Digital Commons Network^™

The Next Gold Rush May Be In The Stars, Ned Markham

Osmosis Magazine

No abstract provided.

The Mind Of A Killer: Traumatic Brain Injury & The Roots Of Extreme Violence, Natasha Troike

Osmosis Magazine

No abstract provided.

How Do Vaccines Work?, Natalie Small

Osmosis Magazine

No abstract provided.

Living With Pets: The Science Behind Immune Development, Mitchell Wood

Osmosis Magazine

No abstract provided.

A Tale As Old As Time: Experimental Evidence For The Big Bang Theory, Michael Bo

Osmosis Magazine

No abstract provided.

Seeing The Future: How Chemically Modified Vitamin A Slows Blindness, Marty Snyder

Osmosis Magazine

No abstract provided.

Nicotine Without Smoke: What Oral Pouches Really Mean For Heal, Luke Surrusco

Osmosis Magazine

No abstract provided.

Where’S The Spark?: The Mystery Of Eel Reproduction, Lily Cashen

Osmosis Magazine

No abstract provided.

The Hidden Cost Of Compassion In Veterinary Medicine, Lauren Dugger

Osmosis Magazine

No abstract provided.

Will A Robot Be Your Next Dentist?, Garrett Mayover

Osmosis Magazine

No abstract provided.

An Unfiltered View Of Skincare: Causes Of And Cures For Acne, Eve Snyder

Osmosis Magazine

No abstract provided.

Fixing The Mind By Breaking It: The Lobotomy Era, Erlinda Sali

Osmosis Magazine

No abstract provided.

Relaxin: Could This Pregnancy Hormone Be A Cure-All?, Eloen Beebee

Osmosis Magazine

No abstract provided.

Plasma And Profit: Hidden Economics Of Vital Medicine, Dylan Prinster

Osmosis Magazine

No abstract provided.

World War Ant, Connor Beasley

Osmosis Magazine

No abstract provided.

Milk-Fed Astronauts In A Microbial Galaxy, Charlie Lanning

Osmosis Magazine

No abstract provided.

Where’S Perry? The Strange Biology Of The Platypus, Carolina Mosquera

Osmosis Magazine

No abstract provided.

Is Artifical Intelligence "Truly" Intelligent?, Camila Nicole Valdman

Osmosis Magazine

No abstract provided.

Nanotyrannus: A New Dinosaur Or Baby T. Rex?, Bryan Nam

Osmosis Magazine

No abstract provided.

What's In Tuburculosis, That Which We Call 'Chic?', Ainsley Coleman

Osmosis Magazine

No abstract provided.

Letter From The Editor, Eliz Ustun

Osmosis Magazine

No abstract provided.

Osmosis - Science Magazine

Osmosis Magazine

Big Questions -- Real Science -- New Ideas

Rna Interference Targeting Autocrine Motility Factor Receptor In Unfolded Protein Response In Acyrthosiphon Pisum, Micah A. Von Stroh, James Balthazor

SACAD: Scholarly Activities

Acyrthosiphon pisum, more commonly known as pea aphids, are a pest to many species of Fabaceae (legumes) mainly due to the species being prone to carrying Fabaceae diseases. Protection against A. pisum currently includes insecticides and natural predators, both of which bring potential negative effects to other organisms in the surrounding area. In this study, the use of RNA interference (RNAi) provides an alternative and species-specific elimination of A. pisum. The targeted proteins in this study, Autocrine Motility Factor Receptor, plays a role in removing misfolded proteins from the cells of A. Pisum and is encoded by the AMFR gene. …

Atp Architect - Development Of A Metabolism Boardgame, Selene J. Welch, Micah Burk, Brooklyn Gilchrist, Emma Haase, Timothy T. Jones

SACAD: Scholarly Activities

Traditional metabolism instruction often leaves students struggling with pathway interconnectedness and metabolite flux. To foster systems thinking, we are developing an educational board game where students manipulate tokens to navigate physiological constraints and achieve target energy goals. Grounded in Design-Based Research (DBR), the game undergoes iterative refinement based on player feedback. The design utilizes constructivism by allowing students to "fail safely" and revise strategies in real-time, while leveraging embodied cognition to externalize abstract flux into the physical trading of resource tokens.

Structural Transformation Of A Hydrogel-Forming Cell Division Protein Zapb Of Multidrug Resistant Klebsiella Pneumoniae With Small Molecules, Ayesha Khan, M. Iqbal Choudhary, Sumaira Javaid, Humaira Zafar, Innokentiy Maslennikov, Atia-Tul Wahab

Pharmacy Faculty Articles and Research

Septal ring assembly protein ZapB (EMR18431.1) is involved in Z-ring formation, and nucleoid segregation during the bacterial cell division . It promotes cell division in the initial stages of the cell cycle through direct interaction with FtsZ, thus stimulating Z-ring assembly. The ZapB inhibition can make bacterial cell susceptible to primary antibiotics, and therefore considered as an important approach for adjuvent therapy against MDR bacterial infections. Hence in the current study, ZapB protein of multidrug resistant Klebsiella pneumoniae was cloned, and expressed in E. coli system. To understand its role, and to assess the mechanism of ZapB activation, the characteristic …

Redox Reprogramming In Neurogenesis: Candidate Developmental Switches And Targets Of Oxidative Toxicity In The Redox Proteome, Ryan Jacob Summerhays

Theses and Dissertations

Neurogenic differentiation requires coordinated redox regulation, yet how reversible cysteine oxidation is remodeled at proteome scale during this process remains poorly defined. Here, we asked whether differentiation is associated with selective, site-specific changes in reversible cysteine oxidation and whether oxidative stress reveals developmentally conditioned vulnerabilities within this redox landscape. To address this, we applied a discovery-oriented, proteome-scale redox profiling strategy that quantifies condition-dependent changes in reversible cysteine oxidation using CysPAT labeling, phosphopeptide enrichment, and multiplexed TMT mass spectrometry. Neurogenic differentiation was characterized by reproducible, bidirectional, and highly site-specific remodeling of reversible cysteine oxidation at discrete regulatory nodes, as well as …

Emergence, Differentiation, And Modeling Of Hematopoietic Stem Cells In Developing Embryos, Lucy Shive

Caroliniana Undergraduate Research Journal

In the field of developmental biology, the understanding of embryogenesis is driven by ever-advancing techniques of studying embryos’ structures and behaviors. Yolk sacs are critical to an embryo’s survival and its function in producing a mature organism from a simple zygote. A hallmark of embryonic yolk sacs is their production of primitive hematopoietic stem cells (HSCs). Recent research has explored the mechanisms by which these HSCs develop and migrate, as well as the mechanisms by which they differentiate into various cell types. This more thorough understanding of HSCs is the basis for the development of embryo models, peri-gastruloids, from stem …

Singing Not To Sing: The Interplay Of The Environment And Behavior On The Reproductive Success Of Forest Breeding Migratory Birds, Miranda Bliss Zammarelli

Dartmouth College Ph.D Dissertations

Habitat selection is a key behavior that has consequences for fitness, which can shift with environmental variation. The environment can affect reproductive success indirectly by shaping behavior or via direct impacts. Many forest breeding migratory birds choose a habitat by establishing territories. To understand the interplay of environment and behavior on the reproductive success of forest breeding migratory birds, I leveraged long-term data and newly collected species-specific data from Hubbard Brook Experimental Forest, New Hampshire, USA. I analyzed over 50 years of territory maps from seven species occupying a 10-ha plot to understand how birds distribute themselves in a habitat. …

Assessing Walleye Recruitment Via Otc Marks And Temporal Sampling Changes In Smallmouth Bass Population Structure In Lake Mcconaughy, Nebraska, Robert D. Allison Iv

Biology Theses, Dissertations, and Student Creative Activity

Lake McConaughy is a socially and economically important reservoir managed to provide diverse, high-quality angling opportunities. Walleye are the most frequently targeted species, although Smallmouth Bass have increased in popularity in recent years due to improvements in abundance and size structure. Walleye have been stocked annually since 1989 to support the population and have been the focus of extensive research. In contrast, Smallmouth Bass have been present for over 80 years and are self-sustaining; however, their population has not been formally evaluated since introduction.

The first objective of this study was to develop an oxytetracycline (OTC) mark retention correction factor …

A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink

Faculty, Staff and Student Publications

While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel–liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both …