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Rapid Whole Genome Sequencing Uncovers A Triple Diagnosis: X-Linked Chondrodysplasia Punctata, Mecp2-Related Disorder, And Mosaic Jacobs Syndrome, Megan Samuels, Kathleen Shields, Paul Hillman, Laura Farach

Faculty, Staff and Student Publications

Background: Rapid Whole Genome Sequencing (rWGS) is increasingly being used in neonatal intensive care units, as there is growing evidence that rare singe gene disorders present in the neonatal period and early identification can change management. While the diagnostic utility is increased with this broad testing, the possibility of unexpected findings also increases significantly. Here, we present a patient found to have three distinct genetic conditions through rWGS testing, with significant psychosocial and health consequences.

Methods and results: This case report describes a patient who was identified with a form of chondrodysplasia punctata, as well as incidental findings of MECP2-related …

Association Between Maternal Stress And Child Sleep Quality: A Nationwide Echo Prospective Cohort Study, Sarah Dee Geiger, Aruna Chandran, Marie L Churchill, Maxwell Mansolf, Cai Zhang, Salma Musaad, Courtney K Blackwell, Stephanie M Eick, Dana E Goin, Susan Korrick, Akram Alshawabkeh, Patricia A Brennan, Carrie V Breton, Jose F Cordero, Sean Deoni, Viren D'Sa, Anne L Dunlop, Amy J Elliott, Assiamira Ferrara, Arlene Keddie, Monique Lebourgeois, Kaja Z Lewinn, Daphne Koinis-Mitchell, Maristella Lucchini, Sara S Nozadi, Thomas O'Connor, Yeyi Zhu, Emily Zimmerman, Susan L Schantz

Children’s Nutrition Research Center Staff Publications

Background: Childhood sleep quality is associated with physical, cognitive, and behavioral health and predicts later sleep quality; it has many determinants, including developmental exposures.

Objectives: To examine associations between maternal stress during pregnancy and childhood sleep quality and determine whether postnatal stress mediates the association.

Method: Data from the Environmental Influences on Child Health Outcomes cohort were used. Perceived Stress Scale (PSS) T-scores were the exposure measure. Outcome measures were preschool Child Behavior Checklist (CBCL) sleep syndrome scale and Patient-Reported Outcomes Measurement Information System Sleep Disturbance Parent Proxy short form 4a (PSD4a) T-scores at ages 4-8 years. Linear mixed-effects regression …

Category Learning Reorganizes Internal Representations Of Visual Artworks, Aishwarya Gurung

Dissertations, Theses, and Capstone Projects

How are categories of art internally represented, and how can we capture those representations systematically? Investigating category learning in the context of complex, multidimensional stimuli like visual artworks presents unique challenges due to their inherent variability and perceptual complexity. Artworks engage multiple cognitive processes and are shaped by both sensory-driven mechanisms and top-down influences like prior knowledge, making them uniquely suited for studying how structured categorical knowledge interacts with perceptual and aesthetic judgments. The present study addresses these questions by utilizing machine-learning tools to construct and implement a two-dimensional similarity space of 400 existing artworks painted by two artists from …

The Psychophysiology Of Primary And Secondary Variants Of Psychopathic Traits In Youth, Ines Guariguata

Dissertations, Theses, and Capstone Projects

Psychopathy is a cluster of personality traits marked by a pervasive callousness, lack of shame or remorse, deceitfulness, a persona of confidence and charm, shallow emotional connection, general lack of insight into their actions, and an absence of anxiety (Glenn & Raine, 2014; Hare, 2003). Research suggests that there are distinct etiological pathways to the development of psychopathic traits and that their responses to treatment are different (Craig et al., 2021; Yildrim & Derksen, 2015; Fleming et al., 2023). Primary variants show a low-fear, low-anxiety profile during stress, and have a genetic basis (Craig et al., 2021; Yildrim & Derksen, …

Vertex-Based Analysis Of Cerebral Blood Flow And Fractional Amplitude Of Low-Frequency Fluctuations (Cbf-Falff) Coupling In Moderate-To-Severe Traumatic Brain Injury During The First Year Post-Injury, Vaidehi Hemkumar Patel

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) is known to involve damage in the neurovascular unit. TBI may disrupt the brain’s neurovascular coupling–the relationship between cerebral blood flow and neural activity–that can lead to cognitive and functional impairments. This study attempted to non-invasively investigate neurovascular coupling in patients with moderate to severe TBI (msTBI) during the first year post-injury using a combined metric of cerebral blood flow (CBF) and fractional amplitude of low-frequency fluctuations (fALFF), a proxy for spontaneous neural activity. Using arterial spin labeling (ASL) and functional MRI sequences, CBF and fALFF were measured in 29 msTBI patients 3-, 6- and 12-months …

An Erp Study Of Attentional Blink And Inhibition Of Return, Caesar Ekya

Dissertations, Theses, and Capstone Projects

Attention can be allocated over time and space and it has long been speculated whether these are a part of the same or different attentional mechanisms. Attentional Blink (AB) and Inhibition of Return (IOR) are cognitive phenomena that are used in experimental settings to study temporal attention (AB) and spatial attention (IOR) respectively. Though known for being representative of different types of attention, they nevertheless display similar characteristics, making them intriguing choices to study the interplay between temporal and spatial attention. For this study we chose a dual-stream rsvp paradigm that would elicit both AB and IOR within the same …

Constructing A Parameterized Stimuli Space Suitable To Induce Controlled Changes In Human And Machine Perceptual Systems, Andrew Frankel

Dissertations, Theses, and Capstone Projects

Traditional computer vision applications focus on objective tasks, such as object detection, classification, or segmentation. Much of human experience is inherently subjective, such as our personal response to artwork. Individualized experiences are challenging to replicate in a controlled laboratory environment, as those experiences depend on the unique history and internal models of the observer. This work presents a technique to construct a 2-dimensional parameterized stimuli space suitable to induce controlled changes in the perceptual systems of both human and machine observers. Our contributions are threefold:

1. Using a balanced dataset of 8,800 fine art images spanning 11 art movements and 88 …

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Quantified Lives: Data, Bias, And The Cost Of Categorization, Colin F. Geraghty

Dissertations, Theses, and Capstone Projects

This project critically examines how statistical methods and data visualization have historically been used to categorize, rank, and control human populations. By exploring the works of key figures like Francis Galton, Karl Pearson, and R.A. Fisher, it traces the evolution of categorization frameworks from their eugenic roots to modern applications in artificial intelligence and global metrics like the World Happiness Report. Through interactive visualizations and historical analysis, the project invites users to question the legitimacy of these frameworks and reflect on their impact on society. At its core, this work emphasizes the need to move beyond rigid classification systems, challenging …

Prevalence Of Exercise Dependence Among High-Intensity Functional Training Practitioners: A Cross-Sectional Analysis, Beatriz E O M R P Da Silva, Marcio Boniatti

International Journal of Exercise Science

International Journal of Exercise Science 18(4): 206-214, 2025. The objective was to explore the prevalence of exercise dependence (ED) risk among regular HIFT exercisers. Secondary objectives include exploring the prevalence of injuries within this population and examining the potential association between ED risk and injury prevalence. This cross-sectional study was conducted in a city in southern Brazil and included HIFT practitioners. ED was evaluated using the Exercise Dependence Scale-Revised (EDS-R). The primary outcome was the prevalence of ED risk. The final analysis included 64 HIFT practitioners, of whom the majority were female (n = 35; 54.7%). The mean EDS-R …

Torso Of A ‘Weary Heracles’ Marble Statuette From Ḥorbat Ṭarbenet (Pp. 167–177), Gabriel Mazor, Walid Atrash

'Atiqot

A statuette of a free-standing naked male figure of Heracles was discovered in a fill partially covering a village bath at Ḥorbat Ṭarbenet. The appearance of Heracles in Roman baths is witnessed elsewhere in the region, forming part of the bath décor and usually set in niches in the frigidarium walls, the palestra, or the natatio. A statuette of Heracles in a bathhouse, although not an exceptional Hellenic cultural expression, is a rather unique find in a remote (Jewish?) village.

Comparing 17Β-Estradiol And Progesterone Concentrations In Young, Physically Active Females: Insights From Plasma Versus Serum Analysis, Samantha N. Rowland, Mariasole Da Boit, Rachel Tan, Liam M. Heaney, Stephen J. Bailey

All Faculty Open Access Publications

Serum measurements of 17β-estradiol and progesterone are widely used to verify menstrual cycle status and confirm contraceptive use, often through commercially available immunoassay kits. However, no studies have investigated whether blood collection tube chemistries influence hormone concentrations in young females, despite assays permitting the use of different biofluids with similar reference ranges. In this study, venous blood was sampled from physically active females (n = 25) using Ethylenediaminetetraacetic acid (EDTA) and serum vacutainers, and 17β-estradiol and progesterone concentrations were measured using competitive immunoenzymatic assays. Median plasma concentrations of 17β-estradiol and progesterone were 44.2% (plasma 40.75 vs. serum 28.25 pg/ml) and …

Cultural Capital Skill Development In Undergraduate Kinesiology Curriculum, Jenica Alvarez, Sabrina R. Fordham, Elizabeth M. Harrison, Blake Podsen, Jason C. Casey, Rich Pruett

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 2, 2025. Specialization within Kinesiology and related fields over the past 20 years has led to the prioritization of technical skill development. This specialization leaves limited availability of resources for the development of Cultural Capital (CC) skills in undergraduate kinesiology and kinesiology-related curricula. The purpose of this study was to examine how seven Experiential Learning Activities (ELAs) influence CC skill development in an undergraduate kinesiology practicum course. An interpretive qualitative action research design was applied to investigate five senior undergraduate kinesiology students’ experiences. The study concluded: (a) six of …

A Linear Periodized Resistance Training Program Is Effective At Reducing Depressive Symptoms But Not Anxiety In Females: A Pilot, Jason Sawyer, Matthew Mcpherson, Meghan Reuter, Paul A. Cacolice

Biological and Biomedical Sciences Department Faculty Journal Articles

The purpose of this study was to determine whether a periodized resistance training program would influence self-reported depression and anxiety scores in college-aged females. Methods: Eight participants participated in a six-week periodized resistance training program. The participants completed a 3–5 repetition maximum (3–5 RM) for the sumo deadlift (SDL), bench press (BP), barbell back squat (BBS), and standing shoulder press (SSP). These data were used to estimate the 1 repetition maximum (1RM), which in turn was used to develop the periodization program. Following baseline testing, participants participated in two full-body workouts per week for six weeks. Each individual was retested …

No Differences In Lactate Threshold Across The Menstrual Cycle In Untrained Females, Bianca Alvarenga Rambo Galletti, Grant Chesbro, Rebecca Larson

International Journal of Exercise Science

IInternational Journal of Exercise Science 18(8): 193-205, 2025. In addition to maximal oxygen consumption (VO2max), the Lactate Threshold (LT) is the other major determinant of aerobic exercise performance. This study examined the effects of the menstrual cycle (MC) phase on the LT in untrained females. Eight females and 8 males completed a LT test on a cycle ergometer. The tests were performed across three MC phases: early follicular (EF; menses), ovulatory (O), and mid-luteal (ML). The male participants (control group) were randomly assigned visits at similar time intervals as a regular 28-day cycle. Blood lactate was obtained during the …

Testing As Teaching: A Model For Fitness Assessment Practice And Service-Learning In Exercise Physiology Laboratory Education, Marc Apkarian

Educational Practices in Kinesiology

This resource is intended to provide a model for fitness assessment practice to promote student learning in an undergraduate exercise physiology laboratory course. The goal is for students to gain practical experience in fitness assessment procedures, both through skills practice and service-learning opportunities. The inclusion of an assignment requiring a specified number of assessments to be completed within the term requires additional student practice opportunities. Instruction, demonstration, and initial practice of tests associated with health-related physical fitness components must occur early in the course, so as to permit sufficient opportunities, in class or outside of class, over the remainder of …

What Women Intercollegiate Coaches Say: Decision-Making Factors When Navigating Career Choices, Courtney Boucher, Nicole M. Lavoi

International Journal of Physical Activity and Health

To address misconceptions about the lack of women in sport coaching, factors influencing intercollegiate women coaches' career decisions, including their choices to leave positions, apply for new ones, and accept or deny job offers were explored. Utilizing a multi-level analysis underpinned by critical feminist theory, a comprehensive understanding of the systemic and structural barriers women coaches faced, as well as the strategies they employed to navigate their careers were illuminated. Key findings revealed that unequal pay, lack of administrative support, insufficient resources, and pervasive gender biases significantly impacted women's career choices. The importance of supportive workplace environments, flexible working conditions, …

Benefits, Challenges, And Strategies For Increasing Women Coaches In Elite Sport: The Trail To Gold (T2g) Initiative In U.S. Cross-Country Skiing, Anika Anna Angriman, Lynda B. Ransdell, Shelley Lucas, Nicole Lavoi

International Journal of Physical Activity and Health

Despite tremendous growth in sport participation of girls and women following Title IX in 1972, women’s participation as sport coaches did not follow the same trajectory. In fact, women remain significantly underrepresented in sport coaching. Research highlights ongoing barriers within the sport industry's patriarchal structure, and although strategies have been proposed to improve women’s representation, the lack of progress over the past two decades indicates limited effectiveness. A better approach is essential to address this issue across individual, interpersonal, organizational, and societal levels. The purpose of this study is to interview participants within the U.S. cross-country skiing program, Trail to …

Improper Fitting Personal Protective Clothing And Subsequent Countermeasures For Physical Conditioning In Female Firefighters: A Narrative Review, Katie Sell, Mark Abel, J. Jay Dawes, Megan Thompson, Annette Zapp, Ofra Pottorf, Lilly Bernardi, James Prendergast

International Journal of Physical Activity and Health

The purpose of this paper was to 1) use an explorative literature overview to identify issues related to ill-fitting clothing and occupational gear for female firefighters, and 2) use an inductive approach to develop generalizable recommendations for exercise professionals to utilize by identifying significant themes in published peer reviewed articles related to movement and injury risk. Research, including both qualitative and quantitative approaches, has shown that the majority of current personal protective clothing (PPC) and operational gear was developed to fit a limited array of male physiques. Consequently, the improper fit of PPC and gear has presented numerous concerns that, …

Impact Of A Light Volleyball Intervention Among Older Chinese Adult Women, Ka-Man Carman Leung, Paul Lee, Wing Sze Alice Lai, Yanan Zhao, Lynda Ransdell

International Journal of Physical Activity and Health

Modified sports offer a strategic approach to promoting health in older adults. Light volleyball, which uses a larger, lighter ball than traditional volleyball, is more accessible for this population. This study investigated the effects of a 16-week light volleyball program on the functional fitness of older adults in Hong Kong. A total of 275 participants aged 60 years or older were recruited and randomly assigned to three groups: a light volleyball intervention group, a Tai Chi group, and a control group. Functional fitness was assessed at the pretest, posttest, and 6-month follow-up. Results revealed that the light volleyball group exhibited …

Pull Or Play? The Interpretation Of A Novel, Ai-Powered On-Field Decision Support Tool., Lynne Becker, Dafne Badilla, Osho Yonzon, Xiaoyu Wu, Roland Rocafort, Erik Viogan Phd, Devansh Manocha

Journal for Sports Neuroscience

The document titled "Pull or Play? The interpretation of a novel, AI-powered on-field decision support tool" explores the development and application of the Injury Impact Severity Score (IISS)™ for assessing traumatic brain injuries (TBIs), particularly in sports settings. It addresses the limitations of current assessment tools like the Glasgow Coma Scale (GCS) and proposes a more objective approach using patient-reported data and machine learning algorithms.

Key points include:

• Background: TBIs are a significant health concern with under-reported cases and a lack of effective research. Current assessment tools like the GCS have limitations in accuracy and speed, especially in dynamic …

Fos Expression In The Periaqueductal Gray, But Not The Ventromedial Hypothalamus, Is Correlated With Psychosocial Stress-Induced Cocaine-Seeking Behavior In Rats, Nicole M Hinds, Ireneusz D Wojtas, Desta M Pulley, Stephany J Mcdonald, Colton D Spencer, Milena Sudarikov, Nicole E Hubbard, Colin M Kulick-Soper, Samantha De Guzman, Sara Hayden, Jessica J Debski, Bianca Patel, Douglas P Fox, Daniel F Manvich

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Psychosocial stressors are known to promote cocaine craving and relapse in humans but are infrequently employed in preclinical relapse models. Consequently, the underlying neural circuitry by which these stressors drive cocaine seeking has not been thoroughly explored. Using Fos expression analyses, we sought to examine whether the ventromedial hypothalamus (VMH) or periaqueductal gray (PAG), two critical components of the brain's hypothalamic defense system, are activated during psychosocial stress-induced cocaine seeking. Adult male and female rats self-administered cocaine (0.5 mg/kg/inf IV, fixed-ratio 1 schedule, 2 h/session) over 20 sessions. On sessions 11, 14, 17, and 20, a tactile cue was present …

How Did Covid-19 Impact Physiology Research Globally? – Lessons Learned And Future Recommendations, Jeet Patel, Santanu De

Mako: NSU Undergraduate Student Journal

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused massive changes in the medical field across the globe. As the whole world moved from in-person to remote activities, students found themselves in a predicament where they were compelled towards schooling and work online from home. This would mean that all projects, research, tests, and meetings were conducted over Zoom or other online meeting platforms. Laboratories were shut down or only a limited number of people were allowed to enter to conduct the necessary research. This paper discusses how the COVID-19 pandemic affected research process and experiments within various aspects of the …

Hiv Associated Epigenetic Trends And Chronic Diseases: Insights Into The Hidden Burden Of Chronic Infection, Courtney G. Wallace, Zachary Capriotti, Zachary Klase

Kimmel Cancer Center Faculty Papers

Human Immunodeficiency Virus (HIV) remains a major health challenge despite dramatic advances in treatment and prevention. People living with HIV (PLWH) continue to experience high rates of non-AIDS comorbidities, including cardiovascular, renal, pulmonary, oncologic, and neurocognitive disorders. These conditions persist under viral suppression, underscoring the lasting biological impact of infection. Epigenetic dysregulation has emerged as a key driver of these outcomes. HIV integration, viral proteins, chronic inflammation, and ART exposure have all been reported to alter DNA methylation, histone modifications, transcription factor networks, and noncoding RNA regulation. These changes extend beyond infected cells, reprogramming uninfected immune and tissue compartments. Long-lived …

Associations Between Social Determinants Of Health And Mental Health Disorders Among U.S. Population: A Cross-Sectional Study, S. Tanarsuwongkul

Faculty Publications

Aims

The impact of social determinants of health (SDOH) on mental health is increasingly realized. A comprehensive study examining the associations of SDOH with mental health disorders has yet to be accomplished. This study evaluated the associations between five domains of SDOH and the SDOH summary score and mental health disorders in the United States.

Methods

We analyzed data from a diverse group of participants enrolled in the All of Us research programme, a research programme to gather data from one million people living in the United States, in a cross-sectional design. The primary exposure was SDOH based on Healthy …

The Role Of Social-Psychological Factors In The Adoption Of Push-Pull Technology By Small-Scale Farmers In East Africa: Application Of The Theory Of Planned Behavior, Denis Waiswa, Beatrice Wambui Muriithi, Alice W. Murage, Dave Mwangi Ireri, Fredah Maina, Frank Chidawanyika, Fahri Yavuz

All Peer-Reviewed Publications

Push-pull technology (PPT) continues to gain relevance among smallholder farmers across the East African region in managing the constraints affecting cereal crop yields including stemborers, fall armyworm, striga weed, and low soil fertility. While previous research has emphasized the significance of socioeconomic factors in explaining farmers' decisions to adopt PPT, the social-psychological factors that influence farmers' adoption intentions have not been extensively studied. Therefore, this study investigated the influence of social-psychological factors on the intention to adopt or increase the land area under PPT based on the theory of planned behavior (TPB). Moreover, this study extends the applicability of the …

The Effects Of Anchor Scheme On Performance Fatigability, Neuromuscular Responses, And Perceived Factors That Contributed To Task Termination During Fatiguing Tasks, Dolores G. Ortega, Robert W. Smith, Jocelyn E. Arnett, Tyler J. Neltner, Trevor D. Roberts, Justin S. Pioske, Richard J. Schmidt, Terry J. Housh

Journal for Sports Neuroscience

Purpose: The purpose of this study was to examine the effects of sustained, isometric forearm flexion tasks anchored to a rating of perceived exertion (RPE) versus torque on the composite, inter-, and intra-individual patterns of responses for torque and neuromuscular parameters, as well as the perceived factors that contributed to task termination. Methods: Ten men (mean ± SD: age = 20.9 ± 2.2 yrs.; height = 180.0 ± 5.1 cm; body mass = 81.3 ± 10.0 kg) performed maximal voluntary isometric contractions (MVICs) before and after sustained, isometric forearm flexion tasks anchored to RPE = 6 (RPE6_FT) and …

Neural Correlates Of Infant Attention During Initial Exposure To Own- And Other-Race Faces, Ashley N. Barrows, Lauren Slivka, Kenna Clayton, Kelly Roth, Greg Reynolds

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Past research has shown that infants raised in a racially homogenous environment demonstrate an advantage for processing own-race faces at the individual level in comparison to other-race faces (Lewkowicz, 2014; Mauer & Werker, 2014; Quinn, Lee, & Pascalis, 2018). This advantage for processing own-race faces develops across infancy and has been referred to as the own-race bias (e.g., Anzures, Quinn, Pascalis, Slater, Tanaka, & Lee, 2013). The processes that lead to development of the own-race bias are complex and not fully understood. Recent work suggests that by 10 months of age, differences in own- and other-race face processing may be …

The Functional Fitness Of The Community Dwelling Older Adults In Shan Dong Of Mainland China In Comparison With The Population In Hong Kong, Zongtao Li, Yu Teng, Huigang Wang, Hao Liu, Lei Zhao

International Journal of Physical Activity and Health

Purpose: To compare the functional fitness (FF) of the community dwelling older adults in Shan Dong (SD) of mainland China with their peers in Hong Kong (HK). Methods: 1887 older adults living in SD were measured with Senior Fitness Test (SFT) One sample T test was used to determine the age grooup difference in each FF component between the population of SD and HK. Results: Compared with their HK peers, SD older adults showed higher performance in the task of 30s arm curl, but lower abilities in 30s chair stand, back scratch, chair sit & reach, and 8 ft …

Students' Perceived Value And Emotions In Turkish Physical Education: Testing Moderation By Gender And Sports Involvement, Mehmet Ceylan, Kelly L. Simonton

International Journal of Physical Activity and Health

Physical Education (PE) has been recognized as a key element in developing student enjoyment for physical activity and healthy lifestyle habits. Student emotions may dictate learning and motivation, but less is known regarding the perceptions of value and control that shape these emotions. Specifically, within certain K-12 PE national curriculums and cultures, the goals and objectives of PE, along with its emphasis on physical activity and sport, may influence the emotional response of students and their perceived value of PE. If students feel a lack of value, negative emotions, and marginalized by the content then it is unlikely their experiences …

Neurocognitive Outcomes And Functional Independence In Adult Survivors Of Childhood Medulloblastoma Diagnosed Over 3 Decades, Chiara Papini, Sedigheh Mirzaei, Mengqi Xing, Ingrid Tonning Olsson, Ralph Salloum, Peter M K De Blank, Katharine R Lange, Tricia Z King, Deokumar Srivastava, Wendy M Leisenring, Rebecca M Howell, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman

Faculty, Staff and Student Publications

Background: Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown.

Methods: Adult survivors of childhood medulloblastoma (n = 505; median [minimum-maximum] age, 29 [18-46] years) and sibling controls (n = 727; 32 [18-58] years) from the Childhood Cancer Survivor Study completed surveys assessing neurocognitive problems and chronic health conditions (CHCs). Treatment exposures were categorized as historical (craniospinal irradiation [CSI] ≥ 30 Gy, no chemotherapy), standard-risk (CSI > 0 to < 30 Gy + chemotherapy) and high-risk (CSI ≥ 30 Gy + chemotherapy) therapy. Latent class analysis identified patterns of functional independence using employment, independent living, assistance with routine/personal care needs, driver's license, and marital/partner status. Multivariable models estimated the risk of neurocognitive impairment in survivors versus siblings and by treatment exposure group, and associations between neurocognitive impairment, CHCs, and functional independence.

Results: Survivors in each treatment exposure group had a 4- to 5-fold elevated …