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Nitrogen Transport Patterns And Vegetation Community Optimization In Urban Green Space Soils Using Multifactor Coupling Analysis, Shujian Yang, Baoxi Yu, Zheng He, Baochang Liu, Chang Liu Apr 2026

Nitrogen Transport Patterns And Vegetation Community Optimization In Urban Green Space Soils Using Multifactor Coupling Analysis, Shujian Yang, Baoxi Yu, Zheng He, Baochang Liu, Chang Liu

Turkish Journal of Agriculture and Forestry

As vital components of urban ecosystems, urban green spaces directly affect soil fertility and plant growth through nitrogen transport dynamics. This study addresses the existing methodological gaps in understanding nitrogen cycling within urban green spaces, particularly the unclear interaction mechanisms between vegetation structure and soil physicochemical characteristics. The study was conducted in the Green Expo Park located in Nanjing, China. Using a stratified sampling approach, physicochemical indicators of soil layers were measured and combined with community parameters—including leaf area index, vegetation coverage, and plant density—to identify key drivers through correlation and multiple regression analyses. The regulatory mechanisms of soil physicochemical …


Mitigation Of Salinity Stress In Carnation Plants Through Zinc Oxide Nanoparticles: Growth, Physiological, And Biochemical Responses, Adel A. Rezk, Ishtiaq Ahmad, Maryam, Muhammad Saleem, Othman Al-Dossary, Hossam S. El-Beltagi, Mohammed Aldaej, Bader Y. Alsubaie, Hati̇ce Gülen, Tarek Shalaby, Riaz Ahmad Apr 2026

Mitigation Of Salinity Stress In Carnation Plants Through Zinc Oxide Nanoparticles: Growth, Physiological, And Biochemical Responses, Adel A. Rezk, Ishtiaq Ahmad, Maryam, Muhammad Saleem, Othman Al-Dossary, Hossam S. El-Beltagi, Mohammed Aldaej, Bader Y. Alsubaie, Hati̇ce Gülen, Tarek Shalaby, Riaz Ahmad

Turkish Journal of Agriculture and Forestry

Carnation (Dianthus caryophyllus L.) growth and floral yield are severely reduced when grown in soils with excessive salinity. Mitigation of adverse effects from salinity-induced stress is necessary for sustainable carnation cultivation. Although various approaches have been developed, the use of zinc oxide nanoparticles (ZnO-NPs) to ameliorate these effects remains scarcely explored. The current study explored the potential of ZnO-NPs to alleviate salinity-induced stress by examining their effects on morphophysiological and biochemical traits. A controlled pot experiment was conducted using a factorial design with three concentrations of sodium chloride (0, 50, and 100 mM) and three of ZnO-NPs (0, 50, and …


Silicon-Mediated Enhancement Of Wheat Tolerance To Drought Stress: A Comparative Study Of Antioxidant Activity, Photosynthesis, Secondary Metabolites, And Yield, Abida Kausar, Rida Yasmeen, Shahid Iqbal, Muhammad Bilal Hafeez, Asif Mukhtiar, Sadia Azeem, Ali Raza, Samreen Nazeer, Muhammad Zubair Akram, Muhammad Kamran, Fahd Rasul, Noreen Zahra Apr 2026

Silicon-Mediated Enhancement Of Wheat Tolerance To Drought Stress: A Comparative Study Of Antioxidant Activity, Photosynthesis, Secondary Metabolites, And Yield, Abida Kausar, Rida Yasmeen, Shahid Iqbal, Muhammad Bilal Hafeez, Asif Mukhtiar, Sadia Azeem, Ali Raza, Samreen Nazeer, Muhammad Zubair Akram, Muhammad Kamran, Fahd Rasul, Noreen Zahra

Turkish Journal of Agriculture and Forestry

Drought stress (DS) is a major constraint on optimal plant growth and yield. Agricultural researchers have been actively exploring fertilizers that can enhance crop production under DS conditions. Silicon (Si) application has emerged as a promising strategy for managing DS in various crops. This study investigated the potential of Si soil drenching to mitigate the adverse effects of varying levels of DS (at 100%, 70%, and 40% field capacity) in wheat. Two varieties (Ujala-2016 and FSD-2008) were used to evaluate the influence of Si (2.5 mM) on antioxidant activity, oxidative burst, secondary metabolites, growth, and yield. The results indicated that …


Long-Term Tillage And Straw Returning Practices Enhance Soil Humus Composition, Carbon Sequestration, And Ecological–Economic Benefits, Kai Wang Apr 2026

Long-Term Tillage And Straw Returning Practices Enhance Soil Humus Composition, Carbon Sequestration, And Ecological–Economic Benefits, Kai Wang

Turkish Journal of Agriculture and Forestry

While straw return is widely promoted, its specific effects on soil humus composition, structure, and ecological functions are not fully understood. This study investigates the long-term impacts of different straw types and farming practices on humus composition, carbon sequestration, and ecological–economic benefits. In Hunan Province’s paddy fields, six soils with 5–30-year farming histories were selected. Treatments included a blank control, corn straw return, and rice straw return, each replicated three times. Humus structure was analyzed via infrared spectroscopy, component contents were determined by alkali extraction, and a carbon footprint model assessed emissions. Ecological economic analysis integrated soil carbon pool dynamics, …


Optimizing Itpa R178c Assays Via Hplc, Jared J. Reisnouer, Wally D. Pines Apr 2026

Optimizing Itpa R178c Assays Via Hplc, Jared J. Reisnouer, Wally D. Pines

2026 Symposium

Two of the major nucleotide bases in DNA and RNA (Adenine and Guanine) are derived from the purine Inosine Monophosphate (IMP). IMP may occasionally form the noncanonical nucleotide Inosine Triphosphate (ITP) within the cell and become incorporated into DNA during replication, leading to potentially lethal errors. To combat this, human cells produce the “housekeeping” enzyme Inosine Triphosphatase (ITPA) to revert ITP to IMP. A mutation of this protein that replaces the 178th amino acid Arginine with Cysteine (R178C) is associated with a fatal infantile encephalopathy. Previous assessments of enzyme-substrate binding and catalysis for ITPA variants have been run at a …


New Ways To Address The Plastic Problem, Andrew J. Hanna Apr 2026

New Ways To Address The Plastic Problem, Andrew J. Hanna

The Penguin Review

Since 1950, the world has produced some 9.2 billion metric tonnes of plastic.1 Other sources place the total closer to ten billion metric tonnes Furthermore, nearly 500 million tonnes of new plastic are manufactured each year– a figure that's projected to increase to 1.2 billion tonnes by 2060.2 The environmental effects of all this plastic production and pollution are disturbing. Because most plastics are synthetic–meaning they contain "no molecules found in nature"– they can't decompose. Instead, they just break down into smaller and smaller pieces, becoming microplastics (less than five millimeters (5 million nanometers) across) and then nanoplastics (less than …


Assessment Of Total Cellular Protein Following Fatty Acid Treatment Using The Bca Assay, Carli B. Maguire Apr 2026

Assessment Of Total Cellular Protein Following Fatty Acid Treatment Using The Bca Assay, Carli B. Maguire

Create@State

Fatty acids can influence cellular metabolism and protein homeostasis, potentially altering total protein content within cell samples. Accurate quantification of total protein concentration is essential for standardization for further biochemical assays and ensuring reproducibility. In this study, adherent mammalian cells were treated with a defined fatty acid preparation under controlled culture conditions. Following treatment, whole-cell lysates were collected and total protein concentration was determined using the bicinchoninic acid (BCA) assay. The BCA assay is a colorimetric method based on the reduction of Cu²⁺ to Cu¹⁺ by peptide bonds under basic conditions, followed by formation of a purple-colored complex between bicinchoninic …


Skin Pattern As A Potential Monitoring Tool For Frog Populations, Lídize Sagarnaga Rivera, Virginie Rolland Dr., Lorin Neuman-Lee Dr. Apr 2026

Skin Pattern As A Potential Monitoring Tool For Frog Populations, Lídize Sagarnaga Rivera, Virginie Rolland Dr., Lorin Neuman-Lee Dr.

Create@State

Skin pattern as a potential monitoring tool for frog populations

Population monitoring, which requires identifying individuals, is crucial for species conservation. Common techniques involve marking, which can harm animals and alter their behaviors. Natural markings are an alternative not yet explored for amphibians. Yet, the traditional method with elastomers (fluorescent implants) is invasive and not completely reliable—the tag may become lost or hard to see. The American green tree frog (Dryophytes cinereus) possesses naturally occurring and distinct golden dots on their dorsal side.  Therefore, we aim to assess whether patterns of golden dots on the skin of green …


Amyloid Beta-42 Neurotoxicity In Drosophila Retinal Development, Shay O. Sims, Pierce Duncan, Malachi Abon, Jacob G. Smith Apr 2026

Amyloid Beta-42 Neurotoxicity In Drosophila Retinal Development, Shay O. Sims, Pierce Duncan, Malachi Abon, Jacob G. Smith

Create@State

Alzheimer's disease (AD) represents one of the most prevalent neurodegenerative disorders globally. Thus far, the underlying mechanisms associated with the pathogenesis of AD are innately elusive. Two hallmarks associated with the progression of AD exist, including Amyloid-Beta 42 (Aβ42) protein plaque formation and hyperphosphorylation of tau proteins in neurons. Amyloid-beta is known to concentrate with other neuronal proteins as complexes form, including the cytoskeletal protein actin. However, whether actin contributes to neuronal decline in AD is unknown. To further understand the cellular cascades associated with AD, we investigated the role of cytoskeleton dynamics in modulating oxidative stress and neuroinflammation within …


Transgenic Plant Cells For The Cost-Effective Production Of Pharmaceutical Proteins, Maria Gambaro Apr 2026

Transgenic Plant Cells For The Cost-Effective Production Of Pharmaceutical Proteins, Maria Gambaro

Create@State

Plant-based systems are becoming an important method for producing pharmaceutical proteins because they can be more cost-effective, and safer compared to traditional production methods which commonly use mammalian cells. This project aims to develop a transgenic plant cell system that can produce a pharmaceutical protein using molecular cloning techniques. A transgenic plant cell has the DNA of another plant integrated into its genome, altering its gene expression to produce different proteins. To begin, a plasmid carrying the gene of interest and the DNA components needed for expression will be designed. The plasmid will then be used to introduce the gene …


Variation In Infection Prevalence Of Splendidofilaria Pectoralis Across Alaskan Grouse Populations, Anahi Garcia Valdez, Diego Martinez Apr 2026

Variation In Infection Prevalence Of Splendidofilaria Pectoralis Across Alaskan Grouse Populations, Anahi Garcia Valdez, Diego Martinez

Create@State

In recent years, rapid climate change has altered species distributions worldwide and influenced parasite transmission dynamics in wildlife systems. Parasite infections play an important role in shaping patterns of disease distribution across species and populations. Understanding variation in infection prevalence across geographic regions and host demographic groups is essential for interpreting these patterns. Splendidofilaria pectoralis is a filarial nematode that infects the connective tissues of grouse (Aves: Tetraonini) in Alaska and has been moving northward as the climate warms. However, relatively little is known about the variation in prevalence of the nematode across geography and demography. This project examines variation …


Inc3vits Model: A Hybrid Architecture To Accelerate And Reduce Complexity For The Deepvariant Model For Variant Calling, Mustafa Al-Saffar, Sura Z. Al Rashid Apr 2026

Inc3vits Model: A Hybrid Architecture To Accelerate And Reduce Complexity For The Deepvariant Model For Variant Calling, Mustafa Al-Saffar, Sura Z. Al Rashid

Karbala International Journal of Modern Science

Deep learning has revolutionized genomic variant calling, yet the computational cost of current systems continues to limit scalability. We present a controlled efficiency study of DeepVariant-style pileup architectures under identical training and inference conditions, comparing architectural downsizing with a hybrid CNN–local attention design. Inc3ViTs pairs a streamlined InceptionV3 stem with a lightweight local attention head based on patch tokenization and windowed self-attention, enabling a direct comparison with a CNN-only reduced Inception baseline. Across whole-genome and whole-exome short-read datasets, Inc3ViTs reduces training time by ~40–50% and reduces inference runtime relative to the original DeepVariant. The CNN-only baseline indicates that most speedups …


Infertility And Mental Health, Laynie Pugmire Apr 2026

Infertility And Mental Health, Laynie Pugmire

Family Perspectives

No abstract provided.


Impacts Of Adoption On Attachment, Laynie Pugmire Apr 2026

Impacts Of Adoption On Attachment, Laynie Pugmire

Family Perspectives

No abstract provided.


Swosu Research And Scholarly Activity Fair 2026, Swosu Office Of Sponsored Programs Apr 2026

Swosu Research And Scholarly Activity Fair 2026, Swosu Office Of Sponsored Programs

SWOSU Research and Scholarly Activity Fair Programs

On behalf of the University Research and Scholarly Activity Committee (URSAC) and the Office of Sponsored Programs (OSP) at Southwestern Oklahoma State University, we are pleased to welcome you to the Thirty-Fourth SWOSU Research and Scholarly Activity Fair.


Elasmobranchii Oral Microbiome Diversity Within Southeast Florida: Implications Of Shark Zoonotic And Antibiotic Resistant Pathogens Associated With Human Interactions, Amanda Finnefrock Apr 2026

Elasmobranchii Oral Microbiome Diversity Within Southeast Florida: Implications Of Shark Zoonotic And Antibiotic Resistant Pathogens Associated With Human Interactions, Amanda Finnefrock

All HCAS Student Capstones, Theses, and Dissertations

Sharks are incredibly common in the Atlantic and Gulf waters surrounding Florida. Despite the prevalent nature of these animals, little research exists on the composition of their microbial communities (or “microbiomes”). Here we aim to determine the microbial makeup of the oral environment of sharks so that we can determine if there are any bacteria of clinical significance to humans, such as being antibiotic-resistant or having elevated capability for pathogenicity. A total of 41 samples were collected from the mouths and teeth of bull, Caribbean reef, great hammerhead, lemon, nurse, and sandbar sharks caught in Southeast Florida using sterile swabs …


Uptake And Fate Of Silver And Zinc Engineered Nanoparticles In Maize Under Single And Binary Dosing Soil Ecosystems, Lei Xu, Qingbo Yang, Xingmao Ma, Honglan Shi, John Yang, Hu Yang, Samira Mahdi, Ying Wang, Young Shin Jun Apr 2026

Uptake And Fate Of Silver And Zinc Engineered Nanoparticles In Maize Under Single And Binary Dosing Soil Ecosystems, Lei Xu, Qingbo Yang, Xingmao Ma, Honglan Shi, John Yang, Hu Yang, Samira Mahdi, Ying Wang, Young Shin Jun

Chemistry Faculty Research & Creative Works

Recent agricultural applications of engineered metallic nanoparticles (ENPs) have raised concerns about their uptake and fate in plants. To understand this critical issue, this study investigated the fate and uptake of silver (Ag) and zinc oxide (ZnO) ENPs in maize (Zea mays L.) after single or binary ENP exposure in soil. Results indicated that both Zn and Ag elemental concentrations in roots increased with increasing ENP dosage. Ag NPs in the tissues were detected, but not Zn NPs. Ag NP concentration was 3 times higher in the roots than in the shoots at low Ag NP dosing, while Ag NP …


Impact Of Climate Change On Agricultural Production In The North China Plain And Adaption Strategies, Yanjun Shen, Ying Guo, Chuanwei Zhang, Yaning Chen Apr 2026

Impact Of Climate Change On Agricultural Production In The North China Plain And Adaption Strategies, Yanjun Shen, Ying Guo, Chuanwei Zhang, Yaning Chen

Bulletin of Chinese Academy of Sciences (Chinese Version)

Over the past century, global warming has posed significant challenges to the North China Plain (NCP), a core region for grain production, where resource-induced water scarcity now coincides with complex meteorological disasters. In recent years, the NCP has exhibited new climatic characteristics, notably the transition from a “warm-dry” to a “warm-wet” pattern accompanied by asymmetric warming, leading to an increased frequency of extreme events such as droughts, abrupt dry-flood alternations, and temperature extremes. These shifts pose a grave threat to regional grain stability. Currently, critical gaps remain in the understanding of the underlying disaster mechanisms, as well as in predictive …


Accelerating Marine Science And Technology Innovation Under Great Power Competition: Challenges And Recommendations, Qingbin Guo, Yongsha Xiong, Shifang Sun Apr 2026

Accelerating Marine Science And Technology Innovation Under Great Power Competition: Challenges And Recommendations, Qingbin Guo, Yongsha Xiong, Shifang Sun

Bulletin of Chinese Academy of Sciences (Chinese Version)

Against the backdrop of intensifying great-power competition, the core issues of global technological competition and cooperation are increasingly converging on the marine domain. The oceans are progressively becoming a critical strategic sphere for national development and security. At present, China is steadily advancing towards its goal of becoming a maritime power, achieving historic leaps in technological innovation such as shipbuilding and deep-sea exploration. Nevertheless, the path ahead for China’s marine science and technology innovation will inevitably face severe international circumstances and competition from established global maritime powers. Based on a review of global and Chinese progress in marine science and …


Construction Of China’S Marine Protected Area System In 15th Five-Year Plan, Ke Duan, Danhong Chen, Keqiang Li, Limin Han, Zhengyan Liu, Dongliang Lu, Xiulin Wang Apr 2026

Construction Of China’S Marine Protected Area System In 15th Five-Year Plan, Ke Duan, Danhong Chen, Keqiang Li, Limin Han, Zhengyan Liu, Dongliang Lu, Xiulin Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The establishment of the marine protected area (MPA) system constitutes a critical component of the national initiative to comprehensively advance the development of a nature reserve system centered on national parks. This study explores on domestic and international development trends from aspects such as conservation strategies, international policies, high seas protection, and development trends. It also sorts out and analyzes the construction status of marine protected area systems in China and the United States. Centering on issues in China related to spatial layout, management systems, policies and laws, scientific research support, high seas governance, and land-sea management, the study puts …


The Impact Of State And Federal Policies On Academic Researchers: Findings From A National Survey, Dylan Ruediger, Chelsea Mccracken, Jonathan Barefield Apr 2026

The Impact Of State And Federal Policies On Academic Researchers: Findings From A National Survey, Dylan Ruediger, Chelsea Mccracken, Jonathan Barefield

Copyright, Fair Use, Scholarly Communication, etc.

Key findings

● State and federal policies targeting divisive concepts or DEI are shaping research agendas at scale and across disciplines. Twenty percent of all respondents, and 29 percent of researchers working in states with divisive concepts or similar laws, reported having avoided certain research topics because of state laws and policies.

● Eight percent of respondents representing a wide range of disciplines reported having had a federal grant cancelled in 2025.

● Eleven percent of respondents reported that federal and state policies restricting research activities are compelling them to seek employment out of state, to leave the academy, or …


Geographical And Anatomical Microbiome Variation In Invasive Green Iguanas (Iguana Iguana), Amanda A. Diaz Apr 2026

Geographical And Anatomical Microbiome Variation In Invasive Green Iguanas (Iguana Iguana), Amanda A. Diaz

All HCAS Student Capstones, Theses, and Dissertations

The common green iguana (Iguana iguana) was introduced to South Florida in 1965 and has since been an especially pernicious threat both environmentally and economically. This highly invasive species is also expanding in range and populations at an astonishing rate. Understanding how this reptile is able to adapt and thrive in novel environments is of imperative need in order to begin managing their disruptive populations. Notwithstanding their negative impacts and significance, the microbiome of wild populations has not yet been characterized. Here, using 16S ribosomal RNA gene sequencing, this study is the first to characterize the microbiome composition …


Prediction Of Antidiabetic Activity Of Swietenia Mahagoni Compounds Through Pparγ Activation: Machine Learning And Molecular Docking Analysis, Weri Veranita, Siti Nurbaya Apr 2026

Prediction Of Antidiabetic Activity Of Swietenia Mahagoni Compounds Through Pparγ Activation: Machine Learning And Molecular Docking Analysis, Weri Veranita, Siti Nurbaya

Indonesian Journal of Medical Chemistry and Bioinformatics

Type 2 diabetes mellitus is a chronic metabolic disorder requiring long-term therapy, yet current synthetic PPARγ agonists like thiazolidinediones are often associated with serious adverse effects. Therefore, identifying natural alternatives from sources such as Swietenia mahagoni is essential to provide effective therapy with potentially lower toxicity profiles. This study employed an in silico machine learning approach using SkelSpheres descriptors to predict the IC₅₀ values of compounds derived from the seeds of Swietenia mahagoni against PPARγ, followed by molecular docking validation using Molegro Virtual Docker (MVD). The predictive model for PPARγ agonists demonstrated acceptable validity (R²-test = 0.5308; accuracy = 84.01%). …


Impacts Of Climate Change On China’S Agricultural Production And Proposed Countermeasures, Yaning Chen, Yanjun Shen, Ming Jiang Apr 2026

Impacts Of Climate Change On China’S Agricultural Production And Proposed Countermeasures, Yaning Chen, Yanjun Shen, Ming Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Climate change is among the most severe global challenges today. It directly impacts agricultural production, which is highly dependent on climatic conditions, imposing multi-dimensional and systemic risks and challenges on China’s agriculture. Drawing on observational data and analysis of the literature, this study systematically examines the impacts of climate change on agricultural production in China. Over the past half century, China’s annual mean surface temperature has risen significantly at a rate of 0.31℃ per decade, exceeding the contemporaneous global average. This trend has intensified climatic variability and extremes, disrupted the prior balance of agricultural water resources, and led to the …


Impacts Of Climate Change On Agricultural Production And Adaptation Strategies In Northeast China, Ming Jiang, Aizhen Liang, Peng Qi Apr 2026

Impacts Of Climate Change On Agricultural Production And Adaptation Strategies In Northeast China, Ming Jiang, Aizhen Liang, Peng Qi

Bulletin of Chinese Academy of Sciences (Chinese Version)

As the “stabilizer” of national food security, Northeast China is highly sensitive to climate change. Over the past 60 years, the regional temperature has risen significantly at a rate of 0.034℃/a, which is much higher than the global average of 0.0074℃/a. The improvement of thermal resources has driven a significant northward expansion of high-yield and heat-demanding crops, such as maize and rice. Nevertheless, increased warming has enhanced evapotranspiration demand, which, combined with the expansion of planting scales, has led to a 19.8% increase in agricultural irrigation water consumption over the past 20 years, resulting in a prominent contradiction between supply …


Considerations For Microbial Inoculation Under Dryland Stress Conditions, Benedict Odinaka Okorie Apr 2026

Considerations For Microbial Inoculation Under Dryland Stress Conditions, Benedict Odinaka Okorie

Plants, Soils and Climate Student Research

Microbial inoculants are critical for sustainable crop production in dryland agriculture. However, several limitations (drought, heat, salinity, nutrient deficiency, etc.) of drylands and soil variability limit their consistent performance. Climate, soil properties (pH, texture, etc.), and their interactions are strong filters for microbial communities, functions, and activities across multiple scales, regions, and ecosystems. This review discusses several considerations of the peculiarities of drylands that must be factored into microbial formulations and inoculations decisions. Blanket/universal microbial formulations, inoculation methods, timings, and rates generally approach microbial, plant, and soil functions in isolation. This masks the complex microbial, soil, plant, environmental interactions, and …


Evaluating The Impact Of Residential Landscape Audits Using 5-Second Water Use Data, Mahmud Aveek, Camilo J. Bastidas Pacheco, David E. Rosenberg, Jeffery S. Horsburgh, Kelly Kopp, Belize A. Lane Apr 2026

Evaluating The Impact Of Residential Landscape Audits Using 5-Second Water Use Data, Mahmud Aveek, Camilo J. Bastidas Pacheco, David E. Rosenberg, Jeffery S. Horsburgh, Kelly Kopp, Belize A. Lane

Civil and Environmental Engineering Student Research

We used 5-s water use data to evaluate the effectiveness of residential landscape water audits in summer 2022. Fifty-nine households in two northern Utah cities were monitored for 2–5 weeks before and 3–10 weeks after an audit. We found that the distribution of weekly irrigation volumes postaudit was statistically less than the distribution preaudit (significant at the 1.9E10-5 level). Collectively, the participants reduced their landscape irrigation water use by approximately 379,000 L per week (100,300 gal per week; 0.3 acre-feet per week). We also analyzed changes in irrigation event volume, duration, frequency, and the number of days between events at …


Sex Differences In Proteomic Response To Ischemic Stroke, Christopher J. Mclouth, Hunter S. Hazelwood, Jacqueline A. Frank, Jordan P. Harp, David Dornbos Iii, Justin F. Fraser, Keith R. Pennypacker Apr 2026

Sex Differences In Proteomic Response To Ischemic Stroke, Christopher J. Mclouth, Hunter S. Hazelwood, Jacqueline A. Frank, Jordan P. Harp, David Dornbos Iii, Justin F. Fraser, Keith R. Pennypacker

University Faculty Publications and Creative Works

Background: Women often experience greater disability after ischemic stroke than men, but the biological mechanisms underlying these differences remain unclear. Proteomic analysis may identify sex-specific molecular pathways that contribute to stroke rehabilitation and recovery.

Methods: We analyzed plasma samples from 141 patients enrolled in the Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC). Expression of 184 inflammatory and cardiometabolic proteins, measured proximal and distal to the clot, was quantified using Olink panels. Associations between protein expression and discharge outcomes – including the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS), and Montreal Cognitive Assessment …


Hormetic Ethanol Effects On Fitness And Attraction In Irradiated Aedes Aegypti, Kayden Robey, Gabriel Borg, Immo Hansen Apr 2026

Hormetic Ethanol Effects On Fitness And Attraction In Irradiated Aedes Aegypti, Kayden Robey, Gabriel Borg, Immo Hansen

The Agora

Sterile insect technique (SIT) is an increasingly important strategy for controlling mosquito populations while reducing reliance on chemical insecticides and genetically modified organisms. A major limitation of SIT is the reduced fitness and competitiveness of irradiated male mosquitoes, which can compromise population suppression efforts. This study investigates whether hormetic ethanol exposure improves post-irradiation fitness in Aedes aegypti males, a primary vector of dengue, chikungunya, and yellow fever. Adult male mosquitoes were fed either a standard sugar solution or a sugar solution supplemented with 5% ethanol prior to irradiation. Males were sterilized using X-ray irradiation at 50 Gy and assessed for …


Maternal Inflammation Alters Nuclear And Mitochondrial Dna Methylation Patterns In Neonatal Brain Monocytes, Andrew Ebenezer, Jonathan Hicks, Brooke Hollander, Alexander Hone, Mona Batish, Robert Akins, Adam Marsh, Elizabeth Wright-Jin Apr 2026

Maternal Inflammation Alters Nuclear And Mitochondrial Dna Methylation Patterns In Neonatal Brain Monocytes, Andrew Ebenezer, Jonathan Hicks, Brooke Hollander, Alexander Hone, Mona Batish, Robert Akins, Adam Marsh, Elizabeth Wright-Jin

Department of Medicine Faculty Papers

Neonatal hypoxic ischemic encephalopathy (HIE) is a common birth complication that can cause death or lifelong disabling conditions like cerebral palsy, epilepsy, and autism. It is well established that maternal infection and inflammation are significant risk factors for HIE but reasons for this increase in neurological risk to the offspring remain unknown. Inflammation or infection are associated with epigenetic changes and may contribute to the increased risk of neurodevelopmental disability in exposed offspring. Here, we analyzed and compared DNA methylation patterns in brain monocytes isolated from control, maternal immune activation (MIA), and an inflammation sensitized HIE (IS-HIE) CF-1 mouse model …