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Capacity-Building Project To Progress The Implementation Of International Instruments To Combat Iuu Fishing (Capfish) : Summer Academy: West Africa, World Maritime University, Korea Maritime Institute, Ministry Of Oceans And Fisheries

Reports

The CAPFISH Project was created in response to an identified need for capacity-building to address illegal, unreported and unregulated (IUU) fishing and related matters - a complex problem affecting aquatic ecosystems, coastal communities, fishers and fish workers, and economic and national security. Over the last five years, the CAPFISH Project has provided training and educational materials on IUU fishing to developing country administrations around the world, most recently with a two-week regional Summer Academy for West Africa. This Academy ran for two weeks and included delegates from fisheries, maritime and enforcement agencies, industry, maritime training institutions, regional fisheries bodies, and …

Elli’S Liquid Flow In A Wavy Channel With Slip Effect, Wall Properties, And Heat Transfer, P. Devaki, Yatin Sood

Mansoura Engineering Journal

The dual behavior of Elli’s fluid motivated us to work on it. The fluid behaves as both Newtonian/ non-Newtonian based on the low and high shear rates, respectively. The paper focused on the flow of Ellis fluid in a peristaltic channel with wall properties and heat transfer. The channel is symmetric in nature, and slip conditions are considered near the elastic walls. The governing equations of the flow are solved analytically using suitable boundary conditions, which yield velocity and temperature functions. The novelty of the paper is to analyze the nature of Newtonian/non-Newtonian fluids under the same conditions so that …

Neuroimaging Correlates Of Differences In Learning From Repeated Probabilistic Outcomes, Allison E. Rudolph

CMC Senior Theses

Learning from experience requires integrating feedback over time, yet individuals vary widely in how effectively they extract structure from probabilistic environments. This study examined how such variability relates to neural responses in the ventral striatum (vStr), caudate nucleus, hippocampus, and medial prefrontal cortex (mPFC). Seventy-four participants across childhood, adolescence, and adulthood completed a modified Iowa Gambling Task during fMRI scanning, choosing whether to play or pass on four machines differing in expected value and variance. Behavioral learning slopes, calculated across six runs for each machine, were used to classify participants as learners or non-learners. Learners showed clearer improvement over time …

Consumer Perceptions Of Farmers Market Performance: A Comparative Analysis Across States And Age Groups, Azita Varziri, Timothy A. Woods, Shuoli Zhao

Agricultural Economics Faculty Publications

The USDA Agricultural Marketing Service has invested in direct-to-consumer initiatives to expand local food consumption and enhance farmers market opportunities. To evaluate the effectiveness of these efforts, this study employs a sample-selected ordered probit model to analyze consumer perceptions of farmers market performance across four states in the Southeast United States. Specifically, we examine differences in awareness and performance of product quality, diversity, and market infrastructure. Awareness and perceptions vary significantly by age, other demographics, and state. These insights provide market organizers and policymakers with data-driven strategies to tailor marketing efforts and improve engagement across diverse consumer segments.

Investigation Of Factors Influencing Electric Vehicle Adoption In Indonesia: Ev Owners’ Perspectives, Desrina Yusi Irawatia, Nur Aini Masruroh, Nur Mayke Eka Normasari

ASEAN Journal on Science and Technology for Development

Electric vehicle (EV) uptake in Indonesia remains markedly below policy benchmarks. This study applies the Unified Theory of Acceptance and Use of Technology version 3 (UTAUT3), an extension of UTAUT2 that incorporates personal innovativeness as an additional construct to examine its impact on both behavioral intention and actual EV adoption within the Indonesian context. Unlike studies that typically survey the general public, this study focuses on actual EV users and owners, providing more representative and responsive insights into real-world EV usage. A total of 208 respondents participated, with 135 from the Jabodetabek area and 73 from Surabaya. The UTAUT3 framework …

Anticancer Efficacy Of Methyl-Cantharidimide (Mca) In Liver Cancer, Yidong Li

Theses and Dissertations

Cancer is still one of the major public health challenges worldwide to the present day. Multi-drug resistance (MDR) that occurs in cancer chemotherapies is a non-negligible cause of cancer treatment failure and tumor recurrence. Overexpression of ATP-binding cassette (ABC) transporters is one of the most frequent mechanisms of MDR occurrence. Therefore, the establishment of a chemotherapy agent whose anticancer efficacy would not be affected by the overexpression of ABC transporters is in demand. Methyl-cantharidimide (MCA), a cantharidin (CTD) analog, has been approved in China for clinical liver cancer treatment. This study revealed that MCA was efficacious in the ABCB1-, ABCG2-mediated …

Practical Considerations For Conducting Canine Behavioral Science, Lucrezia Lonardo, Madeline H. Pelgrim, Jeffrey R. Stevens

Jeffrey Stevens Publications

Research on behavior in domestic dogs (Canis familiaris) has increased rapidly recently due to the interest in them as pets, working dogs, and model species for understanding evolution, domestication, and even human health. This interest in canine behavioral science has resulted in the creation of dozens of dog lab worldwide, with more starting every year. Our aim here is to review practical issues that potential dog researchers might consider when deciding how to set up a dog lab and conduct research in canine behavioral science. We hope that this can offer a path forward in promoting high-quality, cutting-edge …

A Comprehensive Statistical And Regional Analysis Of Lng-Powered Marine Vessels On Ghg Mitigation Strategies Considering Existing Bunkering Stations And Gwp Values, Canberk Hazar, Onur Yuksel, Murat Bayraktar

Journal of Marine Science and Technology–Taiwan

This study aims to quantify and analyse emissions from marine vessels that can operate on liquefied natural gas (LNG) but continue to use conventional fuels, largely due to the limited availability of LNG bunkering stations (BSs) over long distances. Four regions have been identified as having high concentrations of LNG-fueled vessels but limited access to operational BSs: the West Coast of the United States of America (USA), South Africa–Good Hope–Madagascar, Northwest Africa, and Brazil. This selection is based on the geographical distribution of these ships and the existing infrastructure. Hourly greenhouse gas (GHG) emissions have been calculated by considering the …

Proteome-Based Identification And Validation Of Nxpe3 In Childhood Acute Lymphoblastic Leukaemia, Najia Tabassum, Yamna Khurshid, Basir Syed, Aftab Ahmad, Sadia Muhammad, Rehan Imad, Talat Mirza

Pharmacy Faculty Articles and Research

Background: Childhood acute lymphoblastic leukaemia (cALL) tends to metastasize to central nervous system. Treatment with antileukemic agents against CNS leukaemia is an essential component for cure in ALL. Hence, it is essential to identify biomarkers for CNS infiltration. Proteomics, supported by mass spectrometry, is the platform for exploring biomarkers in various biological samples, contributing to translational research. Objectives: This study aimed to identify the plasma proteome profile of children across different risk groups of cALL. Neurexophilin and PC-esterase family, member 3 (NXPE3), was validated. The protein-protein interactions (PPI) of NXPE3 were evaluated with bioinformatics analyses. Methods: Plasma …

Temporal Avoidance By Gray Foxes Reflects Growing Pressure From Expanding Coyotes In The Neotropics, Madison Odenbach

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Coyotes (Canis latrans) are rapidly expanding their range towards South America, potentially threatening the world’s highest canid diversity residing on that continent. A better understanding of their interactions with native species is needed to anticipate potential competitive impacts. In Costa Rica, native gray foxes (Urocyon cinereoargenteus) likely occupy a similar niche to the coyote newcomer, yet little data exists on their interactions in tropical ecosystems. We hypothesized the two species separate temporally to minimize the potential for competition in our study area, given preliminary data suggesting high spatial overlap (57.1% of coyote-detected sites overlap with fox-detected …

Cogram: A Computational Pipeline For Genome Assembly And Reconstruction Using Graph Neural Networks, William Coggins

College of Graduate Studies: Theses & Dissertations

Genome assembly — the reconstruction of a complete DNA sequence from short, overlapping reads — remains a fundamental challenge in computational biology. A central difficulty is distinguishing true genomic overlaps from spurious connections arising from repetitive sequences, a task that traditional assemblers address through hand-tuned heuristic rules applied to de Bruijn or overlap graphs. This thesis introduces COGRAM (Coggins–Ramasamy Assembly Method), a genome assembly pipeline that reframes sequence reconstruction as an edge classification task on a k-mer overlap graph, replacing heuristic graph cleaning with a learned model.

COGRAM constructs a directed overlap graph from raw sequencing reads using a k-mer …

A Metabolite-Dependent Mechanism By Which Bifidobacterium Animalis Subsp. Lactis Promotes Bacteroides Colonization, Khashayar Shahin, Liang Wang, Zihan He, Bomin Lv, Arya Van Alin, Richard Lo-Man, Hao Wu, Philippe Sansonetti, Jean Marc Collard

Research outputs 2022 to 2026

Prokaryote-prokaryote symbiotic relationships influence interactions within microbial communities, affecting colonization, survival, and organization. Unlike competition, consortium species facilitate growth via metabolite cross-feeding. This study explored interactions between two early human gut colonizers: partially aerotolerant Bifidobacterium spp. and strict anaerobic Bacteroides spp., using omics techniques. Promotion of Bacteroides spp. growth by Bifidobacterium animalis subsp. lactis was demonstrated through co-culture experiments in anaerobic conditions. Metabolomic analysis revealed over 150 unique metabolites present in B. animalis subsp. lactis supernatants are absent in other Bifidobacterium species, including 3-hydroxycapric acid, D-alanyl-D-alanine, 2-isopropylmalic acid, and D-glucose 2-phosphate. These compounds served as nutritional substrates, including carbon and …

Baseline Lymphopenia Predicts Survival In Ici-Naïve Solid Tumor Patients Receiving Immune Checkpoint Inhibitors: A Propensity-Matched Real-World Pan-Cancer Analysis, Ahmed Ismail, Nina Balanchivadze, George R. Simon, Yanis Boumber

Department of Medicine Faculty Publications

Background: Baseline lymphopenia is common among advanced solid tumors and may influence the efficacy/safety of immune checkpoint inhibitors (ICIs), but large real-world evidence is limited. We evaluated the association between baseline absolute lymphocyte count (ALC) and clinical outcomes in adults with solid tumors treated with ICIs in routine practice. Methods: We performed a retrospective cohort study using TriNetX. Adults with solid tumors who received pembrolizumab, nivolumab, or atezolizumab (ICI-Naïve) between January 2015 and June 2026 were included. Baseline ALC was measured within 30 days before first treatment and was classified as lymphopenic (ALC < 1.5 × 10⁹/L) or non-lymphopenic (ALC ≥ 1.5 × 10⁹/L). Propensity score matching (1:1) yielded 5249 patients per group. The index date was the first immunotherapy date, and outcomes were assessed at 6, 12, 24, 36 months, and 5 years. The primary outcome was 24-month overall survival (OS); secondary outcomes were OS at 6 and 12 months and 6-month risks of healthcare utilization, immune-related adverse events (irAEs), and serious infections; and exploratory outcomes included OS at 36 months and 5 years. All outcomes were analyzed using Kaplan–Meier analysis, Cox proportional hazards models, and risk ratios. Subgroup analysis included OS stratified by solid tumor subtypes and prior lines of therapy. Results: After matching, patients with baseline lymphopenia …

Development Of The Core Lit Apparatus For Seaweed Hatcheries (Clash) Bioreactor Using A Germplasm Approach, Phillip O. Tahimic

Cal Poly Humboldt theses and projects

In comparison to the Asian aquaculture industry, the United States has minimal seaweed production. There are several drivers of the limited industry in the US, such as regulatory constraints and limited market demand, but the ability to scale is a considerable barrier to commercialization. One possible solution is the development of land-based systems that integrate bioreactors, which utilize fewer resources and do not wholly rely on an oceanic flow-through system. This study assessed the application of a modular bioreactor, known as Core Lit Apparatus for Seaweed Hatcheries (CLASH), as a nursery system and open-source project designed to expand land-based seaweed …

Nutrient-Driven Transcription Factor-Dna Interactions And Their Signaling Mechanisms In Metabolic Disease, Evelyn A. Bates

Theses and Dissertations--Nutritional Sciences

Metabolic homeostasis is maintained through tightly coordinated signaling networks that integrate diverse physiological inputs. Central to this regulation are transcription factors, which sense nutrient, hormonal, and vitamin-derived signals and translate them into coordinated gene expression programs. Transcription factor activity is governed by DNA binding, recruitment of coregulatory proteins, and interactions with specific response elements in gene promoters, which allows them to selectively modulate diverse metabolic pathways. Owing to their multifactorial and tunable nature, transcription factors have emerged as promising targets for the treatment and diagnosis of metabolic diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). This dissertation explores the molecular …

The Effect Of Second-Order Slip In Hydromagnetic Eyring-Powell Flow: A Bvp4c Study, Ch. Maheswari, B. Naga Lakshmi, G. Dharmaiah, R. Mohana Ramana, B. Reddappa

Mansoura Engineering Journal

The steady-state Eyring–Powell boundary layer fluid flow past a moving surface is examined, considering various parameter implications. These include the wall mass transfer parameter (0.5  C   2.0), the magnetic field parameter (5  Mn 20), the velocity ratio parameter (0.1  λ1  0.7), Eyring-Powell fluid parameters (0.5 K 2 & 0.1 E 0.4), as well as the first-order velocity slip (0.1 γ 1.1) and second-order velocity slip (0.1 δ  0.4). By employing appropriate similarity transformations, the PDEs are reduced to a set of non-linear ODEs, which are subsequently solved using the bvp4c numerical technique and, an implication of key factors on shear …

A Hybrid Geoid Model For The Perlis Region, Malaysia Based On Cadastral Reference Marks And A Geometric Approach, Muhammad Aiman Haiqal Abdul Malek, Muhammad Faiz Pa’Suya, Ramazan Alpay Abbak, Ami Hassan Md Din, Noorfatekah Talib

Mansoura Engineering Journal

This study presents the development of a high-resolution local geoid model for the Perlis region, Malaysia, using a geometric approach that integrates GNSS-levelling benchmarks with Cadastral Reference Mark (CRM) data. A total of 38 GNSS-levelling benchmarks were used as reference points, while 3,725 CRMs were incorporated to significantly enhance spatial coverage for geoid modelling. Orthometric heights at the CRM points were first determined by transferring heights from the reference benchmarks using gravimetric geoid information. Subsequently, geometric geoid heights were computed from the differences between ellipsoidal and orthometric heights. Five interpolation techniques were evaluated to generate the geometric geoid surface, namely …

Optimal Design Of Concrete Canal Section For Minimizing Overall Costs Using Artificial Ecosystem Optimization, Aya M. Elkhouly, Hamdy A. El-Ghandour, Tharwat Sarhan, Mahmoud E. Abd-Elmaboud

Mansoura Engineering Journal

The optimal design of concrete-lined canals represents a critical challenge in hydraulic engineering, requiring simultaneous minimization of construction and operational costs while satisfying hydraulic performance constraints. This study presents a novel optimization framework that utilizes the Artificial Ecosystem-based Optimization (AEO) algorithm for determining optimal canal cross-sectional dimensions. The proposed methodology comprehensively considers excavation costs, lining expenses, and water losses due to seepage and evaporation while ensuring hydraulic efficiency through velocity and Froude number constraints. The AEO algorithm mimics natural ecosystem processes through production, consumption, and decomposition phases to efficiently explore the design space and converge to global optima. The framework …

An Analysis Of Systemic And Contact Herbicide Usage Trends In Illinois Corn Production Systems, Paige E. Mckittrick

Murray State Theses and Dissertations

Herbicide use is central to weed management in Illinois corn production; however, long-term changes in the balance between systemic and contact herbicides have not been well quantified at the statewide scale. This study analyzes herbicide trends in Illinois corn from 1982 to 2016 using secondary data from the USDA Agricultural Chemical Use Survey, paired with climate, regulatory, and herbicide resistance information. Herbicide active ingredients were classified into systemic and contact functional categories and grouped according to Weed Science Society of America (WSSA) mode-of-action (MOA) codes. For each survey year, total herbicide load (lb a.i./acre), functional proportions, MOA-specific contributions, and a …

Do Magnesium Ions Have Similar Effects As Calcium Ions On Resting Membrane Potential?, Anthony Hana, Youngwoo Kim, Joy Bidros, Katie Neglia, Robin L. Cooper

Biology Faculty Publications

Maintaining a membrane electrical potential of biological cells is a dynamic process, as some cells have a continually changing potential, like pacemaker cells, while other cells may function with large or small changes in the membrane potential. Additionally, some cells may change their electrical potential when stimulated or inhibited by electrical signals, chemical compounds, or both—either simultaneously or episodically. The persistent leak of K⁺ through two-pore-domain potassium channels (K2P) and of Na⁺ through Na⁺ leak channels (NALCNs) and the action of pumps and exchangers are primarily responsible for maintaining a resting potential. Ca²⁺ ions are known …

Evolution Of A Novel Neuronal Sex-Specifically Spliced Gene In Mosquitoes, Yael Norohasimbola Tsitohay

Student Theses and Dissertations

Female mosquitoes from many species require a blood meal from an animal host as a protein source for egg development and successful reproduction. The majority of mosquito species are generalists in their host preference, feeding on a range of animals including mammals, birds, and amphibians. However, a small fraction of mosquito species have evolved a preference for human hosts. These species are mainly found in the genera Aedes, Culex, and Anopheles, and they have created a global health crisis due to their ability to transmit deadly human pathogens including dengue virus, Zika virus, West Nile Virus, and …

The Influence Of Dna Methylation On Both H2a.Z Nucleosome Dynamics And The Zinc Finger And Homeoboxes Transcription Factor Family, Rochelle M. Shih

Student Theses and Dissertations

DNA methylation represents a widespread and heritable modification that exerts substantial influence on chromatin organization and function in many eukaryotic genomes. The presence of DNA methylation has been strongly linked to transcriptional regulation, in both activating as well as repressive ways, though exactly how a small chemical mark can enact such drastic and seemingly opposing effects on gene expression remains an open question. In my thesis work, I describe the influence DNA methylation has on two classes of chromatin proteins, the histone variant H2A.Z and the Zinc Finger and Homeoboxes (ZHX) family of transcription factors. DNA methylation and H2A.Z preferentially …

Structural And Functional Studies Of The Sars-Cov-2 Niran Domain, Gabriel I. Small

Student Theses and Dissertations

The COVID-19 pandemic was a dramatically disruptive event, wreaking devastation across the globe and radically impacting nearly every facet of human life. For the first time, a significant amount of global money and attention was directed at coronavirus (CoV) research, propelling the field to the forefront of biomedical research. This allowed for the rapid development of a suite of vaccines and antivirals targeting SARS-CoV-2 that aided in ameliorating the effects of the pandemic. SARS-CoV-2 was the third CoV zoonosis of the 21st century and is now endemic. Global understanding of the threats posed by CoVs circulating among animals in the …

Urban Trees In The Urban Hydrology Cycle, Jorge R. Vera

Theses, Dissertations and Capstones

In urban forestry, trees provide numerous economic, ecological, and aesthetic benefits to the surrounding community. One of their key roles is intercepting stormwater runoff, reducing flooding risk, and improving water quality. Chapter 1 of this thesis characterized the ecological and economic contributions of urban trees on the Marshall University campus and provides guidance on their management and conservation in the future. Chapter 2 examined how urban tree species modify the urban hydrology cycle by altering the volume and timing of precipitation delivery. In Chapter 1, we inventoried 114 acres of Marshall University's main campus in Huntington, WV, from June 28 …

Surveillance Of A Novel Vesivirus Discovered In An Urban Mephitis Mephitis Population, Amanda E. Diggins

Honors Theses and Capstones

Caliciviridae is a family of non-enveloped, positive-sense, single stranded RNA viruses, including eleven defined genera that contain important pathogens of humans and animals. Within the Caliciviridae family, the genus Vesiviridae includes feline calicivirus, a leading cause of upper respiratory disease in cats, and vesicular exanthema of swine virus, a historical disease of domestic swine that has now been implicated in several marine mammal vesicular diseases, one of which has been confirmed zoonotic. Urban landscapes create a unique environment for rapid intra- and interspecies transmission of viruses. Clustered resources attract high-density populations of synanthropic wildlife species, increasing spatial overlap and heightening …

Fgf Signaling Is Necessary For Newt Lens Regeneration, Leo Alexander Napoleon

Honors Theses and Capstones

The Iberian ribbed newt Pleurodeles waltl can regenerate the lens by transdifferentiating iris pigmented epithelial (IPE) cells into lens epithelial cells (LECs), but the mechanism by which this occurs remains largely uncharacterized. We aim to mechanistically show an early and critical role for FGF signaling by using small molecules to inhibit FGF receptors and observe the histological and intracellular effects. Two inhibitors were found to completely stall lens regeneration. Cell cycle analysis revealed decreased DNA synthesis and uniformly low but unchanged entry to mitosis under signaling inhibition by staining for EdU incorporation and phospho-histone H3 (pH3), respectively. Western blot revealed …

Stress And Reward Interactions In Substance Use Disorder: An Evolutionary Mismatch Framework, Nicholas L. Castrucci

Honors Theses and Capstones

Substance use disorder (SUD) is a major public health concern characterized by compulsive substance use despite adverse consequences. While contemporary models emphasize biological, psychological, and environmental contributors, stress- and reward-related systems are often examined in isolation. This review integrates these systems within an evolutionary mismatch framework to examine how chronic stress exposure and repeated substance use increase vulnerability to addiction. Stress and reward systems are evolutionarily conserved but may become chronically dysregulated under modern conditions characterized by persistent psychosocial stressors and highly potent rewarding stimuli. This is associated with converging neuroadaptations across stress and reward circuitry, resulting in altered affective …

Toxic Torts Are In Your Blood: An Examination Of Pfas And Tort Liability, Aiden M. Holden

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Abstract

Per- and polyfluoroalkyl substances (PFAS), are a group of chemicals widely manufactured for industrial and commercial applications in the past decade due to their remarkable stability. Despite the “useful” nature of PFAS in various applications, they represent one of the most profound environmental and public health crises of the modern era. The chemical stability of PFAS has made them almost completely resistant to natural degradation, earning them the moniker “forever chemicals.” PFAS forever haunt our plant, contaminating the soil, water, and the blood of approximately 95% of the United States population. As the scale of corporate malfeasance by chemical …

Znf16 Is A Nucleolar-Associated Protein That Regulates Expression Of Rdna And Cancer-Associated Genes, Chelsea L. George, Laura A. Espinoza Quevedo, Jason Paratore, Matthew J. Alcaraz, Arlene P. Levario, Yasir Rahmatallah, Galina V. Glazko, Nathan S. Reyna, Laura Diaz-Martinez

Biology Faculty Scholarship

ZNF16 (also known as HZF1 and KOX9) is a multi-C2H2 zinc finger protein first identified via its expression in human T-cells and shown to have a role in blood cell differentiation. ZNF16 was later shown to be ubiquitously expressed in a variety of fetal and adult tissues, suggesting a broader function. In this study, we confirm the ubiquitous expression of ZNF16 in a variety of cancer and non-cancer cell lines and show that ZNF16 depletion reduces cell viability in all cell lines tested. Furthermore, we show that ZNF16 localizes to the nucleolus in a transcription-dependent manner, interacts with the intergenic …

Role Of Foxl2 Immunohistochemical Marker In Diagnosis Of Ovarian Sex Cord-Stromal Tumors, Correlation With Histopathologic Features And Inhibin Expression, Eman Magdi Hikal, Sylvia Albair Ashamallah, Nadia Abd El-Moniem Nada, Dina Abdallah Ibrahim

Mansoura Medical Journal

Background: Ovarian Sex Cord-Stromal Tumors (SCST) are a broad category of rare neoplasms that exhibit diagnostic challenges. Alpha-inhibin has been traditionally used as immunohistochemical marker (IHC) for SCST, but restrictions as lack of specificity and variability of cytoplasmic staining evolved.  Forkhead box L2 (FOXL2) is one of the earliest markers of ovarian differentiation and is essential for the normal development of granulosa cells and has been identified to be a sensitive and specific marker of Sex Cord-Stromal differentiation.

Aim: Assess FOXL2-IHC expression in different types of SCSTs and correlate its expression with histopathological features and Inhibin-IHC.

Methods: …