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Improving Reduced Tillage Vegetable Systems For The Northern Great Plains: How Does Early Season Soil Tarping (Solarization And Occultation) Reduce Weeds, Affect Soil Health, And Protect Yield?, Hannah Voye Jan 2025

Improving Reduced Tillage Vegetable Systems For The Northern Great Plains: How Does Early Season Soil Tarping (Solarization And Occultation) Reduce Weeds, Affect Soil Health, And Protect Yield?, Hannah Voye

Electronic Theses and Dissertations

Soil tarping (solarization and occultation) is a no-till weed management practice gaining popularity in the United States for small scale vegetable growers. While many studies have been conducted using variations of this tool in the Northeast United States, minimal research has been done in the windier, sunnier, Midwest climate. Our research explored the effectiveness of early spring solarization and occultation to manage weeds and produce viable onion yield in Eastern South Dakota. Occultation tarps placed in early spring included double sided black and white silage tarps with tarps placed black side up or white side up, each placed 6-, 4-, …


Temporal And Spatial Changes In Phytoplankton Communities In A Shallow Coastal Estuary, Justin Osborne, Jeneil Patel, Jennifer L. Debose Jan 2025

Temporal And Spatial Changes In Phytoplankton Communities In A Shallow Coastal Estuary, Justin Osborne, Jeneil Patel, Jennifer L. Debose

Gulf and Caribbean Research

No abstract provided.


College Athlete Workload Management To Improve Performance, Brody Reid Jan 2025

College Athlete Workload Management To Improve Performance, Brody Reid

Graduate Student Theses, Dissertations, & Professional Papers

Load management is an often used and misunderstood term within the realm of sport science. It has been described as the reason behind numerous soft tissue injuries as well as being the reason star athletes sit on the bench for games. This review aims to synthesize the existing literature regarding the workload management paradox within sport. Seminal work in this topic has been gathered mostly by Tim Gabbett in the paper “The Injury Prevention Paradox” where a relationship between fitness gain and fatigue accrued is outlined. This theory was first proposed by Roger Bannister in 1975. This paper …


Phytogenic Feed Additives Pre- And Post-Calving And Effects Of Substituting Ddgs With Soybean Meal On Protein Metabolism In Beef Cattle, Grace H. Jardon Jan 2025

Phytogenic Feed Additives Pre- And Post-Calving And Effects Of Substituting Ddgs With Soybean Meal On Protein Metabolism In Beef Cattle, Grace H. Jardon

Electronic Theses and Dissertations

The objective of these studies was to evaluate nutritional strategies to improve beef cattle productivity through targeted supplementation and protein source manipulation. The first study investigated the effects of a phytogenic supplement (PHYT; a blend of turmeric, capsicum, and black pepper oleoresin) on colostrum yield and composition, calf passive immunity, and cow–calf performance. Twenty-three Angus-based cows were assigned to either a control group or received 250 or 500 mg/head/day of PHYT from 30 days pre-calving to 60 days post-calving. Supplementation with PHYT linearly increased colostrum fat and calf serum IgA concentrations. Milk fat, calf serum IgG, and colostrum IgM tended …


Effect Of Six-Day Germination On Chemical Composition, Functional, And Nutritional Properties Of Pea Varieties, Hojjat Abdollahikhamene Jan 2025

Effect Of Six-Day Germination On Chemical Composition, Functional, And Nutritional Properties Of Pea Varieties, Hojjat Abdollahikhamene

Electronic Theses and Dissertations

Pulses, particularly peas, have long been a crucial source of protein in vegetarian and cost-effective diets worldwide. They have gained popularity in Western diets as more people turn to plant-based proteins as alternatives to animal products. Peas are known for their high protein content; however, their use in food products has been limited due to factors like poor solubility and digestibility. Germination improves the nutritional profile of peas by enhancing protein content and digestibility. The objective of this study was to determine the effects of six days of germination on the nutritional composition and functional properties of different varieties of …


Investigating The Ruminal Metagenome Of Grass And Forage-Fed Bison To Uncover Metabolic Activities That Impact The Efficiency Of Plant Fiber Utilization, Anlly Fresno Rueda Jan 2025

Investigating The Ruminal Metagenome Of Grass And Forage-Fed Bison To Uncover Metabolic Activities That Impact The Efficiency Of Plant Fiber Utilization, Anlly Fresno Rueda

Electronic Theses and Dissertations

This dissertation investigates the ruminal microbiome of American plains bison (Bison bison) to uncover the metabolic activities that enable efficient utilization of plant fiber, with a particular focus on bacterial composition and functional capabilities in response to forage quality. Using both 16S rRNA gene sequencing and metagenomic approaches, this research provides a comprehensive view of microbial diversity and metabolic potential in the rumen of bison, offering insights into their ecological resilience and efficiency in nutrient extraction. Chapter 2 focuses on the metabolic potential of bacterial communities in the rumen of bison fed a grass-based diet. Using high-throughput sequencing and metagenomic …


Identification Of Gut Bacterial Symbionts From Atlantic Salmon That Are Involved In Metabolizing Feed Ingredients Derived From Soybean Meal, Emily Fowler Jan 2025

Identification Of Gut Bacterial Symbionts From Atlantic Salmon That Are Involved In Metabolizing Feed Ingredients Derived From Soybean Meal, Emily Fowler

Electronic Theses and Dissertations

In the aquaculture industry, plant-based protein sources have emerged as an economically and environmentally sustainable replacement for traditional animal protein sources. Yet, due to reduced digestibility, the presence of anti-nutritional factors, as well as an increased risk of inflammation of the digestive system, the inclusion of plant-based protein ingredients must be limited, especially in the diets of carnivorous fishes. To gain further insight on how to adapt the fish digestive tract to more effectively utilize or tolerate plant-based protein ingredients, slurry from cultured Atlantic Salmon (Salmo salar) was used as a proxy in an in vitro model system to identify …


Synchronization Protocols Utilizing Progesterone Implants Associated With Estrus Expression, Vaginal Microbiome, And Immune Response In Beef Cattle, Riley James Puck Jan 2025

Synchronization Protocols Utilizing Progesterone Implants Associated With Estrus Expression, Vaginal Microbiome, And Immune Response In Beef Cattle, Riley James Puck

Electronic Theses and Dissertations

This thesis aims to provide a deep understanding of presynchronization strategies and the varying factors affecting their efficacy. Beginning with a literature review of the estrous cycle and the endocrinology driving it. Building on this foundation, the physiological basis for estrous synchronization is described, followed by the advancement of pre-synchronization protocols designed to increase estrus and conception. Further, we will focus on the influence of estrus expression on insemination time and conception rates. Finally, how the immune system interacts with the conception process. In addition, the review goes beyond exogenous endocrine manipulation and dives into the emerging role of the …


Determining The Susceptibility Status Of Red Sunflower Seed Weevil, Smicronyx Fulvus (Coleoptera: Curculionidae) To Pyrethroid Insecticides, Aaron Lee Hargens Jan 2025

Determining The Susceptibility Status Of Red Sunflower Seed Weevil, Smicronyx Fulvus (Coleoptera: Curculionidae) To Pyrethroid Insecticides, Aaron Lee Hargens

Electronic Theses and Dissertations

Although sunflowers are native to North America, the early breeding efforts to improve sunflowers occurred outside of the continent. These hybrids were reintroduced to North America around 1875. In the early 1900’s, efforts to increase oil content were achieved by selective breeding of the reintroduced hybrids. Although this resulted in the development of improved sunflowers, many of the traits that conferred resistance to native insect pests were lost. One insect pest, the red sunflower seed weevil was noted as having caused sunflower production to rapidly decline and eventually end in Illinois and Missouri. Unfortunately, red sunflower seed weevils are still …


Fungal Biotransformation Of Thin Stillage And Soybean Hulls And Bacterial Production Of Lysine In Ethanol Industry Co-Products, Bhawana Khadka Jan 2025

Fungal Biotransformation Of Thin Stillage And Soybean Hulls And Bacterial Production Of Lysine In Ethanol Industry Co-Products, Bhawana Khadka

Electronic Theses and Dissertations

Thin stillage (TS) and whole stillage (WS) are major by-products of the corn ethanol industry. These by-products are generated in large quantities and contain nutrients that remain after yeast fermentation. Current industrial utilization of these by-products involves a series of downstream processing steps such as centrifugation and evaporation, which are energy-intensive and often result in nutrient losses. Traditionally, these by-products are dried to produce distillers dried grains with solubles. In this study, microbial fermentation was investigated as an alternative bioprocessing tool to expand the utilization of these by-products. The first objective was to explore the upcycling of TS, both alone …


Extended Days On Feed: Influences On Growth Performance, Efficiency, And Carcass Characteristics Of Steers And Heifers Of Different Proportions Of Angus And Limousin Genetics, Grace Henley Olinger Jan 2025

Extended Days On Feed: Influences On Growth Performance, Efficiency, And Carcass Characteristics Of Steers And Heifers Of Different Proportions Of Angus And Limousin Genetics, Grace Henley Olinger

Electronic Theses and Dissertations

Recently, cattle feeders have extended days on feed (DOF) resulting in hot carcass weights (HCW) exceeding the limits of existing serial slaughter datasets. This study's goal was to determine the impact extended DOF exerts on growth performance, feed efficiency, and carcass characteristics of steers and heifers with varying proportions of Angus (AN) and Limousin (LM) genetics. In 2022, commercial AN cows from two MT ranches were artificially inseminated to 9 sires from 3 breeds (AN, LM, and Limflex (LF)) with parentage confirmed by DNA. In 2023, 216 calves (sired by 72 AN, 73 LF, and 71 LM; 105 steers and …


Whole Genome Sequencing From Snowshoe Hare Fecal Samples, Jessica J. Powell Jan 2025

Whole Genome Sequencing From Snowshoe Hare Fecal Samples, Jessica J. Powell

Graduate Student Theses, Dissertations, & Professional Papers

Genomic analyses can provide powerful insights into important issues in conservation biology, including rapid estimates of overall genetic diversity and related population genetic parameters. Noninvasive DNA sampling from fecal samples is an affordable, efficient, and broadly applicable sampling method that has been used in many targeted genetic analyses. However, the efficacy of whole genome sequencing from fecal samples remains relatively unexplored in most taxa. Here, we present results from two experiments designed to test the quantity and quality of whole genome resequencing data obtained from snowshoe hare (Lepus americanus) fecal pellets. Extensive previous research has used genetic analyses …


Mountain Pine Beetle Host Tree Selection And Climate-Growth Dynamics In Whitebark Pine, Hannah Rose Alverson Jan 2025

Mountain Pine Beetle Host Tree Selection And Climate-Growth Dynamics In Whitebark Pine, Hannah Rose Alverson

Graduate Student Theses, Dissertations, & Professional Papers

Recent climate-driven outbreaks of mountain pine beetles (Dendroctonus ponderosae) in whitebark pine (Pinus albicaulis) have raised fears of increasing whitebark pine mortality with increased warming and drought due to climate change. However, little is known about how whitebark pine responds to climate, what characteristics may predict whitebark pine susceptibility to mountain pine beetle outbreaks, or how these may interact. This information is critical in understanding how whitebark pine might persist in a changing climate. My research investigated how whitebark pine growth responds to various climate variables and how these responses may be predictive of attack by …


Intercellular Mitochondrial Transfer Contributes To Microenvironmental Redirection Of Cancer Cell Fate, Julie Sofie Bjerring, Yara Khodour, Emilee Anne Peterson, Patrick Christian Sachs, Robert David Bruno Jan 2025

Intercellular Mitochondrial Transfer Contributes To Microenvironmental Redirection Of Cancer Cell Fate, Julie Sofie Bjerring, Yara Khodour, Emilee Anne Peterson, Patrick Christian Sachs, Robert David Bruno

School of Medical Diagnostics & Translational Sciences Publications

The mammary microenvironment has been shown to suppress tumor progression by redirecting cancer cells to adopt a normal mammary epithelial progenitor fate in vivo. However, the mechanism(s) by which this alteration occurs has yet to be defined. Here, we test the hypothesis that mitochondrial transfer from normal mammary epithelial cells to breast cancer cells plays a role in this redirection process. We evaluate mitochondrial transfer in 2D and 3D organoids using our unique 3D bioprinting system to produce chimeric organoids containing normal and cancer cells. We demonstrate that breast cancer tumoroid growth is hindered following interaction with mammary epithelial cells …


Effect Of Creatine Monohydrate On Spatialworking Memory, Body Weight, And Food Intake In Male And Female Rats, Cyrilla H. Wideman, Alexandria Iemma, Olivia Janolo, Anastasiya Kalinina, Helen M. Murphy Jan 2025

Effect Of Creatine Monohydrate On Spatialworking Memory, Body Weight, And Food Intake In Male And Female Rats, Cyrilla H. Wideman, Alexandria Iemma, Olivia Janolo, Anastasiya Kalinina, Helen M. Murphy

2025 Faculty Bibliography

Background/Objectives: Creatine monohydrate supplementation has gained popularity in the fitness industry due to its ability to enhance athletic performance and has sparked curiosity about other possible effects of the supplement. The purpose of this study was to examine the effect of creatine supplementation on spatial working memory, body weight, and food intake in male and female rats.

Methods: Experimental rats, six male and six female, were administered creatine while six male and six female rats served as controls. The Morris water maze (MWM) was employed to assess spatial working memory. Body weight and food intake were measured daily.

Results: Neither …


Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus Jan 2025

Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus

All ETDs from UAB

An understanding of nutrition can improve culture of sea urchins, whether as a research model or in the production of seafood products. Macronutrients, including dietary protein sources, can affect growth and reproductive profiles and alter resource allocation to somatic and gametic tissues. Although sea urchins in culture can be fed natural products, diet formulations using various ingredients can be developed to reliably produce desired outcomes. Single-cell protein sources represent a potential alternative to current industry standards of animal-derived protein sources such as fish and squid meal, which are becoming increasingly overfished and expensive. In the present study, we evaluated the …


Reducing Stress: The Role Of The Rcl Operon In Bacterial Stress Response To Hypothiocyanite, Julia Meredith Jan 2025

Reducing Stress: The Role Of The Rcl Operon In Bacterial Stress Response To Hypothiocyanite, Julia Meredith

All ETDs from UAB

The human immune system utilizes a variety of weapons against bacterial communities within the body, which allow it to control the overall microbial population. Understanding how some bacterial species are able to better deal with and survive damage by the immune system while others are not, can help us elucidate the complex relationship between us and our microbiome. One tool that immune cells use for microbial control is the potent oxidant hypothiocyanite/hypothiocyanous acid (-OSCN/HOSCN). The response mounted by Escherichia coli and other bacterial species in order to survive damage caused by HOSCN is the focus of this dissertation. In the …


Variation In Maternal Alkaloid Provisioning And Its Effects On Antimicrobial Defense In Tadpoles Of The Poison Frog Oophaga Pumilio, Erica Berent Jan 2025

Variation In Maternal Alkaloid Provisioning And Its Effects On Antimicrobial Defense In Tadpoles Of The Poison Frog Oophaga Pumilio, Erica Berent

Masters Theses

No abstract provided.


Global Strategies To Manage Huanglongbing (Hlb) And Its Vectors: Insights And Implications For The Mediterranean Region, Meritxell Pérez-Hedo, Mark S. Hoddle, Fernando Alferez, Lochy Batista, George A.C. Beattie, Shourish Chakravarty, Paul Holford, Fathiya Mbarak Khamis, Inusa Jacob Ajene, Aruna Manrakhan, Paul H. Fourie, Maritza Luis, Eduardo Osorio-Hernández, Mamoudou Sétamou, Alejandro Tena, Pedro Takao Yamamoto, Tara Wade, Changyong Zhou, Nian Wang, Lukasz L. Stelinski, Alberto Urbaneja Jan 2025

Global Strategies To Manage Huanglongbing (Hlb) And Its Vectors: Insights And Implications For The Mediterranean Region, Meritxell Pérez-Hedo, Mark S. Hoddle, Fernando Alferez, Lochy Batista, George A.C. Beattie, Shourish Chakravarty, Paul Holford, Fathiya Mbarak Khamis, Inusa Jacob Ajene, Aruna Manrakhan, Paul H. Fourie, Maritza Luis, Eduardo Osorio-Hernández, Mamoudou Sétamou, Alejandro Tena, Pedro Takao Yamamoto, Tara Wade, Changyong Zhou, Nian Wang, Lukasz L. Stelinski, Alberto Urbaneja

All Peer-Reviewed Publications

Huanglongbing (HLB), also known as citrus greening disease, poses a severe threat to the global citrus industry. This disease is caused by three species of bacteria, ‘Candidatus Liberibacter asiaticus’, ‘C. L. africanus’, and ‘C. L. ameri-canus’. The primary pathogen vectors are the Asian citrus psyllid (Diaphorina citri Kuwayama, Hemiptera: Psyllidae) and the African citrus psyllid (Trioza erytreae Del Guercio, Hemiptera: Triozidae). The disease is incurable, and its management relies on reducing vector densities and the adverse effects of bacterial infections on host trees. Managing psyllid vec-tors, especially D. citri, has proven exceptionally challenging due to its rapid spread and subsequent …


Support Needs Of Agrarian Women To Build Household Livelihood Resilience: A Case Study Of The Mekong River Delta, Tran Thi Ngoc Tran Jan 2025

Support Needs Of Agrarian Women To Build Household Livelihood Resilience: A Case Study Of The Mekong River Delta, Tran Thi Ngoc Tran

Dissertations

Problem

Rural livelihood faces significant challenges due to the increasing frequency and severity of climate change impacts. However, the development of women’s livelihood resilience remains constrained by gender-blind policies, limited sex-disaggregated data, and a lack of integration of gender-specific needs and priorities in resilience-building interventions. This study aims to address these critical gaps. This study aims at exploring the perceived support needs of rural agrarian women in building household livelihood resilience to climate change. Specifically, it seeks to (1) understand how household livelihood resilience is perceived by rural agrarian women, and (2) identify the support they require to effectively adapt …


Translating Cardiovascular Clinical Practice Guidelines On Nutrition Therapy: Validation Of The Portfolio Diet Toolkit For Healthcare Providers, Gabrielle Viscardi, Sahba Eskandari, Alyssa Chen, Nicholas Chiang, Meaghan E. Kavanagh, Songhee Back, Micheal Vallis, Mary J. Scourboutakos, Vasanti S. Malik, Cyril W.C. Kendall, David J.A. Jenkins, John L. Sievenpiper, Laura Chiavaroli Jan 2025

Translating Cardiovascular Clinical Practice Guidelines On Nutrition Therapy: Validation Of The Portfolio Diet Toolkit For Healthcare Providers, Gabrielle Viscardi, Sahba Eskandari, Alyssa Chen, Nicholas Chiang, Meaghan E. Kavanagh, Songhee Back, Micheal Vallis, Mary J. Scourboutakos, Vasanti S. Malik, Cyril W.C. Kendall, David J.A. Jenkins, John L. Sievenpiper, Laura Chiavaroli

Department of Family and Community Medicine Faculty Publications

Background

Cardiovascular disease (CVD) remains a leading cause of death in Canada. Although the Portfolio Diet, a dietary pattern of cholesterol-lowering foods, is supported by CVD clinical practice guidelines, its uptake in clinical practice remains limited. This study assessed the content and face validity of a healthcare provider (HCP)-facing toolkit (infographic and video), designed to support implementation of the Portfolio Diet.

Methods

HCPs were recruited for a 2-round evaluation. They assessed the toolkit using a questionnaire. Content validity of the infographic was assessed using a 4-point Likert scale (1 = irrelevant to 4 = extremely relevant) and face validity of …


Beyond Strong: A Phenomenology Of Women Executives And The Connection Between Leadership And Fitness, Nozomi Bullock Jan 2025

Beyond Strong: A Phenomenology Of Women Executives And The Connection Between Leadership And Fitness, Nozomi Bullock

Antioch University Dissertations & Theses

Senior-level executive leaders’ work in a dynamic, competitive, 24/7 business environment can be physically rigorous, mentally demanding, and emotionally isolating. The same holds true for women pursuing senior-level leadership roles in corporate America. Women who achieve and succeed in such roles remain the minority: Outsiders in elite spaces who are held to higher standards and overly scrutinized. Among senior-level executive women leaders, those committed to a fitness and training regimen including weightlifting constitute an even smaller minority. Senior-level executive roles require stamina, resilience, and courage—qualities that make up the foundation of the mindset of fitness and strength training (Foyster et …


Exploring Biostimulant Efficacy Under Limited Fertilizer And Water In Utah's Watermelon Production, Evan Christensen, Milena Oliveira, Prakriti Nepal, Youping Sun Jan 2025

Exploring Biostimulant Efficacy Under Limited Fertilizer And Water In Utah's Watermelon Production, Evan Christensen, Milena Oliveira, Prakriti Nepal, Youping Sun

Plants, Soils and Climate Student Research

The western U.S. has recently experienced some of the driest conditions on record, and Utah has been in a multi-year drought (2019-2023) that affected the agricultural sector, including vegetable producers. While vegetables are not a primary agricultural crop in Utah, they are still an important part of the horticultural economy with 763 farms growing 6,138 acres. As the fourth largest acreage vegetable crop in Utah (almost 10% of the acreage) watermelon and related crops in the gourd family Cucurbitaceae (nearly 36% of total vegetable acreage) are important to vegetable growers. Watermelon is a water-intensive crop and requires an adequate supply …


Analyzing The Population Structure Of The Rhizobia Associated With Astragalus Lentiginosus, Joshua Adam Melnick Jan 2025

Analyzing The Population Structure Of The Rhizobia Associated With Astragalus Lentiginosus, Joshua Adam Melnick

Dissertations

Legumes are an incredibly diverse and agriculturally important family of plants. They have a special relationship with symbiotic bacteria known as rhizobia which fix nitrogen into ammonia within nodules on their roots. Astragalus is the largest plant genus on Earth, and the species Astragalus lentiginosus is extraordinarily diverse, consisting of approximately 40 varieties. However, the rhizobia of A. lentiginosus have never been studied. In this study, root nodules were extracted from 17 varieties of A. lentiginosus to obtain rhizobial strains and metagenomes. A. lentiginosus primarily associates with rhizobia from the genera Mesorhizobium and Allomesorhizobium. There was little evidence of horizontal …


Decoding The Origins Of Infection: A Machine Learning Framework, Nirupama G. Shanbhag Jan 2025

Decoding The Origins Of Infection: A Machine Learning Framework, Nirupama G. Shanbhag

Dissertations

Many infections can be attributed to a specific microorganism. For example, while there can be many causes of urinary tract infections (UTIs), such as the bacterial species Klebsiella pneumoniae or Enterococcus sp., the most widespread cause for UTIs is uropathogenic Escherichia coli. Generally, diseases or infections that are the result of a single pathogenic organism are more easily understood. Other diseases, such as irritable bowel disease (IBD), cannot be attributed to one member in the community; rather, it is a result of dysbiosis of the microbial community (microbiota) of the gastrointestinal tract, a combination of an overgrowth of problematic members …


Cultivating Community-University Partnerships Within The Chicago Region Food System, Hanan Abdillahi, Vivian Cossey, Tania Schusler, Kevin Erickson, Karen Schauwecker, Sarah Ku, Ray Dybzinski Jan 2025

Cultivating Community-University Partnerships Within The Chicago Region Food System, Hanan Abdillahi, Vivian Cossey, Tania Schusler, Kevin Erickson, Karen Schauwecker, Sarah Ku, Ray Dybzinski

School of Environmental Sustainability: Faculty Publications and Other Works

We interviewed 22 organizations in the Chicago Regional Food System to gain insights on their current initiatives, assets, challenges, future visions, and perceived roles of universities in advancing their work. We analyzed themes to report on strong consensus or varied perspectives related to this work. This report aims to advise Loyola’s School of Environmental Sustainability's future work and collaboration activities with Chicago Food System organizations.


Investigation Of Multiple Factors Influencing The Vector-Borne Transmission Of Salmonella Typhimurium Via Blattella Germanica, Landen Sean Van Hulzen Jan 2025

Investigation Of Multiple Factors Influencing The Vector-Borne Transmission Of Salmonella Typhimurium Via Blattella Germanica, Landen Sean Van Hulzen

Dissertations and Theses

The German cockroach (Blattella germanica) is a common urban pest that lives ubiquitously in human structures around the world. German cockroaches are a severe public health threat as they are known carriers and vectors of human pathogens including Salmonella enterica, Escherichia coli, Shigella spp, and more. German cockroach infestations have been associated with Salmonellosis outbreaks. While mechanical transmission by the German cockroach vector is well known, new research suggests that more nuanced biological transmission has a role in maintaining and transmitting Salmonella enterica serovar Typhimurium (S. Typhimurium). Despite this recent finding, many biological variables influencing vector-borne transmission of S. Typhimurium …


Disulfidptosis And Its Emerging Relevance In Cancer And Immunity, Qidong Li, Shengrong Wu, Li Zhuang, Boyi Gan Jan 2025

Disulfidptosis And Its Emerging Relevance In Cancer And Immunity, Qidong Li, Shengrong Wu, Li Zhuang, Boyi Gan

Faculty, Staff and Student Publications

Disulfidptosis is a recently identified form of regulated cell death (RCD) triggered by disulfide stress when cystine uptake via solute carrier family 7 member 1 (SLC7A11) overwhelms the cell's reducing capacity. Unlike apoptosis or other "cell suicide" pathways, disulfidptosis likely represents a "cell sabotage" mechanism, defined by aberrant disulfide bonding and catastrophic actin cytoskeleton collapse. In this Perspective, we examine the paradoxical role of SLC7A11 as both a ferroptosis protector and a disulfidptosis trigger, and the mechanistic hallmarks of disulfidptosis. We highlight emerging therapeutic strategies to target disulfidptosis in cancer, including glucose transporter inhibition, redox-targeting agents, and nanomaterial-based approaches, and …


Correlation Of Pancreatic Laminin Alpha 5 Expression With Clinical Outcomes In Total Pancreatectomy With Islet Autotransplantation, Jayachandra Kuncha, Carly M Darden, Yang Liu, Michael Lawrence, J Sebastian Danobeitia, Bashoo Naziruddin Jan 2025

Correlation Of Pancreatic Laminin Alpha 5 Expression With Clinical Outcomes In Total Pancreatectomy With Islet Autotransplantation, Jayachandra Kuncha, Carly M Darden, Yang Liu, Michael Lawrence, J Sebastian Danobeitia, Bashoo Naziruddin

Faculty, Staff and Student Publications

This study examines extracellular matrix (ECM) protein (ECM) expression in chronic pancreatitis (CP) patients and its correlation with graft function after total pancreatectomy with islet autologous transplantation (TPIAT). Pancreatic sections from 29 CP patients undergoing TPIAT were analyzed for ECM including pan-laminin, laminin alpha 5 (LAMA5), collagen IV, and Perlecan by immunohistochemistry and scored by the percentage positive staining area within the whole tissue area. Graft function was monitored by blood glucose and C-peptide levels. Laminin alpha 5 levels in blood plasma were greater in CP. Laminin alpha 5 expression was significantly higher in all CP patient etiological categories including …


Chronic Circadian Misalignment Accelerates Sarcopenia Progression In Mice, Takashi Seya, Nobuya Koike, Naoki Okubo, Yasuhiro Umemura, Yoshiki Tsuchiya, Kazuya Yabumoto, Yasuhiro Endo, Kanako Iinuma, Akiyo Kakibuchi, Akira Sugimoto, Kenji Takahashi, Seung-Hee Yoo, Zheng Chen, Kazuhiro Yagita Jan 2025

Chronic Circadian Misalignment Accelerates Sarcopenia Progression In Mice, Takashi Seya, Nobuya Koike, Naoki Okubo, Yasuhiro Umemura, Yoshiki Tsuchiya, Kazuya Yabumoto, Yasuhiro Endo, Kanako Iinuma, Akiyo Kakibuchi, Akira Sugimoto, Kenji Takahashi, Seung-Hee Yoo, Zheng Chen, Kazuhiro Yagita

Faculty, Staff and Student Publications

Introduction: In today's 24/7 society, circadian misalignment caused by environmental and lifestyle factors is associated with various adverse health consequences. Understanding tissue-specific pathology is required to counter this growing public health challenge. A potential association of environmental circadian misalignment with sarcopenia, or accelerated loss of skeletal muscle strength and mass, is poorly documented.

Methods: 14-week-old wild-type C57BL/6J male mice were exposed to a chronic jet lag (CJL) paradigm consisting of an 8-h phase advance every 4 days (the ADV group) or a fixed light-dark cycle (the LD group) for 64 weeks. Grip strength was measured during the experiment, and hindlimb …