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Effect Of Variety And Seaweed Extract Spray In The Content Of Some Medically Active Phenolic Compounds In Grape Fruits, Ali Ahmed Hussein Almyali, Salim Kadhim, Ali S. Hassoon, Ameer Al Fatlawy

Al-Bahir

Grape (Vitis vinifera L.) is one of the most economically significant fruit crops which has a large adaptive range, nutrition and medicine effect. A variety of 70 types of grapes are planted on more than 11.6 million plants in Iraq, generating a total annual output of more than 421,000 tons. Increasing grape quality, and particularly the phenolic composition recently has been of major interest. Leaf nutrition – particularly seaweed extracts, being rich in amino acids, trace elements and growth promoting substances – has proved to be a potential tool to enhance plant growth and fruit biochemical quality. The …

Research Process Toward The Creation Of Transgenic Beetles, Abraham B. Alton, Nathan Dauk, Jonah Jex, Brian D. Jensen, Sandra Hope

Library/Life Sciences Undergraduate Poster Competition 2026

Honorable Mention - Poster Design

Create a generalizable, reliable, and efficient procedure for insect genetic modification.

Insects born parasitic diseases such as malaria cause hundreds of millions of deaths each year. Many of these diseases could be eliminated if we had a reliable method for genetically modifying insects.

Curriculum For A Two Semester Calculus Course Specializing In Life Science And Data Science, Patrick Mcclain

LSU Master's Theses

Traditionally, introductory calculus has been designed for engineering and physics students, often leaving students majoring in data science or life sciences with a curriculum that lacks professional relevance and is overly reliant on problems that focus on computational fluency. This thesis proposes a two-semester sequence, called MATH 153X and MATH 154X, specifically tailored for the Louisiana State University (LSU) Dual Enrollment program and university-level data science and life sciences majors. By integrating modern computational tools—such as symbolic calculators and artificial intelligence (AI) tools—the proposed curriculum shifts the pedagogical focus from procedural symbolic manipulation toward conceptual literacy.

Through a series …

Genome Wide Association Study (Gwas) On Different Economic Traits And Epigenetic Stability Of Sweetpotato In Louisiana, Ajay Dhungana

LSU Doctoral Dissertations

Sweetpotato [Ipomoea batatas (L.) Lam] is a globally important food, feed, and industrial crop, yet its improvement is constrained by a complex hexaploid genome, clonal propagation, and susceptibility to multiple diseases. In Louisiana, production is threatened primarily by Fusarium oxysporum f. sp. batatas (Fusarium wilt) and Ceratocystis fimbriata (Black rot). Furthermore, the in vitro propagation methods essential for disease-free planting material and germplasm conservation can introduce epigenetic instability that undermines clonal fidelity. This dissertation integrates genome-wide association studies (GWAS), genotype by environment interaction (GEI) and DNA methylation profiling to dissect resistance mechanisms and assess epigenetic stability in Louisiana sweetpotato …

The Reform Of Prior Appropriation And The Fate Of Great Salt Lake, Christopher L. Lant, Rocky Seeley, Beth Parker, Andrew Follett

Spring Runoff Conference

Legal Issues Raised by the Decline of Great Salt Lake

• Violations of Clean Air Act from dust threaten federal intervention
• Petition to list Wilson’s Phalarope as an endangered species

Fisheries Occasional Publication No. 151 - Response To 2025 External Review Of Integrated Stock Assessments For Key Wa Demersal Indicator Stocks, Brett Crisafulli, Emily A. Fisher, Matias Braccini, Rubie Evans-Powell, Fabian I. Trinnie, Ainslie Denham, S. A. Hesp

Fisheries Occasional Publications

Consistent with national trends, the Department of Primary Industries and Regional Development (DPIRD) is transitioning to the globally recognised Stock Synthesis (SS) platform to support more robust, transparent, and internationally aligned assessments. To ensure this transition remains scientifically sound, DPIRD commissioned an independent expert review in 2025, following a previous review in 2024. The 2025 review was conducted by Professor André Punt and focused on integrated models for three key WA fish stocks: red emperor in the Kimberley, WA dhufish in the southern West Coast Bioregion, and sandbar shark at the statewide level. This publication summarises the findings and recommendations …

The Evolution Of Self-Awareness In Conscious Organisms, Robert A. Dielenberg

Journal of Conscious Evolution

Self-awareness in conscious organisms remains an enduring puzzle for philosophers and neuroscientists. This paper proposes a tripartite evolutionary model tracing its emergence through three sequential types: the sensory self (primitive egocentric, valence-tagged awareness of sensory states), the bodily self (external objectification of the body as a distinct entity, evidenced by mirror self-recognition in select species), and the cognitive self (internal objectification of the mind enabling recursive self-transformation). Adopting a monist framework, the model treats consciousness as the biological substrate of delayed neural apperception (the “Delayed Present”), within which selves emerge as increasingly sophisticated models. It distinguishes non-human metacognition—implicit, online regulation—from …

The Molecular Determinants Of Deglycation And Substrate Specificity In Fructosamine Kinases, Jenet Matlack

USF Tampa Graduate Theses and Dissertations

Protein glycation is a universal, non-enzymatic modification that occurs when a sugar covalently attaches to a primary amine. These spontaneous modifications may have deleterious or regulatory effects on protein function, and their removal is mediated by the conserved metabolic kinase fructosamine-3-kinase (FN3K). Despite its crucial role in protein repair, we currently have a poor understanding of how FN3K engages or phosphorylates its substrates. Additionally, the molecular basis for the distinct yet overlapping substrate specificities of FN3K and its paralog, ketosamine-3 kinase (KT3K), remains unresolved. By integrating structural biology, biochemistry, and ancestral protein reconstruction (APR), this thesis elucidates the catalytic mechanism …

Global Transcriptomic Insights Into Nla-Dependent Boron Toxicity Responses In Arabidopsis Thaliana, Doğa Seli̇n Kayihan

Turkish Journal of Botany

Boron (B) toxicity disrupts multiple metabolic and signaling processes in plants, yet its interaction with post-translational regulators remains poorly understood. The E3 ubiquitin ligase NITROGEN LIMITATION ADAPTATION (NLA) is known to control nutrient transporter turnover, but its role in B toxicity responses has not been previously characterized. Here, we present the first genome-wide transcriptomic analysis of nla mutant Arabidopsis thaliana exposed to mild (1 mM) and moderate (2 mM) B toxicity. Loss of NLA caused a profound reprogramming of gene expression, marked by constitutive activation of ribosome- and translation-related pathways and strong repression of MAPK signaling, α-linolenic acid metabolism, and …

Functional Trait Structure In A Plant Community In Central Anatolian Steppe, Cansu Ülgen, Zeynep Ladi̇n Coşgun, Bariş Özüdoğru, Çağatay Tavşanoğlu

Turkish Journal of Botany

Exploring the trait structure of grassland plant communities enhances our understanding of how these communities will respond to climate change and disturbances such as herbivory. The trait structure of a plant community was investigated in the Central Anatolian steppe, an ecoregion with high biodiversity that has been largely unexplored in terms of plant functional ecology. Fifty plant species in the community were measured across 9 plant traits, including several leaf traits (leaf area, leaf dry matter content, specific leaf area, leaf thickness, and leaf nitrogen content), two seed traits (seed mass and seed shape), as well as the plant height …

Impact Of In-Depth Adoption Of System Of Rice Intensification On Food Security Of Smallholder Farm Households In Mali, Moussa Macalou, John Baptist D. Jatoe

Professional Agricultural Workers Journal

The system of rice intensification (SRI) was implemented in Mali to boost rice productivity. The objectives of this paper are to identify the constraints faced by SRI adopters, estimate the food security index, and assess the impact of in-depth adoption of SRI on smallholder farm households’ food security. The study uses Kendall’s ranking to rank the six main constraints identified from the literature. The study uses the Household Food Insecurity Access Scale to estimate households’ food security index. Using primary data collected on rice farm households, the study combines the multivalued treatment effect inverse probability weighted regression adjustment and the …

Genome-Wide Crispr Screen Identifies A Cytokine-Enhancer Circuit Driving Hif-2Α Activation In Renal Cancer, Jun Fang, Jeremy M Simon, Tao Wang, Yunpeng Gao, Xianju Bi, Lianxin Hu, Chengheng Liao, Cheng Zhang, Yayoi Adachi, Jin Zhou, Hongyi Liu, Qian Liang, James A Nathan, Ram Mani, James Brugarolas, Qing Zhang

Faculty, Staff and Student Publications

Resistance to HIF-2α inhibitors such as Belzutifan underscores the need to better understand how HIF-2α is transcriptionally regulated in clear cell renal cell carcinoma (ccRCC). Here, we uncover a cytokine-driven enhancer mechanism that sustains HIF-2α expression through the JAK1-STAT3 signaling pathway. Using a genome-wide CRISPR screen in VHL-deficient ccRCC cells, we identified SOCS3 as a key negative regulator of HIF-2α. Mechanistically, loss of SOCS3 activates JAK1-STAT3 signaling, leading to the recruitment of STAT3 to distal enhancers upstream of EPAS1 that physically loop to its promoter to drive HIF-2α transcription. This cytokine-enhancer circuit was recapitulated in ccRCC patient samples and functionally …

Best Integrated Writing Spring 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Aquifer Characteristics And Groundwater Flow Modeling For Sustainable Water Resources Development And Planning Using Modflow Software In India, Ravi Sharma

AUIQ Complementary Biological System

MODFLOW is one of the most commonly used numerical models for simulating groundwater flow. Its structured data design and compatibility with GIS tools make it suitable for groundwater assessment and planning. Groundwater forms an important part of the hydrological cycle and occurs within the pore spaces of sedimentary rocks or within fractures in hard rock terrains. Although its distribution beneath the surface is not always uniform or predictable, it is still considered one of the cleanest, most accessible, and quickly available freshwater sources. Numerical groundwater models help convert complex subsurface processes into simplified relationships that describe flow behavior. Even though …

The Impact Of Michi-No-Eki (Roadside Stations) On The Regional Economy: An Input–Output Analysis Of Minamiboso City In Chiba Prefecture, Ryusaku Matsuo, Takeru Aizawa, Gon Jan, Wei Yuanxin, Masaharu Uchiyama, Gento Tagami

Japanese Society and Culture

This study quantitatively examines the economic impact of Michi-no-Eki (Roadside Stations) in Minamiboso City, Chiba Prefecture, using an input–output analysis based on the Chiba Prefectural Interindustry Table. Eight Michi-no-Eki were evaluated in terms of direct, indirect, and induced effects, including employment creation. The results show that the total production-inducing effect generated by the stations amounts to ¥7.02 billion per year, and the employment-inducing effect reaches 108.7 persons annually, indicating that Michi-no-Eki function as a central engine of the local economy. Moreover, thematic diversity among stations—such as loquat, flowers, and seafood—enhances multiplier effects through inter-sectoral linkages. These findings demonstrate that Michi-no-Eki …

Construction Of Emerging Contaminants Risk Governance System, Cheng Li, Mingcheng Wang, Chunlei Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Emerging contaminants pose considerable risks to the ecological environment, human health, and social safety. The establishment of an emerging contaminants risk governance system constitutes a crucial component of the national ecological security strategy and the ecological civilization framework in the new era. When examined through the lens of the holistic view of national security and guided by the ecological civilization philosophy of the new era, China’s current efforts in managing emerging contaminants reveal several shortcomings—including a fragmented and incomplete risk management system, as well as preliminary stages in chemical environmental management policies and related technologies. Therefore, grounded in national conditions …

Structural Dynamic Response Assessment Of Clt Wall Structure Systems In Wind-Only And Sequential Seismic–Wind Scenarios, Yunxiang Ma, Qingli Dai, Xiang Zhao

Michigan Tech Publications

Because of concentrated connection damage, the impact of sequential hazards on CLT shear wall systems is much more severe than that on traditional concrete and steel structures considering ductile component behaviors. The present paper evaluated the dynamic response of CLT wall structures in wind-only and sequential seismic–wind scenarios and compared the structural dynamic responses and damage levels of different CLT wall systems. The structural models were established separately based on an SOM benchmark structure, a SOFIE project three-story CLT shear wall structure, and a PT CLT wall platform structure from the NHERI Tall Wood project. The equivalent fluctuating wind load …

Structural Dynamic Response Assessment Of Clt Wall Structure Systems In Wind-Only And Sequential Seismic–Wind Scenarios, Yunxiang Ma, Qingli Dai, Alexander Zhao

Michigan Tech Publications

Because of concentrated connection damage, the impact of sequential hazards on CLT shear wall systems is much more severe than that on traditional concrete and steel structures considering ductile component behaviors. The present paper evaluated the dynamic response of CLT wall structures in wind-only and sequential seismic–wind scenarios and compared the structural dynamic responses and damage levels of different CLT wall systems. The structural models were established separately based on an SOM benchmark structure, a SOFIE project three-story CLT shear wall structure, and a PT CLT wall platform structure from the NHERI Tall Wood project. The equivalent fluctuating wind load …

Morphometric And Reproductive Divergence Of Deep-Water Shrimps Plesionika Martia (A. Milne-Edwards, 1883) And P. Heterocarpus (A. Costa, 1871) Along A Depth Gradient In The Eastern Aegean Sea, Murat Özbek, Cengi̇z Koçak, Zafer Tosunoğlu

Turkish Journal of Zoology

This study provides a comparative analysis of two deep-water pandalid shrimp  species, Plesionika martia and P. heterocarpus, based on monthly samples collected  over one year in the Eastern Aegean Sea. Specimens were obtained from species-specific depth zones (550 m for P. martia and 350 m for P. heterocarpus) to examine  morphometric traits, sexual dimorphism, and reproductive patterns. A total of 4419  individuals were analyzed. Females were significantly larger and more abundant than  males (K–S test, p < 0.05), indicating pronounced sexual dimorphism. Length–weight relationships revealed negative allometric growth in both species, confirmed  by t-tests (p < 0.05). Reproductive activity differed markedly: P. martia showed a short  and distinct spawning period peaking in late autumn, whereas P. heterocarpus  displayed a prolonged, bimodal cycle with peaks in spring and summer. The gonadosomatic index (GSI) and the proportion of ovigerous females varied  significantly by season and species. A strong positive correlation between carapace  length and gonad weight was found, with a more linear relationship in P. martia and  greater variability in P. heterocarpus. Size at first maturity (L₅₀) was estimated at 22.3  mm CL for P. heterocarpus but could not be reliably determined for P. martia  due to limited small size data, likely reflecting ontogenetic depth segregation. The  consistent bathymetric separation between these species—also reported in the  Western Mediterranean—suggests ecological niche differentiation. Species-specific  management measures, including depth-based fishing restrictions and temporal  closures during reproductive peaks, are recommended to support the sustainable  exploitation of deep sea shrimp stocks in the region.

Frequencies And Roles Of Plants In The Diet Of Three Mesocarnivores (Canis Lupaster, Genetta Genetta, And Herpestes Ichneumon): Implications For Forest Regeneration In A North African Hot Spot (Algeria), Messaoud Bensidhoum, Abdelkrim Limane, Larbi Khifer, Ania Ben Ammar, Lylia Amrouche

Turkish Journal of Zoology

The Djurdjura National Park (PND, Algeria) is part of one of the world’s 36 biodiversity hot spots, recognised by the United Nations as a national biosphere  reserve. It contains the Darna primary forest, a key habitat for several mesocarnivore  mammals, including the golden wolf (Canis lupaster), the common genet (Genetta  genetta) and the ichneumon mongoose (Herpestes ichneumon). Although their diets  are primarily based on animal prey, these carnivores exhibit both qualitative and  quantitative reliance on plants, a pattern that merits thorough documentation. We  analysed 30 scats per species per month over four years (1440 scats per species).  More than 35% …

Latest Sightings Of The Striped Hyena In North Africa: Major Threats And Conservation Actions, Abderrazak El Alami, Abderrazzak Fattah, Ilyas El Alami, Ziad El Alami

Turkish Journal of Zoology

The striped hyena (Hyaena hyaena) is widely distributed across the northern half of Africa, the Middle East, the Arabian Peninsula, and parts of Asia. However,  numerous studies indicate that this carnivore is in decline, and it is currently classified  as near threatened on the IUCN Red List of threatened species. In North  Africa, the Hyaena hyaena barbara subspecies has been extirpated from many  areas. This article summarizes data collected from observations of the striped hyena  in North Africa between 2004 and 2024. Among the 418 striped hyenas recorded in  North Africa between 2004 and 2024, 18.4% (n = 77) were …

Visdb 20: A Manually Curated Resource Of Viral Integration Sites And Their Regulatory Maps In Human Diseases, Citu Citu, Ajeet Singh, Xinyi Liu, Mounika Ashannagari, Rinki Ratnapriya, Zhongming Zhao

Faculty, Staff and Student Publications

The integration of viral sequence into the human genome plays critical role in the onset of various diseases, especially cancers. To facilitate systematic analysis of these events, we present VISDB 2.0, an expanded and updated database of human viral integration sites (VISs). The current release contains more than 270,000 manually curated VISs derived from 209 peer-reviewed publications, covering 11 viruses, including four retroviruses and seven DNA viruses. This represents a 3.5-fold increase in VIS entries compared with the previous version. Each VIS record includes standardized genomic coordinates and annotations describing local genomic context, CpG islands, repetitive elements, chromosomal fragile sites, …

Is The Long-Horned Grasshopper Ruspolia Differens (Orthoptera: Tettigoniidae) A Novel, Nutritious, Functional, And Safe Alternative Food Product? A Review, Margaret Kababu, Collins Mweresa, Dorothy Nakimbugwe, Geoffrey Ssepuuya, Karlmax Rutaro, Nicodemus Matojo, Faith Nyamu, Robert Mbeche, Sevgan Subramanian, Sunday Ekesi, Chrysantus Tanga

All Peer-Reviewed Publications

Ruspolia differens Serville (Orthoptera: Tettigoniidae) is among the most widely consumed edible insect in Eastern and Central Africa, where it contributes to both household nutrition and income generation. As a nutrient-dense food source, it offers a promising alternative to curb food insecurity and malnutrition. Despite this, the consumption and use of the grasshopper is limited to its seasonal availability when it is collected from the wild. Coupled with this, is limited evidence on its domestication despite research advances to optimize conditions for mass production. This review was conducted to highlight research advances and gaps on production, processing, nutritional profile, and …

Filifactor Alocis Disrupts Efferocytosis To Sustain Inflammation In Periodontitis, Ella Dye, Silvia Uriarte, Ruth Idowu

The Cardinal Edge

Background: Filifactor alocis is a Gram-positive, obligate anaerobe that has emerged as a diagnostic marker of periodontitis. Neutrophils and macrophages are key players in oral immune homeostasis. Neutrophils are short-lived cells and constitutively undergo apoptosis. This apoptotic program can be accelerated or delayed by bacterial interactions. Macrophages clear apoptotic neutrophils via “efferocytosis,” a crucial mechanism for resolving inflammation and preventing tissue damage. The efferocytic process downregulates the expression and release of proinflammatory cytokines such as interleukin (IL)-6 and IL-23 while promoting anti-inflammatory responses. Our previous findings demonstrated that F. alocis delays neutrophil apoptosis, with fewer apoptotic cells observed after 18 …

Crepe Myrtle Bark Scale (Acanthococcus Lagerstroemiae) And Sooty Mold (Capnodium Sp.) Decrease Bloom And Fruit Number In ‘Natchez’ Crepe Myrtle (Lagerstroemia Xfauriei ‘Natchez’), Derald A. Harp, Beatriz Ruiz, Kara Bailey, Pedro Castillo, Phoebe Alvarez

Faculty Publications

Crepe myrtle bark scale (CMBS) (Acanthococcus lagerstroemiae) is an important pest of crepe myrtle in Texas, and infestations are accompanied by excessive growth of sooty mold (SM) that will cover stems, and, in severe cases, leaves. These combine to create significant stress on the plant, and anecdotal evidence suggests a decrease in bloom number under heavy infestation. In an existing planting of 24 ‘Natchez’ crepe myrtle in four blocks, three trees were randomly chosen in each block and treated with either a dinotefuran (year 1) or imidicloprid (year 2) drench. The three remaining trees were untreated. In February of year …

Targeting Il-1 Signaling In Recessive Dystrophic Epidermolysis Bullosa: Improved Survival And Pathogenesis In Rdeb Mouse Model, Rahim Hirani

NYMC Student Theses and Dissertations

Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating inherited blistering disorder caused by biallelic mutations in COL7A1, resulting in deficiency of type VII collagen (C7) and loss of dermal–epidermal adhesion. Beyond mechanical fragility, RDEB is characterized by chronic inflammation, progressive fibrosis, impaired wound healing, severe pain, and an exceptionally high risk of aggressive cutaneous squamous cell carcinoma. Emerging transcriptomic and cytokine profiling studies have identified interleukin-1 alpha (IL-1α) as a dominant and temporally upstream inflammatory mediator in RDEB skin. The central hypothesis of this dissertation is that IL-1α signaling functions as a key initiator and amplifier of inflammation-driven pathology …

Simulated Hearing Loss In Healthy Young And Older Adults Results In Poor Reaction Time In Older Adults., Victoria Kowalewski, Nicoleta Bugnariu, Rita M. Patterson, Jessica Hartos

Pacific Journal of Health

Emerging evidence links hearing loss to increased fall risk in older adults, yet mechanisms remain unclear. This study examined the impact of simulated hearing loss on reactive balance control in healthy young and older adults. Participants performed dual-task scenario involving auditory sentence repetition and unexpected surface translations. Hearing loss was simulated using Adobe Audition, applying frequency-specific attenuation based on moderate sensorineural hearing loss levels from the literature.

Speech-in-noise performance significantly declined under simulated hearing loss for both age groups (p < .001), confirming effective simulation, but not significant differences were found between age groups. Maximum COP-COM displacement (the scalar distance between Center of Pressure and Center of Mass) increased with perturbation intensity (Level 1 vs. Level 2: p < .001), but no significant differences were found between hearing conditions or age groups (p > .05), suggesting compensatory step execution was preserved.

Reaction time analysis revealed a significant interaction between hearing condition and perturbation level …

The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al.

Faculty Publications

Open data and code are crucial to increasing transparency and reproducibility, and in building trust in scientific research. However, despite an increasing number of journals in ecology and evolutionary biology mandating for data and code to be archived alongside published articles, the amount and quality of archived data and code, and subsequent reproducibility of results, has remained worryingly low. As a result, a handful of journals have recruited dedicated data editors, whose role is to help authors increase the overall quality of archived data and code. There is, however, a general lack of consensus around what a data editor should …

Unraveling Metabolic Determinants Of Isoniazid Susceptibility In Mycobacterium Tuberculosis, Erin Rilu Wang

Arts & Sciences Graduate Student Theses and Dissertations

Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB) and is one of the leading causes of death worldwide by an infectious agent. Furthermore, the emergence and evolution of drug resistance has significantly hindered global health efforts to combat this deadly epidemic. Thus, there is a critical need for development of new antibiotics with unique mechanisms of action and design of novel strategies for optimizing the efficacy of existing therapeutic regimens. It is estimated that 10.7% of new infected and 27.2% of previously treated TB cases are resistant to the frontline antibiotic isoniazid (INH), a central component of TB chemotherapeutic regimens. …

Breaking Into Hiv-1'S Epigenetic Vault: Cure Strategies To Eliminate The Viral Reservoir, Joanna Jones, Chelsea Gunderson, Brian Wigdahl, Michael Nonnemacher

Kimmel Cancer Center Faculty Papers

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that integrates into the host cell's DNA as a provirus. Transcription from the provirus is regulated in large part by cellular proteins and epigenetic factors. These may be repressive or permissive to productive infection. The host factors that regulate this balance are therefore attractive targets for HIV-1 therapeutics. Indeed, proviral chromatin is the focus of two of the current HIV-1 cure strategies. "Shock and Kill" uses latency reversal agents to open the provirus's chromatin, promoting high levels of gene expression that induce the killing of infected cells. "Block and Lock" uses …