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Cost Effectiveness Analysis Of Psychopharmaca Therapy Combination Compared With Psychopharmaca Therapy And Ect Combination In Schizoaffective Inpatients At The Rsj Provinsi Jawa Barat, Yasmin Fadillah, Sani Asmi Ramdani Lestari, Ardilla Kemala Dewi

Pharmacology and Clinical Pharmacy Research

Mental disorders constitute an economic burden on health, estimated at USD 2.5 trillion in 2010 and expected to increase to USD 6 trillion by 2030. Treatment of schizoaffective disorder involves a combination of medication and psychotherapy. Pharmacoeconomics is an important consideration in drug selection. This study aims to determine the cost-effectiveness of psychopharmaca therapy combination compared with psychopharmaca therapy and ECT combination in schizoaffective inpatients at the RSJ Provinsi Jawa Barat. Data collection was conducted retrospectively from patient medical records for the period December 2023–December 2024. Total costs, based on a health perspective, include psychopharmaca drug costs, inpatient care costs, …

Evaluation Of Antibiotic Use Using The Gyssens Method On Clinical Outcomes In Ischemic Stroke Patients, Juniarto Mende, Graciano A. Maturbongs, Yohana K. A. Mbulang

Pharmacology and Clinical Pharmacy Research

Ischemic stroke is a health problem that causes death and neurovascular disability worldwide. The inflammatory response due to infection can increase ischemic stroke and increase brain damage through changes in blood pressure, coagulation, immune response, and endothelial function. This study aims to evaluate the rationality of antibiotic use on clinical outcomes in ischemic stroke patients. This study used a cross-sectional design. Retrospective data were taken from the medical records of Jayapura Regional Hospital for the period January 1, 2023, to May 31, 2025. The study subjects were all patients who suffered ischemic stroke and received antibiotics. Evaluation of the rationality …

Analysis Of Pharmacotherapy And Non-Pharmacotherapy Burden From The Ina-Cbgs Package For Cesarean Section Surgery At The Regional General Hospital Dr. Soedarso In 2023, Ananda Rizky Awwaliyah, Nurmainah Nurmainah, Ridha Ulfah

Pharmacology and Clinical Pharmacy Research

The prevalence of cesarean sections has been increasing each year. Previous studies show that the cost of medications and medical supplies for cesarean patients accounts for one-third of the total care costs. In the era of National Health Insurance (NHI), medications and medical supplies are considered operational expenses for hospitals rather than sources of income. This condition requires proper medication management and the use of medical supplies. This study aims to analyze the percentage of pharmacotherapy and non-pharmacotherapy, including the types and quantities of medications as well as disposable medical supplies used on patients undergoing cesarean section procedures at the …

Alexithymia In Substance Use Disorders: A Scoping Review Of Therapeutic Approaches, Pratami Diah Herliani, Shelly Iskandar, Angela Vera Herman Efendi

Pharmacology and Clinical Pharmacy Research

Alexithymia, defined as the inability to recognize and express emotions, has a high prevalence (40–50%) among individuals with substance use disorders (SUD), particularly alcohol use disorder, and is associated with poorer clinical outcomes. Despite this, comprehensive mapping of psychotherapeutic interventions targeting this condition within the SUD population remains limited. This study aimed to systematically map the therapeutic approaches investigated to address alexithymia among individuals with substance use disorders and to summarize the reported outcomes. A scoping review was conducted in accordance with the PRISMA-ScR guidelines using systematic literature searches in the PubMed and Scopus databases. Relevant studies were screened based …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

Geographic And Environmnetal Influences On Color Pattern Similarity Between Coral Snakes (Genus: Micrurus) And Their Lookalikes, Anthony Sena

Dissertations

Venomous coral snakes and their lookalikes are often regarded as a classic example of Batesian mimicry, whereby a harmless species imitates a harmful species. The existing literature regarding coral snake resemblance presents a divisive stance on whether Batesian mimicry is the primary driver of shared color patterns or if alternative factors are responsible. While recent literature largely favors the Batesian hypothesis, empirical support remains inconsistent, and the specific geographic and interpretation of the conditions required for mimicry lacks consensus within the scientific community.

To evaluate the mechanisms maintaining these phenotypes, a quantitative, multivariate framework was utilized to analyze 400 museum …

The Association Between Rapid Growth In Children Under The Age Of Five And Adolescent Obesity, Ratu Ayu Dewi Sartika, Fadila Wirawan, Iche Andriyani Liberty, Nurul Husna Mohd Shukri, Siti Arifah Pujonarti, Edy Purwanto, Munaya Fauziah

Kesmas

Early-life nutrition is a critical predictor of long-term health, yet the association between rapid early-childhood growth and adolescent obesity, particularly in relation to the “double burden of malnutrition,” remains under-researched in Indonesia. This study aimed to analyze the association between rapid growth and adolescent obesity. Data were obtained from the 1997, 2000, and 2014 waves of the Indonesian Family Life Survey (IFLS). This study included 641 children (aged 0–23 months at baseline) with complete anthropometric measurements across all three waves. Rapid growth was defined as an increase in z-scores of >0.67 in weight-for-age (WAZ), height-for-age (HAZ), or weight-for-height (WHZ) between …

Environmental Perspective For System Dynamics Modeling Of Stunting Mitigation To Achieve The Sustainable Development Goals In West Sumatra, Indonesia, Elsa Yuniarti, Nabila Azzahra, Yulhendri Yulhendri, Heldi Heldi, Mery Delvina, Saskia Putri Azeli

Kesmas

This study developed a system dynamics model to simulate stunting reduction in West Sumatra Province, Indonesia, by integrating infant and toddler health, maternal health, and environmental determinants. Secondary data from 2020–2024 on low birth weight, immunization, malnutrition, exclusive breastfeeding, maternal chronic energy deficiency, iron and folic acid supplement distribution, sanitation, and safe drinking water access were compiled from West Sumatra Provincial Health Office and Statistics Indonesia, and validated through consultation with five stakeholder institutions. Causal Loop Diagrams mapped feedback relationships among determinants and were translated into Stock Flow Diagrams using Powersim Studio 10. The model was validated through structural verification, …

Outcome Evaluation Of Percutaneous Coronary Intervention Vs Medical Therapy Alone In Patients With Chronic Coronary Syndrome, Hsien-Yuan Chang, Hsin-Yu Fang, Mu-Shiang Huang, You-Zhen Chen, Di-Yung Chen, Edward Chia-Cheng Lai, Jung-Der Wang, Yi-Heng Li, Li-Jung Elizabeth Ku

Journal of Food and Drug Analysis

This study provides real-world evidence by comparing the long-term clinical outcomes of percutaneous coronary intervention (PCI) versus medical therapy alone in patients with chronic coronary syndrome (CCS) diagnosed non-invasively, given the lack of evidence in this population. This retrospective cohort study (2013-2018) utilized data from a medical center’s Cardiovascular Disease Databank, which was linked to national mortality records in Taiwan. Propensity score matching (PSM) and stabilized inverse probability of treatment weighting (IPTW) were applied to adjust for baseline differences between the PCI and medication-only groups. Major adverse cardiovascular events (MACE), including all-cause mortality, non-fatal myocardial infarction (MI), and revascularization, were …

Mitochondrial Trna-Derived Fragments As Candidate Metastasis-Modifying Rna, Katy L. Swancutt, R. Mckinnon Walsh, Sydney Quijano, Emily Schueddig, Devin C. Koestler, Adam D. Scheid, Tony Vanden Bush, Yi Jing, Isidore Rigoutsos, Danny R. Welch

Computational Medicine Center Faculty Papers

UNLABELLED: How mitochondrial DNA (mtDNA) polymorphisms influence complex phenotypes remains poorly understood. Using mitochondrial-nuclear exchange mice, we previously showed that mtDNA single-nucleotide polymorphisms (SNP) modify metastasis, cardiovascular disease, and epigenetic marks independently of metabolic differences. The only mtDNA SNP correlating with these phenotypes resides in the gene encoding mitochondrial transfer RNA (tRNA)-arginine [mt-tRNAArg (UCG), mt-TR], suggesting a role for non-protein-coding loci. In this study, we identify and preliminarily characterize previously undescribed tRNA-derived fragments (tRF) generated from mt-TRs. Northern blotting revealed distinct tRF that are differentially expressed among mtDNA SNPs, between lung and liver, and between sexes. Surprisingly, small RNA sequencing …

American Plum Borer In Utah Orchards (Euzophera Semifuneralis), Emilie Demard, Marion Murray, Claudia Nischwitz

All Current Publications

This fact sheet provides information on American plum borer in Utah orchards, also known as APB. This pest primarily damages fruit trees. APB moths were detected in traps in 2026, but to date, no tree damage has been found. This fact sheet discusses hosts, identification, and management methods.

Bryophyte Community Composition In A Second-Order Tropical Stream At The Luquillo Experimental Forest, Puerto Rico, Cecilia Sahnow, Jean P. González-Crespo, Amelia Merced

Biology Faculty Publications and Presentations

Streams are important ecosystems that harbor a high diversity of plant species including bryophytes. Studies suggest streams can function as refugia and/or corridors that buffer against the effects of disturbances. In this study, we sampled five sites along a second-order tropical stream in the Luquillo Experimental Forest. We described the riparian bryophyte community composition in conjunction with the physical structure of the stream to understand what environmental factors influence bryophyte composition in the stream. We identified 56 bryophytes, 33 liverworts and 23 mosses; and we recorded cyanobacteria associated with over half of the species of bryophytes. Rocks were the most …

Utah Vegetable Production Guide (5th Edition), Nick Volesky, Marion Murray, Amelia Olds, Bridger Carey

All Current Publications

This guide, written by a collection of Utah State University (USU) Extension faculty and specialists, provides information on general Utah vegetable production, soil, nutrient, and water management, integrated pest management practices, and pesticides. The included chapters cover various vegetable crops, including brassicas, cucurbits, leafy greens, potatoes, legumes, onions, root crops, sweet corn, and solanaceous crops.

Oregon State Rank Assessment For Schweinitz's Cyperus (Cyperus Schweinitzii), Nora Dunkirk

Institute for Natural Resources Publications

Oregon state conservation status assessment for Schweinitz's cyperus (Cyperus schweinitzii) using NatureServe methodology, 2026.

Nasa’S Ecostress Satellite Reveals Widespread Midday Depression In Ecosystem Evapotranspiration, Jingyi Bu, Jingfeng Xiao, Joshua B. Fisher, Yiqi Luo

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Plants often exhibit a midday depression in water use (i.e., transpiration), reflecting a constraint on their ability to sustain maximum water transport, which may occur at the cost of reduced photosynthesis. Eddy covariance observations and geostationary satellites cannot quantify this widespread phenomenon globally while resolving fine-scale spatial variability. Using evapotranspiration measurements from the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) and machine learning, we quantify the global distribution of midday depression in evapotranspiration. Midday depression primarily occurs during peak-growing seasons in temperate zones and dry periods in the tropics, with a morning shift of the peak evapotranspiration time …

Oregon State Rank Assessment For Koehler's Rockcress (Boechera Koehleri), Lindsey K. Wise, Gabriel Campbell

Institute for Natural Resources Publications

Oregon state conservation status assessment for Koehler's rockcress (Boechera koehleri) using NatureServe methodology, 2026.

The Role Of Seed Mix Characteristics And Soil Amendments During Post-Agricultural Prairie Restoration, Valerie N. Thurston, Michaela J. Woods, Madelaine Gregory, Mary C. Lloyd, Ryan W. Mcewan

Biology Faculty Publications

Introduction: Prairie restoration on degraded lands may be influenced by seed mix characteristics, including species richness and legume establishment. Soil amendments may facilitate restoration; however, the practical usefulness of techniques such as applications of whole soil and leaf mulch remains relatively unclear.

Objectives: We assessed whether increasing species richness and legume content in seed mixes enhances prairie restoration success and examined how soil amendments interact with seed mix composition to influence cover, species richness, diversity, and legume establishment.

Methods: We conducted a field experiment on a 12-ha post-agricultural site in Ohio, U.S.A. Twenty 50 × 50 m plots received one …

Beyond Better Conditions: Seaweed Farming And The Number Of Sentient Animals In Aquaculture, Shrilaxmi Patil, Matthew Unerman, Wasseem Emam

Animal Sentience

Oldfield & Bonano (2024) (O&B) document how far  fish welfare research lags behind welfare research in other animals. We share O&B’s feelings-based concept of welfare and agree that aquaculture seeded this field; but research volume has not scaled with animal numbers: Welfare attention per farmed fish or decapod remains negligible. Along the lines of preceding commentaries (Maia 2024, Mather 2024), we treat farmed aquatic animals as individuals rather than tonnage. We then raise a point so far absent from the commentary on O&B so far: reducing the number of sentient animals entering intensive systems. Coastal seaweed farming, which cultivates non-sentient …

Determining The Feasibility Of A Habituation Assessment In Managed Red Wolves, Emily C. Lynch, Joseph W. Hinton, Jennifer B. Nagashima, Curtis Malott, Natalie J. Johnson, Emily Haering, Robin Petersen, Allison Johnson, Julie K. Young

Wildland Resources Faculty Publications

For species extirpated from the wild, ex situ breeding programs are essential for providing the individuals necessary for re-establishing wild populations through reintroductions. However, repeated exposure to humans under managed care may reduce wariness and alter behavioral responses in ways that are maladaptive after release. Although some pre-release behaviors reflect natural responses essential for survival and reproduction, others may result from habituation to humans and increase the risk of conflict, recapture, or mortality following translocation. These risks underscore the need for behavioral assessments to help identify appropriate candidates for release. However, because the assessments themselves require some exposure to humans, …

Effects Of Intensive Exercise On The Blood Chemistry Of Fighting Bulls In Southern Thailand, Siriwat Wasiksiri, Pratthana Yongsakulchai, Wichaya Thongtako, Paradorn Muangnil, Teepakorn Adulkasem

The Thai Journal of Veterinary Medicine

Bullfighting is a cultural activity in southern Thailand. Bulls walk and undergo intensive exercise before competition. In the arena, winners are determined by their opponents' surrender, so bulls do not die after fighting. However, there are very few studies on organ injuries in living bulls during these activities. This study compared the effects of walking and intensive exercise on complete blood count (CBC) and blood chemistry. Blood parameters of 14 Thai fighting bulls aged over 6 years, regularly trained for walking and intensive exercise, were measured and analyzed using a paired t-test or Wilcoxon signed-rank test. Eosinophils decreased significantly after …

Pathways For Coordinating High-Quality Exploitation Of Marine Resources And High-Level Protection Of Marine Ecosystems, Jianping Yin, Peimin Duan, Si Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The ocean serves as a vital strategic space and a reservoir of resources essential for human survival and development, offering robust support for socioeconomic progress. Simultaneously, as a critical component of the Earth’s ecological environment, the ocean plays a pivotal role in regulating climate change, conserving biodiversity, and maintaining ecological balance. In recent years, China has continuously intensified the exploitation and utilization of marine resources, with the growth of the marine economy injecting blue momentum into the nation’s development. Nevertheless, the long-term, high-intensity exploitation of offshore resources, coupled with the ongoing advancement into deep-sea resource development, has led to frequent …

Policy System Of Us Bioeconomy Based On “3ms” Framework, Jingyan Zhou, Nianping Tian, Xuehui Jin, Cuijuan Yin

Bulletin of Chinese Academy of Sciences (Chinese Version)

The United States is a dominant power in the global bioeconomy. An in-depth analysis of its policy system characteristics holds significant reference value for China to further formulate China’s bioeconomy strategy and drive the development of China’s bioeconomy. This study employs the “3Ms” policy analysis framework to conduct a comprehensive analysis of the US bioeconomy policy from three dimensions: macro strategy, meso architecture, and micro structure. The research reveals that the US bioeconomy policy demonstrates the following characteristics in the macro strategy: being systematic, comprehensive, and scientifically decision-making; in the meso architecture: forming government-congressional cooperation and multi-party collaboration; and in …

Cells And Networks In Flux: Rethinking Ontogenesis And Pathogenesis, Mark L. Tykocinski

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Organ and tissue functions emerge from the coordinated activity of cell networks. Therapeutics that act on pathogenic cell networks, modulating their cellular interplay, follow naturally. Over several decades, our laboratory has developed a series of approaches for rewiring cell networks, culminating in a class of cell surface-directed signal converter proteins (SCPs) that do so by modulating juxtacrine and autocrine signaling in and among their nodal cells. A first such SCP has now produced encouraging clinical data for cancer immunotherapy. Yet, these early network-directed fusion proteins rest on a deliberately simplified picture: discrete end-cell types plugged into graphically tractable networks. That …

Food Insecurity Among Freshman Male Collegiate Athletes At A Historically Black University In Maryland, Petita Cue Rentz

Walden Dissertations and Doctoral Studies

Food insecurity is an emerging public health issue impacting collegiate student-athletes enrolled at Historically Black Universities (HBUs). Recent research revealed that 63% of football players have reported some form of food insecurity which disproportionately impacts Black athletes at higher rates. The purpose of this qualitative study was to explore the lived experiences and dietary behaviors of freshman male collegiate student-athletes who lacked access to food despite receiving athletic scholarships in a publicly funded HBU in Maryland. The research questions for this qualitative study focused on exploring the lived experiencing of Black male athletes who were experiencing food insecurity at an …

The Invisible Crop: Harnessing Root System Architecture In Heirloom Collards For Climate-Resilient Urban Agriculture, Vincent Antonio Brazelton

Arts & Sciences Graduate Student Theses and Dissertations

Growing food in urban spaces often means working within variable, resource-limited environments, creating a need for crops that can withstand heterogeneous growing conditions. Heirloom collards (Brassica oleracea var. viridis) are known for their aboveground diversity and cultural importance, but much less is known about the variation that exists belowground. This dissertation examines root system architecture (RSA) diversity across 19 historically underutilized heirloom collard accessions using a multi-scale phenotyping approach that includes controlled gel-based imaging of seedlings and 2D imaging of mature field-grown root systems. Across both seedling and mature stages, heirloom collards showed substantial variation in RSA. These differences revealed …

The Influence Of Circadian Rhythm Disruption And Apoe4 On The Prognosis And Progression Of Alzheimer’S Disease, Kayla Bradby

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Alzheimer’s disease is characterized by cognitive decline and memory loss and is the most common form of dementia. Genetic factors such as apolipoprotein E have been significantly associated with AD development and progression, most specifically the APOE4 isoform. Emerging evidence has shown that when the body’s circadian rhythm, the 24-hour dark/light cycle, is disrupted, the potential to develop a neurodegenerative disease such as AD increases. The purpose of this literature review is to examine the relationship between AD, circadian rhythm, and the APOE isoforms. This review puts a particular emphasis on the APOE4 isoform, as it has been shown to …

Mindful Parenting And Toddlers' Food Responsiveness: The Role Of Controlling Feeding Practices, Qingyu Jiang, Holly Wilhite, Natalie A. Williams, Dipti A. Dev, Caron A. C. Clark, Pearl Avari, Sarah B. Ladd

Journal of Extension

Controlling feeding practices may negatively impact children's eating behaviors. Mindful parenting may offer a promising way to reduce the use of these practices. This study examined the mediating role of pressuring children to eat and using food as a reward in the association between mindful parenting and toddlers' food responsiveness. Results indicated that higher levels of mindful parenting were associated with lower pressuring to eat, which was related to lower food responsiveness in toddlers. The results may inform Extension professionals providing mindfulness strategies for mothers of young children to improve feeding practices, ultimately reducing children's unhealthful eating behaviors.

Osteoporosis Knowledge, Health Beliefs, And Calcium Intake Among Malaysian Chinese Adults In Perak: A Cross-Sectional Study, Thean Hui Ru, Nurul Aimi Ab Kadir, Fatin Izzaty Mohd Shahrin

Makara Journal of Health Research

Background: The Malaysian Chinese population records the highest national prevalence of osteoporotic hip fractures. This study investigated the relationships between osteoporosis knowledge, health beliefs, and calcium intake among Malaysian Chinese adults.

Methods: A cross-sectional study was conducted among 205 Malaysian Chinese adults in Kampar, Perak, using the adapted Osteoporosis Prevention and Awareness Tool (OPAAT), Osteoporosis Health Belief Scale (OHBS), and a 30-item Food Frequency Questionnaire (FFQ).

Results: Participants demonstrated low osteoporosis knowledge (6.84 ± 2.92), with low perceived susceptibility (14.87 ± 5.00), moderate perceived seriousness (17.81 ± 5.20), and barriers to calcium intake (15.61 ± 4.15), and …

Technologies To Remoisturize Alfalfa In The Windrow For Baling, Earl Creech, Ryan Larsen, Matt Yost, Mark Nelson, Mckenna Barney

All Current Publications

Having the correct moisture at the time of baling is critical to maximizing economic return. In 2020 and 2021, researchers at Utah State University studied moisturization technologies to determine their impact on alfalfa yield, quality, and economic return. This fact sheet provides a research overview and study results on bale moisture and weight, yield, quality, and visual appearance. An economic analysis is also included.

Dissecting Tumor Evolution And Immune Composition In Prc2 Loss (H3k27me3 Loss) Vs Retained Mpnst, Kuangying Yang

Arts & Sciences Graduate Student Theses and Dissertations

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise sporadically or in the setting of neurofibromatosis type 1 (NF1). Although benign plexiform neurofibromas (PNs) are common in NF1, only a subset undergo malignant transformation, and the molecular events that define high-risk progression remain incompletely understood. A major axis of biological heterogeneity in MPNST is loss of Polycomb Repressive Complex 2 (PRC2), commonly detected through loss of H3K27me3 and frequently mediated by alterations in SUZ12 or EED. This dissertation integrates three manuscript-based studies to define genomic resources, tumor-intrinsic vulnerabilities, and immune microenvironmental remodeling in NF1-associated peripheral nerve sheath tumors, …