biomarkers In Cell State Discovery, Rui Sheng, Zelin Zang, Jiachen Wang, Yan Luo, Zixin Chen, Yan Zhou, Shaolun Ruan, Huamin Qu
Cellscout: Visual Analytics For Mining Biomarkers In Cell State Discovery, Rui Sheng, Zelin Zang, Jiachen Wang, Yan Luo, Zixin Chen, Yan Zhou, Shaolun Ruan, Huamin Qu
Research Collection School Of Computing and Information Systems
Cell state discovery is crucial for understanding biological systems and enhancing medical outcomes. A key aspect of this process is identifying distinct biomarkers that define specific cell states. However, difficulties arise from the co-discovery process of cell states and biomarkers: biologists often use dimensionality reduction to visualize cells in a two-dimensional space. Then they usually interpret visually clustered cells as distinct states, from which they seek to identify unique biomarkers. However, this assumption is often this assumption often fails to hold due to internal inconsistencies in a cluster, making the process trial-and-error and highly uncertain. Therefore, biologists urgently need effective …
Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen J. Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael W. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael G. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson
Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen J. Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael W. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael G. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson
Research outputs 2022 to 2026
Adverse fire regimes threaten biodiversity, potentially leading to population declines and increased extinction risk. Understanding how varying fire regimes affect threatened species is essential for effective ecosystem management, including in Western Australia where diverse ecosystems are exposed to wildfires, Indigenous burning, and prescribed fire. We compiled and synthesised data on the threat of adverse fire regimes to threatened animal taxa in Western Australia. Using a threat classification scheme, we ranked adverse fire regimes as having either no, low, medium, high, or unknown impact on each taxon. A total of 212 taxa were reviewed, 153 (72%) of which are considered fire-threatened: …