Digital Commons Network^™

Xanthohumol As A Potential Therapeutic Strategy For Acute Myeloid Leukemia: Targeting The Flt3/Srpk1 Signaling Axis, Duan-Na Zhang, Wen-Ya Yang, Xiao-Xue Hu, Xiao-Min-Ting Song, Chuan-Jie Guo, Fu Peng, Yu-Zhi Li, Zhi-Xing Cao

Journal of Food and Drug Analysis

Xanthohumol (XN) is an isoprene chalcone found in hops (Humulus lupulus L.), a food ingredient with a wide range of pharmacological activities. The aim of this study was to reveal the therapeutic effect of XN on acute myeloid leukemia (AML) and the potential underlying molecular mechanism. Through network pharmacology analysis, molecular docking, and HTRF determination, XN was shown to inhibit the kinase activities of FLT3 and SRPK1 by targeting their ATP-binding domains, with IC₅₀ values of 1.51 ± 0.44 μM and 0.37 ± 0.15 μM, respectively. By inhibiting AML cell proliferation, promoting apoptosis, regulating autophagy, and inhibiting …

Within-Trial Cost-Effectiveness Of Novel Macrophage-Regulating Treatment On Wound Healing In Patients With Diabetic Foot Ulcers, Hsuan-Yu Su, Chen-Yi Yang, Yi-Hsin Chang, Shyi-Gen Chen, Jui-Ching Chen, Hui-Ju Ho, Huang-Tz Ou, Shihchen Kuo

Journal of Food and Drug Analysis

An M1/M2 macrophage-regulating treatment, ON101 cream, has shown its superior healing efficacy for diabetic foot ulcers (DFUs) versus standard absorbent dressing, according to a phase Ⅲ trial. Given its high cost, corroborating the economic value of ON101 treatment can facilitate clinical and policy decision-makings. This study sought to evaluate the cost-effectiveness of ON101 versus an absorbent dressing for patients with DFUs from Taiwan's healthcare sector perspective. This economic evaluation utilized effectiveness and cost data (in 2022 USD) from a randomized controlled trial of ON101, published literature, and Taiwan’s National Health Insurance program. Incremental cost-effectiveness ratio (ICER) against willingness-to-pay (WTP) threshold …

A Deep Dive Into The Orchard Of Health: Exploring The Anti-Cancer And Anti-Aging Potential Of Apple Polyphenols, Li-Ching Chen, Han-Sheng Chang, Yuan-Soon Ho

Journal of Food and Drug Analysis

Apples, a ubiquitous and beloved fruit, harbor a treasure trove of bioactive compounds, with apple polyphenols (APs) taking center stage. This review delves into the latest scientific advancements illuminating the anti-cancer and anti-aging properties of APs. We dissect the intricate mechanisms by which APs combat cancer initiation, progression, and metastasis, highlighting their prowess in inducing apoptosis, inhibiting angiogenesis, and modulating cell signaling pathways. Furthermore, we explore the multifaceted ways APs combat aging, including their potent antioxidant and anti-inflammatory actions, DNA protective effects, and ability to modulate cellular processes like autophagy and metabolism. This comprehensive review underscores the therapeutic promise of …

Functional Connectivity Of Red Chlorophylls In Cyanobacterial Photosystem I Revealed By Fluence-Dependent Transient Absorption, Sara Sohail, S. Sohoni, P.-C. Ting, L. R. Fantz, S. M. Abdulhadi, C. Macgregor-Chatwin, A. Hitchcock, C. N. Hunter, G. S. Engel, S. C. Massey

Chemistry & Biochemistry Faculty Works

External stressors modulate the oligomerization state of photosystem I (PSI) in cyanobacteria. The number of red chlorophylls (Chls), pigments lower in energy than the P₇₀₀ reaction center, depends on the oligomerization state of PSI. Here, we use ultrafast transient absorption spectroscopy to interrogate the effective connectivity of the red Chls in excitonic energy pathways in trimeric PSI in native thylakoid membranes of the model cyanobacterium Synechocystis sp. PCC 6803, including emergent dynamics, as red Chls increase in number and proximity. Fluence-dependent dynamics indicate singlet–singlet annihilation within energetically connected red Chl sites in the PSI antenna but not within bulk Chl …

Inflammasomes Primarily Restrict Cytosolic Salmonella Replication Within Human Macrophages, Marisa S. Egan, E. A. O'Rourke, S. Kumar Mageswaran, B. Zuo, I. Martynyuk, T. Demissie, E. N. Hunter, A. R. Bass, Y.-W. Chang, I. E. Brodsky, S. Shin

Biology Faculty Works

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that utilizes its type III secretion systems (T3SSs) to inject virulence factors into host cells and colonize the host. In turn, a subset of cytosolic immune receptors respond to T3SS ligands by forming multimeric signaling complexes called inflammasomes, which activate caspases that induce interleukin-1 (IL-1) family cytokine release and an inflammatory form of cell death called pyroptosis. Human macrophages mount a multifaceted inflammasome response to Salmonella infection that ultimately restricts intracellular bacterial replication. However, how inflammasomes restrict Salmonella replication remains unknown. We find that caspase-1 is essential for mediating inflammasome responses …

A Study To Identify The Causal Rare Genetic Variants In Primary Open And Closed Angle Glaucoma, Pseudoexfoliation Syndrome, And Associated Glaucoma, Suganya K

Theses and Dissertations

BACKGROUND: Glaucoma is the second most common cause of blindness globally typically diagnosed with a triad of clinical symptoms of increased intraocular pressure (IOP) with associated optic disc, optic nerve head (ONH) changes, and visual field defects. Genetic and environmental factors are some of the strong aetiology factors for glaucoma and identification of these factors has a potential implication in the management of the disease and its outcome. There is a paradigm shift towards understanding the genetics of glaucoma, wherein the variants in the nuclear, mitochondrial genome and other regulatory regions are being identified as contributing risk factors.

METHODOLOGY AND …

Induced Mutagenesis In West Nile Virus Non-Structural Protein 3 With A Discussion Of The Mutation's Effects On Viral Properties, Caden Connealy

Honors Program: Senior Projects (Public)

West Nile Virus (WNV), a member of the Flaviviridae family and introduced to the Western hemisphere in 1999, presents a unique and emerging threat to human health. Infection in humans is often mild but can occasionally result in severe neurological impairment and even death. West Nile Virus non-structural protein 3 (NS3) plays an important role in the process of viral genome amplification. More specifically, the C-terminal domain of the protein folds into a helicase enzyme, which is responsible for the “unwinding” of double-stranded RNA intermediates and RNA secondary structure on the WNV genome. This is a vitally important step in …

College Of Natural Sciences 2024 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 2 Dean's Message
Page 3 Department Highlights
Page 4 One Day for State
Page 5 New Students in Wecota
Page 6-8 Faculty Excellence
Page 9 SDSU Physics Students Recognized
Page 9 Prairie Doc Watch Party
Page 10-11 Student Excellence
Page 11 Connections Abroad
Page 12-13 CNS’s Research Centers
Page 14 Connections Abroad
Page 14 Dean Wolf-Hall Retired
Page 15 Outreach Program
Page 15 Events and Traditions
Page 16 Student Spotlight
Page 17 Alumni Spotlight
Page 18-19 SDSU Alum at Paris Paralympics
Page 20 Work Anniversaries & Programs

Identifying Herbicides To Manage Weeds In A Buckwheat Cover Crop And For The Control Of Volunteers, Taylor Randell-Singleton, Hannah E. Wright-Smith, Lavesta C. Hand, Jenna C. Vance, A. Stanley Culpepper

Horticulture Faculty Publications and Presentations

Buckwheat (Fagopyrum esculentum) is a fast-growing plant that quickly produces a dense groundcover. The utilization of buckwheat as a cover crop in vegetable production could be beneficial to Georgia producers, however for successful adoption, weed control in the cover crop coupled with control of buckwheat volunteers must be achievable. A preemergence (PRE) and a postemergence (POST) experiment were each conducted three times in Ty Ty, GA (2020-2021) addressing these objectives. In the PRE study, acetochlor at 0.56 lb ai acre(-1) injured buckwheat up to 16% without negatively influencing growth, suggesting potential for use in buckwheat for weed control. Flumioxazin, fomesafen, …

Genomics Yields Biological And Phenotypic Insights Into Bipolar Disorder, Kevin S. O’Connell, Maria Koromina, Tracey Van Der Veen, Toni Boltz, Ney Alliey Rodriguez

School of Medicine Publications

Bipolar disorder is a leading contributor to the global burden of disease¹. Despite high heritability (60–80%), the majority of the underlying genetic determinants remain unknown². We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.8 million controls), combining clinical, community and self-reported samples. We identified 298 genome-wide significant loci in the multi-ancestry meta-analysis, a fourfold increase over previous findings³, and identified an ancestry-specific association in the East Asian cohort. Integrating results from fine-mapping and other variant-to-gene mapping approaches identified 36 credible genes …

The Mechanistic Target Of Rapamycin Mediates Clostridium Perfringens-Induced Chicken Necrotic Enteritis Attenuated By Secondary Bile Acid Deoxycholic Acid, Mohit Bansal, Tahrir Alenezi, Ying Fu, Janashrit Shrestha, Ayidh Almansour, Hong Wang, Anamika Gupta, Rohana Liyanage, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a prevalent gut bacterial pathogen in humans and animals. This study investigated the role of the mechanistic targets of rapamycin (mTOR) and deoxycholic acid (DCA) on C. perfringens intestinal infection. Chickens were sequentially infected with Eimeria maxima and received the mTOR inhibitor rapamycin and DCA. C. perfringens-induced necrotic enteritis (NE) was evaluated using body weight gain (BWG), histopathology, bile acids, pathogen colonization, cell infiltration and death, and gene expression. The significant difference of p < 0.05 was analyzed by one-way ANOVA and multiple comparisons. Notably, rapamycin strongly reduced the subclinical and clinical NE histopathologies. DCA and DCA combined with rapamycin alleviated clinical NE and BWG loss. Rapamycin, DCA, and DCA + rapamycin attenuated bile acid reduction in NE birds, and they also reduced immune cell infiltration into the intestinal lamina propria as well as immune cell migration in vitro. At molecular levels, DCA and DCA + rapamycin reduced proinflammatory IFN gamma, MMP9, IL23, and IL17 gene expression. Rapamycin, DCA, and DCA + rapamycin reduced NE-induced intestinal cell apoptosis. Together, these results suggest that mTOR signaling mediates C. perfringens-induced ileitis, and combining mTOR inhibition and DCA improves the intervention efficacy against NE ileitis and BWG loss.

Mesenchymal Stem Cells Loaded In Injectable Alginate Hydrogels Promote Liver Growth And Attenuate Liver Fibrosis In Cirrhotic Rats, Dominic Karl M Bolinas, Allan John R Barcena, Archana Mishra, Marvin R Bernardino, Vincent Lin, Francisco M Heralde, Gouthami Chintalapani, Natalie W Fowlkes, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

Cirrhosis, a marker of severe liver diseases, limits future liver remnant (FLR) growth, preventing many cancer patients from undergoing surgery. While portal vein blockade (PVB) techniques are used to stimulate liver regeneration, 20-30% of patients still fail to achieve the required growth. Although mesenchymal stem cell (MSC) therapy improves PVB, its efficacy is limited by poor cell retention. To address this, we utilized alginate hydrogels to deliver MSCs and improve their retention. MSCs were loaded in the hydrogel and injected intraportally in cirrhotic rats. Liver volume, weights, enzyme levels, and histology were monitored. Results showed that the hydrogel maintained 89.0 …

Efficacy Of Baits And Lures For Weasel Detection, Scott M. Bergeson, Roland Kays, David S. Jachowski, Courtney D. Anderson, Chad R. Williamson, Ashley Burket, Joseph W. Butfiloski, Amanda E. Cheeseman, Stacy Cotey, Catherine C. Dennison, John D. Erb, Zach J. Farris, Michael L. Fies, Michael J. Joyce, Colleen Olfenbuttel, Blake Sasse, Lisa M. Smith, Joshua A. Tabora, Marketa Zimova

Michigan Tech Publications

Small mustelids are difficult to survey due to their low density and cryptic nature. Population status of North American weasels (Mustela erminea, Mustela nivalis, and Neogale frenata) are believed to be in decline, but there are no standardized monitoring protocols to evaluate their status. To support weasel monitoring, we compared the attractiveness of various combinations of baits and lures to weasels in sites located throughout the eastern and central USA. We baited a total of 122 clusters of 4 camera traps, across 14 states, with random combinations of 4 baits and 3 scent lures in the winters of 2022 and …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Parrotfeather (Myriophyllum Aquaticum): Biology And Management Options In Utah, Francielli S. De Oliveira

Spring Runoff Conference

Parrotfeather (Myriophyllum aquaticum)

• Invasive weed from South America.
• Heterophilic perennial dioecious plant (female in the US).
• Forms dense mats, blocks waterways, and outcompetes native species
• Spreads via rhizomes, stolons, and stem fragments.

Harvest Management And Regrowth Of Trifolium Alexandrinum, R E. Joost, J D. Mooso

IGC Proceedings (1977-2023)

Adaptation of berseem clover (Trifolium alexandrinum) beyond the coastal regions of the southeastern United States was limited by a lack of cold tolerance prior to the release of 'Bigbee', a selection from a stand of 'Sacromonte' subjected to temperature of -15 and -18 Con successive nights in 1972. The release of Bigbee in 1985 expanded the range of berseem clover adaptation to include the entire Southeast, as far north as Oklahoma (Knight, 1985). It is known that annual clovers do not rely on root reserve carbohydrates, but rather on residual leaf area and rapid leaf regeneration from active …

The Anorexigenic Peptide Nesfatin-1 Dampens The B Cell Response To Receptor-Mediated Stimulation Through Inhibition Of Nf-Kb Signaling, Tara L. Steffen, Joshua D. Stafford, Colleen R. Boche, Willis K. Samson, Gina Yosten

Biological Sciences Faculty Research & Creative Works

Nesfatin-1, a posttranslational product of the protein encoded by the nucleobindin 2 gene (NUCB2), was functionally identified as an appetite regulatory molecule in rat hypothalamic nuclei. In the years following the discovery, those findings have been corroborated and expanded upon, and we now know that nesfatin-1 is expressed throughout peripheral tissues and exerts physiological effects beyond feeding control. Literature indicates that adipose tissue is one of the peripheral sources of NUCB2/nesfatin-1, and in this setting, it has anti-inflammatory effects that have recently been implicated in regulating chronic inflammation associated with diet-induced obesity. Currently, there are gaps in our understanding of …

Marine Heatwave Conditions In Western Australia Marine Waters - 26th March 2025, Department Of Primary Industries And Regional Development, Western Australia

Marine Heatwave Notification Reports

Marine heatwave (MHW) conditions across the state have persisted. Category 1 – Moderate conditions continue for the Gascoyne and South Coast Bioregions. The North Coast Bioregion has returned to Category 1 – Moderate conditions. The West Coast Bioregion remains warm but is not categorised as experiencing MHW conditions.

Contrasting Effects Of Climate Warming On Hosts And Parasitoids: Insights From Rocky Mountain Aspen Leaf Miners And Their Parasitoids, Alisha A. Shah, Emily Hamant, Juan G. Rubalcaba, Beau Larkin, Andrew A. Forbes, H. Arthur Woods

Aspen Bibliography

Because temperature has pervasive effects on biological rates, climate warming may alter the outcomes of interactions between insect hosts and their parasitoids, which, for many host species, constitute the single largest source of mortality. Despite growing interest in parasitoid-host responses due to climate change, there are few empirical tests of thermal tolerance differences between non-model lepidopteran hosts and their parasitoids and almost none from mountain ecosystems where warming is occurring more rapidly. We examined the thermal ecology of a host–parasitoid interaction in the Rocky Mountains using the wild populations of the aspen leaf miner (Phyllocnistis populiella) and a …

Murine Studies On Ketogenic Modulation Of Metabolism And Epigenetics In Olfaction- Based Learning, Lps Inflammatory Response, And Sex Dimorphisms In Dietary Response, Sara E. H. Moss

USF Tampa Graduate Theses and Dissertations

Ketogenic diets are well-established therapeutic interventions for epilepsy, with documented neuroprotective effects arising from their metabolic, antioxidant and anti-inflammatory properties. Beyond epilepsy, ketogenic therapies are under investigation for various conditions including Alzheimer disease, cancer, diabetes, and cardiovascular disease. These diets suppress insulin levels and shift metabolic physiology toward fat and ketone body metabolism. This elevates circulating levels of ketone bodies, namely beta-hydroxybutyrate, acetoacetate, and acetone, which serve as both energy substrates and signaling molecules. The state of elevated ketone bodies (ketosis) can be achieved with various formulations of a ketogenic diet as well as exogenous ketone supplementation, though the signaling …

Draft Genome Data Including Functional Annotation Of An Emerging Fungal Pathogen (Neodothiora Populina) Causing A Canker Disease Of Trembling Aspen In Interior Alaska, Ursel M. E. Schütte, Mace Wages, Aaron Buechlein, Jorda P. Kovash, Danielle C. Wrenn, Tereza Smrhova, Andrea Zubrova, Doug B. Rusch, Loretta M. Winton, Gerard C. Adams, Roger W. Ruess, Mary Beth Leigh, Devin M. Drown

Aspen Bibliography

Neodothiora populina is a black yeast-like fungus in the family Dothioraceae. It causes an aggressive canker disease of trembling aspen that results in widespread mortality of aspen across the boreal forest of Interior Alaska. Here we report a high-quality draft genome including functional annotation of this emerging fungal pathogen based on Oxford Nanopore Technologies long-read sequences. Our initial genome assembly totaled 23,960,169 bp and contained 18 contigs, and we identified 7,343 genes. This resource announcement provides new genomic data that are useful long term for improving our understanding of forest health in Alaska.

Drug Targets Illumination: An Evidence-Based Data Analytics & Informatics Approach To Hypothesis Generation Through Clinical Trials And Genomic Variants, Jeremiah I. Abok

Chemistry and Chemical Biology ETDs

DRUG TARGETS ILLUMINATION: AN EVIDENCE-BASED DATA ANALYTICS & INFORMATICS APPROACH TO HYPOTHESIS GENERATION THROUGH CLINICAL TRIALS AND GENOMIC VARIANTS

Target Illumination Clinical Trial Analytics with Cheminformatics (TICTAC) introduces a scalable data integration pipeline that aggregates multivariate clinical trial evidence to systematically rank disease–target associations. By harmonizing metadata from AACT and employing confidence-scoring techniques, TICTAC facilitates hypothesis-driven target selection for drug discovery, enabling a data-driven approach to therapeutic development. In parallel, a bioinformatics-driven analysis of gnomAD exome mutations in the ZPR1 gene highlights the broader role of genetic variants in disease association. By employing variant effect predictors, protein stability modeling, and …

Barriers To Engagement Of Care For Patients Presenting With Comorbid Human Immunodeficiency Virus (Hiv) And Major Depression Or Anxiety Disorder Diagnoses, Rachel C. V. Kingsley

USF Tampa Graduate Theses and Dissertations

Despite significant global advancements in HIV care, engagement in continuous HIV care remains a challenge, particularly for individuals living with comorbid HIV and mental health disorders. This dissertation examines the barriers to continuous HIV care for those individuals living with comorbid HIV and depression and/or anxiety in the Tampa Bay area. This dissertation argues that dual health challenges are dually challenging. This study highlights how structural vulnerabilities, how feelings of inclusion and exclusion impact engagement in care, and socioeconomic challenges intersect to shape patient experiences and impact adherence to treatment. Drawing on critical medical anthropology, structural violence, embodied belonging, and …

Domain Communication In Bifunctional Proline Utilization A From Sinorhizobium Meliloti, Emma Bitterman

Honors Program: Senior Projects (Public)

The reduction potential of flavin bound to Sinorhizobium meliloti proline utilization A (SmPutA) is beneficial in providing vital information on enzyme activity and the active site environment. Flavin is crucial in biological metabolism such as aerobic respiration and other important processes like oxygen activation that are catalyzed by flavin-dependent enzymes. (4). In this study, we seek to determine whether the redox potential of SmPutA-bound flavin can be used to characterize potential long-distance communication and analyze the possibilities of inactivation reversibility. SmPutA is a large bifunctional enzyme that catalyzes the overall oxidation of proline to glutamate via two catalytic domains (1). …

Β-Catenin Drives The Foxc2-Mediated Epithelial-Mesenchymal Transition And Acquisition Of Stem Cell Properties, Maria Castaneda, Petra Den Hollander, Steve Werden, Esmeralda Ramirez-Peña, Suhas V Vasaikar, Nick A Kuburich, Claire Gould, Rama Soundararajan, Sendurai A Mani

Faculty, Staff and Student Publications

Background: Aggressive forms of breast cancer, such as triple-negative breast cancer (TNBC), are associated with an increase in cancer cells that exhibit stem cell properties. The activation of the epithelial-mesenchymal transition (EMT) program, mediated by the transcription factor FOXC2, generates these stem-like cells. FOXC2 is linked to poor prognoses across various cancer types and is notably upregulated in TNBC, where it establishes and sustains these stem-like cells within the tumor population.

Methods: Here, we decode the pathways regulating FOXC2 activation using EMT-enriched cell line models. Stemness was assessed using mammosphere assays and mesenchymal markers by western blot. Expression …

Per- And Polyfluoroalkyl Substance (Pfas) Degradation In Water And Soil Using Cold Atmospheric Plasma (Cap): A Review, Victor Somtochukwu Mbanugo, Boluwatife Stephen Ojo, Ta Chun Lin, Yue-Wern Huang, Marek Locmelis, Daoru Han

Biological Sciences Faculty Research & Creative Works

Per- and polyfluoroalkyl substances (PFASs) are persistent organic chemicals found in numerous industrial applications and everyday products. The excessive amounts of PFASs in water and soil, together with their link to severe health issues, have prompted substantial public concerns, making their removal from the environment a necessity. Existing degradation techniques are frequently lacking due to their low efficiency, cost-effectiveness, and potential for secondary contamination. Cold Atmospheric Plasma (CAP) technology has emerged as a promising alternative, utilizing energized reactive species to break down PFASs under ambient conditions. Therefore, this review examines the efficacy and effectiveness of CAP in degrading PFASs by …

Defining B Cell Responses To Emerging Viral Pathogens, Wafaa Al Soussi

Arts & Sciences Graduate Student Theses and Dissertations

The primary series of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines greatly reduced the burden of the coronavirus disease 2019 (COVID-19) pandemic and saved millions of lives. However, waning levels of circulating neutralizing antibodies and the continuous emergence of SARS-CoV-2 variants with increasing numbers of mutations in the spike (S) protein have decreased vaccine effectiveness and led to a recommendation for booster immunizations. In addition, new vaccines based on circulating variants have been developed to enhance the ability of induced antibodies to combat such variants. However, a critical unanswered question was how prior exposure to the ancestral SARS-CoV-2 strain …

Defining B Cell Responses To Emerging Viral Pathogens, Wafaa Al Soussi

Arts & Sciences Graduate Student Theses and Dissertations

The primary series of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines greatly reduced the burden of the coronavirus disease 2019 (COVID-19) pandemic and saved millions of lives. However, waning levels of circulating neutralizing antibodies and the continuous emergence of SARS-CoV-2 variants with increasing numbers of mutations in the spike (S) protein have decreased vaccine effectiveness and led to a recommendation for booster immunizations. In addition, new vaccines based on circulating variants have been developed to enhance the ability of induced antibodies to combat such variants. However, a critical unanswered question was how prior exposure to the ancestral SARS-CoV-2 strain …

Soil Health And Water Conservation, Tony Richards

Spring Runoff Conference

What are Healthy Soils? 

• Stable 
• Functional 
• Productive 
• Resilient