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Phrg-Rapg-Degu Quorum Sensing Regulates Menaquinone- 7 Production In Bacillus Subtilis, Junbao Huang, Xilin Huang, Yu Chen, Xuli Gao, Yani Luo, Wei Tao, Yongyuan Liu, Mingyu Guo, Jing Wu, Yan Liu May 2025

Phrg-Rapg-Degu Quorum Sensing Regulates Menaquinone- 7 Production In Bacillus Subtilis, Junbao Huang, Xilin Huang, Yu Chen, Xuli Gao, Yani Luo, Wei Tao, Yongyuan Liu, Mingyu Guo, Jing Wu, Yan Liu

Journal of Food Science and Biotechnology

[Objective ] The effects of the transcription regulation system on menaquinone- 7 (MK- 7) production in Bacillus subtilis (B.subtilis ) 168 were studied by excavating transcription regulators.[Method ] With the signal molecule PhrG pentapeptide,RapG,and the transcription regulator DegU,a PhrG-RapG-DegU regulatory system was successfully constructed in B.subtilis 168 to fine-tune the expression of key genes,so that the expression of key genes in the MK- 7 synthesis pathway can respond to the changes in cell density.[Result ] The production of MK- 7 in strain BS 06 reached 102.47 mg/L through this system.[Conclusion ] Fine tuning of quorum sensing can effectively improve the …

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Nutritional Components And Immunoregulatory Mechanisms Of Lactoferrin Formula, Mengying Zhou, Liujie Zheng, Ruiqing Yao, Hongyu Wu, Gangliang Hu, Zhengquan Huo, Yinhua Ni May 2025

Nutritional Components And Immunoregulatory Mechanisms Of Lactoferrin Formula, Mengying Zhou, Liujie Zheng, Ruiqing Yao, Hongyu Wu, Gangliang Hu, Zhengquan Huo, Yinhua Ni

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the immunoregulatory mechanisms of lactoferrin formula and its four nutritional components (α-lactalbumin,N-acetylneuraminic acid,yeast β-glucan,and lactoferrin ) in RAW 264.7 macrophages.[Method ] M1 and M 2 macrophage polarization were induced by lipopolysaccharides (LPS) and interleukin (IL)-4,respectively.Quantitative real-time PCR,flow cytometry,and Western blot were employed to analyze macrophage polarization and related signaling pathways.[Result ] Lactoferrin formula enhanced the phagocytic activity of macrophages and dose-dependently inhibited M 1 polarization while promoting M 2 polarization within the range of 10~50 µg/mL.A combination of four nutritional components exhibited similar effects,with greater effects than the three-component combination.Additionally,the lactoferrin formula upregulated …

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Isolation And In Vitro Inhibition Of Mycotoxin-Metabolizing Strains From Domestic Barley, Ran Qiu, Junhui Zhong, Xiaomin Chang, Lin Xiao, Yanlong Bai, Tengfei Yu May 2025

Isolation And In Vitro Inhibition Of Mycotoxin-Metabolizing Strains From Domestic Barley, Ran Qiu, Junhui Zhong, Xiaomin Chang, Lin Xiao, Yanlong Bai, Tengfei Yu

Journal of Food Science and Biotechnology

[Objective ] This study aims to assess the effects of Fusarium on the malting process and malt quality of barley,screen out the microorganism with inhibitory activity against Fusarium,and explore the potential of this microorganism for degrading deoxynivalenol (DON ).[Method ] The mycotoxin-producing strain was isolated from domestic Dan ’er barley contaminated with pathogenic fungi,and the interaction between the pathogen and the host was studied.The germination rate,water sensitivity,and DON mass fraction were compared between the barley infected for 5 d and standard barley.The DON mass fraction,activities of protease,β-glucanase,and amylase,and physicochemical indicators (free amino acids,soluble nitrogen,and β-glucan mass concentration ) of malt …

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Research Progress In Effects Of Bile Acids And Their Receptors On Intestinal Function, Lu Jin, Jiansheng Jin, Yongqiang Gu, Lulu Zhou, Feifei Han May 2025

Research Progress In Effects Of Bile Acids And Their Receptors On Intestinal Function, Lu Jin, Jiansheng Jin, Yongqiang Gu, Lulu Zhou, Feifei Han

Journal of Food Science and Biotechnology

Bile acids are the main end products of cholesterol metabolism in the body,playing an important regulatory role in the digestion and metabolism of nutrients,especially lipids.The intestine is the main organ for digestion and absorption,as well as an important site for bile acids to achieve liver-intestinal circulation.Its function is closely related to the interaction between bile acids as signaling molecules and their receptors.Focusing on the metabolism and regulatory mechanism of bile acids,the author reviews the roles and underlying mechanisms of bile acids and their receptors in regulating intestinal barriers,immune function,and gut microbiota.The aim is to provide reference for related research on …

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Antibiotic Resistance And Transmission Characteristics Of Enterococcus Faecalis From The Pork Production Chain In Hangzhou, Min Qian, Wei Zhou, Zhijin Zhou, Enbao Zhang, Jianzhong Han, Daofeng Qu May 2025

Antibiotic Resistance And Transmission Characteristics Of Enterococcus Faecalis From The Pork Production Chain In Hangzhou, Min Qian, Wei Zhou, Zhijin Zhou, Enbao Zhang, Jianzhong Han, Daofeng Qu

Journal of Food Science and Biotechnology

[Objective ] This study aims to evaluate the antibiotic resistance and transmission risk of Enterococcus faecalis (E.faecalis ) in the pork production chain.[Method ] A total of 300 samples were collected from the surface of live pigs,carcasses,and the environment in 2 pig farms,1 slaughterhouse,and 2 markets in Hangzhou,Zhejiang.The strain identification,antibiotic resistance phenotypes,resistance genotypes,and virulence genotypes were performed by 16S rDNA sequences,broth microdilution method (MIC ),and PCR.In addition,multilocus sequencing typing (MLST ) and conjugational transfer tests were conducted.[Result ] The 125 isolates of E.faecalis showed high resistance to antibiotics such as tiamulin,tetracycline,and doxycycline,and the isolates from pig farms showed higher antibiotic …

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Changes In Volatile Aldehydes Of Soymilk After Acid-Precipitation And Its Influencing Factors, Mapeizhan Lou, Caimeng Zhang, Xiangzhen Kong, Xingfei Li, Yeming Chen, Xiaoxiao Feng, Yufei Hua May 2025

Changes In Volatile Aldehydes Of Soymilk After Acid-Precipitation And Its Influencing Factors, Mapeizhan Lou, Caimeng Zhang, Xiangzhen Kong, Xingfei Li, Yeming Chen, Xiaoxiao Feng, Yufei Hua

Journal of Food Science and Biotechnology

[Objective ] Acid precipitation,a common method in plant protein processing,can efficiently achieve protein enrichment and removal of non-protein components (including off-flavor substances ) on a large scale.This study aims to explore the causes for the abnormal increases in aldehydes of soymilk after acid precipitation.[Method ] Changes in volatile compounds of soymilk before and after acid precipitation were analyzed by gas chromatography-mass spectrometry (GS-MS ).Soymilk components were fractionated by centrifugation,and the contributions of different fractions to the increases in aldehydes were investigated.The changes in the molar concentrations of lipid hydroperoxides before and after acid precipitation were determined,and a molar ratio between …

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Effects Of Lactobacillus Plantarum Fermentation On Flavonoids And Organic Acids In Mango Juice, Ying Yang, Dongdong Yang, Li Li, Xuemei He, Dongqing Ye May 2025

Effects Of Lactobacillus Plantarum Fermentation On Flavonoids And Organic Acids In Mango Juice, Ying Yang, Dongdong Yang, Li Li, Xuemei He, Dongqing Ye

Journal of Food Science and Biotechnology

[Objective ] This study aimed to investigate the effects of Lactobacillus plantarum (L.plantarum ) fermentation on the metabolism of flavonoids and organic acids in mango juice.[Method ] Six strains of L.plantarum were selected for fermentation of the juice samples from two mango varieties ‘Tainong' and ‘Guiqi'.The mass concentrations of organic acids and flavonoids in the juice samples were determined by ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS ).Orthogonal partial least squares discriminant analysis was employed to compare the metabolites in the mango juice samples fermented with different strains.[Result ] L.plantarum fermentation significantly enhanced the total antioxidant capacity (T-AOC ) …

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Effects Of Palmitic Acid-Rich Diet On Tumor Growth And Epithelial-Mesenchymal Transition In The Mouse Model Of Prostate Cancer, Jiayao Chen, Fengjiao Huang, Bingqian Sun, Yongquan Chen, Xiaoying Wang May 2025

Effects Of Palmitic Acid-Rich Diet On Tumor Growth And Epithelial-Mesenchymal Transition In The Mouse Model Of Prostate Cancer, Jiayao Chen, Fengjiao Huang, Bingqian Sun, Yongquan Chen, Xiaoying Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the effect of palmitic acid (PA)-rich diet on prostate cancer (PCa) in mice.[Method ] The TCGA database and immunohistochemistry (IHC) were used to analyze the differential expression of fatty acid synthase (FASN ) between the PCa tissue and adjacent normal tissue.In addition,twelve nude mice were subcutaneously implanted with LNCaP cells and assigned into two groups.One group was fed a PA-rich diet,while the other group was fed a normal control (NC) diet.Twelve mice overexpressing the C-myc gene (C-mycT) were assigned into two groups and fed the same diets as the nude mice.The growth of …

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Metagenomic Analysis Of Microbial Community Structure And Functional Genes In Horse Milk From Northern Xinjiang, Gaoshaer Kayierhali, Zhiang Fu, Danhua Ouyang, Haini Bayinda, Bakhetgul Manatbay May 2025

Metagenomic Analysis Of Microbial Community Structure And Functional Genes In Horse Milk From Northern Xinjiang, Gaoshaer Kayierhali, Zhiang Fu, Danhua Ouyang, Haini Bayinda, Bakhetgul Manatbay

Journal of Food Science and Biotechnology

[Objective ] Horse milk has a high nutritional value and a unique flavor,which are closely related to its complex microbial composition,and different geographical locations and climates will affect the microbial community structure of horse milk.This study aims to explore the effects of different geographical locations on the microbial community structure in horse milk.[Method ] Metagenomic technology was employed to analyze the microbial diversity of 14 batches of horse milk samples from 3 different regions in northern Xinjiang,and the functional genes were excavated.[Result ] A total of 26 species of microorganisms were identified,belonging to 9 phyla,14 classes,25 orders,28 families,and 45 genera.The …

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Effects Of Thermal Treatment On The Binding Ability Of Type I Collagen Toaroma Compounds Of Broth, Xiaolin Luo, Yi Yuan, Xiangyi Chen, Shutao Liu May 2025

Effects Of Thermal Treatment On The Binding Ability Of Type I Collagen Toaroma Compounds Of Broth, Xiaolin Luo, Yi Yuan, Xiangyi Chen, Shutao Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to reveal the interactions between collagen and volatile compounds during the cooking process.[Method ] The relative molecular weight,particle size,solubility,secondary structure,and surface hydrophobicity of collagen and the droplet size of the collagen emulsion were studied.Furthermore,the binding ability of collagen to volatile compounds of the aqueous and emulsion systems of collagen was measured.[Result ] As the heating time was extended,the triple-helix structure of collagen was destroyed and the polypeptide chains were degraded,which were accompanied with the decrease in surface hydrophobicity,increase in solubility,and heat-induced aggregation.The binding ability of collagen to volatile compounds gradually decreased with the extension of …

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Molecular Crosstalk Of Transcription Factors And Hormones In Drought Tolerance Genes In Plants, Cengi̇z Kaya May 2025

Molecular Crosstalk Of Transcription Factors And Hormones In Drought Tolerance Genes In Plants, Cengi̇z Kaya

Turkish Journal of Botany

Water deficit is a critical challenge to global agricultural productivity and food security, which is exacerbated by climate change and increasing water scarcity. To withstand drought stress, plants employ a variety of molecular strategies driven by complex regulatory networks. This review examines the central role of transcription factors (TFs) as master regulators that activate drought responsive genes, which in turn mediate key adaptive processes such as osmoregulation, antioxidative defense, and membrane stability. A distinctive aspect of this review is its focus on the dynamic interplay between TFs and hormonal signaling pathways, including abscisic acid, ethylene, salicylic acid, and jasmonic acid. …

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Parents Perceived First Aid Skills In Dealing With The Ingested Poisoning Products, Saudi Arabia, A Cross-Sectional Study, Maher Hassan Nahari, Bsaim Abdulsalam Altirkistani, Athoub Nasser Kadasa, Saleh Salah Alilwani Et.Al. May 2025

Parents Perceived First Aid Skills In Dealing With The Ingested Poisoning Products, Saudi Arabia, A Cross-Sectional Study, Maher Hassan Nahari, Bsaim Abdulsalam Altirkistani, Athoub Nasser Kadasa, Saleh Salah Alilwani Et.Al.

Saudi Toxicology Journal

Introduction: Toxins are substances that can lead to harmful effects when introduced to the body. Accidental poisonings remain a critical concern for pediatric health, so understanding the nature of toxins and the potential risks associated with them is a fundamental aspect of child safety. Parents' knowledge and attitudes towards toxins and poisoning incidents significantly influence the outcomes of accidental exposures. Materials and Methods: An observational cross-sectional study conducted across various regions of Saudi Arabia in March 2024. Participants were selected by convenience sampling. A total of 1,997 participants took the self-administered questionnaire. Results: The majority of the participants are married …

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Natural Microbial Consortium Construction Strategy From Rhizospheric Agricultural Soils To Improve Wheat (Triticum Durum Desf.) Seedling Growth, Ni̇da Arslan, Mi̇ne Gül Şeker, Özlem Akkaya, Yelda Özden Çi̇ftçi̇ May 2025

Natural Microbial Consortium Construction Strategy From Rhizospheric Agricultural Soils To Improve Wheat (Triticum Durum Desf.) Seedling Growth, Ni̇da Arslan, Mi̇ne Gül Şeker, Özlem Akkaya, Yelda Özden Çi̇ftçi̇

Turkish Journal of Botany

Microbial consortia of compatible microorganisms play a key role in enhancing agricultural sustainability by optimizing nutrient uptake by promoting plant growth more effectively. This study aimed to identify local isolates with the most effective plant growth-promoting (PGP) properties and to form a consortium of isolates showing the optimal synergistic effect between plant and bacterial components to improve the growth of wheat plants. For this purpose, 48 isolates identified from 145 isolates were screened for their PGP activities. According to the results, 16S rRNA gene sequencing was performed to identify the six isolates exhibiting the most promising activity. Different consortium groups …

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Taxonomic Revision Of Korean Salix Section Subviminales Based On Comparative Morphology And Complete Plastome Analysis, Young Moon Kim, Shukherdorj Baasanmunkh, Nudkhuu Nyamgerel, Won Seok Lee, Dong Chan Son, In Kyu Park, Bom Bi Jin, Hyo Sig Won, Hyeok Jae Choi May 2025

Taxonomic Revision Of Korean Salix Section Subviminales Based On Comparative Morphology And Complete Plastome Analysis, Young Moon Kim, Shukherdorj Baasanmunkh, Nudkhuu Nyamgerel, Won Seok Lee, Dong Chan Son, In Kyu Park, Bom Bi Jin, Hyo Sig Won, Hyeok Jae Choi

Turkish Journal of Botany

Salix section Subviminales, including only three species, is endemic to East Asia. In this study, we revised three species, S. gracilistyla, S. graciliglans, and S. blinii in Korea based on their plastomes and extensive morphological analyses to provide a comprehensive understanding of their taxonomic relationships. Based on our findings, we identified the morphological characteristics of S. blinii endemic to Korea, including its small size and distinct leaf shapes, which are well distinguished from both S. gracilistyla and S. graciliglans. Most of the morphological characteristics of S. gracilistyla and S. graciliglans overlapped, particularly leaf shape, floral structure, and growth habits. Next, …

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A New Species From Türkiye: Erigeron Akaydinii (Asteraceae), Batikan Günal, Gürkan Semi̇z, Sultan Akyol May 2025

A New Species From Türkiye: Erigeron Akaydinii (Asteraceae), Batikan Günal, Gürkan Semi̇z, Sultan Akyol

Turkish Journal of Botany

Erigeron akaydinii Günal & Semiz sp. nov., belonging to the Trimorpha Cass. (DC) section (Asteraceae), is described as a new species from Uludağ Mountain (Bursa, Türkiye). This study examines the diagnostic traits of E. akaydinii and related species, including morphological, palynological, and molecular analyses. Notes on the ecology, distribution, and conservation status of the new species are also provided, along with a diagnostic key for relevant taxa.

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Ecological Assessment Of Lentic Ecosystems In Ceyhan River Basin Using Phytoplankton Indices, Abuzer Çelekli̇, Emi̇ne Yonca Gümüş, Tolga Çeti̇n May 2025

Ecological Assessment Of Lentic Ecosystems In Ceyhan River Basin Using Phytoplankton Indices, Abuzer Çelekli̇, Emi̇ne Yonca Gümüş, Tolga Çeti̇n

Turkish Journal of Botany

Increasing exploitation of water resources has led to declining water quality in aquatic environments. Freshwater ecosystems face various environmental pressures, such as the impacts of climate change and intensifying land-use practices. This study aimed to assess the ecological preferences of phytoplankton communities and determine the ecological status (ES) of several reservoirs and lakes in Ceyhan River Basin across different seasons. A canonical correspondence analysis was conducted to understand the associations between phytoplankton assemblages and stressors in freshwater ecosystems, revealing a strong correlation of 97%. The factors that most influenced the distribution of phytoplankton species were electrical conductivity (EC), temperature, total …

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Effects Of Cytochalasin D On Motor Function In Drosophila, Airyel Noguera May 2025

Effects Of Cytochalasin D On Motor Function In Drosophila, Airyel Noguera

Honors Theses

Actin proteins play an important role in microfilaments, one of the three components of the cytoskeleton of the cell. The actin protein is responsible for cellular functions such as with their role in neuromuscular junctions. The dynamics of these proteins can be further explored with manipulation of polymerization through the treatment of a biochemical drug, Cytochalasin D. This fungal toxin caps the ends of actin filaments, destabilizing them by inhibiting G- and F-actin monomers from binding. Treating Drosophila in their early embryonic stage with this drug after permeabilization can give insights on the importance of actin proteins at neuromuscular junctions …

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Sickle Cell Mice Exhibit Elevated Plasma Bilirubin And Altered Intracranial Cerebral Blood Velocities That Are Exacerbated By Hypoxia-Reoxygenation, Francisco J. Nunez, Ashraf M. Mohieldin, Amy Y. Pan, Sean P. Palecek, Rahima Zennadi, Ramani Ramchandran, Kevin R. Rarick, Surya M. Nauli May 2025

Sickle Cell Mice Exhibit Elevated Plasma Bilirubin And Altered Intracranial Cerebral Blood Velocities That Are Exacerbated By Hypoxia-Reoxygenation, Francisco J. Nunez, Ashraf M. Mohieldin, Amy Y. Pan, Sean P. Palecek, Rahima Zennadi, Ramani Ramchandran, Kevin R. Rarick, Surya M. Nauli

Pharmacy Faculty Articles and Research

Sickle cell disease (SCD) is a genetic disorder characterized by sickle red blood cells (RBCs). Sickle RBCs cause cerebral vasculopathies including vaso-occlusive events, leading to ischemia-reperfusion injury and hypoxic tissue environment. To date, the physiological blood flow velocities in cerebral vessels of preclinical SCD models has not been evaluated under hypoxic-reoxygenation. In our study, we used transcranial ultrasound techniques to measure abnormal blood flow velocities in the internal carotid (ICA) and middle cerebral arteries (MCA) of transgenic sickle cell mice (SS) challenged with hypoxia-reoxygenation. Our study showed that SS mice that underwent hypoxic stress exhibited lower relative mean velocities in …

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Turtle Creek Tree Restoration Project, Rebecca Beneroff, Risa Kanefsky, Max Dicerbo, Pj Newhart, Amanda Mitchell May 2025

Turtle Creek Tree Restoration Project, Rebecca Beneroff, Risa Kanefsky, Max Dicerbo, Pj Newhart, Amanda Mitchell

Final Reports in ENST 411: Environmental Community Projects

Over the course of this project our group members Rebecca, Max, PJ, Amanda, and Risa worked closely with Jim Knight and Brian Auman from Turtle Creek Park to help research, plan, and execute a tree transplanting event that would be efficiently implemented and environmentally sound. This work involved extensive preparatory work in the park including soil testing, bare leaf tree identification, tree and shrub species characterization, and recommendation. The entire process was rooted in the most up to date literature and scientific practices surrounding bare root tree nurseries, existing land management plans, invasive species and public park management, ecological succession, …

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Mechanisms That Contribute To Age-Dependent Segregation Errors In Drosophila Oocytes, Zihan Meng May 2025

Mechanisms That Contribute To Age-Dependent Segregation Errors In Drosophila Oocytes, Zihan Meng

Dartmouth College Ph.D Dissertations

Meiotic chromosome segregation errors in human oocytes are the leading cause of miscarriages and aneuploid pregnancies, and these errors increase dramatically as women age. Using Drosophila oocytes as a model system, this dissertation identifies the NAD⁺-dependent deacetylase Sirt1 as a key regulator of chromosome segregation and meiotic arm cohesion. Loss of Sirt1 activity during meiotic prophase leads to premature loss of arm cohesion and increased segregation errors in Drosophila oocytes. In addition, elevated acetylation of its substrate, histone H4K16, indicates that Sirt1 activity declines in oocytes during aging. Strikingly, dietary administration of the Sirt1 activator SRT1720 preserves Sirt1 deacetylase activity …

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The Roles Of Oprf In Pseudomonas Aeruginosa Biofilms, Erin K. Cassin May 2025

The Roles Of Oprf In Pseudomonas Aeruginosa Biofilms, Erin K. Cassin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many bacteria form multicellular communities known as biofilms. Biofilms contain bacterial cells and a protective extracellular biofilm matrix. This matrix contains exopolysaccharides, extracellular DNA (eDNA), membrane vesicles, and proteins. The matrix proteins are far less characterized than other extracellular biofilm components. In biofilms formed by the model organism Pseudomonas aeruginosa, the protein OprF is abundant in the cellular outer membrane and the extracellular matrix. In my dissertation research, I have presented data supporting the hypothesis that the OprF protein significantly affects P. aeruginosa biofilms. By examining various strain backgrounds and the nutrient-dependent effects of glucose and sodium chloride, I demonstrate …

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The Effects Of Blood Flow Restriction And Body Weight Support Treadmill Walking On Electromyographic Activity In Lower Limb Muscles, Cyanea Davies May 2025

The Effects Of Blood Flow Restriction And Body Weight Support Treadmill Walking On Electromyographic Activity In Lower Limb Muscles, Cyanea Davies

UNLV Theses, Dissertations, Professional Papers, and Capstones

Blood flow restriction (BFR) is an emerging rehabilitation modality shown to enhance muscle activation and elicit strength gains comparable to high-intensity training at lower loads (Cognetti et al.,2019). Body weight support (BWS) treadmill walking is another modality that has gained popularity due to the effect it has on lowering muscle activation with increasing support levels (Jensen et al.,2016). However, to date no research has looked at electromyographic (EMG) activity utilizing both modalities concurrently. This study investigated if stride frequency (SF) and muscle activity of the rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA) and gastrocnemius (GA) would be influenced …

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Oral Prevalence Of Selenomonas Noxia Differs Among Orthodontic Patients Compared To Non-Orthodontic Controls: A Retrospective Biorepository Analysis, Kyle Hodges May 2025

Oral Prevalence Of Selenomonas Noxia Differs Among Orthodontic Patients Compared To Non-Orthodontic Controls: A Retrospective Biorepository Analysis, Kyle Hodges

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: The introduction of fixed orthodontic brackets in orthodontic therapy has the potential to significantly alter the oral microbial flora. Most orthodontic research has focused on cariogenic pathogens, while some evidence has demonstrated an increase in many known periodontal pathogens. However, little is known about the prevalence of the gram-negative periodontal pathogen, Selenomonas noxia (SN) among these patients.Methods: Using an existing saliva biorepository, n=208 samples from adult and pediatric orthodontic and non-orthodontic patients were identified and screened for the presence of SN using qPCR and validated primers. Results: In the pediatric study sample (n=89) 36% tested positive for the presence …

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Identifying Alternatively Spliced Events And Exons Between Blood Cell Types, Jessica Holder May 2025

Identifying Alternatively Spliced Events And Exons Between Blood Cell Types, Jessica Holder

UNLV Theses, Dissertations, Professional Papers, and Capstones

Transcript isoforms arising from alternative splicing events can contribute to the development of a cell’s identity and function and overall protein diversity. Peripheral blood is a useful model to study and evaluate computational methods for alternative splicing detection due to its abundant data across various sequencing protocols. The alternative splicing events across different blood cell types have not been completely identified and detecting alternative splicing through short read sequencing is still a challenging problem. Here, we propose to integrate multiple bulk RNA-seq datasets of purified blood cells using a novel integration method to identify the cell-type specific alternative splicing events …

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Dysregulation Of Vitamin D Receptor And Cyp450 Metabolism Enzymes May Explain Oral Cancer Responsiveness, Dustin Hunsaker May 2025

Dysregulation Of Vitamin D Receptor And Cyp450 Metabolism Enzymes May Explain Oral Cancer Responsiveness, Dustin Hunsaker

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many health benefits are associated with Vitamin D (VitD), although deficiency is associated with poor health outcomes and increased risk for cancer development. For example, many tissue specific enzymes are involved in VitD metabolism, and mutations or deletions within Vitamin D receptor (VDR) genes are known to increase cancer risk by altering their functions or bioavailability, although less is known about these phenomena in oral cancers. Using well characterized, commercially available oral cell lines (OKF4, HGF-1, SCC4, SCC9, SCC15, SCC25, CAL27), mRNA expression of P450 cytochrome VitD metabolic enzymes and receptor genes by qPCR revealed differential results. One oral cancer …

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Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz May 2025

Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer’s disease (AD) is an irreversible and devastating neurodegenerative disease characterized by progressive synaptic, dendritic, glial, and neuronal loss, collectively leading to impairments in learning, memory, and deterioration of cognitive and behavioral functions. AD is the most common form of dementia accounting for 60-80% of all cases. AD affects approximately 7 million Americans and is the 6th leading cause of death in the US. Furthermore, by 2050, the US is projected to spend over $1.1 trillion on AD-related treatments. Pathological hallmarks of AD include beta-amyloid (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), and chronic neuroinflammation, which can promote and exacerbate both …

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Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr May 2025

Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fungal exposure can cause acute and chronic illnesses or exacerbate existing illnesses. Some fungi are opportunistic pathogens and can lead to serious systemic fungal infections. In 2020, more than 150 million cases of severe fungal infections were reported globally resulting in an estimated 1.7 million deaths. Coccidioidomycosis, or Valley fever, is classified as a serious fungal infection caused by the fungi Coccidioides immitis and C. posadasii. These particular fungi are prevalent in the soil of the Southwestern United States, including Las Vegas, Nevada. In 2024, there were a total of 269 cases of Valley fever reported in Nevada, and …

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Torque Efficacy Of Cadmus Bracket Design Using Clear Aligners, Joseph Soderberg May 2025

Torque Efficacy Of Cadmus Bracket Design Using Clear Aligners, Joseph Soderberg

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Clear aligner therapy (CAT) is an alternative option for clinicians to use for orthodontic treatment as opposed to fixed appliances. Many patients prefer clear aligner therapy due to its esthetic looks, removability, ease of oral hygiene, and comfort. Clear aligner companies boast to clinicians that it can be used more efficiently and effectively than fixed appliances in many orthodontic cases. Although these claims have been made, there is a lack of evidence to prove that clear aligner therapy is more efficient or effective. This research will focus on torque control. This project is designed around a new, pre-manufactured attachment …

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Genome-Wide Association Of Gene Regions Controlling Selenium And Magnesium Accumulation In Walnuts (Juglans Regia L.), İrem Büyükalgan, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş May 2025

Genome-Wide Association Of Gene Regions Controlling Selenium And Magnesium Accumulation In Walnuts (Juglans Regia L.), İrem Büyükalgan, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş

Turkish Journal of Botany

Walnut (Juglans regia L.) is one of the most economically important species. It is of great importance to the food industry due to its nutritional value, and high content of many beneficial components such as macro and microelements. In the current study, the aim was to determine markers of single nucleotide polymorphism (SNP) associated with the gene(s) controlling the accumulation of Selenium (Se) and Magnesium (Mg) in walnuts. Se and Mg concentrations were measured in 154 genotypes of Juglans regia in 2021 and 2022. A total of 16,473 SNP markers were used for association mapping to analyze the marker-trait associations. …

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A New Coralloid Arecoid Palm Root Mat From The Deccan Intertrappean Beds Of India And Its Significance, Sanchita Kumar, Robert Spicer, Mahasin Ali Khan May 2025

A New Coralloid Arecoid Palm Root Mat From The Deccan Intertrappean Beds Of India And Its Significance, Sanchita Kumar, Robert Spicer, Mahasin Ali Khan

Turkish Journal of Botany

A new fossil-species of coralloid palm root mat under the organ genus Rhizopalmoxylon is reported from the latest Maastrichtian (Late Cretaceous) to earliest Danian (Early Palaeocene) sediments (c. 66–65Ma) of the Deccan Intertrappean Beds of Madhya Pradesh, Central India. The significant anatomical attributes, specifically an exodermis comprising 2–4 layered parenchymatous cells; a 5–8 layered homogeneous outer cortex, a highly lacunate inner cortex central diffuse layer of aerenchyma with well-developed radially elongated cells arranged in 2–4 rows, and a stele consisting of radial and exarch vascular bundles with proto and metaxylem strands reveal its close resemblance to root mats of extant …

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