Digital Commons Network^™

Transcriptome Profiling Of Silique Lncrnas Reveals Novel Insights Into Silique Length In Radish (Raphanus Sativus L.), Xiaomin Yu, Yuxin Zhu, Zhoubo Guan, Shisheng Li

Turkish Journal of Botany

Radish is a widely cultivated vegetable with known medicinal value and produces siliques that differ significantly in number and size. The present study compares normal Duanye-13 radish (CK-type) siliques with mutant radish siliques induced by chemical mutagenesis at the young (YS), short (SS), and long (LS) silique stages. Differences in long noncoding ribonucleic acid (lncRNA) expression were investigated using high-throughput RNA sequencing and bioinformatic analyses, revealing 45 324 new lncRNAs in radish siliques. lncRNA expression was higher in YS and LS mutant lines than in CK-type lines, and expression in SS mutants tended to be lower than in CK-type lines. …

Genome-Wide Crispr Screen Identifies A Cytokine-Enhancer Circuit Driving Hif-2Α Activation In Renal Cancer, Jun Fang, Jeremy M Simon, Tao Wang, Yunpeng Gao, Xianju Bi, Lianxin Hu, Chengheng Liao, Cheng Zhang, Yayoi Adachi, Jin Zhou, Hongyi Liu, Qian Liang, James A Nathan, Ram Mani, James Brugarolas, Qing Zhang

Faculty, Staff and Student Publications

Resistance to HIF-2α inhibitors such as Belzutifan underscores the need to better understand how HIF-2α is transcriptionally regulated in clear cell renal cell carcinoma (ccRCC). Here, we uncover a cytokine-driven enhancer mechanism that sustains HIF-2α expression through the JAK1-STAT3 signaling pathway. Using a genome-wide CRISPR screen in VHL-deficient ccRCC cells, we identified SOCS3 as a key negative regulator of HIF-2α. Mechanistically, loss of SOCS3 activates JAK1-STAT3 signaling, leading to the recruitment of STAT3 to distal enhancers upstream of EPAS1 that physically loop to its promoter to drive HIF-2α transcription. This cytokine-enhancer circuit was recapitulated in ccRCC patient samples and functionally …

Design Of Experiments Based Reversed-Phase High-Performance Liquid Chromatography Method For Estimation Of Metformin And Glimepiride In Combined Dosage Forms, Neela Manish Bhatia, Rachana Patil, Harinath More, Rutuja Dattatray Chougale

The Thai Journal of Pharmaceutical Sciences

Background: The present study aimed to systematically develop and validate a robust, rapid, and stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of metformin and glimepiride in fixeddose combination tablets. Method development was guided by a design of experiments (DoE) approach using the Box-Behnken design (BBD) to ensure optimal analytical performance.
Materials and Methods: Chromatographic separation was achieved on a Cosmosil C18 column using an optimized mobile phase of acetonitrile and water (80:20, v/v) adjusted to pH 3.5. The flow rate was 1 mL/min, and detection was performed at 221 nm. The BBD approach systematically evaluated the …

Best Integrated Writing Spring 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Tlr3 Mediated Type I Interferon Response In Mammalian Cell Defense Against Cryptosporidium Parvum Infection., Anjelica Matias

Biochemistry and Molecular Biology

Cryptosporidium parvum is a major cause of a diarrheal disease which affects many children in the USA as well as the rest of the world, yet the contribution of its double stranded RNA (dsRNA) viral symbiont, Cryspovirus (CSpV1) to host innate immunity remains unclear. This study investigated whether CSpV1 activates Toll Like Receptor 3 (TLR3) signaling pathways and downstream Interferon type I (IFN I) responses in mammalian intestinal epithelial cells. Confluent Human Ileocecal Colorectal Adenocarcinoma cells (HCT8) were exposed to CSpV1, and the expression levels of Tumor Necrosis Factor Receptor-Associated Factor 3 (TRAF3), Nuclear Factor-𝜅-light chain enhancer of activated B-cells …

Bacteriophage Therapy For Antibiotic-Resistant Infections, Shiva Pariyar

Best Integrated Writing

Pariyar examines bacteriophage therapy as a promising alternative to antibiotics for treating multidrug-resistant infections, highlighting its targeted mechanism, ability to disrupt biofilms, and synergy with antibiotics. While challenges such as regulation, immune response, and limited clinical trials remain, the study argues that advances in biotechnology and global collaboration position phage therapy as a future cornerstone in combating antimicrobial resistance.

Associations Between Reported Use Of Nutritional Labels And Calorie Intake In Us Adults: Findings From Nhanes 2017–2020, Ariana M. Chao, Nancy Greene, Alexandra Paul, Paule V. Joseph

College of Nursing Faculty Papers & Presentations

Objective: Caloric information is commonly displayed on nutritional fact labels and food menus. Yet evidence is limited on whether label use is associated with a reduced-calorie diet. This study examined the associations between the use of caloric information on nutritional facts and menu labels and daily caloric intake. Methods: We used data from adults in the National Health and Nutrition Examination Survey (NHANES) 2017–2020 to conduct a cross-sectional study. Calorie label use on nutritional labels and menus was assessed using the Flexible Consumer Behavior Survey telephone interview. Caloric intake was evaluated using the mean of two 24-h diet recalls implemented …

Key Elements Of Mission-Based Urban Agriculture In The United States Aimed At Addressing The Social Determinants Of Health, Jordan Losavio

LSU Doctoral Dissertations

Urban agriculture (UA) in the United States (U.S.) is increasingly positioned as a multi-domain strategy for addressing social determinants of health (SDOH), yet evidence is fragmented and often focused on participant outcomes rather than the organizational and environmental conditions that determine whether those benefits can be sustained, expanded, or maintained over time. This dissertation uses an exploratory sequential mixed-methods design to clarify (1) what SDOH outcomes are associated with UA in the peer-reviewed literature, (2) which internal and external factors leaders perceive as driving UA organizational success or failure, and (3) which factors predict comparative organizational functioning across a national …

Aquifer Characteristics And Groundwater Flow Modeling For Sustainable Water Resources Development And Planning Using Modflow Software In India, Ravi Sharma

AUIQ Complementary Biological System

MODFLOW is one of the most commonly used numerical models for simulating groundwater flow. Its structured data design and compatibility with GIS tools make it suitable for groundwater assessment and planning. Groundwater forms an important part of the hydrological cycle and occurs within the pore spaces of sedimentary rocks or within fractures in hard rock terrains. Although its distribution beneath the surface is not always uniform or predictable, it is still considered one of the cleanest, most accessible, and quickly available freshwater sources. Numerical groundwater models help convert complex subsurface processes into simplified relationships that describe flow behavior. Even though …

Pull Factors Of College Selection: The Role Of Club Sports In Student Enrollment Decisions, Brett A. Anderson, Sean Seiler, Thomas Baker

Journal of Issues in Intercollegiate Athletics

The relationship between club sports in intercollegiate athletics and their influence on student recruitment and retention remains underexplored within the broader participatory sport ecosystem. Guided by push–pull models of college selection, this study examines whether the availability of club sports functions as a meaningful pull factor in students’ decisions to enroll in and remain at an institution. Survey data were collected from 151 current undergraduate and graduate club sport athletes across the United States. Exploratory factor analysis identified a distinct Club Sports factor, demonstrating strong construct validity and internal consistency. Multiple regression analyses revealed that club sport availability was a …

The Impact Of Michi-No-Eki (Roadside Stations) On The Regional Economy: An Input–Output Analysis Of Minamiboso City In Chiba Prefecture, Ryusaku Matsuo, Takeru Aizawa, Gon Jan, Wei Yuanxin, Masaharu Uchiyama, Gento Tagami

Japanese Society and Culture

This study quantitatively examines the economic impact of Michi-no-Eki (Roadside Stations) in Minamiboso City, Chiba Prefecture, using an input–output analysis based on the Chiba Prefectural Interindustry Table. Eight Michi-no-Eki were evaluated in terms of direct, indirect, and induced effects, including employment creation. The results show that the total production-inducing effect generated by the stations amounts to ¥7.02 billion per year, and the employment-inducing effect reaches 108.7 persons annually, indicating that Michi-no-Eki function as a central engine of the local economy. Moreover, thematic diversity among stations—such as loquat, flowers, and seafood—enhances multiplier effects through inter-sectoral linkages. These findings demonstrate that Michi-no-Eki …

Fenced And Feral: Farming And Spread Of Flowerhorn (Amphilophus Spp.) In Lake Sampaloc, Philippines, Janice A. Ragaza, Hannah Nicole Gasmen

Environmental Sustainability

This study examines the spread and ecological impact of invasive Flowerhorn cichlids (Amphilophus spp.) in Lake Sampaloc, Philippines, driven by both accidental release and intentional aquaculture practices. Field observations and literature reveal that these highly adaptable and aggressive fish outcompete native species, contributing to biodiversity decline amid increasing pollution, eutrophication, and microplastic contamination. Their phenotypic plasticity allows them to thrive in degraded environments, further exacerbating ecological imbalance. While local communities have begun utilizing Flowerhorns for ornamental trade and potential aquafeed production, such practices risk reinforcing their proliferation. The study highlights the need for integrated management strategies combining biosecurity, pollution control, …

Research Progress On Economic Impact Of Animal Diseases, Zhen Xu, Haizhao Zhang, Zizhong Shi, Hui Zhou, Xiangdong Hu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Animal diseases not only pose significant challenges to the stable development of related industries such as livestock farming but also adversely affect the broader economic and social landscape. This paper presents the reviews on the current state of research both domestically and internationally, systematically presenting the advancements of the economic impacts of animal diseases. The findings reveal that, (1) the economic impacts of animal diseases can be categorized into direct and indirect effects; however, a unified analytical framework has yet to be established. The “Epidemiology-Economics” approach is the primary analytical method for assessing the economic impacts of animal diseases. (2) …

Heavy Metal Contamination In Agricultural Soils And Potential Human Health Risks, Debora Michael Mwenda, Leonard Masesa Jumanne, Daudi Salvius Mgaya, Amos Vincent Ntarisa

Tanzania Journal of Science

Heavy metal contamination in agricultural soils is a growing concern due to potential human health risks via ingestion, dermal contact, and inhalation. However, data on fertiliser-related contamination in rural Tanzanian settings remain limited. This study assessed contamination levels and associated health risks in Kibwabwa village, Iringa, Tanzania. A total of 48 soil samples were collected from eight farms at a depth of 0–15 cm. Concentrations of Cu, Zn, Ni, Cd, Cr, and Pb were determined using Atomic Absorption Spectroscopy (AAS). Health risks were evaluated using chronic daily intake (CDI), hazard quotient (HQ), hazard index (HI), and carcinogenic risk (CR) models …

Antibacterial Activity Of Sapium Ellipticum, Securidaca Longepedunculata, And Allophylus Africanus Against Drug-Resistant Pseudomonas Aeruginosa Isolates, Eleonora A. Mbare, Rose J. Masalu, Cyprian B. Mpinda

Tanzania Journal of Science

Pseudomonas aeruginosa poses a major clinical challenge due to its high levels of antibiotic resistance. This study evaluated the antibacterial activity of three medicinal plant extracts Allophylus africanus (leaves), Securidaca longepedunculata (root bark), and Sapium ellipticum (stem bark), against 30 drug-resistant P. aeruginosa isolates. Antibacterial screening was conducted using the agar well diffusion method, followed by determination of minimum inhibitory concentrations (MICs) via a 96-well microtiter plate assay. All three plant extracts demonstrated inhibitory activity against three resistant P. aeruginosa strains (gentamicin-resistant strains F4 and GR4RAU-AI, and ceftazidime-resistant strain 19-10), with inhibition zones of varying diameters. MIC values showed strain-specific …

Construction Of Emerging Contaminants Risk Governance System, Cheng Li, Mingcheng Wang, Chunlei Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Emerging contaminants pose considerable risks to the ecological environment, human health, and social safety. The establishment of an emerging contaminants risk governance system constitutes a crucial component of the national ecological security strategy and the ecological civilization framework in the new era. When examined through the lens of the holistic view of national security and guided by the ecological civilization philosophy of the new era, China’s current efforts in managing emerging contaminants reveal several shortcomings—including a fragmented and incomplete risk management system, as well as preliminary stages in chemical environmental management policies and related technologies. Therefore, grounded in national conditions …

Audubon Society Minutes, W.A. Ginham

Documents

Minutes of the Audubon Society--October 7, 1931, in Wesleyan Hall. The second part of the meeting was noted on November 4, 1931.

Immunoregulatory Effects Of Choerospondias Axillaris (Roxb.) B.L.Burtt & A.W.Hill Fruit Extract In Mice With Insights On In Vitro Mechanism, Ravi Gautam, Anju Maharjan, Jaehee Lee, Sujeong Yang, Jihun Jo, Manju Acharya, Daeun Lee, Narayan Prasad Ghimire, Saroj Lamichhane, Byungsun Min, Changyul Kim, Hyoungah Kim, Yong Heo

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: Lapsi (Choerospondias axillaris), a plant native to Nepal, has been traditionally used in Asian countries to treat cardiovascular conditions. However, its effects on immune regulatory function remain largely unexplored. This study aimed to in vivo evaluate the immunoregulatory properties of Lapsi fruit extract in mice on immunotoxic responses with analysis on in vitro mechanism for immune suppression, oxidative stress, and inflammatory response. Male Balb/c mice were intragastrically administered various doses of the extract for 21 days. In some mice, immune suppression was induced with cyclophosphamide, and subsequent immune recovery was assessed. In addition, RAW264.7 cells and THP-1-derived macrophages were …

Louisiana Species Of The Genus Xestia Hübner And The Genus Agnorisma Lafontaine, Vernon Antoine Brou Jr., Charlotte Dozar Brou

The Taxonomic Report of the International Lepidoptera Survey

We address three species of the genus Xestia Hübner recorded for the state of Louisiana: Xestia dilucida (Morrison), Xestia elimata (Guenée) and Xestia c-nigrum (Linnaeus), and we also address new state capture records for Agnorisma badinodis (Grote) and Agnorisma bollii in Louisiana.

Sustainable Guiding Framework Of The Egyptian Rural Development Initiative (Hayah Karima), Eman Badawy Ahmed

Mansoura Engineering Journal

The Hayah Karima initiative launches to improve the standard of living for the most needy community groups across the Egyptian countryside, and it also contributes to improving the quality of services provided to the neediest villages. The research aims to propose a guiding framework for sustainability in villages of the Hayah Karima Initiative to achieve Egypt’s Sustainable Vision 2030. To achieve the goal, the research will study the goals, strategies, and principles of the Hayah Karima Initiative, the Egypt Vision 2030, COP 27, the sustainability evaluation criteria, and the Green Villages Initiative. Consequentially, in addition to A questionnaire to measure …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Nonnative Crayfish In Türkiye: Presence Records, Invasion Pathways, And Ecological Risks, Muzaffer Mustafa Harlioğlu

Turkish Journal of Zoology

The globalization of trade, aquaculture, and the ornamental pet industry has accelerated the transboundary movement of nonnative crayfish species, with significant ecological consequences. Türkiye, a biodiversity-rich country bridging Europe and Asia, has increasingly become a point of concern due to the rising presence of alien crayfish taxa introduced primarily via the aquarium trade and scientific research. This study investigates the presence records of nonnative crayfish species in Türkiye, identifies their likely introduction pathways, and outlines potential future outspread routes across the major freshwater basins of the country. Species such as Procambarus clarkii, Cherax quadricarinatus, C. albertisii, and Cambarellus patzcuarensis have …

Stage-Specific Growth Characteristics Of The Calanoid Copepod Invader Sinodiaptomus Sarsi​, Leonid Svetlichny, Kami̇l Mert Eryalçin, Melek İşi̇ni̇bi̇li̇r Okyar

Turkish Journal of Zoology

The population dynamics of the Asian invasive copepod Sinodiaptomus sarsi were  studied for four years after its introduction into an artificial pond in Kyiv (Ukraine) in  2020. The growth and development parameters of this species were measured under  laboratory conditions. From its first appearance in spring 2020, the abundance  of copepodite stages and adults increased from 3.5–5.2 individuals (ind.)  m–3 to 1057.8 ind. m–3 in June 2024, suggesting the successful establishment  of S. sarsi populations in this region. A characteristic feature of S.  sarsi development in ponds is a male-biased sex ratio in the later copepodite stages.  The sex ratio …

Morphometric And Reproductive Divergence Of Deep-Water Shrimps Plesionika Martia (A. Milne-Edwards, 1883) And P. Heterocarpus (A. Costa, 1871) Along A Depth Gradient In The Eastern Aegean Sea, Murat Özbek, Cengi̇z Koçak, Zafer Tosunoğlu

Turkish Journal of Zoology

This study provides a comparative analysis of two deep-water pandalid shrimp  species, Plesionika martia and P. heterocarpus, based on monthly samples collected  over one year in the Eastern Aegean Sea. Specimens were obtained from species-specific depth zones (550 m for P. martia and 350 m for P. heterocarpus) to examine  morphometric traits, sexual dimorphism, and reproductive patterns. A total of 4419  individuals were analyzed. Females were significantly larger and more abundant than  males (K–S test, p < 0.05), indicating pronounced sexual dimorphism. Length–weight relationships revealed negative allometric growth in both species, confirmed  by t-tests (p < 0.05). Reproductive activity differed markedly: P. martia showed a short  and distinct spawning period peaking in late autumn, whereas P. heterocarpus  displayed a prolonged, bimodal cycle with peaks in spring and summer. The gonadosomatic index (GSI) and the proportion of ovigerous females varied  significantly by season and species. A strong positive correlation between carapace  length and gonad weight was found, with a more linear relationship in P. martia and  greater variability in P. heterocarpus. Size at first maturity (L₅₀) was estimated at 22.3  mm CL for P. heterocarpus but could not be reliably determined for P. martia  due to limited small size data, likely reflecting ontogenetic depth segregation. The  consistent bathymetric separation between these species—also reported in the  Western Mediterranean—suggests ecological niche differentiation. Species-specific  management measures, including depth-based fishing restrictions and temporal  closures during reproductive peaks, are recommended to support the sustainable  exploitation of deep sea shrimp stocks in the region.

Frequencies And Roles Of Plants In The Diet Of Three Mesocarnivores (Canis Lupaster, Genetta Genetta, And Herpestes Ichneumon): Implications For Forest Regeneration In A North African Hot Spot (Algeria), Messaoud Bensidhoum, Abdelkrim Limane, Larbi Khifer, Ania Ben Ammar, Lylia Amrouche

Turkish Journal of Zoology

The Djurdjura National Park (PND, Algeria) is part of one of the world’s 36 biodiversity hot spots, recognised by the United Nations as a national biosphere  reserve. It contains the Darna primary forest, a key habitat for several mesocarnivore  mammals, including the golden wolf (Canis lupaster), the common genet (Genetta  genetta) and the ichneumon mongoose (Herpestes ichneumon). Although their diets  are primarily based on animal prey, these carnivores exhibit both qualitative and  quantitative reliance on plants, a pattern that merits thorough documentation. We  analysed 30 scats per species per month over four years (1440 scats per species).  More than 35% …

Species Identification Using Otolith Morphometry Of Four Gurnards (Family: Triglidae) From  Edremit Bay (Aegean Sea), Ahmet Mert Şenbahar, Di̇lek İlhan, Aydin Ünlüoğlu, Sencer Akalin

Turkish Journal of Zoology

Shape and size analyses of otoliths are widely considered appropriate tools for distinguishing between fish species and for assessing populations and stocks.  The present study aims to distinguish four gurnard species collected from Edremit  Bay (Aegean Sea) based on variations in their otolith shape morphology. A total of 60  specimens of Eutrigla gurnardus, 64 of Chelidonichthys lastoviza, 60 of  Chelidonichthys lucerna, and 60 of Lepidotrigla cavillone were analyzed. No  significant intraspecific differences were noted in the morphology of the left and right  otoliths, and so only the left sagittal otoliths were subjected to further analysis. Otolith  shape was quantified using …

Western Conifer Seed Bug (Leptoglossus Occidentalis), Emilie Demard

All Current Publications

This fact sheet provides information on the western conifer seed bug, including native range, life cycle, plant hosts, symptoms and damage, and management options.

Latest Sightings Of The Striped Hyena In North Africa: Major Threats And Conservation Actions, Abderrazak El Alami, Abderrazzak Fattah, Ilyas El Alami, Ziad El Alami

Turkish Journal of Zoology

The striped hyena (Hyaena hyaena) is widely distributed across the northern half of Africa, the Middle East, the Arabian Peninsula, and parts of Asia. However,  numerous studies indicate that this carnivore is in decline, and it is currently classified  as near threatened on the IUCN Red List of threatened species. In North  Africa, the Hyaena hyaena barbara subspecies has been extirpated from many  areas. This article summarizes data collected from observations of the striped hyena  in North Africa between 2004 and 2024. Among the 418 striped hyenas recorded in  North Africa between 2004 and 2024, 18.4% (n = 77) were …

Culvert Retrofit With Green Filter Media For The Removal Of Phosphorus From Stormwater Runoff, Somdipta Bagchi, Zhiming Zhang, Olayinka Olayiwola, Bharadwaj Mandala, Rupali Datta, Subhasis Giri, Richard Lathrop, Dibyendu Sarkar

Michigan Tech Publications

Phosphorus is a ubiquitous contaminant in urban and agricultural landscapes. A retention basin located in the southern part of Barnegat Bay, New Jersey, was identified as receiving stormwater runoff with elevated phosphorus concentrations. The basin is surrounded by expanding urban development, contributing to the progressive degradation of water quality in the bay, which is already highly eutrophic. This study evaluated the effectiveness of a culvert retrofit with a green filter media composed of granulated-aluminum-based drinking water-treatment residuals (Al-WTR) and granular carbon (5:1 ratio, w/w) for the removal of phosphorus and suspended sediments from stormwater runoff. The performance of the filter …

Genetic Variants And Molecular Components Associated With Metabolic Dysfunctional-Associated Steatotic Liver Disease And Depression: Shared Association Of Adamts7 And Thrap3, Eron G. Manusov, Vincent P. Diego, Marcio A. Almeida, Jacob A. Galan, Kathryn Herklotz, Edwardo Abrego Ii, Habiba Sultana, Luis A. Peña Marquez, Marco Arriaga, Marcelo Leandro, Juan M. Peralta, Ana C. Leandro, Tom Howard, Joanne Curran, Sandra Laston, John Blangero, Sarah Williams-Blangero

Human Genetics Publications

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and depression frequently occur together. Identifying the genes that influence both MASLD and depression may facilitate the discovery of biological pathways associated with disease risk.

Methods: We recruited 525 participants from Mexican American families living in the Rio Grande Valley of south Texas. We collected clinical data, biometric measurements, hepatic health assessments using Vibration-Controlled Transient Elastography (VCTE), and depression evaluations determined with the Beck Depression Inventory-II. We estimated the heritability (h2) of MASLD-related measures, depression status, aspartate aminotransferase (AST), alanine aminotransferase (ALT), the AST/ALT ratio, and Vibration-Controlled Transient Elastography measurements. For each gene, …