Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Life Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1831 - 1860 of 116327

Full-Text Articles in Entire DC Network

Species Identification Using Otolith Morphometry Of Four Gurnards (Family: Triglidae) From  Edremit Bay (Aegean Sea), Ahmet Mert Şenbahar, Di̇lek İlhan, Aydin Ünlüoğlu, Sencer Akalin Mar 2026

Species Identification Using Otolith Morphometry Of Four Gurnards (Family: Triglidae) From  Edremit Bay (Aegean Sea), Ahmet Mert Şenbahar, Di̇lek İlhan, Aydin Ünlüoğlu, Sencer Akalin

Turkish Journal of Zoology

Shape and size analyses of otoliths are widely considered appropriate tools for distinguishing between fish species and for assessing populations and stocks.  The present study aims to distinguish four gurnard species collected from Edremit  Bay (Aegean Sea) based on variations in their otolith shape morphology. A total of 60  specimens of Eutrigla gurnardus, 64 of Chelidonichthys lastoviza, 60 of  Chelidonichthys lucerna, and 60 of Lepidotrigla cavillone were analyzed. No  significant intraspecific differences were noted in the morphology of the left and right  otoliths, and so only the left sagittal otoliths were subjected to further analysis. Otolith  shape was quantified using …


Western Conifer Seed Bug (Leptoglossus Occidentalis), Emilie Demard Mar 2026

Western Conifer Seed Bug (Leptoglossus Occidentalis), Emilie Demard

All Current Publications

This fact sheet provides information on the western conifer seed bug, including native range, life cycle, plant hosts, symptoms and damage, and management options.


Latest Sightings Of The Striped Hyena In North Africa: Major Threats And Conservation Actions, Abderrazak El Alami, Abderrazzak Fattah, Ilyas El Alami, Ziad El Alami Mar 2026

Latest Sightings Of The Striped Hyena In North Africa: Major Threats And Conservation Actions, Abderrazak El Alami, Abderrazzak Fattah, Ilyas El Alami, Ziad El Alami

Turkish Journal of Zoology

The striped hyena (Hyaena hyaena) is widely distributed across the northern half of Africa, the Middle East, the Arabian Peninsula, and parts of Asia. However,  numerous studies indicate that this carnivore is in decline, and it is currently classified  as near threatened on the IUCN Red List of threatened species. In North  Africa, the Hyaena hyaena barbara subspecies has been extirpated from many  areas. This article summarizes data collected from observations of the striped hyena  in North Africa between 2004 and 2024. Among the 418 striped hyenas recorded in  North Africa between 2004 and 2024, 18.4% (n = 77) were …


Genetic Variants And Molecular Components Associated With Metabolic Dysfunctional-Associated Steatotic Liver Disease And Depression: Shared Association Of Adamts7 And Thrap3, Eron G. Manusov, Vincent P. Diego, Marcio A. Almeida, Jacob A. Galan, Kathryn Herklotz, Edwardo Abrego Ii, Habiba Sultana, Luis A. Peña Marquez, Marco Arriaga, Marcelo Leandro, Juan M. Peralta, Ana C. Leandro, Tom Howard, Joanne Curran, Sandra Laston, John Blangero, Sarah Williams-Blangero Mar 2026

Genetic Variants And Molecular Components Associated With Metabolic Dysfunctional-Associated Steatotic Liver Disease And Depression: Shared Association Of Adamts7 And Thrap3, Eron G. Manusov, Vincent P. Diego, Marcio A. Almeida, Jacob A. Galan, Kathryn Herklotz, Edwardo Abrego Ii, Habiba Sultana, Luis A. Peña Marquez, Marco Arriaga, Marcelo Leandro, Juan M. Peralta, Ana C. Leandro, Tom Howard, Joanne Curran, Sandra Laston, John Blangero, Sarah Williams-Blangero

Human Genetics Publications

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and depression frequently occur together. Identifying the genes that influence both MASLD and depression may facilitate the discovery of biological pathways associated with disease risk.

Methods: We recruited 525 participants from Mexican American families living in the Rio Grande Valley of south Texas. We collected clinical data, biometric measurements, hepatic health assessments using Vibration-Controlled Transient Elastography (VCTE), and depression evaluations determined with the Beck Depression Inventory-II. We estimated the heritability (h2) of MASLD-related measures, depression status, aspartate aminotransferase (AST), alanine aminotransferase (ALT), the AST/ALT ratio, and Vibration-Controlled Transient Elastography measurements. For each gene, …


Culvert Retrofit With Green Filter Media For The Removal Of Phosphorus From Stormwater Runoff, Somdipta Bagchi, Zhiming Zhang, Olayinka Olayiwola, Bharadwaj Mandala, Rupali Datta, Subhasis Giri, Richard Lathrop, Dibyendu Sarkar Mar 2026

Culvert Retrofit With Green Filter Media For The Removal Of Phosphorus From Stormwater Runoff, Somdipta Bagchi, Zhiming Zhang, Olayinka Olayiwola, Bharadwaj Mandala, Rupali Datta, Subhasis Giri, Richard Lathrop, Dibyendu Sarkar

Michigan Tech Publications

Phosphorus is a ubiquitous contaminant in urban and agricultural landscapes. A retention basin located in the southern part of Barnegat Bay, New Jersey, was identified as receiving stormwater runoff with elevated phosphorus concentrations. The basin is surrounded by expanding urban development, contributing to the progressive degradation of water quality in the bay, which is already highly eutrophic. This study evaluated the effectiveness of a culvert retrofit with a green filter media composed of granulated-aluminum-based drinking water-treatment residuals (Al-WTR) and granular carbon (5:1 ratio, w/w) for the removal of phosphorus and suspended sediments from stormwater runoff. The performance of the filter …


Primary School Physical Activity Culture In The Uk: Findings From A Four-Month Rapid Ethnography In Three Schools, Robert Walker, Lydia Emm-Collison, Danielle House, Simoona Kent-Saisch, Ruth Salway, Alice Porter, Abi Howard, Tom Reid, Michael Beets Med, Mph, Phd, Frank De Vocht, Russell Jago Mar 2026

Primary School Physical Activity Culture In The Uk: Findings From A Four-Month Rapid Ethnography In Three Schools, Robert Walker, Lydia Emm-Collison, Danielle House, Simoona Kent-Saisch, Ruth Salway, Alice Porter, Abi Howard, Tom Reid, Michael Beets Med, Mph, Phd, Frank De Vocht, Russell Jago

Faculty Publications

Introduction: Physical activity is fundamental for children’s health and well-being, yet most children are not active enough. School-based interventions aiming to increase children’s physical activity have largely been ineffective, perhaps due to a lack of consideration of the unique culture within each school. The aim of this paper is to understand the key aspects of physical activity culture in English primary schools using the organizational culture framework.

Methods: A four-month rapid ethnography study was conducted within three primary schools in Bristol, UK, between March and July 2024. The findings draw on observations, interviews, documentary data, photo elicitation, informal conversations and …


Is The Long-Horned Grasshopper Ruspolia Differens (Orthoptera: Tettigoniidae) A Novel, Nutritious, Functional, And Safe Alternative Food Product? A Review, Margaret Kababu, Collins Mweresa, Dorothy Nakimbugwe, Geoffrey Ssepuuya, Karlmax Rutaro, Nicodemus Matojo, Faith Nyamu, Robert Mbeche, Sevgan Subramanian, Sunday Ekesi, Chrysantus Tanga Mar 2026

Is The Long-Horned Grasshopper Ruspolia Differens (Orthoptera: Tettigoniidae) A Novel, Nutritious, Functional, And Safe Alternative Food Product? A Review, Margaret Kababu, Collins Mweresa, Dorothy Nakimbugwe, Geoffrey Ssepuuya, Karlmax Rutaro, Nicodemus Matojo, Faith Nyamu, Robert Mbeche, Sevgan Subramanian, Sunday Ekesi, Chrysantus Tanga

All Peer-Reviewed Publications

Ruspolia differens Serville (Orthoptera: Tettigoniidae) is among the most widely consumed edible insect in Eastern and Central Africa, where it contributes to both household nutrition and income generation. As a nutrient-dense food source, it offers a promising alternative to curb food insecurity and malnutrition. Despite this, the consumption and use of the grasshopper is limited to its seasonal availability when it is collected from the wild. Coupled with this, is limited evidence on its domestication despite research advances to optimize conditions for mass production. This review was conducted to highlight research advances and gaps on production, processing, nutritional profile, and …


Exploring The Influence Of Environmental Motivations On Consumer Attitudes And Purchase Intentions Toward Upcycled Foods, Peng Lu, Jennifer Waldeck, Keith Weber, Hualu Zhou Mar 2026

Exploring The Influence Of Environmental Motivations On Consumer Attitudes And Purchase Intentions Toward Upcycled Foods, Peng Lu, Jennifer Waldeck, Keith Weber, Hualu Zhou

Communication Faculty Articles and Research

Food loss and waste (FLW) present pressing environmental and economic challenges. Upcycling technologies provide a sustainable pathway by transforming food by-products into value-added products; however, consumer acceptance remains a critical barrier. Guided by Self-Determination Theory (SDT), this study investigates how environmental motivations influence consumers’ attitudes and purchase intentions toward milk enriched with upcycled peanut skins. Data were collected from a nationally representative sample of 1488 U.S. adults. Structural equation modeling (SEM) was employed to test hypothesized relationships among motivational constructs, and cluster analysis was used to identify consumer segments based on motivational profiles. The results show that intrinsic motivation and …


Visdb 20: A Manually Curated Resource Of Viral Integration Sites And Their Regulatory Maps In Human Diseases, Citu Citu, Ajeet Singh, Xinyi Liu, Mounika Ashannagari, Rinki Ratnapriya, Zhongming Zhao Mar 2026

Visdb 20: A Manually Curated Resource Of Viral Integration Sites And Their Regulatory Maps In Human Diseases, Citu Citu, Ajeet Singh, Xinyi Liu, Mounika Ashannagari, Rinki Ratnapriya, Zhongming Zhao

Faculty, Staff and Student Publications

The integration of viral sequence into the human genome plays critical role in the onset of various diseases, especially cancers. To facilitate systematic analysis of these events, we present VISDB 2.0, an expanded and updated database of human viral integration sites (VISs). The current release contains more than 270,000 manually curated VISs derived from 209 peer-reviewed publications, covering 11 viruses, including four retroviruses and seven DNA viruses. This represents a 3.5-fold increase in VIS entries compared with the previous version. Each VIS record includes standardized genomic coordinates and annotations describing local genomic context, CpG islands, repetitive elements, chromosomal fragile sites, …


Hallucinogens For Mood And Anxiety Disorders: A Critical Review Of Psychedelic-Assisted Therapies, Georgia Chlebek Mar 2026

Hallucinogens For Mood And Anxiety Disorders: A Critical Review Of Psychedelic-Assisted Therapies, Georgia Chlebek

The Cardinal Edge

In quite a few people worldwide, there are several mental disorders that prevent the brain from operating in the “proper” way, depression, anxiety, and post-traumatic stress disorder (PTSD) being among the most common. Luckily, there are several medications that are produced and used to treat these disorders, but some medications are hard to access, and others simply don’t help the patient. Firstly, these medications take time to study and prove safe for public use, though in some cases time is not readily available. In other cases, these medications are going through shortages and becoming increasingly difficult for patients to access …


Asimina Triloba (L.) Dunal: The Complete Story Of America’S Forgotten Fruit, Autumn M. Howard Mar 2026

Asimina Triloba (L.) Dunal: The Complete Story Of America’S Forgotten Fruit, Autumn M. Howard

The Cardinal Edge

Asimina triloba, commonly known as the pawpaw, is a unique and historically significant native fruit tree of the eastern United States. This research paper explores the taxonomy, botanical description, distribution, habitat requirements, ecological interactions, economic importance, and reproductive biology of A. triloba. The species is distinguished by its tropical-flavored fruits, adaptation to temperate climates, and reliance on clonal reproduction and specific insect pollinators. While offering promising opportunities for sustainable agriculture and riparian restoration, A. triloba faces challenges related to limited seed dispersal, susceptibility to certain pests and diseases, and the presence of neurotoxic compounds. Despite its historical importance …


Lamin A/C And Linc Complex Expression Affects Nuclei's Mechanical Properties And Functions In Osteosarcoma, Shridha Rajeswar Mar 2026

Lamin A/C And Linc Complex Expression Affects Nuclei's Mechanical Properties And Functions In Osteosarcoma, Shridha Rajeswar

The Cardinal Edge

The nucleus has long been simplified in the field of biology, despite being an important organelle. Until recently, it has been commonly depicted as a simple sphere located at the center of a cell, responsible mainly for regulating protein synthesis. However, current research indicates that the linkers of the nucleoskeleton and cytoskeleton (LINC) complexes, the pillars of nuclear architecture, play a critical role in maintaining nuclear integrity and function. These complexes interact with proteins, such as Lamins, that modulate responses to biomechanical stimuli through the regulation of gene expression. As such, when these structures are downregulated, they can contribute to …


Crepe Myrtle Bark Scale (Acanthococcus Lagerstroemiae) And Sooty Mold (Capnodium Sp.) Decrease Bloom And Fruit Number In ‘Natchez’ Crepe Myrtle (Lagerstroemia Xfauriei ‘Natchez’), Derald A. Harp, Beatriz Ruiz, Kara Bailey, Pedro Castillo, Phoebe Alvarez Mar 2026

Crepe Myrtle Bark Scale (Acanthococcus Lagerstroemiae) And Sooty Mold (Capnodium Sp.) Decrease Bloom And Fruit Number In ‘Natchez’ Crepe Myrtle (Lagerstroemia Xfauriei ‘Natchez’), Derald A. Harp, Beatriz Ruiz, Kara Bailey, Pedro Castillo, Phoebe Alvarez

Faculty Publications

Crepe myrtle bark scale (CMBS) (Acanthococcus lagerstroemiae) is an important pest of crepe myrtle in Texas, and infestations are accompanied by excessive growth of sooty mold (SM) that will cover stems, and, in severe cases, leaves. These combine to create significant stress on the plant, and anecdotal evidence suggests a decrease in bloom number under heavy infestation. In an existing planting of 24 ‘Natchez’ crepe myrtle in four blocks, three trees were randomly chosen in each block and treated with either a dinotefuran (year 1) or imidicloprid (year 2) drench. The three remaining trees were untreated. In February of year …


Black Medic (Medicago Lupulina) Identification And Control In Residential Landscapes, Michael Caron, Taun Beddes, Corey Ransom Mar 2026

Black Medic (Medicago Lupulina) Identification And Control In Residential Landscapes, Michael Caron, Taun Beddes, Corey Ransom

All Current Publications

Black medic (Medicago lupulina) is an herbaceous winter or summer annual broadleaf landscape weed. This fact sheet provides a weed description and describes suppression and control options.


Alternative Tree Species For Utah Syrup Production, Abigail Porter, Steven Price, Youping Sun, Darren Mcavoy Mar 2026

Alternative Tree Species For Utah Syrup Production, Abigail Porter, Steven Price, Youping Sun, Darren Mcavoy

All Current Publications

When thinking about producing syrup from trees, most people's minds go straight to maple trees. However, a variety of other species in the Intermountain West can be tapped for sap, including other maple species, birch, sycamore, aspen, and walnut. This fact sheet reviews alternative tree species for syrup production in Utah.


Ozone Pollution Reduction Partially Offsets The Negative Impact Of Climate Change Mitigation Efforts On Global Hunger, Shujuan Xia, Tomoko Hasegawa, Thanapat Jansakoo, Daniel Mason-D’Croz, Kazuaki Tsuchiya, Shinichiro Fujimori, Maksym Chepeliev, Marta Kozicka, Abhijeet Mishra, Willem-Jan Van Zeist, Xin Zhao, Thijs De Lange, Thais Diniz Oliveira, Jonathan C. Doelman, Matthew Gibson, Petr Havlík, Mario Herrero, Ipsita Kumar, Yuki Ochi, Timothy B. Sulser, Marina Sundiang, Kiyoshi Takahashi, Jun’Ya Takakura, Keith Wiebe Mar 2026

Ozone Pollution Reduction Partially Offsets The Negative Impact Of Climate Change Mitigation Efforts On Global Hunger, Shujuan Xia, Tomoko Hasegawa, Thanapat Jansakoo, Daniel Mason-D’Croz, Kazuaki Tsuchiya, Shinichiro Fujimori, Maksym Chepeliev, Marta Kozicka, Abhijeet Mishra, Willem-Jan Van Zeist, Xin Zhao, Thijs De Lange, Thais Diniz Oliveira, Jonathan C. Doelman, Matthew Gibson, Petr Havlík, Mario Herrero, Ipsita Kumar, Yuki Ochi, Timothy B. Sulser, Marina Sundiang, Kiyoshi Takahashi, Jun’Ya Takakura, Keith Wiebe

Department of Agricultural Economics Faculty Publications

Studies warning of the potential negative effects of climate mitigation on food security through the competing use of land for bioenergy and afforestation have overlooked the impact of reduced ozone and its potential enhancement of crop yields. Here we use six global agro-economic models to compare the impacts of climate change with climate mitigation policy and ozone reduction on agriculture. We find that ozone reduction could reduce the negative impact of a 1.5 °C-consistent climate change mitigation policy on global hunger by 15% in 2050. Sub-Saharan Africa and India, where hunger is most severe, account for 56% of this global …


Ifnγ-Induced Antigen Loss In Chimeric Antigen Receptor-T Cell Therapy, Miao Cao, Jasmine Alvarez, Ramkrishna Mitra, Michael Xu, Trevor R. Baybutt, Zhengyang Sun, Oluwatobiloba Taylor, Allison Doermann, Ross E Staudt, Scott A. Waldman, Adam E. Snook Mar 2026

Ifnγ-Induced Antigen Loss In Chimeric Antigen Receptor-T Cell Therapy, Miao Cao, Jasmine Alvarez, Ramkrishna Mitra, Michael Xu, Trevor R. Baybutt, Zhengyang Sun, Oluwatobiloba Taylor, Allison Doermann, Ross E Staudt, Scott A. Waldman, Adam E. Snook

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

INTRODUCTION: FDA-approved chimeric antigen receptor (CAR)-expressing T cell therapies (CARTs) have revolutionized the treatment of blood cancers. Yet none have been successful for "solid" tumors, such as colorectal cancer (CRC), the 2nd leading cause of cancer deaths. Guanylyl cyclase C (GUCY2C) has emerged as a clinical-stage target for CART and bispecific T-cell engager (BiTE) therapies in CRC. IFNγ has been canonically recognized as beneficial for the effector functions of T cells by enhancing antigen processing and HLA presentation and is essential for CART targeting of solid malignancies by inducing adhesion molecule expression for synapse stabilization.

METHODS: Using

RESULTS: We identified …


The Dual-Specificity Phosphatase Jsp1 Regulates Neutrophil Adhesion Via Integrin-Src Signaling In Vascular Inflammation, Li Li Mar 2026

The Dual-Specificity Phosphatase Jsp1 Regulates Neutrophil Adhesion Via Integrin-Src Signaling In Vascular Inflammation, Li Li

BCES: Faculty Publications

The c-JUN N-terminal kinase (JNK) signaling pathway plays an important role in regulating the innate immune response. Immune signaling is governed by the coordinated activity of protein kinases counter-balanced by protein phosphatases; however, the importance of the latter family of enzymes is less well understood. c-JUN N-terminal kinase (JNK)-stimulatory phosphatase 1 (JSP1, also known as DUSP22) has been implicated as a positive regulator of JNK signaling, yet its role in innate immunity is not clear. Using a mouse model of the local Shwartzman reaction, we show that JSP1 is essential for LPS-TNF-alpha-induced vascular injury. JSP1-knockout mice exhibited reduced vascular hemorrhage. …


Seeds Of Change - Building Community And Resilience With Plant Guilds, Roslynn Mccann, Liliane Dionne, Kevin White Mar 2026

Seeds Of Change - Building Community And Resilience With Plant Guilds, Roslynn Mccann, Liliane Dionne, Kevin White

All Current Publications

The goals of this Grade 6 living systems/biodiversity curriculum are to highlight Indigenous (First Nations, Métis, and Inuit) contributions to science, technology, and sustainable agriculture, with a focus on relational worldviews, permaculture practices, and respect for Mother Earth. Students will conduct plant experiments, learn Indigenous stories, make corn husk dolls, create a recipe, and enjoy eating their soup creation.


Cannibalism, Predation, And Refuges Of Juvenile Blue Crabsfrom A 37–Year Experiment, Anson H. Hines, Margaret A. Kramer, Kimberly D. Richie, L. David Smith, Robert Aguilar, Matthew B. Ogburn, Eric G. Johnson, Gregory M. Ruiz Mar 2026

Cannibalism, Predation, And Refuges Of Juvenile Blue Crabsfrom A 37–Year Experiment, Anson H. Hines, Margaret A. Kramer, Kimberly D. Richie, L. David Smith, Robert Aguilar, Matthew B. Ogburn, Eric G. Johnson, Gregory M. Ruiz

Biological Sciences: Faculty Publications

This 37-y record (1989–2025) of field experiments tested seasonal and annual variation in predation on juvenile blue crabs (Callinectes sapidus) in a representative mesohaline site of Chesapeake Bay, USA, where the species is a dominant epibenthic predator and major fishery. We used replicated sets of individually tethered crabs to provide a relative index of lethal and sublethal predation rates on intermolt individuals as a function of size and habitats. Cannibalism by large adult crabs accounted for>97% of predation of juvenile crabs; predation by fish was not observed; and mortality from physiological stress was rare (< 1%). Sampling by depth showed that juveniles occurred in nearshore shallows, while adults were in deeper water. Cannibalism was also depth-dependent: Rates were high at 75 cm depth; intermediate at 40cm; and lowest at 15 cm shallows, which provided partial refuge. Cannibalism was size-dependent: 30 to 50 mm juveniles experienced high rates of predation; 90 to 110mm preadults had low rates; and >120 mm adults …


Characterisation Of Pouch Secretions From Breeding Tasmanian Devils, Manujaya W. Jayamanna Mohottige, Emma Peel, Angéla Juhász, Mitchell G. Nye-Wood, Katherine Belov, Michelle L. Colgrave, Carolyn J. Hogg Mar 2026

Characterisation Of Pouch Secretions From Breeding Tasmanian Devils, Manujaya W. Jayamanna Mohottige, Emma Peel, Angéla Juhász, Mitchell G. Nye-Wood, Katherine Belov, Michelle L. Colgrave, Carolyn J. Hogg

Research outputs 2022 to 2026

Tasmanian devils (Sarcophilus harrisii), like all marsupials, give birth to altricial young. Here we employ proteomic analysis to identify components of devil pouch secretions that may contribute to offspring survival and development. Proteins were extracted from five samples and analysed by liquid chromatography-tandem mass spectrometry. Peptide-level evidence revealed proteins involved in a diverse set of immune pathways, including those mediating iron-ion transport, defence responses to bacteria, innate immune responses, and antigen processing. A core set of 200 proteins was identified across at least three samples, 63 of which were associated with antimicrobial or immunoregulatory functions. These included immunoglobulins, components of …


Radiation Doses To Cardiac Substructures Predict Elevation In High-Sensitivity Cardiac Troponin T Levels In Radiation Therapy For Lung Cancer, Xinru Chen, Xiaodong Zhang, Ting Xu, Radhe Mohan, Ruitao Lin, Mei Chen, Rachel C Maguire, Yao Zhao, Efstratios Koutroumpakis, Nicolas L Palaskas, Anita Deswal, Ali Ajdari, Joshua S Niedzielski, Sanjay S Shete, Laurence E Court, Jinzhong Yang, Zhongxing Liao Mar 2026

Radiation Doses To Cardiac Substructures Predict Elevation In High-Sensitivity Cardiac Troponin T Levels In Radiation Therapy For Lung Cancer, Xinru Chen, Xiaodong Zhang, Ting Xu, Radhe Mohan, Ruitao Lin, Mei Chen, Rachel C Maguire, Yao Zhao, Efstratios Koutroumpakis, Nicolas L Palaskas, Anita Deswal, Ali Ajdari, Joshua S Niedzielski, Sanjay S Shete, Laurence E Court, Jinzhong Yang, Zhongxing Liao

Faculty, Staff and Student Publications

Purpose: Cardiotoxicity is a major concern for patients undergoing thoracic radiation therapy. This study compared the predictive power of radiation dose-volume histogram (DVH) parameters and radiomic/dosiomic features of the whole heart (WH) and cardiac substructures for elevated circulating high-sensitivity cardiac troponin T (hs-cTnT), a biomarker for early detection of cardiac adverse events.

Methods and materials: A retrospective cohort of 160 patients with non-small cell lung cancer (NSCLC) from a completed prospective trial and a prospective cohort of 57 patients with NSCLC enrolled in an ongoing trial were analyzed. The endpoint was hs-cTnT elevation, indicated by an increase of ≥5 ng/L …


High Dietary Fiber Is Associated With Improved Outcomes In Patients With Melanoma And Sarcoma Treated With Immunotherapy Regardless Of Gut Microbiome Dysbiosis And Social Vulnerability, Brittany C Fields, Raymond S Traweek, Kai Jiang, Russell G Witt, Ashish Damania, Yi-Ju Chiang, Nadim Ajami, Elise Nassif-Haddad, Emily Z Keung, Manoj Chelvanambi, Xiaotao Zhang, Christine B Peterson, Jennifer A Wargo, Carrie R Daniel, Christina L Roland, Ashley M Holder Mar 2026

High Dietary Fiber Is Associated With Improved Outcomes In Patients With Melanoma And Sarcoma Treated With Immunotherapy Regardless Of Gut Microbiome Dysbiosis And Social Vulnerability, Brittany C Fields, Raymond S Traweek, Kai Jiang, Russell G Witt, Ashish Damania, Yi-Ju Chiang, Nadim Ajami, Elise Nassif-Haddad, Emily Z Keung, Manoj Chelvanambi, Xiaotao Zhang, Christine B Peterson, Jennifer A Wargo, Carrie R Daniel, Christina L Roland, Ashley M Holder

Faculty, Staff and Student Publications

Background: Social vulnerability, dietary fiber, and the gut microbiome have been individually implicated in clinical outcomes for melanoma and sarcoma patients. This study hypothesized that increasing social vulnerability is associated with insufficient dietary fiber intake and negatively associated with microbiome composition and clinical outcomes.

Methods: Clinicopathologic data, baseline fiber intake, and gut microbiome profiles were assessed in 153 patients with melanoma or sarcoma treated with immune checkpoint blockade (ICB) and prospectively followed. Patients' social vulnerability index (SVI) and fiber intake were evaluated for associations with microbiome composition, treatment response, and overall survival (OS).

Results: SVI percentile was 0.4 (interquartile ratio …


Simulated Hearing Loss In Healthy Young And Older Adults Results In Poor Reaction Time In Older Adults., Victoria Kowalewski, Nicoleta Bugnariu, Rita M. Patterson, Jessica Hartos Mar 2026

Simulated Hearing Loss In Healthy Young And Older Adults Results In Poor Reaction Time In Older Adults., Victoria Kowalewski, Nicoleta Bugnariu, Rita M. Patterson, Jessica Hartos

Pacific Journal of Health

Emerging evidence links hearing loss to increased fall risk in older adults, yet mechanisms remain unclear. This study examined the impact of simulated hearing loss on reactive balance control in healthy young and older adults. Participants performed dual-task scenario involving auditory sentence repetition and unexpected surface translations. Hearing loss was simulated using Adobe Audition, applying frequency-specific attenuation based on moderate sensorineural hearing loss levels from the literature.

Speech-in-noise performance significantly declined under simulated hearing loss for both age groups (p < .001), confirming effective simulation, but not significant differences were found between age groups. Maximum COP-COM displacement (the scalar distance between Center of Pressure and Center of Mass) increased with perturbation intensity (Level 1 vs. Level 2: p < .001), but no significant differences were found between hearing conditions or age groups (p > .05), suggesting compensatory step execution was preserved.

Reaction time analysis revealed a significant interaction between hearing condition and perturbation level …


Advancements In Extracellular Vesicle Research, Lucia R. Languino Mar 2026

Advancements In Extracellular Vesicle Research, Lucia R. Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The AAEV (American Association of Extracellular Vesicles) Annual Meeting at the John P. McGovern Commons in Houston, TX convened over 300 leading re- searchers, clinicians, and industry experts from around the world to advance the rapidly evolving field of extracellular vesicle (EV) science. EVs, nanoscale lipid- bound particles released by all prokaryotic and eukaryotic cells, have emerged as crucial mediators of intercellular communication, trans- porting proteins, nucleic acids, and lipids that influence a wide spectrum of physiological and pathological processes. Their involvement in immune modulation, tissue regeneration, cancer progression, metabolic regulation, and other complex biological functions positions EVs as promising …


Water Sources And Livelihood Choices Among Pastoralist Households In Monduli District, Tanzania, Fredrick Alleni Mfinanga, Jacqueline Temba, Monica F. Timbuka Mar 2026

Water Sources And Livelihood Choices Among Pastoralist Households In Monduli District, Tanzania, Fredrick Alleni Mfinanga, Jacqueline Temba, Monica F. Timbuka

Journal of Humanities and Social Sciences

This paper investigates the association between types of water sources for livestock and livelihood choices of pastoralist households in semi-arid areas of Monduli District, Tanzania. Specifically, it aims to examine the influence of the types of water sources for livestock on livelihood diversification of pastoralist households. Using a mixed research methods approach, the data were collected from 367 households through three methods: surveys, interviews, and focus group discussions. The quantitative data were analysed using descriptive statistics such as frequencies and counts, and inferential statistics, Chi-square tests and correlation, while the qualitative data were analysed using content analysis. The findings revealed …


The Nexus Between Perceived And Scientific Weather Patterns And Its Effects On Cereal Crop Production In Manyoni District, Tanzania, Fadhili Lufunyo Ngajilo, Helena Elias Myeya, Evarist Fundisha Swai Mar 2026

The Nexus Between Perceived And Scientific Weather Patterns And Its Effects On Cereal Crop Production In Manyoni District, Tanzania, Fadhili Lufunyo Ngajilo, Helena Elias Myeya, Evarist Fundisha Swai

Journal of Humanities and Social Sciences

This study examines the nexus between perceived and scientific weather patterns, and its effects on cereal crop production in Manyoni District; and involved 157 participants. Both quantitative and qualitative data were collected through a mixed methods research approach. The data were collected through a household survey, FGDs, in-depth interviews and documentary review methods for triangulation and complementarity purposes. The quantitative data were analysed through descriptive and inferential statistics with IBM SPSS (version 27) and Microsoft Excel Office (version 2007). The results indicate that smallholder farmers perceived that rainfall had been fluctuating with increasing trends, while temperature and wind had been …


Analysis Of Traditional Wisdom For Ecological Sustainability In Tanzania: A Case Study Of Metaphorical Source Domains In Pangwa Ritual Texts, Winne Stephen Mtega, Angelus Mnenuka Mar 2026

Analysis Of Traditional Wisdom For Ecological Sustainability In Tanzania: A Case Study Of Metaphorical Source Domains In Pangwa Ritual Texts, Winne Stephen Mtega, Angelus Mnenuka

Journal of Humanities and Social Sciences

Campaigns for ecological sustainability have gained a great currency in the contemporary academic discourse. Nonetheless, from time immemorial, Africans have pushed the ecological sustainability agenda through cultural taboos and regulated resource harvesting. Many African societies have embedded ecological consciousness in daily life expressions, and have intricately expressed it through literary and ritual texts. This study focuses on ecological awareness in the ritual texts of the Pangwa community. It analyses how environmental domains—such as land, seeds, and fruits—serve as the basis for metaphors in the Pangwa community to prove the use of wisdom to promote and sustain ecological practices (ecocriticism). The …


Larvicidal Activity Of Β-Asarone And Acorus Calamus Linn. (Sweet Flag) Extract Against Aedes Aegypti (Dipotera: Culicidae): Enzyme Inhibition, Midgut Histopathology, And In Silico Analysis, Rizal Subahar, Surya Dwira Mar 2026

Larvicidal Activity Of Β-Asarone And Acorus Calamus Linn. (Sweet Flag) Extract Against Aedes Aegypti (Dipotera: Culicidae): Enzyme Inhibition, Midgut Histopathology, And In Silico Analysis, Rizal Subahar, Surya Dwira

Indonesian Journal of Medical Chemistry and Bioinformatics

Aedes aegypti (Diptera: Culicidae), the primary vector of dengue, poses a significant public health threat in tropical and subtropical regions. Botanical insecticides and phytochemicals such as β- asarone, derived from essential oils,offer a promising alternative to synthetic larvicides. The rhizome of Acorus calamus L. (sweet flag), traditionally known for its neuroprotective and antioxidant properties, contains β-asarone as its principal bioactive constituent.This study evaluated the larvicidal efficacy of β-asarone and A. calamus rhizome extract against Ae. aegypti larvae, focusing on detoxification enzyme inhibition, midgut histopathology, and in silico molecular interactions.Third- and fourth-instar larvae were exposed to β-asarone and crude extract at …


The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al. Mar 2026

The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al.

Faculty Publications

Open data and code are crucial to increasing transparency and reproducibility, and in building trust in scientific research. However, despite an increasing number of journals in ecology and evolutionary biology mandating for data and code to be archived alongside published articles, the amount and quality of archived data and code, and subsequent reproducibility of results, has remained worryingly low. As a result, a handful of journals have recruited dedicated data editors, whose role is to help authors increase the overall quality of archived data and code. There is, however, a general lack of consensus around what a data editor should …