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The Cobalt Curse: Cobalt’S Role And Risks, Marley Jackowitz May 2026

The Cobalt Curse: Cobalt’S Role And Risks, Marley Jackowitz

Student Theses 2015-Present

This paper examines the hidden environmental, geopolitical, economic, and social costs of the cobalt supply chain. Fueled by the demand for battery technology and electric vehicles, cobalt has become an essential element to the green energy transition. With the largest share of global cobalt deposits, the Democratic Republic of the Congo bears a disproportionate share of the industry’s harms. Cobalt mining in the DRC is marked by environmentally degrading practices and inhumane working conditions, compromising Congolese health, safety, and well-being. Chapter 1 discusses the environmental impacts of DRC cobalt mining and its adverse effects on public health. Environmentally degrading mining …


Consumerism In The Digital Age: Environmental And Cultural Consequences, Danielle Andrea Montoya May 2026

Consumerism In The Digital Age: Environmental And Cultural Consequences, Danielle Andrea Montoya

Student Theses 2015-Present

Overconsumption has emerged as a significant environmental problem, characterized by persistent patterns of buying, using, and discarding goods at rates that exceed ecological limits. In the digital age, these patterns of consumption are reinforced by economic systems, technological advancements, and cultural norms that make constant consumption feel normal and convenient. While consumption is necessary for everyday life, consumption beyond basic needs contributes to increased waste, resource depletion, pollution, and climate change. Overconsumption is embedded in daily habits such as online shopping, food consumption, and frequent product replacement. Therefore, understanding and addressing overconsumption is crucial for achieving environmental sustainability and social …


How Does Five Days Of Tapering Effect Rates Of Fatigue And Recovery In Collegiate Male Swimmers?, Riley Yerks May 2026

How Does Five Days Of Tapering Effect Rates Of Fatigue And Recovery In Collegiate Male Swimmers?, Riley Yerks

Celebrating Scholarship and Creativity Day (2018-)

This study was conducted on the members of the 2025-26 St. John's "Johnnies" swim and dive team. This study used both subjective surveys and objective HRV readings that the swimmers took before and after practice. The first day of testing occurred on the last day of the regular training season, and the second day of testing occurred on the last day of tapered training. Results of the surveys and HRV readings were compared between pre and post-practice, and pre and post-taper. The subjective surveys showed how the swimmers themselves felt in terms of physical and mental energy and fatigue, and …


The Influence Of Valence On Action Control: A Comparison Of Simon Effects In The Extrinsic Affective Simon Task (East) And The Spatial Simon Task, Yaara Aleissa May 2026

The Influence Of Valence On Action Control: A Comparison Of Simon Effects In The Extrinsic Affective Simon Task (East) And The Spatial Simon Task, Yaara Aleissa

College of Arts & Sciences Senior Theses

People adjust their thoughts and actions in response to a changing environment every day and emotions may influence these actions. Understanding how emotion impacts action control in situations where emotion is central to the action (task-relevant) compared to when it is present in the environment as distracting information (task-irrelevant) is essential. Currently it is unclear when emotion most significantly modulates action control. This study seeks to compare how valence (positive versus negative emotion) impacts action control performance when valence is task-relevant and task-irrelevant by using two modified versions of the Simon conflict task.

The Simon task is a paradigm to …


Volume 17, Christian O’Neill, Kyara Greene, Savva Sidorov, Laura Bisaillon, Luke Clemmer, Hannah Gordon, Kitt Benson, Taylor Blount, Rachel Danzitz, Nicholas Duellman, Chase Gionis, Hima Fernando, Seth Franzyshen, Onyx Gonzalez, Bryan Lin, Samantha Start, Ysabel Wells, Maggie Duncan May 2026

Volume 17, Christian O’Neill, Kyara Greene, Savva Sidorov, Laura Bisaillon, Luke Clemmer, Hannah Gordon, Kitt Benson, Taylor Blount, Rachel Danzitz, Nicholas Duellman, Chase Gionis, Hima Fernando, Seth Franzyshen, Onyx Gonzalez, Bryan Lin, Samantha Start, Ysabel Wells, Maggie Duncan

Incite: The Journal of Undergraduate Scholarship

Introduction Dr. Amorette Barber, Director, Office of Student Research

From the Editor Dr. Hannah Dudley-Shotwell

Cover Artist’s Statement Maggie Duncan

On Mentoring Dr. Yulia Uryadova

Ukrainian Resistance in the Face of Russification: Nestor Makhno and Anarchism

by Christian O’Neill

Life Vest by Kyara Greene

Isolation and 16S rRNA Identification of Bacteria from Fire Department Connection Pipe by Savva Sidorov

The Effectiveness of Planned Exercise in Reducing ADHD Symptoms in Children by Laura Bisaillon & Luke Clemmer

Linguistic Analysis on Confidence and Communication Strategies with Disparities Between Sign Fluency and Hearing Impairment by Hannah Gordon

Freedmen in Indian Territory by Kitt …


Species Diversity And Estimation Of Aboveground Carbon Stocks In Sugar Palm Forest And Lowland Forest In Negeri Hatusua, Maluku, Irwanto Irwanto, Andjela Sahupala, Febian Tetelay, Yulianus Komul May 2026

Species Diversity And Estimation Of Aboveground Carbon Stocks In Sugar Palm Forest And Lowland Forest In Negeri Hatusua, Maluku, Irwanto Irwanto, Andjela Sahupala, Febian Tetelay, Yulianus Komul

Jurnal Penelitian Kehutanan Wallacea

Tropical forests are essential for climate change mitigation, but limited data on species diversity and aboveground carbon stocks in Indonesia constrain evidence-based forest management. This study aims to assess species diversity and aboveground carbon stocks in sugar palm forests and lowland forests in Negeri Hatusua, Maluku Province, Indonesia. Vegetation analysis was employed to determine species structure and diversity, while carbon stock measurement and calculation followed the Indonesian National Standard (SNI 7724:2019) for land-based carbon assessment, with certain modifications. The results indicated that the species diversity index in the sugar palm forest was 2.21 for trees, 1.95 for poles, 2.26 for …


Site Characterization And Integrated Irrigation-Forestry Solutions For Mangrove Restoration In The Red River Delta Biosphere Reserve, Vietnam, Manh Quy Do, Huy Quoc Nguyen, Minh Duc Nguyen, My Tra Ha, Tuan Anh Le, Luan Thanh Nguyen, Tu Ngoc Pham May 2026

Site Characterization And Integrated Irrigation-Forestry Solutions For Mangrove Restoration In The Red River Delta Biosphere Reserve, Vietnam, Manh Quy Do, Huy Quoc Nguyen, Minh Duc Nguyen, My Tra Ha, Tuan Anh Le, Luan Thanh Nguyen, Tu Ngoc Pham

Jurnal Penelitian Kehutanan Wallacea

The research was conducted in 2023 in a degraded mangrove forest area in Giao Hoa commune, Ninh Binh province, Vietnam. This area is part of the Red River Delta Biosphere Reserve (RRDBR), which was recognised by UNESCO in 2004. The study employed methods such as surveying topographical features, assessing soil and water characteristics, and evaluating the status of the mangrove forest. It also used GIS and The Analytic Hierarchy Process method to analyse and evaluate the current condition of the forest and its site characteristics. The research results show that, regarding the topographical features of the degraded mangrove area, it …


Cyanine Dyes As Next-Generation Fluorophores: Applications In Cell Sorting And Fingerprinting Technologies, Super-Multiplexed Spectroscopy, Biomedical Imaging, And Beyond, Lucas Allen Davis May 2026

Cyanine Dyes As Next-Generation Fluorophores: Applications In Cell Sorting And Fingerprinting Technologies, Super-Multiplexed Spectroscopy, Biomedical Imaging, And Beyond, Lucas Allen Davis

Undergraduate Honors Thesis Collection

As biochemical, pharmaceutical, and medical sciences advance, the demand for technologies capable of probing multiple cellular targets simultaneously continues to increase. Super-multiplexed spectroscopic techniques offer a pathway toward comprehensive cellular fingerprinting by overcoming the spectral limitations of conventional fluorescence labeling. By circumventing the traditional “color barrier,” cyanine-based Raman tags enable the simultaneous discrimination of numerous cellular morphologies, allowing spectroscopy and imaging to be integrated for high-dimensional cellular analysis. Technologies developed in Goda Lab—including high-throughput flow cytometry, virtual freezing fluorescence imaging (VIFFI), Fourier-transform coherent anti-Stokes Raman spectroscopy (FT-CARS), and MERdot nanoparticles—address longstanding trade-offs between throughput, resolution, sensitivity, and multiplexing capacity. Central …


The Effects Of Heat Stress On White Blood Cell Profiles And Antibody Concentrations In Broilers Genetically Selected For Low Water Conversion Ratio Compared To The Modern Random Bred Broiler, Luke B. Janski May 2026

The Effects Of Heat Stress On White Blood Cell Profiles And Antibody Concentrations In Broilers Genetically Selected For Low Water Conversion Ratio Compared To The Modern Random Bred Broiler, Luke B. Janski

Poultry Science Undergraduate Honors Theses

Heat stress (HS) is one of the most significant environmental stressors impacting poultry production worldwide, reducing growth, feed efficiency, welfare, and immune competence. With global temperatures rising, understanding physiological and immunological adaptations to HS is essential for sustainable production. Broiler chickens selectively bred for low water conversion ratio (LWCR) have shown potential for reduced water consumption under environmental challenges; however, their immune resilience under HS conditions compared with modern random-bred (MRB) broilers remains unclear. This study investigated the effects of cyclic HS on red- (RBC) and white- (WBC) blood cells and humoral immunity in LWCR and MRB broilers. Birds were …


Evaluation Of Flt3 Inhibition With Quizartinib During Busulfan Conditioning For Hematopoietic Stem Cell Transplantation, Catherine Jankovic May 2026

Evaluation Of Flt3 Inhibition With Quizartinib During Busulfan Conditioning For Hematopoietic Stem Cell Transplantation, Catherine Jankovic

Biochemistry and Molecular Biology

Hematopoietic stem cell transplantation (HSCT) is one of the only curative therapy options for many hematologic malignancies. HSCT relies on effective conditioning regimens to deplete host hematopoietic cells and enable donor engraftment. The alkylating agent Busulfan is widely used in myeloablative conditioning strategies due to its potent cytotoxic effects on hematopoietic cells and ability to clear the bone marrow. However, optimization of conditioning strategies remains an important area of investigation to improve transplant outcomes and reduce toxicity. Preliminary studies have shown that the FLT3 inhibitor Quizartinib synergizes with some chemotherapeutic agents, suggesting that targeted inhibitors may enhance conventional conditioning regimens. …


Bottles, Butterflies, And Biomass: Recycled Glass Sand, Microbial Additions, And Herbivory Effects On Milkweed Growth, Kealey Skinner May 2026

Bottles, Butterflies, And Biomass: Recycled Glass Sand, Microbial Additions, And Herbivory Effects On Milkweed Growth, Kealey Skinner

Honors Theses

Plant-soil-microbe interactions are integral components of ecological networks and drive ecosystem function from the bottom-up. Whereas herbivores regulate ecosystem function from the top-down, having opposing and potentially complementary effects on ecosystem function. My thesis sought to understand how below-ground microbial communities contribute to herbivore preference and plant biomass across varied soil substrates. My thesis asked: how do substrate and soil microbial communities influence herbivore preference and plant biomass accumulation on swamp milkweed (Asclepias incarnata)? To address this question, seedlings of A. incarnata were sown in 2.5 cm wide × 10 cm deep pots filled with either natural beach sand or …


Exploring The Spectrum Of Anxiety During Concussion Recovery: A Comprehensive Examination Of Symptom-Based Anxiety Disorders, Kori J. Durfee May 2026

Exploring The Spectrum Of Anxiety During Concussion Recovery: A Comprehensive Examination Of Symptom-Based Anxiety Disorders, Kori J. Durfee

Graduate Theses and Dissertations

Background: Anxiety is common following a concussion, arising from both psychosocial and physiological changes, and can manifest in diverse ways. Despite its complexity and association with worse outcomes, post-concussion anxiety is often assessed as a single construct. Characterizing anxiety presentations following injury may improve the identification of clinically meaningful symptoms and help inform future targeted interventions that can improve concussion outcomes. Purpose: The primary purpose was to determine if symptom-based anxiety disorders occur in adults with concussion and identify pre- and post-injury predictors associated with these disorders. Additionally, the clinical utility and predictive abilities of symptom-based anxiety disorders and variability …


Aggregation And Collation Of Texas Crayfish Museum Specimens To Determine Their Current Conservation Statuses, Adrian Alvarez May 2026

Aggregation And Collation Of Texas Crayfish Museum Specimens To Determine Their Current Conservation Statuses, Adrian Alvarez

Biology Theses

Crayfish account for over half of the macroinvertebrate biomass in many ecosystems and serve as crucial bioindicators because of their behavioral and physiological adaptability to environmental changes. Despite being home to approximately 52 native crayfish species, Texas currently lacks protective regulations. This gap is primarily because of insufficient information regarding their distribution and occurrences within the state, including their statuses as Species of Greatest Conservation Need (SGCN). This study focuses on compiling and comparing crayfish museum records with current iNaturalist field survey data across Texas to address these knowledge gaps and recommend updates to SGCN statuses. Five species not currently …


Sorghum Grain Secondary Metabolites And Underlying Genetics To Reduce Foodborne Pathogens In Poultry, Maria A. Conti May 2026

Sorghum Grain Secondary Metabolites And Underlying Genetics To Reduce Foodborne Pathogens In Poultry, Maria A. Conti

All Dissertations

The rise in antibiotic-resistant pathogens poses a threat to the poultry industry's ability to maintain animal health, prompting growing interest in alternatives to synthetic antibiotics. The use of non-tannin sorghum [Sorghum bicolor (L.) Moench] in poultry rations offers a valuable alternative, as this cereal grain has a high bioactive profile that can provide health benefits, including antimicrobial (AM) activity. The scope of this study was to examine the AM potential of non-tannin sorghum grain against Clostridium perfringens, a major foodborne pathogen that negatively impacts poultry health and production. To that end, the inhibitory effects of a non-tannin sorghum …


Enrichment Of The Thermophilic Archaea Gearchaeales And Calditenuis In Lab Culture, Walter Saldivar May 2026

Enrichment Of The Thermophilic Archaea Gearchaeales And Calditenuis In Lab Culture, Walter Saldivar

Electronic Theses, Projects, and Dissertations

Numerous microbes on Earth have yet to be grown in pure cultures and studied in the laboratory. Cultivation-independent genomic methods, such as metagenomics, can help us predict their metabolic capabilities, but cultivation remains valuable for testing these predictions. These uncultivated microbes are very diverse, especially within hot springs. Examples of these uncultivated microbes include the genus Calditenuis (formerly Aigarchaeota Group 1) and the order Gearchaeales; they are often abundant in terrestrial hot springs such as Great Boiling Springs (GBS) in Nevada. Previous work allowed for the establishment of laboratory enrichment cultures inoculated from sediments of GBS containing Calditenuis and …


Fisheries Management Paper No. 313: Western Australian Statewide Small Pelagic Scalefish Resource Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia May 2026

Fisheries Management Paper No. 313: Western Australian Statewide Small Pelagic Scalefish Resource Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Management Papers

Harvest strategies for Western Australia’s (WA) aquatic resources are formal documents developed by the Department of Primary Industries and Regional Development (DPIRD, the Department) to support decision-making processes that ensure the outcomes are consistent with the principles of Ecologically Sustainable Development (ESD; Fletcher 2002a) and Ecosystem Based Fisheries Management (EBFM; Fletcher et al. 2012).

Harvest strategies are a key component of all contemporary fishery management systems and a requirement for certification under the Marine Stewardship Council (MSC; Marine Stewardship Council 2018). The objectives of ESD are reflected in the objects of the Fish Resources Management Act 1994 (FRMA).

This Statewide …


Three Essays On Veterinary Drug Maximum Residue Limits, Akinbode Okunola May 2026

Three Essays On Veterinary Drug Maximum Residue Limits, Akinbode Okunola

Department of Agricultural Economics: Dissertations, Theses, and Student Research

This dissertation consists of three essays: the first examines the prevalence of veterinary drug maximum residue limits (MRLs), the regulatory behavior of countries in setting these MRLs, and the degree of country-level compliance with international standards of Codex Alimentarius (Codex). The second evaluates the extent to which compliance with international standards across countries can help to manage potential transmission of resistant bacterial from animals to humans through consumption of contaminated meat, dairy and aquaculture products. The third focuses on how differences in regulatory standards across countries can impact international trade in the global beef, pork, and poultry markets.

The first …


Developing A Protocol For Non-Cellular Transplantation Of Donor Mitochondria Into Recipient Cells, Andrew Parton May 2026

Developing A Protocol For Non-Cellular Transplantation Of Donor Mitochondria Into Recipient Cells, Andrew Parton

Honors Theses

Tumor innervation has emerged as a critical feature of cancer progression, with increased nerve density correlating with enhanced aggressiveness, metastatic dissemination, and poor clinical outcome. However, the functional contribution of neurons to tumor biology remains incompletely defined. We recently identified the intercellular transfer of mitochondria from neurons to cancer cells as a mechanism that promotes tumor progression. We therefore hypothesized that disruption of this transfer could attenuate tumor aggressivity. To directly investigate this process, we developed an approach to isolate mitochondria from donor cells and transplant them into recipient cancer cells independently of canonical cell-cell interactions. Transferred mitochondria were tracked …


Revised - The Role Of Gad67/65 In The Therapeutic Effects Of Ketamine And Fluoxetine In Fear-Conditioned Mice, Alex G. Ottimer May 2026

Revised - The Role Of Gad67/65 In The Therapeutic Effects Of Ketamine And Fluoxetine In Fear-Conditioned Mice, Alex G. Ottimer

All NMU Master's Theses

Post-traumatic stress disorder (PTSD) is a chronic psychiatric disorder and the most common disorder following exposure to a traumatic event. The most commonly used drugs in PTSD treatment are selective serotonin reuptake inhibitors (SSRIs), though only about 50% of patients respond to this treatment. Previous work in our lab demonstrated the combination of chronic fluoxetine (FLX) and acute ketamine treatment decreased fear response in a contextual fear paradigm in male C57/BL mice. In rodents, fear conditioning (FC) is commonly used in the literature to induce behaviors related to PTSD. The mammalian central fear memory circuit involves a dynamic interplay between …


A Q-Methodology Study Of How Viewers Within The Southeastern Circuit Perceive The Future Of The Western Sports Industry, Molly Mckettrick May 2026

A Q-Methodology Study Of How Viewers Within The Southeastern Circuit Perceive The Future Of The Western Sports Industry, Molly Mckettrick

Graduate Theses and Dissertations

Western Sports occupy a unique position within American Culture, reflecting traditions rooted in agricultural communities and livestock practices, while also evolving as contemporary spectator events. Despite the growing visibility of Western Sports through media coverage on various digital platforms, there is limited research on how general audiences perceive the sport, which is the purpose of this study: to examine how viewers perceive the sport. This study examines viewer perspectives regarding the sport across various digital platforms, due to limited research on how general audiences perceive the sport while employing Q-Methodology to identify shared perspectives among spectators. A total of forty …


Conservation Wins And Woes: A Meta-Synthesis Of Ecotourism Impacts On Primates And Local Communities, Madison Lanie Mckinniss May 2026

Conservation Wins And Woes: A Meta-Synthesis Of Ecotourism Impacts On Primates And Local Communities, Madison Lanie Mckinniss

Graduate Theses and Dissertations

Biodiversity assessments identify 612 extant species of primate, but ~50% of these species are at risk of extinction. Threats include agricultural and industrial production, urban development, and poaching. As concerns have grown regarding impacts on the environment, researchers have proposed ecotourism as a tool for conserving ecosystems while improving human welfare. Although conservation initiatives are pursued at these ecotourist sites, the presence of humans can cause additional influences on non-human primates (NHP). Primatologists have posed questions regarding implications of ecotourism on NHP, but research remains scarce. This study will investigate the practices executed at ecotourist sites where endemic NHPs reside. …


Ecological Insights And Management Implications Of The Global Migratory Connectivity Of Green Turtles, Jaime Restrepo, Dina Nisthar, Harris Wei-Khang Heng, Lily K. Bentley, Corrie Curtice, Sarah Deland, Ei Fujioka, Patrick N. Halpin, Sarah K. Poulin, Roldán A. Valverde May 2026

Ecological Insights And Management Implications Of The Global Migratory Connectivity Of Green Turtles, Jaime Restrepo, Dina Nisthar, Harris Wei-Khang Heng, Lily K. Bentley, Corrie Curtice, Sarah Deland, Ei Fujioka, Patrick N. Halpin, Sarah K. Poulin, Roldán A. Valverde

School of Earth, Environmental, & Marine Sciences Faculty Publications

Aim

Green turtles are a widely distributed and highly migratory species; despite extensive data on their movement, there is no species-specific global synthesis on the subject. Based on three decades of published literature and building on previous global analyses, we developed a global network model of migratory connectivity for green turtles to better understand their spatial biology.

Location

Global.

Time Period

1990–2022.

Major Taxa Studied

Green Sea Turtle (Chelonia mydas).

Methods

We conducted a structured literature review extracting georeferenced information on the movement of green turtles from 1990 to 2022, aggregating this information into a single connectivity model, …


Sensing Rna’S Conformation With A Solid-State Nanopore Device At Various Ph And Temperature, Haopeng Li May 2026

Sensing Rna’S Conformation With A Solid-State Nanopore Device At Various Ph And Temperature, Haopeng Li

Graduate Theses and Dissertations

This study uses solid-state nanopore technology to investigate the stability and dynamics of RNA molecules under thermal stress and pH fluctuations. Two distinct mRNA samples were analyzed: (1) heat shock protein (HSP)-encoding mRNA extracted from Sulfolobus solfataricus P2, a thermophilic archaeon inhabiting extreme environments such as geothermal sulfuric hot springs (pH < 4, temperature range: 65–90°C), and (2) total RNA extracted from White Leghorn chickens, which thrive under standard physiological conditions. ΦX174 virion single-stranded DNA (ssDNA) were included as a comparative reference. Nanopores, fabricated in silicon nitride membranes, were used to electrically characterize the structural properties of individual RNA molecules in solution, close to their native environments. The nanopore membrane separates two chambers containing salt buffer solution, where ionic current is the primary measurement parameter. When a voltage bias is applied across the membrane, ion flow and an ionic current can be measured. Charged RNA molecules driven translocation through the nanopore induces pore resistance changes, resulting in detectable current blockade events. Variations in these events provide insights into RNA secondary structure and conformational dynamics. By systematically altering pH and temperature, this study elucidates the effects of environmental stressors on RNA stability and structural integrity. The findings reveal distinct responses between thermophilic HSP-encoding mRNA and mesophilic RNA, underscoring the adaptive mechanisms of thermophilic RNA under extreme conditions. These results contribute to a better understanding of RNA behavior under stress and establish a foundation for future applications in RNA-based diagnostics and biotechnology development.


Rehumanizing Anatomized Individuals: Using Osteobiographies As A Step Towards Reparative Justice, Lillie C. Turpin May 2026

Rehumanizing Anatomized Individuals: Using Osteobiographies As A Step Towards Reparative Justice, Lillie C. Turpin

Department of Anthropology: Theses and Student Research

In 1985, India banned the export of human remains. This ended the major trade route for primarily US and European anatomical supply companies. Until this point, companies like Carolina Biological Supply exploited and erased vulnerable people's identities, molding them into anonymous anatomical specimens. This study investigates the life and postmortem history of twenty-five individuals, previously used as anatomical specimens, housed at the University of Nebraska–Lincoln. Using an osteobiographical approach, this research reconstructs aspects of these individuals' lived experiences and examines how anatomical preparation practices reflect structural violence and apathy.

Skeletal analysis of twenty-five individuals revealed a range of biological profiles, …


Bugs, Birds, Blue: Queer Ecologies Of Embodiment, Kinship, And Survival, Celeste B. Newcomb May 2026

Bugs, Birds, Blue: Queer Ecologies Of Embodiment, Kinship, And Survival, Celeste B. Newcomb

Theses and Dissertations

bugs, birds, blue is a multi-channel audiovisual installation that examines queer ecology as a framework for understanding transgender embodiment, kinship, and survival amid environmental crisis and ongoing political attacks on trans life (Mortimer-Sandilands and Erickson). Through sculpture, projection, sound, reflective surfaces, and biological imagery, the installation places human bodily matter alongside microbial and aquatic life forms to challenge narratives that frame trans existence as unnatural, recent, or isolated. Instead, the work proposes transness as relational, adaptive, and deeply entangled with broader ecological systems. The installation is composed of two interconnected environments. On one side of the space, three aquariums rest …


Genetic Screen For Regulators Of Pol4, A Dna Repair Polymerase In Saccharomyces Cerevisiae, Pasang Dolma Sherpa May 2026

Genetic Screen For Regulators Of Pol4, A Dna Repair Polymerase In Saccharomyces Cerevisiae, Pasang Dolma Sherpa

Theses and Dissertations

In Saccharomyces cerevisiae, DNA polymerase 4 (POL4) is the beta repair polymerase, the product of the POL4 gene, and is involved in base excision repair (BER) and microhomology-mediated end joining (MMEJ). Despite its involvement in these repair pathways and its conservation across eukaryotes, deletion of POL4 shows no detectable phenotype under standard laboratory conditions. I hypothesized that unknown genes act as backup systems, providing redundant activities that allow pol4Δ cells to survive. To test this, a genetic screen for mutants showing synthetic lethality with pol4Δ was implemented. I constructed a strain lacking the POL4 gene and carrying …


Reconstruction Of Fox Transcription Factor-Regulated Subnetworks Mediating Cardiac Progenitor Cell Divisions, Md Rezaul Hasan May 2026

Reconstruction Of Fox Transcription Factor-Regulated Subnetworks Mediating Cardiac Progenitor Cell Divisions, Md Rezaul Hasan

All-Inclusive List of Electronic Theses and Dissertations

Congenital heart disease (CHD) is the most common congenital anomaly worldwide, affecting approximately 1% of live births, corresponding to 1.35 million infants born with CHD each year, and remains a leading cause of infant mortality; therefore, it is urgent to understand the genetic and molecular mechanisms underlying CHD for advancing early diagnosis and treatment. Because many aspects of the Drosophila heart formation are highly reminiscent of vertebrate heart development, Drosophila melanogaster serves as a simple yet powerful model system for studying cardiac development and CHD. While at least eight Forkhead box (Fox) transcription factors (TFs) are required for proper cardiac …


Analysis Of Developmental Cardiogenic Processes Mediated By Fox And Zinc-Finger Transcription Factors, Rajnandani Katariya May 2026

Analysis Of Developmental Cardiogenic Processes Mediated By Fox And Zinc-Finger Transcription Factors, Rajnandani Katariya

All-Inclusive List of Electronic Theses and Dissertations

Cardiogenesis is a highly choreographed biological process requiring the precise integration of gene regulatory networks to govern cell division, fate determination, and spatial positioning. Disruptions in these mechanisms lead to congenital heart defects (CHDs), which affect approximately 1% of live births globally. Due to the evolutionary conservation of cardiac signaling pathways and the structural homologies between the Drosophila dorsal vessel and the early vertebrate heart tube, Drosophila melanogaster serves as a powerful model for dissecting the fundamental mechanisms of heart development. This dissertation investigates the molecular orchestration of cardiac development, specifically focusing on the roles of the transcription factors Jumu …


Trawling For Clues: Examining Nefmc Herring Amendment 8, Christopher Santoro May 2026

Trawling For Clues: Examining Nefmc Herring Amendment 8, Christopher Santoro

Honors Scholar Theses

In 2007, almost twenty years ago, the Magnuson-Stevens Act changed the landscape of fisheries management in the US. Through the establishment of Fisheries Management Councils (FMCs), it paved the way for top-down management approaches that helped the government combat nationwide declines or collapses in fish stocks. Among the myriad responsibilities of the FMCs was the expectation that amendments to existing fisheries management plans would be a necessity to adapt to modern circumstances. This thesis focuses on New England Fisheries Management Council's (NEFMC's) Herring Amendment 8 (A8). This amendment, passed in 2021, attempts to lay the groundwork for sustainable management of …


Unveiling The Biochemical Pathway Responsible For Ankyloglossia (Tongue-Tie) By Tracking Enzymatic Activity Of Apoptosis Pathways, Becca Ringstad May 2026

Unveiling The Biochemical Pathway Responsible For Ankyloglossia (Tongue-Tie) By Tracking Enzymatic Activity Of Apoptosis Pathways, Becca Ringstad

Celebrating Scholarship and Creativity Day (2018-)

Ankyloglossia (Tongue-tie) is a condition that is caused by failed cellular degeneration leading to a short lingual frenulum. This short lingual frenulum tethers the tongue to the bottom palate of the mouth and leads to problems, including breastfeeding for infants, depriving them of important proteins that build the gut microbiome, strengthen the immune system, and fight off antigens. If left untreated, it leads to problems with speech articulation, airway development, and obstructive sleep apnea. Treatment involves a frenectomy, which is the release of the short lingual frenulum using surgical scissors or a laser. Ankyloglossia can occur with conditions such as …