Digital Commons Network^™

Seismic Behavior Of Slender Cable-Supported Braced Frame Structures, Aya Aboelnaga, Mohamed Mortagi, Mohamed E. El Madawy, A.H.A. Abdelrahman, M. Naguib

Mansoura Engineering Journal

This research investigates advanced strategies to enhance the seismic performance and global stability of slender steel frames by integrating cable-supported and braced systems. To address these challenges, the study develops finite element (FE) models of multi-story slender frames in SAP2000, incorporating both cable-supported configurations and diagonal bracing systems. Nonlinear time-history analyses are performed using selected earthquake ground motions to evaluate structural response, inter-story drift, and mode shape behavior. Results highlight the efficiency of cablesupported frames in controlling lateral displacements and redistributing forces, while also emphasizing the role of bracing in providing additional stiffness. The findings demonstrate that guided frames with …

Neuproio: A Dual-Action Solid Drug Nanoparticle Topical Formulation For Simultaneous Intraocular Pressure Reduction And Neuroprotection For Glaucoma, Lei Xu, Mu Li, Lin Qi, Tzu Chen Wang, Dong Liu, Vimalin Jeyalatha Mani, Hsin Yin Chuang, Qingbo Yang, Ruipu Mu, Samira Mahdi, Da Huang, Honglan Shi, Yang Hu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glaucoma is a leading cause of irreversible blindness, primarily due to elevated intraocular pressure (IOP) that damages the retina and optic nerve. Most topical glaucoma treatments focus solely on IOP-lowering without direct neuroprotection, as drug delivery to the posterior eye is challenging. Here, we developed NeuProIO, a dual-action solid drug nanoparticle (NP) eye drop for simultaneous IOP reduction and neuroprotection. Using flash nanoprecipitation in a multi-inlet vortex mixer, we fabricated the first NeuProIO solid drug NPs incorporating the repurposed neuroprotective agent maprotiline (MAP) and the IOP-lowering agent betaxolol (BX), forming MAP/BX NPs for synergistic glaucoma treatment. The NeuProIO improved stability …

Observations Of Puddling Butterflies In Maryland, Usa, Aydin Örstan

The Taxonomic Report of the International Lepidoptera Survey

Six butterfly species in four families were observed puddling on damp soil, scat and carrion in various locations in Montgomery County, Maryland and on small islands in the Potomac River. Four species preferred damp soil to nearby mud, but the reason for this behavior is unknown. The presence of butterflies on small islands in the Potomac River is documented for the first time.

Optimizing Electrode Placement And Information Capacity For Local Field Potentials In Cortex, Jace A Willis, Christopher E Wright, Ruoqian Zhu, Yilan Ruan, Joshua Stallings, Amada M Abrego, Takfarinas Medani, Promit Moitra, Arjun Ramakrishnan, Charles E Schroeder, Anand A Joshi, Nitin Tandon, Richard M Leahy, John C Mosher, John P Seymour

Faculty, Staff and Student Publications

Recent neurosurgery advancements include improved stereotactic targeting and increased density and specificity of electrophysiological evaluation. This study introduces a subject-specific, in silico modeling tool for optimizing electrode placement and maximizing coverage with a variety of devices. The basis for optimization is the Shannon-Hartley information capacity of field potentials derived from dipolar sources. The approach integrates subject-specific MRI data with finite element modeling (FEM) used to simulate the sensitivity of subdural and intracortical devices. Sensitivity maps, or lead fields, from these models enable the comparison of different electrode placements, contact sizes, contact configurations, and substrate properties, which are often overlooked factors. …

Clinical, Genetic, And Familial Features Of Pot1 Tumor Predisposition Syndrome, Courtney D Dinardo, Jennifer Croden, Hiam M Abdel-Salam, Tapan Kadia, Matteo Molica, Alexandre Bazinet, Prithviraj Bose, Abhishek Maiti, Fadi Haddad, Jan Burger, Hagop Kantarjian, William Wierda, Nitin Jain, Alessandra Ferrajoli

Faculty, Staff and Student Publications

Background: Protection of telomere 1 (POT1) tumor predisposition syndrome (POT1-TPD) is a hereditary leukemia syndrome that is identified in ∼5% of patients with chronic lymphocytic leukemia (CLL) and is characterized by a predisposition to other cancers, including gliomas, melanomas, and angiosarcomas. This study reports clinical and genetic characteristics of a large cohort of individuals with POT1-TPD.

Materials and methods: Individuals with pathogenic/likely pathogenic germline POT1 variants referred to the Hereditary Hematologic Malignancy Clinic at The University of Texas MD Anderson Cancer Center were included. Individuals with variants of uncertain significance were included if found to have telomeres >90th percentile of …

Control Arm Overperformance In Phase 3 Oncology Clinical Trials, Ansel P Nalin, Pavlos Msaouel, Adam J Grippin, Ramez Kouzy, Joseph Abi Jaoude, Timothy A Lin, Avital M Miller, Noah S Meimoun, Ethan B Ludmir, Alexander D Sherry

Faculty, Staff and Student Publications

Background: In randomized clinical trials (RCTs), anticipating control arm outcomes is important for power calculations and enrollment goals. Unexpected overperformance of the control arm can underpower RCTs. The objective of this study was to estimate the prevalence of control arm overperformance in phase 3 oncology RCTs.

Methods: The authors conducted a meta-epidemiological study of two-arm, superiority-design, phase 3 oncology RCTs. They reviewed articles/publications and protocols for power calculations, justification, and outcomes. Control arm performance was measured as the ratio of observed control arm outcomes relative to pretrial estimates, and overperformance was defined as a 10% improvement.

Results: In total, 385 …

Antidepressant Use In Older Age Bipolar Disorder (Oabd): Results From The Gage-Bd International Consortium, Christina Rigas, Paola Lavin, P J Chen, Susana G Torres-Platas, Chien-Lin Su, Lisa T Eyler, Andrew T Olagunju, Antonio L Teixeira, Annemieke Dols, Martin Alda, Osvaldo P Almeida, Kursat Altinbas, Vicent Balanzá-Martínez, Izabela G Barbosa, Hilary P Blumberg, Farren B S Briggs, Cynthia V Calkin, Brent P Forester, Orestes V Forlenza, Tomas Hajek, Barthomeus C M Haarman, Esther Jimenez, Beny Lafer, Benoit Mulsant, Stephen O Oluwaniyi, Regan Patrick, Joaquim Radua, Kaylee Sarna, Sigfried Schouws, Christian Simhandl, Jair C Soares, Ashley N Sutherland, Shang-Ying Tsai, Eduard Vieta, Luca M Villa, Nicole Fiorelli, Paula Villela Nunes, Joy M Yala, Martha Sajatovic, Soham Rej, All Gage-Bd Investigators

Faculty, Staff and Student Publications

Background: Antidepressants are still commonly prescribed in bipolar disorders, despite ongoing controversy of the potential risk of inducing hypomania/mania. There is limited knowledge about the characteristics of antidepressant use in older age bipolar disorder (OABD; age ≥50) in the current literature.

Aim: To describe antidepressant use, sociodemographic and clinical correlates of a global sample of OABD individuals.

Methods: The Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) consortium provided cross-sectional international data on OABD individuals (n = 746) and younger-age bipolar disorder (YABD, age < 50 years; n = 692) regarding antidepressant use. Multivariate logistic regression was employed to assess the association between AD use with demographic and clinical variables.

Results: Of 1252 participants, 33.1 % of OABD individuals and 38.1 % of YABD individuals …

Human Versus Machine: Can Generative Ai Anticipate Insect Biological Control Outcomes?, Kris A.G. Wyckhuys, Komivi S. Akutse, Divina M. Amalin, Salah Eddin Araj, Marie Joy B. Beltran, Ibtissem Ben Fekih, Paul André Calatayud, Lizette Cicero, Marcellin C. Cokola, Yelitza C. Colmenarez, Kenza Dessauvages, Thomas Dubois, Léna Durocher-Granger, José L. Fernández-Triana, Frederic Francis, Khalid Haddi, Rhett D. Harrison, Muhammad Haseeb, Natasha S.A. Iwanicki

All Peer-Reviewed Publications

Generative artificial intelligence (AI) could transform evidence synthesis and revolutionize the global scientific enterprise, yet its agricultural applications are understudied. Here, we systematically assess the performance of three web-grounded AI engines (ChatGPT, ScholarAI and DeepSeek) in synthesizing the global literature on biological control of the fall armyworm Spodoptera frugiperda, and benchmark their outputs against a recent, near-exhaustive human review. Though all engines rapidly screened vast literature corpora, they exhibited shortcomings in factual accuracy, reporting reliability and data consistency. In machine-run syntheses, natural enemy prevalence and performance data often diverged from published records while the level of agreement in enumerating top-performing …

Mechanized Tube Well Installation, Robert M. Stwalley Iii, Grace L. Baldwin Kan-Uge, Roger Tormoehlen

Purdue University Press Books

Mechanized Tube Well Installation provides detailed information on the design development of a mechanized means to install shallow tube wells using a hydraulic driver attached to a small vehicle. This book explores the creation of this technique through the merging of available components, selection of the components, testing of the assembly, and the driving of wells. It also provides comprehensive coverage of state-of-the-art engineering, technology, and best practices as they relate to driving water wells for human consumption, animal care, and irrigation. Mechanized Tube Well Installation is well-aligned with collegiate humanitarian aid, environmental and natural resources engineering, and agricultural equipment …

Applied Research For Corn Production In Indiana, 2022, Daniel Quinn

Purdue University Press Books

The 2022 edition of Applied Research for Corn Production in Indiana offers accessible, research-based tips for farmers who want to improve corn production practices by using applied field-research trials. Daniel Quinn and the Purdue University Corn Agronomy team reveal practical ways to boost yields, reduce costs, and improve sustainability on the farm. Their findings are derived from applied research trials across the state and relate to important topics such as planting practices, fertilizer use, crop nutrition, cover crops, and new technologies. Applied Research for Corn Production in Indiana distills complex research into clear insights and supplies corn producers with effective …

Advanced Design Topics For The Engineering Of Agricultural And Mechanical Equipment, Robert M. Stwalley Iii, Roger Tormoehlen

Purdue University Press Books

Off-road equipment designs contend with some unusual challenges and environmental conditions that are not seen by standard on-road vehicles. Advanced Design Topics for the Engineering of Agricultural and Mechanical Equipment offers design topic reviews related to areas that need special consideration within off-road applications. CAN-BUS systems, soil compaction, composite bearings, field welding practices, and weld strength in bending applications are examined, among other subjects. Providing comprehensive coverage of these matters with the current state-of-the-art technologies and best practices as they relate to equipment design for the agricultural, construction, forestry, and mining industries, this book is well-aligned with collegiate advanced agricultural …

Protocols In Root-Microbe Interactions, Anjali S. Iyer-Pascuzzi

Purdue University Press Books

Protocols in Root-Microbe Interactions describes laboratory protocols that have been developed and optimized for scientists working in root-microbe interactions, specifically for those wanting to quantify immune responses in plant roots. The experiments are focused on cellular to whole-root scale and include molecular biology, biochemistry, and histology techniques. Written in an easy-to-understand fashion that is suitable for both early career and experienced scientists, the protocols were optimized for tomato roots but can easily be adapted to roots of other plant species, or if needed, to leaves. The book includes information on quantifying pattern-triggered immune (PTI) responses in plant roots and covers …

Horse Evaluation: A Multibreed Text For Competitive Youth Equine Judges, Colleen M. Brady

Purdue University Press Books

Horse judging is one of the most popular activities in 4-H, FFA, and other youth-development organizations. Judging teaches youth how to both critically analyze animals based on a specific set of criteria and justify their decisions through oral reasoning. This book includes information on examining a wide variety of breeds—from quarter horses and Arabians to Saddlebreds, Drafts, and Miniatures—and covers a range of disciplines. Both halter and performance classes are explored, and the rules and regulations used to govern contests at the national level are provided. Example sets of reasons are supplied for most classes, as are lists of potential …

Metagenomic Profiling Of Gut Microbiome Signatures Across Liver Disease Stages And Hcv-Related Hepatocellular Carcinoma In Egyptian Patients, Marwa A. Zahra

Theses and Dissertations

Dysbiosis in the gut microbiome, particularly concerning the synchronous crosstalk between the gut and the liver, has been associated with various diseases. This study profiles the gut microbiome in liver diseases among Egyptian patients, with a focus on the hepatitis C virus (HCV) and hepatocellular carcinoma (HCC), both of which are highly prevalent in Egypt. Utilizing shotgun metagenomic sequencing, we analyzed microbial gene catalogs and taxonomic profiles from 46 Egyptian patients categorized into five groups: healthy individuals, liver disease patients of different etiologies, post-HCV, treated HCV, and HCV-HCC patients. Healthy and treated HCV patients exhibited distinct microbial profiles characterized by …

A Proposed Vision To Activate Smart Urban Growth Concepts For The New Egyptian Cities, Nirman M. El-Sayed, Mamdouh A. Al-Minshawi

Mansoura Engineering Journal

Smart urban growth is the ideal solution to urban problems within the cities of the fourth generation in Egypt, and despite this, most of them depend on traditional urban thought without activating "Smart Urban Growth", which is known to maintain lands from deterioration and make societies suitable for living and providing the necessary services. The goal of research to set standards to activate smart urban growth as a thought that keeps pace with sustainable urban development and Egypt's 2030 vision, work to use the global smart cities approach and how they reach intelligence. While the research follows the "analytical" deductive …

Charting A New Era To Modernize United States Infant Formula Regulation, Douglas G Burrin, Amy B Hair, Sharon M Donovan

Children’s Nutrition Research Center Staff Publications

No abstract provided.

Investigation Of Biofilm Formation And Osmotic Stress Tolerance Of Nonmotile E. Coli Mg1655 In Simulated Microgravity, Tyler Jenkins

Student Research Symposium (SRS)

Simulated microgravity presents multiple physiological stressors for astronauts, including bone demineralization, muscle loss, and weakening of the immune system (Chavez et al., 2024). Bacteria serve as viable model organisms to study physiological changes because of their abundance in the human digestive system and skin. Motility in bacteria plays a significant role in cell survival, but few studies have been conducted on microgravity’s effect on motility phenotypes. While motile strains like K12 have been studied extensively under microgravity conditions (Topolski et al., 2022; Chavez et al., 2024), the effects of simulated microgravity on non-motile strains are largely unknown. To better understand …

Development Of An Ied Response Model For Testing Of The Snapping Shrimp Resource Allocation Algorithm, Joanna Morris

Student Research Symposium (SRS)

"Models must be capable of demonstrating adaptability across multiple case studies to confirm their reliability and versatility. The Snapping Shrimp Resource Allocation Algorithm, which has been successfully applied in a wildfire response scenario, models efficient, decentralized coordination inspired by the behavior of snapping shrimp. Building on this foundation, the current work explores the potential application of the Snapping Shrimp Resource Allocation algorithm to improvised explosive device response where rapid, autonomous coordination could significantly enhance safety and operational efficiency. Improvised explosive devices remain a persistent issue in modern conflict, requiring strategies for response that are cost-effective, scalable, and capable of adapting …

Leo Ii...A Remembrance, The Flor-Ala

Documents

A special edition issue of The Flor-Ala in remembrance of Leo II.

New Honor For Leo Ii: May Be First In Nation, Cheri Shipper, Dr. J. R. Holladay, Dr. Wayne Cotton

Documents

This news release announces the exciting news that Leo II was selected as "Honorary ChairAnimal for National Pet Week" May 7-13 in the Shoals.

Tv Helps Leo Overcome Boredom, Karen Jackson

Documents

TV always makes people (and animals) happy!

*Article from The TimesDaily*

See The Lion At Una, Vacation Guide

Documents

A short write-up about the only African lion which serves as a school mascot-Leo II.

King Of The Jungle, Scott Burcham/Staff

Documents

Leo II playing with his new toy pig on the eve of UNA's game against Texas A & M Kingsville in Florence.

Leo I Versus Leo Ii, Dr. Joe Wallace

Documents

Personal account of Leo I versus Leo II written by Dr. Joe Wallace in Shoal Magazine.

Lion Talk: Vocabulary 101, Elise Cofield

Documents

Information about the Lions Fund at the University of North Alabama in the Spring edition of the UNA Magazine.

Leo Ii's Passing Leaves Large Void Around Una Campus, Una Sports Information

Documents

A fitting tribute to Leo II in the Lion's Roar.

The Story Of Leo The Lion, Joe Wallace

Documents

This souvenir edition magazine details the relationship between author Joe Wallace and Leo I at UNA.

Watching Our Family Grow, Una Magazine

Documents

A typical day for 10 months old Leo III and Una at the George H. Carroll Lion Habitat.

The Pride Of Una, Michelle Rupe Eubanks

Documents

Fun facts about Leo III and Una.

Una's Leo Put To Sleep, Lori Allen Dendy

Documents

Breaking the news that Leo I has passed away at 14 years old.

*Article from The TimesDaily. *