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Articles 1291 - 1320 of 104930
Full-Text Articles in Entire DC Network
Effect Of Herbage Mass And Allowance Upon Herbage Intake By Grazing Dairy Cows, J.A C. Meijs
Effect Of Herbage Mass And Allowance Upon Herbage Intake By Grazing Dairy Cows, J.A C. Meijs
IGC Proceedings (1977-2023)
An adequate supply of nutrients for grazing animals depends on the intake and nutritive value of herbage. Little information is available on factors affecting herbage intake of grazing cows, particularly for grazing systems that do not involve daily change of animals to a new pasture. Our objectives were to determine the effects of variation in herbage mass ( due to variation in stage of maturity) and of herbage allowance on herbage intake by grazing dairy cows and on efficiency of consumption (herbage consumed as a proportion of herbage accumulated). From 1976 to 1979 the herbage intake oflactating cows was determined …
Relation Of Animal Production To Stocking Rate On Cultivated Pastures In Cerrados Areas Of Brazil, C J. Escuder
Relation Of Animal Production To Stocking Rate On Cultivated Pastures In Cerrados Areas Of Brazil, C J. Escuder
IGC Proceedings (1977-2023)
The relationships among stocking rate, gain/animal, and gain/ha were compared on six grazed pastures. The experiment was established on an oxisol acrustox in Brazil. The pasture consisted of (1) jaraguagrass (J); (2) jaraguagrass plus legumes (J + L); (3) molassesgrass (M); (4) molassesgrass plus legumes (M + L); (5) pangolagrass (P); (6) Pangolagrass plus legumes (P + L); (7) mixture of grasses (jaragua, molasses, and pangola) plus legumes (JMP + L). Pasture of pangolagrass alone was discarded because of poor establishment. Four stocking rates were applied on each pasture, from 1.0 to 3.4 animals/ha. For all pastures, gains/animal decreased linearly …
Evaluation Of Forages Ensiled In Concrete Stave And Oxygen-Limiting Silos, J O'Leary, R W. Hemken, L S. Bull
Evaluation Of Forages Ensiled In Concrete Stave And Oxygen-Limiting Silos, J O'Leary, R W. Hemken, L S. Bull
IGC Proceedings (1977-2023)
This study evaluated corn silages stored in concrete stave and oxygen-limiting silos during 1978-1980. Factors considered included the effect of environmental conditions in each silo on silage stability and feeding value. Milk production was evaluated using Holstein cows, intake studies used Holstein heifers or steers. Weekly measurements of intake, milk production, silage temperature, pH, and yeast and mold content were made for each silage. Aerobic stability was determined monthly. Silo type had no effect on intake or milk production. Silage temperatures from the oxygen-limiting silo were higher, and the silage was less stable than that from concrete stave silos. No …
Round Baling From Field Practices Through Storage And Feeding, W L. Kjelgaard, P M. Anderson, L D. Hoffman, L L. Wilson, H W. Harpster
Round Baling From Field Practices Through Storage And Feeding, W L. Kjelgaard, P M. Anderson, L D. Hoffman, L L. Wilson, H W. Harpster
IGC Proceedings (1977-2023)
A model analysis compared labor and fuel requirements for round and rectangular bale systems. Round baling reduced harvesting, transport, and handling labor by one-half but increased fuel use by a factor of 1.6. When data from field studies of all dry matter (DM) losses were included, round baling required 80 % as much labor and 200 % as much fuel as did rectangular baling. Baling losses for round balers and stackers averaged 10 % compared with 3 % for rectangular balers. ·Dry-matter losses from mowing through feeding of field-cured round bales, including 6 months of outdoor storage, totaled 41 % …
Harvesting And Processing Effects On Alfalfa Protein Utilization By Ruminants, R Britton, D Rock, T Klopfenstein, J Ward, J Merrill
Harvesting And Processing Effects On Alfalfa Protein Utilization By Ruminants, R Britton, D Rock, T Klopfenstein, J Ward, J Merrill
IGC Proceedings (1977-2023)
Alfalfa (Medicago sativa) is an efficient and important means of producing supplemental protein for ruminants. This research was undertaken to characterize the value of alfalfa protein for ruminants and to show how the protein is affected by different harvesting or processing regimens. The effects of maturity (prebloom, one-tenth, one half, and full bloom) and processing method (freeze dried [FD], sun cured [SC], and oven heated [HJ), on percentage of nitrogen (N), acid detergent insoluble N (ADIN), in-vitro rumen ammonia release (NH3), and in-situ rumen protein degradation, using dacron bags (BAG), were studied on irrigated alfalfa harvested over 2 years. …
Comparison Of Conservation Methods Under Controlled Practical Conditions, H Honig, K Rohr, E Zimmer
Comparison Of Conservation Methods Under Controlled Practical Conditions, H Honig, K Rohr, E Zimmer
IGC Proceedings (1977-2023)
The most common forage conservation methods (direct-cut and low-moisture silage, barn,dried hay, and dehydration) have been compared under practical, but strictly controlled, conditions to determine their relative value for meeting the increasing demands of high-yielding ruminants. A grass mixture was used as forage, at different stages of maturity in different experiments. Parameters determined were changes of nutrient content; losses of DM and net energy; and, in three experiments, forage intake by dairy cows. From the results of the experiments, the following conclusions could be drawn: (1) roughage quality is influenced more by cuttng time than by preservation methods; (2) low-moisture …
Wet Fractionation Of Alfalfa: A Direct Forage-Harvesting System, M Collins, R G. Koegel, N A. Jorgensen, H W. Ream
Wet Fractionation Of Alfalfa: A Direct Forage-Harvesting System, M Collins, R G. Koegel, N A. Jorgensen, H W. Ream
IGC Proceedings (1977-2023)
In this systm, termed wet fractionation, fresh forage is macerated and pressed to remove approximately 50 % of the moisture. The result is a forage product containing 32 %-38 % dry matter (DM) that can be ensiled directly. In addition, the protein contained in the plant juice can be coagulated and removed. The remaining deproteinized juice contains large quantities of mineral nutrients that can be returned to the soil. This process has several potential advantages: (1) less weather-dependent harvesting, which minimizes harvest losses; (2) reduced harvesting time; (3) reduced fertilizer requirements; and (4) ability to harvest protein from land unsuited …
Hastening Hay Drying, J W. Thomas, T R. Johnson, M A. Wieghart, C M. Hansen, M B. Tesar, Z Helsel
Hastening Hay Drying, J W. Thomas, T R. Johnson, M A. Wieghart, C M. Hansen, M B. Tesar, Z Helsel
IGC Proceedings (1977-2023)
The objectives of these studies were to increase the drying rate of cut alfalfa (Medicago sativa) by treating with chemical solutions and to examine factors that influence drying. Time to dry and drying rate of cut alfalfa were studied under laboratory and field conditions. Treatment consisted of spraying the cut alfalfa with methyl esters of long-chain fatty acids, an emulsifier alone, or a combination of an emulsifier and a potassium carbonate solution. Alfalfa sprayed with solutions of each chemical under specified conditions increased drying rate and decreased drying time to 60% or 75 % dry matter (DM) or …
Alternative Treatment Systems To Increase The Drying Rates Of Green Forage Crops, W E. Klinner, O D. Hale
Alternative Treatment Systems To Increase The Drying Rates Of Green Forage Crops, W E. Klinner, O D. Hale
IGC Proceedings (1977-2023)
Forms of conditioning treatment are being developed that aim to minimize the barrier effect of the crop cuticle without sacrificing too much of the structural strength of the herbage. Effective surface abrasion and favorable windrow structure can be achieved with steel-spoked rotors, which are now beginning to be offered commercially. More recently, plastic brushes have been developed because the higher population density and yielding ability of the crop-engaging elements, plus the absence of metal components, appeared to offer additional advantages. Four different brush conditioner systems have been evaluated in the laboratory and in replicated field experiments. Tufted brushes using trilobar …
Effects Of Microwave Treatment On Drying And Respiration In Cut Alfalfa, S A. Seif, D A. Holt, V L. Lechtenberg, R J. Vetter
Effects Of Microwave Treatment On Drying And Respiration In Cut Alfalfa, S A. Seif, D A. Holt, V L. Lechtenberg, R J. Vetter
IGC Proceedings (1977-2023)
After forage crops are cut mechanically, they usually undergo some degree of natural drying before being stored or further processed. During early stages of drying, plant respiration continues. Treatments or management practices that hasten drying and reduce postharvest respiration are desirable, because they minimize quantity and quality losses. Our objective was to determine the effects of brief microwave treatment on subsequent natural drying rate and respiration of alfalfa (Medicago sativa L. ). Duplicate samples of field grown Apollo alfalfa were subjected to focused microwave energy (2,450 MHz) generated at 0.25, 0.50, or 1.0 kilowatt of power for 3, 6, …
Effect Of Formic Acid- Formaldehyde Treatments On The Nitrogenous Constituents In Annual Ryegrass Silage, M L. Fishman, F Mchan, D Burdick
Effect Of Formic Acid- Formaldehyde Treatments On The Nitrogenous Constituents In Annual Ryegrass Silage, M L. Fishman, F Mchan, D Burdick
IGC Proceedings (1977-2023)
Prevention of proteolysis during ensiling is important in preserving the nutritive value of silage. Hence, the mechanism by which silage protein is protected against degradation was studied in wilted annual ryegrass (Lolium multiflorium Lam.) silage pretreated with formic acid, formaldehyde, and a formic acid-formaldehyde mixture. Raw-wilted ryegrass, control ryegrass silage, and treated ryegrass silage were extracted and fractionated under conditions previously found to maximize yield of nitrogenous constituents and minimize proteolysis during the extraction of fresh grass. Extractions were by boric acid-borate buffer at pH 8.0 with and without detergent (1 % sodium dodecyl sulfate). Sodium metabisulfite, an antioxidant, was …
Addition Of Lactobacillus Sp. To Aid The Fermentation Of Alfalfa, Corn, Sorghum, And Wheat Forages, N J. Moon, L O. Ely
Addition Of Lactobacillus Sp. To Aid The Fermentation Of Alfalfa, Corn, Sorghum, And Wheat Forages, N J. Moon, L O. Ely
IGC Proceedings (1977-2023)
As preservation of forage by ensiling has increased, so has the use of additives to enhance acid fermentation. Many of the fermentation aids currently on the market contain microflora to insure a lactic acid fermentation. The objectives of this study were to characterize the basic patterns of fermentation in a variety of crops and to evaluate the effects of adding selected microflora to forages to enhance the fermentation. Four crops were ensiled in each of three seasons. Alfalfa was harvested at 20 %-40 % bloom, second cut; wheat was cut in the early dough stage; corn was cut in the …
Interrelationships Between Pattern Of Fermentation During Ensilage And Initial Crop Composition, J M. Wilkinson, P F. Chapman, R J. Wilkins, R F. Wilson
Interrelationships Between Pattern Of Fermentation During Ensilage And Initial Crop Composition, J M. Wilkinson, P F. Chapman, R J. Wilkins, R F. Wilson
IGC Proceedings (1977-2023)
Relationships between crop composition and silage composition were examined for 231 silages made at the Grassland Research Institute from 1968 to 1978 without additives. A test was made of the model of Weissbach et al. (1974) in which silage characteristics were related to the percentage of dry matter in the crop (OM) and the ratio of sugar (Z) to buffering capacity (PK). Although these factors accounted for significant variance, the percentage accounted for was low at 36 % for lactic acid (percentage of total acids), 26 % for Flieg's score, 22 % for ammonia N (percentage of total N), and …
Effect Of Delayed Sealing During Ensiling On Fermentation And Dry-Matter Loss, N Takano, Y Masaoka, T Manda
Effect Of Delayed Sealing During Ensiling On Fermentation And Dry-Matter Loss, N Takano, Y Masaoka, T Manda
IGC Proceedings (1977-2023)
Two experiments were carried out from 1976 to 1980 to ascertain the effect of delayed sealing of silo on fermentation, dry· matter (DM) loss, digestibility, and silage intake. The effect of delayed sealing (up to 72 hours) of grass and corn silage was tested in laboratory silos on fermentation quality with storage temperatures at 15°C and 30°C, moisture content from 49% to 85 % , water-soluble carbohydrate (WSC) content ranging from 11.1 % to 17.5%, and with and without an addition of 0.25% formic acid. In all cases, delayed sealing resulted in poor-quality silage with high pH values and low …
Improving Hay Quality By Ammoniation, K J. Moore, V L. Lechtenberg, K S. Hendrix, J M. Hertel
Improving Hay Quality By Ammoniation, K J. Moore, V L. Lechtenberg, K S. Hendrix, J M. Hertel
IGC Proceedings (1977-2023)
Experiments were conducted to determine the effect of hay ammoniation on hay consumption and weight gain by steers when the hay was fed unsupplemented and supplemented with energy and protein. Mature orchardgrass (Dacrylis glomerata L.) hay was baled in early June 1979 and treated with anhydrous ammonia at 30 g/kg of hay. Seven weeks after treatment the hay was uncovered and allowed to aerate for 3 days. It was then fed to weanling steer calves weighing approximately 225 kg each. Similar hay baled from the same field but not ammoniated was fed to separate groups of steers. Both the treated …
Evaluations Of Low-Quality Roughages And Fibrous Cereal Grains Treated With Various Chemicals, G C. Fahey Jr, L L. Berger, M I. Mora, P J. Van Der Aar
Evaluations Of Low-Quality Roughages And Fibrous Cereal Grains Treated With Various Chemicals, G C. Fahey Jr, L L. Berger, M I. Mora, P J. Van Der Aar
IGC Proceedings (1977-2023)
Large improvements in the feeding value of low-quality roughages have resulted from treatment of them with various chemicals. Chemical treatment of grains may also be a potentially useful practice. The research reported here was designed (1) to determine how Chelating Metal Caustic Swelling (CMCS), a nontoxic, alkaline, aqueous reagent, compares with sodium hydroxide (NaOH) in enhancing in-vitro cellulose digestion (IVCD) of cornstalks (CS) (Zea mays) and soybean residues (SBR) (G!),cine max.), and (2) to evaluate the effects of NaOH and CMCS treatments of fibrous grains using in-situ techniques. CMCS or 7.5% NaOH solutions were added to CS or SBR at …
Effect Of Solvent Treatments On Intake And Digestibility Of Corn Stover, D M. Schaefer, M R. Ladisch, C H. Noller, V L. Lechtenberg
Effect Of Solvent Treatments On Intake And Digestibility Of Corn Stover, D M. Schaefer, M R. Ladisch, C H. Noller, V L. Lechtenberg
IGC Proceedings (1977-2023)
Treatment of crop residues with low levels of sodium hydroxide has been shown to improve organic-matter digestibility and animal performance. One objective of these experiments was to evaluate the effects of three treatments -water, sodium hydroxide, and chelating metal cellulose-swelling solution-on solubilization of cell-wall components in corn (Zea m£rys) stover. The two latter treatments were balanced for level of sodium hydroxide application, which was .3 .2 % of stover dry matter. The second objective was to determine the effects of these treatments on in-vitro and in-vivo digestibility as well as on consumption of corn stover. Twelve growing ram lambs were …
Factors Causing Greater In-Vitro Than In-Vivo Digestibility Of Sodium Hydroxide - Treated Roughages, L L. Berger, T J. Klopfenstein, R A. Britton
Factors Causing Greater In-Vitro Than In-Vivo Digestibility Of Sodium Hydroxide - Treated Roughages, L L. Berger, T J. Klopfenstein, R A. Britton
IGC Proceedings (1977-2023)
Research on sodium hydroxide (NaOH) treatment oflow-quality roughages generally indicates that in-vivo digestion is lower than in-vitro digestion. The purpose of this research was to identify factors that may cause less of the potentially digestible fiber to be digested in vivo than in vitro. Corn (Zea mays) cobs were raised to 60% moisture and treated to contain 0%, 2.5%, 5.0%, 7.5 % , and 10.0% NaOH. Lambs were fed diets containing 80% cobs and 20% supplement, giving a complete mixed diet con· taining 0%, 2.0%, 4.0%, 6.0%, and 8.0% NaOH. Five abomasally cannulated lambs were assigned to a 5 x …
Relationship Between Silage Quality And 15 N-Nitrate Reduction During Ensilage, K Ataku, M Horiguchi, T Matsumoto
Relationship Between Silage Quality And 15 N-Nitrate Reduction During Ensilage, K Ataku, M Horiguchi, T Matsumoto
IGC Proceedings (1977-2023)
Nitrate in forage has been proven to occasionally poison ruminants. Our recent studies, however, have shown that a high concentration of nitrate inhibits butyric acid fermentation to the advantage of the silage quality. This work was undertaken to see the relationship between silage quality and the pattern of nitrate reduction during ensilage.
Oregon State Rank Assessment For Willamette Navarretia (Navarretia Willamettensis), Nora Dunkirk
Oregon State Rank Assessment For Willamette Navarretia (Navarretia Willamettensis), Nora Dunkirk
Institute for Natural Resources Publications
Oregon state conservation status assessment for Willamette Navarretia (Navarretia willamettensis) using NatureServe methodology, 2026.
Lesson 3. Sky Explorers: The Rhythm Of The Moon And My Garden, Rachel Pastrana, Madhav P. Nepal
Lesson 3. Sky Explorers: The Rhythm Of The Moon And My Garden, Rachel Pastrana, Madhav P. Nepal
iLEARN Teaching Resources
In this kindergarten lesson, students become "Sky Explorers" as they investigate the patterns and rhythms of the Sun, Moon, and Earth. Through storytelling, movement activities, Oreo Moon modeling, outdoor observations, and hands-on exploration, students learn how Earth's rotation creates day and night and how the Moon changes appearance through predictable phases. Students explore the Lakota concepts of Wí (Sun), Haŋwí (Moon), and Mitákuye Oyás'iŋ (We Are All Related) while making connections between natural cycles, food systems, and plant growth. Students discover how people have long observed the Moon as a natural calendar and how farmers and gardeners use seasonal patterns …
Examining The Relationship Between Civic Agriculture Participation And Civic Engagement In South Texas, Allison Kaika, Dongkyu Kim, William Donner, Alexis Racelis, Owen Temby
Examining The Relationship Between Civic Agriculture Participation And Civic Engagement In South Texas, Allison Kaika, Dongkyu Kim, William Donner, Alexis Racelis, Owen Temby
School of Earth, Environmental, & Marine Sciences Faculty Publications
Civic agriculture is often credited with strengthening democratic life by encouraging civic and political engagement, yet this claim has scarcely been tested in socioeconomically marginalized regions. Using original survey data collected through a combination of random and purposive sampling, this study assesses that relationship in the Lower Rio Grande Valley of Texas, a majority-Hispanic agricultural region marked by high poverty and low civic participation. Phone and online surveys were administered in English and Spanish to reach both the general population and individuals involved in civic agriculture initiatives, yielding over 400 responses. We examine whether civic agriculture participation predicts greater community …
Lesson 2. The Soil Doctors: Healthy Vs. Thirsty Soil Detectives, Rachel Pastrana, Madhav P. Nepal
Lesson 2. The Soil Doctors: Healthy Vs. Thirsty Soil Detectives, Rachel Pastrana, Madhav P. Nepal
iLEARN Teaching Resources
In this lesson, Kindergarten students in Norris, South Dakota, become "Soil Detectives" to investigate the health of Maka (the Earth). By using their hands to touch, squeeze, and compare local schoolyard soil, students learn to identify Maka Wasté (Healthy Soil) and Maka Puza (Thirsty Soil). This lesson utilizes communal storytelling and Lakota terminology to ground scientific inquiry in local Indigenous knowledge and South Dakota land history. Students apply Regenerative Agriculture principles by providing a "cure" protecting the soil with a natural blanket—and conclude with a Wóglaka (Reflection Circle) to share their experiences as young stewards of the land.
Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave
Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave
Research outputs 2022 to 2026
Membrane-associated fungal proteins mediate essential functions and contain bioactive proteins with therapeutic potential but are underrepresented in aqueous extracts due to hydrophobicity and lipid associations. Ultrasound-assisted aqueous extraction was applied to Lion’s mane (Hericium erinaceus), and the proteins were fractionated by molecular weight (≥30 kDa, 10–30 kDa, 3–10 kDa). Proteomic profiling using data-dependent (DDA) and data-independent (DIA) mass spectrometry identified 1500 and 1702 proteins, respectively (1% global FDR). Ultrasonication induced surface irregularity and a less compact, heterogeneous microstructure. Topology predictions showed higher proportions of transmembrane and secretory proteins in ultrasonicated fractions. Extraction preserved protein integrity (82% molecular-weight retention, 97% tryptic …
Agrivoltaic Shading Reduces Soil Greenhouse Gas Fluxes In A Semi-Arid Vineyard, Marcelo Gomes Da Silva, Rafael M. Almeida, Carine Cocco, Engil Pereira
Agrivoltaic Shading Reduces Soil Greenhouse Gas Fluxes In A Semi-Arid Vineyard, Marcelo Gomes Da Silva, Rafael M. Almeida, Carine Cocco, Engil Pereira
School of Earth, Environmental, & Marine Sciences Faculty Publications
Agrivoltaic systems are expanding in semi-arid regions, raising questions about how panel driven shading alters soil greenhouse gas exchange. We used automated chambers to measure high frequency soil CO2, N2O, and CH4 fluxes in a newly established vineyard agrivoltaic system in Texas across three shading intensities (0%, 35%, 88%) that represent the light environment beneath panels as shaped by panel tilt and solar trajectory. Shading primarily cooled the soil, reducing mean soil temperature from 35.9 °C (0%) to 32.5 °C (35%) and 30.5 °C (88%), while mean soil water content shifted modestly (0.125, 0.106, and 0.130 m3 m−3, respectively). Over …
Impact Of Dolutegravir-Based Regimens On Patient Satisfaction And Quality Of Life Among People Living With Hiv: A Systematic Review And Meta-Analysis, Mustapha Muhammed Abubakar, Christabel Ogechukwu Okoye, Ruth Jeminiwa, Ifeanyi Kanayo Ifeorah, Lotanna Ezeja, Yusuf Dauran, Sahabi Musa, Silas Usen Joel, Abdurrahman Murtala Bello, Amauche Pearl Ngige, Gabriel Ezenri, Abdulmuminu Isah, Ifunanya Ikhile, Blessing Onyinye Ukoha-Kalu
Impact Of Dolutegravir-Based Regimens On Patient Satisfaction And Quality Of Life Among People Living With Hiv: A Systematic Review And Meta-Analysis, Mustapha Muhammed Abubakar, Christabel Ogechukwu Okoye, Ruth Jeminiwa, Ifeanyi Kanayo Ifeorah, Lotanna Ezeja, Yusuf Dauran, Sahabi Musa, Silas Usen Joel, Abdurrahman Murtala Bello, Amauche Pearl Ngige, Gabriel Ezenri, Abdulmuminu Isah, Ifunanya Ikhile, Blessing Onyinye Ukoha-Kalu
College of Pharmacy Faculty Papers
Background: Despite the global scale up of dolutegravir (DTG)-based regimens as the preferred first-line therapy for persons living with HIV (PLHIV), no comprehensive evidence exists on its effect on patient-reported outcomes such as Quality of Life (QoL) and patient satisfaction (PS). We conducted a systematic review and meta-analysis to provide the first comprehensive quantitative synthesis of the effect of DTG-based regimens on QoL and PS among PLHIV.
Method: We conducted literature search on PubMed, Scopus, Embase and Cochrane Library databases for peer-reviewed, primary studies published from January 2015 to January 2025. Studies using validated tools to evaluate QoL and PS …
Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do
Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do
Journal for Sports Neuroscience
Abstract
Background: Nicotinamide adenine dinucleotide (NAD⁺) is a central regulator of neuronal energy metabolism, mitochondrial function, and axonal integrity. Following mild traumatic brain injury (mTBI) and repetitive subconcussive exposure, neurons undergo a neurometabolic crisis characterized by impaired oxidative phosphorylation, increased ATP demand, and depletion of intracellular NAD⁺ pools. Pre clinical models demonstrate that NAD⁺ depletion contributes to central energy dysregulation, cognitive dysfunction, and axonal and neuronal degeneration through disruption of NAD⁺-dependent pathways including SIRT1-mediated mitochondrial resilience, PARP1-driven NAD⁺ consumption, and SARM1-associated axonal breakdown. Despite growing preclinical evidence supporting NAD⁺based neuroprotection, human clinical data remains absent.
Methods: A real-world clinical pilot …
Rape Pregnancies And Consequent Ptsd Resulting From The Overturn Of Roe V. Wade, Emma Lindenfelser, Yulia Garaeva, Nenette Nti-Agyemang, Ellen Davis, Anna Kabwa, Alexandra M Calaman
Rape Pregnancies And Consequent Ptsd Resulting From The Overturn Of Roe V. Wade, Emma Lindenfelser, Yulia Garaeva, Nenette Nti-Agyemang, Ellen Davis, Anna Kabwa, Alexandra M Calaman
Binghamton University Undergraduate Journal
Prior to the 1973 Roe v. Wade ruling, access to safe legal abortions was limited and often restricted along racial, economic, and geographic lines. Nearly fifty years later, women’s health policy evolved again following the 2022 Dobbs v. Jackson Women’s Health Organization decision overturning Roe v. Wade. This court ruling decimated federal protections of abortion. This paper presents the research that the 2022 Dobbs judicial decision may contribute to and exacerbate rape-related PTSD on 1 out of 20 American who are unable to access a safe abortion after a rape-related pregnancy. Pregnant women living in conservative states that have outlawed …
Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes
Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes
Department of Biochemistry and Molecular Biology Faculty Papers
Chromatin insulators, a.k.a. boundary elements, separate regions of the chromosome with distinct chromatin characteristics, including distinct histone modifications. This activity affects gene expression by allowing chromatin domains to be stably regulated and maintained. Insulators also block enhancer-promoter interactions and, somewhat paradoxically, facilitate other interactions, particularly when they stitch together distant regions of the chromosome by pairing with specific partners. Here we explore how long-range interactions facilitated by insulator pairing are affected by the presence of two potentially competing partners. Our results show that when two partners are present, they can reduce each other's effects on distant gene expression, suggesting that …
Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner
Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients (L248H and M376V MFN2 mutations) and wild-type mouse embryonic fibroblasts expressing these variants, we studied how MFN2 mutations impact mitochondrial dynamics beyond fusion. We analyzed mitochondrial morphology and dynamics by live-cell confocal microscopy and tested fusion/fission protein levels, oxygen consumption rate (OCR), extracellular …